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Phosphatidylserine, Taurine, and Caffeine for Cognitive Fatigue in Professional Football Players (TCPS-Foot)

9. juli 2026 opdateret af: Krzysztof Mizera, Vizja University in Warsaw

Neurocognitive Fatigue Resistance, Visual Search Efficiency, and Tactical Decision-Making After Phosphatidylserine-Containing Taurine-Caffeine Supplementation in Professional Male Football Players

This randomized, double-blind, placebo-controlled, parallel-group trial will evaluate the effects of 14 days of taurine-caffeine supplementation with or without phosphatidylserine on neurocognitive fatigue resistance, visual search efficiency, and football-specific tactical decision-making in professional male football players. Sixty-two male outfield football players from two professional clubs will be randomized to placebo, taurine plus caffeine, or taurine plus caffeine plus phosphatidylserine. Laboratory and field-based outcomes will be assessed at baseline and after the supplementation period.

Studieoversigt

Status

Ikke rekrutterer endnu

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

This study is designed to determine whether adding phosphatidylserine to a taurine-caffeine supplementation strategy supports attentional control, efficient visual search, and accurate tactical decision-making under acute neurocognitive load in professional male football players.

Participants will complete familiarization, baseline laboratory testing, baseline field testing, 14 days of supplementation, post-intervention laboratory testing, and post-intervention field testing. The laboratory protocol will include a high-load Stroop/Flanker task followed by a football-specific video decision-making task with screen-based eye-tracking. The video task will include offensive and transitional football situations requiring players to select the most appropriate tactical option under time pressure. Some clips will require inhibition of an immediately attractive but suboptimal forward action.

The primary outcome will be the change in tactical inhibitory decision accuracy under neurocognitive load from baseline to post-intervention. Secondary outcomes will include overall decision accuracy, decision time, impulsive tactical errors, mental fatigue, Stroop/Flanker reaction-time variability, time to first fixation on the optimal option, dwell time on the optimal option, situational awareness accuracy, and field-based reactive passing decision performance. Field-based transfer will be assessed using a Reactive Passing Decision Test, the Loughborough Soccer Passing Test, and standardized small-sided games.

Undersøgelsestype

Interventionel

Tilmelding (Anslået)

62

Fase

  • Ikke anvendelig

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiekontakt

Studiesteder

  • Polen
      • Lodz, Polen
        • Professional Football Training Center
        • Kontakt:
      • Warsaw, Polen
        • Professional Football Training Center
        • Kontakt:

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Voksen

Tager imod sunde frivillige

Ja

Beskrivelse

Inclusion Criteria:

  • Male professional outfield football players aged 18 to 37 years.
  • First-team players or selected U19 players aged 18 years or older who are regularly integrated into first-team training.
  • Regular participation in club training.
  • At least 5 years of systematic football training experience.
  • Free from injury or illness limiting full participation in training and testing.
  • Normal or corrected-to-normal vision.
  • Ability to complete the laboratory and field-based testing procedures.
  • Written informed consent provided before participation.

Exclusion Criteria:

  • Goalkeepers.
  • Current injury or illness limiting full participation in testing.
  • Neurological disease.
  • Recent concussion or head trauma.
  • Uncorrected visual impairment.
  • Use of phosphatidylserine, nootropic agents, or strong stimulants during the previous 4 weeks.
  • Non-standard caffeine intake on testing days.
  • Failure to comply with pre-test standardization procedures.
  • Failed eye-tracker calibration.
  • Loss of more than 30% of gaze data during the football-specific decision-making task.
  • Withdrawal of consent.

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Andet
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Firedobbelt

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Placebo komparator: Placebo
Participants randomized to this arm will receive an inert placebo for 14 days. The placebo will be provided in identical coded packs matched for appearance, number of units, and packaging with the active supplements.
Kosttilskud: Placebo
Inert placebo matched with the active supplements for appearance, number of units, and packaging. The placebo will be administered for 14 days.
Aktiv komparator: Taurine Plus Caffeine
Participants randomized to this arm will receive taurine 1500 mg/day plus caffeine 200 mg/day for 14 days. On training and testing days, the supplement will be consumed approximately 60 minutes before the main training session or testing procedure. On non-training days, it will be consumed at a consistent morning time.
Kosttilskud: Taurine Plus Caffeine
Taurine 1500 mg/day plus caffeine 200 mg/day administered for 14 days. On training and testing days, the supplement will be consumed approximately 60 minutes before the main training session or testing procedure. On non-training days, it will be consumed at a consistent morning time.
Eksperimentel: Taurine, Caffeine, and Phosphatidylserine
Participants randomized to this arm will receive taurine 1500 mg/day plus caffeine 200 mg/day plus phosphatidylserine 600 mg/day for 14 days. On training and testing days, the supplement will be consumed approximately 60 minutes before the main training session or testing procedure. On non-training days, it will be consumed at a consistent morning time.
Kosttilskud: Taurine, Caffeine, and Phosphatidylserine
Taurine 1500 mg/day plus caffeine 200 mg/day plus phosphatidylserine 600 mg/day administered for 14 days. On training and testing days, the supplement will be consumed approximately 60 minutes before the main training session or testing procedure. On non-training days, it will be consumed at a consistent morning time.

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Change in Tactical Inhibitory Decision Accuracy Under Neurocognitive Load
Tidsramme: Baseline and 14 days of supplementation
Tactical inhibitory decision accuracy will be assessed using football-specific video clips requiring inhibition of an immediately attractive but suboptimal tactical action. Responses will be scored as 1 point for an optimal decision, 0.5 points for an acceptable decision, and 0 points for an incorrect decision. The outcome will be calculated as the mean score across inhibitory tactical clips. The score ranges from 0 to 1, with higher values indicating better tactical inhibitory decision accuracy.
Baseline and 14 days of supplementation

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Change in Overall Football-Specific Decision Accuracy
Tidsramme: Baseline and 14 days of supplementation
Overall football-specific decision accuracy will be assessed using video-based offensive and transitional football situations. Players will select the most appropriate tactical option under time pressure. The outcome will be expressed as the percentage of correct or expert-rated optimal decisions, with higher values indicating better decision-making accuracy.
Baseline and 14 days of supplementation
Change in Football-Specific Decision Time
Tidsramme: Baseline and 14 days of supplementation
Decision time will be assessed during the football-specific video decision-making task. It will be measured as the time taken to select a tactical response after the critical decision point. The outcome will be expressed in milliseconds, with lower values indicating faster decision-making.
Baseline and 14 days of supplementation
Change in Impulsive Tactical Errors
Tidsramme: Baseline and 14 days of supplementation
Impulsive tactical errors will be assessed during football-specific video clips. These errors will include selections of immediately attractive but suboptimal tactical options, such as inappropriate forward actions, low-quality shots, or forced progressive decisions when a safer or more appropriate option is available.
Baseline and 14 days of supplementation
Change in Stroop/Flanker Reaction-Time Variability
Tidsramme: Baseline and 14 days of supplementation
Reaction-time variability will be assessed during the high-load Stroop/Flanker task used to induce neurocognitive load. The task will assess attentional control, response inhibition, conflict monitoring, and reaction-time stability. The outcome will be expressed in milliseconds.
Baseline and 14 days of supplementation
Change in Post-Task Mental Fatigue
Tidsramme: Baseline and 14 days of supplementation
Mental fatigue will be assessed immediately after the neurocognitive load task using a visual analogue scale. The scale will range from 0 to 10, with higher scores indicating greater perceived mental fatigue.
Baseline and 14 days of supplementation
Change in Time to First Fixation on the Optimal Tactical Option
Tidsramme: Baseline and 14 days of supplementation
Time to first fixation on the optimal tactical option will be assessed using screen-based eye-tracking during the football-specific video decision-making task. The outcome will be expressed in milliseconds and will reflect how quickly the player visually orients toward the expert-defined optimal option.
Baseline and 14 days of supplementation
Change in Dwell Time on the Optimal Tactical Option
Tidsramme: Baseline and 14 days of supplementation
Dwell time on the optimal tactical option will be assessed using screen-based eye-tracking during the football-specific video decision-making task. The outcome will be expressed as the percentage of total viewing time spent fixating on the expert-defined optimal tactical option.
Baseline and 14 days of supplementation
Change in Situational Awareness Accuracy
Tidsramme: Baseline and 14 days of supplementation
Situational awareness accuracy will be assessed using probes presented after selected football-specific video clips. These probes will evaluate whether players correctly identified key tactical information, including available space, pressure location, number of defenders, teammate positioning, and defensive-line configuration.
Baseline and 14 days of supplementation
Change in Reactive Passing Decision Test Accuracy
Tidsramme: Baseline and 14 days of supplementation
Reactive Passing Decision Test accuracy will be assessed during a field-based football-specific task. Players will dribble into a decision zone and respond to a late visual or situational cue by selecting and executing the optimal passing option. The outcome will be expressed as the percentage of accurate decisions.
Baseline and 14 days of supplementation

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Vizja University in Warsaw

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Anslået)

1. juli 2026

Primær færdiggørelse (Anslået)

1. juli 2026

Studieafslutning (Anslået)

1. august 2026

Datoer for studieregistrering

Først indsendt

5. juli 2026

Først indsendt, der opfyldte QC-kriterier

5. juli 2026

Først opslået (Faktiske)

10. juli 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

13. juli 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

9. juli 2026

Sidst verificeret

1. juli 2026

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • MIZERA -4-TCPS-FOOT-2026

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

INGEN

IPD-planbeskrivelse

No individual participant data will be shared because the study includes a small sample of professional football players from a limited number of clubs, which may increase the risk of indirect participant identification. Only aggregated and anonymized study results will be reported.

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

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