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Effect of Aerobic and Resistance Exercise on Quarry Workers (AE RE VF)

2026年8月3日 更新者：Taher Mohamed Kamal Eldin、Cairo University

Aerobic Versus Resistance Exercise Training on Ventilatory Function in Quarry Workers

The goal of this randomized clinical trial is to compare the effects of aerobic exercise training and resistance exercise training on ventilatory function in quarry workers. It will also evaluate their effects on functional capacity and health-related quality of life (HRQOL).

The main questions it aims to answer are:

Does aerobic exercise training improve ventilatory function more effectively than resistance exercise training? How do aerobic and resistance exercise training affect functional capacity and health-related quality of life in quarry workers?

Researchers will compare aerobic exercise training and resistance exercise training with a control group receiving routine treatment and breathing exercises to determine which intervention is more effective in improving ventilatory function, functional capacity, and health-related quality of life.

Participants will:

Be randomly assigned to one of three groups: an aerobic exercise training group, a resistance exercise training group, or a control group.

Receive the assigned intervention three times per week for eight consecutive weeks.

Undergo ventilatory function assessment using spirometry. Complete assessments of functional capacity and health-related quality of life before and after the intervention.

研究概览

地位

招聘中

条件

干预/治疗

详细说明

Quarry workers are routinely exposed to respirable dust, which increases the risk of impaired ventilatory function and reduced physical performance. Long-term occupational dust exposure has been associated with respiratory symptoms, decreased pulmonary function, and poorer health-related quality of life. Exercise-based pulmonary rehabilitation is widely recommended to improve respiratory function and physical capacity; however, limited evidence is available regarding the comparative effectiveness of aerobic versus resistance exercise training in quarry workers. This randomized clinical trial aims to compare the effects of aerobic exercise training and resistance exercise training on ventilatory function in quarry workers. Secondary outcomes include functional capacity and health-related quality of life (HRQOL). Seventy-five clinically stable male quarry workers aged 30-40 years will be randomly allocated into three equal groups: an aerobic exercise training group, a resistance exercise training group, and a control group.

Participants in the aerobic and resistance exercise groups will receive their assigned exercise program in addition to routine medical treatment and breathing exercise training. The control group will receive routine medical treatment and breathing exercise training only. All interventions will be performed three times per week for eight consecutive weeks.

Ventilatory function will be assessed using spirometry, including Forced Vital Capacity (FVC), Forced Expiratory Volume in one second (FEV1), FEV1/FVC ratio, Peak Expiratory Flow (PEF), and Maximum Voluntary Ventilation (MVV). Functional capacity will be evaluated using the Harvard Step Test, while health-related quality of life will be assessed using the St. George's Respiratory Questionnaire (SGRQ). Outcome measures will be collected at baseline and after completion of the intervention period.

The findings of this study are expected to identify the most effective exercise modality for improving ventilatory function, functional capacity, and health-related quality of life among quarry workers, thereby providing evidence to optimize pulmonary rehabilitation programs for this occupational population.

研究类型

介入性

注册 (估计的)

75

阶段

  • 不适用

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习联系方式

  • 姓名：Taher M Kamal Eldin, B.Sc. in physical therapy
  • 电话号码：+201004047580
  • 邮箱：taherkamal364@gmail.com

学习地点

  • 埃及
    • Minya Governorate
      • Minya、Minya Governorate、埃及
        • 招聘中
        • faculty of physical therapy, Deraya University
        • 接触：

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

  • 成人

接受健康志愿者

不

描述

Inclusion Criteria:

  • Male quarry workers.
  • The age range is between 30 and 40 years.
  • BMI values from 25 to 29.9 kg/m².
  • They work 5 to 6 times per weeks with mean exposure range (5-10 years) (Kumar et al., 2014). Exhibited chest manifestations (Respiratory symptoms) like cough, dyspnea, wheeze, and ventilatory impairment with significant reduction in (FEV1/FVC<70% and/or FVC<80% and reduce Peak Expiratory flow 25- 75% (PEF25-75%)(Abdelwahaab et al., 2025).
  • Clinically stable (no exacerbation in past 4-6 weeks).
  • Low levels of physical activity (using the International Physical Activity Questionnaire-Short Version) (The Arabic version of the questionnaire will be used).

Exclusion criteria:

  • Patients with acute respiratory infections or recent exacerbation(4-6 weeks).
  • Asthmatic patient.
  • Chest cancer.
  • Musculoskeletal diseases and other disorders that could potentially impact the study's findings are excluded from the trial.
  • Other major lung diseases (e.g., TB, ILD, bronchiectasis, cancer).
  • Unstable cardiovascular disease.
  • Uncontrolled hypertension.
  • Severe musculoskeletal or neurological limitation to exercise.
  • Cognitive impairment.
  • Participation in PR in past 6 months.
  • Heavy smokers.

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

  • 主要用途：治疗
  • 分配：随机化
  • 介入模型：并行分配
  • 屏蔽：无（打开标签）

武器和干预

参与者组/臂
干预/治疗
实验性的：aerobic exercise group
participants will receive aerobic exercise training in addition to routine medical treatment and breathing exercise training
程序：Aerobic exercise training
participants will receive aerobic exercise training in addition to routine medical treatment and breathing exercise training.
实验性的：resistance exercise group
participants will receive resistance exercise training in addition to routine medical treatment and breathing exercise training.
程序：Resistance exercise training
participants will receive resistance exercise training in addition to routine medical treatment and breathing exercise training.
无干预：control group
participants will receive only routine medical treatment and breathing exercise training

研究衡量的是什么？

主要结果指标

结果测量
措施说明
大体时间
Forced Expiratory Volume in One Second (FEV1)
大体时间：Baseline (pre-intervention) and at the end of the 8-week intervention period (post-intervention).
Forced Expiratory Volume in One Second (FEV1) will be assessed using spirometry. FEV1 is the volume of air forcefully exhaled during the first second of a forced expiratory maneuver and is expressed in liters (L). Higher values indicate better airway function and ventilatory performance.
Baseline (pre-intervention) and at the end of the 8-week intervention period (post-intervention).
Forced Vital Capacity (FVC)
大体时间：Baseline (pre-intervention) and at the end of the 8-week intervention period (post-intervention).
Forced Vital Capacity (FVC) will be assessed using spirometry. FVC is the maximum volume of air that can be forcefully exhaled after a full inspiration and is expressed in liters (L). Higher values indicate better ventilatory function.
Baseline (pre-intervention) and at the end of the 8-week intervention period (post-intervention).
Forced Expiratory Volume in One Second to Forced Vital Capacity Ratio (FEV1/FVC)
大体时间：Baseline (pre-intervention) and at the end of the 8-week intervention period (post-intervention).
The FEV1/FVC ratio will be assessed using spirometry and expressed as a percentage (%). This parameter reflects the proportion of the forced vital capacity exhaled during the first second of expiration and is commonly used to evaluate airflow limitation. Higher values generally indicate better ventilatory function.
Baseline (pre-intervention) and at the end of the 8-week intervention period (post-intervention).
Forced Expiratory Flow at 25-75% of Forced Vital Capacity (FEF25-75%)
大体时间：Baseline (pre-intervention) and at the end of the 8-week intervention period (post-intervention)
Forced Expiratory Flow at 25-75% of Forced Vital Capacity (FEF25-75%) will be assessed using spirometry. FEF25-75% represents the average expiratory flow during the middle half of the forced vital capacity maneuver and is expressed in liters per second (L/s). It is considered a sensitive indicator of small airway function. Higher values indicate better small airway function and ventilatory performance.
Baseline (pre-intervention) and at the end of the 8-week intervention period (post-intervention)
Maximum Voluntary Ventilation (MVV)
大体时间：Baseline (pre-intervention) and at the end of the 8-week intervention period (post-intervention).
Maximum Voluntary Ventilation (MVV) will be assessed using spirometry. MVV is the maximum volume of air inhaled and exhaled voluntarily within one minute and is expressed in liters per minute (L/min). Higher values indicate better respiratory muscle endurance and ventilatory capacity.
Baseline (pre-intervention) and at the end of the 8-week intervention period (post-intervention).
Health-Related Quality of Life
大体时间：Baseline (pre-intervention) and at the end of the 8-week intervention period (post-intervention).
Health-related quality of life will be assessed using the St. George's Respiratory Questionnaire (SGRQ). The SGRQ consists of 50 items grouped into three domains: Symptoms, Activity, and Impacts. Total scores range from 0 to 100, with higher scores indicating poorer health-related quality of life. Lower scores represent better outcomes
Baseline (pre-intervention) and at the end of the 8-week intervention period (post-intervention).

次要结果测量

结果测量
措施说明
大体时间
Functional Capacity
大体时间：Baseline (pre-intervention) and at the end of the 8-week intervention period (post-intervention)
Functional capacity will be assessed using the Harvard Step Test. The Brouha Index (BI) will be calculated based on exercise duration and recovery heart rate. Higher scores indicate better functional capacity
Baseline (pre-intervention) and at the end of the 8-week intervention period (post-intervention)

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Cairo University

调查人员

  • 学习椅：Elsayed E Felaya, Assoiate Professor、Cairo University
  • 研究主任：Shimaa T Taha, Lecturer、Cairo University

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (实际的)

2026年7月9日

初级完成 (估计的)

2026年10月24日

研究完成 (估计的)

2027年1月25日

研究注册日期

首次提交

2026年7月30日

首先提交符合 QC 标准的

2026年7月30日

首次发布 (实际的)

2026年8月4日

研究记录更新

最后更新发布 (实际的)

2026年8月5日

上次提交的符合 QC 标准的更新

2026年8月3日

最后验证

2026年7月1日

更多信息

与本研究相关的术语

其他相关的 MeSH 术语

其他研究编号

  • CU-TMK-19052026

计划个人参与者数据 (IPD)

计划共享个人参与者数据 (IPD)？

不

IPD 计划说明

Individual participant data will not be shared to maintain participant privacy and strictly adhere to confidentiality agreements.

药物和器械信息、研究文件

研究美国 FDA 监管的药品

不

研究美国 FDA 监管的设备产品

不

此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.

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