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Virtual Reality Versus Mental Practice On Balance And Gait In Patients With Multiple Sclerosis

2026年10月30日 更新者:Ola Zaghloul Muhammad Ali Asal、Cairo University

This study is conducted to:

  • Investigate the effect of virtual reality based training on balance and risk of falling.
  • Investigate the effect of virtual reality based training on gait.
  • Investigate the effect of mental practice on balance and risk of falling.
  • Investigate the effect of mental practice on gait.
  • Compare between the effect of virtual reality based training and mental practice on balance and gait

研究概览

详细说明

Background: Multiple sclerosis affects the central integration of sensory afferents that causes disturbance of balance, postural control and gait. Exercise interventions performed through VR applications encourage participants to engage in challenging tasks that integrate motor and cognitive demands, enhance patients' sensory processing and integration systems and allows them to receive information feedback and improve the motivation of training. Mental Practice is a complex cognitive operation that is possible thanks to the use of sensory and perceptive processes that allow an individual to reactivate specific motor actions in the working memory.

Purpose: This study is conducted to Investigate the effect of virtual reality based training on balance and risk of falling, Investigate the effect of virtual reality based training on gait, Investigate the effect of mental practice on balance and risk of falling, Investigate the effect of mental practice on gait and to compare between the effect of virtual reality based training and mental practice on balance and gait.

Methods: Fifty four patients of both sexes with relapsing remitting MS (RRMS). The patients will be diagnosed as having RRMS based on careful clinical examination by neurologist and diagnosis will be confirmed by radiological investigations as magnetic resonance imaging (MRI). Patients will be recruited from the outpatient clinic of Faculty of Physical Therapy, Pharos University in Alexandria and private clinics. Patients in this study will be randomly divided into three groups.

  • Group (I) which will include 18 patients who will receive mental practice in addition to selected physical therapy .
  • Group (II) which will include 18 patients who will receive virtual reality based training in addition to selected physical therapy.
  • Group (III) which will include 18 patients who will receive selected physical therapy.

The treatment will be conducted 3 sessions per week for 6 weeks for 45 minutes.

Results: Data analysis with 2-way mixed Design MANOVA will be used to compare the groups for normally distributed data and Kruskal Wallis and Mann-Whitney tests will be used to compare the groups for non-parametric and not normally distributed data.

研究类型

介入性

注册 (估计的)

54

阶段

  • 不适用

联系人和位置

本节提供了进行研究的人员的详细联系信息,以及有关进行该研究的地点的信息。

学习联系方式

研究联系人备份

学习地点

    • Giza Governorate
      • Giza、Giza Governorate、埃及
        • 招聘中
        • Faculty of Physical Therapy, Cairo University

参与标准

研究人员寻找符合特定描述的人,称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

20年 至 35年 (成人)

接受健康志愿者

不

有资格学习的性别

全部

描述

Inclusion Criteria:

  1. Patients with RRMS.
  2. Patient's age will be range from 20 - 35 years..
  3. Patients are able to walk 10 meter with or without assistance.
  4. Patients with ≤ 6 according to an Expanded Disability Status Scale (EDSS).
  5. Patients are cognitively able to follow instructions.
  6. Patient's body mass index (BMI) will be ranged from 18.5 to 29.99 Kg/m2.

Exclusion Criteria:

  1. Patients with MS relapse in the last 30 days.
  2. Visual impairments interfering with VR.
  3. Severe spasticity or orthopaedic deformity.
  4. Recent musculoskeletal injury.
  5. History of epilepsy or motion sickness with VR.

学习计划

本节提供研究计划的详细信息,包括研究的设计方式和研究的衡量标准。

研究是如何设计的?

设计细节

  • 主要用途:治疗
  • 分配:随机化
  • 介入模型:并行分配
  • 屏蔽:无(打开标签)

武器和干预

参与者组/臂
干预/治疗
实验性的:虚拟现实

The virtual environment presented via Head Mounted Display (HMD) has three-dimensional presentation and the panoramic view that covers the users' field of view, it facilitates immersion in the virtual and distraction from the real world

实验性的:Mental Practice

Mental Practice is among the recommended strategies to enhance performance. MP is a symbolic exercise, involving repeated mental imagery in the absence of any visible muscle contraction.

实验性的:Selected Physical Therapy Program

Dual tasking and Task oriented training in static and dynamic forms

研究衡量的是什么?

主要结果指标

结果测量
措施说明
大体时间
Gait
大体时间:6 weeks

spatial, temporal and angular parameters as cadence, step length and range of motion of hip, knee and ankle will be measured using software analysis "Kinovea" Kinovea is a free, open-source 2D video analysis software. It does not generate a single composite "score". Instead, it measures quantitative biomechanical and kinematic metrics from recorded video.

6 weeks
Gait
大体时间:6 weeks

"10 minutes walk test" will be performed pre and post treatment by asking the patient to walk through a 12 meter walkway and calculate the time for 10 meters in tha walkway in two walking speeds( normal - fast) for 2 or 3 trials of each speed Speed > 1.2 m/s: Normal / Community AmbulatorAble to safely cross street intersections and navigate crowded environments.

0.8 - 1.2 m/s: Limited Community Ambulator/ Able to walk outdoors independently 0.4 - 0.8 m/s: Household Ambulator/ Mostly restricted to indoor walking; requires assistance or equipment outdoors.

< 0.4 m/s: Severe Functional Limitation

6 weeks
Balance
大体时间:6 weeks

static and dynamic balance will be assessed using "Berg Balance Scale" The Berg Balance Scale (BBS) is a 14-item clinical assessment scale designed to measure static balance and dynamic functional mobility, Point Scale: Each of the 14 tasks is rated on a 0 to 4 ordinal scale based on safety, independence, time held, or distance reached, Scores are summed across all items for a overall score ranging from 0 to 56 points (higher scores reflect better balance and mobility).

6 weeks
Balance
大体时间:6 weeks

"Timed Up and Go" test giving numerical data pre and post treatment about balance and risk of falling

Test is scored entirely by time (in seconds):

Time < 10 seconds: Normal / Completely IndependentFreely mobile; minimal to no fall risk 10 - 19 seconds: Mostly Independent, Reasonable balance and gait speed, generally low fall risk 20 - 29 seconds: Variable MobilityImpaired mobility, slower gait speed > 30 seconds: Severely Impaired, high fall risk

6 weeks

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

调查人员

  • 研究主任:Nagwa I Rehab, PhD、Cairo University
  • 研究主任:Rania M Tawfik, PhD、Cairo University
  • 研究主任:Ebtesam M Fahmy, PhD、Cairo University

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查,以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (实际的)

2026年3月1日

初级完成 (估计的)

2027年3月15日

研究完成 (估计的)

2027年3月30日

研究注册日期

首次提交

2026年3月17日

首先提交符合 QC 标准的

2026年10月30日

首次发布 (实际的)

2026年11月5日

研究记录更新

最后更新发布 (实际的)

2026年11月5日

上次提交的符合 QC 标准的更新

2026年10月30日

最后验证

2026年3月1日

更多信息

与本研究相关的术语

计划个人参与者数据 (IPD)

计划共享个人参与者数据 (IPD)?

不

药物和器械信息、研究文件

研究美国 FDA 监管的药品

不

研究美国 FDA 监管的设备产品

不

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