Job Strain, Ambulatory Blood Pressure and Hypertension

May 12, 2016 updated by: National Heart, Lung, and Blood Institute (NHLBI)
To analyze the association between an objective measure of "job strain" and risk of stroke, and change in ambulatory blood pressure.

Study Overview

Status

Completed

Conditions

Detailed Description

BACKGROUND:

Cardiovascular disease accounts for 43 percent of all deaths in the United States. Hypertension affects as many as 50 million Americans, however the causes of essential hypertension are not well known. A new CVD risk factor ("job strain") has emerged as a potential major cause of essential hypertension. By 1995, over 20 studies had found significant positive relationships between "job strain" and CVD, coronary heart disease, all-cause mortality or hypertension. "Job strain" is defined as high psychological workload demands combined with low"decision latitude". An expanded concept of "job strain" which included low workplace social support ("iso-strain") was developed and examined in the study.

Important questions remained to be answered about "job strain", CVD and hypertension. In most studies, "job strain" was only measured at one point in time, while, in fact, cumulative exposure to "job strain" was believed to be the risk factor. In addition, most studies relied on self-report measures of "job strain". Also, no studies specifically examined risk of stroke and "job strain".

DESIGN NARRATIVE:

Data from the Cornell University cohort study of Psychosocial Factors and Cardiovascular Disease and the Columbia University-Northern Manhattan Stroke Study were analyzed. The study had five specific aims, including to determine whether: blood pressure levels were associated with cumulative exposure to "job strain"; differences in blood pressure increases were associated with an objective measure of "job strain"; increased risk of stroke was associated with an objective measure of "job strain"; changes in psychological variables over time were associated with job characteristics; changes in CVD risk factors (other than hypertension) were associated with job characteristics.

Paul Landsbergis also constructed measures of cumulative exposure to "job strain" and determined their association with blood pressure, and analyzed the association between job characteristics and change in psychological variables and cardiovascular disease (CVD) risk factors.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

Study Type

Observational

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

No older than 100 years (Child, Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

Male

Description

No eligibility criteria

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

National Heart, Lung, and Blood Institute (NHLBI)

Investigators

  • Paul Landsbergis, Weill Medical College of Cornell University

Publications and helpful links

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General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

September 1, 1996

Study Completion (Actual)

August 1, 1998

Study Registration Dates

First Submitted

May 25, 2000

First Submitted That Met QC Criteria

May 25, 2000

First Posted (Estimate)

May 26, 2000

Study Record Updates

Last Update Posted (Estimate)

May 13, 2016

Last Update Submitted That Met QC Criteria

May 12, 2016

Last Verified

August 1, 2004

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 4954
  • R03HL055165 (U.S. NIH Grant/Contract)

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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