Heart Failure and Postoperative Outcome in Surgery - a National Registry Study

June 2, 2026 updated by: Umeå University

Incidence of Heart Failure and Its Association With Postoperative Mortality in Surgery - a National Registry Study

The study is an exploratory study that aims to explore the incidence of heart failure in a national surgical cohort, and to compare postoperative mortality and morbidity in patients with and without heart failure. Furthermore, we want to investigate differences in the incidence of heart failure and its impact on postoperative morbidity and mortality in day surgery compared to inpatient surgery.

Study Overview

Status

Not yet recruiting

Conditions

Study Type

Observational

Enrollment (Estimated)

2200000

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

  • Name: Tomi Myrberg, Associate professor
  • Phone Number: +46920282236
  • Email: tomi.myrberg@umu.se

Study Locations

  • Sweden
      • Luleå, Sweden
        • Region Norrbotten, department of Anesthesia and Intensive Care, Sunderby Hospital
        • Principal Investigator:
          • Tomi Myrberg, Associate professor
      • Umeå, Sweden
        • Institution for Diagnostic and Intervention, dep of Anestesiology and Intensive care
        • Contact:
        • Principal Investigator:
          • Tomi Myrberg, Associate professor

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Patients ≥18 years of age who underwent surgery in Sweden between 1 Jan 2021-31 Dec 2024.

Description

Inclusion Criteria:

  • ≥18 years of age who underwent surgery in Sweden between 1 Jan 2021-31 Dec 2024 and SPOR registered operation.

Exclusion Criteria:

  • ASA 6 (deceased patient, organ donation).
  • Cardiac surgery

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Surgery with SPOR registration
Surgery registered in SPOR registry between 2021--2024

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Postoperative mortality
Time Frame: 365 days
How does a heart failure diagnosis affect postoperative mortality at 30 days, 90 days, 180 days, and 365 days?
365 days
Postoperative morbidity
Time Frame: 30 days postoperative
How does a heart failure diagnosis associated with postoperative morbidity at 30 days?
30 days postoperative

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Prevalence of heart failure
Time Frame: 5 years preoperative
What is prevalence of heart failure in surgery in Sweden?
5 years preoperative

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
Differences between ambulatory and inpatient surgery
Time Frame: 365 postoperative
Is there difference between ambulatory respective elective surgery regarding mortality and morbidity after surgery?
365 postoperative
Difference in prevalence of heart failure
Time Frame: 5 years preoperative
Is there difference in prevalence regarding ambulatory and inpatient surgery
5 years preoperative

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Umeå University

Collaborators

Region Norrbotten

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

  • 1. Griffiths R, Beech F, Brown A, Dhesi J, Foo I, Goodall J, et al. Peri-operative care of the elderly 2014: Association of Anaesthetists of Great Britain and Ireland. Anaesthesia. 2014;69 Suppl 1:81-98. 2. Weiser TG, Haynes AB, Molina G, Lipsitz SR, Esquivel MM, Uribe-Leitz T, et al. Estimate of the global volume of surgery in 2012: an assessment supporting improved health outcomes. Lancet. 2015;385 Suppl 2:S11. 3. Eriksson J, Sandberg C, Kilhamn N, Bell M, Oldner A, Larsson E. Surgery in patients aged ≥ 80 years: mortality and recovery in a nationwide cohort study. Anaesthesia. 2025;80(7):812-22. 4. McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). With the special contribution of the Heart Failure Association (HFA) of the ESC. European journal of heart failure. 2022;24(1):4-131. 5. Lindberg F, Benson L, Dahlström U, Lund LH, Savarese G. Trends in Heart Failure Mortality in Sweden Between 1997 and 2022. European journal of heart failure. 2024;27(2):366-76. 6. Shah KS, Xu H, Matsouaka RA, Bhatt DL, Heidenreich PA, Hernandez AF, et al. Heart Failure With Preserved, Borderline, and Reduced Ejection Fraction: 5-Year Outcomes. J Am Coll Cardiol. 2017;70(20):2476-86. 7. Levy D, Kenchaiah S, Larson MG, Benjamin EJ, Kupka MJ, Ho KK, et al. Long-term trends in the incidence of and survival with heart failure. N Engl J Med. 2002;347(18):1397-402. 8. Hernandez AF, Whellan DJ, Stroud S, Sun JL, O'Connor CM, Jollis JG. Outcomes in heart failure patients after major noncardiac surgery. J Am Coll Cardiol. 2004;44(7):1446-53. 9. van Diepen S, Bakal JA, McAlister FA, Ezekowitz JA. Mortality and Readmission of Patients With Heart Failure, Atrial Fibrillation, or Coronary Artery Disease Undergoing Noncardiac Surgery. Circulation. 2011;124

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

August 1, 2026

Primary Completion (Estimated)

March 1, 2027

Study Completion (Estimated)

December 1, 2030

Study Registration Dates

First Submitted

June 2, 2026

First Submitted That Met QC Criteria

June 2, 2026

First Posted (Actual)

June 9, 2026

Study Record Updates

Last Update Posted (Actual)

June 9, 2026

Last Update Submitted That Met QC Criteria

June 2, 2026

Last Verified

June 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Dnr 2026-01286-01
  • 36223/2026 (Registry Identifier: National Cause of Death Register, Sweden)
  • DAT-1428 (Other Identifier: The Swedish Perioperative Registry (SPOR))

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

Not actual in this study concept

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Heart Failure

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Japan

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

Subscribe