- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00060788
Antisocial Behavior: Passing From Parent to Child to Grandchild
Intergenerational Transmission of Antisocial Behavior
Study Overview
Status
Detailed Description
While it is well-known that antisocial behavior runs in families, little is known about the specific mechanisms by which it is transmitted from one generation to the next. This prospective study will examine biological influences on transgenerational continuity and change, and how biology interacts with social factors in modulating the transmission of antisocial behavior. The study is unique in that it includes both mothers and fathers, focuses on early mechanisms, and addresses female as well as male antisocial behavior.
This study is part of the continuing Mauritius Child Health Project. The project began by testing 1,795 children age 3 years old on psychophysiological, behavioral, nutritional, and cognitive measures. Both male and female children were tested. Their parents were also assessed for psychosocial influences. One hundred children then participated in a nutritional, exercise, and educational enrichment intervention from ages 3 to 5 years old. The intervention has been shown to increase physiological arousal and attention at age 11 years and to reduce conduct disorder at age 17 years.
These 3-year-old children are now 30-year-old adults. This study will retest these adults on psychophysiological, psychosocial, cognitive, behavioral, parenting, and antisocial behavior measures. Their previously untested spouses will also be assessed. Finally, many of these adults now have 3-year-old children of their own; these children will be evaluated as well. Measures of life stress, daily hassles, family conflict, mental illness, and criminal behavior will be assessed. Data from the enrichment cohort will be evaluated to determine if the intervention disrupted the intergenerational transmission of antisocial behavior from the second to third generations.
Study Type
Enrollment
Contacts and Locations
Study Locations
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Quatre Bornes, Mauritius
- Recruiting
- Joint Child Health Project
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Contact:
- Hughon Sophie, B.A.
- Phone Number: 230-453-9123
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Child of a participant tested in previous Mauritius Child Health Project studies
Study Plan
How is the study designed?
Design Details
Collaborators and Investigators
Investigators
- Principal Investigator: Adrian Raine, University of Southern California
Study record dates
Study Major Dates
Study Start
Study Completion
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ESTIMATE)
Study Record Updates
Last Update Posted (ESTIMATE)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 1R01HD42259-1
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