Study of TLK286 (Telcyta) vs. Gefitinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Phase 3 Randomized Study of TLK286 (Telcyta) Versus Gefitinib (Iressa) as Third-Line Therapy in Locally Advanced or Metastatic Non-Small Cell Lung Cancer

The purpose of this study is to determine if TLK286(Telcyta) is more effective than gefitinib (Iressa) in the treatment of non-small cell lung cancer.

Study Overview

• Status: Completed
• Conditions: Non Small Cell Lung Carcinoma
• Intervention / Treatment: Drug: TLK286 (Telcyta) HCl for Injection; Drug: gefitinib (Iressa)

• Study Type: Interventional
• Enrollment: 520
• Phase: Phase 3

Contacts and Locations

Study Locations

• Argentina
  • Buenos Aires, Argentina, 1437
    • Complejo Medico de la Policia Federal Argentina "Churruca-Visca" - Servicio de Oncologia
  • Buenos Aires, Argentina, C1405DCS
    • Hospital General de Agudos "Carlos G. Durand" - Servicio de Oncologia
  • Buenos Aires, Argentina, C1426ANZ
    • Instituto Alexander flaming
  • Cordoba, Argentina, 5000
    • Sociedad de Beneficencia Hospital Italiano
  • Rosario, Argentina, 2000
    • Instituto CAICI
  • San Martin, Argentina, 1650
    • H.I.G.A. Eva Peron
  • Buenos Aires
    • Bahia Blanca, Buenos Aires, Argentina, B8000LMA
      • Policlínica Privada Instituto de Medicina Nuclear
    • Capital Federal, Buenos Aires, Argentina, C1280AEB
      • Hospital Britanico de Buenos Aires
    • Capital Federal, Buenos Aires, Argentina, C1405BWU
      • Hospital de Oncologia Maria Curie
    • Capital Federal, Buenos Aires, Argentina, C1406FWY
      • Hospital Alvarez
    • Capital Federal, Buenos Aires, Argentina, C1408INH
      • Hospital Donacion F. Santojanni
    • Pilar, Buenos Aires, Argentina, 1629
      • Hospital Universitario Austral - Servicio de Oncologia
  • Mar del Plata
    • Cordoba, Mar del Plata, Argentina, 7602
      • Hospital Privado de Comunidad
• Australia
  • Bankstown, Australia, 2200
    • Bankstown Lidcombe Hospital - Department of Medical Oncology
  • Hobart, Australia, 7000
    • Royal Hobart Hospital
  • Nedlands, Australia, 6009
    • Sir Charles Gairdner Hospital
  • St. Leonards, Australia, 2065
    • Royal North Shore Hospital-Medical Oncology Dept.
  • Wodonga, Australia, 3690
    • Border Medical Oncology - Murray Valley Private Hospital
  • Wollongong, Australia, 2500
    • Clinical Trials Centre - Wollongong Hospital
  • New South Wales
    • Albury, New South Wales, Australia, 2640
      • Albury Base Hospital
    • Albury, New South Wales, Australia, 2640
      • West Albury Barker's Pharmacy
    • Waratah, New South Wales, Australia, 2298
      • Department of Medical Oncology-Newcastle Mater Misericordiae Hospital
  • Queensland
    • South Brisbane, Queensland, Australia, 4101
      • Department of Oncology
  • South Australia
    • Bedford Park, South Australia, Australia, 5041
      • Flinders Medical Centre
  • Victoria
    • Fitzroy, Victoria, Australia, 3065
      • St. Vincent's Hospital
    • West Melbourne, Victoria, Australia, 3003
      • Pharmatel Fresenius Kabi Pty Ltd.
    • Wodonga, Victoria, Australia, 3690
      • Murray Valley Private Hospital
• Brazil
  • BA
    • Salvador, BA, Brazil, 40170-070
      • Nucleo de Oncologia da Bahia
  • CE
    • Fortaleza, CE, Brazil, 60430-230
      • Instituto do Cancer do Ceará
  • GO
    • Goiania, GO, Brazil, 74605-070
      • Associacao de Combate ao cancer de Goias - Hospital
  • MG
    • Belo Horizonte, MG, Brazil, 30180-090
      • Hospital Vera Cruz
  • PR
    • Curitiba, PR, Brazil, 80060-150
      • Hospital das Clínicas da UFPR
    • Curitiba, PR, Brazil, 86010-640
      • Pro Onco Centro de Tratamento Oncologico S/C Ltda.
  • RS
    • Porto Alegre, RS, Brazil, 90610-000
      • Hospital Sao Lucas - PUCRS
    • Porto Alegre, RS, Brazil, 90610-000
      • Hospital Sao Lucas-Pucrs
  • SP
    • Santo Andre, SP, Brazil, 09090-780
      • Santo Andre Diagnostico e Tratamento Ltda
    • Santo Andre, SP, Brazil, 09090-780
      • Santo Andre Diagnosticos e Tratamentos Ltda.
    • Santo Andre, SP, Brazil, 09090-780
      • Santo Andre Diagnosticos e Tratamentos
    • Sao Paulo, SP, Brazil, 01224-010
      • Instituto do Cancer Arnaldo Vieira de Carvalho
    • Sao Paulo, SP, Brazil, 01327-002
      • Complexo Hospitalar Heliopolis
    • Sao Paulo, SP, Brazil, 04039-032
      • Universidade Federal de Sao Paulo - UNIFESP/EPM
    • Sao Paulo, SP, Brazil, 05403-000
      • Hospital das Clinicas - Universidade de Sao Paulo
    • Sao Paulo, SP, Brazil, 14784-400
      • Fundacao Pio XII - Hospital do Cancer de Barretos
    • Sao Paulo, SP, Brazil, 18030-210
      • Conjunto Hospitalar de Sorocaba
• Chile
  • Santiago, Chile
    • Hospital Clinico Universidad de Chile
  • Santiago, Chile
    • Instituto Nacional del Cancer
  • Santiago, Chile
    • Clínica Santa María
  • Santiago, Chile
    • Clinica Las Condes
  • Santiago, Chile
    • Hospital Militar
  • Santiago, Chile
    • FundacionArturo Lopez Perez
  • Santiago, Chile
    • Hospital FACH
  • Santiago, Chile
    • Instituto Nacional del Cancer - Servicio de Radioterapia
  • Las Condes
    • Santiago, Las Condes, Chile
      • Departmento de Hemato-Oncologia
• Germany
  • Haale, Germany, 06120
    • Stadtisches Krankenhaus Martha-Maria Halle-Dolau GmbH
  • Hamburg, Germany, 22081
    • IORC GmbH
  • Hamburg, Germany, 20099
    • Allgemeines Kraken Haus St. Georg Onkologie
  • Gauting
    • Robert-Koch-Allee 2, Gauting, Germany, 82131
      • Askllepios Fachkliniken
  • Grosshansdorf
    • Woehrendamm 80, Grosshansdorf, Germany, 22927
      • KH GroBhansdorf - Abt. fuer Thoraxonkologie
  • Hamburg
    • Lademannbogen 8, Hamburg, Germany, 22339
      • Laborgemeinschaft Hamburg
    • Lohmuehlstr.5, Hamburg, Germany, 20099
      • Allgemeines Krankenhaus St. Georg
  • Karlshure
    • Sudendstrasse 32, Karlshure, Germany, 76147
      • St. Vincentius-Kliniken gAG
  • Rohrbach BW
    • Heidelberg, Rohrbach BW, Germany, 69126
      • Thoraxklinik-Heidelberg GmbH
• Italy
  • Parma, Italy, 43100
    • Azienda Ospedaliera di Parma - U.O. di Oncologia
  • Catania
    • Via Palermo, Catania, Italy, 95122
      • Ospedale Garibaldi di Nesima - Oncologia Medica
  • Mantova
    • Via Albertoni, Mantova, Italy, 46100
      • Ospedale "Carlo Poma" - Divisione di Oncologia Medica ed
• United Kingdom
  • Bristol, United Kingdom, BA21 4AT
    • Bristol Haemotolgy and Oncology Centre
  • Dundee, United Kingdom, DD1-9SY
    • Div. of cancer Medicine - Princess Alexandra Centre-Ninewells Hospital & Medical School
  • London
    • West Smithfield, London, United Kingdom, EC1A 7BE
      • Department of Medical Oncology
• United States
  • Alabama
    • Birmingham, Alabama, United States, 35233
      • University of Alabama at Birmingham
    • Birmingham, Alabama, United States, 35294
      • University of Alabama at Birmingham
    • Birmingham, Alabama, United States, 35233-2115
      • UAB CCC Clinical Studies Unit
    • Birmingham, Alabama, United States, 35233
      • Department of Veterans Affairs Medical Center
  • Arizona
    • Glendale, Arizona, United States, 85304
      • Palo Verde Hematology Oncology
  • Arkansas
    • Benton, Arkansas, United States, 72015
      • Little Rock Hematology Oncology Benton
    • Bentonville, Arkansas, United States, 72702
      • Highlands Oncology Group
    • Fayetteville, Arkansas, United States, 72703
      • Highlands Oncology Group
    • Hot Springs, Arkansas, United States, 71913
      • Heritage Physician Group, Oncology
    • Little Rock, Arkansas, United States, 72205
      • University of Arkansas for Medical Sciences
    • Springdale, Arkansas, United States, 72764
      • Highlands Oncology Group
  • California
    • Antioch, California, United States, 94509
      • East Bay Medical Oncology/Hematology Medical Associates, Inc.
    • Burbank, California, United States, 91505
      • Providence Saint Joseph Medical Center
    • Burbank, California, United States, 91505
      • East Valley Hematology Oncology Medical Group
    • Chula Vista, California, United States, 91911
      • Marilyn Norton, M. D.
    • Chula Vista, California, United States, 91911
      • Rosalba Rodriquez, M. D.
    • Concord, California, United States, 94520
      • Bay Area Cancer Research Group
    • Glendora, California, United States, 91741
      • Wilshire Oncology Medical Group, Inc.
    • La Mesa, California, United States, 91942
      • Grossmont Hospital
    • La Mesa, California, United States, 91942
      • Sharp Rees-Stealy
    • La Verne, California, United States, 91750
      • Wilshire Oncology Medical Group, Inc.
    • Mission Hills, California, United States, 91345
      • Providence Holy Cross Medical Center
    • Mission Hills, California, United States, 91345
      • North Valley Hematology Oncology Group
    • Montebello, California, United States, 60460
      • Clinical Trials and Research Associates, Inc.
    • Montebello, California, United States, 90640
      • Beverly Oncology & Imaging
    • Montebello, California, United States, 90640
      • Beverly Oncology and Imaging Center, Inc.
    • Montebello, California, United States, 90640
      • Clinical Trials & Research Associates, Inc.
    • Montebello, California, United States, 90640
      • Oncology Care Medical Associates, Inc.
    • Oceanside, California, United States, 92056
      • N. County Oncology Medical
    • Pasadena, California, United States, 91105
      • Wilshire Oncology Medical Group, Inc.
    • Pomona, California, United States, 91767
      • Wilshire Oncology Medical Group, Inc.
    • Rancho Cucamonga, California, United States, 91730
      • Wilshire Oncology Medical Group, Inc.
    • San Diego, California, United States, 92123
      • Medical Oncology Associates - Sd
    • San Diego, California, United States, 92123
      • Sharp Rees-Stealy
    • San Diego, California, United States, 92123
      • Sharp Memorial Hospital
    • San Diego, California, United States, 92120
      • Southern California Permanente Medical Group
    • San Gabriel, California, United States, 91776
      • Oncology Care Medical Associates, Inc.
    • San leandro, California, United States, 94578
      • East Bay Medical Oncology/Hematology Medcial Associates, Inc.
    • Santa Monica, California, United States, 90404
      • Santa Monica Hematology/Oncology
    • Walnut Creek, California, United States, 94598
      • Diablo Valley Oncology & Hematology Medical Group, Inc.
    • West Covina, California, United States, 91790
      • Wilshire Oncology Medical Group, Inc.
    • Whittier, California, United States, 90602
      • Oncology Care Medical Associates, Inc.
  • Connecticut
    • Hamden, Connecticut, United States, 06518
      • Medical Oncology & Hematology, P. C.
    • Meriden, Connecticut, United States, 06451
      • Medical Oncology & Hematology, P.C.
    • New Haven, Connecticut, United States, 06510
      • Medical Oncology & Hematology, P. C.
    • New Haven, Connecticut, United States, 06511
      • Medical Oncology & Hematology, P. C.
    • New Milford, Connecticut, United States, 06776
      • New Milford Hospital
    • New Milford, Connecticut, United States, 06776
      • Northwestern Connecticut Oncology/Hematology
    • Sharon, Connecticut, United States, 06069
      • Northwestern Connecticut Oncology/Hematology
    • Sharon, Connecticut, United States, 06069
      • Sharon Hospital
    • Torrington, Connecticut, United States, 06790
      • Charlotte Hungerford Hospital
    • Torrington, Connecticut, United States, 06790
      • Northwestern Connecticut Oncology/Hematology
    • Waterbury, Connecticut, United States, 06708
      • Medical Oncology & Hematology, P.C.
  • District of Columbia
    • Washington, District of Columbia, United States, 20007
      • Georgetown University Hospital
    • Washington, District of Columbia, United States, 20010
      • Washington Hospital Center - Washington Cancer Institute
  • Florida
    • Altamonte Springs, Florida, United States, 32701
      • Moroose, Reynolds, Castillo, Robinson & Lukeman, MD, PA
    • Boca Raton, Florida, United States, 33486
      • The Center for Hematology/Oncology
    • Bonita Springs, Florida, United States, 34135
      • Florida Cancer Specialists
    • Bradenton, Florida, United States, 34209
      • Florida Cancer Specialists
    • Cape Coral, Florida, United States, 33990
      • Florida Cancer Specialists
    • Clearwater, Florida, United States, 33756
      • Morton Plant Hospital
    • Clearwater, Florida, United States, 33756
      • Hitesh Patel
    • Clearwater, Florida, United States, 33756
      • Joseph DeFelice
    • Clearwater, Florida, United States, 33756
      • Oncology Physicians
    • Clearwater, Florida, United States, 33761
      • Oncology Physicians
    • Cocoa Beach, Florida, United States, 32931
      • Space Coast Medical Associates
    • Delray Beach, Florida, United States, 33484
      • The Center for Hematology/Oncology
    • Fort Lauderdale, Florida, United States, 33308
      • Broward Oncology Associates
    • Fort Myers, Florida, United States, 33901
      • Florida Cancer Specialists
    • Fort Myers, Florida, United States, 33908
      • Florida Cancer Specialists
    • Fort Myers, Florida, United States, 33901
      • Florida Cancer Speicalists
    • Ft. Lauderdale, Florida, United States, 33308
      • Broward Oncology Associates
    • Hollywood, Florida, United States, 33021
      • South Florida Oncology Hematology
    • Jacksonville, Florida, United States, 32207
      • Florida Oncology Associates
    • Jacksonville, Florida, United States, 32209
      • Shands Jacksonville
    • Jacksonville, Florida, United States, 32209
      • University of Florida/Jacksonville Faculty Clinic
    • Jacksonville, Florida, United States, 32204
      • Florida Oncology Associates
    • Jacksonville, Florida, United States, 32218
      • Florida Oncology Associates
    • Jacksonville, Florida, United States, 32223
      • Florida Oncology Associates
    • Jacksonville Beach, Florida, United States, 32250
      • Florida Oncology Associates
    • Lakeland, Florida, United States, 33805
      • Lakeland Regional Cancer Center
    • Lakeland, Florida, United States, 33805
      • Lakeland Regional Medical Center
    • Merritt Island, Florida, United States, 32952
      • Space Coast Medical Associates
    • Naples, Florida, United States, 34102
      • Florida Cancer Specialists
    • Naples, Florida, United States, 34119
      • Florida Cancer Specialists
    • Ocala, Florida, United States, 34471
      • Mohammad Kamal, M. D.
    • Ocala, Florida, United States, 34480
      • Ocala Research Institute, Inc.
    • Orange Park, Florida, United States, 32073
      • Florida Oncology Associates
    • Orlando, Florida, United States, 32603
      • Florida Hospital
    • Orlando, Florida, United States, 32804
      • Hematology & Oncology Consultants, PA
    • Orlando, Florida, United States, 32804
      • Moroose, Reynolds, Castillo, Robinson & Lukman, MD, PA
    • Ormond Beach, Florida, United States, 32174
      • Florida Hospital Memorial Division, Cancer Care Center
    • Palatka, Florida, United States, 32177
      • Florida Oncology Associates
    • Palm Beach Gardens, Florida, United States, 33410
      • Palm Beach Cancer Institute
    • Port Charlotte, Florida, United States, 33980
      • Florida Cancer Specialists
    • Port St. Lucie, Florida, United States, 34952
      • Hematology/Oncology Associates of the Treasure Coast
    • Sarasota, Florida, United States, 34232
      • Florida Cancer Specialists
    • Sarasota, Florida, United States, 34236
      • Florida Cancer Specialists
    • St. Augustine, Florida, United States, 32086
      • Florida Oncology Associates
    • Venice, Florida, United States, 34285
      • Florida Cancer Specialists
    • Venice, Florida, United States, 34292
      • Florida Cancer Specialists
    • Wellington, Florida, United States, 33414
      • Palm Beach Cancer Institute
    • West Palm Beach, Florida, United States, 33401
      • Palm Beach Cancer Institute
    • Winter Park, Florida, United States, 32792
      • Hematology & Oncology Consultants, PA
  • Georgia
    • Atlanta, Georgia, United States, 30309
      • Peachtree Hematology & Oncology Consultants, P. C.
    • Fayetteville, Georgia, United States, 30214
      • Peachtree Hematology & Oncology Consultants, P. C.
  • Hawaii
    • Honolulu, Hawaii, United States, 96813
      • Straub Clinic & Hospital
    • Honolulu, Hawaii, United States, 96826
      • Kapiolani Medical Center for Women & Children
  • Illinois
    • Barrington, Illinois, United States, 60010
      • North Shore Oncology Hematology Associates
    • Chicago, Illinois, United States, 60625
      • Swedish Covenant Cancer Center
    • Decatur, Illinois, United States, 62526
      • Cancer Care Specialists of Central IL
    • Decatur, Illinois, United States, 62526
      • Decatur Memorial Hospital/Clinical Research
    • Effingham, Illinois, United States, 62401
      • Cancer Care Specialists of Central IL
    • Flossmoor, Illinois, United States, 60422
      • Joliet Oncology-Hematology Associates, Ltd.
    • Galesburg, Illinois, United States, 61401
      • Galesburg Cottage Hospital
    • Galesburg, Illinois, United States, 61401
      • Medical & Surgical Specialists, LLC
    • Galesburg, Illinois, United States, 61401
      • St. Mary Medical Center
    • Joliet, Illinois, United States, 60435
      • Joliet Oncology-Hematology Associates, Ltd.
    • Lake Forest, Illinois, United States, 60045
      • Deerpath Medical Associates
    • Libertyville, Illinois, United States, 60048
      • North Shore Oncology Hematology Associates
    • McHenry, Illinois, United States, 60050
      • North Shore Oncology Hematology Associates
    • Morris, Illinois, United States, 60450
      • Joliet Oncology-Hematology Associates, Ltd.
    • Skokie, Illinois, United States, 60076
      • Hematology Oncology Associates of Illinois (HOAI)
    • Skokie, Illinois, United States, 60076
      • North Shore Cancer Research Association
    • Skokie, Illinois, United States, 60076
      • Midwest Cancer Research Group, Inc.
    • Zion, Illinois, United States, 60099
      • Midwestern Regional Medical Center
  • Indiana
    • Elkhart, Indiana, United States, 46514
      • Elkhart General Hospital
    • Goshen, Indiana, United States, 46526
      • Center for Cancer Care at Goshen Health System
    • Indianapolis, Indiana, United States, 46202
      • Indiana University Cancer Center
    • Indianapolis, Indiana, United States, 46202
      • Wishard Hospital
    • Indianapolis, Indiana, United States, 46202
      • Indiana University-Clarian Health Partners
    • Indianapolis, Indiana, United States, 46202
      • Veterans Administration
    • Jeffersonville, Indiana, United States, 47130
      • Cancer Care Center
    • La Porte, Indiana, United States, 46350
      • LaPorte Hospital
    • Muncie, Indiana, United States, 47303
      • Medical Consultants, Pc
    • New Albany, Indiana, United States, 47150
      • Cancer Care Center
    • New Castle, Indiana, United States, 47362
      • Ball Cancer Center at Forest Ridge Medical Pavilion
    • South Bend, Indiana, United States, 46601
      • Memorial Hospital of South Bend
    • South Bend, Indiana, United States, 46617
      • Saint Joseph's Regional Medical Center
    • Vincennes, Indiana, United States, 47591
      • Medical Center of Vincennes
    • Vincennes, Indiana, United States, 47591
      • Tricare
  • Iowa
    • Bettendorf, Iowa, United States, 52722
      • Hematology Oncology Associates of the Quad Cities
    • Davenport, Iowa, United States, 52803
      • Genesis Health System
  • Kansas
    • Kansas City, Kansas, United States, 66112
      • Kansas City Cancer Center
    • Overland Park, Kansas, United States, 66210
      • Kansas City Cancer Center
  • Maryland
    • Annapolis, Maryland, United States, 21401
      • Annapolis Oncology Center
    • Baltimore, Maryland, United States, 21237
      • Franklin Square Hospital Center
    • Baltimore, Maryland, United States, 21237
      • Auerbach Hematology Oncology Associates
    • Bethesda, Maryland, United States, 20817
      • Center For Cancer And Blood Disorders
    • Kensington, Maryland, United States, 20895
      • Associates in Oncology/Hematology, P.C.
    • Rockville, Maryland, United States, 20850
      • Associates in Oncology/Hematology, P.C.
  • Massachusetts
    • Worcester, Massachusetts, United States, 01608
      • Department of Hematology/Oncology
    • Worcester, Massachusetts, United States, 01608
      • Fallon Clinic Pharmacy-Linda Tolf, R.Ph.
    • Worcester, Massachusetts, United States, 01608
      • Saint Vincent Hospital/Worcester Medical Center-Paul Seed, R.Ph.D
  • Michigan
    • Ann Arbor, Michigan, United States, 48106
      • St. Joseph Mercy Hospital, Cancer Center, OC 139
    • Lansing, Michigan, United States, 48909
      • Sparrow Health System
    • Lansing, Michigan, United States, 48912
      • Sparrow Health System
    • Niles, Michigan, United States, 49120
      • Lakeland Hospital
    • St. Joseph, Michigan, United States, 49085-2158
      • Lakeland Hospital
  • Minnesota
    • Duluth, Minnesota, United States, 55805
      • Duluth Clinic
  • Missouri
    • Columbia, Missouri, United States, 65201
      • Missouri Cancer Associates
    • Columbia, Missouri, United States, 65201
      • Boone Hospital Center
    • Columbia, Missouri, United States, 65203
      • Ellis Fischel Cancer Center - University of Missouri Health Care
    • Joplin, Missouri, United States, 64804
      • Freeman Health System
    • Joplin, Missouri, United States, 64804
      • Freeman Cancer Institute
    • Kansas City, Missouri, United States, 64131
      • Kansas City Cancer Center
    • Kansas City, Missouri, United States, 64111
      • Kansas City Cancer Center
    • Kansas City, Missouri, United States, 64154
      • Kansas City Cancer Center
    • Lee's Summit, Missouri, United States, 64064
      • Kansas City Cancer Center
    • St. Louis, Missouri, United States, 63131
      • Missouri Baptist Medical Center
  • Nebraska
    • Omaha, Nebraska, United States, 68114
      • Nebraska Methodist Hospital
    • Scottsbluff, Nebraska, United States, 69361
      • Horizons West Medical Group
  • Nevada
    • Las Vegas, Nevada, United States, 89109
      • Nevada Cancer Centers
    • Las Vegas, Nevada, United States, 89128
      • Nevada Cancer Centers
  • New Jersey
    • East Brunswick, New Jersey, United States, 08816
      • Central Jersey Oncology Center
    • Newark, New Jersey, United States, 07103
      • University Hospital
    • Voorhees, New Jersey, United States, 08043
      • Cooper Cancer Institute
  • New Mexico
    • Albuquerque, New Mexico, United States, 87109
      • New Mexico Oncology Hematology Consultants, Ltd.
  • New York
    • Albany, New York, United States, 12208
      • New York Oncology Hematology, P. C.
    • Armonk, New York, United States, 10504
      • Business Park Drive
    • Bronx, New York, United States, 10467
      • Montefiore Medical Center
    • Bronx, New York, United States, 10461
      • Albert Einstein Cancer Center at the Montefiore Medical Park
    • Bronx, New York, United States, 10461
      • The Jack D. Weiler Hospital of the Albert Einstein College of Medicine
    • East Setauket, New York, United States, 11733
      • North Shore Hematology Oncology Associates, P.C.
    • Fresh Meadows, New York, United States, 11365
      • Queens Medical Associates
    • Latham, New York, United States, 12110
      • New York Oncology Hematology, P.C.
    • Malone, New York, United States, 12953
      • Alice Hyde Medical Center
    • Malone, New York, United States, 12953
      • Myrna Sanchez, MD
  • North Carolina
    • Cary, North Carolina, United States, 27511
      • Raleigh Hematology Oncology Associates
    • Cary, North Carolina, United States, 27511
      • Raleigh Hematology Oncology Association
    • Charlotte, North Carolina, United States, 28203
      • Carolinas Hematology-Oncology Associates
    • Charlotte, North Carolina, United States, 28203
      • Carolinas HealthCare System/Carolinas Medical Center
    • Durham, North Carolina, United States, 27704
      • Regional Hematology Oncology Associates
    • Durham, North Carolina, United States, 27704
      • Regional Hematology Oncology Association
    • Gastonia, North Carolina, United States, 28054
      • Gaston Hematology & Oncology Associates
    • Raleigh, North Carolina, United States, 27607
      • Raleigh Hematology Oncology Associates
    • Raleigh, North Carolina, United States, 27609
      • Raleigh Hematology Oncology Association
    • Raleigh, North Carolina, United States, 27607
      • Raleigh Hematology Oncology Association
    • Raleigh, North Carolina, United States, 27609
      • Raleigh Hematology Oncology Associates
    • Winston Salem, North Carolina, United States, 27103
      • Piedmont Hematology Oncology Associates
  • North Dakota
    • Bismarck, North Dakota, United States, 58501
      • Odyssey Research
    • Bismarck, North Dakota, United States, 58501
      • Cancer Treatment & Research Center
    • Fargo, North Dakota, United States, 58103
      • Dakota Cancer Institute
    • Fargo, North Dakota, United States, 58103
      • Odyssey Research
  • Ohio
    • Cleveland, Ohio, United States, 44106
      • Case Western Reserve University- University Hospitals of Cleveland
    • Columbus, Ohio, United States, 43215
      • Mid Ohio Oncology/Hematology, Inc.
    • Columbus, Ohio, United States, 43213
      • Mid Ohio Oncology/Hematology, Inc.
    • Columbus, Ohio, United States, 43222
      • Mid Ohio Oncology/Hematology
    • Elyria, Ohio, United States, 44035
      • Community Health Partners, Ireland Cancer Center
    • Orange Village, Ohio, United States, 44122
      • UHHS Chagrin Highlands - Ireland Cancer Center
    • Westerville, Ohio, United States, 43081
      • Mid Ohio Oncology/Hematology, Inc.
    • Westlake, Ohio, United States, 44145
      • UHHS Westlake - Ireland Cancer Center
  • Oklahoma
    • Norman, Oklahoma, United States, 73071
      • Cancer Care Associates
    • Oklahoma City, Oklahoma, United States, 73120
      • Cancer Care Associates
    • Oklahoma City, Oklahoma, United States, 73112
      • Cancer Care Associates
    • Oklahoma City, Oklahoma, United States, 73102
      • Cancer Care Associates
    • Oklahoma City, Oklahoma, United States, 73109
      • Cancer Care Associates
    • Tulsa, Oklahoma, United States, 74136
      • Cancer Care Associates
    • Tulsa, Oklahoma, United States, 74104
      • Cancer Care Associates
    • Tulsa, Oklahoma, United States, 74133
      • Cancer Care Associates
  • Oregon
    • Portland, Oregon, United States, 97227
      • Kaiser Permanente Northwest Region
  • Pennsylvania
    • Bethlehem, Pennsylvania, United States, 18015
      • Vita Hematology Oncology, P.C.
    • Philadelphia, Pennsylvania, United States, 19104
      • Hospital of the University of Pennsylvania
    • Philadelphia, Pennsylvania, United States, 19114
      • Greater Philadelphia Cancer and Hematology Specialists, PC
    • Sayre, Pennsylvania, United States, 18840
      • Robert Packer Hospital
    • Sayre, Pennsylvania, United States, 18840
      • Guthrie Clinic
  • South Carolina
    • Charleston, South Carolina, United States, 29425
      • Medical University of S.C.
    • Easley, South Carolina, United States, 29640
      • Cancer Centers of the Carolinas
    • Greenville, South Carolina, United States, 29605
      • Cancer Centers of the Carolinas
    • Greenville, South Carolina, United States, 29615
      • Cancer Centers of the Carolinas
    • Greenwood, South Carolina, United States, 29646
      • Cancer Centers of the Carolinas
    • Seneca, South Carolina, United States, 29672
      • Cancer Centers of the Carolinas
    • Spartanburg, South Carolina, United States, 29307
      • Cancer Centers of the Carolinas
  • Tennessee
    • Chattanooga, Tennessee, United States, 37404
      • Memorial Hospital
    • Chattanooga, Tennessee, United States, 37404
      • Chattanooga Oncology & Hemtology Associates, P. C.
    • Franklin, Tennessee, United States, 37067
      • The Consultant Group, P.C.
    • Gallatin, Tennessee, United States, 37066
      • The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC
    • Hermitage, Tennessee, United States, 37076
      • The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC
    • Knoxville, Tennessee, United States, 37920
      • Baptist Hospital of East Tennessee
    • Knoxville, Tennessee, United States, 37916
      • Thompson Oncology Group
    • Knoxville, Tennessee, United States, 37920
      • East Tennessee Oncology/Hematology, P.C.
    • Knoxville, Tennessee, United States, 37922
      • Baptist Hospital West
    • Knoxville, Tennessee, United States, 37922
      • East Tennessee Oncology/Hematology, P.C.
    • Knoxville, Tennessee, United States, 37932
      • Thompson Oncology Group
    • Lebanon, Tennessee, United States, 37087
      • The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC
    • Maryville, Tennessee, United States, 37804
      • Thompson Oncology Group
    • Murfreesboro, Tennessee, United States, 37130
      • The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC
    • Nashville, Tennessee, United States, 37203
      • The Sarah Cannon Cancer Center
    • Nashville, Tennessee, United States, 37205
      • The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC
    • Nashville, Tennessee, United States, 37207
      • The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC
    • Nashville, Tennessee, United States, 37211
      • The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC
    • Nashville, Tennessee, United States, 37205
      • The Consultant Group, P.C.
    • Oak Ridge, Tennessee, United States, 37830
      • Cumberland Oncology & Hematology
    • Smyrna, Tennessee, United States, 37167
      • The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC
  • Texas
    • Arlington, Texas, United States, 76012
      • Arlington Cancer Center
    • Dallas, Texas, United States, 75231
      • Texas Cancer Associates, LLP
    • Dallas, Texas, United States, 75237
      • Dallas Oncology Consultants, PA
    • Dallas, Texas, United States, 75230
      • Center for Oncology Research and Treatment, PA
    • Dallas, Texas, United States, 75208
      • Dallas Oncology Consultants, PA
    • Fort Worth, Texas, United States, 76132
      • Southwest Fort Worth Cancer Center
    • Ft. Worth, Texas, United States, 76104
      • Texas Oncology, P.A.
    • Houston, Texas, United States, 77030
      • The University of Texas - M. D. Anderson Cancer Center
    • Richardson, Texas, United States, 75080
      • Center for Oncology Research and Treatment, PA
  • Virginia
    • Nassawadox, Virginia, United States, 23413
      • Shore Cancer Center
  • Washington
    • Federal Way, Washington, United States, 98003
      • Northwest Medical Specialists, PLLC
    • Lakewood, Washington, United States, 98499
      • Northwest Medical Specialties, PLLC
    • Tacoma, Washington, United States, 98405
      • Northwest Medical Specialists, PLLC
  • Wisconsin
    • Elkhorn, Wisconsin, United States, 53121
      • VLCC-Elkhorn
    • Milwaukee, Wisconsin, United States, 53215
      • Medical Consultants, Ltd.
    • Slinger, Wisconsin, United States, 53086
      • Aurora Health Center-Slinger
    • West Bend, Wisconsin, United States, 53095
      • VLCC-West Bend

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Clinical diagnosis of non-small cell lung cancer
• Non-small cell lung cancer that is not curable with surgery, radiation, or combined modality chemoradiation
• Failed two prior chemotherapy regimens which must have included platinum
• Measurable disease

Exclusion Criteria:

• Treatment with more than two prior chemotherapy regimens
• History of bone marrow transplantation or stem cell support
• Pregnant or lactating women
• Known history of prior gefitinib therapy
• Known history of prior TLK286 therapy

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Collaborators and Investigators

• Sponsor: Telik

Study record dates

Study Major Dates

• Study Completion: May 1, 2005

Study Registration Dates

• First Submitted: March 26, 2004
• First Submitted That Met QC Criteria: March 29, 2004
• First Posted (Estimate): March 30, 2004

Study Record Updates

• Last Update Posted (Estimate): January 15, 2008
• Last Update Submitted That Met QC Criteria: January 10, 2008
• Last Verified: March 1, 2006

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Respiratory Tract Diseases; Neoplasms; Lung Diseases; Neoplasms by Site; Respiratory Tract Neoplasms; Thoracic Neoplasms; Carcinoma, Bronchogenic; Bronchial Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Molecular Mechanisms of Pharmacological Action; Enzyme Inhibitors; Antineoplastic Agents; Protein Kinase Inhibitors; Gefitinib
• Other Study ID Numbers: TLK286.3020