- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00108173
Brain Reaction to Treatment of Nicotine Dependence
Neural Substrates of Treatment for Nicotine Dependence
The purpose of the study was to determine how the treatments for cigarette craving work.
Hypothesis: During exposure to cigarette-related cues, heavy smokers will have greater reductions in regional brain activation from before to after both forms of active treatments than from before to after placebo.
Study Overview
Detailed Description
Study Type
Enrollment (Actual)
Phase
- Phase 1
Contacts and Locations
Study Locations
-
-
California
-
West Los Angeles, California, United States, 90073
- VA Greater Los Angeles Healthcare System, West LA
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Heavy smoker, more than one pack per day
- Free of medical conditions or medications that affect brain activity
- Not pregnant
Exclusion Criteria:
Drug or alcohol dependence Mental Illness Pregnancy Medications that affect brain function Unstable medical conditions
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Diagnostic
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Other: Arm 1
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
2-FA PET scan results
Time Frame: Within the first few weeks of study initiation
|
Brain activity and activation in response to cigarette-related cues
|
Within the first few weeks of study initiation
|
Collaborators and Investigators
Investigators
- Principal Investigator: Arthur L. Brody, MD, VA Greater Los Angeles Healthcare System, West LA
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- ADRD-018-02S
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Nicotine Dependence
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