- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00152659
Developing Criteria for Cortical Resections
April 24, 2023 updated by: University of Chicago
Developing Functional and Structural Criteria for Cortical Resections
The purpose of this study is to study how disease processes like tumors or epilepsy spread in the brain.
Study Overview
Status
Completed
Intervention / Treatment
Detailed Description
The purpose of this study is to study how disease processes like tumors or epilepsy spread in the brain.
During surgery small pieces of abnormal (unusual) brain tissue may be removed.
We analyze these specimens using more advanced microscopic and electrophysiologic techniques than are usually applied to such tissue specimens.
In addition, some tissues can be maintained in laboratory conditions to allow analysis over the longer term.
No extra brain tissue is taken to perform these studies.
The tissue analysis is performed by the research team and are compared to the routine (normal) electrical recordings that are taken during this type of brain surgery.
Currently there are no instructions telling a doctor how much brain tissue should be cut out to prevent the spread of tumors or epilepsy.
We are hoping that the results of this study help us to better know how much brain tissue needs to be removed to prevent the spread of tumors or epilepsy.
Study Type
Observational
Enrollment (Actual)
87
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Wim van Drongelen, Ph.D.
- Phone Number: 773-834-9049
- Email: wvandron@peds.bsd.uchicago.edu
Study Contact Backup
- Name: Jan-Marino Ramirez, Ph.D.
- Phone Number: 773-702-3713
- Email: jramire@uchicago.edu
Study Locations
-
-
Illinois
-
Chicago, Illinois, United States, 60637
- The University of Chicago Hospitals, The University of Chicago Comer Children's Hospital
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
No
Sampling Method
Non-Probability Sample
Study Population
Surgical candidates with epilepsy or brain tumor(s)
Description
Inclusion Criteria:
- Surgical candidates with epilepsy or brain tumor(s)
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
measure electrical activity in tissue sample
Time Frame: at tissue aremoval time
|
at tissue aremoval time
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Wim van Drongelen, Ph.D., University of Chicago
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Ramirez J-M, Koch H, Pena F, Drongelen W van, Tryba AK, Parkis MA, Loweth JA, Hecox KE, Kohrman MH, Frim DM, Chico MS, Marcuccilli CJ (2003) - In vitro electrophysiological differences between least and most abnormal tissue obtained from pediatric patients with intractable epilepsy. Epilepsia 44, Suppl 9: 245-246
- Marcuccilli CJ, Koch H, Pena F, Drongelen W van, Tryba AK, Parkis MA, Hecox KE, Kohrman MH, Frim DM, OConnor SE, Chico MS, Ramirez J-M (2003) - Rational pharmacotherapy: relationship between in vitro electrophysiology and clinical measures. Epilepsia 44, Suppl 9: 244-245
- Drongelen W van, Koch H, Marcuccilli CJ, Viemari J, Tryba AKH, Loweth JA, Ramirez J-M, Elsen F (2004) - Persistent sodium current plays a critical role in the generation of slow oscillations in vitro neocortex brain slices of mice and humans. Abstract Soc Neuroscience
- Drongelen W van, Doren EL, Koch H, Marcuccilli CJ, Ramirez J-M, Elsen FP (2005) - Characterization of the persistent sodium current in neocortical networks of mice and humans. Abstract Washington DC: Society for Neuroscience
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
September 1, 1998
Primary Completion (Actual)
November 14, 2022
Study Completion (Actual)
November 14, 2022
Study Registration Dates
First Submitted
September 7, 2005
First Submitted That Met QC Criteria
September 8, 2005
First Posted (Estimate)
September 9, 2005
Study Record Updates
Last Update Posted (Actual)
April 26, 2023
Last Update Submitted That Met QC Criteria
April 24, 2023
Last Verified
April 1, 2023
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 9538
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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