- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00183833
Study of Xeloda and Gleevec in Patients With Advanced Solid Tumors
Phase I/II Study of Xeloda and Gleevec in Patients With Advanced Solid Tumors
This study is for people with solid tumors cancer for which the standard chemotherapy drugs have not worked. The purpose of this research is to evaluate the side effects of Xeloda (also called capecitabine) in combination with a new anticancer agent called Gleevec (also called imatinib mesylate). Xeloda is an anticancer drug, and can be taken by mouth. The active ingredient is a well-studied cancer drug called 5-FU. Xeloda is approved by the FDA for the treatment of colon cancer. Gleevec is approved in the US for the treatment of patients with a leukemia called CML (increase of white blood cells) after failure of standard therapy. It is also approved by the FDA for patients with Gastrointestinal Stromal Tumors (a rare tumor in the digestive tract).
This study will test how much Gleevec we can safely give with Xeloda. Xeloda will be given at the recommended dose for colorectal cancer and Gleevec will be given in increasing amounts.
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Actual)
Phase
- Phase 1
Contacts and Locations
Study Locations
-
-
California
-
Los Angeles, California, United States, 90033
- USC/Norris Cancer Center
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Histologically or cytologically confirmed metastatic or unresectable solid tumor for which standard curative or palliative measures do not exist or are no longer effective.
- SWOG performance status 0-2.
- ANC greater than 1500, platelets greater than 100,000.
- Total bilirubin less than 2 x upper limit of normal, or less than 3 x upper limit of normal in patients with liver metastasis. Transaminase (AST and/or ALT) less than 2 x upper limit of normal or less than 3 x upper limit of normal in patients with liver metastasis.
- Serum creatinine less than 1.25 x institutional upper limit of normal.
- Female patients of childbearing potential must have negative pregnancy test within 7 days before initiation of study drug dosing.
Exclusion Criteria:
- Patient has received any other investigational agent- within 28 days of first day of study drug dosing.
- Patient with another primary malignancy except if the other primary malignancy is neither currently clinically significant nor requiring active intervention.
- Patient has another severe and/or life-threatening medical disease.
- Patient has an acute or known chronic liver disease (e.g., chronic active hepatitis, cirrhosis).
- Patient has a known diagnosis of human immunodeficiency virus (HIV) infection.
- Patient has received chemotherapy within 4 weeks (6 weeks for nitrosourea, mitomycin-C or any antibody therapy) prior to study entry unless urgent enrollment needed and approved by Novartis.
- Patient had a major surgery within 2 weeks prior to study entry.
- Patients with symptomatic brain metastasis.
- Patient with Grade III/IV cardiac problems as defined by the New York Heart Association Criteria (e.g. congestive heart failure, myocardial infarction within 6 months of study)
- Medical, social or psychological factors interfering with compliance.
- Patients under therapeutic coumadin therapy.
- Patients under routine systemic corticosteroid therapy.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: A
Xeloda plus gleevec
|
Capecitabine and imatinib mesylate will both be taken by mouth twice a day
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
To determine the dose limiting toxicity (DLT) and maximum tolerated dose (MTD) of Gleevec in combination with a fixed dose of Xeloda po bid daily in patients with colon cancer.
Time Frame: 4 weeks
|
4 weeks
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
To determine the time to progression, survival and response rate.
Time Frame: Until Patient goes off study
|
Until Patient goes off study
|
To obtain preliminary data on molecular correlates to determine clinical efficacy
Time Frame: Until Patient Goes off study
|
Until Patient Goes off study
|
Toxicity.
Time Frame: 30 days after patient receives last drug dose
|
30 days after patient receives last drug dose
|
Collaborators and Investigators
Collaborators
Investigators
- Principal Investigator: Heinz-Josef Lenz, M.D., U.S.C./Norris Cancer Center
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Digestive System Diseases
- Neoplasms
- Neoplasms by Site
- Gastrointestinal Neoplasms
- Digestive System Neoplasms
- Gastrointestinal Diseases
- Colonic Diseases
- Intestinal Diseases
- Intestinal Neoplasms
- Rectal Diseases
- Colorectal Neoplasms
- Colonic Neoplasms
- Molecular Mechanisms of Pharmacological Action
- Enzyme Inhibitors
- Antimetabolites, Antineoplastic
- Antimetabolites
- Antineoplastic Agents
- Protein Kinase Inhibitors
- Capecitabine
- Imatinib Mesylate
Other Study ID Numbers
- 3C-02-1
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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