- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00190970
The Effect of Ruboxistaurin on Small Fiber Function
July 25, 2016 updated by: Chromaderm, Inc.
The Effect of Ruboxistaurin Mesylate (LY333531) on Small Fiber Function as Measured by Microvascular Skin Blood Flow, C-Fiber Quantitations in Skin and Quantitative Sensory Testing of Cold and Heat.
To determine the effect of Ruboxistaurin on small fiber function.
Study Overview
Study Type
Interventional
Enrollment
52
Phase
- Phase 2
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Virginia
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Norfolk, Virginia, United States
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Patients must have Type 1 or Type 2 diabetes mellitus
- Patients must have bilateral sensorimotor distal peripheral neuropathy attributable to diabetes mellitus
- Patients must have blood glucose control measured as HbA1c=<11%
- Patients must be 18 years of age or older.
- Patients must be able to return to all follow-up visits
Exclusion Criteria:
- Patients must not have symptoms of diabetic peripheral neuropathy that cannot be distinguished from other etiologies
- Patients must not have a neurologic disease or neuropathy from a cause other than diabetes mellitus that would interfere with correct evaluation of symptomatic peripheral neuropathy.
- Patient currently has uncontrolled high blood pressure
- You have other medical problems that your doctor feels would make it unsafe for you to participate in this study such as liver or kidney problems
- You are a woman of childbearing age and unwilling or unable to use effective contraceptive.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
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The objectives of this study is to evaluate the effect of ruboxistaurin on subjects with diabetic peripheral polyneuropathy
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Secondary Outcome Measures
Outcome Measure |
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Ruboxistaurin will improve quantitative sensory testing and increase nerve fiber density in subjects with diabetic peripheral polyneuropathy.
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
October 1, 2004
Study Completion
November 1, 2005
Study Registration Dates
First Submitted
September 12, 2005
First Submitted That Met QC Criteria
September 12, 2005
First Posted (Estimate)
September 19, 2005
Study Record Updates
Last Update Posted (Estimate)
July 26, 2016
Last Update Submitted That Met QC Criteria
July 25, 2016
Last Verified
July 1, 2016
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 7550
- B7A-MC-MBDO
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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Tanta UniversityCompletedDiabetic Neuropathies | Diabetic Peripheral Neuropathy | Painful Diabetic Neuropathy | Autonomic Neuropathy | Diabetic Polyneuropathy | Small Fiber NeuropathyEgypt
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Clinical Trials on Ruboxistaurin
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Chromaderm, Inc.CompletedDiabetic Neuropathies | Diabetes Mellitus, Non-Insulin-Dependent | Diabetes Mellitus, Insulin-DependentCanada, United States, Croatia, Finland, India, Lithuania, Netherlands, United Kingdom
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Chromaderm, Inc.Heart and Stroke Foundation of CanadaCompletedDiabetes Mellitus, Type 1Canada
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Eli Lilly and CompanyCompletedDiabetes Mellitus | Diabetic NeuropathiesUnited States, Spain, Australia, Belgium, Canada, Croatia, Denmark, Estonia, Finland, Germany, Hungary, India, Lithuania, Netherlands, United Kingdom
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Eli Lilly and CompanyCompletedDiabetic Neuropathies | Diabetes Mellitus, Non-Insulin-Dependent | Diabetes Mellitus, Insulin-DependentUnited States, Spain, Hungary, Australia, Belgium, Denmark, Estonia, Germany, Israel
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Chromaderm, Inc.CompletedDiabetic RetinopathyUnited States
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Chromaderm, Inc.CompletedDiabetic RetinopathyUnited States, Canada, France, Denmark, Australia, Netherlands, Taiwan, Spain, Italy, Germany, Portugal, United Kingdom, Russian Federation, Poland, India, Brazil, Mexico
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Chromaderm, Inc.Completed
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Chromaderm, Inc.CompletedDiabetic NephropathyUnited States
-
Chromaderm, Inc.Completed
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University of TennesseeThe Christ HospitalWithdrawn