Autonomic Imbalance and 24-h Blood Pressure Change in Patients With Chronic Renal Disease
May 8, 2007 updated by: Yokohama City University Medical Center
Many patients with chronic renal disease show a loss of the nocturnal decline of blood pressure (non-dipper).
However, the mechanism is not yet fully understood.
We evaluate 24-hour blood pressure in patients with chronic renal disease using an ambulatory blood pressure monitoring device (A & D TM2425).
We also analyze the power spectrum of heart rate variability as an index of autonomic cardiovascular modulation using the same device.
Study Overview
Status
Completed
Intervention / Treatment
Detailed Description
The ratio of lower frequency (LF) and higher frequency (HF) heart rate rhythmic oscillations is expressed as an index of sympathovagal balance.
Patients with chronic renal disease participate in the study.
Blood pressure and power spectrum of heart rate variability for 24 hours are measured when they receive no medication for at least 1 week.
The mean waking and sleeping time systolic and diastolic blood pressure are calculated.
LF/HF ratios in the chronic renal disease are evaluated to calculate the waking/sleeping ratio for LF/HF.
Study Type
Observational
Enrollment (Actual)
278
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Yokohama, Japan, 232-0024
- Yokohama City University Center Hospital
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
20 years to 85 years (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Hypertensive patients with diabetes mellitus
- Hypertensive patients
- Hypertensive patients with renal disease
- Patients with chronic renal disease
Exclusion Criteria:
- Cardiac, hematologic or hepatic disease
- Cerebral infarction or hemorrhage
- Other major diseases.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Publications and helpful links
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Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
February 1, 2004
Study Completion (Actual)
December 1, 2006
Study Registration Dates
First Submitted
February 28, 2006
First Submitted That Met QC Criteria
February 28, 2006
First Posted (Estimate)
March 1, 2006
Study Record Updates
Last Update Posted (Estimate)
May 9, 2007
Last Update Submitted That Met QC Criteria
May 8, 2007
Last Verified
May 1, 2007
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 7332-3
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