Molecular Epidemiology of Benzene-exposed Workers.

May 19, 2015 updated by: University of Colorado, Denver

Molecular Epidemiology of Benzene-exposed Workers in Shanghai,China

The purpose of this study is to investigate the health effects of benzene exposure in workers in Shanghai, China.

Study Overview

Status

Completed

Intervention / Treatment

Detailed Description

The purpose of this study is to investigate the dose-response relationship between benzene exposure and blood diseases in Shanghai workers and to characterize genetic polymorphisms that are associated with increased risk of developing benzene hematotoxicity.

Study Type

Observational

Enrollment (Actual)

2000

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

      • Shanghai, China, 200032
        • Joint Sino-US Clinical and Molecular Laboratory (JCML)

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 67 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Shanghai Workers

Description

Inclusion Criteria:

Worked for at least one year in a monitored environment Have at least one physical examination recorded

-

Exclusion Criteria:

History of cancer, radiation exposure, chemotherapy

-

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Ecologic or Community
  • Time Perspectives: Cross-Sectional

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Shanghai Workers

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Investigate the dose-response relationship between benzene exposure and blood diseases in Shanghai workers.
Time Frame: August 2003 - December 2009
Investigate the dose-response relationship between benzene exposure and blood diseases in Shanghai workers
August 2003 - December 2009

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Characterize genetic polymorphisms that are associated with increased risk of developing benzene hematotoxicity.
Time Frame: August 2003 - December 2009
Characterize genetic polymorphisms that are associated with increased risk of developing benzene hematotoxicity.
August 2003 - December 2009

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Investigators

  • Principal Investigator: Richard D Irons, PhD, University of Colorado at Denver and Health Sciences Ctr

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

August 1, 2003

Primary Completion (Actual)

December 1, 2009

Study Completion (Actual)

December 1, 2009

Study Registration Dates

First Submitted

August 14, 2006

First Submitted That Met QC Criteria

August 14, 2006

First Posted (Estimate)

August 15, 2006

Study Record Updates

Last Update Posted (Estimate)

May 21, 2015

Last Update Submitted That Met QC Criteria

May 19, 2015

Last Verified

May 1, 2007

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 02-0037

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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