GI-Reasons- A Trial Of GI Safety Of Celecoxib Compared With Non-Selective Nonsteroidal Antiinflammatory Drugs (NSAIDS) (GI-REASONS)

March 1, 2021 updated by: Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Gastrointestinal (GI) Randomized Event And Safety Open-Label NSAID Study (GI-Reasons): A Randomized, Open-Label, Blinded-Endpoint, Parallel-Group Trial Of GI Safety Of Celecoxib Compared With Non-Selective Nonsteroidal Antiinflammatory Drugs (NSAIDS) In Osteoarthritis Patients

This study investigates if Celebrex has a lower incident of Gastrointestinal Events than other NSAIDS in subjects with osteoarthritis.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

8067

Phase

  • Phase 4

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Puerto Rico
      • Aguas Buenas, Puerto Rico, 00703
        • Pfizer Investigational Site
      • Aguns Buenoas, Puerto Rico, 00703
        • Pfizer Investigational Site
      • Aibonito, Puerto Rico, 00705
        • Pfizer Investigational Site
      • Bayamon, Puerto Rico, 00956
        • Pfizer Investigational Site
      • Bayamon, Puerto Rico, 00959
        • Pfizer Investigational Site
      • Caguas, Puerto Rico, 00725
        • Pfizer Investigational Site
      • Carolina, Puerto Rico, 00983
        • Pfizer Investigational Site
      • Cayey, Puerto Rico, 00736
        • Pfizer Investigational Site
      • Cialis, Puerto Rico, 00638
        • Pfizer Investigational Site
      • Cidra, Puerto Rico, 00739
        • Pfizer Investigational Site
      • Hato Rey, Puerto Rico, 00918
        • Pfizer Investigational Site
      • Juncas, Puerto Rico, 00777
        • Pfizer Investigational Site
      • Juncos, Puerto Rico, 00777
        • Pfizer Investigational Site
      • Las Piedras, Puerto Rico, 00771
        • Pfizer Investigational Site
      • Levittown, Puerto Rico, 00949
        • Pfizer Investigational Site
      • Loiza, Puerto Rico, 00772
        • Pfizer Investigational Site
      • Manati, Puerto Rico, 00674
        • Pfizer Investigational Site
      • Orocovis, Puerto Rico, 00720
        • Pfizer Investigational Site
      • Rio Piedras, Puerto Rico, 00921
        • Pfizer Investigational Site
      • Rio Piedras, Puerto Rico, 00926
        • Pfizer Investigational Site
      • San Juan, Puerto Rico, 00915
        • Pfizer Investigational Site
      • San Juan, Puerto Rico, 00921-1308
        • Pfizer Investigational Site
      • San Juan, Puerto Rico, 00924
        • Pfizer Investigational Site
      • San Juan, Puerto Rico, 00927
        • Pfizer Investigational Site
      • Santa Isabel, Puerto Rico, 00757
        • Pfizer Investigational Site
      • Santurce, Puerto Rico, 00908
        • Pfizer Investigational Site
      • Trujillo Alto, Puerto Rico, 00976
        • Pfizer Investigational Site
  • United States
    • Alabama
      • Abbeville, Alabama, United States, 36310
        • Pfizer Investigational Site
      • Alexander City, Alabama, United States, 35010
        • Pfizer Investigational Site
      • Bay Minette, Alabama, United States, 36507-4185
        • Pfizer Investigational Site
      • Birmingham, Alabama, United States, 35209
        • Pfizer Investigational Site
      • Birmingham, Alabama, United States, 35205
        • Pfizer Investigational Site
      • Birmingham, Alabama, United States, 35215
        • Pfizer Investigational Site
      • Birmingham, Alabama, United States, 35235
        • Pfizer Investigational Site
      • Birmingham, Alabama, United States, 35218
        • Pfizer Investigational Site
      • Birmingham, Alabama, United States, 35244
        • Pfizer Investigational Site
      • Cullman, Alabama, United States, 35058
        • Pfizer Investigational Site
      • Dothan, Alabama, United States, 36303
        • Pfizer Investigational Site
      • Dothan, Alabama, United States, 36301
        • Pfizer Investigational Site
      • Geneva, Alabama, United States, 36340
        • Pfizer Investigational Site
      • Gulf Shores, Alabama, United States, 36547
        • Pfizer Investigational Site
      • Guntersville, Alabama, United States, 35976
        • Pfizer Investigational Site
      • Huntsville, Alabama, United States, 35801
        • Pfizer Investigational Site
      • Huntsville, Alabama, United States, 35824
        • Pfizer Investigational Site
      • Jacksonville, Alabama, United States, 36265
        • Pfizer Investigational Site
      • Mobile, Alabama, United States, 36604-1416
        • Pfizer Investigational Site
      • Montgomery, Alabama, United States, 36106
        • Pfizer Investigational Site
      • Muscle Shoals, Alabama, United States, 35662
        • Pfizer Investigational Site
      • Ozark, Alabama, United States, 36360
        • Pfizer Investigational Site
      • Pell City, Alabama, United States, 32515
        • Pfizer Investigational Site
      • Tallassee, Alabama, United States, 36078
        • Pfizer Investigational Site
    • Arizona
      • Chandler, Arizona, United States, 85224
        • Pfizer Investigational Site
      • Glendale, Arizona, United States, 85308
        • Pfizer Investigational Site
      • Green Valley, Arizona, United States, 85614
        • Pfizer Investigational Site
      • Mesa, Arizona, United States, 85206
        • Pfizer Investigational Site
      • Mesa, Arizona, United States, 85203
        • Pfizer Investigational Site
      • Phoenix, Arizona, United States, 85016
        • Pfizer Investigational Site
      • Phoenix, Arizona, United States, 85032
        • Pfizer Investigational Site
      • Phoenix, Arizona, United States, 85028
        • Pfizer Investigational Site
      • Phoenix, Arizona, United States, 85051
        • Pfizer Investigational Site
      • Phoenix, Arizona, United States, 85023
        • Pfizer Investigational Site
      • Scottsdale, Arizona, United States, 85258
        • Pfizer Investigational Site
      • Sierra Vista, Arizona, United States, 85635
        • Pfizer Investigational Site
      • Sun Lakes, Arizona, United States, 85248
        • Pfizer Investigational Site
      • Tempe, Arizona, United States, 85282
        • Pfizer Investigational Site
      • Tempe, Arizona, United States, 85283
        • Pfizer Investigational Site
      • Tucson, Arizona, United States, 85712
        • Pfizer Investigational Site
      • Tucson, Arizona, United States, 85719
        • Pfizer Investigational Site
    • Arkansas
      • Hot Springs, Arkansas, United States, 71913
        • Pfizer Investigational Site
      • Little Rock, Arkansas, United States, 72205
        • Pfizer Investigational Site
      • Paragould, Arkansas, United States, 72450
        • Pfizer Investigational Site
      • Pine Bluff, Arkansas, United States, 71603
        • Pfizer Investigational Site
    • California
      • Anaheim, California, United States, 92801
        • Pfizer Investigational Site
      • Anaheim, California, United States, 92804
        • Pfizer Investigational Site
      • Bakersfield, California, United States, 93309
        • Pfizer Investigational Site
      • Bellflower, California, United States, 90706
        • Pfizer Investigational Site
      • Bermuda Dunes, California, United States, 92203
        • Pfizer Investigational Site
      • Buena Park, California, United States, 90620
        • Pfizer Investigational Site
      • Buena Park, California, United States, 90620-3886
        • Pfizer Investigational Site
      • Carson, California, United States, 90745
        • Pfizer Investigational Site
      • Cerritos, California, United States, 90703
        • Pfizer Investigational Site
      • Chula Vista, California, United States, 91910
        • Pfizer Investigational Site
      • Cudahy, California, United States, 90201
        • Pfizer Investigational Site
      • El Cajon, California, United States, 92019
        • Pfizer Investigational Site
      • El Segundo, California, United States, 90245
        • Pfizer Investigational Site
      • Encino, California, United States, 91436
        • Pfizer Investigational Site
      • Escondido, California, United States, 92025-3406
        • Pfizer Investigational Site
      • Fortuna, California, United States, 95540
        • Pfizer Investigational Site
      • Fremont, California, United States, 94536
        • Pfizer Investigational Site
      • Fresno, California, United States, 93710
        • Pfizer Investigational Site
      • Fresno, California, United States, 93726
        • Pfizer Investigational Site
      • Garden Grove, California, United States, 92845
        • Pfizer Investigational Site
      • Garden Grove, California, United States, 92843
        • Pfizer Investigational Site
      • Greenbrae, California, United States, 94904
        • Pfizer Investigational Site
      • Harbor City, California, United States, 90710
        • Pfizer Investigational Site
      • Hemet, California, United States, 92543
        • Pfizer Investigational Site
      • Huntington Beach, California, United States, 92646
        • Pfizer Investigational Site
      • Huntington Park, California, United States, 90255
        • Pfizer Investigational Site
      • Irvine, California, United States, 92618
        • Pfizer Investigational Site
      • La Jolla, California, United States, 92037-1233
        • Pfizer Investigational Site
      • La Palma, California, United States, 90623
        • Pfizer Investigational Site
      • Long Beach, California, United States, 90806
        • Pfizer Investigational Site
      • Long Beach, California, United States, 90813
        • Pfizer Investigational Site
      • Long Beach, California, United States, 90807
        • Pfizer Investigational Site
      • Los Angeles, California, United States, 90025
        • Pfizer Investigational Site
      • Los Angeles, California, United States, 90017
        • Pfizer Investigational Site
      • Los Angeles, California, United States, 90026
        • Pfizer Investigational Site
      • Los Angeles, California, United States, 90041-2321
        • Pfizer Investigational Site
      • Los Banos, California, United States, 93635
        • Pfizer Investigational Site
      • Los Gatos, California, United States, 95032
        • Pfizer Investigational Site
      • Marina Del Rey, California, United States, 90292-5425
        • Pfizer Investigational Site
      • Merced, California, United States, 95340
        • Pfizer Investigational Site
      • Mission Viejo, California, United States, 92691
        • Pfizer Investigational Site
      • Montebello, California, United States, 90640
        • Pfizer Investigational Site
      • Monterey Park, California, United States, 91754
        • Pfizer Investigational Site
      • Newport Beach, California, United States, 92660
        • Pfizer Investigational Site
      • Newport Beach, California, United States, 92260
        • Pfizer Investigational Site
      • Paramount, California, United States, 90723
        • Pfizer Investigational Site
      • Pismo Beach, California, United States, 93449
        • Pfizer Investigational Site
      • Rancho Cucamonga, California, United States, 91730
        • Pfizer Investigational Site
      • Redlands, California, United States, 92374
        • Pfizer Investigational Site
      • Reseda, California, United States, 91335
        • Pfizer Investigational Site
      • Rialto, California, United States, 92376
        • Pfizer Investigational Site
      • Riverside, California, United States, 92506
        • Pfizer Investigational Site
      • Rowland Heights, California, United States, 91748
        • Pfizer Investigational Site
      • Sacramento, California, United States, 95823
        • Pfizer Investigational Site
      • San Diego, California, United States, 92108
        • Pfizer Investigational Site
      • San Diego, California, United States, 92120
        • Pfizer Investigational Site
      • San Diego, California, United States, 92117
        • Pfizer Investigational Site
      • San Diego, California, United States, 92101
        • Pfizer Investigational Site
      • San Francisco, California, United States, 94109
        • Pfizer Investigational Site
      • San Jose, California, United States, 95112
        • Pfizer Investigational Site
      • San Leandro, California, United States, 94578
        • Pfizer Investigational Site
      • Santa Ana, California, United States, 92704
        • Pfizer Investigational Site
      • Santa Ana, California, United States, 92701
        • Pfizer Investigational Site
      • Santa Maria, California, United States, 93454
        • Pfizer Investigational Site
      • Tarzana, California, United States, 91356
        • Pfizer Investigational Site
      • Torrance, California, United States, 90505
        • Pfizer Investigational Site
      • Tulare, California, United States, 93274
        • Pfizer Investigational Site
      • Upland, California, United States, 91786
        • Pfizer Investigational Site
      • Van Nuys, California, United States, 91405
        • Pfizer Investigational Site
      • Victorville, California, United States, 92392
        • Pfizer Investigational Site
      • Victorville, California, United States, 92395
        • Pfizer Investigational Site
      • West Covina, California, United States, 91790
        • Pfizer Investigational Site
      • Westminster, California, United States, 92683
        • Pfizer Investigational Site
      • Whittier, California, United States, 90606
        • Pfizer Investigational Site
      • Wildomar, California, United States, 92595
        • Pfizer Investigational Site
      • Wilmington, California, United States, 90744
        • Pfizer Investigational Site
      • Woodland Hills, California, United States, 91364
        • Pfizer Investigational Site
    • Colorado
      • Aurora, Colorado, United States, 80012
        • Pfizer Investigational Site
      • Colorado Springs, Colorado, United States, 80907
        • Pfizer Investigational Site
      • Colorado Springs, Colorado, United States, 80920
        • Pfizer Investigational Site
      • Denver, Colorado, United States, 80209
        • Pfizer Investigational Site
      • Denver, Colorado, United States, 80206
        • Pfizer Investigational Site
      • Denver, Colorado, United States, 80219
        • Pfizer Investigational Site
      • Fort Collins, Colorado, United States, 80525
        • Pfizer Investigational Site
      • Golden, Colorado, United States, 80401
        • Pfizer Investigational Site
      • Lakewood, Colorado, United States, 80214
        • Pfizer Investigational Site
      • Lakewood, Colorado, United States, 80226
        • Pfizer Investigational Site
      • Northglenn, Colorado, United States, 80234
        • Pfizer Investigational Site
      • Pueblo, Colorado, United States, 81001
        • Pfizer Investigational Site
    • Connecticut
      • Avon, Connecticut, United States, 06001
        • Pfizer Investigational Site
      • Brewster, Connecticut, United States, 06010
        • Pfizer Investigational Site
      • Brookfield, Connecticut, United States, 06804
        • Pfizer Investigational Site
      • Cos Cob, Connecticut, United States, 06807
        • Pfizer Investigational Site
      • Hamden, Connecticut, United States, 06518
        • Pfizer Investigational Site
      • Milford, Connecticut, United States, 06460
        • Pfizer Investigational Site
      • Ridgefield, Connecticut, United States, 06877
        • Pfizer Investigational Site
    • Delaware
      • Newark, Delaware, United States, 19713
        • Pfizer Investigational Site
      • Smyrna, Delaware, United States, 19977
        • Pfizer Investigational Site
      • Wilmington, Delaware, United States, 19805
        • Pfizer Investigational Site
    • District of Columbia
      • Washington, District of Columbia, United States, 20017
        • Pfizer Investigational Site
      • Washington, District of Columbia, United States, 20020
        • Pfizer Investigational Site
    • Florida
      • Altamonte Springs, Florida, United States, 32701-4810
        • Pfizer Investigational Site
      • Apopka, Florida, United States, 32703
        • Pfizer Investigational Site
      • Beverly Hills, Florida, United States, 34465
        • Pfizer Investigational Site
      • Boynton Beach, Florida, United States, 33437
        • Pfizer Investigational Site
      • Chipley, Florida, United States, 32428
        • Pfizer Investigational Site
      • Clearwater, Florida, United States, 33755
        • Pfizer Investigational Site
      • Clermont, Florida, United States, 34711
        • Pfizer Investigational Site
      • Cocoa, Florida, United States, 32927
        • Pfizer Investigational Site
      • Cocoa Beach, Florida, United States, 32931
        • Pfizer Investigational Site
      • Coral Springs, Florida, United States, 33065
        • Pfizer Investigational Site
      • Crystal River, Florida, United States, 34429
        • Pfizer Investigational Site
      • Cutler Bay, Florida, United States, 33189
        • Pfizer Investigational Site
      • Davie, Florida, United States, 33314
        • Pfizer Investigational Site
      • Daytona Beach, Florida, United States, 32114
        • Pfizer Investigational Site
      • Daytona Beach, Florida, United States, 32117
        • Pfizer Investigational Site
      • DeFuniak Springs, Florida, United States, 32435
        • Pfizer Investigational Site
      • DeLand, Florida, United States, 32720
        • Pfizer Investigational Site
      • Dunnellon, Florida, United States, 34432
        • Pfizer Investigational Site
      • Fort Lauderdale, Florida, United States, 33334
        • Pfizer Investigational Site
      • Fort Myers, Florida, United States, 33907
        • Pfizer Investigational Site
      • Gainesville, Florida, United States, 32605
        • Pfizer Investigational Site
      • Green Cove Springs, Florida, United States, 32043
        • Pfizer Investigational Site
      • Hallandale Beach, Florida, United States, 33009
        • Pfizer Investigational Site
      • Hialeah, Florida, United States, 33016
        • Pfizer Investigational Site
      • Hialeah, Florida, United States, 33013
        • Pfizer Investigational Site
      • Hialeah, Florida, United States, 33010
        • Pfizer Investigational Site
      • Hollywood, Florida, United States, 33021
        • Pfizer Investigational Site
      • Hollywood, Florida, United States, 33023
        • Pfizer Investigational Site
      • Jacksonville, Florida, United States, 32257
        • Pfizer Investigational Site
      • Jupiter, Florida, United States, 33458
        • Pfizer Investigational Site
      • Key Biscayne, Florida, United States, 33149
        • Pfizer Investigational Site
      • Kissimmee, Florida, United States, 34741
        • Pfizer Investigational Site
      • Lake Worth, Florida, United States, 33461
        • Pfizer Investigational Site
      • Largo, Florida, United States, 33770
        • Pfizer Investigational Site
      • Melbourne, Florida, United States, 32901
        • Pfizer Investigational Site
      • Melbourne, Florida, United States, 32935
        • Pfizer Investigational Site
      • Miami, Florida, United States, 33144
        • Pfizer Investigational Site
      • Miami, Florida, United States, 33176
        • Pfizer Investigational Site
      • Miami, Florida, United States, 33126
        • Pfizer Investigational Site
      • Miami, Florida, United States, 33186
        • Pfizer Investigational Site
      • Miami, Florida, United States, 33145
        • Pfizer Investigational Site
      • Miami, Florida, United States, 33155
        • Pfizer Investigational Site
      • Miami, Florida, United States, 33135
        • Pfizer Investigational Site
      • Miami, Florida, United States, 33157
        • Pfizer Investigational Site
      • Miami Beach, Florida, United States, 33139
        • Pfizer Investigational Site
      • Niceville, Florida, United States, 32578
        • Pfizer Investigational Site
      • North Miami, Florida, United States, 33161
        • Pfizer Investigational Site
      • Ocala, Florida, United States, 34474
        • Pfizer Investigational Site
      • Orange City, Florida, United States, 32763
        • Pfizer Investigational Site
      • Orlando, Florida, United States, 32804
        • Pfizer Investigational Site
      • Ormond Beach, Florida, United States, 32174
        • Pfizer Investigational Site
      • Oviedo, Florida, United States, 32765
        • Pfizer Investigational Site
      • Palm Bay, Florida, United States, 32907
        • Pfizer Investigational Site
      • Palm Harbor, Florida, United States, 34684
        • Pfizer Investigational Site
      • Panama City, Florida, United States, 32401
        • Pfizer Investigational Site
      • Parkland, Florida, United States, 33067
        • Pfizer Investigational Site
      • Pembroke Pines, Florida, United States, 33027
        • Pfizer Investigational Site
      • Pembroke Pines, Florida, United States, 33029
        • Pfizer Investigational Site
      • Pinecrest, Florida, United States, 33156
        • Pfizer Investigational Site
      • Plantation, Florida, United States, 33324
        • Pfizer Investigational Site
      • Plantation, Florida, United States, 33317
        • Pfizer Investigational Site
      • Port Charlotte, Florida, United States, 33952
        • Pfizer Investigational Site
      • Port Orange, Florida, United States, 32129
        • Pfizer Investigational Site
      • Port Richey, Florida, United States, 34668
        • Pfizer Investigational Site
      • Saint Cloud, Florida, United States, 34769
        • Pfizer Investigational Site
      • Saint Petersburg, Florida, United States, 33713
        • Pfizer Investigational Site
      • Saint Petersburg, Florida, United States, 33703
        • Pfizer Investigational Site
      • Sarasota, Florida, United States, 34239
        • Pfizer Investigational Site
      • Sebastian, Florida, United States, 32958-3296
        • Pfizer Investigational Site
      • South Miami, Florida, United States, 33143
        • Pfizer Investigational Site
      • Tallahassee, Florida, United States, 32301
        • Pfizer Investigational Site
      • Tampa, Florida, United States, 33624
        • Pfizer Investigational Site
      • Tampa, Florida, United States, 33614
        • Pfizer Investigational Site
      • Tampa, Florida, United States, 33613
        • Pfizer Investigational Site
      • Tampa, Florida, United States, 33607
        • Pfizer Investigational Site
      • Tampa, Florida, United States, 33615
        • Pfizer Investigational Site
      • Tampa, Florida, United States, 33619-6364
        • Pfizer Investigational Site
      • Vero Beach, Florida, United States, 32960
        • Pfizer Investigational Site
      • Wellington, Florida, United States, 33414
        • Pfizer Investigational Site
    • Georgia
      • Athens, Georgia, United States, 30606
        • Pfizer Investigational Site
      • Atlanta, Georgia, United States, 30338
        • Pfizer Investigational Site
      • Bainbridge, Georgia, United States, 39819
        • Pfizer Investigational Site
      • Cairo, Georgia, United States, 39829
        • Pfizer Investigational Site
      • Calhoun, Georgia, United States, 30701
        • Pfizer Investigational Site
      • Cartersville, Georgia, United States, 30120
        • Pfizer Investigational Site
      • Columbus, Georgia, United States, 31904
        • Pfizer Investigational Site
      • Covington, Georgia, United States, 30016
        • Pfizer Investigational Site
      • Cumming, Georgia, United States, 30041
        • Pfizer Investigational Site
      • Dawsonville, Georgia, United States, 30534
        • Pfizer Investigational Site
      • Decatur, Georgia, United States, 30033
        • Pfizer Investigational Site
      • Dunwoody, Georgia, United States, 30338
        • Pfizer Investigational Site
      • Gainesville, Georgia, United States, 30501
        • Pfizer Investigational Site
      • Hampton, Georgia, United States, 30228
        • Pfizer Investigational Site
      • Hinesville, Georgia, United States, 31313
        • Pfizer Investigational Site
      • Lawrenceville, Georgia, United States, 30045
        • Pfizer Investigational Site
      • Macon, Georgia, United States, 31206
        • Pfizer Investigational Site
      • Roswell, Georgia, United States, 30075
        • Pfizer Investigational Site
      • Sandersville, Georgia, United States, 31082
        • Pfizer Investigational Site
      • Savannah, Georgia, United States, 31406
        • Pfizer Investigational Site
      • Snellville, Georgia, United States, 30078
        • Pfizer Investigational Site
      • Stockbridge, Georgia, United States, 30281
        • Pfizer Investigational Site
      • Watkinsville, Georgia, United States, 30677
        • Pfizer Investigational Site
      • Waycross, Georgia, United States, 31501-1943
        • Pfizer Investigational Site
    • Hawaii
      • 'Aiea, Hawaii, United States, 96701
        • Pfizer Investigational Site
      • Honolulu, Hawaii, United States, 96814
        • Pfizer Investigational Site
      • Honolulu, Hawaii, United States, 96819
        • Pfizer Investigational Site
    • Illinois
      • Arlington Heights, Illinois, United States, 60004
        • Pfizer Investigational Site
      • Chicago, Illinois, United States, 60628
        • Pfizer Investigational Site
      • Danville, Illinois, United States, 61832
        • Pfizer Investigational Site
      • DeKalb, Illinois, United States, 60115
        • Pfizer Investigational Site
      • Elgin, Illinois, United States, 60123
        • Pfizer Investigational Site
      • Evergreen Park, Illinois, United States, 60805
        • Pfizer Investigational Site
      • Fairview Heights, Illinois, United States, 62208
        • Pfizer Investigational Site
      • Flossmoor, Illinois, United States, 60422
        • Pfizer Investigational Site
      • Greenville, Illinois, United States, 62246
        • Pfizer Investigational Site
      • Hanna City, Illinois, United States, 61536
        • Pfizer Investigational Site
      • Moline, Illinois, United States, 61265
        • Pfizer Investigational Site
      • Moweaqua, Illinois, United States, 62550
        • Pfizer Investigational Site
      • O'Fallon, Illinois, United States, 62269
        • Pfizer Investigational Site
      • Pekin, Illinois, United States, 61554-6096
        • Pfizer Investigational Site
      • Peoria, Illinois, United States, 61614
        • Pfizer Investigational Site
      • Peoria, Illinois, United States, 61602
        • Pfizer Investigational Site
      • Peoria, Illinois, United States, 61603-4301
        • Pfizer Investigational Site
      • Quincy, Illinois, United States, 62301
        • Pfizer Investigational Site
      • Watseka, Illinois, United States, 60970
        • Pfizer Investigational Site
    • Indiana
      • Brownsburg, Indiana, United States, 46112
        • Pfizer Investigational Site
      • Evansville, Indiana, United States, 47712
        • Pfizer Investigational Site
      • Evansville, Indiana, United States, 47710-3807
        • Pfizer Investigational Site
      • Fort Wayne, Indiana, United States, 46809
        • Pfizer Investigational Site
      • Hobart, Indiana, United States, 46342
        • Pfizer Investigational Site
      • Indianapolis, Indiana, United States, 46250
        • Pfizer Investigational Site
      • Indianapolis, Indiana, United States, 46205
        • Pfizer Investigational Site
      • Indianapolis, Indiana, United States, 46217
        • Pfizer Investigational Site
      • LaPorte, Indiana, United States, 46350
        • Pfizer Investigational Site
      • Mishawaka, Indiana, United States, 46545
        • Pfizer Investigational Site
      • New Haven, Indiana, United States, 46774
        • Pfizer Investigational Site
      • South Bend, Indiana, United States, 46601
        • Pfizer Investigational Site
      • South Bend, Indiana, United States, 46601-1071
        • Pfizer Investigational Site
      • Wabash, Indiana, United States, 46992
        • Pfizer Investigational Site
    • Iowa
      • Ames, Iowa, United States, 50010
        • Pfizer Investigational Site
      • Cedar Rapids, Iowa, United States, 52401
        • Pfizer Investigational Site
      • Des Moines, Iowa, United States, 50315
        • Pfizer Investigational Site
      • Des Moines, Iowa, United States, 50316
        • Pfizer Investigational Site
      • Dubuque, Iowa, United States, 52002
        • Pfizer Investigational Site
      • Fort Dodge, Iowa, United States, 50501
        • Pfizer Investigational Site
      • Waterloo, Iowa, United States, 50701
        • Pfizer Investigational Site
      • West Burlington, Iowa, United States, 52655
        • Pfizer Investigational Site
    • Kansas
      • Arkansas City, Kansas, United States, 67005
        • Pfizer Investigational Site
      • Kansas City, Kansas, United States, 66101
        • Pfizer Investigational Site
      • Kansas City, Kansas, United States, 66109
        • Pfizer Investigational Site
      • Mission, Kansas, United States, 66202-2722
        • Pfizer Investigational Site
      • Newton, Kansas, United States, 67114
        • Pfizer Investigational Site
      • Pratt, Kansas, United States, 67124
        • Pfizer Investigational Site
      • Shawnee Mission, Kansas, United States, 66203
        • Pfizer Investigational Site
      • Topeka, Kansas, United States, 66614
        • Pfizer Investigational Site
      • Wellington, Kansas, United States, 67152
        • Pfizer Investigational Site
      • Wichita, Kansas, United States, 67207
        • Pfizer Investigational Site
      • Wichita, Kansas, United States, 67205
        • Pfizer Investigational Site
    • Kentucky
      • Bowling Green, Kentucky, United States, 42104
        • Pfizer Investigational Site
      • Draffenville, Kentucky, United States, 42025
        • Pfizer Investigational Site
      • Hartford, Kentucky, United States, 42347
        • Pfizer Investigational Site
      • Lexington, Kentucky, United States, 40504
        • Pfizer Investigational Site
      • Louisville, Kentucky, United States, 40258
        • Pfizer Investigational Site
      • Mount Sterling, Kentucky, United States, 40353
        • Pfizer Investigational Site
      • Paducah, Kentucky, United States, 42003
        • Pfizer Investigational Site
      • Richmond, Kentucky, United States, 40475
        • Pfizer Investigational Site
    • Louisiana
      • Alexandria, Louisiana, United States, 71301
        • Pfizer Investigational Site
      • Baton Rouge, Louisiana, United States, 70806
        • Pfizer Investigational Site
      • Jena, Louisiana, United States, 71342
        • Pfizer Investigational Site
      • Jonesboro, Louisiana, United States, 71251
        • Pfizer Investigational Site
      • Lake Charles, Louisiana, United States, 70601
        • Pfizer Investigational Site
      • Metairie, Louisiana, United States, 70006
        • Pfizer Investigational Site
      • Monroe, Louisiana, United States, 71201
        • Pfizer Investigational Site
      • Monroe, Louisiana, United States, 71203
        • Pfizer Investigational Site
      • Natchitoches, Louisiana, United States, 71457
        • Pfizer Investigational Site
      • New Orleans, Louisiana, United States, 70115
        • Pfizer Investigational Site
      • Shreveport, Louisiana, United States, 71105
        • Pfizer Investigational Site
      • Shreveport, Louisiana, United States, 71106
        • Pfizer Investigational Site
    • Maryland
      • Baltimore, Maryland, United States, 21218
        • Pfizer Investigational Site
      • Baltimore, Maryland, United States, 21209
        • Pfizer Investigational Site
      • Baltimore, Maryland, United States, 21234-4607
        • Pfizer Investigational Site
      • Baltimore, Maryland, United States, 21286
        • Pfizer Investigational Site
      • Bel Air, Maryland, United States, 21015
        • Pfizer Investigational Site
      • Bladensburg, Maryland, United States, 20710
        • Pfizer Investigational Site
      • College Park, Maryland, United States, 20740
        • Pfizer Investigational Site
      • Elkton, Maryland, United States, 21921-5230
        • Pfizer Investigational Site
      • Ellicott City, Maryland, United States, 21042
        • Pfizer Investigational Site
      • Frederick, Maryland, United States, 21702
        • Pfizer Investigational Site
      • Mount Airy, Maryland, United States, 21771
        • Pfizer Investigational Site
      • Prince Frederick, Maryland, United States, 20678
        • Pfizer Investigational Site
      • Riverdale, Maryland, United States, 20737
        • Pfizer Investigational Site
      • Rockville, Maryland, United States, 20852
        • Pfizer Investigational Site
      • Rockville, Maryland, United States, 20854-2957
        • Pfizer Investigational Site
      • Silver Spring, Maryland, United States, 20901
        • Pfizer Investigational Site
      • Towson, Maryland, United States, 21286
        • Pfizer Investigational Site
      • Wheaton, Maryland, United States, 20902
        • Pfizer Investigational Site
    • Massachusetts
      • Attleboro, Massachusetts, United States, 02762
        • Pfizer Investigational Site
      • Fall River, Massachusetts, United States, 02720
        • Pfizer Investigational Site
      • North Andover, Massachusetts, United States, 01875
        • Pfizer Investigational Site
      • North Dartmouth, Massachusetts, United States, 02747
        • Pfizer Investigational Site
      • Taunton, Massachusetts, United States, 02780
        • Pfizer Investigational Site
    • Michigan
      • Berkley, Michigan, United States, 48072
        • Pfizer Investigational Site
      • Brighton, Michigan, United States, 48116
        • Pfizer Investigational Site
      • Cadillac, Michigan, United States, 49601
        • Pfizer Investigational Site
      • Chelsea, Michigan, United States, 48118
        • Pfizer Investigational Site
      • Clarkston, Michigan, United States, 48346
        • Pfizer Investigational Site
      • Detroit, Michigan, United States, 48221
        • Pfizer Investigational Site
      • Fair Haven, Michigan, United States, 48023
        • Pfizer Investigational Site
      • Fenton, Michigan, United States, 48430
        • Pfizer Investigational Site
      • Flint, Michigan, United States, 48507
        • Pfizer Investigational Site
      • Grand Ledge, Michigan, United States, 48837
        • Pfizer Investigational Site
      • Grand Rapids, Michigan, United States, 49546
        • Pfizer Investigational Site
      • Interlochen, Michigan, United States, 49643
        • Pfizer Investigational Site
      • Kalamazoo, Michigan, United States, 49009
        • Pfizer Investigational Site
      • Lansing, Michigan, United States, 48910
        • Pfizer Investigational Site
      • Lansing, Michigan, United States, 48917
        • Pfizer Investigational Site
      • Livonia, Michigan, United States, 48150
        • Pfizer Investigational Site
      • Parchment, Michigan, United States, 49004
        • Pfizer Investigational Site
      • Pigeon, Michigan, United States, 48755
        • Pfizer Investigational Site
      • Saginaw, Michigan, United States, 48602
        • Pfizer Investigational Site
      • Saint Clair Shores, Michigan, United States, 48081
        • Pfizer Investigational Site
      • Saint Joseph, Michigan, United States, 49085-8511
        • Pfizer Investigational Site
      • Southfield, Michigan, United States, 48034
        • Pfizer Investigational Site
      • Southfield, Michigan, United States, 48075
        • Pfizer Investigational Site
      • Southgate, Michigan, United States, 48195
        • Pfizer Investigational Site
      • Sterling Heights, Michigan, United States, 48310
        • Pfizer Investigational Site
      • Sturgis, Michigan, United States, 49091
        • Pfizer Investigational Site
      • Traverse City, Michigan, United States, 49684
        • Pfizer Investigational Site
      • Troy, Michigan, United States, 48085
        • Pfizer Investigational Site
      • Troy, Michigan, United States, 48084
        • Pfizer Investigational Site
      • West Branch, Michigan, United States, 48661
        • Pfizer Investigational Site
      • Ypsilanti, Michigan, United States, 48197
        • Pfizer Investigational Site
    • Mississippi
      • Belzoni, Mississippi, United States, 39038
        • Pfizer Investigational Site
      • Hattiesburg, Mississippi, United States, 39402
        • Pfizer Investigational Site
      • Jackson, Mississippi, United States, 39202
        • Pfizer Investigational Site
      • Jackson, Mississippi, United States, 39209
        • Pfizer Investigational Site
      • Jackson, Mississippi, United States, 39211
        • Pfizer Investigational Site
      • Magee, Mississippi, United States, 39111
        • Pfizer Investigational Site
      • Picayune, Mississippi, United States, 39466
        • Pfizer Investigational Site
      • Port Gibson, Mississippi, United States, 39150
        • Pfizer Investigational Site
      • Prentiss, Mississippi, United States, 39474
        • Pfizer Investigational Site
      • Sumrall, Mississippi, United States, 39482
        • Pfizer Investigational Site
    • Missouri
      • Florissant, Missouri, United States, 63033
        • Pfizer Investigational Site
      • Jackson, Missouri, United States, 63755
        • Pfizer Investigational Site
      • Jefferson City, Missouri, United States, 65109
        • Pfizer Investigational Site
      • Kansas City, Missouri, United States, 64114
        • Pfizer Investigational Site
      • Kansas City, Missouri, United States, 64158
        • Pfizer Investigational Site
      • Saint Louis, Missouri, United States, 63141
        • Pfizer Investigational Site
      • Saint Louis, Missouri, United States, 63139
        • Pfizer Investigational Site
      • Saint Peters, Missouri, United States, 63376
        • Pfizer Investigational Site
      • Springfield, Missouri, United States, 65804
        • Pfizer Investigational Site
    • Montana
      • Missoula, Montana, United States, 59804
        • Pfizer Investigational Site
    • Nebraska
      • Alliance, Nebraska, United States, 69301
        • Pfizer Investigational Site
      • Beatrice, Nebraska, United States, 68310
        • Pfizer Investigational Site
      • Broken Bow, Nebraska, United States, 68822
        • Pfizer Investigational Site
      • Fremont, Nebraska, United States, 68025
        • Pfizer Investigational Site
      • Grand Island, Nebraska, United States, 68803
        • Pfizer Investigational Site
      • Lincoln, Nebraska, United States, 68516
        • Pfizer Investigational Site
      • Lincoln, Nebraska, United States, 68526
        • Pfizer Investigational Site
      • McCook, Nebraska, United States, 69001
        • Pfizer Investigational Site
      • Omaha, Nebraska, United States, 68124
        • Pfizer Investigational Site
      • Omaha, Nebraska, United States, 68134
        • Pfizer Investigational Site
      • Omaha, Nebraska, United States, 68144
        • Pfizer Investigational Site
      • Omaha, Nebraska, United States, 68116-2004
        • Pfizer Investigational Site
    • Nevada
      • Incline Village, Nevada, United States, 89452
        • Pfizer Investigational Site
      • Las Vegas, Nevada, United States, 89128
        • Pfizer Investigational Site
      • Las Vegas, Nevada, United States, 89101
        • Pfizer Investigational Site
    • New Jersey
      • Belvidere, New Jersey, United States, 07823
        • Pfizer Investigational Site
      • Berlin, New Jersey, United States, 08009
        • Pfizer Investigational Site
      • Blackwood, New Jersey, United States, 08012
        • Pfizer Investigational Site
      • Bridgeport, New Jersey, United States, 08014
        • Pfizer Investigational Site
      • Bridgeton, New Jersey, United States, 08302
        • Pfizer Investigational Site
      • Clementon, New Jersey, United States, 08021
        • Pfizer Investigational Site
      • Egg Harbor Township, New Jersey, United States, 08234
        • Pfizer Investigational Site
      • Elizabeth, New Jersey, United States, 07202
        • Pfizer Investigational Site
      • Elizabeth, New Jersey, United States, 07201
        • Pfizer Investigational Site
      • Flanders, New Jersey, United States, 07836
        • Pfizer Investigational Site
      • Freehold, New Jersey, United States, 07728
        • Pfizer Investigational Site
      • Glendora, New Jersey, United States, 08029
        • Pfizer Investigational Site
      • Holmdel, New Jersey, United States, 07733
        • Pfizer Investigational Site
      • Lincoln Park, New Jersey, United States, 07035
        • Pfizer Investigational Site
      • Linden, New Jersey, United States, 07036
        • Pfizer Investigational Site
      • Midland Park, New Jersey, United States, 07432
        • Pfizer Investigational Site
      • North Arlington, New Jersey, United States, 07031
        • Pfizer Investigational Site
      • Passaic, New Jersey, United States, 07055
        • Pfizer Investigational Site
      • South Bound Brook, New Jersey, United States, 08880
        • Pfizer Investigational Site
      • Voorhees, New Jersey, United States, 08043
        • Pfizer Investigational Site
      • Whitehouse Station, New Jersey, United States, 08889
        • Pfizer Investigational Site
      • Wildwood Crest, New Jersey, United States, 08260
        • Pfizer Investigational Site
    • New Mexico
      • Albuquerque, New Mexico, United States, 87102
        • Pfizer Investigational Site
      • Albuquerque, New Mexico, United States, 87111
        • Pfizer Investigational Site
      • Los Alamos, New Mexico, United States, 87544
        • Pfizer Investigational Site
    • New York
      • Albany, New York, United States, 12206
        • Pfizer Investigational Site
      • Brooklyn, New York, United States, 11224
        • Pfizer Investigational Site
      • Brooklyn, New York, United States, 11203-2711
        • Pfizer Investigational Site
      • East Syracuse, New York, United States, 13057
        • Pfizer Investigational Site
      • Elmhurst, New York, United States, 11373
        • Pfizer Investigational Site
      • Far Rockaway, New York, United States, 11691
        • Pfizer Investigational Site
      • Fayetteville, New York, United States, 13066
        • Pfizer Investigational Site
      • Flushing, New York, United States, 11355-2642
        • Pfizer Investigational Site
      • Flushing, New York, United States, 11358
        • Pfizer Investigational Site
      • Forest Hills, New York, United States, 11375
        • Pfizer Investigational Site
      • Lake Success, New York, United States, 11042
        • Pfizer Investigational Site
      • Lewiston, New York, United States, 14092
        • Pfizer Investigational Site
      • Liverpool, New York, United States, 13088
        • Pfizer Investigational Site
      • New Hartford, New York, United States, 13413
        • Pfizer Investigational Site
      • New Windsor, New York, United States, 12553
        • Pfizer Investigational Site
      • New York, New York, United States, 10025
        • Pfizer Investigational Site
      • New York, New York, United States, 10004
        • Pfizer Investigational Site
      • Olean, New York, United States, 14760
        • Pfizer Investigational Site
      • Orchard Park, New York, United States, 14127
        • Pfizer Investigational Site
      • Plainview, New York, United States, 11803
        • Pfizer Investigational Site
      • Rye Brook, New York, United States, 10573
        • Pfizer Investigational Site
      • Salamanca, New York, United States, 14779
        • Pfizer Investigational Site
      • Syracuse, New York, United States, 13208
        • Pfizer Investigational Site
      • Tonawanda, New York, United States, 14150
        • Pfizer Investigational Site
      • Wantagh, New York, United States, 11793
        • Pfizer Investigational Site
      • Warsaw, New York, United States, 14569
        • Pfizer Investigational Site
      • West Babylon, New York, United States, 11702
        • Pfizer Investigational Site
      • Williamsville, New York, United States, 14221
        • Pfizer Investigational Site
    • North Carolina
      • Asheboro, North Carolina, United States, 27203
        • Pfizer Investigational Site
      • Boone, North Carolina, United States, 28607
        • Pfizer Investigational Site
      • Bunn, North Carolina, United States, 27508
        • Pfizer Investigational Site
      • Charlotte, North Carolina, United States, 28262
        • Pfizer Investigational Site
      • Charlotte, North Carolina, United States, 28210
        • Pfizer Investigational Site
      • Durham, North Carolina, United States, 27704
        • Pfizer Investigational Site
      • Elizabeth City, North Carolina, United States, 27909
        • Pfizer Investigational Site
      • Gastonia, North Carolina, United States, 28056
        • Pfizer Investigational Site
      • Greensboro, North Carolina, United States, 27401
        • Pfizer Investigational Site
      • Greenville, North Carolina, United States, 27834
        • Pfizer Investigational Site
      • Huntersville, North Carolina, United States, 28078
        • Pfizer Investigational Site
      • Jacksonville, North Carolina, United States, 28546
        • Pfizer Investigational Site
      • Kinston, North Carolina, United States, 28501
        • Pfizer Investigational Site
      • Lenoir, North Carolina, United States, 28645
        • Pfizer Investigational Site
      • Monroe, North Carolina, United States, 28112
        • Pfizer Investigational Site
      • New Bern, North Carolina, United States, 28562
        • Pfizer Investigational Site
      • Raleigh, North Carolina, United States, 27609
        • Pfizer Investigational Site
      • Raleigh, North Carolina, United States, 27610
        • Pfizer Investigational Site
      • Raleigh, North Carolina, United States, 27607-6475
        • Pfizer Investigational Site
      • Shelby, North Carolina, United States, 28150
        • Pfizer Investigational Site
      • Statesville, North Carolina, United States, 28625
        • Pfizer Investigational Site
      • Tabor City, North Carolina, United States, 28463
        • Pfizer Investigational Site
      • Winston-Salem, North Carolina, United States, 27103
        • Pfizer Investigational Site
    • Ohio
      • Akron, Ohio, United States, 44310-1453
        • Pfizer Investigational Site
      • Boardman, Ohio, United States, 44512
        • Pfizer Investigational Site
      • Canton, Ohio, United States, 44708
        • Pfizer Investigational Site
      • Carlisle, Ohio, United States, 45005
        • Pfizer Investigational Site
      • Centerville, Ohio, United States, 45459
        • Pfizer Investigational Site
      • Chardon, Ohio, United States, 44024
        • Pfizer Investigational Site
      • Chesterland, Ohio, United States, 44026
        • Pfizer Investigational Site
      • Cincinnati, Ohio, United States, 45242
        • Pfizer Investigational Site
      • Cincinnati, Ohio, United States, 45236
        • Pfizer Investigational Site
      • Cincinnati, Ohio, United States, 45224
        • Pfizer Investigational Site
      • Cleveland, Ohio, United States, 44103
        • Pfizer Investigational Site
      • Columbus, Ohio, United States, 43207
        • Pfizer Investigational Site
      • Columbus, Ohio, United States, 43215
        • Pfizer Investigational Site
      • Columbus, Ohio, United States, 43212
        • Pfizer Investigational Site
      • Columbus, Ohio, United States, 43213
        • Pfizer Investigational Site
      • Columbus, Ohio, United States, 43230-8703
        • Pfizer Investigational Site
      • Cortland, Ohio, United States, 44410
        • Pfizer Investigational Site
      • Dayton, Ohio, United States, 45458
        • Pfizer Investigational Site
      • Delaware, Ohio, United States, 43015
        • Pfizer Investigational Site
      • Fairborn, Ohio, United States, 45324
        • Pfizer Investigational Site
      • Franklin, Ohio, United States, 45005
        • Pfizer Investigational Site
      • Genoa, Ohio, United States, 43430
        • Pfizer Investigational Site
      • Lyndhurst, Ohio, United States, 44124
        • Pfizer Investigational Site
      • Marietta, Ohio, United States, 45750
        • Pfizer Investigational Site
      • Marion, Ohio, United States, 43302
        • Pfizer Investigational Site
      • Mason, Ohio, United States, 45640
        • Pfizer Investigational Site
      • McConnelsville, Ohio, United States, 43756
        • Pfizer Investigational Site
      • Middleburg Heights, Ohio, United States, 44130
        • Pfizer Investigational Site
      • Middletown, Ohio, United States, 45044
        • Pfizer Investigational Site
      • New Lexington, Ohio, United States, 43764
        • Pfizer Investigational Site
      • Orrville, Ohio, United States, 44667
        • Pfizer Investigational Site
      • Shaker Heights, Ohio, United States, 44120
        • Pfizer Investigational Site
      • Toledo, Ohio, United States, 43606
        • Pfizer Investigational Site
      • Toledo, Ohio, United States, 43615
        • Pfizer Investigational Site
      • Trenton, Ohio, United States, 45067
        • Pfizer Investigational Site
      • Wadsworth, Ohio, United States, 44281
        • Pfizer Investigational Site
      • Warren, Ohio, United States, 44485
        • Pfizer Investigational Site
      • Westlake, Ohio, United States, 44145
        • Pfizer Investigational Site
      • Willoughby Hills, Ohio, United States, 44094
        • Pfizer Investigational Site
      • Wooster, Ohio, United States, 44691
        • Pfizer Investigational Site
      • Zanesville, Ohio, United States, 43701
        • Pfizer Investigational Site
    • Oklahoma
      • Bethany, Oklahoma, United States, 73008
        • Pfizer Investigational Site
      • Edmond, Oklahoma, United States, 73034
        • Pfizer Investigational Site
      • Moore, Oklahoma, United States, 73160
        • Pfizer Investigational Site
      • Oklahoma City, Oklahoma, United States, 73134
        • Pfizer Investigational Site
      • Stillwater, Oklahoma, United States, 74074
        • Pfizer Investigational Site
      • Tulsa, Oklahoma, United States, 74114
        • Pfizer Investigational Site
      • Yukon, Oklahoma, United States, 73099
        • Pfizer Investigational Site
    • Oregon
      • Grants Pass, Oregon, United States, 97526
        • Pfizer Investigational Site
      • Hermiston, Oregon, United States, 97838
        • Pfizer Investigational Site
      • Medford, Oregon, United States, 97504
        • Pfizer Investigational Site
      • Portland, Oregon, United States, 97219
        • Pfizer Investigational Site
      • Portland, Oregon, United States, 97227
        • Pfizer Investigational Site
    • Pennsylvania
      • Aston, Pennsylvania, United States, 19014
        • Pfizer Investigational Site
      • Audubon, Pennsylvania, United States, 19403
        • Pfizer Investigational Site
      • Bensalem, Pennsylvania, United States, 19020
        • Pfizer Investigational Site
      • Bethlehem, Pennsylvania, United States, 18015
        • Pfizer Investigational Site
      • Bristol, Pennsylvania, United States, 19007
        • Pfizer Investigational Site
      • Broomall, Pennsylvania, United States, 19008
        • Pfizer Investigational Site
      • Butler, Pennsylvania, United States, 16001
        • Pfizer Investigational Site
      • Camp Hill, Pennsylvania, United States, 17011
        • Pfizer Investigational Site
      • Carnegie, Pennsylvania, United States, 15106
        • Pfizer Investigational Site
      • Chester, Pennsylvania, United States, 19013
        • Pfizer Investigational Site
      • Chicora, Pennsylvania, United States, 16025
        • Pfizer Investigational Site
      • Cresson, Pennsylvania, United States, 16630
        • Pfizer Investigational Site
      • Dallastown, Pennsylvania, United States, 17313
        • Pfizer Investigational Site
      • Dauphin, Pennsylvania, United States, 17018
        • Pfizer Investigational Site
      • Downingtown, Pennsylvania, United States, 19335
        • Pfizer Investigational Site
      • Duncansville, Pennsylvania, United States, 16635
        • Pfizer Investigational Site
      • Erie, Pennsylvania, United States, 16504
        • Pfizer Investigational Site
      • Erie, Pennsylvania, United States, 16508-1256
        • Pfizer Investigational Site
      • Fleetwood, Pennsylvania, United States, 19522
        • Pfizer Investigational Site
      • Flourtown, Pennsylvania, United States, 19301
        • Pfizer Investigational Site
      • Fogelsville, Pennsylvania, United States, 18051
        • Pfizer Investigational Site
      • Greensburg, Pennsylvania, United States, 15601
        • Pfizer Investigational Site
      • Harrisburg, Pennsylvania, United States, 17112
        • Pfizer Investigational Site
      • Harrisburg, Pennsylvania, United States, 17111
        • Pfizer Investigational Site
      • Hatboro, Pennsylvania, United States, 19040
        • Pfizer Investigational Site
      • Hatfield, Pennsylvania, United States, 19440
        • Pfizer Investigational Site
      • Jeannette, Pennsylvania, United States, 15644
        • Pfizer Investigational Site
      • Jefferson Hills, Pennsylvania, United States, 15025
        • Pfizer Investigational Site
      • Johnstown, Pennsylvania, United States, 15901
        • Pfizer Investigational Site
      • King Of Prussia, Pennsylvania, United States, 19406
        • Pfizer Investigational Site
      • Lancaster, Pennsylvania, United States, 17601
        • Pfizer Investigational Site
      • Lansdale, Pennsylvania, United States, 19446
        • Pfizer Investigational Site
      • Lansdale, Pennsylvania, United States, 19446-1004
        • Pfizer Investigational Site
      • Millvale, Pennsylvania, United States, 15209
        • Pfizer Investigational Site
      • Morrisville, Pennsylvania, United States, 19067
        • Pfizer Investigational Site
      • Northern Cambria, Pennsylvania, United States, 15714
        • Pfizer Investigational Site
      • Penndel, Pennsylvania, United States, 19047
        • Pfizer Investigational Site
      • Pennsburg, Pennsylvania, United States, 18073
        • Pfizer Investigational Site
      • Philadelphia, Pennsylvania, United States, 19153-2326
        • Pfizer Investigational Site
      • Philadelphia, Pennsylvania, United States, 19152
        • Pfizer Investigational Site
      • Philadelphia, Pennsylvania, United States, 19124
        • Pfizer Investigational Site
      • Philadelphia, Pennsylvania, United States, 19138
        • Pfizer Investigational Site
      • Philadelphia, Pennsylvania, United States, 19148-2115
        • Pfizer Investigational Site
      • Phoenixville, Pennsylvania, United States, 19460
        • Pfizer Investigational Site
      • Pittsburgh, Pennsylvania, United States, 15243
        • Pfizer Investigational Site
      • Port Carbon, Pennsylvania, United States, 17965
        • Pfizer Investigational Site
      • Pottstown, Pennsylvania, United States, 19464
        • Pfizer Investigational Site
      • Reading, Pennsylvania, United States, 19606
        • Pfizer Investigational Site
      • Scranton, Pennsylvania, United States, 18510
        • Pfizer Investigational Site
      • Thorndale, Pennsylvania, United States, 19372
        • Pfizer Investigational Site
      • Tipton, Pennsylvania, United States, 16684
        • Pfizer Investigational Site
      • Uniontown, Pennsylvania, United States, 15401
        • Pfizer Investigational Site
      • Upper Saint Clair, Pennsylvania, United States, 15241
        • Pfizer Investigational Site
      • Wexford, Pennsylvania, United States, 15090-8405
        • Pfizer Investigational Site
      • Zionsville, Pennsylvania, United States, 18092
        • Pfizer Investigational Site
    • Rhode Island
      • Cranston, Rhode Island, United States, 02920
        • Pfizer Investigational Site
      • East Providence, Rhode Island, United States, 02914
        • Pfizer Investigational Site
      • Providence, Rhode Island, United States, 02906
        • Pfizer Investigational Site
      • Warwick, Rhode Island, United States, 02888
        • Pfizer Investigational Site
    • South Carolina
      • Anderson, South Carolina, United States, 29621
        • Pfizer Investigational Site
      • Bluffton, South Carolina, United States, 29910
        • Pfizer Investigational Site
      • Charleston, South Carolina, United States, 29414
        • Pfizer Investigational Site
      • Clemson, South Carolina, United States, 29631
        • Pfizer Investigational Site
      • Clinton, South Carolina, United States, 29325
        • Pfizer Investigational Site
      • Columbia, South Carolina, United States, 29204
        • Pfizer Investigational Site
      • Gaffney, South Carolina, United States, 29340
        • Pfizer Investigational Site
      • Greenville, South Carolina, United States, 29615
        • Pfizer Investigational Site
      • Greenville, South Carolina, United States, 29605
        • Pfizer Investigational Site
      • Greenville, South Carolina, United States, 29601
        • Pfizer Investigational Site
      • Greenville, South Carolina, United States, 29601-3973
        • Pfizer Investigational Site
      • Greer, South Carolina, United States, 29651
        • Pfizer Investigational Site
      • Landrum, South Carolina, United States, 29356
        • Pfizer Investigational Site
      • Marion, South Carolina, United States, 29571
        • Pfizer Investigational Site
      • Myrtle Beach, South Carolina, United States, 29572
        • Pfizer Investigational Site
      • Newberry, South Carolina, United States, 29108
        • Pfizer Investigational Site
      • North Myrtle Beach, South Carolina, United States, 29582
        • Pfizer Investigational Site
      • Orangeburg, South Carolina, United States, 29118
        • Pfizer Investigational Site
      • Orangeburg, South Carolina, United States, 29115
        • Pfizer Investigational Site
      • Peak, South Carolina, United States, 29122
        • Pfizer Investigational Site
      • Simpsonville, South Carolina, United States, 29681
        • Pfizer Investigational Site
      • Spartanburg, South Carolina, United States, 29303
        • Pfizer Investigational Site
      • Taylors, South Carolina, United States, 29687
        • Pfizer Investigational Site
      • Union, South Carolina, United States, 29379
        • Pfizer Investigational Site
    • Tennessee
      • Bolivar, Tennessee, United States, 38008
        • Pfizer Investigational Site
      • Chattanooga, Tennessee, United States, 37421
        • Pfizer Investigational Site
      • Clarksville, Tennessee, United States, 37043
        • Pfizer Investigational Site
      • Collierville, Tennessee, United States, 38017
        • Pfizer Investigational Site
      • Germantown, Tennessee, United States, 38138
        • Pfizer Investigational Site
      • Hendersonville, Tennessee, United States, 37075
        • Pfizer Investigational Site
      • Humboldt, Tennessee, United States, 38343
        • Pfizer Investigational Site
      • Kingsport, Tennessee, United States, 37660
        • Pfizer Investigational Site
      • Maynardville, Tennessee, United States, 37807
        • Pfizer Investigational Site
      • Memphis, Tennessee, United States, 38125
        • Pfizer Investigational Site
      • Morristown, Tennessee, United States, 37813
        • Pfizer Investigational Site
      • Nashville, Tennessee, United States, 37203
        • Pfizer Investigational Site
      • Nashville, Tennessee, United States, 37205
        • Pfizer Investigational Site
      • New Tazewell, Tennessee, United States, 37825
        • Pfizer Investigational Site
      • Springfield, Tennessee, United States, 37172
        • Pfizer Investigational Site
    • Texas
      • Amarillo, Texas, United States, 79106
        • Pfizer Investigational Site
      • Arlington, Texas, United States, 76017
        • Pfizer Investigational Site
      • Austin, Texas, United States, 78705
        • Pfizer Investigational Site
      • Austin, Texas, United States, 78750
        • Pfizer Investigational Site
      • Azle, Texas, United States, 76020
        • Pfizer Investigational Site
      • Carrollton, Texas, United States, 75007
        • Pfizer Investigational Site
      • Carrollton, Texas, United States, 75010
        • Pfizer Investigational Site
      • Colleyville, Texas, United States, 76034
        • Pfizer Investigational Site
      • Corpus Christi, Texas, United States, 78404
        • Pfizer Investigational Site
      • Dallas, Texas, United States, 75231
        • Pfizer Investigational Site
      • Dallas, Texas, United States, 75208
        • Pfizer Investigational Site
      • Dallas, Texas, United States, 75220
        • Pfizer Investigational Site
      • Dallas, Texas, United States, 75224
        • Pfizer Investigational Site
      • DeSoto, Texas, United States, 75115
        • Pfizer Investigational Site
      • Farmers Branch, Texas, United States, 75234
        • Pfizer Investigational Site
      • Fort Worth, Texas, United States, 76104
        • Pfizer Investigational Site
      • Fort Worth, Texas, United States, 76106
        • Pfizer Investigational Site
      • Fort Worth, Texas, United States, 76109
        • Pfizer Investigational Site
      • Fort Worth, Texas, United States, 76116
        • Pfizer Investigational Site
      • Fort Worth, Texas, United States, 76137
        • Pfizer Investigational Site
      • Frisco, Texas, United States, 75034
        • Pfizer Investigational Site
      • Garland, Texas, United States, 75043
        • Pfizer Investigational Site
      • Grand Prairie, Texas, United States, 75050
        • Pfizer Investigational Site
      • Grand Prairie, Texas, United States, 75052
        • Pfizer Investigational Site
      • Grapevine, Texas, United States, 76051
        • Pfizer Investigational Site
      • Henderson, Texas, United States, 75652
        • Pfizer Investigational Site
      • Houston, Texas, United States, 77024
        • Pfizer Investigational Site
      • Houston, Texas, United States, 77055
        • Pfizer Investigational Site
      • Houston, Texas, United States, 77008
        • Pfizer Investigational Site
      • Houston, Texas, United States, 77074
        • Pfizer Investigational Site
      • Houston, Texas, United States, 77034
        • Pfizer Investigational Site
      • Houston, Texas, United States, 77090
        • Pfizer Investigational Site
      • Houston, Texas, United States, 77004
        • Pfizer Investigational Site
      • Houston, Texas, United States, 77057
        • Pfizer Investigational Site
      • Houston, Texas, United States, 77070
        • Pfizer Investigational Site
      • Houston, Texas, United States, 77082
        • Pfizer Investigational Site
      • Houston, Texas, United States, 77088
        • Pfizer Investigational Site
      • Houston, Texas, United States, 77089
        • Pfizer Investigational Site
      • Humble, Texas, United States, 77338
        • Pfizer Investigational Site
      • Hurst, Texas, United States, 76054
        • Pfizer Investigational Site
      • Irving, Texas, United States, 75061
        • Pfizer Investigational Site
      • Irving, Texas, United States, 75039
        • Pfizer Investigational Site
      • Katy, Texas, United States, 77450
        • Pfizer Investigational Site
      • Killeen, Texas, United States, 76543
        • Pfizer Investigational Site
      • McKinney, Texas, United States, 75069
        • Pfizer Investigational Site
      • McKinney, Texas, United States, 75071
        • Pfizer Investigational Site
      • Midland, Texas, United States, 79705
        • Pfizer Investigational Site
      • Missouri City, Texas, United States, 77459
        • Pfizer Investigational Site
      • Nederland, Texas, United States, 77627
        • Pfizer Investigational Site
      • New Braunfels, Texas, United States, 78130
        • Pfizer Investigational Site
      • North Richland Hills, Texas, United States, 76180
        • Pfizer Investigational Site
      • Odessa, Texas, United States, 79761
        • Pfizer Investigational Site
      • Plano, Texas, United States, 75093
        • Pfizer Investigational Site
      • Plano, Texas, United States, 75075
        • Pfizer Investigational Site
      • Plano, Texas, United States, 75024
        • Pfizer Investigational Site
      • Pleasanton, Texas, United States, 78064
        • Pfizer Investigational Site
      • Poteet, Texas, United States, 78065
        • Pfizer Investigational Site
      • Richardson, Texas, United States, 75080
        • Pfizer Investigational Site
      • Richmond, Texas, United States, 77469
        • Pfizer Investigational Site
      • Rockwall, Texas, United States, 75032
        • Pfizer Investigational Site
      • San Antonio, Texas, United States, 78229
        • Pfizer Investigational Site
      • San Antonio, Texas, United States, 78258
        • Pfizer Investigational Site
      • San Antonio, Texas, United States, 78205
        • Pfizer Investigational Site
      • San Antonio, Texas, United States, 78224
        • Pfizer Investigational Site
      • San Antonio, Texas, United States, 78212
        • Pfizer Investigational Site
      • San Antonio, Texas, United States, 78230
        • Pfizer Investigational Site
      • San Marcos, Texas, United States, 78666
        • Pfizer Investigational Site
      • Seguin, Texas, United States, 78155
        • Pfizer Investigational Site
      • Southlake, Texas, United States, 76092
        • Pfizer Investigational Site
      • Spring, Texas, United States, 77386
        • Pfizer Investigational Site
      • Stephenville, Texas, United States, 76401
        • Pfizer Investigational Site
      • Sugar Land, Texas, United States, 77479
        • Pfizer Investigational Site
      • Sugar Land, Texas, United States, 77478
        • Pfizer Investigational Site
      • Sulphur Springs, Texas, United States, 75482
        • Pfizer Investigational Site
      • The Woodlands, Texas, United States, 77381-3528
        • Pfizer Investigational Site
      • Tomball, Texas, United States, 77375-4551
        • Pfizer Investigational Site
      • Tomball, Texas, United States, 77375
        • Pfizer Investigational Site
      • Waco, Texas, United States, 76708
        • Pfizer Investigational Site
      • Webster, Texas, United States, 77598
        • Pfizer Investigational Site
      • Wichita Falls, Texas, United States, 76309
        • Pfizer Investigational Site
    • Utah
      • Bountiful, Utah, United States, 84010
        • Pfizer Investigational Site
      • Clinton, Utah, United States, 84015-8324
        • Pfizer Investigational Site
      • Layton, Utah, United States, 84041
        • Pfizer Investigational Site
      • Saint George, Utah, United States, 84790
        • Pfizer Investigational Site
      • Salt Lake City, Utah, United States, 84124
        • Pfizer Investigational Site
      • Salt Lake City, Utah, United States, 84102
        • Pfizer Investigational Site
      • West Jordan, Utah, United States, 84088
        • Pfizer Investigational Site
    • Virginia
      • Annandale, Virginia, United States, 22003
        • Pfizer Investigational Site
      • Bluefield, Virginia, United States, 24605
        • Pfizer Investigational Site
      • Chatham, Virginia, United States, 24531
        • Pfizer Investigational Site
      • Chesapeake, Virginia, United States, 23320
        • Pfizer Investigational Site
      • Danville, Virginia, United States, 24541
        • Pfizer Investigational Site
      • Hampton, Virginia, United States, 23666
        • Pfizer Investigational Site
      • Honaker, Virginia, United States, 24260
        • Pfizer Investigational Site
      • Leesburg, Virginia, United States, 20175
        • Pfizer Investigational Site
      • Norfolk, Virginia, United States, 23502
        • Pfizer Investigational Site
      • Portsmouth, Virginia, United States, 23701
        • Pfizer Investigational Site
      • Richmond, Virginia, United States, 23219
        • Pfizer Investigational Site
      • Vienna, Virginia, United States, 22182
        • Pfizer Investigational Site
      • Virginia Beach, Virginia, United States, 23452
        • Pfizer Investigational Site
    • Washington
      • Bellevue, Washington, United States, 98004
        • Pfizer Investigational Site
      • Pasco, Washington, United States, 99301
        • Pfizer Investigational Site
      • Selah, Washington, United States, 98942
        • Pfizer Investigational Site
      • Spokane, Washington, United States, 99204
        • Pfizer Investigational Site
      • Spokane, Washington, United States, 99216
        • Pfizer Investigational Site
      • Tacoma, Washington, United States, 98405
        • Pfizer Investigational Site
      • Walla Walla, Washington, United States, 99362
        • Pfizer Investigational Site
    • West Virginia
      • Burnsville, West Virginia, United States, 26335
        • Pfizer Investigational Site
      • Lewisburg, West Virginia, United States, 24901
        • Pfizer Investigational Site
      • Ronceverte, West Virginia, United States, 24970
        • Pfizer Investigational Site

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

55 years to 99 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Male or female patients of at least 55 years of age with a clinical diagnosis of OA who are expected to require daily prescription anti-inflammatory analgesic therapy for arthritis symptom management and for whom either celecoxib or a nsNSAID is an appropriate treatment option.

Exclusion Criteria:

  • GI ulcer hemorrhage or active GD ulceration less than 90 days prior to screening visit.
  • Patients with a history of myocardial infarction, unstable angina, ischemic or hemorrhagic stroke, transient ischemic attack, previous revascularization procedure to coronary, carotid, cerebral, renal, aortic or peripheral arterial vasculature.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Celecoxib
dosing as per USPI label
Drug: Celecoxib
open-label
Active Comparator: NSAIDs
Drug: Any commercially available NSAID with the indication for osteoarthritis
dosing as per USPI label related to the chosen commercially marketed NSAID

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Percentage of Participants With Clinically Significant Upper and/or Lower Gastrointestinal Events (CSULGIEs)
Time Frame: Baseline through week 24 or Early Termination (ET)
CSULGIE defined as any of the following: gastroduodenal (GD) hemorrhage; gastric outlet obstruction; GD, small or large bowel perforation; small or large bowel hemorrhage; acute gastrointestinal (GI) hemorrhage of unknown origin; small bowel obstruction; clinically significant anemia/blood loss of defined GI origin or presumed occult GI origin.
Baseline through week 24 or Early Termination (ET)

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Percentage of Participants With Moderate to Severe Abdominal Symptoms
Time Frame: Baseline through week 24 or ET
Abdominal symptoms coded using the Medical Dictionary for Regulatory Activities (MedDRA) System Organ Class (SOC) 'Gastrointestinal Disorders' high level group term (HLGT) equal to "Gastrointestinal Signs and Symptoms"; where moderate indicated the gastrointestinal adverse event (GI AE) interfered to some extent with the participants' usual function and severe indicated the GI AE interfered significantly with participants' usual function.
Baseline through week 24 or ET
Percentage of Participants Who Withdrew Due to GI Adverse Events (AEs)
Time Frame: Baseline through week 24 or ET
GI AEs defined using MedDRA SOC 'Gastrointestinal Disorders' but excluding HLGT's: Benign Neoplasms Gastrointestinal, Dental and Gingival Conditions, Oral Soft Tissue Conditions, Salivary Gland Conditions and Tongue Conditions
Baseline through week 24 or ET
Hemoglobin (Hb) at Baseline
Time Frame: Baseline
Baseline
Change From Baseline Hb at Week 24
Time Frame: Baseline and Week 24 or ET
Baseline and Week 24 or ET
Hematocrit (Hct) at Baseline
Time Frame: Baseline
Baseline
Change From Baseline Hct at Week 24
Time Frame: Baseline and Week 24 or ET
Baseline and Week 24 or ET
Percentage of Participants With Clinically Significant Decrease in Hct and/or Hb From Baseline
Time Frame: Baseline, Weeks 8, 16, 24 or ET
Clinically significant decrease in Hct (greater than or equal to 10 percent [≥10%]) and/or decrease in Hb (≥ 2 g/dL).
Baseline, Weeks 8, 16, 24 or ET
Percentage of Participants Satisfied With Efficacy of Current Pain Medication Overall
Time Frame: Baseline, Weeks 8, 16, 24 or ET
Percentage of participants who reported Very Satisfied or Satisfied with current pain medication question on the Patient Treatment Satisfaction Scale (PTSS), scale ranged from Very Satisfied (1) to Very Dissatisfied (5).
Baseline, Weeks 8, 16, 24 or ET
Percentage of Participants Satisfied With Efficacy of Current Pain Medication - Time to Pain Relief
Time Frame: Baseline, Weeks 8, 16, 24 or ET
Percentage of participants who reported Very Satisfied or Satisfied with efficacy of current pain medication questions on the PTSS Efficacy subscale for the time it took medication to work, scale ranged from Very Satisfied (1) to Very Dissatisfied (5). Possible range of scores 1 to 15.
Baseline, Weeks 8, 16, 24 or ET
Percentage of Participants Satisfied With Efficacy of Current Pain Medication - Amount of Pain Relief
Time Frame: Baseline, Weeks 8, 16, 24 or ET
Percentage of participants who reported Very Satisfied or Satisfied with efficacy of current pain medication questions on the PTSS Efficacy subscale for the amount of pain relief medication provided, scale ranged from Very Satisfied (1) to Very Dissatisfied (5). Possible range of scores 1 to 15.
Baseline, Weeks 8, 16, 24 or ET
Percentage of Participants Satisfied With Efficacy of Current Pain Medication - Duration of Pain Relief
Time Frame: Baseline, Weeks 8, 16, 24 or ET
Percentage of participants who reported Very Satisfied or Satisfied with efficacy of current pain medication questions on the PTSS Efficacy, subscale for duration of pain relief provided by medication, scale ranged from Very Satisfied (1) to Very Dissatisfied (5). Possible range of scores 1 to 15.
Baseline, Weeks 8, 16, 24 or ET

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
Percentage of Participants With Positive Blood Fecal Occult
Time Frame: Week 24 or ET
Positive blood fecal occult; blood in feces that is not visibly apparent
Week 24 or ET
Percentage of Participants With Proton Pump Inhibitor (PPI) and Other Gastric Protective Drug Utilization
Time Frame: Baseline through week 24 or ET
PPI and other gastric protective drug (defined as Histamine-2 receptor antagonists [H2RA], misoprostol, sucralfate, and others such as antacids) utilization.
Baseline through week 24 or ET
Percentage of Participants With Non-study Medication Utilization
Time Frame: Baseline through week 24 or ET
Non-study medication utilization associated with initial treatment defined as narcotic analgesics and acetaminophen use.
Baseline through week 24 or ET

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

October 1, 2006

Primary Completion (Actual)

November 1, 2010

Study Completion (Actual)

November 1, 2010

Study Registration Dates

First Submitted

September 7, 2006

First Submitted That Met QC Criteria

September 7, 2006

First Posted (Estimate)

September 8, 2006

Study Record Updates

Last Update Posted (Actual)

March 3, 2021

Last Update Submitted That Met QC Criteria

March 1, 2021

Last Verified

March 1, 2021

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • A3191331

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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