The Effect of Nocturnal Haemodialysis on Arterial Stiffness

Arterial stiffness refers to the accumulation of extracellular deposits of matrix and calcium which reduce blood vessel compliance. Although there is growing evidence that increased arterial stiffness is associated with chronic kidney disease (CKD), its pathogenesis is unclear. Pulse wave velocity (PWV) and augmentation index (AIx) provide tools for estimating arterial stiffness, and therefore predicting cardiovascular morbidity and mortality. The aims of the study are: (1) compare the effects of nocturnal and conventional haemodialysis on arterial stiffness, and (2) examine the relationship between arterial stiffness and clinical and biochemical parameters.

Study Overview

• Status: Completed
• Conditions: End Stage Renal Disease; Arterial Stiffness
• Intervention / Treatment: Procedure: Nocturnal Hemodialysis

• Study Type: Observational
• Enrollment (Actual): 30

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 80 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

All participants are adult patients who are receiving maintenance dialysis at the North West Dialysis Service. Consecutive patients enrolled in the Nocturnal Haemodialysis program are invited to participate in the study

Description

Inclusion Criteria:

• adult dialysis patients
• able to perform home nocturnal haemodialysis

Exclusion Criteria:

• age < 18 and > 80 years
• any patient who is anticipating a live renal transplantation in forthcoming 12 months

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
To purpose of this study is to evaluate the arterial stiffness in subjects who have undergone 12 months nocturnal haemodialysis.	12 months

Secondary Outcome Measures

Outcome Measure	Time Frame
To examine the relationship between arterial stiffness and clinical and biochemical parameters	12 months

Collaborators and Investigators

• Sponsor: Melbourne Health
• Investigators: Principal Investigator: Michael Lian, FRACP, MBBS, Department of Nephrology, Melbourne Health

Study record dates

Study Major Dates

• Study Start: December 1, 2005
• Primary Completion (Actual): February 1, 2008
• Study Completion (Actual): February 1, 2008

Study Registration Dates

• First Submitted: March 17, 2008
• First Submitted That Met QC Criteria: March 21, 2008
• First Posted (Estimate): March 24, 2008

Study Record Updates

• Last Update Posted (Estimate): April 27, 2015
• Last Update Submitted That Met QC Criteria: April 23, 2015
• Last Verified: April 1, 2015

More Information

Terms related to this study

• Keywords: hemodialysis; cardiovascular; arterial stiffness; end stage renal disease; artery; augmentation index; pulse wave analysis; aortic pulse wave velocity; nocturnal hemodialysis; extended hours of hemodialysis
• Additional Relevant MeSH Terms: Urologic Diseases; Renal Insufficiency; Renal Insufficiency, Chronic; Kidney Diseases; Kidney Failure, Chronic
• Other Study ID Numbers: 2004.050