Effect of Cognitive Behavioral Therapy in OCD Highlighted by Neuropsychological Tests and MRI: Pathophysiology and Treatment Outcome Predictors

August 1, 2012 updated by: University of Aarhus

OCD patients are assessed before and after treatment using diagnostic tools, rating scales neuropsychological assessment and functional and structural MR-scans.

Study Overview

Status

Completed

Conditions

Obsessive-Compulsive Disorder

Study Type

Observational

Enrollment (Actual)

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Denmark
- - Risskov, Denmark, 8240
    - Aarhus University Hospital, Risskov

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 65 years (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

OCD patients from the primary care clinics in middle Jutland, Denmark

Description

Inclusion Criteria:

1. Steady state medication 3 months prior to the study

Exclusion Criteria:

History of head trauma or other organic brain disease
Pregnancy.
Pacemaker or other ferromagnetic materials in the body.
Comorbid psychiatric illnesses assessed using SCAN- interview (30) other than moderate depression (Ham-D<17) or anxiety disorders.
Antipsychotics

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Number of groups / cohorts

Cohorts and Interventions

Group / Cohort
2 Normal Controls
1 OCD patients

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Y-Bocs Time Frame: Before and after treatment approx 20 weeks apart	Before and after treatment approx 20 weeks apart

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Aarhus

Investigators

Principal Investigator: Tue BH Hartmann, Aarhus University Hospital, Risskov
Study Director: Sanne Kjær, Aarhus University Hospital, Risskov

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Vandborg SK, Hartmann TB, Bennedsen BE, Pedersen AD, Thomsen PH. Memory and executive functions in patients with obsessive-compulsive disorder. Cogn Behav Neurol. 2014 Mar;27(1):8-16. doi: 10.1097/WNN.0000000000000021.

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

January 1, 2009

Primary Completion (Actual)

July 1, 2012

Study Completion (Actual)