Paclitaxel and Carboplatin or Ifosfamide in Treating Patients With Newly Diagnosed, Persistent or Recurrent Uterine, Ovarian, Fallopian Tube, or Peritoneal Cavity Cancer
September 28, 2021 updated by: GOG Foundation
A Randomized Phase III Trial of Paclitaxel Plus Carboplatin Versus Ifosfamide Plus Paclitaxel in Chemotherapy-Naive Patients With Newly Diagnosed Stage I-IV, Persistent or Recurrent Carcinosarcoma (Mixed Mesodermal Tumors) of the Uterus, Fallopian Tube, Peritoneum or Ovary
This randomized phase III trial studies paclitaxel and carboplatin see how well they work compared with paclitaxel and ifosfamide in treating patients with fallopian tube, or peritoneal cavity cancer that is newly diagnosed, persistent, or has come back (recurrent).
Drugs used in chemotherapy, such as paclitaxel, carboplatin, and ifosfamide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
It is not yet known whether paclitaxel is more effective when given with carboplatin or ifosfamide in treating patients with uterine, ovarian, fallopian tube, or peritoneal cavity cancer.
Study Overview
Status
Active, not recruiting
Conditions
- Uterine Carcinosarcoma
- Recurrent Fallopian Tube Carcinoma
- Recurrent Ovarian Carcinoma
- Recurrent Primary Peritoneal Carcinoma
- Mixed Mesodermal (Mullerian) Tumor
- Stage I Ovarian Cancer AJCC v6 and v7
- Stage IA Fallopian Tube Cancer AJCC v6 and v7
- Stage IA Ovarian Cancer AJCC v6 and v7
- Stage IB Fallopian Tube Cancer AJCC v6 and v7
- Stage IB Ovarian Cancer AJCC v6 and v7
- Stage IC Fallopian Tube Cancer AJCC v6 and v7
- Stage IC Ovarian Cancer AJCC v6 and v7
- Stage II Ovarian Cancer AJCC v6 and v7
- Stage IIA Fallopian Tube Cancer AJCC v6 and v7
- Stage IIA Ovarian Cancer AJCC V6 and v7
- Stage IIB Fallopian Tube Cancer AJCC v6 and v7
- Stage IIB Ovarian Cancer AJCC v6 and v7
- Stage IIC Fallopian Tube Cancer AJCC v6 and v7
- Stage IIC Ovarian Cancer AJCC v6 and v7
- Stage IIIA Fallopian Tube Cancer AJCC v7
- Stage IIIA Ovarian Cancer AJCC v6 and v7
- Stage IIIA Primary Peritoneal Cancer AJCC v7
- Stage IIIB Fallopian Tube Cancer AJCC v7
- Stage IIIB Ovarian Cancer AJCC v6 and v7
- Stage IIIB Primary Peritoneal Cancer AJCC v7
- Stage IIIC Fallopian Tube Cancer AJCC v7
- Stage IIIC Ovarian Cancer AJCC v6 and v7
- Stage IIIC Primary Peritoneal Cancer AJCC v7
- Stage IV Fallopian Tube Cancer AJCC v6 and v7
- Stage IV Ovarian Cancer AJCC v6 and v7
- Stage IV Primary Peritoneal Cancer AJCC v7
- Ovarian Carcinosarcoma
- Stage IA Uterine Sarcoma AJCC v7
- Stage IB Uterine Sarcoma AJCC v7
- Stage IC Uterine Sarcoma AJCC v7
- Stage IIA Uterine Sarcoma AJCC v7
- Stage IIB Uterine Sarcoma AJCC v7
- Stage IIIA Uterine Sarcoma AJCC v7
- Stage IIIB Uterine Sarcoma AJCC v7
- Stage IIIC Uterine Sarcoma AJCC v7
- Stage IVA Uterine Sarcoma AJCC v7
- Stage IVB Uterine Sarcoma AJCC v7
Intervention / Treatment
Detailed Description
PRIMARY OBJECTIVES:
I. To determine if treatment with combination paclitaxel and carboplatin (TC) chemotherapy does not result in an inferior death rate when compared to ifosfamide, mesna, and paclitaxel chemotherapy.
SECONDARY OBJECTIVES:
I. To determine if treatment with combination paclitaxel and carboplatin (TC) chemotherapy does not result in an inferior progression-free survival when compared to ifosfamide, mesna, and paclitaxel chemotherapy.
II. To determine if acute toxicity, specifically physician-assessed neurotoxicity and infection, associated with combination paclitaxel and carboplatin chemotherapy is reduced compared to that of ifosfamide, mesna, and paclitaxel chemotherapy.
III. To determine if treatment with combination paclitaxel and carboplatin chemotherapy is associated with superior patient-reported quality of life and neurotoxicity scores compared to that of ifosfamide, mesna, and paclitaxel chemotherapy.
TERTIARY OBJECTIVES:
I. To bank formalin-fixed, paraffin-embedded (FFPE) tumor tissue and deoxyribonucleic acid (DNA) extracted from whole blood for future research.
OUTLINE: Patients are randomized to 1 of 2 treatment arms.
ARM I: Patients receive paclitaxel intravenously (IV) over 3 hours followed by carboplatin IV over 30-60 minutes on day 1.
ARM II: Patients receive ifosfamide IV over 1 hour on days 1-3 followed by paclitaxel as in Arm I.
In both arms, treatment repeats every 21 days for 6-10 courses in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 3 months for 2 years, every 6 months for 3 years, and then annually thereafter.
Study Type
Interventional
Enrollment (Actual)
637
Phase
- Phase 3
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Seoul, Korea, Republic of, 110-744
- Seoul National University Hospital
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Seoul, Korea, Republic of, 05505
- Asan Medical Center
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Seoul, Korea, Republic of, 06273
- Gangnam Severance Hospital
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Seoul, Korea, Republic of, 139-706
- Korea Cancer Center Hospital
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Daegu
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Dalseo-gu, Daegu, Korea, Republic of, 42601
- Keimyung University-Dongsan Medical Center
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Gyeonggi-do
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Goyang-si, Gyeonggi-do, Korea, Republic of, 410-769
- National Cancer Center-Korea
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Alabama
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Birmingham, Alabama, United States, 35233
- University of Alabama at Birmingham Cancer Center
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Mobile, Alabama, United States, 36688
- University of South Alabama Mitchell Cancer Institute
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Arizona
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Phoenix, Arizona, United States, 85054
- Mayo Clinic Hospital in Arizona
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Phoenix, Arizona, United States, 85013
- Saint Joseph's Hospital and Medical Center
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Scottsdale, Arizona, United States, 85259
- Mayo Clinic in Arizona
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Tucson, Arizona, United States, 85704
- University of Arizona Cancer Center-Orange Grove Campus
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Tucson, Arizona, United States, 85719
- Banner University Medical Center - Tucson
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Tucson, Arizona, United States, 85719
- University of Arizona Cancer Center-North Campus
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Arkansas
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Jonesboro, Arkansas, United States, 72401
- Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
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California
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Burbank, California, United States, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Concord, California, United States, 94520
- John Muir Medical Center-Concord Campus
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La Jolla, California, United States, 92093
- UC San Diego Moores Cancer Center
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Los Angeles, California, United States, 90033
- USC / Norris Comprehensive Cancer Center
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Los Angeles, California, United States, 90033
- Los Angeles County-USC Medical Center
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Los Angeles, California, United States, 90095
- UCLA / Jonsson Comprehensive Cancer Center
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Los Angeles, California, United States, 90027
- Kaiser Permanente Los Angeles Medical Center
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Los Angeles, California, United States, 90048
- Cedars Sinai Medical Center
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Mountain View, California, United States, 94040
- Palo Alto Medical Foundation-Gynecologic Oncology
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Newport Beach, California, United States, 92663
- Gynecologic Oncology Associates-Newport Beach
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Orange, California, United States, 92868
- UC Irvine Health/Chao Family Comprehensive Cancer Center
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Orange, California, United States, 92868
- Saint Joseph Hospital - Orange
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Palo Alto, California, United States, 94304
- Stanford Cancer Institute Palo Alto
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Roseville, California, United States, 95661
- Sutter Roseville Medical Center
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Sacramento, California, United States, 95816
- Sutter Medical Center Sacramento
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Sacramento, California, United States, 95817
- University of California Davis Comprehensive Cancer Center
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San Francisco, California, United States, 94115
- UCSF Medical Center-Mount Zion
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Sylmar, California, United States, 91342
- Olive View-University of California Los Angeles Medical Center
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Walnut Creek, California, United States, 94598
- John Muir Medical Center-Walnut Creek
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Colorado
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Aurora, Colorado, United States, 80045
- University Of Colorado Hospital
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Aurora, Colorado, United States, 80012
- The Medical Center of Aurora
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Boulder, Colorado, United States, 80301
- Boulder Community Hospital
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Boulder, Colorado, United States, 80304
- Rocky Mountain Cancer Centers-Boulder
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Colorado Springs, Colorado, United States, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, United States, 80907
- Rocky Mountain Cancer Centers-Penrose
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Denver, Colorado, United States, 80210
- Porter Adventist Hospital
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Denver, Colorado, United States, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, United States, 80218
- SCL Health Saint Joseph Hospital
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Denver, Colorado, United States, 80220
- Rose Medical Center
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Denver, Colorado, United States, 80218
- Rocky Mountain Cancer Centers-Midtown
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Denver, Colorado, United States, 80220
- Rocky Mountain Cancer Centers-Rose
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Denver, Colorado, United States, 80218
- Colorado Blood Cancer Institute
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Denver, Colorado, United States, 80222
- Western States Cancer Research NCORP
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Durango, Colorado, United States, 81301
- Mercy Medical Center
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Englewood, Colorado, United States, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, United States, 80113
- Swedish Medical Center
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Golden, Colorado, United States, 80401
- Mountain Blue Cancer Care Center
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Grand Junction, Colorado, United States, 81501
- Saint Mary's Hospital and Regional Medical Center
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Greeley, Colorado, United States, 80631
- North Colorado Medical Center
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Greenwood Village, Colorado, United States, 80111
- Rocky Mountain Cancer Centers-Greenwood Village
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Lakewood, Colorado, United States, 80228
- Saint Anthony Hospital
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Lakewood, Colorado, United States, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Littleton, Colorado, United States, 80122
- Littleton Adventist Hospital
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Lone Tree, Colorado, United States, 80124
- Sky Ridge Medical Center
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Lone Tree, Colorado, United States, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
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Longmont, Colorado, United States, 80501
- Longmont United Hospital
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Longmont, Colorado, United States, 80501
- Rocky Mountain Cancer Centers-Longmont
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Loveland, Colorado, United States, 80539
- McKee Medical Center
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Parker, Colorado, United States, 80138
- Parker Adventist Hospital
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Parker, Colorado, United States, 80138
- Rocky Mountain Cancer Centers-Parker
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Pueblo, Colorado, United States, 81004
- Saint Mary Corwin Medical Center
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Pueblo, Colorado, United States, 81008
- Rocky Mountain Cancer Centers - Pueblo
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Thornton, Colorado, United States, 80229
- North Suburban Medical Center
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Wheat Ridge, Colorado, United States, 80033
- SCL Health Lutheran Medical Center
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Connecticut
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Hartford, Connecticut, United States, 06105
- Smilow Cancer Hospital Care Center at Saint Francis
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Hartford, Connecticut, United States, 06102
- Hartford Hospital
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New Britain, Connecticut, United States, 06050
- The Hospital of Central Connecticut
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New Haven, Connecticut, United States, 06520
- Yale University
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Norwich, Connecticut, United States, 06360
- Eastern Connecticut Hematology and Oncology Associates
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Stamford, Connecticut, United States, 06904
- Stamford Hospital/Bennett Cancer Center
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Delaware
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Lewes, Delaware, United States, 19958
- Beebe Medical Center
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Newark, Delaware, United States, 19718
- Christiana Care Health System-Christiana Hospital
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District of Columbia
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Washington, District of Columbia, United States, 20010
- MedStar Washington Hospital Center
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Florida
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Fort Myers, Florida, United States, 33905
- Florida Gynecologic Oncology
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Jacksonville, Florida, United States, 32224-9980
- Mayo Clinic in Florida
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Lakeland, Florida, United States, 33805
- Lakeland Regional Health Hollis Cancer Center
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Miami, Florida, United States, 33133
- Mercy Hospital
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Orlando, Florida, United States, 32806
- Orlando Health Cancer Institute
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Orlando, Florida, United States, 32803
- AdventHealth Orlando
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Georgia
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Atlanta, Georgia, United States, 30309
- Piedmont Hospital
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Atlanta, Georgia, United States, 30342
- Northside Hospital
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Augusta, Georgia, United States, 30912
- Augusta University Medical Center
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Columbus, Georgia, United States, 31904
- John B Amos Cancer Center
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Macon, Georgia, United States, 31201
- Central Georgia Gynecologic Oncology
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Savannah, Georgia, United States, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Savannah, Georgia, United States, 31404
- Memorial Health University Medical Center
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Idaho
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Boise, Idaho, United States, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Lewiston, Idaho, United States, 83501
- Saint Joseph Regional Medical Center
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Illinois
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Aurora, Illinois, United States, 60504
- Rush - Copley Medical Center
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Bloomington, Illinois, United States, 61704
- Illinois CancerCare-Bloomington
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Bloomington, Illinois, United States, 61701
- Saint Joseph Medical Center
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Canton, Illinois, United States, 61520
- Illinois CancerCare-Canton
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Canton, Illinois, United States, 61520
- Graham Hospital Association
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Carthage, Illinois, United States, 62321
- Illinois CancerCare-Carthage
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Carthage, Illinois, United States, 62321
- Memorial Hospital
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Chicago, Illinois, United States, 60611
- Northwestern University
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Chicago, Illinois, United States, 60612
- Rush University Medical Center
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Chicago, Illinois, United States, 60637
- University of Chicago Comprehensive Cancer Center
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Chicago, Illinois, United States, 60612
- John H Stroger Jr Hospital of Cook County
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Decatur, Illinois, United States, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, United States, 62526
- Heartland Cancer Research NCORP
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Eureka, Illinois, United States, 61530
- Illinois CancerCare-Eureka
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Eureka, Illinois, United States, 61530
- Eureka Hospital
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Galesburg, Illinois, United States, 61401
- Western Illinois Cancer Treatment Center
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Galesburg, Illinois, United States, 61401
- Illinois CancerCare-Galesburg
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Havana, Illinois, United States, 62644
- Mason District Hospital
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Havana, Illinois, United States, 62644
- Illinois CancerCare-Havana
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Hinsdale, Illinois, United States, 60521
- Sudarshan K Sharma MD Limited-Gynecologic Oncology
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Kewanee, Illinois, United States, 61443
- Illinois CancerCare-Kewanee Clinic
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Macomb, Illinois, United States, 61455
- Illinois CancerCare-Macomb
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Macomb, Illinois, United States, 61455
- Mcdonough District Hospital
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Maywood, Illinois, United States, 60153
- Loyola University Medical Center
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Monmouth, Illinois, United States, 61462
- Illinois CancerCare-Monmouth
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Monmouth, Illinois, United States, 61462
- Holy Family Medical Center
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Mount Vernon, Illinois, United States, 62864
- Good Samaritan Regional Health Center
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Normal, Illinois, United States, 61761
- Carle Cancer Institute Normal
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Normal, Illinois, United States, 61761
- Bromenn Regional Medical Center
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Normal, Illinois, United States, 61761
- Illinois CancerCare-Community Cancer Center
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Oak Lawn, Illinois, United States, 60453-2699
- Advocate Christ Medical Center
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Ottawa, Illinois, United States, 61350
- Illinois CancerCare-Ottawa Clinic
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Ottawa, Illinois, United States, 61350
- Radiation Oncology of Northern Illinois
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Ottawa, Illinois, United States, 61350
- Ottawa Regional Hospital and Healthcare Center
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Pekin, Illinois, United States, 61554
- Illinois CancerCare-Pekin
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Pekin, Illinois, United States, 61554
- OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
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Peoria, Illinois, United States, 61636
- Methodist Medical Center of Illinois
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Peoria, Illinois, United States, 61637
- OSF Saint Francis Medical Center
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Peoria, Illinois, United States, 61615
- Illinois CancerCare-Peoria
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Peoria, Illinois, United States, 61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
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Peoria, Illinois, United States, 61614
- Proctor Hospital
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Peru, Illinois, United States, 61354
- Illinois CancerCare-Peru
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Peru, Illinois, United States, 61354
- Valley Radiation Oncology
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Peru, Illinois, United States, 61354
- Illinois Valley Hospital
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Princeton, Illinois, United States, 61356
- Illinois CancerCare-Princeton
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Princeton, Illinois, United States, 61356
- Perry Memorial Hospital
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Spring Valley, Illinois, United States, 61362
- Illinois CancerCare-Spring Valley
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Springfield, Illinois, United States, 62781
- Memorial Medical Center
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Urbana, Illinois, United States, 61801
- Carle Cancer Center
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Warrenville, Illinois, United States, 60555
- Northwestern Medicine Cancer Center Warrenville
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Indiana
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Beech Grove, Indiana, United States, 46107
- Franciscan Saint Francis Health-Beech Grove
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Elkhart, Indiana, United States, 46515
- Elkhart General Hospital
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Elkhart, Indiana, United States, 46514
- Michiana Hematology Oncology PC-Elkhart
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Elkhart, Indiana, United States, 46514-2098
- Elkhart Clinic
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Indianapolis, Indiana, United States, 46237
- Franciscan Health Indianapolis
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Indianapolis, Indiana, United States, 46202
- Indiana University/Melvin and Bren Simon Cancer Center
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Indianapolis, Indiana, United States, 46260
- Saint Vincent Hospital and Health Care Center
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Kokomo, Indiana, United States, 46904
- Community Howard Regional Health
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La Porte, Indiana, United States, 46350
- IU Health La Porte Hospital
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Michigan City, Indiana, United States, 46360
- Franciscan Saint Anthony Health-Michigan City
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Mishawaka, Indiana, United States, 46545
- Michiana Hematology Oncology PC-Mishawaka
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Mishawaka, Indiana, United States, 46545
- Cancer Care Partners LLC
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Mishawaka, Indiana, United States, 46545
- Saint Joseph Regional Medical Center-Mishawaka
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Munster, Indiana, United States, 46321
- The Community Hospital
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Plymouth, Indiana, United States, 46563
- Michiana Hematology Oncology PC-Plymouth
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Richmond, Indiana, United States, 47374
- Reid Health
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South Bend, Indiana, United States, 46601
- Memorial Hospital of South Bend
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South Bend, Indiana, United States, 46601
- Michiana Hematology Oncology PC-South Bend
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South Bend, Indiana, United States, 46628
- Northern Indiana Cancer Research Consortium
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South Bend, Indiana, United States, 46617
- South Bend Clinic
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Westville, Indiana, United States, 46391
- Michiana Hematology Oncology PC-Westville
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Iowa
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Ames, Iowa, United States, 50010
- McFarland Clinic PC - Ames
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Clive, Iowa, United States, 50325
- Mercy Cancer Center-West Lakes
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Clive, Iowa, United States, 50325
- Medical Oncology and Hematology Associates-West Des Moines
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Des Moines, Iowa, United States, 50309
- Iowa Methodist Medical Center
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Des Moines, Iowa, United States, 50314
- Mercy Medical Center - Des Moines
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Des Moines, Iowa, United States, 50309
- Medical Oncology and Hematology Associates-Des Moines
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Des Moines, Iowa, United States, 50316
- Iowa Lutheran Hospital
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Des Moines, Iowa, United States, 50309
- Iowa-Wide Oncology Research Coalition NCORP
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Des Moines, Iowa, United States, 50314
- Medical Oncology and Hematology Associates-Laurel
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Iowa City, Iowa, United States, 52242
- University of Iowa/Holden Comprehensive Cancer Center
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Sioux City, Iowa, United States, 51101
- Siouxland Regional Cancer Center
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Sioux City, Iowa, United States, 51102
- Mercy Medical Center-Sioux City
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Sioux City, Iowa, United States, 51104
- Saint Luke's Regional Medical Center
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West Des Moines, Iowa, United States, 50266-7700
- Methodist West Hospital
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West Des Moines, Iowa, United States, 50266
- Mercy Medical Center-West Lakes
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Kansas
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Chanute, Kansas, United States, 66720
- Cancer Center of Kansas - Chanute
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Dodge City, Kansas, United States, 67801
- Cancer Center of Kansas - Dodge City
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El Dorado, Kansas, United States, 67042
- Cancer Center of Kansas - El Dorado
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Fort Scott, Kansas, United States, 66701
- Cancer Center of Kansas - Fort Scott
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Independence, Kansas, United States, 67301
- Cancer Center of Kansas-Independence
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Kansas City, Kansas, United States, 66160
- University of Kansas Cancer Center
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Kansas City, Kansas, United States, 66112
- Providence Medical Center
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Kingman, Kansas, United States, 67068
- Cancer Center of Kansas-Kingman
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Lawrence, Kansas, United States, 66044
- Lawrence Memorial Hospital
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Liberal, Kansas, United States, 67905
- Cancer Center of Kansas-Liberal
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Manhattan, Kansas, United States, 66502
- Cancer Center of Kansas-Manhattan
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McPherson, Kansas, United States, 67460
- Cancer Center of Kansas - McPherson
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Newton, Kansas, United States, 67114
- Cancer Center of Kansas - Newton
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Overland Park, Kansas, United States, 66209
- Menorah Medical Center
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Overland Park, Kansas, United States, 66213
- Saint Luke's South Hospital
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Parsons, Kansas, United States, 67357
- Cancer Center of Kansas - Parsons
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Prairie Village, Kansas, United States, 66208
- Kansas City NCI Community Oncology Research Program
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Pratt, Kansas, United States, 67124
- Cancer Center of Kansas - Pratt
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Salina, Kansas, United States, 67401
- Cancer Center of Kansas - Salina
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Shawnee Mission, Kansas, United States, 66204
- Advent Health - Shawnee Mission Medical Center
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Wellington, Kansas, United States, 67152
- Cancer Center of Kansas - Wellington
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Wichita, Kansas, United States, 67214
- Ascension Via Christi Hospitals Wichita
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Wichita, Kansas, United States, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
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Wichita, Kansas, United States, 67214
- Cancer Center of Kansas - Wichita
-
Wichita, Kansas, United States, 67208
- Associates In Womens Health
-
Wichita, Kansas, United States, 67214
- Wichita NCI Community Oncology Research Program
-
Wichita, Kansas, United States, 67214
- Wesley Medical Center
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Winfield, Kansas, United States, 67156
- Cancer Center of Kansas - Winfield
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Kentucky
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Crestview Hills, Kentucky, United States, 41017
- Oncology Hematology Care Inc-Crestview
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Lexington, Kentucky, United States, 40536
- University of Kentucky/Markey Cancer Center
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Louisville, Kentucky, United States, 40202
- Norton Hospital Pavilion and Medical Campus
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Louisiana
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Baton Rouge, Louisiana, United States, 70817
- Woman's Hospital
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New Orleans, Louisiana, United States, 70121
- Ochsner Medical Center Jefferson
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Shreveport, Louisiana, United States, 71103
- LSU Health Sciences Center at Shreveport
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Maryland
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Baltimore, Maryland, United States, 21237
- MedStar Franklin Square Medical Center/Weinberg Cancer Institute
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Baltimore, Maryland, United States, 21215
- Sinai Hospital of Baltimore
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Baltimore, Maryland, United States, 21204
- Greater Baltimore Medical Center
-
Baltimore, Maryland, United States, 21201
- University of Maryland/Greenebaum Cancer Center
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Bethesda, Maryland, United States, 20889-5600
- Walter Reed National Military Medical Center
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Elkton, Maryland, United States, 21921
- Christiana Care - Union Hospital
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Massachusetts
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Springfield, Massachusetts, United States, 01199
- Baystate Medical Center
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Worcester, Massachusetts, United States, 01605
- UMass Memorial Medical Center - Memorial Division
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Michigan
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Adrian, Michigan, United States, 49221
- Bixby Medical Center
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Adrian, Michigan, United States, 49221
- Hickman Cancer Center
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Ann Arbor, Michigan, United States, 48109
- University Of Michigan Comprehensive Cancer Center
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Ann Arbor, Michigan, United States, 48106
- Saint Joseph Mercy Hospital
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Ann Arbor, Michigan, United States, 48106
- Michigan Cancer Research Consortium NCORP
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Battle Creek, Michigan, United States, 49017
- Bronson Battle Creek
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Big Rapids, Michigan, United States, 49307
- Spectrum Health Big Rapids Hospital
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Dearborn, Michigan, United States, 48124
- Beaumont Hospital - Dearborn
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Detroit, Michigan, United States, 48202
- Henry Ford Hospital
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Detroit, Michigan, United States, 48201
- Wayne State University/Karmanos Cancer Institute
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Detroit, Michigan, United States, 48236
- Ascension Saint John Hospital
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Farmington Hills, Michigan, United States, 48334
- Weisberg Cancer Treatment Center
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Flint, Michigan, United States, 48532
- Genesys Regional Medical Center-West Flint Campus
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Flint, Michigan, United States, 48503
- Hurley Medical Center
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Flint, Michigan, United States, 48503
- Genesys Hurley Cancer Institute
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Grand Blanc, Michigan, United States, 48439
- Genesys Regional Medical Center
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Grand Rapids, Michigan, United States, 49503
- Spectrum Health at Butterworth Campus
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Grand Rapids, Michigan, United States, 49503
- Mercy Health Saint Mary's
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Grand Rapids, Michigan, United States, 49503
- Cancer Research Consortium of West Michigan NCORP
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Jackson, Michigan, United States, 49201
- Allegiance Health
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Kalamazoo, Michigan, United States, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, United States, 49007
- Bronson Methodist Hospital
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Kalamazoo, Michigan, United States, 49048
- Borgess Medical Center
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Lansing, Michigan, United States, 48912
- Sparrow Hospital
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Livonia, Michigan, United States, 48154
- Saint Mary Mercy Hospital
-
Monroe, Michigan, United States, 48162
- Mercy Memorial Hospital
-
Monroe, Michigan, United States, 48162
- Toledo Clinic Cancer Centers-Monroe
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Muskegon, Michigan, United States, 49444
- Mercy Health Mercy Campus
-
Niles, Michigan, United States, 49120
- Lakeland Hospital Niles
-
Pontiac, Michigan, United States, 48341
- Saint Joseph Mercy Oakland
-
Port Huron, Michigan, United States, 48060
- Lake Huron Medical Center
-
Reed City, Michigan, United States, 49677
- Spectrum Health Reed City Hospital
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Royal Oak, Michigan, United States, 48073
- William Beaumont Hospital-Royal Oak
-
Saginaw, Michigan, United States, 48601
- Ascension Saint Mary's Hospital
-
Saint Joseph, Michigan, United States, 49085
- Lakeland Medical Center Saint Joseph
-
Saint Joseph, Michigan, United States, 49085
- Marie Yeager Cancer Center
-
Southfield, Michigan, United States, 48075
- Ascension Providence Hospitals - Southfield
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Traverse City, Michigan, United States, 49684
- Munson Medical Center
-
Troy, Michigan, United States, 48085
- William Beaumont Hospital - Troy
-
Warren, Michigan, United States, 48093
- Saint John Macomb-Oakland Hospital
-
Wyoming, Michigan, United States, 49519
- Metro Health Hospital
-
-
Minnesota
-
Bemidji, Minnesota, United States, 56601
- Sanford Joe Lueken Cancer Center
-
Burnsville, Minnesota, United States, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, United States, 55433
- Mercy Hospital
-
Edina, Minnesota, United States, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, United States, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fridley, Minnesota, United States, 55432
- Unity Hospital
-
Hutchinson, Minnesota, United States, 55350
- Hutchinson Area Health Care
-
Maplewood, Minnesota, United States, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, United States, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, United States, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, United States, 55407
- Abbott-Northwestern Hospital
-
New Ulm, Minnesota, United States, 56073
- New Ulm Medical Center
-
Robbinsdale, Minnesota, United States, 55422
- North Memorial Medical Health Center
-
Rochester, Minnesota, United States, 55905
- Mayo Clinic in Rochester
-
Saint Louis Park, Minnesota, United States, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Louis Park, Minnesota, United States, 55416
- Metro Minnesota Community Oncology Research Consortium
-
Saint Paul, Minnesota, United States, 55101
- Regions Hospital
-
Saint Paul, Minnesota, United States, 55102
- United Hospital
-
Shakopee, Minnesota, United States, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, United States, 55082
- Lakeview Hospital
-
Waconia, Minnesota, United States, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, United States, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, United States, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
-
Mississippi
-
Jackson, Mississippi, United States, 39216
- University of Mississippi Medical Center
-
-
Missouri
-
Bolivar, Missouri, United States, 65613
- Central Care Cancer Center - Bolivar
-
Branson, Missouri, United States, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, United States, 63703
- Saint Francis Medical Center
-
Columbia, Missouri, United States, 65212
- University of Missouri - Ellis Fischel
-
Independence, Missouri, United States, 64057
- Centerpoint Medical Center LLC
-
Joplin, Missouri, United States, 64804
- Freeman Health System
-
Joplin, Missouri, United States, 64804
- Mercy Hospital Joplin
-
Kansas City, Missouri, United States, 64116
- North Kansas City Hospital
-
Kansas City, Missouri, United States, 64111
- Saint Luke's Hospital of Kansas City
-
Kansas City, Missouri, United States, 64132
- Research Medical Center
-
Kansas City, Missouri, United States, 64108
- Truman Medical Centers
-
Kansas City, Missouri, United States, 64118
- Heartland Hematology and Oncology Associates Incorporated
-
Kansas City, Missouri, United States, 64114
- Saint Joseph Health Center
-
Lee's Summit, Missouri, United States, 64086
- Saint Luke's East - Lee's Summit
-
Liberty, Missouri, United States, 64068
- Liberty Radiation Oncology Center
-
Rolla, Missouri, United States, 65401
- Delbert Day Cancer Institute at PCRMC
-
Rolla, Missouri, United States, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Saint Joseph, Missouri, United States, 64506
- Heartland Regional Medical Center
-
Saint Joseph, Missouri, United States, 64507
- Saint Joseph Oncology Inc
-
Saint Louis, Missouri, United States, 63110
- Washington University School of Medicine
-
Saint Louis, Missouri, United States, 63141
- Mercy Hospital Saint Louis
-
Saint Louis, Missouri, United States, 63109
- Saint Louis Cancer and Breast Institute-South City
-
Saint Louis, Missouri, United States, 63104
- SSM Health Saint Louis University Hospital
-
Springfield, Missouri, United States, 65804
- Cancer Research for the Ozarks NCORP
-
Springfield, Missouri, United States, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, United States, 65804
- Mercy Hospital Springfield
-
-
Montana
-
Billings, Montana, United States, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, United States, 59101
- Saint Vincent Healthcare
-
Billings, Montana, United States, 59102
- Montana Cancer Consortium NCORP
-
Billings, Montana, United States, 59102
- Saint Vincent Frontier Cancer Center
-
Bozeman, Montana, United States, 59715
- Bozeman Deaconess Hospital
-
Butte, Montana, United States, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, United States, 59405
- Great Falls Clinic
-
Great Falls, Montana, United States, 59405
- Benefis Healthcare- Sletten Cancer Institute
-
Havre, Montana, United States, 59501
- Northern Montana Hospital
-
Helena, Montana, United States, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, United States, 59901
- Kalispell Regional Medical Center
-
Kalispell, Montana, United States, 59901
- Glacier Oncology PLLC
-
Kalispell, Montana, United States, 59901
- Kalispell Medical Oncology
-
Missoula, Montana, United States, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, United States, 59802
- Montana Cancer Specialists
-
-
Nebraska
-
Omaha, Nebraska, United States, 68114
- Nebraska Methodist Hospital
-
Omaha, Nebraska, United States, 68198
- University of Nebraska Medical Center
-
-
Nevada
-
Las Vegas, Nevada, United States, 89169
- Women's Cancer Center of Nevada
-
Reno, Nevada, United States, 89502
- Renown Regional Medical Center
-
Reno, Nevada, United States, 89502
- Center of Hope at Renown Medical Center
-
-
New Hampshire
-
Lebanon, New Hampshire, United States, 03756
- Dartmouth Hitchcock Medical Center
-
-
New Jersey
-
Camden, New Jersey, United States, 08103
- Cooper Hospital University Medical Center
-
Hackensack, New Jersey, United States, 07601
- Hackensack University Medical Center
-
Mount Holly, New Jersey, United States, 08060
- Virtua Memorial
-
Neptune, New Jersey, United States, 07753
- Jersey Shore Medical Center
-
New Brunswick, New Jersey, United States, 08903
- Rutgers Cancer Institute of New Jersey
-
Newark, New Jersey, United States, 07101
- Rutgers New Jersey Medical School
-
Voorhees, New Jersey, United States, 08043
- Virtua Voorhees
-
-
New Mexico
-
Albuquerque, New Mexico, United States, 87102
- University of New Mexico Cancer Center
-
Albuquerque, New Mexico, United States, 87106
- Southwest Gynecologic Oncology Associates Inc
-
-
New York
-
Albany, New York, United States, 12208
- Women's Cancer Care Associates LLC
-
Brightwaters, New York, United States, 11718
- Island Gynecologic Oncology
-
Brooklyn, New York, United States, 11203
- State University of New York Downstate Medical Center
-
Buffalo, New York, United States, 14263
- Roswell Park Cancer Institute
-
Fresh Meadows, New York, United States, 11365
- New York Hospital Medical Center of Queens
-
Lake Success, New York, United States, 11042
- Northwell Health/Center for Advanced Medicine
-
Manhasset, New York, United States, 11030
- North Shore University Hospital
-
New Hyde Park, New York, United States, 11040
- Long Island Jewish Medical Center
-
New York, New York, United States, 10065
- Memorial Sloan Kettering Cancer Center
-
New York, New York, United States, 10029
- Mount Sinai Hospital
-
New York, New York, United States, 10065
- NYP/Weill Cornell Medical Center
-
Staten Island, New York, United States, 10305
- Staten Island University Hospital
-
Stony Brook, New York, United States, 11794
- Stony Brook University Medical Center
-
Syracuse, New York, United States, 13210
- State University of New York Upstate Medical University
-
Valhalla, New York, United States, 10595
- New York Medical College
-
Valhalla, New York, United States, 10595
- Westchester Medical Center
-
-
North Carolina
-
Burlington, North Carolina, United States, 27215
- Cone Health Cancer Center at Alamance Regional
-
Chapel Hill, North Carolina, United States, 27599
- UNC Lineberger Comprehensive Cancer Center
-
Charlotte, North Carolina, United States, 28203
- Carolinas Medical Center/Levine Cancer Institute
-
Charlotte, North Carolina, United States, 28204
- Novant Health Presbyterian Medical Center
-
Concord, North Carolina, United States, 28025
- Atrium Health Cabarrus/LCI-Concord
-
Durham, North Carolina, United States, 27710
- Duke University Medical Center
-
Hendersonville, North Carolina, United States, 28792
- AdventHealth Hendersonville
-
Kinston, North Carolina, United States, 28501
- Vidant Oncology-Kinston
-
Rutherfordton, North Carolina, United States, 28139
- Rutherford Hospital
-
Winston-Salem, North Carolina, United States, 27157
- Wake Forest University Health Sciences
-
Winston-Salem, North Carolina, United States, 27104
- Southeast Clinical Oncology Research Consortium NCORP
-
-
North Dakota
-
Fargo, North Dakota, United States, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, United States, 58122
- Sanford Broadway Medical Center
-
Fargo, North Dakota, United States, 58122
- Sanford Clinic North-Fargo
-
-
Ohio
-
Akron, Ohio, United States, 44307
- Cleveland Clinic Akron General
-
Akron, Ohio, United States, 44304
- Summa Health System - Akron Campus
-
Belpre, Ohio, United States, 45714
- Strecker Cancer Center-Belpre
-
Bowling Green, Ohio, United States, 43402
- Toledo Clinic Cancer Centers-Bowling Green
-
Canton, Ohio, United States, 44710
- Aultman Health Foundation
-
Chillicothe, Ohio, United States, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, United States, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati, Ohio, United States, 45242
- Oncology Hematology Care Inc-Blue Ash
-
Cincinnati, Ohio, United States, 45202
- Oncology Hematology Care Inc-Eden Park
-
Cincinnati, Ohio, United States, 45211
- Oncology Hematology Care Inc-Mercy West
-
Cincinnati, Ohio, United States, 45230
- Oncology Hematology Care Inc-Anderson
-
Cincinnati, Ohio, United States, 45236
- Oncology Hematology Care Inc-Kenwood
-
Cleveland, Ohio, United States, 44106
- Case Western Reserve University
-
Cleveland, Ohio, United States, 44109
- MetroHealth Medical Center
-
Cleveland, Ohio, United States, 44195
- Cleveland Clinic Foundation
-
Cleveland, Ohio, United States, 44111
- Cleveland Clinic Cancer Center/Fairview Hospital
-
Columbus, Ohio, United States, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, United States, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, United States, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, United States, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, United States, 43228
- Doctors Hospital
-
Columbus, Ohio, United States, 43215
- Grant Medical Center
-
Columbus, Ohio, United States, 43222
- Mount Carmel Health Center West
-
Columbus, Ohio, United States, 43215
- Columbus NCI Community Oncology Research Program
-
Dayton, Ohio, United States, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, United States, 45409
- Miami Valley Hospital
-
Dayton, Ohio, United States, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, United States, 45405
- Grandview Hospital
-
Dayton, Ohio, United States, 45459
- Dayton NCI Community Oncology Research Program
-
Delaware, Ohio, United States, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, United States, 43015
- Grady Memorial Hospital
-
Fairfield, Ohio, United States, 45014
- Oncology Hematology Care Inc-Healthplex
-
Findlay, Ohio, United States, 45840
- Blanchard Valley Hospital
-
Franklin, Ohio, United States, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Greenville, Ohio, United States, 45331
- Wayne Hospital
-
Kettering, Ohio, United States, 45429
- Kettering Medical Center
-
Lancaster, Ohio, United States, 43130
- Fairfield Medical Center
-
Lima, Ohio, United States, 45801
- Saint Rita's Medical Center
-
Lima, Ohio, United States, 45804
- Lima Memorial Hospital
-
Marietta, Ohio, United States, 45750
- Marietta Memorial Hospital
-
Maumee, Ohio, United States, 43537
- Toledo Clinic Cancer Centers-Maumee
-
Maumee, Ohio, United States, 43537
- Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
-
Mayfield Heights, Ohio, United States, 44124
- Hillcrest Hospital Cancer Center
-
Mentor, Ohio, United States, 44060
- UH Seidman Cancer Center at Lake Health Mentor Campus
-
Mount Vernon, Ohio, United States, 43050
- Knox Community Hospital
-
Newark, Ohio, United States, 43055
- Licking Memorial Hospital
-
Oregon, Ohio, United States, 43616
- Saint Charles Hospital
-
Oregon, Ohio, United States, 43616
- Toledo Clinic Cancer Centers-Oregon
-
Portsmouth, Ohio, United States, 45662
- Southern Ohio Medical Center
-
Springfield, Ohio, United States, 45505
- Springfield Regional Medical Center
-
Sylvania, Ohio, United States, 43560
- ProMedica Flower Hospital
-
Tiffin, Ohio, United States, 44883
- Mercy Hospital of Tiffin
-
Toledo, Ohio, United States, 43606
- ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
-
Toledo, Ohio, United States, 43608
- Saint Vincent Mercy Medical Center
-
Toledo, Ohio, United States, 43623
- Mercy Health - Saint Anne Hospital
-
Toledo, Ohio, United States, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Toledo, Ohio, United States, 43614
- University of Toledo
-
Toledo, Ohio, United States, 43617
- Toledo Community Hospital Oncology Program CCOP
-
Troy, Ohio, United States, 45373
- Upper Valley Medical Center
-
Wauseon, Ohio, United States, 43567
- Fulton County Health Center
-
Westerville, Ohio, United States, 43081
- Saint Ann's Hospital
-
Wilmington, Ohio, United States, 45177
- Clinton Memorial Hospital
-
Xenia, Ohio, United States, 45385
- Greene Memorial Hospital
-
Zanesville, Ohio, United States, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Oklahoma City, Oklahoma, United States, 73104
- University of Oklahoma Health Sciences Center
-
Tulsa, Oklahoma, United States, 74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
-
Pennsylvania
-
Abington, Pennsylvania, United States, 19001
- Jefferson Abington Hospital
-
Allentown, Pennsylvania, United States, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, United States, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Bethlehem, Pennsylvania, United States, 18015
- Saint Luke's University Hospital-Bethlehem Campus
-
Bryn Mawr, Pennsylvania, United States, 19010
- Bryn Mawr Hospital
-
Danville, Pennsylvania, United States, 17822
- Geisinger Medical Center
-
Hazleton, Pennsylvania, United States, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hershey, Pennsylvania, United States, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Monroeville, Pennsylvania, United States, 15146
- Forbes Hospital
-
Natrona Heights, Pennsylvania, United States, 15065
- Allegheny Valley Hospital
-
Paoli, Pennsylvania, United States, 19301
- Paoli Memorial Hospital
-
Philadelphia, Pennsylvania, United States, 19111
- Fox Chase Cancer Center
-
Philadelphia, Pennsylvania, United States, 19140
- Temple University Hospital
-
Philadelphia, Pennsylvania, United States, 19107
- Pennsylvania Hospital
-
Pittsburgh, Pennsylvania, United States, 15224
- West Penn Hospital
-
State College, Pennsylvania, United States, 16801
- Geisinger Medical Group
-
West Reading, Pennsylvania, United States, 19611
- Reading Hospital
-
Wilkes-Barre, Pennsylvania, United States, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Wynnewood, Pennsylvania, United States, 19096
- Lankenau Medical Center
-
Wynnewood, Pennsylvania, United States, 19096
- Main Line Health NCORP
-
-
Rhode Island
-
Providence, Rhode Island, United States, 02905
- Women and Infants Hospital
-
-
South Carolina
-
Anderson, South Carolina, United States, 29621
- AnMed Health Cancer Center
-
Anderson, South Carolina, United States, 29621
- AnMed Health Hospital
-
Boiling Springs, South Carolina, United States, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Charleston, South Carolina, United States, 29425
- Medical University of South Carolina
-
Easley, South Carolina, United States, 29640
- Prisma Health Cancer Institute - Easley
-
Greenville, South Carolina, United States, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, United States, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, United States, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, United States, 29601
- Saint Francis Hospital
-
Greenville, South Carolina, United States, 29605
- Prisma Health Greenville Memorial Hospital
-
Greenville, South Carolina, United States, 29601
- Greenville Health System Cancer Institute-Andrews
-
Greenwood, South Carolina, United States, 29646
- Self Regional Healthcare
-
Greer, South Carolina, United States, 29650
- Prisma Health Cancer Institute - Greer
-
Greer, South Carolina, United States, 29651
- Gibbs Cancer Center-Pelham
-
Seneca, South Carolina, United States, 29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg, South Carolina, United States, 29303
- Spartanburg Medical Center
-
-
South Dakota
-
Rapid City, South Dakota, United States, 57701
- Black Hills Obstetrics and Gynecology
-
Sioux Falls, South Dakota, United States, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, United States, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, United States, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Knoxville, Tennessee, United States, 37920
- University of Tennessee - Knoxville
-
Nashville, Tennessee, United States, 37232
- Vanderbilt University/Ingram Cancer Center
-
-
Texas
-
Dallas, Texas, United States, 75235
- Parkland Memorial Hospital
-
Dallas, Texas, United States, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
Fort Worth, Texas, United States, 76104
- Baylor All Saints Medical Center at Fort Worth
-
Galveston, Texas, United States, 77555-0565
- University of Texas Medical Branch
-
Houston, Texas, United States, 77030
- Houston Methodist Hospital
-
-
Utah
-
Salt Lake City, Utah, United States, 84112
- Huntsman Cancer Institute/University of Utah
-
-
Vermont
-
Burlington, Vermont, United States, 05401
- University of Vermont Medical Center
-
-
Virginia
-
Fredericksburg, Virginia, United States, 22401
- Fredericksburg Oncology Inc
-
Richmond, Virginia, United States, 23298
- Virginia Commonwealth University/Massey Cancer Center
-
Roanoke, Virginia, United States, 24016
- Carilion Clinic Gynecological Oncology
-
-
Washington
-
Auburn, Washington, United States, 98001
- MultiCare Auburn Medical Center
-
Bellevue, Washington, United States, 98004
- Overlake Medical Center
-
Bellingham, Washington, United States, 98226
- PeaceHealth Medical Group PC
-
Bremerton, Washington, United States, 98310
- Harrison HealthPartners Hematology and Oncology-Bremerton
-
Bremerton, Washington, United States, 98310
- Harrison Medical Center
-
Centralia, Washington, United States, 98531
- Providence Regional Cancer System-Centralia
-
Everett, Washington, United States, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, United States, 98003
- Saint Francis Hospital
-
Lakewood, Washington, United States, 98499
- Saint Clare Hospital
-
Mount Vernon, Washington, United States, 98274
- Skagit Valley Hospital Regional Cancer Care Center
-
Olympia, Washington, United States, 98506-5166
- Providence - Saint Peter Hospital
-
Poulsbo, Washington, United States, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Puyallup, Washington, United States, 98372
- MultiCare Good Samaritan Hospital
-
Seattle, Washington, United States, 98109
- Fred Hutchinson Cancer Research Center
-
Seattle, Washington, United States, 98109
- Seattle Cancer Care Alliance
-
Seattle, Washington, United States, 98195
- University of Washington Medical Center - Montlake
-
Seattle, Washington, United States, 98112
- Kaiser Permanente Washington
-
Seattle, Washington, United States, 98104
- Pacific Gynecology Specialists
-
Seattle, Washington, United States, 98122-4307
- Swedish Medical Center-First Hill
-
Seattle, Washington, United States, 98133
- University of Washington Medical Center - Northwest
-
Sequim, Washington, United States, 98384
- Olympic Medical Cancer Care Center
-
Spokane, Washington, United States, 99202
- Cancer Care Northwest - Spokane South
-
Spokane, Washington, United States, 99204
- MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
-
Tacoma, Washington, United States, 98405
- MultiCare Tacoma General Hospital
-
Tacoma, Washington, United States, 98405
- MultiCare Allenmore Hospital
-
Tacoma, Washington, United States, 98405
- Saint Joseph Medical Center
-
Walla Walla, Washington, United States, 99362
- Providence Saint Mary Regional Cancer Center
-
Wenatchee, Washington, United States, 98801
- Wenatchee Valley Hospital and Clinics
-
-
Wisconsin
-
Grafton, Wisconsin, United States, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, United States, 54311
- Aurora BayCare Medical Center
-
La Crosse, Wisconsin, United States, 54601
- Gundersen Lutheran Medical Center
-
Madison, Wisconsin, United States, 53792
- University of Wisconsin Hospital and Clinics
-
Marinette, Wisconsin, United States, 54143
- Aurora Bay Area Medical Group-Marinette
-
Milwaukee, Wisconsin, United States, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, United States, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, United States, 53233
- Aurora Sinai Medical Center
-
Mukwonago, Wisconsin, United States, 53149
- ProHealth D N Greenwald Center
-
New Richmond, Wisconsin, United States, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, United States, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oshkosh, Wisconsin, United States, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Sheboygan, Wisconsin, United States, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Summit, Wisconsin, United States, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, United States, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, United States, 53188
- ProHealth Waukesha Memorial Hospital
-
West Allis, Wisconsin, United States, 53227
- Aurora West Allis Medical Center
-
-
Wyoming
-
Casper, Wyoming, United States, 82609
- Rocky Mountain Oncology
-
Sheridan, Wyoming, United States, 82801
- Welch Cancer Center
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
14 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
Female
Description
Inclusion Criteria:
- Patients must have newly diagnosed stage I-IV, persistent or recurrent (including unstaged) uterine carcinosarcoma (malignant mixed mullerian tumor-MMMT or with ovarian, fallopian tube or peritoneal carcinosarcoma and an enrollment date prior to 10/21/2013; pathology confirmed by site/institutional pathologist prior to enrollment) and be chemotherapy naïve as directed against their carcinosarcoma; unstaged patients (patients who have not had hysterectomy or ovarian surgery) are eligible and should be included as "unstaged" if the only histologic (pathology) documentation of the disease is a biopsy or curettage of the uterus; if these patients have documented metastatic disease, it should be assigned the appropriate stage (III/IV)
- Patients may have received prior adjuvant external beam radiation therapy and/or vaginal brachytherapy; patients should be at least 4 weeks from the completion of external beam radiotherapy prior to beginning protocol chemotherapy; patients do not need to be delayed if receiving vaginal brachytherapy only
- Gynecologic Oncology Group (GOG) performance status 0, 1, or 2
- Patients must have recovered from the effects of recent surgery, radiotherapy, or other therapy
- Patients must be free of active infection requiring antibiotics
- Any hormonal therapy directed at the malignant tumor must be discontinued at least one week prior to beginning protocol chemotherapy; continuation of hormone replacement therapy is permitted
- Platelet count greater than or equal to 100,000/mcL
- Absolute neutrophil count (ANC) greater than or equal to 1,500/mcL equivalent to Common Terminology Criteria for Adverse Events (CTCAE) version (v)3.0 grade 1
- Creatinine less than or equal to 1.5 times upper limit of normal (ULN), CTCAE v3.0 grade 1
- Bilirubin less than or equal to 1.5 times ULN (CTCAE v3.0 grade 1)
- Serum glutamic oxaloacetic transaminase (SGOT) less than or equal to 2.5 times ULN (CTCAE v3.0 grade 1)
- Alkaline phosphatase less than or equal to 2.5 times ULN (CTCAE v3.0 grade 1)
- Serum albumin should be equal to or greater than 3 g/dL
- Neuropathy (sensory and motor) less than or equal to CTCAE v3.0 grade 1
- Patients must have signed an approved informed consent and authorization permitting release of personal health information
- Patients of childbearing potential must have a negative serum pregnancy test prior to study entry and be practicing an effective form of contraception
- Patients may have measurable disease or non-measurable disease; measurable disease is defined as at least one lesion that can be accurately measured in at least one dimension (longest dimension to be recorded); each lesion must be >= 20 mm when measured by conventional techniques, including palpation, plain x-ray, computed tomography (CT), and magnetic resonance imaging (MRI), or >= 10 mm when measured by spiral CT; measurable disease patients must have at least one "target lesion" to be used to assess progression on this protocol as defined by Response Evaluation Criteria In Solid Tumors (RECIST); tumors within a previously irradiated field will be designated as "non-target" lesions unless progression is documented or a biopsy is obtained to confirm persistence at least 90 days following completion of radiation therapy
Exclusion Criteria:
- Patients who have received prior cytotoxic chemotherapy for management of uterine or ovarian carcinosarcoma
- Patients with a history of other invasive malignancies or with a concomitant invasive malignancy, with the exception of non-melanoma skin cancer, if there is any evidence of other malignancy being present within the last five years; patients are also ineligible if their previous cancer treatment contraindicates this protocol therapy
- Patients for whom radiotherapy is planned after or during chemotherapy prior to progression of cancer
- Patients with known hypersensitivity to Escherichia (E.) coli-derived drug preparations (pegfilgrastim and filgrastim [G-CSF])
- Patients with a known hypersensitivity to mesna or other thiol compounds
- For enrollment prior to 10/21/2013, patients who are not biopsy proven to have carcinosarcoma of the uterus, fallopian tube, peritoneum or ovary; for enrollment after 10/21/2013, patients who are not biopsy proven to have carcinosarcoma of the uterus
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
|---|---|
|
Experimental: Arm I (paclitaxel, carboplatin)
Patients receive paclitaxel IV over 3 hours followed by carboplatin IV over 30-60 minutes on day 1.
|
Given IV
Other Names:
Ancillary studies
Other Names:
Given IV
Other Names:
|
|
Experimental: Arm II (paclitaxel, ifosfamide)
Patients receive ifosfamide IV over 1 hour on days 1-3 followed by paclitaxel as in Arm I.
|
Given IV
Other Names:
Ancillary studies
Other Names:
Given IV
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Overall Survival
Time Frame: From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 115 months.
|
Measured in months from randomization to last contact or death.
Primary analysis was restricted to the eligible uterine carcinosarcoma cohort.
|
From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 115 months.
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Duration of Progression-free Survival
Time Frame: Approximately 9 years and 7 months
|
Measured in months from randomization to last contact or the earlier of the date of progression or death.
|
Approximately 9 years and 7 months
|
|
Incidence of Adverse Events as Assessed by CTCAE Version 3.0
Time Frame: Patients were assessed for adverse events during active protocol treatment and up to 30 days after the last cycle of treatment on the protocol.
|
Maximum grade experienced among all treated and eligible patients.
The grades are described by severity.
Grade 1 is the lowest (most mild) and Grade 5 being death (most severe).
Adverse events were analyzed across cohorts since disease site was considered independent of AEs.
|
Patients were assessed for adverse events during active protocol treatment and up to 30 days after the last cycle of treatment on the protocol.
|
|
Patient-Reported Quality of Life (QOL) - Baseline
Time Frame: Baseline - Prior to study treatment
|
Patient reported quality of life was measured with the Treatment Outcome Index (TOI) of the Functional Assessment of Cancer Therapy for endometrial cancer (FACT-En TOI).
The FACT-En TOI is a scale for assessing general QOL of endometrial cancer patients.
The FACT-En TOI score ranges 0-120 with a large score suggesting better QOL.
Quality of Life was analyzed across cohorts since disease site was considered independent of Quality of Life.
|
Baseline - Prior to study treatment
|
|
Patient Reported Quality of Life (QOL) - Post Baseline
Time Frame: Prior to cycle 3, Prior to cycle 6, 30 weeks post cycle 1.
|
Patient reported quality of life was measured with the Treatment Outcome Index (TOI) of the Functional Assessment of Cancer Therapy for endometrial cancer (FACT-En TOI).
The FACT-En TOI is a scale for assessing general QOL of endometrial cancer patients.
The FACT-En TOI score ranges 0-120 with a large score suggesting better QOL.
Quality of Life was analyzed across cohorts since disease site was considered independent of Quality of Life.
|
Prior to cycle 3, Prior to cycle 6, 30 weeks post cycle 1.
|
|
Patient Reported Peripheral Neuropathy Symptoms - Baseline
Time Frame: Baseline (Pre cycle 1)
|
Patient reported peripheral neuropathy symptoms was measured with the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group - neurotoxicity subscale (short version) (FACT/GOG-Ntx subscale).
The FACT/GOG-Ntx subscale contains 11 items.
Each item was scored using a 5-point scale (0=not at all; 1=a little bit; 2=somewhat; 3=quite a bit; 4=very much). .
The Ntx score ranges 0-44 with a large score suggesting less peripheral neuropathy symptoms.
Quality of Life was analyzed across cohorts since disease site was considered independent of Quality of Life.
|
Baseline (Pre cycle 1)
|
|
Patient-reported Peripheral Neuropathy Symptoms - Post Baseline
Time Frame: Prior to cycle 3, Prior to cycle 6, 30 weeks post cycle 1
|
Patient reported peripheral neuropathy symptoms was measured with the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group - neurotoxicity subscale (short version) (FACT/GOG-Ntx subscale).
The FACT/GOG-Ntx subscale contains 11 items.
Each item was scored using a 5-point scale (0=not at all; 1=a little bit; 2=somewhat; 3=quite a bit; 4=very much).
The Ntx score ranges 0-44 with a large score suggesting less peripheral neuropathy symptoms.Quality of Life was analyzed across cohorts since disease site was considered independent of Quality of Life.
|
Prior to cycle 3, Prior to cycle 6, 30 weeks post cycle 1
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Principal Investigator: Matthew A Powell, NRG Oncology
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
August 17, 2009
Primary Completion (Actual)
March 30, 2019
Study Registration Dates
First Submitted
August 6, 2009
First Submitted That Met QC Criteria
August 6, 2009
First Posted (Estimate)
August 7, 2009
Study Record Updates
Last Update Posted (Actual)
September 30, 2021
Last Update Submitted That Met QC Criteria
September 28, 2021
Last Verified
September 1, 2021
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Digestive System Diseases
- Pathologic Processes
- Neoplasms, Connective and Soft Tissue
- Neoplasms by Histologic Type
- Neoplasms
- Urogenital Neoplasms
- Neoplasms by Site
- Neoplasms, Glandular and Epithelial
- Peritoneal Diseases
- Genital Neoplasms, Female
- Endocrine System Diseases
- Disease Attributes
- Ovarian Diseases
- Adnexal Diseases
- Gonadal Disorders
- Digestive System Neoplasms
- Endocrine Gland Neoplasms
- Fallopian Tube Diseases
- Abdominal Neoplasms
- Neoplasms, Complex and Mixed
- Sarcoma
- Carcinoma
- Recurrence
- Ovarian Neoplasms
- Fallopian Tube Neoplasms
- Peritoneal Neoplasms
- Carcinosarcoma
- Mixed Tumor, Mullerian
- Carcinoma, Ovarian Epithelial
- Molecular Mechanisms of Pharmacological Action
- Antineoplastic Agents
- Tubulin Modulators
- Antimitotic Agents
- Mitosis Modulators
- Antineoplastic Agents, Alkylating
- Alkylating Agents
- Antineoplastic Agents, Phytogenic
- Carboplatin
- Paclitaxel
- Ifosfamide
- Isophosphamide mustard
- Albumin-Bound Paclitaxel
Other Study ID Numbers
- GOG-0261 (Other Identifier: CTEP)
- U10CA180868 (U.S. NIH Grant/Contract)
- U10CA027469 (U.S. NIH Grant/Contract)
- NCI-2011-01959 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
- CDR0000651458
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.