Cancer Pain Single Nucleotide Polymorphisms (SNPs)
December 23, 2014 updated by: Joost LM Jongen, Erasmus Medical Center
Storage and Analysis of Patient Blood-samples for Cancer Pain Research
Cancer pain is common in advanced cancer patients.
Opioids are the mainstay of treatment in cancer pain.
Responsiveness to and tolerability of opioids is, amongst others, determined by small variations in human DNA.
Using blood samples from clinically well-defined cancer pain patients, the investigators are going to analyze single nucleotide polymorphisms (SNPs) in genes that are known to be involved in responsiveness to opioids and sensitivity to pain.
Study Overview
Study Type
Observational
Enrollment (Actual)
243
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Zuid-Holland
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Rotterdam, Zuid-Holland, Netherlands, 3000CA
- Erasmus MC, Centrumlocatie en Daniel den Hoed
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (ADULT, OLDER_ADULT)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
Cancer pain patients in a large university hospital
Description
Inclusion Criteria:
- Cancer pain patients
Exclusion Criteria:
- Patients not able to provide informed consent
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
|---|
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Cancer Pain Patients
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
correlation between pain SNPs and equianalgesic opioid requirement
Time Frame: timepoint at blood sample
|
candidate SNP analysis
|
timepoint at blood sample
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Joost L Jongen, MD PhD, Erasmus Medical Center
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Helpful Links
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
September 1, 2008
Primary Completion (ACTUAL)
December 1, 2012
Study Completion (ACTUAL)
December 1, 2012
Study Registration Dates
First Submitted
August 10, 2009
First Submitted That Met QC Criteria
August 10, 2009
First Posted (ESTIMATE)
August 11, 2009
Study Record Updates
Last Update Posted (ESTIMATE)
December 24, 2014
Last Update Submitted That Met QC Criteria
December 23, 2014
Last Verified
December 1, 2014
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- MEC2008-166
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.