Motivation to Exercise in People With Anorexia Nervosa

December 4, 2012 updated by: New York State Psychiatric Institute

Behavioral Assessment of the Reinforcing Effects of Exercise in Patients With Anorexia Nervosa

The purpose of this research study is to determine the importance and level of physical activity in people with Anorexia Nervosa.

Study Overview

Status

Completed

Conditions

Anorexia Nervosa

Detailed Description

A laboratory paradigm that uses a progressive ratio computerized work task will be used to determine the reinforcing value of exercise in hospitalized patients with AN, both before and after weight gain. In addition, we will examine the relationship between the reinforcing value of exercise and free-living physical activity in this population. We will also examine the relationship between the reinforcing value of exercise and measures of depression, anxiety, and cortisol, which we have found in previous studies to be associated with other measures of physical activity and exercise motivation. In order to determine whether physical activity in women with AN differs from that of non-eating disordered women, we will extend studies of physical activity to free-living control participants. All adult patients and controls will undergo body composition assessment once to measure the association between physical activity and percent body fat. Finally, to determine the impact of exercise reinforcement and physical activity on outcome in women with AN, we will conduct follow-up assessments in all patient participants for one year after discharge from the inpatient treatment unit."

Study Type

Observational

Enrollment (Actual)

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

United States
- New York
  - New York, New York, United States, 10032
    - New York State Psychiatric Institute

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 45 years (Adult)

Accepts Healthy Volunteers

Genders Eligible for Study

Female

Sampling Method

Probability Sample

Study Population

Participants will be patients with anorexia nervosa on the inpatient unit at New York State Psychiatric Institute

Description

Inclusion Criteria:

DSM-IV diagnosis of Anorexia Nervosa (except amenorrhea)
Female
Age 18-45
Medically Stable for exercise participation
At a minimum of 75% Ideal Body Weight

Exclusion Criteria:

Significant or current past medical illness including diabetes mellitis and heart disease
Current or lifetime history or schizophrenia, bipolar disorder, or other psychotic disorder as defined by DSM-IV-TR
Current suicidal ideation or recent suicidal behavior (within past 3 months)
Drug or alcohol abuse in last 6 months
Taking psychotropic medication
Pregnancy

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
physical activity Time Frame: Physical activity before and after weight restoration	Physical activity before and after weight restoration

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

New York State Psychiatric Institute

Collaborators

National Institute of Mental Health (NIMH)

Investigators

Study Director: B. Timothy Walsh, MD, NYSPI
Principal Investigator: Evelyn Attia, MD, NYSPI

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

December 1, 2007

Primary Completion (Actual)

July 1, 2011

Study Completion (Actual)

July 1, 2011

Study Registration Dates

First Submitted

August 18, 2009

First Submitted That Met QC Criteria