- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00976625
Diastolic Dysfunction in Aortic Regurgitation
Persistent Diastolic Dysfunction Late After Valve Replacement in Severe Aortic Regurgitation
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Background
Patients with severe aortic regurgitation show eccentric LV hypertrophy and structural changes of the myocardium. Reversibility of functional and structural changes after successful valve replacement may be limited. Persistent diastolic dysfunction has been observed in the present study late after aortic valve replacement. This finding has been explained by incomplete regression of the extra-cellular matrix 7 years after valve replacement. Interstitial fibrosis remains unchanged compared to the preoperative situation but was increased early after operation due to the reduction in LV muscle mass. Regression of LV hypertrophy was 40% after 2 and 55% after 7 years of valve replacement. Myocardial muscle fibers decreased slightly but remained hypertrophied even late after operation. Interstitital fibrosis was found to be positively correlated to myocardial stiffness and inversely to LV ejection fraction.
Thus, persistent diastolic dysfunction with maintained systolic ejection performance can be observed late after successful valve replacement in patients with severe aortic regurgitation. Altered diastolic function has been associated with increased filling pressures during strenuous exercise with signs of dyspnea.
Objective
Evaluation of myocardial structure and function in patients with chronic volume overload before and after valve replacement(LV-remodeling).
Methods
Pressure-volume measurements and myocardial biopsy samples for assessing myocardial function and structure.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
-
Zürich, Switzerland, 8091
- Division of Cardiology
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Severe aortic regurgitation
- Successful valve replacement
- Informed consent
- Sinus rhythm
- No comorbidities
- No bundle branch block
- No pregnancy
Exclusion Criteria
- Unwillingness to undergo postop. cath
- diabetes mellitus
- arterial hypertension
- bleeding disorder
- pulmonary hypertension
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Non-Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Other: 2
|
Surgical valve replacement of the aorta
|
No Intervention: 1
Control group without intervention.
Treatment group with aortic valve replacement.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Cardiac function and structure
Time Frame: 7-10 years
|
7-10 years
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
LV hypertrophy and passive elastic properties
Time Frame: 7-10 years
|
7-10 years
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Hess, University of Bern
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- EK-32 16.9.1992 (Zürich)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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