- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01015833
Sorafenib Tosylate With or Without Doxorubicin Hydrochloride in Treating Patients With Locally Advanced or Metastatic Liver Cancer
Phase III Randomized Study of Sorafenib Plus Doxorubicin Versus Sorafenib in Patients With Advanced Hepatocellular Carcinoma (HCC)
Study Overview
Status
Conditions
- Unresectable Hepatocellular Carcinoma
- Advanced Adult Hepatocellular Carcinoma
- Recurrent Hepatocellular Carcinoma
- Stage IIIB Hepatocellular Carcinoma AJCC v7
- Stage IIIC Hepatocellular Carcinoma AJCC v7
- Stage IV Hepatocellular Carcinoma AJCC v7
- Stage III Hepatocellular Carcinoma AJCC v7
- Stage IIIA Hepatocellular Carcinoma AJCC v7
- Stage IVA Hepatocellular Carcinoma AJCC v7
- Stage IVB Hepatocellular Carcinoma AJCC v7
Detailed Description
PRIMARY OBJECTIVES:
I. Compare the overall survival (OS) of patients treated with sorafenib (sorafenib tosylate) and doxorubicin (doxorubicin hydrochloride) to that of those treated with sorafenib.
SECONDARY OBJECTIVES:
I. Compare time to progression (TTP) of patients treated with sorafenib and doxorubicin to that of those treated with sorafenib.
II. Compare progression-free-survival (PFS) of patients treated with sorafenib and doxorubicin to that of those treated with sorafenib.
III. Compare tumor response using Response Evaluation Criteria in Solid Tumors (RECIST) criteria of patients treated with sorafenib and doxorubicin to that of those treated with sorafenib.
OUTLINE: Patients are randomized to 1 of 2 treatment arms.
ARM I: Patients receive doxorubicin hydrochloride intravenously (IV) on day 1 and sorafenib tosylate orally (PO) once daily (QD) or twice daily (BID) on days 1-21. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity. After 6 courses, patients may continue to receive sorafenib tosylate PO QD or BID in the absence of disease progression or unacceptable toxicity.
ARM II: Patients receive sorafenib tosylate PO QD or BID on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 3 months for 1 year and then every 6 months for 2 years.
Study Type
Enrollment (Actual)
Phase
- Phase 3
Contacts and Locations
Study Locations
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Alberta
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Calgary, Alberta, Canada, T2N 4N2
- Tom Baker Cancer Centre
-
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British Columbia
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Vancouver, British Columbia, Canada, V5Z 4E6
- BCCA-Vancouver Cancer Centre
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Manitoba
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Winnipeg, Manitoba, Canada, R3E 0V9
- CancerCare Manitoba
-
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New Brunswick
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Moncton, New Brunswick, Canada, E1C 6Z8
- The Moncton Hospital
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Ontario
-
Kitchener, Ontario, Canada, N2G 1G3
- Grand River Regional Cancer Centre at Grand River Hospital
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London, Ontario, Canada, N6A 4L6
- London Regional Cancer Program
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Ottawa, Ontario, Canada, K1H 8L6
- Ottawa Hospital and Cancer Center-General Campus
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Toronto, Ontario, Canada, M5G 2M9
- University Health Network-Princess Margaret Hospital
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Quebec
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Montreal, Quebec, Canada, H3T 1E2
- Jewish General Hospital
-
Montreal, Quebec, Canada, H3H 2R9
- The Research Institute of the McGill University Health Centre (MUHC)
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Montreal, Quebec, Canada, H2W 1S6
- McGill University Department of Oncology
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Montreal, Quebec, Canada, H2X 3E4
- CHUM - Centre Hospitalier de l'Universite de Montreal
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Saskatchewan
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Saskatoon, Saskatchewan, Canada, S7N 4H4
- Saskatoon Cancer Centre
-
-
-
-
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San Juan, Puerto Rico, 00927
- Fundacion de Investigacion de Diego
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Alabama
-
Birmingham, Alabama, United States, 35233
- University of Alabama at Birmingham Cancer Center
-
Mobile, Alabama, United States, 36608
- Providence Hospital
-
Mobile, Alabama, United States, 36608
- Southern Cancer Center PC-Providence
-
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Alaska
-
Anchorage, Alaska, United States, 99508
- Alaska Regional Hospital
-
Fairbanks, Alaska, United States, 99701
- Fairbanks Memorial Hospital
-
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Arkansas
-
Jonesboro, Arkansas, United States, 72401
- Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
-
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California
-
Anaheim, California, United States, 92806
- Kaiser Permanente-Anaheim
-
Antioch, California, United States, 94531
- Kaiser Permanente-Deer Valley Medical Center
-
Arroyo Grande, California, United States, 93420
- PCR Oncology
-
Baldwin Park, California, United States, 91706
- Kaiser Permanente-Baldwin Park
-
Bellflower, California, United States, 90706
- Kaiser Permanente-Bellflower
-
Castro Valley, California, United States, 94546
- East Bay Radiation Oncology Center
-
Castro Valley, California, United States, 94546
- Valley Medical Oncology Consultants-Castro Valley
-
Clovis, California, United States, 93611
- Community Cancer Institute
-
Clovis, California, United States, 93611
- University Oncology Associates
-
Dublin, California, United States, 94568
- Epic Care-Dublin
-
Emeryville, California, United States, 94608
- Bay Area Breast Surgeons Inc
-
Emeryville, California, United States, 94608
- Epic Care Partners in Cancer Care
-
Fontana, California, United States, 92335
- Kaiser Permanente-Fontana
-
Fremont, California, United States, 94538
- Kaiser Permanente-Fremont
-
Fremont, California, United States, 94538
- Valley Medical Oncology Consultants-Fremont
-
Fresno, California, United States, 93720
- Kaiser Permanente-Fresno
-
Greenbrae, California, United States, 94904
- Marin Cancer Care Inc
-
Greenbrae, California, United States, 94904
- Marin General Hospital
-
Harbor City, California, United States, 90710
- Kaiser Permanente - Harbor City
-
Irvine, California, United States, 92618
- Kaiser Permanente-Irvine
-
Los Angeles, California, United States, 90027
- Kaiser Permanente Los Angeles Medical Center
-
Los Angeles, California, United States, 90034
- Kaiser Permanente West Los Angeles
-
Martinez, California, United States, 94553-3156
- Contra Costa Regional Medical Center
-
Modesto, California, United States, 95356
- Kaiser Permanente-Modesto
-
Mountain View, California, United States, 94040
- El Camino Hospital
-
Oakland, California, United States, 94611
- Kaiser Permanente-Oakland
-
Oakland, California, United States, 94609
- Alta Bates Summit Medical Center - Summit Campus
-
Oakland, California, United States, 94609
- Hematology and Oncology Associates-Oakland
-
Oakland, California, United States, 94602
- Highland General Hospital
-
Oakland, California, United States, 94609
- Tom K Lee Inc
-
Oakland, California, United States, 94609
- Bay Area Tumor Institute
-
Orange, California, United States, 92868
- UC Irvine Health/Chao Family Comprehensive Cancer Center
-
Orange, California, United States, 92868
- Saint Joseph Hospital - Orange
-
Panorama City, California, United States, 91402
- Kaiser Permanente - Panorama City
-
Pleasant Hill, California, United States, 94523
- East Bay Medical Oncology Hematology Medical Associates Inc-Pleasant Hill
-
Redwood City, California, United States, 94063
- Kaiser Permanente-Redwood City
-
Richmond, California, United States, 94801
- Kaiser Permanente-Richmond
-
Riverside, California, United States, 92505
- Kaiser Permanente-Riverside
-
Roseville, California, United States, 95661
- Kaiser Permanente-Roseville
-
Sacramento, California, United States, 95823
- Kaiser Permanente-South Sacramento
-
Sacramento, California, United States, 95825
- Kaiser Permanente - Sacramento
-
Salinas, California, United States, 93901
- Salinas Valley Memorial
-
San Diego, California, United States, 92120
- Kaiser Permanente-San Diego Zion
-
San Diego, California, United States, 92108
- Kaiser Permanente-San Diego Mission
-
San Francisco, California, United States, 94115
- Kaiser Permanente-San Francisco
-
San Francisco, California, United States, 94115
- UCSF Medical Center-Mount Zion
-
San Jose, California, United States, 95119
- Kaiser Permanente-Santa Teresa-San Jose
-
San Leandro, California, United States, 94577
- Kaiser Permanente San Leandro
-
San Marcos, California, United States, 92078
- Kaiser Permanente-San Marcos
-
San Pablo, California, United States, 94806
- Doctors Medical Center- JC Robinson Regional Cancer Center
-
San Rafael, California, United States, 94903
- Kaiser Permanente-San Rafael
-
Santa Clara, California, United States, 95051
- Kaiser Permanente Medical Center - Santa Clara
-
Santa Rosa, California, United States, 95403
- Kaiser Permanente-Santa Rosa
-
South San Francisco, California, United States, 94080
- Kaiser Permanente-South San Francisco
-
Stockton, California, United States, 95210
- Kaiser Permanente-Stockton
-
Vacaville, California, United States, 95688
- Kaiser Permanente Medical Center-Vacaville
-
Vallejo, California, United States, 94589
- Kaiser Permanente-Vallejo
-
Walnut Creek, California, United States, 94596
- Kaiser Permanente-Walnut Creek
-
Whittier, California, United States, 90602
- Presbyterian Intercommunity Hospital
-
Woodland Hills, California, United States, 91367
- Kaiser Permanente-Woodland Hills
-
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Colorado
-
Aurora, Colorado, United States, 80045
- University of Colorado Hospital
-
Denver, Colorado, United States, 80205
- Kaiser Permanente-Franklin
-
Glenwood Springs, Colorado, United States, 81601
- Valley View Hospital Cancer Center
-
Grand Junction, Colorado, United States, 81501
- Saint Mary's Hospital and Regional Medical Center
-
Lafayette, Colorado, United States, 80026
- Kaiser Permanente-Rock Creek
-
Lone Tree, Colorado, United States, 80124
- Kaiser Permanente-Lone Tree
-
Montrose, Colorado, United States, 81401
- Montrose Memorial Hospital
-
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Connecticut
-
Hartford, Connecticut, United States, 06105
- Smilow Cancer Hospital Care Center at Saint Francis
-
Middletown, Connecticut, United States, 06457
- Middlesex Hospital
-
New Haven, Connecticut, United States, 06520
- Yale University
-
-
Delaware
-
Lewes, Delaware, United States, 19958
- Beebe Medical Center
-
Newark, Delaware, United States, 19713
- Helen F Graham Cancer Center
-
Newark, Delaware, United States, 19713
- Delaware Clinical and Laboratory Physicians PA
-
Newark, Delaware, United States, 19713
- Medical Oncology Hematology Consultants PA
-
Newark, Delaware, United States, 19718
- Christiana Care Health System-Christiana Hospital
-
Newark, Delaware, United States, 19713
- Christiana Gynecologic Oncology LLC
-
Rehoboth Beach, Delaware, United States, 19971
- Beebe Health Campus
-
Seaford, Delaware, United States, 19973
- TidalHealth Nanticoke / Allen Cancer Center
-
Wilmington, Delaware, United States, 19801
- Christiana Care Health System-Wilmington Hospital
-
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District of Columbia
-
Washington, District of Columbia, United States, 20007
- MedStar Georgetown University Hospital
-
Washington, District of Columbia, United States, 20422
- Veterans Affairs Medical Center -Washington DC
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Florida
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Altamonte Springs, Florida, United States, 32701
- AdventHealth Altamonte
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Kissimmee, Florida, United States, 34744
- AdventHealth Kissimmee
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Lakeland, Florida, United States, 33805
- Lakeland Regional Health Hollis Cancer Center
-
Orlando, Florida, United States, 32803
- AdventHealth Orlando
-
Orlando, Florida, United States, 32822
- AdventHealth East Orlando
-
Pensacola, Florida, United States, 32504
- Sacred Heart Hospital
-
Winter Park, Florida, United States, 32792
- AdventHealth Winter Park
-
-
Georgia
-
Decatur, Georgia, United States, 30033
- Atlanta VA Medical Center
-
Macon, Georgia, United States, 31201
- Medical Center of Central Georgia
-
Savannah, Georgia, United States, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
-
Savannah, Georgia, United States, 31404
- Memorial Health University Medical Center
-
Savannah, Georgia, United States, 31404
- Summit Cancer Care-Memorial
-
Savannah, Georgia, United States, 31404
- Low Country Cancer Care
-
-
Hawaii
-
'Aiea, Hawaii, United States, 96701
- Pali Momi Medical Center
-
Honolulu, Hawaii, United States, 96813
- Queen's Medical Center
-
Honolulu, Hawaii, United States, 96817
- The Cancer Center of Hawaii-Liliha
-
Honolulu, Hawaii, United States, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
-
Honolulu, Hawaii, United States, 96813
- Straub Clinic and Hospital
-
Honolulu, Hawaii, United States, 96813
- University of Hawaii Cancer Center
-
Honolulu, Hawaii, United States, 96817
- Hawaii Cancer Care Inc-Liliha
-
Honolulu, Hawaii, United States, 96817
- Queen's Cancer Center - Kuakini
-
Honolulu, Hawaii, United States, 96826
- Kapiolani Medical Center for Women and Children
-
Honolulu, Hawaii, United States, 96819
- Kaiser Permanente Moanalua Medical Center
-
Wailuku, Hawaii, United States, 96793
- Maui Memorial Medical Center
-
Wailuku, Hawaii, United States, 96793
- Pacific Cancer Institute of Maui
-
-
Idaho
-
Boise, Idaho, United States, 83706
- Saint Alphonsus Cancer Care Center-Boise
-
Lewiston, Idaho, United States, 83501
- Saint Joseph Regional Medical Center
-
-
Illinois
-
Aurora, Illinois, United States, 60504
- Rush - Copley Medical Center
-
Bloomington, Illinois, United States, 61704
- Illinois CancerCare-Bloomington
-
Bloomington, Illinois, United States, 61701
- Saint Joseph Medical Center
-
Canton, Illinois, United States, 61520
- Illinois CancerCare-Canton
-
Carbondale, Illinois, United States, 62902
- Memorial Hospital of Carbondale
-
Carthage, Illinois, United States, 62321
- Illinois CancerCare-Carthage
-
Centralia, Illinois, United States, 62801
- Centralia Oncology Clinic
-
Chicago, Illinois, United States, 60611
- Northwestern University
-
Chicago, Illinois, United States, 60637
- University of Chicago Comprehensive Cancer Center
-
Chicago, Illinois, United States, 60612
- University of Illinois
-
Chicago, Illinois, United States, 60657
- UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital
-
Chicago, Illinois, United States, 60611
- Hematology and Oncology Associates
-
Danville, Illinois, United States, 61832
- Carle on Vermilion
-
Decatur, Illinois, United States, 62526
- Decatur Memorial Hospital
-
Decatur, Illinois, United States, 62526
- Cancer Care Specialists of Illinois - Decatur
-
Effingham, Illinois, United States, 62401
- Crossroads Cancer Center
-
Effingham, Illinois, United States, 62401
- Carle Physician Group-Effingham
-
Eureka, Illinois, United States, 61530
- Illinois CancerCare-Eureka
-
Galesburg, Illinois, United States, 61401
- Western Illinois Cancer Treatment Center
-
Galesburg, Illinois, United States, 61401
- Illinois CancerCare-Galesburg
-
Highland Park, Illinois, United States, 60035
- Hematology Oncology Associates of Illinois-Highland Park
-
Joliet, Illinois, United States, 60435
- Duly Health and Care Joliet
-
Joliet, Illinois, United States, 60432
- Midwest Center for Hematology Oncology
-
Kankakee, Illinois, United States, 60901
- Presence Saint Mary's Hospital
-
Kewanee, Illinois, United States, 61443
- Illinois CancerCare-Kewanee Clinic
-
La Grange, Illinois, United States, 60525
- AMITA Health Adventist Medical Center
-
Libertyville, Illinois, United States, 60048
- AMG Libertyville - Oncology
-
Macomb, Illinois, United States, 61455
- Illinois CancerCare-Macomb
-
Mattoon, Illinois, United States, 61938
- Carle Physician Group-Mattoon/Charleston
-
Mount Vernon, Illinois, United States, 62864
- Good Samaritan Regional Health Center
-
Niles, Illinois, United States, 60714
- Illinois Cancer Specialists-Niles
-
O'Fallon, Illinois, United States, 62269
- Cancer Care Center of O'Fallon
-
Oak Lawn, Illinois, United States, 60453-2699
- Advocate Christ Medical Center
-
Ottawa, Illinois, United States, 61350
- Illinois CancerCare-Ottawa Clinic
-
Ottawa, Illinois, United States, 61350
- Radiation Oncology of Northern Illinois
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Pekin, Illinois, United States, 61554
- Illinois CancerCare-Pekin
-
Pekin, Illinois, United States, 61554
- OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
-
Peoria, Illinois, United States, 61636
- Methodist Medical Center of Illinois
-
Peoria, Illinois, United States, 61637
- OSF Saint Francis Medical Center
-
Peoria, Illinois, United States, 61615
- Illinois CancerCare-Peoria
-
Peoria, Illinois, United States, 61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
-
Peru, Illinois, United States, 61354
- Illinois CancerCare-Peru
-
Peru, Illinois, United States, 61354
- Valley Radiation Oncology
-
Princeton, Illinois, United States, 61356
- Illinois CancerCare-Princeton
-
Rockford, Illinois, United States, 61114
- SwedishAmerican Regional Cancer Center/ACT
-
Rockford, Illinois, United States, 61104
- Swedish American Hospital
-
Skokie, Illinois, United States, 60076
- Hematology Oncology Associates of Illinois - Skokie
-
Springfield, Illinois, United States, 62781
- Memorial Medical Center
-
Springfield, Illinois, United States, 62702
- Southern Illinois University School of Medicine
-
Springfield, Illinois, United States, 62702
- Springfield Clinic
-
Springfield, Illinois, United States, 62702
- Central Illinois Hematology Oncology Center
-
Urbana, Illinois, United States, 61801
- Carle Cancer Center
-
Urbana, Illinois, United States, 61801
- The Carle Foundation Hospital
-
Yorkville, Illinois, United States, 60560
- Rush-Copley Healthcare Center
-
-
Indiana
-
Beech Grove, Indiana, United States, 46107
- Franciscan Saint Francis Health-Beech Grove
-
Elkhart, Indiana, United States, 46515
- Elkhart General Hospital
-
Elkhart, Indiana, United States, 46514
- Michiana Hematology Oncology PC-Elkhart
-
Elkhart, Indiana, United States, 46514-2098
- Elkhart Clinic
-
Fort Wayne, Indiana, United States, 46845
- Fort Wayne Medical Oncology and Hematology Inc-Parkview
-
Indianapolis, Indiana, United States, 46237
- Franciscan Health Indianapolis
-
Kokomo, Indiana, United States, 46904
- Community Howard Regional Health
-
La Porte, Indiana, United States, 46350
- IU Health La Porte Hospital
-
Michigan City, Indiana, United States, 46360
- Franciscan Saint Anthony Health-Michigan City
-
Michigan City, Indiana, United States, 46360
- Woodland Cancer Care Center
-
Mishawaka, Indiana, United States, 46545
- Memorial Regional Cancer Center Day Road
-
Mishawaka, Indiana, United States, 46545
- Michiana Hematology Oncology PC-Mishawaka
-
Mishawaka, Indiana, United States, 46545
- Cancer Care Partners LLC
-
Mishawaka, Indiana, United States, 46545
- Saint Joseph Regional Medical Center-Mishawaka
-
Plymouth, Indiana, United States, 46563
- Michiana Hematology Oncology PC-Plymouth
-
Richmond, Indiana, United States, 47374
- Reid Health
-
South Bend, Indiana, United States, 46601
- Memorial Hospital of South Bend
-
South Bend, Indiana, United States, 46601
- Michiana Hematology Oncology PC-South Bend
-
South Bend, Indiana, United States, 46628
- Northern Indiana Cancer Research Consortium
-
South Bend, Indiana, United States, 46617
- South Bend Clinic
-
Westville, Indiana, United States, 46391
- Michiana Hematology Oncology PC-Westville
-
-
Iowa
-
Ames, Iowa, United States, 50010
- McFarland Clinic PC - Ames
-
Ames, Iowa, United States, 50010
- Mary Greeley Medical Center
-
Bettendorf, Iowa, United States, 52722
- University of Iowa Healthcare Cancer Services Quad Cities
-
Boone, Iowa, United States, 50036
- McFarland Clinic PC-Boone
-
Clive, Iowa, United States, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, United States, 50325
- Medical Oncology and Hematology Associates-West Des Moines
-
Council Bluffs, Iowa, United States, 51503
- Alegent Health Mercy Hospital
-
Des Moines, Iowa, United States, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, United States, 50314
- Medical Oncology and Hematology Associates-Laurel
-
Fort Dodge, Iowa, United States, 50501
- McFarland Clinic PC-Trinity Cancer Center
-
Iowa City, Iowa, United States, 52242
- University of Iowa/Holden Comprehensive Cancer Center
-
Iowa City, Iowa, United States, 52246
- Iowa City VA Healthcare System
-
Jefferson, Iowa, United States, 50129
- McFarland Clinic PC-Jefferson
-
Marshalltown, Iowa, United States, 50158
- McFarland Clinic PC-Marshalltown
-
Ottumwa, Iowa, United States, 52501
- Ottumwa Regional Health Center
-
Sioux City, Iowa, United States, 51101
- Siouxland Regional Cancer Center
-
Sioux City, Iowa, United States, 51102
- Mercy Medical Center-Sioux City
-
Sioux City, Iowa, United States, 51104
- Saint Luke's Regional Medical Center
-
West Des Moines, Iowa, United States, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Chanute, Kansas, United States, 66720
- Cancer Center of Kansas - Chanute
-
Dodge City, Kansas, United States, 67801
- Cancer Center of Kansas - Dodge City
-
El Dorado, Kansas, United States, 67042
- Cancer Center of Kansas - El Dorado
-
Fort Scott, Kansas, United States, 66701
- Cancer Center of Kansas - Fort Scott
-
Independence, Kansas, United States, 67301
- Cancer Center of Kansas-Independence
-
Kansas City, Kansas, United States, 66112
- Providence Medical Center
-
Kingman, Kansas, United States, 67068
- Cancer Center of Kansas-Kingman
-
Lawrence, Kansas, United States, 66044
- Lawrence Memorial Hospital
-
Liberal, Kansas, United States, 67905
- Cancer Center of Kansas-Liberal
-
Manhattan, Kansas, United States, 66502
- Cancer Center of Kansas-Manhattan
-
McPherson, Kansas, United States, 67460
- Cancer Center of Kansas - McPherson
-
Newton, Kansas, United States, 67114
- Cancer Center of Kansas - Newton
-
Overland Park, Kansas, United States, 66209
- Menorah Medical Center
-
Overland Park, Kansas, United States, 66213
- Saint Luke's South Hospital
-
Parsons, Kansas, United States, 67357
- Cancer Center of Kansas - Parsons
-
Prairie Village, Kansas, United States, 66208
- Kansas City NCI Community Oncology Research Program
-
Pratt, Kansas, United States, 67124
- Cancer Center of Kansas - Pratt
-
Salina, Kansas, United States, 67401
- Cancer Center of Kansas - Salina
-
Shawnee Mission, Kansas, United States, 66204
- Advent Health - Shawnee Mission Medical Center
-
Topeka, Kansas, United States, 66606
- Cotton O'Neil Cancer Center / Stormont Vail Health
-
Wellington, Kansas, United States, 67152
- Cancer Center of Kansas - Wellington
-
Wichita, Kansas, United States, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, United States, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, United States, 67214
- Cancer Center of Kansas - Wichita
-
Wichita, Kansas, United States, 67208
- Associates In Womens Health
-
Wichita, Kansas, United States, 67214
- Wichita NCI Community Oncology Research Program
-
Wichita, Kansas, United States, 67214
- Wesley Medical Center
-
Winfield, Kansas, United States, 67156
- Cancer Center of Kansas - Winfield
-
-
Kentucky
-
Bardstown, Kentucky, United States, 40004
- Flaget Memorial Hospital
-
Corbin, Kentucky, United States, 40701
- Commonwealth Cancer Center-Corbin
-
Lexington, Kentucky, United States, 40536
- University of Kentucky/Markey Cancer Center
-
Lexington, Kentucky, United States, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, United States, 40509
- Saint Joseph Hospital East
-
Louisville, Kentucky, United States, 40202
- Jewish Hospital
-
Louisville, Kentucky, United States, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, United States, 40215
- Saints Mary and Elizabeth Hospital
-
Louisville, Kentucky, United States, 40215
- Doctors Carrol, Sheth, Raghavan
-
Shepherdsville, Kentucky, United States, 40165
- Jewish Hospital Medical Center South
-
-
Louisiana
-
Baton Rouge, Louisiana, United States, 70805
- LSU Health Baton Rouge-North Clinic
-
Baton Rouge, Louisiana, United States, 70809
- Louisiana Hematology Oncology Associates LLC
-
Baton Rouge, Louisiana, United States, 70809
- Mary Bird Perkins Cancer Center
-
Baton Rouge, Louisiana, United States, 70809
- Our Lady of the Lake Physicians Group - Medical Oncology
-
Baton Rouge, Louisiana, United States, 70809
- Ochsner Health Center-Summa
-
Baton Rouge, Louisiana, United States, 70806
- Baton Rouge General Medical Center
-
Baton Rouge, Louisiana, United States, 70809
- Hematology/Oncology Clinic PLLC
-
Covington, Louisiana, United States, 70433
- Ochsner Health Center-Covington
-
Houma, Louisiana, United States, 70360
- Mary Bird Perkins Cancer Center - Houma
-
Marrero, Louisiana, United States, 70072
- West Jefferson Medical Center
-
Metairie, Louisiana, United States, 70006
- Robert Veith MD LLC
-
New Orleans, Louisiana, United States, 70121
- Ochsner Medical Center Jefferson
-
New Orleans, Louisiana, United States, 70112
- Tulane University Health Sciences Center
-
New Orleans, Louisiana, United States, 70112
- University Medical Center New Orleans
-
New Orleans, Louisiana, United States, 70112
- Louisiana State University Health Science Center
-
Shreveport, Louisiana, United States, 71103
- LSU Health Sciences Center at Shreveport
-
-
Maine
-
York, Maine, United States, 03909
- York Hospital
-
-
Maryland
-
Baltimore, Maryland, United States, 21287
- Johns Hopkins University/Sidney Kimmel Cancer Center
-
Baltimore, Maryland, United States, 21215
- Sinai Hospital of Baltimore
-
Baltimore, Maryland, United States, 21204
- Greater Baltimore Medical Center
-
Baltimore, Maryland, United States, 21201
- University of Maryland/Greenebaum Cancer Center
-
Baltimore, Maryland, United States, 21229
- Saint Agnes Hospital
-
Bethesda, Maryland, United States, 20889-5600
- Walter Reed National Military Medical Center
-
Elkton, Maryland, United States, 21921
- Christiana Care - Union Hospital
-
Randallstown, Maryland, United States, 21133
- Northwest Hospital Center
-
-
Massachusetts
-
Boston, Massachusetts, United States, 02118
- Boston Medical Center
-
-
Michigan
-
Adrian, Michigan, United States, 49221
- Bixby Medical Center
-
Adrian, Michigan, United States, 49221
- Hickman Cancer Center
-
Ann Arbor, Michigan, United States, 48106
- Saint Joseph Mercy Hospital
-
Ann Arbor, Michigan, United States, 48106
- Michigan Cancer Research Consortium NCORP
-
Dearborn, Michigan, United States, 48124
- Beaumont Hospital - Dearborn
-
Detroit, Michigan, United States, 48236
- Ascension Saint John Hospital
-
Escanaba, Michigan, United States, 49829
- Green Bay Oncology - Escanaba
-
Flint, Michigan, United States, 48532
- Genesys Regional Medical Center-West Flint Campus
-
Flint, Michigan, United States, 48503
- Hurley Medical Center
-
Flint, Michigan, United States, 48503
- Genesys Hurley Cancer Institute
-
Grand Blanc, Michigan, United States, 48439
- Genesys Regional Medical Center
-
Iron Mountain, Michigan, United States, 49801
- Green Bay Oncology - Iron Mountain
-
Jackson, Michigan, United States, 49201
- Allegiance Health
-
Kalamazoo, Michigan, United States, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, United States, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, United States, 49048
- Borgess Medical Center
-
Lansing, Michigan, United States, 48912
- Sparrow Hospital
-
Livonia, Michigan, United States, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Monroe, Michigan, United States, 48162
- Mercy Memorial Hospital
-
Monroe, Michigan, United States, 48162
- Toledo Clinic Cancer Centers-Monroe
-
Niles, Michigan, United States, 49120
- Lakeland Hospital Niles
-
Pontiac, Michigan, United States, 48341
- Saint Joseph Mercy Oakland
-
Port Huron, Michigan, United States, 48060
- Lake Huron Medical Center
-
Saginaw, Michigan, United States, 48601
- Ascension Saint Mary's Hospital
-
Saint Joseph, Michigan, United States, 49085
- Lakeland Medical Center Saint Joseph
-
Saint Joseph, Michigan, United States, 49085
- Marie Yeager Cancer Center
-
Southfield, Michigan, United States, 48075
- Ascension Providence Hospitals - Southfield
-
Warren, Michigan, United States, 48093
- Saint John Macomb-Oakland Hospital
-
-
Minnesota
-
Brainerd, Minnesota, United States, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, United States, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, United States, 55433
- Mercy Hospital
-
Duluth, Minnesota, United States, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, United States, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, United States, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, United States, 55435
- Fairview Southdale Hospital
-
Fridley, Minnesota, United States, 55432
- Unity Hospital
-
Hutchinson, Minnesota, United States, 55350
- Hutchinson Area Health Care
-
Maplewood, Minnesota, United States, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, United States, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, United States, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, United States, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, United States, 55454
- Health Partners Inc
-
Minneapolis, Minnesota, United States, 55417
- Minneapolis VA Medical Center
-
New Ulm, Minnesota, United States, 56073
- New Ulm Medical Center
-
Robbinsdale, Minnesota, United States, 55422
- North Memorial Medical Health Center
-
Saint Louis Park, Minnesota, United States, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Louis Park, Minnesota, United States, 55416
- Metro Minnesota Community Oncology Research Consortium
-
Saint Paul, Minnesota, United States, 55101
- Regions Hospital
-
Saint Paul, Minnesota, United States, 55102
- United Hospital
-
Shakopee, Minnesota, United States, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, United States, 55082
- Lakeview Hospital
-
Waconia, Minnesota, United States, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, United States, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, United States, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
-
Mississippi
-
Hattiesburg, Mississippi, United States, 39401
- Hattiesburg Clinic - Hematology/Oncology Clinic
-
Hattiesburg, Mississippi, United States, 39404
- Forrest General Hospital / Cancer Center
-
Jackson, Mississippi, United States, 39216
- University of Mississippi Medical Center
-
-
Missouri
-
Bolivar, Missouri, United States, 65613
- Central Care Cancer Center - Bolivar
-
Bonne Terre, Missouri, United States, 63628
- Parkland Health Center-Bonne Terre
-
Branson, Missouri, United States, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, United States, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, United States, 63703
- Southeast Cancer Center
-
Columbia, Missouri, United States, 65212
- University of Missouri - Ellis Fischel
-
Columbia, Missouri, United States, 65201
- Veterans Administration
-
Independence, Missouri, United States, 64057
- Centerpoint Medical Center LLC
-
Jefferson City, Missouri, United States, 65109
- Capital Region Southwest Campus
-
Joplin, Missouri, United States, 64804
- Freeman Health System
-
Joplin, Missouri, United States, 64804
- Mercy Hospital Joplin
-
Kansas City, Missouri, United States, 64116
- North Kansas City Hospital
-
Kansas City, Missouri, United States, 64111
- Saint Luke's Hospital of Kansas City
-
Kansas City, Missouri, United States, 64132
- Research Medical Center
-
Kansas City, Missouri, United States, 64108
- Truman Medical Centers
-
Kansas City, Missouri, United States, 64118
- Heartland Hematology and Oncology Associates Incorporated
-
Kansas City, Missouri, United States, 64114
- Saint Joseph Health Center
-
Lee's Summit, Missouri, United States, 64086
- Saint Luke's East - Lee's Summit
-
Liberty, Missouri, United States, 64068
- Liberty Radiation Oncology Center
-
Rolla, Missouri, United States, 65401
- Delbert Day Cancer Institute at PCRMC
-
Rolla, Missouri, United States, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Saint Joseph, Missouri, United States, 64506
- Heartland Regional Medical Center
-
Saint Joseph, Missouri, United States, 64507
- Saint Joseph Oncology Inc
-
Saint Louis, Missouri, United States, 63110
- Washington University School of Medicine
-
Saint Louis, Missouri, United States, 63131
- Missouri Baptist Medical Center
-
Saint Louis, Missouri, United States, 63141
- Mercy Hospital Saint Louis
-
Saint Louis, Missouri, United States, 63109
- Saint Louis Cancer and Breast Institute-South City
-
Saint Louis, Missouri, United States, 63141
- Center for Cancer Care and Research
-
Saint Louis, Missouri, United States, 63141
- Comprehensive Cancer Care PC
-
Sainte Genevieve, Missouri, United States, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, United States, 65804
- Cancer Research for the Ozarks NCORP
-
Springfield, Missouri, United States, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, United States, 65804
- Mercy Hospital Springfield
-
Sullivan, Missouri, United States, 63080
- Missouri Baptist Sullivan Hospital
-
Sunset Hills, Missouri, United States, 63127
- Missouri Baptist Outpatient Center-Sunset Hills
-
-
Nebraska
-
Grand Island, Nebraska, United States, 68803
- CHI Health Saint Francis
-
Kearney, Nebraska, United States, 68847
- CHI Health Good Samaritan
-
Kearney, Nebraska, United States, 68845
- Heartland Hematology and Oncology
-
Lincoln, Nebraska, United States, 68510
- Saint Elizabeth Regional Medical Center
-
North Platte, Nebraska, United States, 69101
- Great Plains Health Callahan Cancer Center
-
Omaha, Nebraska, United States, 68114
- Nebraska Methodist Hospital
-
Omaha, Nebraska, United States, 68198
- University of Nebraska Medical Center
-
Omaha, Nebraska, United States, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, United States, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, United States, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, United States, 68131
- Creighton University Medical Center
-
Omaha, Nebraska, United States, 68122
- Hematology and Oncology Consultants PC
-
Papillion, Nebraska, United States, 68046
- Midlands Community Hospital
-
-
Nevada
-
Henderson, Nevada, United States, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, United States, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, United States, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, United States, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, United States, 89074
- GenesisCare USA - Henderson
-
Las Vegas, Nevada, United States, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, United States, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, United States, 89109
- GenesisCare USA - Las Vegas
-
Las Vegas, Nevada, United States, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, United States, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, United States, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, United States, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, United States, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, United States, 89148
- OptumCare Cancer Care at Fort Apache
-
Las Vegas, Nevada, United States, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, United States, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, United States, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, United States, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, United States, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, United States, 89121
- Cancer Therapy and Integrative Medicine
-
Las Vegas, Nevada, United States, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, United States, 89128
- GenesisCare USA - Vegas Tenaya
-
Las Vegas, Nevada, United States, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, United States, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, United States, 89148
- GenesisCare USA - Fort Apache
-
Las Vegas, Nevada, United States, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, United States, 89169
- Nevada Cancer Research Foundation NCORP
-
Reno, Nevada, United States, 89502
- Renown Regional Medical Center
-
Reno, Nevada, United States, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, United States, 89509
- Radiation Oncology Associates
-
Reno, Nevada, United States, 89511
- Cancer Care Specialists - Reno
-
-
New Hampshire
-
Lebanon, New Hampshire, United States, 03756
- Dartmouth Hitchcock Medical Center
-
-
New Jersey
-
Camden, New Jersey, United States, 08103
- Cooper Hospital University Medical Center
-
East Orange, New Jersey, United States, 07018-1095
- Veterans Adminstration New Jersey Health Care System
-
Mullica Hill, New Jersey, United States, 08062
- Inspira Medical Center Mullica Hill
-
Newark, New Jersey, United States, 07101
- Rutgers New Jersey Medical School
-
Vineland, New Jersey, United States, 08360
- Inspira Medical Center Vineland
-
-
New Mexico
-
Albuquerque, New Mexico, United States, 87102
- University of New Mexico Cancer Center
-
Las Cruces, New Mexico, United States, 88011
- Memorial Medical Center - Las Cruces
-
-
New York
-
Auburn, New York, United States, 13021
- Hematology Oncology Associates of Central New York-Auburn
-
Bronx, New York, United States, 10467
- Montefiore Medical Center - Moses Campus
-
Bronx, New York, United States, 10461
- Montefiore Medical Center-Weiler Hospital
-
Bronx, New York, United States, 10468
- James J Peters VA Medical Center
-
Brooklyn, New York, United States, 11209
- Veteran Affairs New York Harbor Healthcare System-Brooklyn Campus
-
Buffalo, New York, United States, 14215
- Veterans Affairs Western New York Health Care System-Buffalo
-
East Syracuse, New York, United States, 13057
- Hematology Oncology Associates of Central New York-East Syracuse
-
Glens Falls, New York, United States, 12801
- Glens Falls Hospital
-
Lake Success, New York, United States, 11042
- Northwell Health NCORP
-
Lake Success, New York, United States, 11042
- Northwell Health/Center for Advanced Medicine
-
Liverpool, New York, United States, 13088
- Hematology Oncology Associates of Central New York-Liverpool
-
Manhasset, New York, United States, 11030
- North Shore University Hospital
-
Middletown, New York, United States, 10940
- Garnet Health Medical Center
-
New Hyde Park, New York, United States, 11040
- Long Island Jewish Medical Center
-
New York, New York, United States, 10065
- Memorial Sloan Kettering Cancer Center
-
New York, New York, United States, 10019
- Mount Sinai West
-
New York, New York, United States, 10032
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
-
New York, New York, United States, 10065
- NYP/Weill Cornell Medical Center
-
New York, New York, United States, 10003
- Mount Sinai Union Square
-
Rochester, New York, United States, 14642
- University of Rochester
-
Rome, New York, United States, 13440
- Hematology Oncology Associates of Central New York-Rome
-
Stony Brook, New York, United States, 11794
- Stony Brook University Medical Center
-
Syracuse, New York, United States, 13210
- State University of New York Upstate Medical University
-
Syracuse, New York, United States, 13215
- Hematology Oncology Associates of Central New York-Onondaga Hill
-
Valhalla, New York, United States, 10595
- New York Medical College
-
-
North Carolina
-
Asheville, North Carolina, United States, 28801
- Mission Hospital
-
Asheville, North Carolina, United States, 28816
- Hope Women's Cancer Centers-Asheville
-
Asheville, North Carolina, United States, 28806
- Messino Cancer Centers
-
Asheville, North Carolina, United States, 28801
- Mountain Radiation Oncology PA
-
Asheville, North Carolina, United States, 28803
- AdventHealth Infusion Center Asheville
-
Brevard, North Carolina, United States, 28712
- Transylvania Regional Hospital
-
Charlotte, North Carolina, United States, 28204
- Novant Health Presbyterian Medical Center
-
Clinton, North Carolina, United States, 28328
- Southeastern Medical Oncology Center-Clinton
-
Clinton, North Carolina, United States, 28328
- Sampson Radiation Oncology
-
Franklin, North Carolina, United States, 28734
- Angel Medical Center
-
Goldsboro, North Carolina, United States, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, United States, 27534
- Wayne Memorial Hospital
-
Goldsboro, North Carolina, United States, 27534
- Wayne Radiation Oncology
-
Hendersonville, North Carolina, United States, 28792
- AdventHealth Hendersonville
-
Jacksonville, North Carolina, United States, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Jacksonville, North Carolina, United States, 28546
- Onslow Memorial Hospital
-
Kinston, North Carolina, United States, 28501
- Vidant Oncology-Kinston
-
Marion, North Carolina, United States, 28752
- Mission Hospital McDowell
-
Rutherfordton, North Carolina, United States, 28139
- Rutherford Hospital
-
Spruce Pine, North Carolina, United States, 28777
- Blue Ridge Regional Hospital
-
Statesville, North Carolina, United States, 28677
- Iredell Memorial Hospital
-
Winston-Salem, North Carolina, United States, 27157
- Wake Forest University Health Sciences
-
Winston-Salem, North Carolina, United States, 27104
- Southeast Clinical Oncology Research Consortium NCORP
-
-
North Dakota
-
Bismarck, North Dakota, United States, 58501
- Sanford Bismarck Medical Center
-
Bismarck, North Dakota, United States, 58501
- Mid Dakota Clinic
-
Bismarck, North Dakota, United States, 58501
- Saint Alexius Medical Center
-
Fargo, North Dakota, United States, 58103
- Essentia Health Cancer Center-South University Clinic
-
Minot, North Dakota, United States, 58701
- Trinity Cancer Care Center
-
-
Ohio
-
Akron, Ohio, United States, 44304
- Summa Health System - Akron Campus
-
Barberton, Ohio, United States, 44203
- Summa Health System - Barberton Campus
-
Bellefontaine, Ohio, United States, 43311
- Mary Rutan Hospital
-
Belpre, Ohio, United States, 45714
- Strecker Cancer Center-Belpre
-
Bowling Green, Ohio, United States, 43402
- Toledo Clinic Cancer Centers-Bowling Green
-
Canton, Ohio, United States, 44710
- Aultman Health Foundation
-
Chillicothe, Ohio, United States, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, United States, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, United States, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, United States, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, United States, 45255
- TriHealth Cancer Institute-Anderson
-
Cleveland, Ohio, United States, 44109
- MetroHealth Medical Center
-
Clyde, Ohio, United States, 43410
- North Coast Cancer Care-Clyde
-
Columbus, Ohio, United States, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, United States, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, United States, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, United States, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, United States, 43228
- Doctors Hospital
-
Columbus, Ohio, United States, 43213
- Mount Carmel East Hospital
-
Columbus, Ohio, United States, 43215
- Grant Medical Center
-
Columbus, Ohio, United States, 43222
- Mount Carmel Health Center West
-
Columbus, Ohio, United States, 43215
- Columbus NCI Community Oncology Research Program
-
Dayton, Ohio, United States, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, United States, 45409
- Miami Valley Hospital
-
Dayton, Ohio, United States, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, United States, 45405
- Grandview Hospital
-
Dayton, Ohio, United States, 45428
- Dayton Veterans Affairs Medical Center
-
Delaware, Ohio, United States, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, United States, 43015
- Delaware Radiation Oncology
-
Delaware, Ohio, United States, 43015
- Grady Memorial Hospital
-
Elyria, Ohio, United States, 44035
- Mercy Cancer Center-Elyria
-
Elyria, Ohio, United States, 44035
- Hematology Oncology Center Incorporated
-
Findlay, Ohio, United States, 45840
- Blanchard Valley Hospital
-
Franklin, Ohio, United States, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Greenville, Ohio, United States, 45331
- Wayne Hospital
-
Kettering, Ohio, United States, 45429
- Kettering Medical Center
-
Lancaster, Ohio, United States, 43130
- Fairfield Medical Center
-
Lancaster, Ohio, United States, 43130
- Lancaster Radiation Oncology
-
Lima, Ohio, United States, 45801
- Saint Rita's Medical Center
-
Lima, Ohio, United States, 45804
- Lima Memorial Hospital
-
Marietta, Ohio, United States, 45750
- Marietta Memorial Hospital
-
Maumee, Ohio, United States, 43537
- Toledo Clinic Cancer Centers-Maumee
-
Maumee, Ohio, United States, 43537
- Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
-
Maumee, Ohio, United States, 43537
- Saint Luke's Hospital
-
Mount Vernon, Ohio, United States, 43050
- Knox Community Hospital
-
Newark, Ohio, United States, 43055
- Licking Memorial Hospital
-
Newark, Ohio, United States, 43055
- Newark Radiation Oncology
-
Norwalk, Ohio, United States, 44857
- Fisher-Titus Medical Center
-
Oregon, Ohio, United States, 43616
- Saint Charles Hospital
-
Oregon, Ohio, United States, 43616
- Toledo Clinic Cancer Centers-Oregon
-
Portsmouth, Ohio, United States, 45662
- Southern Ohio Medical Center
-
Sandusky, Ohio, United States, 44870
- North Coast Cancer Care
-
Springfield, Ohio, United States, 45505
- Springfield Regional Medical Center
-
Sylvania, Ohio, United States, 43560
- ProMedica Flower Hospital
-
Tiffin, Ohio, United States, 44883
- Mercy Hospital of Tiffin
-
Toledo, Ohio, United States, 43606
- ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
-
Toledo, Ohio, United States, 43608
- Saint Vincent Mercy Medical Center
-
Toledo, Ohio, United States, 43623
- Mercy Health - Saint Anne Hospital
-
Toledo, Ohio, United States, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Toledo, Ohio, United States, 43614
- University of Toledo
-
Toledo, Ohio, United States, 43617
- Toledo Community Hospital Oncology Program CCOP
-
Troy, Ohio, United States, 45373
- Upper Valley Medical Center
-
Wauseon, Ohio, United States, 43567
- Fulton County Health Center
-
Westerville, Ohio, United States, 43081
- Saint Ann's Hospital
-
Wilmington, Ohio, United States, 45177
- Clinton Memorial Hospital
-
Xenia, Ohio, United States, 45385
- Greene Memorial Hospital
-
Zanesville, Ohio, United States, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Norman, Oklahoma, United States, 73071
- Cancer Care Associates-Norman
-
Oklahoma City, Oklahoma, United States, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, United States, 73120
- Mercy Physicians of Oklahoma-Lakeside
-
Tulsa, Oklahoma, United States, 74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
-
Oregon
-
Portland, Oregon, United States, 97227
- Kaiser Permanente Northwest
-
-
Pennsylvania
-
Abington, Pennsylvania, United States, 19001
- Jefferson Abington Hospital
-
Allentown, Pennsylvania, United States, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Butler, Pennsylvania, United States, 16001
- Butler Memorial Hospital
-
Pittsburgh, Pennsylvania, United States, 15240
- VA Pittsburgh Healthcare System
-
Sayre, Pennsylvania, United States, 18840
- Guthrie Medical Group PC-Robert Packer Hospital
-
West Reading, Pennsylvania, United States, 19611
- Reading Hospital
-
-
Rhode Island
-
Providence, Rhode Island, United States, 02908
- Roger Williams Medical Center
-
-
South Carolina
-
Anderson, South Carolina, United States, 29621
- AnMed Health Cancer Center
-
Anderson, South Carolina, United States, 29621
- AnMed Health Hospital
-
Boiling Springs, South Carolina, United States, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Easley, South Carolina, United States, 29640
- Prisma Health Cancer Institute - Easley
-
Greenville, South Carolina, United States, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, United States, 29607
- Saint Francis Cancer Center
-
Greenville, South Carolina, United States, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, United States, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, United States, 29601
- Saint Francis Hospital
-
Greenville, South Carolina, United States, 29605
- Prisma Health Greenville Memorial Hospital
-
Greenville, South Carolina, United States, 29601
- Greenville Health System Cancer Institute-Andrews
-
Greenwood, South Carolina, United States, 29646
- Self Regional Healthcare
-
Greer, South Carolina, United States, 29650
- Prisma Health Cancer Institute - Greer
-
Greer, South Carolina, United States, 29651
- Gibbs Cancer Center-Pelham
-
Lancaster, South Carolina, United States, 29720
- Carolina Blood and Cancer Care Associates PA-Lancaster
-
Rock Hill, South Carolina, United States, 29732
- Carolina Blood and Cancer Care Associates PA
-
Seneca, South Carolina, United States, 29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg, South Carolina, United States, 29303
- Spartanburg Medical Center
-
-
South Dakota
-
Rapid City, South Dakota, United States, 57701
- Rapid City Regional Hospital
-
Sioux Falls, South Dakota, United States, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, United States, 57117-5045
- Avera McKennan Hospital and University Health Center
-
-
Tennessee
-
Bristol, Tennessee, United States, 37620
- Wellmont Medical Associates Oncology and Hematology-Bristol
-
Bristol, Tennessee, United States, 37620
- Bristol Regional Medical Center
-
Chattanooga, Tennessee, United States, 37404
- Memorial Hospital
-
Hixson, Tennessee, United States, 37343
- Pulmonary Medicine Center of Chattanooga-Hixson
-
Jackson, Tennessee, United States, 38301
- Jackson-Madison County General Hospital
-
Kingsport, Tennessee, United States, 37660
- Ballad Health Cancer Care - Kingsport
-
Kingsport, Tennessee, United States, 37660
- Wellmont Holston Valley Hospital and Medical Center
-
Knoxville, Tennessee, United States, 37920
- University of Tennessee - Knoxville
-
Nashville, Tennessee, United States, 37208
- Meharry Medical College
-
Nashville, Tennessee, United States, 37203
- Nashville Oncology Associates PC
-
Ooltewah, Tennessee, United States, 37363
- Memorial GYN Plus
-
-
Texas
-
Amarillo, Texas, United States, 79106
- The Don and Sybil Harrington Cancer Center
-
El Paso, Texas, United States, 79905
- Texas Tech University Health Sciences Center-El Paso
-
Houston, Texas, United States, 77030
- Houston Methodist Hospital
-
Houston, Texas, United States, 77030
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
-
Houston, Texas, United States, 77030
- Michael E DeBakey VA Medical Center
-
Houston, Texas, United States, 77030
- Ben Taub General Hospital
-
Houston, Texas, United States, 77030
- Baylor Saint Luke's Medical Center
-
-
Vermont
-
Berlin, Vermont, United States, 05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington, Vermont, United States, 05405
- University of Vermont and State Agricultural College
-
White River Junction, Vermont, United States, 05009
- White River Junction Veteran Administration Medical Center
-
-
Virginia
-
Danville, Virginia, United States, 24541
- Danville Regional Medical Center
-
Fredericksburg, Virginia, United States, 22401
- Fredericksburg Oncology Inc
-
Martinsville, Virginia, United States, 24115
- Sovah Health Martinsville
-
Norton, Virginia, United States, 24273
- Southwest VA Regional Cancer Center
-
-
Washington
-
Anacortes, Washington, United States, 98221
- Cancer Care Center at Island Hospital
-
Auburn, Washington, United States, 98001
- MultiCare Auburn Medical Center
-
Bainbridge Island, Washington, United States, 98110
- Virginia Mason Bainbridge Island Medical Center
-
Bellevue, Washington, United States, 98004
- Overlake Medical Center
-
Bellingham, Washington, United States, 98225
- PeaceHealth Saint Joseph Medical Center
-
Bremerton, Washington, United States, 98310
- Harrison HealthPartners Hematology and Oncology-Bremerton
-
Bremerton, Washington, United States, 98310
- Harrison Medical Center
-
Burien, Washington, United States, 98166
- Highline Medical Center-Main Campus
-
Centralia, Washington, United States, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, United States, 98026
- Swedish Cancer Institute-Edmonds
-
Enumclaw, Washington, United States, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, United States, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, United States, 98002
- Virginia Mason Federal Way Medical Center
-
Federal Way, Washington, United States, 98003
- Saint Francis Hospital
-
Gig Harbor, Washington, United States, 98332
- Tacoma/Valley Radiation Oncology Centers-Gig Harbor
-
Gig Harbor, Washington, United States, 98335
- MultiCare Gig Harbor Medical Park
-
Issaquah, Washington, United States, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, United States, 99336
- Kadlec Clinic Hematology and Oncology
-
Kennewick, Washington, United States, 99336
- Northwest Cancer Clinic
-
Lacey, Washington, United States, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, United States, 98499
- Saint Clare Hospital
-
Lynnwood, Washington, United States, 98036
- Virginia Mason Lynnwood Medical Center
-
Mount Vernon, Washington, United States, 98274
- Skagit Valley Hospital
-
Olympia, Washington, United States, 98506-5166
- Providence - Saint Peter Hospital
-
Olympia, Washington, United States, 98507
- Capital Medical Center
-
Poulsbo, Washington, United States, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Poulsbo, Washington, United States, 98370
- Peninsula Cancer Center
-
Puyallup, Washington, United States, 98372
- MultiCare Good Samaritan Hospital
-
Puyallup, Washington, United States, 98372
- Tacoma/Valley Radiation Oncology Centers-Puyallup
-
Seattle, Washington, United States, 98109
- Fred Hutchinson Cancer Research Center
-
Seattle, Washington, United States, 98104
- Harborview Medical Center
-
Seattle, Washington, United States, 98101
- Virginia Mason Medical Center
-
Seattle, Washington, United States, 98195
- University of Washington Medical Center - Montlake
-
Seattle, Washington, United States, 98112
- Kaiser Permanente Washington
-
Seattle, Washington, United States, 98104
- Minor and James Medical PLLC
-
Seattle, Washington, United States, 98122-4307
- Swedish Medical Center-First Hill
-
Sedro-Woolley, Washington, United States, 98284
- PeaceHealth United General Medical Center
-
Spokane, Washington, United States, 99218
- Evergreen Hematology and Oncology PS
-
Spokane, Washington, United States, 99202
- Cancer Care Northwest - Spokane South
-
Spokane, Washington, United States, 99220
- Rockwood Clinic
-
Tacoma, Washington, United States, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, United States, 98405
- MultiCare Tacoma General Hospital
-
Tacoma, Washington, United States, 98405
- Tacoma/Valley Radiation Oncology Centers-Saint Joe's
-
Tacoma, Washington, United States, 97405
- Tacoma/Valley Radiation Oncology Centers-Jackson Hall
-
Tacoma, Washington, United States, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Tacoma, Washington, United States, 98405
- MultiCare Allenmore Hospital
-
Tacoma, Washington, United States, 98405
- Northwest NCI Community Oncology Research Program
-
Tacoma, Washington, United States, 98405
- Saint Joseph Medical Center
-
Wenatchee, Washington, United States, 98801
- Wenatchee Valley Hospital and Clinics
-
-
Wisconsin
-
Antigo, Wisconsin, United States, 54409
- Langlade Hospital and Cancer Center
-
Green Bay, Wisconsin, United States, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, United States, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Green Bay, Wisconsin, United States, 54303
- Green Bay Oncology Limited at Saint Mary's Hospital
-
Green Bay, Wisconsin, United States, 54301-3526
- Green Bay Oncology at Saint Vincent Hospital
-
La Crosse, Wisconsin, United States, 54601
- Gundersen Lutheran Medical Center
-
Manitowoc, Wisconsin, United States, 54221
- Holy Family Memorial Hospital
-
Marinette, Wisconsin, United States, 54143
- Bay Area Medical Center
-
Mukwonago, Wisconsin, United States, 53149
- ProHealth D N Greenwald Center
-
New Richmond, Wisconsin, United States, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, United States, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oconto Falls, Wisconsin, United States, 54154
- Saint Vincent Hospital Cancer Center at Oconto Falls
-
Sheboygan, Wisconsin, United States, 53081
- HSHS Saint Nicholas Hospital
-
Sturgeon Bay, Wisconsin, United States, 54235
- Green Bay Oncology - Sturgeon Bay
-
Waukesha, Wisconsin, United States, 53188
- ProHealth Waukesha Memorial Hospital
-
Wausau, Wisconsin, United States, 54401
- Aspirus Regional Cancer Center
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Patients must have pathologically or cytologically proven hepatocellular carcinoma; known mixed histology (e.g. hepatocellular carcinoma plus cholangiocarcinoma) or fibrolamellar variant is not allowed
- Patients must have locally advanced or metastatic disease; locally advanced disease is defined as disease deemed to be unresectable or non-eligible for transplant without distant metastases
- Lesions must be accurately measurable in at least one dimension (longest diameter to be recorded) as >= 2 cm with conventional techniques or as >= 1 cm with spiral computed tomography (CT) scan
- No prior adjuvant sorafenib or other v-RAF-1 murine leukemia viral oncogene homolog (Raf)/vascular endothelial growth factor (VEGF) inhibitors; other prior adjuvant therapy is allowed if completed > 6 months prior to registration with documented recurrence of hepatocellular carcinoma (HCC)
Patients may have been treated with loco regional therapies provided that they either have:
- A target lesion that has not been subjected to local therapy or
The target lesion(s) within the field of the local therapy has shown an increase of >= 20% in the size since last treatment
- Such therapy must be completed at least 4 weeks prior to registration; patients that have received palliative radiation therapy to the bone need not wait 4 weeks to begin protocol therapy
Prior therapies allowed include the following:
- Bland embolization, radiation, radioactive microspheres, etc
- Chemoembolization using any chemotherapy (except, see below)
- Chemoembolization drug-eluting beads using doxorubicin
- Prior therapy with chemoembolization using doxorubicin in the non drug eluting beads form is NOT allowed
- No prior systemic therapy for metastatic disease
- No prior exposure to systemic doxorubicin administered intravenously
- Antiviral treatment is allowed, however interferon therapy must be stopped at least 4 weeks prior to registration
- Allografts are not allowed: no prior history of any allograft, including but not limited to liver and bone marrow transplants
- Patients must have completed any major surgery >= 4 weeks from registration
- Concomitant treatment with Rifampin or St John's wort is not allowed; patients should discontinue these drugs at least 4 weeks prior to registration
- No known central nervous system (CNS) tumors including brain metastases
- No clinically significant gastrointestinal bleeding events requiring intervention, transfusion, or admission to hospital within 30 days prior to registration
- Patients with a history of hypertension should be well controlled (< 140/90 mmHg) on a regimen of anti-hypertensive therapy
Significant history of cardiac disease is not allowed:
- Congestive heart failure > class II New York Heart Association (NYHA)
- Myocardial infarction within 6 months prior to registration
- Serious myocardial dysfunction, defined as scintigraphically (multigated acquisition scan [MUGA], myocardial scintigram) determined absolute left ventricular ejection fraction (LVEF) below 45% or an LVEF on echocardiogram (ECHO) below the normal limit at the individual institution
- No history of bleeding diathesis
- Patients receiving combination anti-retroviral therapy for human immunodeficiency virus (HIV) are excluded from the study
- Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1
- Pregnancy/nursing status: women who are pregnant should not go on study; women should not breastfeed while participating in this study
- Granulocytes >= 1,500/uL
- Hemoglobin >= 8.5 g/dL; patients with recent or ongoing gastrointestinal bleed may not be transfused to reach the entry hemoglobin of 8.5 g/dL; physicians should ensure patients requiring transfusion prior to registration do not have an occult or clinically apparent gastrointestinal bleed
- Platelets >= 75,000/uL
- Creatinine =< 1.5 x upper limit of normal (ULN) (or creatinine clearance calculated >= 60 cc/minute)
- Child-Pugh score A; patients must meet all laboratory value requirements
- Bilirubin =< 3 mg/dL
- Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 5 x ULN
- Prothrombin time (PT)-international normalized ratio (INR) =< 1.7 (not required for patients on anticoagulation agents; patients who are being therapeutically anticoagulated with an agent such as Coumadin or heparin will be allowed to participate provided that no prior evidence of underlying abnormality in these parameters exists)
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Arm I (doxorubicin hydrochloride, sorafenib tosylate)
Patients receive doxorubicin hydrochloride IV on day 1 and sorafenib tosylate PO QD or BID on days 1-21.
Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity.
After 6 courses, patients may continue to receive sorafenib tosylate PO QD or BID in the absence of disease progression or unacceptable toxicity.
|
Correlative studies
Correlative studies
Other Names:
Given IV
Other Names:
Given PO
Other Names:
|
Experimental: Arm II (sorafenib tosylate)
Patients receive sorafenib tosylate PO QD or BID on days 1-21.
Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
|
Correlative studies
Correlative studies
Other Names:
Given PO
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Overall Survival
Time Frame: Up to 3 years
|
Overall survival is defined as the time from study entry to death from any cause.
The median OS was estimated using the Kaplan-Meier method.
|
Up to 3 years
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Incidence of Toxicities, as Assessed by National Cancer Institute Common Terminology Criteria for Adverse Events Version 4.0
Time Frame: Up to 3 years
|
Toxicity is defined as a grade 3 or higher adverse events that is classified as either possibly, probably, or definitely related to study treatment.
The assignment of attribution to study treatment and grade (or degree of severity) of the adverse event are classified using the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 4.0.
The maximum grade for each type of adverse event will be recorded for each patient, and frequency tables will be reviewed to determine patterns.
Additionally, the relationship of the adverse event(s) to the study treatment will be taken into consideration.
The percentage of patients with a maximum grade 3 or higher adverse event at least possibly related to the study treatment are reported below.
|
Up to 3 years
|
Progression Free Survival
Time Frame: Up to 3 years
|
Progression free survival is defined as the time from study entry to earliest date of disease progression.
Progression is defined as at least a 20% increase in the sum of the diameters of target lesions, taking as reference the smallest sum on study (this includes the baseline sum if that is the smallest on study).
In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of at least 5 mm.
(Note: The appearance of one or more new lesions is also considered progression).
|
Up to 3 years
|
Time to Progression (TTP)
Time Frame: Up to 3 years
|
Time to Progression (TTP) is defined as the time from on study to progression.
Progression is defined by the RECIST criteria as Progressive Disease (PD): At least a 20% increase in the sum of the diameters of target lesions, taking as reference the smallest sum on study (this includes the baseline sum if that is the smallest on study).
In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of at least 5 mm.
(Note: The appearance of one or more new lesions is also considered progression).
Median and 95% confidence intervals are provided for each arm below.
|
Up to 3 years
|
Best Overall Response Rate
Time Frame: Up to 3 years
|
Best Overall Response Rate is defined as is the best response recorded from the start of the treatment until disease progression/recurrence.
Complete Response: Disappearance of all target lesions.
Any pathological lymph nodes must have reduction in short axis to < 10 mm.
Partial Response (PR): At least a 30% decrease in the sum of the diameters of target lesions, taking as reference the baseline sum diameters.
Progressive Disease (PD): At least a 20% increase in the sum of the diameters of target lesions, taking as reference the smallest sum on study (this includes the baseline sum if that is the smallest on study).
In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of at least 5 mm.
(Note: The appearance of one or more new lesions is also considered progression).
Stable Disease (SD): Neither sufficient shrinkage to qualify for PR nor sufficient increase to qualify for PD taking as references the smallest sum diameters while on study.
|
Up to 3 years
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Ghassan K Abou-Alfa, Alliance for Clinical Trials in Oncology
Publications and helpful links
General Publications
- Quintanilha JCF, Geyer S, Etheridge AS, Racioppi A, Hammond K, Crona DJ, Pena CE, Jacobson SB, Marmorino F, Rossini D, Cremolini C, Sanoff HK, Abou-Alfa GK, Innocenti F. KDR genetic predictor of toxicities induced by sorafenib and regorafenib. Pharmacogenomics J. 2022 Dec;22(5-6):251-257. doi: 10.1038/s41397-022-00279-3. Epub 2022 Apr 28.
- Abou-Alfa GK, Shi Q, Knox JJ, Kaubisch A, Niedzwiecki D, Posey J, Tan BR Jr, Kavan P, Goel R, Lammers PE, Bekaii-Saab TS, Tam VC, Rajdev L, Kelley RK, El Dika I, Zemla T, Potaracke RI, Balletti J, El-Khoueiry AB, Harding JJ, Suga JM, Schwartz LH, Goldberg RM, Bertagnolli MM, Meyerhardt J, O'Reilly EM, Venook AP. Assessment of Treatment With Sorafenib Plus Doxorubicin vs Sorafenib Alone in Patients With Advanced Hepatocellular Carcinoma: Phase 3 CALGB 80802 Randomized Clinical Trial. JAMA Oncol. 2019 Nov 1;5(11):1582-1588. doi: 10.1001/jamaoncol.2019.2792. Erratum In: JAMA Oncol. 2019 Oct 10;:
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Digestive System Diseases
- Neoplasms by Histologic Type
- Neoplasms
- Neoplasms by Site
- Adenocarcinoma
- Neoplasms, Glandular and Epithelial
- Digestive System Neoplasms
- Liver Diseases
- Liver Neoplasms
- Carcinoma
- Carcinoma, Hepatocellular
- Molecular Mechanisms of Pharmacological Action
- Enzyme Inhibitors
- Antineoplastic Agents
- Topoisomerase II Inhibitors
- Topoisomerase Inhibitors
- Protein Kinase Inhibitors
- Antibiotics, Antineoplastic
- Sorafenib
- Doxorubicin
- Liposomal doxorubicin
Other Study ID Numbers
- NCI-2011-01989 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
- U10CA180821 (U.S. NIH Grant/Contract)
- U10CA031946 (U.S. NIH Grant/Contract)
- CDR0000659348
- CALGB-80802 (Other Identifier: CTEP)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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