Hypodontia and Ovarian Cancer

October 31, 2013 updated by: University of Aarhus

Hypodontia and Ovarian Cancer - the Connection Between Dental Agenesis and Epithelial Cancers, Especially Ovarian Cancer.

The purpose of this project is to examine whether the risk of developing ovarian cancer is increased in Danish women with congenital missing teeth as a result of their failure to develop (hypodontia). Should this prove to be the case, these women could be offered regular clinical controls and prophylactic removal of their ovaries when menopause enters and the ovaries are no longer functional (producing hormones).

If there is a connection between congenital hypodontia and the development of different types of cancer, the investigators will perform a genetic screening in families with increased risk of cancer and hypodontia for changes in relevant genes, based on the current literature. The investigators hereby search for new genes, which in a changed form leads to an increased risk of cancer and thereby enables us to perform genetic screening in risk families.

Study Overview

Status

Unknown

Conditions

Study Type

Observational

Enrollment (Anticipated)

200

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

  • Name: Jan Blaakaer, Professor
  • Phone Number: +4578450000
  • Email: jab@dadlnet.dk

Study Locations

  • Denmark
    • Aarhus
      • Skejby, Aarhus, Denmark, 8000
    • Copenhagen
      • Copenhagen Ø, Copenhagen, Denmark, 2100

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

Female

Sampling Method

Probability Sample

Study Population

All women referred to the department of obstetrics/gynecology under the diagnosis ovarian cancer obs. pro.

Description

Inclusion Criteria:

  • confirmed suspicion of ovarian cancer.

Exclusion Criteria:

  • suspicion of ovarian cancer disproved.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Case-Control
  • Time Perspectives: Retrospective

Cohorts and Interventions

Group / Cohort
Ovarian Cancer

Women treated for ovarian cancer at the departments of obstetrics and gynecology, Aarhus University Hospital and Rigshospitalet, Copenhagen.

Expected recruitment: 200
Control patients

Women referred to the departments of obstetrics and gynecology in Aarhus University Hospital and Rigshospitalet, Copenhagen on benign indication.

Expected recruitment: 200.
HBOC/HNPCC

Patients registered in the large Danish Register of HBOC( hereditary breast and ovarian cancer) and HNPCC (hereditary nonpolyposis colorectal cancer).

Expected recruitment: 200.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Prevalence rates of hypodontia in women with ovarian cancer
Time Frame: one year
one year

Secondary Outcome Measures

Outcome Measure
Time Frame
Genetic causes for hypodontia and ovarian cancer
Time Frame: two years
two years
Prevalence rates of hypodontia in patients with a known risk for epithelial cancer
Time Frame: one year
one year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Aarhus

Collaborators

Danish Cancer Society
Arvid-Nilsson Foundation

Investigators

  • Study Director: Jan Blaakaer, Professor, MD, DMSc, Aarhus University Hospital
  • Principal Investigator: Maria Cathrine C. V. Schmidt, MD, Ph.d.-student, Aarhus University Hospital
  • Study Chair: Charlotte Soegaard, MD, ph.d., Aarhus University Hospital
  • Study Chair: Lone Sunde, Associate Professor, PhD, Aarhus University Hospital
  • Study Chair: Claus Hoegdall, Professor, Copenhagen University Hospital at Herlev
  • Study Chair: Michala O. Lexner, Dentist, PhD

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

September 1, 2011

Primary Completion (Anticipated)

September 1, 2014

Study Completion (Anticipated)

August 1, 2015

Study Registration Dates

First Submitted

November 9, 2011

First Submitted That Met QC Criteria

November 9, 2011

First Posted (Estimate)

November 11, 2011

Study Record Updates

Last Update Posted (Estimate)

November 1, 2013

Last Update Submitted That Met QC Criteria

October 31, 2013

Last Verified

October 1, 2013

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Hypodontovariancancer2011

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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