Mapping Multidimensional Illness Trajectories of Patients With End-stage Kidney Disease

Mapping Multidimensional Illness Trajectories of Patients With ESKD

Patients with end-stage kidney disease (ESKD) must manage not only the demands of dialysis and comorbid conditions but also associated symptoms and acute life-threatening events that contribute to functional limitations and increased risk of mortality. Yet little is known about the trajectories of quality of life dimensions in patients with ESKD when they experience acute life-threatening episodes, to guide palliative care for this population. In this prospective, descriptive study, we will identify trajectories of symptoms, physical functioning, psychosocial needs, and emotional and spiritual well-being in 200 patients with ESKD who are at a high risk of experiencing acute life-threatening events and mortality within 12 months.

Study Overview

• Status: Completed
• Conditions: End Stage Kidney Disease

• Study Type: Observational
• Enrollment (Actual): 227

Contacts and Locations

Study Locations

• United States
  • North Carolina
    • Chapel Hill, North Carolina, United States, 27514
      • UNC Hospitals and outpatient dialysis clinics

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

ESKD patients who have been on dialysis

Description

Inclusion Criteria:

• aged 18 years or older;
• receiving either Hemodialysis or Peritoneal dialysis
• on dialysis either < 3 months or ≥ 6 months with a Charlson Comorbidity Index (CCI) score ≥ 5

Exclusion Criteria:

• Patients who are enrolled in hospice or too sick to participate in questionnaire completion will not be eligible.
• Kidney transplant candidates will be excluded because their illness trajectories after transplant are likely to differ.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Symptoms, physical functioning, psychosocial needs, spiritual well-being, cognitive functioning	12 months

Collaborators and Investigators

• Sponsor: University of North Carolina, Chapel Hill
• Collaborators: National Institute of Nursing Research (NINR)
• Investigators: Principal Investigator: Mi-Kyung Song, PhD, RN, FAAN, University of North Carolina, Chapel Hill

Study record dates

Study Major Dates

• Study Start: March 1, 2012
• Primary Completion (Actual): July 1, 2015
• Study Completion (Actual): July 1, 2015

Study Registration Dates

• First Submitted: February 7, 2012
• First Submitted That Met QC Criteria: February 9, 2012
• First Posted (Estimate): February 10, 2012

Study Record Updates

• Last Update Posted (Estimate): September 4, 2015
• Last Update Submitted That Met QC Criteria: September 2, 2015
• Last Verified: September 1, 2015

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Urologic Diseases; Renal Insufficiency; Renal Insufficiency, Chronic; Kidney Diseases; Kidney Failure, Chronic
• Other Study ID Numbers: R01NR013359 (U.S. NIH Grant/Contract)