Description of Abdominal and Gluteo-femoral Subcutaneous Adipose Tissue Cell Population in Women - GLUTAB
August 27, 2025 updated by: Institut National de la Santé Et de la Recherche Médicale, France
Description Des Populations Cellulaires Des Tissus Adipeux Sous-cutanés Abdominaux et glutéo-fémoraux Chez la Femme.
The purpose of this study is to compare, in healthy women, the adipose tissue composition between abdomen and thigh and then determine whether differences exist independently of the state of obesity.
The findings of this study may help to explain the mechanism contributing to a beneficial role of gluteo-femoral fat contrasting with a deleterious role of abdominal fat on cardiovascular and metabolic dysfunctions.
Study Overview
Study Type
Interventional
Enrollment (Actual)
20
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Toulouse, France, 31059
- Centre d'Investigation Clinique, CHU Purpan
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
25 years to 45 years (Adult)
Accepts Healthy Volunteers
Yes
Description
Inclusion Criteria:
- women between 15 and 45 years old
- with genital activity
- stable weight during the previous 3 months
- BMI from 20 to 28
- regular menstrual cycles (28 +/- 2 days) during the previous 3 months
- reliable means of contraception (systemic hormonal contraception, intrauterine contraceptive device, tubal ligation)
- using the same way of contraception during the previous 3 months
- normal clinical examination
- able to be compliant with the schedule of protocol assessments
- willing and able to provide written informed consent
- affiliated to a National Health Service
- agreeing to being registered on the national file for subjects participating in biomedical research
Exclusion Criteria:
- Exclusions related to significant medical disturbances :
- type I and II diabetes
- early menopause
- serious psychological disorders
- uncontrolled thyroid disorders
- know allergy to local anesthetics especially Xylocaine
- abnormal laboratory results
- medical history that, in the opinion of the investigator, makes the subject unsuitable for enrollment
- positive test result for HIV, HCV and/or HBV virus
- positive pregnancy test
- Exclusions related to subject lifestyle :
- smoking > 10 cigarettes per day
- smoking cessation during the previous 3 months
- weight fluctuation (>3kg) during the previous 3 months
- alcohol abuse
- coffee or tea consumption > 6 cups per day
- high consumption of drinks comprising xanthine bases (>0.5 liters/day)
- consumption of drinks (water or herbal teas) > 2 liters per day
- Exclusions related to previous or concomitant treatments :
- anticoagulant
- neuroleptic or antidepressant
- medication with draining, lipolytic, appetite suppressant and/or slimming effect
- local or systemic corticosteroid therapy on the test areas
- hormonal treatment other than contraception
- diuretic
- local treatment against cellulitis (mesotherapy,phosphatidylcholine injection, mechanical process)
- thighs liposuction < 2 years
- chronic treatment with anti-inflammatory
- Exclusions related to the subject :
- unwillingness or inability to comply with the requirements of the protocol
- previous participation in a clinical trial within 30 days
- inability to understand and sign the consent due to linguistic or psychic issues
- subject deprived of liberty or under guardianship, tutorship or judicial protection
- female who are currently pregnant or breastfeeding or female considering becoming pregnant while in the study
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: N/A
- Interventional Model: Single Group Assignment
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
|---|---|
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Other: Non-menoposal healthy volunteer women aged between 25 to 45 years
Adipose tissue biopsie (2-3g) have been taken by needle biopsy form the abdomen (periumbilical) and gluteo-femoral (upper thigh) levels
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Abdominal and gluteo-femoral subcutaneous adipose tissue biopsies
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
|---|---|
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To compare the number and the phenotype of cells between abdominal and gluteo-femoral adipose tissue in women.
Time Frame: There is no time frame. It's a comparison of adipose tissue composition between two locations, collected both at visit 2 (inclusion).
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There is no time frame. It's a comparison of adipose tissue composition between two locations, collected both at visit 2 (inclusion).
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Claire Thalamas, Doctor, CHU Purpan (Toulouse)
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
May 14, 2012
Primary Completion (Actual)
December 14, 2012
Study Completion (Actual)
December 14, 2012
Study Registration Dates
First Submitted
May 11, 2012
First Submitted That Met QC Criteria
May 21, 2012
First Posted (Estimated)
May 25, 2012
Study Record Updates
Last Update Posted (Estimated)
September 4, 2025
Last Update Submitted That Met QC Criteria
August 27, 2025
Last Verified
March 1, 2025
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- C11-48
- 2011-A01496-35 (Registry Identifier: IDRCB)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.