Obesity-related Genes in Taiwanese Undergoing Weight Loss

September 11, 2012 updated by: Sung Ling Yeh

Searching for the Most Influential Obesity-related Diabetic Genes and Exploring the Expression Profiles of Those Genes in Taiwanese Undergoing Weight Loss

To investigate:

  1. Associations between miRNA and insulin signaling-related gene expressions in abdominal adipose tissues in obese subjects.
  2. Differences in miRNAs expressed by intrabdominal omental adipose tissues between genders.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Compared the differences in microRNA expressions of abdominal adipose tissue in morbid obese male and female subjects to elucidate the possible regulatory role of microRNA in insulin signaling-related gene expression levels and its association with biochemical markers. We hope to find a miRNA that can be used to predict the syndrome associated with obesity.

Study Type

Observational

Enrollment (Actual)

20

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Taiwan
      • Taipei, Taiwan, 110
        • Taipei Medical University Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

19 years to 63 years (Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

Paired samples of abdominal subcutaneous and intrabdominal omental adipose tissue were obtained from men (n = 9) and women (n =10) who underwent bariatric surgery. Their BMI were all over 40 kg/ m2, and ages between 19-63 years.

Description

Inclusion Criteria:

  • Morbid obesity,BMIs> 40 kg/m2
  • Subjects who underwent bariatric surgery

Exclusion Criteria:

  • Obese subjects with complicated metabolic disorders
  • Thyroid disease

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
gender
Paired samples of abdominal subcutaneous and intrabdominal omental adipose tissue were obtained from men and women who underwent bariatric surgery.
Genetic: gender
Paired samples of abdominal subcutaneous and intrabdominal omental adipose tissue were obtained from men and women who underwent bariatric surgery.
Other Names:
  • BMI were all over 40 kg/ m2

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
MicroRNA expression in abdominal omental adipose tissues
Time Frame: up to 28 weeks
MicroRNA-125a-3p expression in abdominal omental adipose tissues is associated with insulin signaling-related gene expression levels in morbid obesity
up to 28 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sung Ling Yeh

Collaborators

National Science Council, Taiwan

Investigators

  • Study Director: Wang Weu, Comprehensive Weight Management Center Taipei Medical University Hospital

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

June 1, 2010

Primary Completion (Actual)

September 1, 2010

Study Completion (Actual)

September 1, 2010

Study Registration Dates

First Submitted

September 10, 2012

First Submitted That Met QC Criteria

September 10, 2012

First Posted (Estimate)

September 12, 2012

Study Record Updates

Last Update Posted (Estimate)

September 13, 2012

Last Update Submitted That Met QC Criteria

September 11, 2012

Last Verified

September 1, 2012

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • CRC-06-09-10

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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