Measurement of Retinal Venous Pressure Under Short-term Low-oxygen Environment

Measurement of Retinal Venous Pressure (Retinal Venous Pressure RVP) Under Conditions of Reduced Ambient Pressure and Oxygen Partial Pressure

The hypothesis is that the pressure in the retinal veins increases under a short-term lack of oxygen and leads to a decreased blood circulation. On the basis of measurements in the hypobaric chamber this hypothesis should be verified.

Study Overview

• Status: Completed
• Conditions: Healthy

Detailed Description

Conduct a pilot study to describe and quantify the retinal venous pressure (RVP) in healthy volunteers under conditions of controlled, reduced ambient and oxygen partial pressure in the pressure chamber of the Aeromedical Institute FAI in Dübendorf, Switzerland. Obtaining evidence of the adaptation behavior of the retinal vascular system in controlled, short-term hypoxic changes.

• Study Type: Observational
• Enrollment (Actual): 24

Contacts and Locations

Study Locations

• Switzerland
  • Basel, Switzerland, 4031
    • University of Basel, Dept. of Ophthalmology

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 60 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

healthy volunteers

Description

Inclusion Criteria:

• healthy

Exclusion Criteria:

• eye diseases
• systemic diseases
• term medication (except contraceptives)
• pregnancy
• allergies to the ingredients Alcain, Tropicamide and Phenylephrine
• blood pressure levels except standard (<60 /> 140 mmHg)
• oxygen saturation (SO2) <90%

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Retinal venous pressure	Quantify the changes in the retinal venous pressure (RVP)	1 hour

Collaborators and Investigators

• Sponsor: University Hospital, Basel, Switzerland
• Investigators: Study Director: Josef Flammer, MD, University of Basel, Dept. of Ophthalmology

Study record dates

Study Major Dates

• Study Start: December 1, 2011
• Primary Completion (Actual): May 1, 2014
• Study Completion (Actual): July 1, 2014

Study Registration Dates

• First Submitted: October 24, 2012
• First Submitted That Met QC Criteria: January 16, 2013
• First Posted (Estimate): January 18, 2013

Study Record Updates

• Last Update Posted (Estimate): July 21, 2014
• Last Update Submitted That Met QC Criteria: July 18, 2014
• Last Verified: July 1, 2014

More Information

Terms related to this study

• Keywords: retinal venous pressure; reduced ambient pressure; oxygen partial pressure; short-term hypoxic changes
• Other Study ID Numbers: USB-2011-327