Cardiovascular and Renal Microvascular Outcome Study With Linagliptin in Patients With Type 2 Diabetes Mellitus (CARMELINA)

March 21, 2019 updated by: Boehringer Ingelheim

CARMELINA: A Multicenter, International, Randomized, Parallel Group, Double-blind, Placebo-controlled, Cardiovascular Safety and Renal Microvascular Outcome Study With Linagliptin, 5 mg Once Daily in Patients With Type 2 Diabetes Mellitus at High Vascular Risk

The aim of the study is to investigate the longterm impact on cardiovascular morbidity, mortality and renal function of treatment with linagliptin in a selected population of patients with Type 2 diabetes mellitus (T2DM) and to compare outcomes against placebo, on a background of standard of care.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

6991

Phase

  • Phase 4

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Argentina
      • Adrogue, Argentina, B1846DSK
        • Instituto Médico Adrogué
      • Bahia Blanca, Argentina, B8001HXM
        • Hospital Italiano Regional del Sur, Bahia Blanca
      • Bahia Blanca, Argentina, 8000
        • Hospital Interzonal General de Agudos Dr Jose Penna
      • Bahia Blanca, Argentina, B8000FTD
        • Inst de Inv Clinicas-Bahia Blanca
      • Caba, Argentina, C1419GEP
        • Hospital Sirio-Libanes
      • Ciudad Autonoma Buenos Aires, Argentina, C1119ACN
        • CIPREC
      • Ciudad Autonoma Buenos Aires, Argentina, C1430CKE
        • CCBR - Buenos Aires - AR
      • Ciudad Autonoma Buenos Aires, Argentina, C1428ART
        • Instituto Cardiovascular de Buenos Aires
      • Ciudad Autonoma Buenos Aires, Argentina, C1056ABJ
        • Centro de Investigaciones Metabólicas
      • Ciudad Autonoma Buenos Aires, Argentina, C1181ACH
        • Hospital Italiano
      • Ciudad Autonoma Buenos Aires, Argentina, C1425AGC
        • Consultorios Asociados de Endocrinología e Invest Clínica
      • Ciudad Autonoma Buenos Aires, Argentina, C1425DES
        • CEDIC - Centro de Investigacion Clinica
      • Ciudad Autonoma de Bs As, Argentina, C1120AAC
        • Centro Medico Viamonte
      • Cordoba, Argentina, X5004CDT
        • Hospital Cordoba
      • Cordoba, Argentina, X5000AAW
        • Inst. Privado de Inv. Clinicas de Cordoba
      • Cordoba, Argentina, X5008KKF
        • IPAC - Clínica Privada Caraffa SRL
      • Cordoba, Argentina, 5000
        • Centro Médico Colón
      • Cordoba, Argentina, 5008
        • CEMAIC - Centro Medico Especializado
      • Cordoba, Argentina, X5002AOQ
        • Clínica Colombo
      • Cordoba, Argentina, X5003DCE
        • Instituto DAMIC - Fundacion Rusculleda
      • Cordoba, Argentina, X5020AAA
        • Clinica Privada del Prado
      • Corrientes, Argentina, W3400
        • Centro Universitario de Investigacion Corrientes
      • Córdoba, Argentina, X5000JHQ
        • Sanatorio Allende S.A.
      • Godoy Cruz, Argentina, 5501
        • CIPADI
      • Haedo, Argentina, B1706CZA
        • Centro Medico Dr. Javier Marino
      • La Plata, Argentina, B1900AXI
        • Hospital Italiano de La Plata
      • Mar del Plata, Argentina, B7602CBM
        • Hospital Privado De Comunidad
      • Mar del Plata, Argentina, B7600FEN
        • Unidad de Cardiologia Clinica
      • Mendoza, Argentina, 5500
        • Hospital Central de Mendoza, Mendoza
      • Parana, Argentina, E3100BBJ
        • Hospital San Martin
      • Pellegrini 661, Argentina, S2600KUE
        • Sanatorio San Martin S.A., Venado Tuerto
      • Quilmes, Argentina, B1878DVB
        • Cer Instituto Medico
      • Quilmes, Argentina, B1878GEG
        • Instituto de Investigaciones Clínicas de Quilmes
      • Rosario, Argentina, 2000
        • Instituto de Investigaciones Clinicas de Rosario
      • Rosario, Argentina, 2000
        • Instituto Medico Fundación Grupo Colaborativo Rosario
      • Rosario, Argentina, 2000
        • Sanatorio Británico
      • Rosario, Argentina, S2000PBJ
        • Instituto CAICI
      • Rosario, Argentina, 2000
        • Instituto Medico de la Fundacion Estudios Clinicos, Rosario
      • Rosario, Argentina, 2000
        • Sanatorio Norte
      • Rosario, Argentina, CP2000
        • Instituto de Hematologia y Medicina Clinica Ruben Davoli
      • Rosario, Argentina, S2000BIF
        • Sanatorio Delta
      • Rosario, Argentina, S2000DEJ
        • Centro Medico CIR
      • Rosario, Argentina, S2000DNM
        • CEDyN
      • Rosario, Argentina, S2000QID
        • Instituto Medico CENICLAR-C de Investigaciones Clinicas
      • Salta, Argentina, A4400ANW
        • CORDIS S.A., Salta
      • Salta, Argentina, 4406
        • Centro Cardiovascular Salta
      • Salta, Argentina, A4400CRC
        • Prevencion Cardiovascular Salta, Salta
      • San Miguel de Tucuman, Argentina, T4000
        • CCBR Tucuman
      • San Miguel de Tucumán, Argentina, T4000ICL
        • Investigaciones Clinicas Tucuman
      • San Nicolas, Argentina, B2900DMH
        • Instituto de Investigaciones Clinicas San Nicolas
      • San Vicente, Argentina, X5006CBI
        • Centro Medico Luquez
      • Santa Fe, Argentina, S3000FWO
        • Centro de Investigaciones Clínicas del Litoral
      • Santa Fé, Argentina, S3000EOZ
        • Hospital "Dr. José Maria Cullen "
      • Villa Maria, Argentina, X5900JKA
        • Clinica Privada Fusavim SRL
      • Zarate, Argentina, 2800
        • Instituto de Investigaciones Clínicas Zarate
  • Brazil
      • Belo Horizonte, Brazil, 30110-060
        • Hospital Felicio Rocho
      • Belo Horizonte, Brazil, 30110-921
        • Hospital Lifecenter
      • Belo Horizonte, Brazil, 30140-062
        • Hospital Vera Cruz
      • Belém, Brazil, 66073-000
        • Hospital Universitário João de Barros Barreto
      • Campina Grande do Sul, Brazil, 83430-000
        • Hospital Angelina Caron
      • Campinas, Brazil, 13060-904
        • HMCP - Hospital e Maternidade Celso Pierro - PUC-Campinas
      • Campinas, Brazil, 13087-567
        • CAEP - Centro Avançado de Estudos e Pesquisas Ltda.,Campinas
      • Canoas, Brazil, 92425-900
        • Hospital Universitario
      • Caxias do Sul, Brazil, 95070-560
        • Universidade de Caxias do Sul - IPCEM - Inst. de Pesq.clilni
      • Curitiba, Brazil, 80010-030
        • Hospital de Caridade Santa Casa de Misericordia de Curitiba
      • Curitiba, Brazil, 80030-110
        • HC UFPR
      • Curitiba, Brazil, 80030-480
        • Cruz Vermelha Brasileira - Filial do Estado do Paraná
      • Fortaleza, Brazil, 60115-282
        • Centro de Estudos Em Diabetes E Hipertensão
      • Fortaleza, Brazil, 60430-350
        • Centro de Pesquisas em Diabetes e Doenças
      • Fortaleza, Brazil, 60430-370
        • ICE-HUWC - Instituto Cearense de Endocrinologia
      • Goiania, Brazil, 74223-130
        • Via Medica
      • Lajeado, Brazil, 95900-000
        • Hospital Bruno Born
      • Marília, Brazil, 17515-000
        • ICM - Instituto do Coracao de Marilia
      • Passo Fundo, Brazil, 99010-080
        • Hospital Sao Vicente de Paulo
      • Porto Alegre, Brazil, 90035-074
        • Irmandade da Santa Casa de Misericórdia de Porto Alegre
      • Porto Alegre, Brazil, 90035-170
        • Centro de Pesquisas em Diabetes
      • Porto Alegre, Brazil, 90620-001
        • Instituto de Cardiologia Rio Grande do Sul
      • Recife, Brazil, 52020-010
        • Centro de Pesquisas Médicas Básica e Clínica Ltda
      • Rio de Janeiro, Brazil, 22271-100
        • CCBR - Rio de Janeiro - BR
      • Santa Maria, Brazil, 97015-530
        • Centro de Pesquisa Clínica Santa Maria
      • Santo Andre, Brazil, 09190510
        • CCBR Brasil - São Paulo
      • Sao Jose do Rio Preto, Brazil, 15015-750
        • Instituto Domingo Braile
      • Sao Jose do Rio Preto, Brazil, 15090-000
        • Fundacao Faculdade Regional de Medicina, Sao Jose
      • Sao Paulo, Brazil, 01244-030
        • Centro de Pesquisa Clinica - CPCLIN
      • Sao Paulo, Brazil, 01327-010
        • FGM Clinica Paulista de Doencas Cardiovasculares Ltda
      • Sao Paulo, Brazil, 04022-001
        • Hospital São Paulo - UNIFESP
      • São Paulo, Brazil, 01323-903
        • Hospital Alemao Oswaldo Cruz
      • São Paulo, Brazil, 05403-000
        • Hospital das Clínicas da FMUSP
      • São Paulo, Brazil, 01228-000
        • CPQuali Pesquisa Clínica Ltda
      • São Paulo, Brazil, 04039-901
        • Hospital do Servidor Público Estadual
      • São Paulo, Brazil, 04254-020
        • Dr. Consulta
      • São Paulo, Brazil, 05403-000
        • Incor - Instituto do Coração - HCFMUSP
      • Tatui, Brazil, 18270-170
        • IMC - Instituto de Moléstias Cardiovasculares Tatuí
      • Uberlândia, Brazil, 38400-368
        • ICT - Instituto do Coração do Triângulo
  • Bulgaria
      • Blagoevgrad, Bulgaria, 2700
        • MHAT - Blagoevgrad, EOOD
      • Byala, Bulgaria, 7100
        • MHAT "Yuliya Vrevska" EOOD, Byala
      • Kazanlak, Bulgaria, 6100
        • MHAT "Dr.Stambolski", Cardiology&Intensiv Care Dept,Kazanlak
      • Plovdiv, Bulgaria, 4002
        • UMHAT "Kaspela", EOOD, Plovdiv
      • Ruse, Bulgaria, 7002
        • DCC 1 - Ruse, EOOD
      • Sofia, Bulgaria, 1407
        • MHAT 'Tokuda Hospital Sofia', EAD
      • Sofia, Bulgaria, 1336
        • MHAT Lyulin
      • Sofia, Bulgaria, 1233
        • Fifth MHAT - Sofia EAD, Sofia
      • Sofia, Bulgaria, 1431
        • USHATE Hospital 'Academy Ivan Penchev', Sofia
      • Varna, Bulgaria, 9000
        • DCC "Equita" EOOD
  • Canada
      • Quebec, Canada, G1V 4M6
        • Clinique des maladies lipidiques de Quebec
      • Quebec, Canada, G1G 3Y8
        • Recherche Clinique Sigma Inc.
    • Alberta
      • Edmonton, Alberta, Canada, T5A 4L8
        • ALTA Clinical Research Inc.
      • Red Deer, Alberta, Canada, T4N 6V7
        • The Bailey Clinic
    • British Columbia
      • Burnaby, British Columbia, Canada, V5G 1T4
        • Dr. Ronald Collette
      • Penticton, British Columbia, Canada, V2A5G8
        • The Medical Arts Health Research Group
      • Vancouver, British Columbia, Canada, V6J 1S3
        • LMC Clinical Research dba Manna Research Inc. Vancouver
      • Victoria, British Columbia, Canada, V8T 5G4
        • Discovery Clinical Services Ltd.
      • Victoria, British Columbia, Canada, V8R 4R2
        • Fraser Clinical Trials Inc.
      • Victoria, British Columbia, Canada, V8V 4A1
        • CookMed Research
    • Manitoba
      • Winnipeg, Manitoba, Canada, R3E 3P4
        • Winnipeg Regional Health Authority, Winnipeg
    • Nova Scotia
      • Halifax, Nova Scotia, Canada, B3S 1M7
        • True North Clinical Research Halifax, Inc.
    • Ontario
      • Barrie, Ontario, Canada, L4N 7L3
        • LMC Endocrinology Centres (Barrie) Ltd.
      • Burlington, Ontario, Canada, L7M 4Y1
        • JBN Medical Diagnostic Services Inc.
      • Etobicoke, Ontario, Canada, M9R 4E1
        • LMC Endocrinology Centres (Etobicoke) Ltd.
      • Markham, Ontario, Canada, L6B 0P9
        • LMC Endocrinology Centres (Markham) Ltd.
      • Newmarket, Ontario, Canada, L3Y 5G8
        • SKDS Research Incorporated
      • Sudbury, Ontario, Canada, P3E 3B8
        • Dr. R. Labonte Prof. Med. Corp
      • Sudbury, Ontario, Canada, P3E 1H5
        • Medicor Research
      • Sudbury, Ontario, Canada, P3E 2N8
        • Sudbury Cardiac Research
    • Quebec
      • Brossard, Quebec, Canada, J4Z 2K9
        • ViaCar Recherche Clinique Inc
      • Greenfield Park, Quebec, Canada, J4V 2G9
        • Hopital Charles - LeMoyne
      • Laval, Quebec, Canada, H7T 2P5
        • Centre de Recherche Clinique
      • Longueuil, Quebec, Canada, J4N 1C2
        • Recherche Invascor Inc.
      • Montreal, Quebec, Canada, H2X 0A9
        • Centre Hospitalier de l'Universite de Montreal (CHUM)
      • Montreal, Quebec, Canada, H4A 3J1
        • McGill University Health Centre (MUHC)
      • St-Jerome, Quebec, Canada, J7Z 5T3
        • St Jerome Medical Research Inc.
      • Ville Saint-Laurent, Quebec, Canada, H4T 1Z9
        • LMC Endocrinology Centres (Montreal)
  • Chile
      • Punta Arenas, Chile, 6200000
        • Hospital Regional de Punta Arenas Dr. Lautaro Navarro Avaria
      • Santiago, Chile, 8150000
        • Hospital Sótero del Río
      • Santiago, Chile, 7850000
        • Hospital Militar de Santiago
      • Santiago, Chile
        • Hospital El Pino
      • Santiago, Chile
        • Sociedad Medica Cardiologica El Llano
      • Santiago, Chile, 8331143
        • CeCim - Centro de Estudios Clinicos e Investigacion Medica
      • Santiago, Chile, 8880465
        • Hospital Padre Alberto Hurtado
      • Valdivia, Chile, 5090000
        • Hospital Base Valdivia
      • Viña del Mar, Chile, 2520000
        • Hospital Naval Almirante Nef
  • China
      • Beijing, China, 100035
        • Beijing Jishuitan Hospital
      • Guangzhou, China, 510150
        • Third Affiliated Hospital of Guangzhou Medical University
      • Hangzhou, China, 310016
        • Zhejiang University School Of Medicine Sir Run Run Shaw Hospital
      • Jinan, China, 250013
        • Center Hospital of Jinan
      • Nanning, China, 530021
        • People's Hospital of Guangxi Zhuang Autonomous Region
      • Shanghai, China, 200065
        • Tongji Hospital, Tongji University
      • Xi'an, China, 710061
        • First Affiliated Hospital of Xi'an JiaoTong University
      • Yinchuan, China, 750004
        • General Hospital of Ningxia Medical University
  • Colombia
      • Armenia, Colombia, 55860
        • CEQUIN
      • Barranquilla, Colombia, 0000
        • Corazon IPS S.A.S.
      • Barranquilla, Colombia
        • Clínica de la costa Ltda.
      • Barranquilla, Colombia, 80020
        • IPS Centro Cientifico Asistencia
      • Bogota, Colombia, 110221
        • Solano y Terront Servicios Médicos Ltda.
      • Bogota, Colombia
        • Centro de Atencion e Investigacion Medica S.A. - CAIMED
      • Bogota, Colombia, 110221
        • CAFESALUD Medicina Prepagada S.A.
      • Bogotá, Colombia, 110221
        • Dexa Diabetes Servicios Médicos Ltda
      • Cali, Colombia
        • Fundación Reina Isabel
      • Cali, Colombia
        • IPS Centro Medico Julián Coronel S.A.
      • Espinal, Colombia
        • Fundación Centro de Investigaciones Biomédicas Riescard
      • Medellin, Colombia
        • Centro de Investigacion Clinica Avanzada
      • Medellin, Colombia, 50021
        • Fundacion Centro de Investigacion Clinica CIC, Medellin
      • Pasto, Colombia, 52002
        • Fundacion Centro de Obesidad y Metabolismo - COMETA
      • Zipaquirá, Colombia
        • Healthy Medical CenterS.A.S, Zipaquirá
  • Croatia
      • Karlovac, Croatia, 47000
        • General Hospital Karlovac
      • Krapinske Toplice, Croatia, 49217
        • Hospital for Medical Rehabilitation, Krapinske Toplice
      • Slavonski Brod, Croatia, 35000
        • General Hospital Slavonski Brod
      • Varazdin, Croatia, 42000
        • General Hospital Varazdin
      • Zadar, Croatia, 23000
        • General Hosp. Zadar, Dept. of Internal Medicine-Pulmonology
      • Zagreb, Croatia, 10000
        • University hospital center Zagreb
      • Zagreb, Croatia, 10000
        • Clinical Hospital Sveti Duh
  • Czechia
      • Brno, Czechia, 656 91
        • Fakultni nemocnice u sv. Anny v Brne
      • Brno, Czechia, 65691
        • Fakultni nemocnice u sv. Anny v Brne
      • Bruntal, Czechia, 792 01
        • Revmatologie Bruntal, S.R.O.
      • Chocen, Czechia, 56501
        • Poliklinika Chocen, a.s.
      • Dolni Brezany, Czechia, 252 41
        • Aesculap Ambulance Sro
      • Hodonin, Czechia, 695 01
        • OKELI s.r.o.
      • Jindrichuv Hradec, Czechia, 377 01
        • Nemocnice Jindrichuv Hradec a.s.
      • Liberec, Czechia, 460 63
        • Regional Hospital Liberec
      • Marianske Lazne, Czechia, 353 01
        • InterKardioML s.r.o.
      • Nachod, Czechia, 547 01
        • Interna a diabetologicka ordinace s.r.o.
      • Olomouc, Czechia, 77900
        • PreventaMed, s.r.o.
      • Praha 10, Czechia, 100 34
        • Univ. Hospital Kralovske Vinohrady
      • Praha 2, Czechia, 128 08
        • Vseobecna fakultni nemocnice v Praze
      • Praha 4 - Krc, Czechia, 140 59
        • Thomayer Hospital
      • Praha 8, Czechia, 181 00
        • ResTrial s.r.o.
      • Slany, Czechia, 274 01
        • Hospital Slany, Internal Department
      • Teplice, Czechia, 41501
        • Krajska zdravotni, a.s. - Nemocnice Teplice, o.z.
  • Germany
      • Aschaffenburg, Germany, 63739
        • Studienzentrum Aschaffenburg
      • Bad Homburg, Germany, 61348
        • Zentrum für klinische Forschung Dr. med. Irma Schöll & Kollegen
      • Dresden, Germany, 1307
        • Universitätsklinikum Carl Gustav Carus Dresden
      • Frankfurt, Germany, 60594
        • ClinPhenomics GmbH & Co KG, Frankfurt
      • Frankfurt am Main, Germany, 60596
        • IKF Pneumologie GmbH & Co. KG
      • Hohenmölsen, Germany, 6679
        • Diabetologische Schwerpunktpraxis, Hohenmölsen
      • Leipzig, Germany, 4103
        • EUGASTRO GmbH, Leipzig
      • Leipzig, Germany, 4249
        • Gemeinschaftspraxis Dr. Taeschner / Dr. Bonigut, Leipzig
  • Hungary
      • Baja, Hungary, 6500
        • Lausmed Kft. Outpatient Unit of Internal Medicine
      • Balassagyarmat, Hungary, 2660
        • Dr. Kenessey Albert Kórház-Rendelõintézet, Balassagyarmat
      • Balatonfured, Hungary, 8230
        • DRC Gyogyszervizsgalo Kozpont Kft., Balatonfured
      • Budapest, Hungary, 1033
        • ClinExpert Kft.
      • Budapest, Hungary, 1036
        • Óbudai Egészségügyi Centrum
      • Budapest, Hungary, 1036
        • Qualiclinic Kft
      • Budapest, Hungary, 1083
        • Semmelweis Egyetem, Budapest
      • Budapest, Hungary, 1088
        • Semmelweis Egyetem, Budapest
      • Budapest, Hungary, 1125
        • Semmelweis Egyetem, Budapest
      • Debrecen, Hungary, 4032
        • University Debrecen Hospital
      • Eger, Hungary, 3300
        • Markhot Ferenc Hospital, Eger
      • Hodmezovasarhely, Hungary, 6800
        • Csongrad Megyei Eu. Ellato Kozp. Hodmezovasarhely-Mako
      • Kaposvar, Hungary, 7400
        • Somogy Megyei Kaposi Mor Oktato Korhaz, Kaposvar
      • Komarom, Hungary, 2900
        • Selye Janos Hospital Komarom
      • Letavertes, Hungary, 4281
        • Ermellek Egeszsegcentrum
      • Miskolc, Hungary, 3526
        • Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz
      • Pecs, Hungary, 7624
        • Pécsi Tudományegyetem
      • Szeged, Hungary, 6725
        • Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klin. Kozpont
      • Zalaegerszeg, Hungary, 8900
        • Zala Megyei Szent Rafael Korhaz
  • Israel
      • Afula, Israel, 18101
        • Haemek Medical Center
      • Haifa, Israel, 3109601
        • Rambam Medical Center
      • Haifa, Israel, 31048
        • Bnei Zion Medical Center, Haifa
      • Herzliya, Israel, 4685107
        • Herzliya Medical Center
      • Holon, Israel, 58100
        • Wolfson Medical Center
      • Jerusalem, Israel, 9112001
        • Hadassah Medical Center, Ein-Karem
      • Kfar-Saba, Israel, 4428164
        • Meir Medical Center
      • Nahariya, Israel, 2210001
        • Galilee Medical Center
      • Safed, Israel, 13100
        • Ziv Medical Center
      • Tel Aviv, Israel, 6423906
        • Sourasky Medical Center
  • Japan
      • Aichi, Nagoya, Japan, 462-0825
        • Daishinkai Medical Corporation Ookuma Hospital
      • Chiba, Matsudo, Japan, 271-0077
        • Seikeikai New Tokyo Heart Clinic
      • Ehime, Matsuyama, Japan, 791-8026
        • Saiseikai Matsuyama Hospital
      • Fukuoka, Iizuka, Japan, 820-8505
        • Aso Co.,Ltd Iizuka Hospital
      • Fukuoka, Kitakyushu, Japan, 800-0295
        • Kitakyushubyoin Kitakyushu General Hospital
      • Hyogo, Kawanishi, Japan, 666-0125
        • The Veritas Hospital
      • Ibaraki, Sashima-gun, Japan, 306-0433
        • Ibaraki Seinan Medical Center Hospital
      • Kanagawa, Kawasaki, Japan, 210-0852
        • Kokan Clinic
      • Nagano, Nagano, Japan, 380-8582
        • Nagano Red Cross Hospital
      • Takamatsu-shi, Japan, 760-0076
        • Josuikai Olive Takamatsu Medical Clinic
  • Korea, Republic of
      • Anyang-si, Korea, Republic of, 431-070
        • Hallym University Sacred Heart Hospital
      • Busan, Korea, Republic of, 47392
        • Inje University Busan Paik Hospital
      • Busan, Korea, Republic of, 602-715
        • Dong-A University Hospital
      • Busan, Korea, Republic of, 602-739
        • Pusan National Univ. Hosp
      • Goyang-si, Korea, Republic of, 412-270
        • Myongji Hospital
      • Incheon, Korea, Republic of, 21565
        • Gachon University Gil Medical Center
      • Seoul, Korea, Republic of, 110744
        • Seoul National University Hospital
      • Seoul, Korea, Republic of, 138736
        • Asan Medical Center
      • Seoul, Korea, Republic of, 06591
        • The Catholic University of Korea, Seoul St.Mary's Hospital
      • Seoul, Korea, Republic of, 2841
        • Korea University Anam Hospital
      • Seoul, Korea, Republic of, 8308
        • Korea University Guro Hospital
      • Wonju, Korea, Republic of, 26426
        • Wonju Severance Christian Hosp
  • Malaysia
      • Alor Setar, Malaysia, 5460
        • Hospital Sultanah Bahiyah
      • Klang, Malaysia, 41200
        • Hospital Tengku Ampuan Rahimah
      • Kuala Lumpur, Malaysia, 59100
        • University Malaya Medical Centre
      • Kuantan, Malaysia, 25100
        • Hospital Tengku Ampuan Afzan
      • Petaling Jaya, Malaysia, 46150
        • Monash University(Sunway Campus)
      • Pulau Pinang, Malaysia, 10450
        • Hospital Pulau Pinang
      • Serdang, Malaysia, 43400
        • Universiti Putra Malaysia
      • Seri Manjung, Malaysia, 32040
        • Hospital Seri Manjung
      • Taiping, Malaysia, 34000
        • Hospital Taiping
      • Tampin, Malaysia, 73009
        • Klinik Kesihatan Tampin
  • Mexico
      • Chihuahua, Mexico, 31237
        • Investigacion En Salud Y Metabolismo S.C.
      • Cuautitlan Izcalli, Mexico, 54769
        • Phylasis Clinicas Research S de RL de CV
      • Culiacan, Mexico, CP80020
        • Centro para el Desarrollo de la Medicina y de Asist Med Espe
      • Distrito Federal, Mexico, 03100
        • Centro de Investigacion Biomedica y Farmaceutica, S.C.
      • Guadalajara, Mexico, 44690
        • Servicios Medicos de la Pena SC
      • Merida, Mexico, 97070
        • Medical Care & Research SA de CV
      • Merida, Mexico, 97129
        • Sociedad de Cirugia Vascular Plastica Reconstructiva
      • Mexico, Mexico, 06100
        • Comite Mexicano Para la Prevencion de Osteoporosis AC
      • Mexico, Mexico, 03100
        • Phytomedicamenta S.A. de C.V.
      • Mexico, Mexico, 06700
        • Centro de Atención e Investigación en Factores de Riesgo
      • Mexico, Mexico, 06700
        • Clinstile S.A. de C.V.
      • Mexico, Mexico, 11850
        • Ultimate Medica SA de CV
      • Mexico, Mexico, 3810
        • Health Pharma Professional Research S.A. de C.V.
      • Monterrey, Mexico, 64710
        • AVIX Investigación Clínica S.C
      • Monterrey, Mexico, 64620
        • Centro de Estudios Clinicos y Especialidades Medicas, S.C.
      • Monterrey, Mexico, 64718
        • Global Trial Research Center S.A. de C.V.
      • Morelia, Mexico, 58260
        • Centro de Investigacion Clinica Chapultepec S. A. de C. V.
      • Queretaro, Mexico, 76000
        • Centro de Estudios Clínicos de Queretaro S.C., CECLIQ
      • Tijuana, Mexico, 22500
        • Centro de Investigacion Cardiovascular y Metabolica
      • Zapopan, Mexico, 45116
        • Centro de Investigación Médica de Ocidente, S.C.
      • Zapopan, Mexico, 45200
        • Hospital Dr Angel Leano
  • Netherlands
      • Arnhem, Netherlands, 6815 AD
        • Rijnstate Hospital
      • Dordrecht, Netherlands, 3318 AT
        • Albert SchweitzerZiekenhuis
      • Groningen, Netherlands, 9713 GZ
        • Universitair Medisch Centrum Groningen
      • Groningen, Netherlands, 9728 NT
        • Martini Ziekenhuis
      • Hoogeveen, Netherlands, 7909 AA
        • Bethesda Cardiology Group, Hoogeveen
      • Maastricht, Netherlands, 6229 HX
        • Maastricht Universitair Medisch Centrum
      • Rotterdam, Netherlands, 3039 BD
        • Rotterdam Research Institute
      • Utrecht, Netherlands, 3584 CX
        • Universitair Medisch Centrum Utrecht
      • Waalwijk, Netherlands, 5141 BM
        • TweeSteden Ziekenhuis
      • Zutphen, Netherlands, 7207 BA
        • Gelre Ziekenhuis Zutphen
  • Poland
      • Chorzow, Poland, 41-500
        • B_Serwis Popenda Sp.Jawna
      • Gdansk, Poland, 80-952
        • University Clinical Center, Gdansk
      • Gdansk, Poland, 80-286
        • Poradnia Kardiologiczna Jaroslaw Jurowiecki
      • Gdynia, Poland, 81-157
        • Indywidualna Specjalistyczna Praktyka Lekarska
      • Grodzisk Mazowiecki, Poland, 05-825
        • MCBK Iwona Czajkowska Anna Podrażka- Szczepaniak S.C.
      • Katowice, Poland, 40-084
        • Centrum Medyczne Pratia Katowice II
      • Kielce, Poland, 25-364
        • Polimedica Centrum Bada?, Profilaktyki I Leczenia
      • Krakow, Poland, 31-637
        • NZOZ Centrum Medyczne ProMiMed Sp. z o.o., Sp.k., Krakow
      • Lodz, Poland, 94-255
        • Individual Specialized Practice
      • Lodz, Poland, 90-242
        • Centrum Terapii Wspolczesnej J.M.
      • Lodz, Poland, 90-368
        • CCBR - Lodz - PL, Lodz
      • Lublin, Poland, 20-362
        • KO-MED Centra Kliniczne Lublin II
      • Lublin, Poland, 20-538
        • NZOZ Specialized Ambulance "MEDICA"
      • Lublin, Poland, 20-109
        • Centrum Medyczne "Luxmed" Sp. z o.o.
      • Nowy Duninow, Poland, 09-505
        • RCMed- Regionalne Centrum Medyczne
      • Oswiecim, Poland, 32-600
        • Medicome Sp. z o.o.
      • Parczew, Poland, 21-200
        • Prywatny Gabinet Lekarski Lech Lazuka
      • Poznan, Poland, 61-655
        • Praktyka Lekarska Ewa Krzyzagorska
      • Poznan, Poland, 60-569
        • Clin.Hosp.Med.Univ.Marcinkowski in Poznan
      • Pulawy, Poland, 24-100
        • KOMED Marek Konieczny
      • Ruda Slaska, Poland, 41-709
        • Indywidualna Specjalistyczna Praktyka Lekarska Dr N Med Andrzej Wittek
      • Rzeszow, Poland, 35-055
        • Centrum Medyczne Medyk
      • Sochaczew, Poland, 96-500
        • RCMed- Regionalne Centrum Medyczne
      • Sroda Wielkopolska, Poland, 63-000
        • NSZOZ Medicus
      • Staszow, Poland, 28-200
        • KO-MED Centra Kliniczne Staszow
      • Torun, Poland, 87-100
        • NZOZ Nasz Lekarz
      • Torun, Poland, 87-100
        • Lecznice Citomed Sp. z o.o.
      • Warsaw, Poland, 00-465
        • Nbr Polska
      • Warszaw, Poland, 04-730
        • CCBR/Somed - Warszaw - PL
      • Wroclaw, Poland, 50-127
        • Regionalna Poradnia Diabetoloiczna Zytkiewicz-Jaruga
      • Zamosc, Poland, 22-400
        • KO-MED Centra Kliniczne Zamosc
      • Zgierz, Poland, 95-100
        • Polimedica Centrum Bada?, Profilaktyki I Leczenia
  • Portugal
      • Braga, Portugal, 4710-243
        • Hospital de Braga-Escala Braga
      • Coimbra, Portugal, 3000-075
        • CHUC - Centro Hospitalar e Universitário de Coimbra, EPE
      • Lisboa, Portugal, 1500-650
        • Hospital da Luz
      • Lisboa, Portugal, 1449-005
        • CHLO, EPE - Hospital S. Francisco Xavier
      • Lisboa, Portugal, 1250-203
        • APDP - Associação Protectora dos Diabéticos de Portugal
      • Porto, Portugal, 4100-180
        • Hospital CUF Porto
      • V. N. Gaia, Portugal, 4434-502
        • Centro Hospitalar de Vila Nova de Gaia
  • Romania
      • Alba Iulia, Romania, 510053
        • SC Diana Barbonta SRL, Alba Iulia
      • Bucuresti, Romania, 10192
        • Clinica Medicala Data Plus SRL
      • Bucuresti, Romania, 010825
        • Spitalul Universitar de Urgenta, Bucuresti
      • Bucuresti, Romania, 011234
        • I.N.D.N.B.M. "Prof. Dr. N.C. Paulescu" - Sediul Central
      • Bucuresti, Romania, 020475
        • I.N.D.N.B.M. "Prof. Dr. N.C. Paulescu" - Sediul Central
      • Bucuresti, Romania, 061072
        • CMI Dr. Stolea T. Violeta
      • Bucuresti, Romania, 20045
        • I.N.D.N.B.M. "Prof. Dr. N.C. Paulescu" - Sediul "I.L. Caragiale"
      • Bucuresti, Romania, 20614
        • S.C Centrul Medical "Sanatatea Ta" S.R.L
      • Bucuresti, Romania, 30463
        • S.C. Policlinica CCBR SRL, Bucuresti
      • Buzau, Romania, 120203
        • Medcon SRL
      • Galati, Romania, 800578
        • Spitalul Clinic Judetean de Urgenta ¿Sf. Apostol Andrei¿
      • Iasi, Romania, 700547
        • Consultmed SRL, Iasi
      • Iasi, Romania, 700503
        • Spitalul Clinic, Iasi
      • Iasi, Romania, 700613
        • SC Diaconu-Sotropa Michaela, Cabinet de Diabet
      • Oradea, Romania, 410469
        • Pelican Impex SRL, Cabinet Nr. 15
      • Oradea, Romania, 410159
        • S.C Grandmed S.R.L, Oradea
      • Oradea, Romania, 410491
        • S.C Anamed S.R.L
      • Ploiesti, Romania, 100163
        • S.C. Diabmed Dr. Popescu Alexandrina S.R.L
      • Sibiu, Romania, 550371
        • Gensan SRL
      • Timisoara, Romania, 300456
        • Centrul Medical Dr Negrisanu SRL
      • Tirgu Mures, Romania, 540142
        • Mediab SRL
  • Russian Federation
      • Barnaul, Russian Federation, 656038
        • SBEI HPE Altay State Medical University of MoH and SD
      • Kemerovo, Russian Federation, 650002
        • Res.Inst.-Compl.Iss.Cardi.Dis.
      • Kemerovo, Russian Federation, 650055
        • NSIH "Departmental Hospital on Station Kemerovo of OJSC "Russian Railways"
      • Moscow, Russian Federation, 119992
        • Moscow 1st State Med.Univ.n.a.I.M.Sechenov
      • Moscow, Russian Federation, 119435
        • First Moscow State Medical University n.a. I.M. Sechenov
      • Moscow, Russian Federation, 127473
        • SBEI HPE "Moscow State Medical and Dentistry University
      • Moscow, Russian Federation, 129301
        • Moscow State Medical Dentistry University
      • Novosibirsk, Russian Federation, 630008
        • SBIH of Novosibirsk Region "Clinical Emergency Hospital #2"
      • Novosibirsk, Russian Federation, 630117
        • FSBSI "Scientific and Research Institute of Physiology and Basic Medicine"
      • Novosibirsk, Russian Federation, 630047
        • Novosibirsk Regional Clinical Cardiological Dispansary
      • Novosibirsk, Russian Federation, 630089
        • FSBSI "Scientific Research Institute", Novosibirsk
      • Omsk, Russian Federation, 644021
        • BIH of OR "City Hospital # 2", Omsk
      • Perm, Russian Federation, 614068
        • SBIH of Perm territory " City Clinical Hospital # 2 n.a.
      • Ryazan, Russian Federation, 390026
        • SBI of Ryazan region "Regional Clinical Cardiological Dis.
      • Saint-Petersburg, Russian Federation, 197022
        • 1stPavlov St.Med.Univ.St.-Petersburg Res.Inst.
      • Saint-Petersburg, Russian Federation, 197341
        • Federal North-West Medical Research Centre
      • Saint-Petersburg, Russian Federation, 199106
        • SPb SBIH "City Pokrovskaya Hospital"
      • Saint-Petersburg, Russian Federation, 194044
        • FSBMEI HPE "Military Medical Academy n.a. S.M. Kirov"
      • Saint-Petersburg, Russian Federation, 197762
        • SPb SBHI "City Policlinic #74"
      • Sestroretsk, Russian Federation, 197706
        • GUZ "City Clinical Hospital #40, 197706 Saint-Petersburg
      • St. Petersburg, Russian Federation, 196084
        • Medical Research Institute LLC, St. Petersburg
      • Tomsk, Russian Federation, 634012
        • FSBI "Research Institute for Cardiology"
  • South Africa
      • Alberton, South Africa, 1449
        • Cardiology Clinical Research
      • Bloemfontein, South Africa, 9301
        • Iatros International
      • Bloemfontein, South Africa, 9301
        • Limaro Research
      • Cape Town, South Africa, 7925
        • Groote Schuur Hospital
      • Cape Town, South Africa, 7500
        • TREAD Research
      • Cape Town, South Africa, 7570
        • Langeberg Clinical Trials
      • Cape Town, South Africa, 7129
        • Dr JM Engelbrecht Practice
      • Cape Town, South Africa, 7405
        • Dr Dawood, Mohamed and Pillay
      • Cape Town, South Africa, 7580
        • Cape Town Medical Research Centre
      • Cape Town, South Africa, 7764
        • Ismail, SM
      • Durban, South Africa, 4001
        • Latiff, GHVM
      • Durban, South Africa, 4001
        • Londisizwe Research Centre, Durban
      • Johannesburg, South Africa, 2193
        • WCR CMJAH Clinical Trial Site
      • Johannesburg, South Africa, 1501
        • Diabetes Care Centre
      • Johannesburg, South Africa, 2013
        • Wits Clinical Research Chris Hani Baragwanath Hospital
      • Krugersdorp, South Africa, 1739
        • DJW Navorsing
      • Pretoria, South Africa, 0002
        • University of Pretoria
      • Pretoria, South Africa, 0002
        • Emmed Research
      • Pretoria, South Africa, 181
        • Into Research
      • Pretoria, South Africa, 0087
        • Syzygy Clinical Research Services
      • Pretoria, South Africa, 2
        • Seeber, M
      • Verulam, South Africa, 4339
        • Dr M Duki Research and Trial Site, Verulam
      • Worcester, South Africa, 6850
        • Clinical Projects Research
  • Spain
      • Almeria, Spain, 04120
        • Hospital Virgen del Mar
      • Alzira, Spain, 46600
        • Hospital de la Ribera
      • Badalona, Spain, 08916
        • Hospital Germans Trias i Pujol
      • Barcelona, Spain, 08023
        • Hospital Quiron. I.C.U.
      • Barcelona, Spain, 08006
        • specialist
      • Barcelona, Spain, 08017
        • CAP Sarrià
      • Centelles, Spain, 08540
        • EBA Centelles
      • Madrid, Spain, 28040
        • Fundacion Jimenez Diaz
      • Malaga, Spain, 29010
        • Hospital Regional Universitario de Málaga
      • Segovia, Spain, 40002
        • Hospital General de Segovia
      • Sevilla, Spain, 41071
        • Hospital Virgen Macarena
      • Sevilla, Spain, 41010
        • Hospital Quironsalud Infanta Luisa
      • Valencia, Spain, 46014
        • Hospital General Universitario de Valencia
      • Valencia, Spain, 46017
        • Hospital Dr. Peset
      • Villamartin, Spain, 11650
        • Hospital Virgen de las Montañas, Villamartin
  • Taiwan
      • Kaohsiung, Taiwan, 81362
        • Kaohsiung Veterans General Hospital
      • Kaohsiung, Taiwan, 807
        • Kaohsiung Medical University Chung-Ho Memorial Hospital
      • New Taipei City, Taiwan, 220
        • Far Eastern Memorial Hospital
      • Taichung, Taiwan, 404
        • China Medical University Hospital
      • Tainan, Taiwan, 704
        • NCKUH
      • Taipei, Taiwan, 100
        • National Taiwan University Hospital
      • Taipei, Taiwan, 11217
        • Taipe Veterans General Hospital
      • Taoyuan County, Taiwan, 333
        • Chang-Gung Memorial Hospital, Linkou
  • Ukraine
      • Chernivtsi, Ukraine, 58022
        • Chernivtsi Regional Endocrinology Dispensary
      • Ivano-Frankivsk, Ukraine, 76008
        • Regional CH Dept of Endocrinology SHEI Ivano-Frankivsk NMU
      • Ivano-Frankivsk, Ukraine, 76018
        • CI Ivano-Frankivsk Reg Cl Card Center
      • Kharkiv, Ukraine, 61039
        • L.T. Malaya Institute of Therapy AMS of Ukraine
      • Kharkiv, Ukraine, 61176
        • CI of Healthcare Kharkiv CCH #8, Kharkiv
      • Kharkiv, Ukraine, 61103
        • CIPH Prof. O.I. Meshchaninov Kharkiv CCH of A&E
      • Kyiv, Ukraine, 1601
        • Kjiv City Oleksandrivska Clinical Hospital
      • Kyiv, Ukraine, 01004
        • KCCC of Endocr Dept of General Endocrine Pathology
      • Kyiv, Ukraine, 02091
        • City Clinical Hospital No. 1, Kiev
      • Kyiv, Ukraine, 04114
        • V.P. Komisarenko Inst. of Endocrinology and Metabolism
      • Kyiv, Ukraine, 2002
        • LLC Treatment and Diagnostic Center Adonis Plus, Kyiv
      • Kyiv, Ukraine, 3115
        • SI National Scientific Centre of Radiation Medicine of NAMSU
      • Kyiv, Ukraine, 4050
        • P.L. Shupyk NMA of PGE Ch of D H for S-ts of NASU
      • Kyiv, Ukraine, 4114
        • SI V.P.Komisarenko Institute of Endocrinology and Metabolism
      • Lviv, Ukraine, 79010
        • Lviv Regional Endocrinology Dispensary
      • Poltava, Ukraine, 36011
        • M.V. Sklifosovskyi Poltava RCH, Poltava
      • Sumy, Ukraine, 40021
        • CI Sumy City Clinical Hospital #1 Dept of Therapy Sumy SU
      • Ternopli, Ukraine, 46002
        • CI of TRC Ternopil UH
      • Vinnytsia, Ukraine, 21018
        • M.I. Pyrogov VRCH, Vinnytsia
      • Vinnytsia, Ukraine, 21001
        • Private Small Enterprise Medical Center Pulse
      • Vinnytsia, Ukraine, 21010
        • Vinnytsia RC Highly Special.Endocr.Center Dept of Therapy
      • Vinnytsia, Ukraine, 21021
        • CCH #1 M.I. Pyrogov VNMU Ch of Propaedeutics of IM
      • Zaporizhzhia, Ukraine, 69001
        • CI Zapor CCH#10 SI ZMA PGE Ch of therapy clin pharmacol & endocrin
  • United Kingdom
      • Airdrie, United Kingdom, ML6 0JS
        • University Hospital Monklands
      • Birmingham, United Kingdom, B15 2TH
        • Queen Elizabeth Hospital
      • Bradford on Avon, United Kingdom, BA15 1DQ
        • Bradford on Avon Health Centre
      • Chesterfield, United Kingdom, S40 4AA
        • Ashgate Medical Practice
      • Dumfries, United Kingdom, DG1 4AP
        • Dumfries and Galloway Royal Infirmary
      • Dundee, United Kingdom, DD1 9SY
        • Ninewells Hospital & Medical School
      • Exeter, United Kingdom, EX2 5DW
        • Royal Devon and Exeter Hospital
      • Glasgow, United Kingdom, G4 0SF
        • Glasgow Royal Infirmary
      • Leicester, United Kingdom, LE5 4PW
        • Leicester General Hospital
      • London, United Kingdom, EC1M 6BQ
        • Barts and The London School of Medicine and Dentistry
      • Swansea, United Kingdom, SA6 6NL
        • Morriston Hospital
      • Welwyn Garden City, United Kingdom, AL7 4HQ
        • Queen Elizabeth II Hospital
      • Wolverhampton, United Kingdom, WV10 0QP
        • New Cross Hospital
  • United States
    • Alabama
      • Huntsville, Alabama, United States, 35801
        • Longwood Research
      • Scottsboro, Alabama, United States, 35768
        • Scottsboro Quick Care Clinic
      • Tuscumbia, Alabama, United States, 35674
        • Office of Dr. Terence T. Hart MD
    • Arizona
      • Glendale, Arizona, United States, 85306
        • Arrowhead Health Centers
      • Phoenix, Arizona, United States, 85032
        • Precision Trials, LLC
    • Arkansas
      • Harrisburg, Arkansas, United States, 72432
        • Harrisburg Family Medical Center
      • Little Rock, Arkansas, United States, 72205
        • Little Rock Diagnostic Clinic
      • Little Rock, Arkansas, United States, 72204
        • Cardiology and Medicine Clinic
    • California
      • Bonita, California, United States, 91902
        • Kaiser Permanente - San Diego, Bonita
      • Concord, California, United States, 94520
        • John Muir Physician Network Clinical Research Center
      • Fresno, California, United States, 93720
        • Valley Research
      • Loma Linda, California, United States, 92357
        • VA Loma Linda Healthcare System
      • Long Beach, California, United States, 90807
        • Long Beach Center For Clinical Research
      • Los Angeles, California, United States, 90057
        • National Research Institute
      • Los Angeles, California, United States, 90019
        • Clearview Medical Research, LLC
      • Los Gatos, California, United States, 95032
        • Office of Dr. Richard S. Cherlin
      • Los Osos, California, United States, 93402
        • Coastal Medical Research Group
      • Modesto, California, United States, 95350
        • Novo Research, Incorporated
      • North Hollywood, California, United States, 91606
        • Providence Clinical Research
      • Northridge, California, United States, 91324
        • Northridge Clinical Research Inc.
      • Oceanside, California, United States, 92056
        • Carr Cardiology
      • Sacramento, California, United States, 95823
        • Center for Clinical Trials of Sacramento, Incorporated
      • San Dimas, California, United States, 91773
        • North America Research Institute
      • San Jose, California, United States, 95116
        • Trinitas Research, Incorporated
      • Tarzana, California, United States, 91356
        • Metabolic Institute of America
      • West Covina, California, United States, 91790
        • Center for Clinical Trials of San Gabriel
    • Colorado
      • Arvada, Colorado, United States, 80002
        • Western Nephrology & Metabolic
      • Denver, Colorado, United States, 80210
        • South Denver Nephrology
      • Golden, Colorado, United States, 80401
        • Colorado Center for Bone Research, P.C.
    • Florida
      • Boynton Beach, Florida, United States, 33437
        • Orthopedic Research Institute
      • Boynton Beach, Florida, United States, 33435
        • Helix Biomedics LLC
      • Bradenton, Florida, United States, 34209
        • Nova Clinical Research, LLC
      • Brandon, Florida, United States, 33511
        • PAB Clinical Research
      • Brooksville, Florida, United States, 34601
        • Meridien Research
      • Chiefland, Florida, United States, 32626
        • Southeast Clinical Research, LLC
      • Clearwater, Florida, United States, 33756
        • BayCare Medical Group
      • Delray Beach, Florida, United States, 33446
        • Cohen Medical Research Associates, LLC
      • Doral, Florida, United States, 33166
        • Innovation Medical Research Center, Inc
      • Fort Lauderdale, Florida, United States, 33312
        • Integrative Research Associates
      • Fort Lauderdale, Florida, United States, 33312
        • Jellinger and Lerman, MD, PA dba The Center for Diabetes and Endocrine Care
      • Hialeah, Florida, United States, 33012
        • Universal Clinical Research
      • Hialeah, Florida, United States, 33012
        • Direct Helpers Medical Center, Inc
      • Homestead, Florida, United States, 33032
        • Homestead Associates in Research
      • Jacksonville, Florida, United States, 32216
        • St. Vincent's Cardiology
      • Jacksonville, Florida, United States, 32277
        • Care Partners Clinical Research LLC
      • Lake Clarke Shores, Florida, United States, 33406
        • Altus Research, Inc.
      • Lakeland, Florida, United States, 33805
        • Meridien Research
      • Miami, Florida, United States, 33136
        • University of Miami
      • Miami, Florida, United States, 33155
        • Regenerate Clinical Trials
      • Miami, Florida, United States, 33175
        • New Horizon Research Center
      • Miami, Florida, United States, 33165
        • Future Care Solution, LLC
      • Miami, Florida, United States, 33186
        • Coral Research Clinic Corp
      • Miami, Florida, United States, 33155
        • Sanitas Research
      • Miami, Florida, United States, 33142
        • Florida Medical Center & Research Inc
      • Miami, Florida, United States, 33133
        • Prestige Clinical Research Center, Inc.
      • Miami, Florida, United States, 33173
        • Research Institute of South Florida Inc
      • Miami, Florida, United States, 33185
        • Kendall South Medical Center, Inc
      • Miami, Florida, United States, 33126
        • Clinical Research of Miami
      • Miami, Florida, United States, 33134
        • Jesscan Medical Research, Internal Medicine
      • Miami, Florida, United States, 33135
        • Clintex Research Group, Inc. Research
      • Miami, Florida, United States, 33144
        • A+ Research Incorporated
      • Miami, Florida, United States, 33144
        • Unlimited Medical Research, LLC
      • Miami, Florida, United States, 33173
        • Tellus Clinical Research, Incorporated
      • Miami Lakes, Florida, United States, 33016
        • Precision Research Organization
      • North Miami Beach, Florida, United States, 33162
        • Harmony Clinical Research, Incorporated
      • North Miami Beach, Florida, United States, 33144
        • School of Clinical Research
      • Ocala, Florida, United States, 34471
        • Magnolia Research Group
      • Orlando, Florida, United States, 32806
        • Family Medical Center
      • Ormond Beach, Florida, United States, 32174
        • Peninsula Research, Inc.
      • Plantation, Florida, United States, 33317
        • Infinity Clinical Research, LLC
      • Saint Petersburg, Florida, United States, 33709
        • Meridien Research
      • Saint Petersburg, Florida, United States, 33713
        • Professional Health Care of Pinellas, Inc.
      • Sarasota, Florida, United States, 34232
        • Intercoastal Medical Group, Endocrinology
      • Tampa, Florida, United States, 33634
        • Meridien Research
      • West Palm Beach, Florida, United States, 33401
        • Metabolic Research Institute
    • Georgia
      • Atlanta, Georgia, United States, 30303
        • Emory University
      • Atlanta, Georgia, United States, 30308
        • Laureate Clinical Research Group, LLC
      • Bainbridge, Georgia, United States, 39819
        • Bainbridge Medical Associates
      • Cumming, Georgia, United States, 30041
        • Atlanta Heart Specialists, LLC
      • Decatur, Georgia, United States, 30035-4000
        • McGarity, Jr., William C.
      • Tucker, Georgia, United States, 30084
        • Atlanta Heart Specialists, LLC
    • Illinois
      • Belleville, Illinois, United States, 62220
        • Belleville Family Medical Associates, Ltd
      • Chicago, Illinois, United States, 60607
        • Cedar-Crosse Research Center
      • Chicago, Illinois, United States, 60607
        • Chicago Clinical Research Institute, Inc.
      • Elgin, Illinois, United States, 60124
        • Associates in Endocrinology, Incorporated
      • Joliet, Illinois, United States, 60435
        • Kidney Care Center, Nephrology
    • Indiana
      • Avon, Indiana, United States, 46123
        • American Health Network
      • Franklin, Indiana, United States, 46131
        • American Health Network of Indiana, LLC
      • Greenfield, Indiana, United States, 46140
        • American Health Network of Indiana, LLC
      • Muncie, Indiana, United States, 47304
        • American Health Network of Indiana, LLC
      • Valparaiso, Indiana, United States, 46383
        • Buynak Clinical Research
    • Iowa
      • Waterloo, Iowa, United States, 50702
        • Northeast Iowa Medical Education Foundation
      • West Des Moines, Iowa, United States, 50265
        • Iowa Diabetes and Endocrinology Research Center
    • Kansas
      • Topeka, Kansas, United States, 66606
        • Cotton-O'Neil Clinical Research Center
      • Wichita, Kansas, United States, 67203
        • Professional Research Network of Kansas, LLC
      • Wichita, Kansas, United States, 67205
        • Heartland Research Associates, LLC
    • Kentucky
      • Lexington, Kentucky, United States, 40503
        • The Research Group of Lexington, LLC
    • Louisiana
      • Metairie, Louisiana, United States, 70006
        • Diabetes and Metabolism Associates APMC
      • New Orleans, Louisiana, United States, 70112
        • Tulane University Hospital and Clinic
    • Maryland
      • Baltimore, Maryland, United States, 21287
        • Johns Hopkins University
      • Baltimore, Maryland, United States, 21229
        • Maryland Cardiovascular Specialists
      • Baltimore, Maryland, United States, 21236
        • Overlea Personal Physicians
      • Salisbury, Maryland, United States, 21804
        • Delmarva Heart Research Foundation, Inc
    • Michigan
      • Alpena, Michigan, United States, 49707
        • Endeavor Medical Research
      • Ann Arbor, Michigan, United States, 48105
        • University of Michigan Health System
      • Flint, Michigan, United States, 48504
        • Aa Mrc Llc
      • Petoskey, Michigan, United States, 49770
        • McLaren Northern Michigan Hospital
      • Rochester, Michigan, United States, 48307
        • Remedica LLC
      • Sterling Heights, Michigan, United States, 48310-3503
        • Tri-County Research, Inc
      • Troy, Michigan, United States, 48085
        • Oakland Medical Research Center
    • Minnesota
      • Saint Paul, Minnesota, United States, 55102
        • HealthEast St. Joseph's Hospital
    • Mississippi
      • Carriere, Mississippi, United States, 39426
        • Mississippi Medical Research, LLC
    • Missouri
      • Kansas City, Missouri, United States, 64128
        • Kansas City Veterans Administration Medical Center
      • Kansas City, Missouri, United States, 64108
        • Truman Medical Centers, Inc.
    • Montana
      • Kalispell, Montana, United States, 59901
        • Glacier View Cardiology, PC
    • Nebraska
      • North Platte, Nebraska, United States, 69101
        • Platte River Nephrology
      • Omaha, Nebraska, United States, 68131
        • Omaha Veterans Affairs Medical Center
    • Nevada
      • Las Vegas, Nevada, United States, 89120
        • ALAS Science Clinical Research
    • New Jersey
      • Elizabeth, New Jersey, United States, 07201
        • USMA Clin. Research/Union Square Med. Associates
      • Linden, New Jersey, United States, 07036
        • Mount Sinai - PRIME
    • New Mexico
      • Albuquerque, New Mexico, United States, 87106
        • New Mexico Clinical Research and Osteoporosis Center, Inc.
    • New York
      • Bronx, New York, United States, 10461
        • Jacobi Medical Center
      • Brooklyn, New York, United States, 11206
        • Life Medi-research and Management
      • Johnson City, New York, United States, 13901
        • United Medical Associates
      • Saratoga Springs, New York, United States, 12866
        • Saratoga Clinical Research, LLC
    • North Carolina
      • Burlington, North Carolina, United States, 27215
        • Kernodle Clinic West
      • Calabash, North Carolina, United States, 28467
        • Main Street Physicians Care
      • Charlotte, North Carolina, United States, 28210
        • Box Arthritis & Rheumatology of the Carolinas
      • Gastonia, North Carolina, United States, 28054
        • Clinical Research of Gastonia
      • Greensboro, North Carolina, United States, 27408
        • Medication Management, LLC
      • Hickory, North Carolina, United States, 28601
        • PMG Research of Bristol, LLC
      • Monroe, North Carolina, United States, 28110
        • Novant Health Southern Piedmont Primary Care
      • Mooresville, North Carolina, United States, 28117
        • Research Institute of the Carolinas, PLC
      • Morehead City, North Carolina, United States, 28557
        • Down East Medical Associates
      • Morganton, North Carolina, United States, 28655
        • Burke Primary Care
      • Salisbury, North Carolina, United States, 28144
        • PMG Research of Salisbury, LLC
      • Wilson, North Carolina, United States, 27893
        • Natalie A Doyle, M.D., P.A.
    • Ohio
      • Akron, Ohio, United States, 44304
        • Summa Health System
      • Carlisle, Ohio, United States, 45005
        • Medical Frontiers, LLC
      • Dayton, Ohio, United States, 45428
        • Dayton VA Medical Center
      • Norton, Ohio, United States, 44203
        • Norton Community Care
      • Springfield, Ohio, United States, 45505
        • Apex Medical Research, AMR, Incorporated
      • Toledo, Ohio, United States, 43606
        • ProMedica Health Education & Research Corp.
    • Oklahoma
      • Oklahoma City, Oklahoma, United States, 73112
        • Lynn Health Science Institute
      • Oklahoma City, Oklahoma, United States, 73103
        • COR Clinical Research, LLC
    • Oregon
      • Corvallis, Oregon, United States, 97330
        • The Corvallis Clinic, PC
    • Pennsylvania
      • Altoona, Pennsylvania, United States, 16602
        • Clinical Research Associates of Central Pennsylvania
      • Altoona, Pennsylvania, United States, 16602
        • Blair Medical Associates
      • Doylestown, Pennsylvania, United States, 18901
        • Central Bucks Cardiology
      • Doylestown, Pennsylvania, United States, 18901
        • Doylestown Health Cardiology
      • Jersey Shore, Pennsylvania, United States, 17740
        • Lycoming Internal Medicine, Inc
      • Smithfield, Pennsylvania, United States, 15478
        • Montgomery Medical Incorporated
    • South Carolina
      • Charleston, South Carolina, United States, 29425
        • Medical University of South Carolina
      • Charleston, South Carolina, United States, 29406
        • Clinical Trials of South Carolina
      • Gaffney, South Carolina, United States, 29341
        • Spectrum Medical Research, LLC
      • Greenville, South Carolina, United States, 29615
        • VitaLink Research
      • Greer, South Carolina, United States, 29651
        • Mountain View Clinical Research
      • Rock Hill, South Carolina, United States, 29732
        • Vita Link Research- Rock Hill
    • South Dakota
      • Rapid City, South Dakota, United States, 57702
        • Health Concepts
    • Tennessee
      • Bristol, Tennessee, United States, 37620
        • Holston Medical Group
      • Johnson City, Tennessee, United States, 37604
        • State of Franklin Healthcare Associates, PLLC
    • Texas
      • Austin, Texas, United States, 78758
        • DCT- AACT, LLC dba Discovery Clinical Trials
      • Bedford, Texas, United States, 76022
        • Rockwood Medical Clinic
      • Dallas, Texas, United States, 75231
        • Research Institute Of Dallas
      • Dallas, Texas, United States, 75218
        • Texas Health Physicians Group
      • Houston, Texas, United States, 77030
        • Ben Taub General Hospital
      • Houston, Texas, United States, 77074
        • Southwest Clinical Trials
      • Houston, Texas, United States, 77079
        • The Endocrine Center
      • Houston, Texas, United States, 77082
        • Texas Family Geriatrics Clinic
      • Houston, Texas, United States, 77084
        • Memorial Clinical Associates Research
      • Irving, Texas, United States, 75039
        • Break Through Medical Research
      • Irving, Texas, United States, 75061
        • Medical & Surgical Clinic
      • Katy, Texas, United States, 77450
        • West Memorial Family Practice
      • New Braunfels, Texas, United States, 78130
        • Hill Country Medical Associates
      • Odessa, Texas, United States, 79761
        • Permian Research Foundation
      • Pearland, Texas, United States, 77584
        • Methodist Hospital Research Institute, Internal Medicine
      • San Antonio, Texas, United States, 78258
        • DCT-Stone Oak, LLC dba Discovery Clinical Trials
      • San Antonio, Texas, United States, 78229
        • Covenant Clinical Research, Pa
      • San Antonio, Texas, United States, 78249
        • DM Clinical Research
      • San Antonio, Texas, United States, 78228-6205
        • Health Texas Research Institute
      • Sealy, Texas, United States, 77474
        • Sealy Urgent Care Center and Medical Clinic
      • Sugar Land, Texas, United States, 77479
        • Pioneer Research Solutions, Inc.
      • Tomball, Texas, United States, 77375
        • DM Clinical Research
      • Victoria, Texas, United States, 77901
        • Crossroads Clinical Research, LLC
    • Utah
      • Clinton, Utah, United States, 84015
        • Ericksen Research & Development, LLC
      • Draper, Utah, United States, 84020
        • Focus Clinical Research
      • Ogden, Utah, United States, 84405
        • Advanced Research Institute
      • Ogden, Utah, United States, 84405
        • Paramount Medical Care
    • Virginia
      • Burke, Virginia, United States, 22015
        • Burke Internal Medicine and Research
      • Herndon, Virginia, United States, 20170
        • Nova Health Management & Research Group, PC
      • Manassas, Virginia, United States, 20110
        • Manassas Clinical Research Center
      • Richmond, Virginia, United States, 23249
        • Hunter Holmes McGuire Veterans Administration Medical Center
      • Richmond, Virginia, United States, 23219
        • Dominion Medical Associates, Inc.
      • Roanoke, Virginia, United States, 24014
        • Roanoke Heart Institute PLC
      • Salem, Virginia, United States, 24153
        • Salem Veterans Affairs Medical Center
    • Washington
      • Port Orchard, Washington, United States, 98366
        • Sound Medical Research
    • Wisconsin
      • Milwaukee, Wisconsin, United States, 53295
        • Zablocki VA Medical Center

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (ADULT, OLDER_ADULT)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion criteria:

  1. Documented diagnosis of T2DM before visit 1(screening).
  2. Male or female patients who are drug-naïve or pre-treated with any antidiabetic background medication, excluding treatment with Glucagon-like Peptide 1 (GLP-1) receptor agonists, Dipeptidyl-peptidase 4 (DPP-4) inhibitors or Sodium Glucose Linked Transporter 2 (SGLT-2) inhibitors if => consecutive 7 days.
  3. Stable antidiabetic background medication (unchanged daily dose) for at least 8 weeks prior to randomization. If insulin is part of the background therapy, the average daily insulin dose should not have changed by more than 10% within the 8 weeks prior to randomization compared with the daily insulin dose at randomization.
  4. HbA1c of => 6.5% and <= 10.0% at Visit 1 (screening)
  5. Age => 18 years at Visit 1(screening). For Japan only: Age => 20 years at Visit 1
  6. Body Mass Index (BMI) <= 45 kg/m2 at Visit 1 (screening)
  7. Signed and dated written informed consent by date of Visit 1(screening) in accordance with Good Clinical Practice (GCP) and local legislation prior to any study related procedure
  8. High risk of cardiovascular (CV) events defined by: 1) albuminuria (micro or macro) and previous macrovascular disease and/or 2) impaired renal function with predefined Urine Albumin Creatinine Ratio (UACR)

Exclusion criteria:

  1. Type 1 diabetes mellitus.
  2. Treatment (=> 7 consecutive days) with GLP-1 receptor agonists, other DPP-4 inhibitors or SGLT-2 inhibitors prior to informed consent. Note: This also includes clinical trials where these antidiabetic drugs have been provided to the patient.
  3. Active liver disease or impaired hepatic function, defined by serum levels of either Alanine Transaminase (ALT) (SGPT), Aspartate transaminase (AST) (SGOT), or alkaline phosphatase (AP) => 3 x upper limit of normal (ULN) as determined at Visit 1.
  4. Estimated Glomerular filtration Rate (eGFR) <15 ml/min/1.73 m2 (severe renal impairment or End Stage Renal Disease (ESRD), Modification of Diet in Renal Disease (MDRD) formula), as determined during screening at Visit 1 and/or the need for maintenance dialysis.
  5. Any previous (or planned within next 12 months) bariatric surgery (open or laparoscopic) or intervention (gastric sleeve).
  6. Pre-planned coronary artery re-vascularisation (PCI, CABG) or any previous PCI and/or CABG <= 2 months prior informed consent.
  7. Known hypersensitivity or allergy to the investigational products or its excipients.
  8. Any previous or current alcohol or drug abuse that would interfere with trial participation in the opinion of the investigator.
  9. Participation in another trial with an investigational drug ongoing or within 2 months prior to visit 1 (screening).
  10. Pre-menopausal women (last menstruation = 1 year prior to informed consent) who are nursing or pregnant, are of child-bearing potential and are not practicing an acceptable method of birth control (acceptable methods of birth control include tubal ligation, transdermal patch, intra uterine devices/systems (IUDs/IUSs), oral, implantable or injectable contraceptives, sexual abstinence (if allowed by local authorities), double barrier method and vasectomised partner) or do not plan to continue using acceptable method of birth control throughout the study and do not agree to submit to periodic pregnancy testing during participation in the trial.
  11. Patients considered unreliable by the investigator concerning the requirements for follow up during the study and/or compliance with study drug administration, have a life expectancy less than 5 years for non-CV causes, or have cancer other than non-melanoma skin cancer within last 3 years, or has any other condition than mentioned which in the opinion of the investigator, would not allow safe participation in the study.
  12. Acute coronary syndrome (ACS), diagnosed <= 2 months prior to visit 1 (screening).
  13. Stroke or Transient Ischemic Attack (TIA) <= 3 months prior to visit 1 (screening).

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: TREATMENT
  • Allocation: RANDOMIZED
  • Interventional Model: PARALLEL
  • Masking: DOUBLE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
PLACEBO_COMPARATOR: Placebo
Drug: Placebo
placebo matching tablets
EXPERIMENTAL: Linagliptin
Drug: Linagliptin

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Time to the First Occurrence of Any of the Following Adjudication-confirmed Components of the Primary Composite Endpoint 3-point Major Adverse Cardiovascular (CV) Events (3-point MACE): CV Death, Non-fatal Myocardial Infarction (MI) or Non-fatal Stroke.
Time Frame: From randomization to individual end of observation; up to 4.3 years
Time to event analysis of patients with first occurrence of any of the following adjudication-confirmed components of the primary composite endpoint (3-point MACE): CV death, non-fatal MI or non-fatal stroke. The percentage of observed patients with first occurrence of any of the following adjudication-confirmed components of the primary composite endpoint (3-point MACE) was reported.
From randomization to individual end of observation; up to 4.3 years

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Time to the First Occurrence of Any of the Following Adjudication-confirmed Components: Renal Death, Sustained End Stage Renal Disease (ESRD), or Sustained Decrease of 40% or More in Estimated Glomerular Filtration Rate (eGFR).
Time Frame: From randomization to individual end of observation; up to 4.3 years

Time to the first occurrence of any of the following adjudication-confirmed components: renal death, sustained ESRD, or sustained decrease of 40% or more in eGFR.

The percentage of observed patients with first occurrence of any of the following adjudication-confirmed components: renal death, sustained ESRD, or sustained decrease of 40% or more in eGFR was reported.
From randomization to individual end of observation; up to 4.3 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Boehringer Ingelheim

Collaborators

Eli Lilly and Company

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (ACTUAL)

July 10, 2013

Primary Completion (ACTUAL)

January 18, 2018

Study Completion (ACTUAL)

January 18, 2018

Study Registration Dates

First Submitted

July 9, 2013

First Submitted That Met QC Criteria

July 9, 2013

First Posted (ESTIMATE)

July 12, 2013

Study Record Updates

Last Update Posted (ACTUAL)

April 4, 2019

Last Update Submitted That Met QC Criteria

March 21, 2019

Last Verified

March 1, 2019

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 1218.22
  • 2011-004148-23 (EUDRACT_NUMBER)

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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