The Evaluation of Bococizumab (PF-04950615;RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects (SPIRE-1)

June 14, 2018 updated by: Pfizer

Phase 3 Multi-center, Double-blind, Randomized, Placebo-controlled, Parallel Group Evaluation Of The Efficacy, Safety, And Tolerability Of Bococizumab (Pf-04950615) In Reducing The Occurrence Of Major Cardiovascular Events In High Risk Subjects.

This study evaluates the PCSK9 inhibitor, Bococizumab (PF-04950615;RN316), compared to placebo, in reducing the occurrence of major cardiovascular events, including cardiovascular death, myocardial infarction, stroke, and unstable angina requiring urgent revascularization, in high risk subjects who are receiving background lipid lowering therapy and have cholesterol laboratory values of LDL-C >/= 70 mg/dL (1.8 mmol/L) or non-HDL-C >/= 100 mg /dL (2.6 mmol/L).

Study Overview

Status

Terminated

Conditions

Cardiovascular Disease

Intervention / Treatment

Detailed Description

The trial was terminated prematurely on November 1, 2016, due to the emerging clinical profile and the evolving treatment and market landscape for lipid-lowering agents. These indicated that bococizumab was not likely to provide value to patients, physicians, or shareholders. The decision was not based on a recommendation by the independent Data Monitoring Committee to stop the program.

Study Type

Interventional

Enrollment (Actual)

16784

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Argentina
- - C.a.b.a., Argentina, C1119ACN
    - CIPREC - Centro de Investigacion y Prevencion Cardiovascular S.A.
  - Ciudad Autonoma De B. Aires, Argentina, C1405BUB
    - Cicemo - Consultorio de Investigaciones Clinicas E.M.O. S.R.L.
  - Ciudad Autonoma De Buenos Aires, Argentina, C1405BCK
    - Universidad Maimonides
  - Ciudad Autonoma de B. Aires, Argentina, C1093AAS
    - Instituto de Cardiología y Cirugía Cardiovascular - Fundación Favaloro
  - Ciudad Autonoma de B. Aires, Argentina, C1428ART
    - Instituto Cardiovascular de Buenos Aires
  - Ciudad Autonoma de Buenos Aires, Argentina, C1179AAB
    - Investigaciones Medicas IMOBA S.R.L.
  - Ciudad Autonoma de Buenos Aires, Argentina, C1430CKE
    - Centro de Investigacion: AXISMED S.R.L.
  - Cordoba, Argentina, X5003DCE
    - Instituto Médico DAMIC S.R.L.
  - Cordoba, Argentina, X5000BNB
    - ILAIM Instituto Latinoamericano de Investigaciones Medicas
  - Cordoba, Argentina, X5000EPU
    - Clinico Chutro SRL
  - Cordoba, Argentina, X5000EVQ
    - Centro de Investigaciones Clinicas "Instituto del Corazon"
  - Cordoba, Argentina, x5002AOQ
    - Clínica Privada Colombo
  - Cordoba, Argentina, X5006IKK
    - Centro Medico Luquez
  - Cordoba, Argentina, X5008KKF
    - Ipac Caraffa
  - Corrientes, Argentina, 3400
    - Instituto de Cardiologia de Corrientes "Juana Fca. Cabral"
  - Mendoza, Argentina, 5500
    - Hospital Central de Mendoza
  - Salta, Argentina, 4400
    - Cordis S.A.
  - Salta, Argentina, A4406BPF
    - Centro Cardiovascular Salta
  - San Luis, Argentina, D5702JRS
    - Instituto Cardiovascular San Luis A.E.
- Buenos Aires
  - Bahia Blanca, Buenos Aires, Argentina, B8000FTD
    - Instituto de Investigaciones Clinicas Bahia Blanca
  - Bahia Blanca, Buenos Aires, Argentina, B8001BXM
    - Hospital Italiano Regional del Sur
  - Ciudad Autonoma de B. Aires, Buenos Aires, Argentina, C1280AEB
    - Hospital Británico de Buenos Aires
  - Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1425DES
    - CEDIC - Consultorios Medicos
  - La Plata, Buenos Aires, Argentina, B1902COS
    - Framingham Centro Medico
  - Lanus Este, Buenos Aires, Argentina, B1824KAJ
    - CIMeL CHAHIN CHAHIN S.A.
  - Mar del Plata, Buenos Aires, Argentina, B7600FZN
    - Instituto de Investigaciones Clinicas Mar del Plata
  - Quilmes, Buenos Aires, Argentina, B1878GEG
    - Instituto de Investigaciones Clinicas Quilmes
  - Ramos Mejia, Buenos Aires, Argentina, B1704ETD
    - DIM Clínica Privada
  - Zarate, Buenos Aires, Argentina, B2800DGH
    - Instituto de Investigaciones Clinicas Zarate
- C.a.b.a.
  - C.a.b.a, C.a.b.a., Argentina, C1425AGC
    - Consultorios Asociados de Endocrinología e Investigación Clínica Aplicada
- Caba
  - C.a.b.a, Caba, Argentina, C1023AAB
    - Stat Research S.A.
- Cordoba
  - Villa Maria, Cordoba, Argentina, 5901
    - Clinica Privada de Especialidades Medicas
- Mendoza
  - Godoy Cruz, Mendoza, Argentina, M5501ARP
    - CIPADI Centro Integral de Prevencion y Atencion en Diabetes
- PCIA DE Buenos Aires
  - Bahia Blanca, PCIA DE Buenos Aires, Argentina, B8001DDU
    - Hospital Interzonal Gral. de Agudos Dr. Jose Penna
  - Ciudadela, PCIA DE Buenos Aires, Argentina, 1702
    - IMEP Instituto Medico Elsa Perez
  - Moron, PCIA DE Buenos Aires, Argentina, B1708CGU
    - Instituto Medico Aguero
  - San Martin, PCIA DE Buenos Aires, Argentina, B1650CSQ
    - Corporacion Medica de San Martin
- PCIA DE Chaco
  - Resistencia, PCIA DE Chaco, Argentina, H3500CDM
    - Cordis - Instituto del Corazon
- PCIA DE Formosa
  - Formosa, PCIA DE Formosa, Argentina, 3600
    - Hospital de Alta Complejidad "Pte. Juan Domingo Perón"
- PCIA DE Santa FE
  - Santa Fe, PCIA DE Santa FE, Argentina, S3000EOZ
    - Hospital Provincial Dr. José Maria Cullen
  - Santa Fe, PCIA DE Santa FE, Argentina, S3000FWO
    - Centro de Investigaciones Clinicas del Litoral S.R.L.
  - Santa Fe, PCIA DE Santa FE, Argentina, S3004CVS
    - Cedir S.A - Centro De Diagnostico Y Rehabilitacion S.A.
- PCIA DE Tucuman
  - San Miguel De Tucuman, PCIA DE Tucuman, Argentina, T4000IFL
    - Centro Modelo de Cardiología
- Pcia. DE Santa FE
  - Rosario, Pcia. DE Santa FE, Argentina, S2000CFK
    - Instituto de Hematologia y Medicina Clinica "Dr. Ruben A. Davoli"
- Provincia DE Buenos Aires
  - Coronel Suarez, Provincia DE Buenos Aires, Argentina, B7540GHD
    - Clinica Coronel Suarez S.A.
- Provincia DE Santa FE
  - Rosario, Provincia DE Santa FE, Argentina, S2000QID
    - Instituto Medico CENICLAR - Central de Investigaciones Clinicas Argentina -Sanatorio de la Mujer
- Santa FE
  - Rosario, Santa FE, Argentina, S2000CVD
    - Instituto de Investigaciones Clinicas Rosario
- Tucuman
  - San Miguel de Tucuman, Tucuman, Argentina, T4000IAF
    - Centro Medico CCBR Tucuman
Australia
- Australian Capital Territory
  - Garran, Australian Capital Territory, Australia, 2605
    - Canberra Hospital
- New South Wales
  - Camperdown, New South Wales, Australia, 2050
    - Royal Prince Alfred Hospital
  - Camperdown, New South Wales, Australia, 2050
    - Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders
  - Erina, New South Wales, Australia, 2250
    - Central Coast Neurosciences Research
  - Gosford, New South Wales, Australia, 2250
    - Gosford Hospital
  - Maroubra, New South Wales, Australia, 2035
    - Australian Clinical Research Network
  - St Leonards, New South Wales, Australia, 2065
    - Royal North Shore Hospital
- Queensland
  - Chermside, Queensland, Australia, 4032
    - Holy Spirit Northside Private Hospital Limited
  - Herston, Queensland, Australia, 4029
    - Royal Brisbane and Women'S Hospital
  - Milton, Queensland, Australia, 4064
    - Core Research Group Pty Ltd
  - Redcliffe, Queensland, Australia, 4020
    - Redcliffe Hospital
  - Sherwood, Queensland, Australia, 4075
    - AusTrials Pty Ltd
  - Southport, Queensland, Australia, 4215
    - Gold Coast University Hospital
- South Australia
  - Ashford, South Australia, Australia, 5035
    - SA Heart
  - Ashford, South Australia, Australia, 5035
    - Adelaide Medical Research
  - Daws Park, South Australia, Australia, 5041
    - Southern Adelaide Diabetes and Endocrine Service
  - Elizabeth Vale, South Australia, Australia, 5112
    - Department of Cardiology, Lyell McEwin Hospital
  - Fullarton, South Australia, Australia, 5063
    - Heart and Vascular Research
- Tasmania
  - Launceston, Tasmania, Australia, 7250
    - Launceston General Hospital
- Victoria
  - Box Hill, Victoria, Australia, 3128
    - Eastern Health - Box Hill Hospital
  - Epping, Victoria, Australia, 3076
    - The Northern Hospital
  - Geelong, Victoria, Australia, 3220
    - Barwon Health-The Geelong Hospital
  - Heidelberg West, Victoria, Australia, 3081
    - Austin Health - Heidelberg Repatriation Hospital
  - Melbourne, Victoria, Australia, 3004
    - Alfred Hospital
  - Parkville, Victoria, Australia, 3050
    - Royal Melbourne Hospital
- Western Australia
  - Fremantle, Western Australia, Australia, 6160
    - Fremantle Hospital
  - Joondalup, Western Australia, Australia, 6027
    - Joondalup Cardiovascular Trials Foundation Inc.
  - Joondalup, Western Australia, Australia, 6027
    - HPS Pharmacies
  - Nedlands, Western Australia, Australia, 6009
    - Sir Charles Gairdner Hospital, Heart Research Institute
Belgium
- - Antwerpen, Belgium, 2020
    - ZNA Campus Middelheim
  - Bonheiden, Belgium, 2820
    - Imeldaziekenhuis Bonheiden
  - Brugge, Belgium, 8000
    - A.Z. St.Jan AV Brugge
  - Brussels, Belgium, 1090
    - University Hospital Brussels - Centrum voor hart- en vaatziekten
  - Brussels, Belgium, 1090
    - University Hospital Brussels- Diabeteskliniek
  - De Pinte, Belgium, 9840
    - Private Practice 'Cardiovascular Detection Center'
  - Genk, Belgium, 3600
    - ZOL Campus Sint-Jan
  - Gent, Belgium, 9000
    - AZ Maria Middelares
  - Gilly, Belgium, 6060
    - Grand Hopital de Charleroi, Site St-Joseph
  - Hasselt, Belgium, 3500
    - Jessa Ziekenhuis
  - Hasselt, Belgium, 3500
    - Hygeia
  - Heusden-Zolder, Belgium, 3550
    - Sint-Franciskusziekenhuis
  - Huy, Belgium, 4500
    - Centre Hospitalier Regional de Huy
  - Ieper, Belgium, 8900
    - Jan Yperman Ziekenhuis, Cardiology
  - Leuven, Belgium, 3000
    - Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg
  - Leuven, Belgium, 3000
    - University hospitals Leuven - Cardiology department
  - Liege, Belgium, 4000
    - Centre Hospitalier Universitaire de Liège
  - Liege, Belgium, 4000
    - Centre Hospitalier Chretien
  - Linkebeek, Belgium, 1630
    - Huisartsenpraktijk Medilink
  - Massemen, Belgium, 9230
    - Huisartsenpraktijk Luc Capiau
  - Mechelen, Belgium, 2800
    - AZ Sint-Maarten
  - Mons, Belgium, 7000
    - C.H.U. Ambroise Pare
  - Overpelt, Belgium, 3900
    - Mariaziekenhuis vzw
  - Sint-Niklaas, Belgium, 9100
    - AZ Nikolaas
  - Tienen, Belgium, 3300
    - Dr. Luc De Wolf - Private Practice
- Antwerpen
  - Brasschaat, Antwerpen, Belgium, 2930
    - VZW Algemeen Ziekenhuis KLINA
  - Turnhout, Antwerpen, Belgium, 2300
    - AZ Turnhout - campus St. Elisabeth
- Brabant Flamand
  - Anderlecht, Brabant Flamand, Belgium, 1070
    - Hopital Erasme-Universite Libre de Bruxelles (ULB)
- Haine Saint PAUL
  - La Louviere, Haine Saint PAUL, Belgium, 7100
    - Centre hospitalier de Jolimont-Lobbes - Centre de Recherche Medicale de Jolimont
- Oost-vlaanderen
  - Aalst, Oost-vlaanderen, Belgium, 9300
    - Algemeen Stedelijk Ziekenhuis
  - Dendermonde, Oost-vlaanderen, Belgium, 9200
    - AZ Sint Blasius
  - Gent, Oost-vlaanderen, Belgium, 9000
    - AZ Sint Lucas Gent-Campus Sint Lucas
  - Ronse, Oost-vlaanderen, Belgium, 9600
    - AZ Glorieux
- West-vlaanderen
  - Kortrijk, West-vlaanderen, Belgium, 8500
    - AZ Groeninge-Campus Loofstraat
  - Oostende, West-vlaanderen, Belgium, 8400
    - AZ Damiaan
  - Veurne, West-vlaanderen, Belgium, 8630
    - A.Z. Sint-Augustinus Veurne
Brazil
- - Sao Paulo, Brazil, 01244-030
    - CPClin- Centro de Pesquisas Clinicas Ltda./Clinica Dr. Freddy Goldberg Eliaschewitz
  - Sao Paulo, Brazil, 01327-010
    - FGM-Clinica Paulista de Doencas Cardiovasculares
  - Sao Paulo, Brazil, 04024-900
    - SPDM Associacao Paulista para o Desenvolvimento da Medicina
  - Sao Paulo, Brazil, 04040-001
    - UNIFESP - Hospital Sao Paulo - Setor de Lipides, Aterosclerose e Biologia Vascular
  - Sao Paulo, Brazil, 05017-000
    - Instituto Jaqueline Scholz Issa e Mario Issa de Cardiologia LTDA
- BA
  - Salvador, BA, Brazil, 41810-010
    - Fundacao Bahiana de Cardiologia
  - Salvador, BA, Brazil, 41810-011
    - HBA S/A ASSISTENCIA MEDICA E HOSPITALAR-Hospital da Bahia
- Bahia
  - Salvador, Bahia, Brazil, 40170-130
    - Instituto Cardiopulmonar da Bahia
- CE
  - Fortaleza, CE, Brazil, 60430-140
    - Centro de Pesquisas em Diabetes e Doencas Endocrino-Metabolicas Ltda
- Ceara
  - Fortaleza, Ceara, Brazil, 60430-370
    - Hospital Universitario Walter Cantidio
  - Fortaleza, Ceara, Brazil, 60840-285
    - Hospital de Messejana Dr Carlos Alberto Studart Gomes
- Distrito Federal
  - Brasilia, Distrito Federal, Brazil, 70658-700
    - Instituto de Cardiologia do Distrito Federal
- Espirito Santo
  - Vitoria, Espirito Santo, Brazil, 29055-450
    - CEDOES - Centro de Diagnostico e Pesquisa da Osteoporose do Espirito Santo
- GO
  - Goiania, GO, Brazil, 74223-130
    - Via Medica - Clinica Medica Integrada Ltda - Barroso e Sebba Ltda
- Goias
  - Goiania, Goias, Brazil, 74093-300
    - INGOH - Instituto Goiano de Oncologia e Hematologia
- MG
  - Belo Horizonte, MG, Brazil, 30110-934
    - Hospital Felicio Rocho
  - Belo Horizonte, MG, Brazil, 30110-921
    - Hospital Lifecenter / Lifecenter Sistema de Saude S.A
  - Belo Horizonte, MG, Brazil, 30140-073
    - Hospital Universitário Sao José / FELUMA - MG
- Minas Gerais
  - Belo Horizonte, Minas Gerais, Brazil, 30110-021
    - Liga Mineira de Ressuscitacao Cardiopulmonar
  - Belo Horizonte, Minas Gerais, Brazil, 30140-062
    - Hospital Vera Cruz
  - Belo Horizonte, Minas Gerais, Brazil, 30140-073
    - Hospital Universitario Ciencias Medicas / Fundacao Educacional Lucas Machado
  - Belo Horizonte, Minas Gerais, Brazil, 30150-320
    - Liga Mineira de Ressucitacao cardiopulmonar
  - Belo Horizonte, Minas Gerais, Brazil, 30150240
    - CARDSEARCH/CARDRESEARCH - Cardiologia Assistencial e de Pesquisa LTDA
  - Uberlandia, Minas Gerais, Brazil, 38405-320
    - Universidade Federal de Uberlândia
  - Uberlandia, Minas Gerais, Brazil, 38411-186
    - Eurolatino Pesquisas Medicas Ltda
- PA
  - Belem, PA, Brazil, 66073-000
    - Universidade Federal do Para - Hospital Universitario Joao de Barros Barreto
- PE
  - Recife, PE, Brazil, 52020-010
    - Centro de Pesquisas Médicas Básica e Clínica Ltda
- PR
  - Campina Grande do Sul, PR, Brazil, 83430-000
    - Sociedade Hospitalar Angelina Caron/Hospital e Maternidade Angelina Caron
  - Curitiba, PR, Brazil, 80010-100
    - Irmandade da Santa Casa de Misericordia de Curitiba - Hospital Santa Casa de Misericordia
  - Curitiba, PR, Brazil, 80045-170
    - Quanta Diagnostico e Terapia / Medicina Nuclear Alto da XV
- Parana
  - Curitiba, Parana, Brazil, 80010-030
    - Hospital Santa Casa de Curitiba
  - Curitiba, Parana, Brazil, 80730-150
    - Nucleo De Pesquisa Clinica
  - Maringa, Parana, Brazil, 87015-000
    - Hospital Parana - Parana Medical Research Center - MARIMED SERVICOS MEDICOS S.A.
- Pernambuco
  - Recife, Pernambuco, Brazil, 52051-380
    - Hospital Agamenon Magalhaes
- RIO Grande DO SUL
  - Canoas, RIO Grande DO SUL, Brazil, 92425-055
    - Hospital Universitario - Associacao Educadora Sao Carlos - AESC
  - Pelotas, RIO Grande DO SUL, Brazil, 96015-290
    - Santa Casa de Misericordia de Pelotas
  - Porto Alegre, RIO Grande DO SUL, Brazil, 90035-903
    - Hospital de Clinicas de Porto Alegre
  - Porto Alegre, RIO Grande DO SUL, Brazil, 90110-270
    - Hospital Mae de Deus/Associacao Educadora Sao Carlos AESC/IMV - Instituto de Medicina Vascular
- RJ
  - Rio De Janeiro, RJ, Brazil, 22271-100
    - CCBR - Centro de Pesquisas e Analises Clinicas LTDA
  - Rio de Janeiro, RJ, Brazil, 22271-100
    - CCBR Brasil - Centro de Pesquisa e Analises Clinicas LTDA
- RN
  - Natal, RN, Brazil, 59020-035
    - Hemocardio S/S Ltda
- RS
  - Passo Fundo, RS, Brazil, 99010-080
    - Associacao Hospitalar Beneficente Sao Vicente de Paulo - Hospital Sao Vicente de Paulo
  - Porto Alegre, RS, Brazil, 90020-090
    - Irmandade da Santa Casa de Misericórdia de Porto Alegre - ISCMPA
  - Porto Alegre, RS, Brazil, 90610-000
    - Uniao Brasileira de Educacao e Assistencia (UBEA) - Hospital Sao Lucas da PUCRS
- SAO Paulo
  - Campinas, SAO Paulo, Brazil, 13010-001
    - Loema Medicina e Bem Estar- Centro Especializado em Cardiologia Ltda
  - Campinas, SAO Paulo, Brazil, 13020-431
    - Scentryphar Pesquisa Clinica
  - Campinas, SAO Paulo, Brazil, 13060-904
    - Hospital E Maternidade Celso Pierro PUC - Campinas - Sociedade Campineira de Educacao e Instrucao
  - Marilia, SAO Paulo, Brazil, 17515-000
    - ICM - Instituto do Coração de Marília
  - Paraiso, SAO Paulo, Brazil, 04005-004
    - Instituto Conceive
  - Santo Andre, SAO Paulo, Brazil, 09190-615
    - Hospital Estadual Mario Covas
  - Sao Jose Do Rio Preto, SAO Paulo, Brazil, 15015-750
    - Instituto Domingo Braile _ Braile Hospital Dia LTDA
  - Sao Jose do Rio Preto, SAO Paulo, Brazil, 15015210
    - IMC - Instituto de Molestias Cardiovasculares/Equipamentos Cardiovasculares Rio Preto Ltda
  - Sao Jose do Rio Preto, SAO Paulo, Brazil, 15090-000
    - Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto
  - Votuporanga, SAO Paulo, Brazil, 15500-003
    - Santa Casa de Misericórdia de Votuporanga
- SP
  - Campinas, SP, Brazil, 13087-567
    - CAEP - Centro Avancado de Estudos e Pesquisas Ltda.
  - Sao Paulo, SP, Brazil, 01228-000
    - Cpquali Pesquisa Clinica Ltda
  - Sao Paulo, SP, Brazil, 01232-010
    - Hospital Samaritano
  - Sao Paulo, SP, Brazil, 01233-000
    - Instituto de Conhecimento, Ensino e Pesquisa (Administrative local)
  - Sao Paulo, SP, Brazil, 01407-200
    - Comed Care Empresa de Atendimento Clinico Geral - LTDA - Hospital Total Care
  - Sao Paulo, SP, Brazil, 04062-001
    - CCBR Sao Paulo
  - Sao Paulo, SP, Brazil, 04266-010
    - CEPIC - Centro Paulista de Investigação Clínica e Serviços Médicos Ltda.
- Santa Catarina
  - Blumenau, Santa Catarina, Brazil, 89010-906
    - Hospital Santa Isabel
  - Sao Jose, Santa Catarina, Brazil, 88103-450
    - Insituto de Cardiologia de Santa Catarina
Canada
- - Quebec, Canada, G1V 4W2
    - Clinique des Maladies Lipidiques de Québec
  - Quebec, Canada, G1G 3Y8
    - Recherche Clinique Sigma Inc
- Alberta
  - Calgary, Alberta, Canada, T2H 2G4
    - LMC Diabetes & Endocrinology (Calgary)
  - Calgary, Alberta, Canada, T2N 4Z6
    - Foothills Hospital/University of Calgary
  - Calgary, Alberta, Canada, T2V 4J2
    - Nanji Professional Corporation
- British Columbia
  - Kelowna, British Columbia, Canada, V1Y 1V6
    - The Medical Arts Health Research Group
  - Surrey, British Columbia, Canada, V3V 0C6
    - SMH Cardiology Clinical Trials
  - Surrey, British Columbia, Canada, V3V 0C6
    - Dr Stephen Pearce Inc
  - Surrey, British Columbia, Canada, V3V 0C6
    - Dr. Adam Yeung Inc.
  - Surrey, British Columbia, Canada, V3V 0C6
    - Dr. Micheal Kanakos Inc
  - Surrey, British Columbia, Canada, V3V 0C6
    - Dr. Raymond Dong Inc.
  - Surrey, British Columbia, Canada, V3V 0C6
    - Dr. Richard Bon Inc.
  - Surrey, British Columbia, Canada, V3V 0C6
    - Dr. Stephen S. Cheung Inc.
  - Surrey, British Columbia, Canada, V3V 1N1
    - Dr Peter K.H. Tan Inc
  - Surrey, British Columbia, Canada, V3V 1N1
    - Dr. Dante E. Manyari Inc.
  - Surrey, British Columbia, Canada, V3V 1N1
    - Dr. Stephanie Au, Inc.
  - Surrey, British Columbia, Canada, V3V 1N1
    - SMH Cardiology Clinical Trials Inc.
  - Surrey, British Columbia, Canada, V3W 3C3
    - Dr. Kapil M. Bhagirath Medical Services Corporation
  - Victoria, British Columbia, Canada, V8R 4R2
    - Victoria Heart Institute Foundation
  - Victoria, British Columbia, Canada, V8T 5G4
    - Discovery Clinical Services Ltd.
- Manitoba
  - Winnipeg, Manitoba, Canada, R2H 2A6
    - St. Boniface Hospital
  - Winnipeg, Manitoba, Canada, R2V 3P4
    - Unicity Laboratory Services
  - Winnipeg, Manitoba, Canada, R2V 4W3
    - Rivergrove Medical Clinic
- New Brunswick
  - Moncton, New Brunswick, Canada, E1G 1A7
    - G.A. Research Associates Ltd.
  - Saint John, New Brunswick, Canada, E2L 4L2
    - Cardiology Research Associates of New Brunswick
- Newfoundland and Labrador
  - St. John's, Newfoundland and Labrador, Canada, A1B 3V6
    - Health Sciences Centre
- Ontario
  - Brampton, Ontario, Canada, L6S 0C9
    - LMC Diabetes & Endocrinology (Brampton)
  - Burlington, Ontario, Canada, L7M 4Y1
    - JBN Medical Diagnostic Services Inc.
  - Burlington, Ontario, Canada, L7M 4Y1
    - Aviva Clinical Trial Group Inc.
  - Burlington, Ontario, Canada, L7R 4E2
    - Philippe R. Beaudry Medicine Professional Corporation
  - Cambridge, Ontario, Canada, N1R 6V6
    - Cambridge Cardiac Care Centre
  - Cambridge, Ontario, Canada, N1R 7R1
    - Vizel Cardiac Research, Saul Vizel Professional Medicine Corporation
  - Collingwood, Ontario, Canada, L9Y 1W3
    - Moran Medical Centre
  - Fort Erie, Ontario, Canada, L2A 1Z3
    - C & L Research
  - Hamilton, Ontario, Canada, L8K 3P3
    - Parkdale Medical Centre
  - London, Ontario, Canada, N6G 2M1
    - Western University - WCPHFM
  - London, Ontario, Canada, N6G 2V4
    - Stroke Prevention & Atherosclerosis Research Centre (SPARC)-Siebens-Drake Research Institute
  - Markham, Ontario, Canada, L6B 0P9
    - LMC Diabetes & Endocrinology (Markham)
  - Newmarket, Ontario, Canada, L3Y 8C3
    - Newmarket Cardiology Research Group
  - Oakville, Ontario, Canada, L6M 1M1
    - LMC Clinical Research Inc. (Oakville)
  - Oakville, Ontario, Canada, L6M 1M1
    - LMC Oakville
  - Oshawa, Ontario, Canada, L1J 2K1
    - The Office of Dr. James Cha
  - Peterborough, Ontario, Canada, K9J 0B2
    - Kawartha Cardiology Clinical Trials
  - Sarnia, Ontario, Canada, N7T 4X3
    - London Road Diagnostic Clinic and Medical Centre
  - Sarnia, Ontario, Canada, N7T 4X3
    - Sarnia Institute of Clinical Research
  - Scarborough, Ontario, Canada, M1E 5E9
    - Scarborough Cardiology Research Associates Inc.
  - Smiths Falls, Ontario, Canada, K7A 4W8
    - Canadian Centre for Research on Diabetes
  - Sudbury, Ontario, Canada, P3E 2N8
    - Brian Y.L. Wong Medicine Professional Corporation
  - Thornhill, Ontario, Canada, L4J 8L7
    - Lmc Diabetes & Endocrinology (Thornhill)
  - Toronto, Ontario, Canada, M9V 4B4
    - Dr. Anil K. Gupta Medicine Professional Corporation
  - Toronto, Ontario, Canada, M3J 2C5
    - Canadian Phase Onward, Inc.
  - Toronto, Ontario, Canada, M3J 1N2
    - JJ Dig Research Ltd
  - Toronto, Ontario, Canada, M4G 3E8
    - Lmc Diabetes & Endocrinology (Bayview)
  - Waterloo, Ontario, Canada, N2T 0C1
    - Dr. Mohan Babapulle Medicine Professional Corporation
  - Weston, Ontario, Canada, M9N 1W4
    - Dr. Louis Yao
- Quebec
  - Chicoutimi, Quebec, Canada, G7H 7K9
    - Ecogene-21
  - Chicoutimi, Quebec, Canada, G7H 7Y8
    - Q & T Research Chicoutimi
  - Gatineau, Quebec, Canada, J8Y 6S8
    - Q&T Recherche Outaouais Inc.
  - Laval, Quebec, Canada, H7T 2P5
    - Centre de Recherche Clinique de Laval
  - Mirabel, Quebec, Canada, J7J 2K8
    - Omnispec clinical research inc
  - Montreal, Quebec, Canada, H1T 1C8
    - Montreal Heart Institute
  - Montreal, Quebec, Canada, H2Y 1S1
    - Diex Research Montreal, Inc.
  - Sherbrooke, Quebec, Canada, J1G 2E8
    - Centre Hospitalier Universitaire de Sherbrooke- Hotel-Dieu
  - St Charles-Borromee, Quebec, Canada, J6E 6J2
    - Centre integre de sante et de services sociaux de Lanaudiere (CISSSL)
  - St-Georges, Beauce, Quebec, Canada, G5Y 4T8
    - Centre intégré de Santé et de Services Sociaux de Chaudière-Appalaches (CISSS-CA)
  - St-Jerome, Quebec, Canada, J7Z 5T3
    - CISSS des Laurentides-Point de Service de St-Jerome- Comite d'ethique de la recherche
  - St-Jerome, Quebec, Canada, J7Z 5T3
    - St-Jerome Medical Research Inc.
  - Ville Saint-Laurent, Quebec, Canada, H4T 1Z9
    - LMC Diabetes & Endocrinology (Montreal)
Chile
- - Puerto Varas, Chile, 5550170
    - Quantum Research
- Metropolitana
  - Providencia Santiago, Metropolitana, Chile, 7500710
    - Biomedica Research Group
  - Santiago, Metropolitana, Chile, 7500021
    - CICAB
  - Santiago, Metropolitana, Chile, 7500739
    - SMOLAM
  - Santiago, Metropolitana, Chile, 8053095
    - Hopsital y CRS El Pino
  - Santiago, Metropolitana, Chile, 8207257
    - Complejo Asitencial Dr. Sotero del Rio
- Region DE LA Araucania
  - Temuco, Region DE LA Araucania, Chile, 4781156
    - Centro de Investigacion Clinica del Sur
- Region DE LOS Lagos
  - Osorno, Region DE LOS Lagos, Chile, 5311092
    - Corporacion de Beneficencia Osorno
- Region DE Magallanes
  - Punta Arenas, Region DE Magallanes, Chile, 6210005
    - Hospital Clinico Magallanes
- Region Metropolitana
  - Santiago, Region Metropolitana, Chile, 7500710
    - Servicios Medicos Godoy
China
- - Beijing, China, 100020
    - Beijing Chao-Yang Hospital
  - Beijing, China, 100037
    - Fuwai Hospital, CAMS & PUMC
  - Shanghai, China, 200080
    - Shanghai General Hospital
  - Tianjin, China, 300120
    - Tianjin Union Medical Center
  - Zhejiang, China, 317000
    - Taizhou Hospital of Zhejiang Province
- Guangdong
  - Guangzhou, Guangdong, China, 510080
    - Guangdong General Hospital
- Hainan
  - Haikou, Hainan, China, 570208
    - Haikou People's Hospital
- Heilongjiang
  - Harbin, Heilongjiang, China, 150001
    - The 2nd Affiliated Hospital Of Harbin Medical University
  - Harbin, Heilongjiang, China, 150001
    - The First Affiliated Hospital Of Harbin Medical University
  - Harbin, Heilongjiang, China, 150001
    - The First Affiliated Hospital of Habrin Medical University
- Henan
  - Zhengzhou, Henan, China, 450052
    - The First Affiliated hospital of Zhengzhou University
- Hubei
  - Wuhan, Hubei, China, 430014
    - The Central Hospital of Wuhan
  - Wuhan, Hubei, China, 430033
    - Pu Ai Hospital of Wuhan City
- Hunan
  - Changde, Hunan, China, 415003
    - Changde First People's Hospital
  - Changsha, Hunan, China, 410004
    - Changsha Central Hospital
  - Changsha, Hunan, China, 410005
    - Hunan Provincial People's Hospital
  - Xiangtan, Hunan, China, 411100
    - Xiangtan City Central Hospital
  - Zhuzhou, Hunan, China, 412007
    - Zhuzhou Central Hospital
- Inner Mongolia
  - Baotou, Inner Mongolia, China, 014010
    - Inner Mongolia Baogang Hospital
  - Hohhot, Inner Mongolia, China, 010017
    - Inner Mongolia Autonomous Region People's Hospital
- Jiangsu
  - Jiangsu, Jiangsu, China, 214023
    - Wuxi People's Hospital
  - Suzhou, Jiangsu, China, 215021
    - Suzhou Kowloon Hospital Shanghai Jiaotong University School of Medicine
  - Xuzhou, Jiangsu, China, 221002
    - The Affiliated Hospital of Xuzhou Medical College
- Jilin
  - Changchun, Jilin, China, 130021
    - The First Hospital of Jilin University
  - Changchun, Jilin, China, 130021
    - Jilin Province People's Hospital
  - Changchun, Jilin, China, 130033
    - China-Japan Union Hospital of Jilin University
- Ningxia
  - Yinchuan, Ningxia, China, 750001
    - General Hospital of Ningxia Medical University
- Shandong
  - Qingdao, Shandong, China, 266003
    - The Affiliated Hospital of Qingdao University
- Xinjiang
  - Urumqi, Xinjiang, China, 830054
    - The First Affiliated Hospital of Xinjiang Medical University
- Zhejiang
  - Ningbo, Zhejiang, China, 315010
    - Ningbo First Hospital
Colombia
- Antioquia
  - Medellin, Antioquia, Colombia, 00000
    - Hospital Pablo Tobon Uribe
  - Medellin, Antioquia, Colombia
    - Centro de Investigacion Clinica Avanzada y Multidisciplinaria CICLAM
  - Medellin, Antioquia, Colombia
    - Centro de Medicina del Ejercicio y Rehabilitacion Cardiac - CEMDE S.A.
  - Medellin, Antioquia, Colombia
    - Rodrigo Botero S.A.S.
- Atlantico
  - Barranquilla, Atlantico, Colombia, 080020
    - Clinica de la Costa Ltda
  - Barranquilla, Atlantico, Colombia, 80020
    - Centro Cientifico Asistencial Jose Luis Accini S.A.S.
  - Barranquilla, Atlantico, Colombia
    - Corazon Ips Sas.
  - Barranquilla, Atlantico, Colombia
    - Fundacion del Caribe para la Investigacion Biomedica - Fundacion BIOS
- Bolivar
  - Cartagena, Bolivar, Colombia
    - Centro de Diagnostico Cardiologico LTDA.
- Caldas
  - Manizales, Caldas, Colombia
    - Asociacion IPS Medicos Internistas de Caldas
- Cundinamarca
  - Bogota D C, Cundinamarca, Colombia, 00
    - Hospital Universitario San Ignacio
  - Bogota D.C, Cundinamarca, Colombia, 110221
    - Dexadiab Servicios Medicos LTDA
  - Bogota D.C, Cundinamarca, Colombia, 111211
    - Caja de Compensacion Familiar CAFAM, Sede Centro de Atencion en Salud CAFAM FLORESTA
  - Bogota D.C., Cundinamarca, Colombia, 110911
    - Medplus Medicina Prepagada S.A.
  - Bogota D.C., Cundinamarca, Colombia
    - Instituto de Investigacion Endocrinologia y Prevencion Metabolica - ENDOCARE LTDA.
  - Bogota D.C., Cundinamarca, Colombia
    - Simedics Ips Sas
  - Bogota D.C., Cundinamarca, Colombia
    - Solano & Terront Servicios Medicos Ltda-Establecimiento Comercial UNIENDO
  - Zipaquira, Cundinamarca, Colombia, 250252
    - Healthy Medical Center S.A.S
- Narino
  - Pasto, Narino, Colombia
    - Fundación Centro de Obesidad y Metabolismo COMETA
- Santander
  - Bucaramanga, Santander, Colombia
    - Instituto del Corazon de Bucaramanga S.A.
  - Floridablanca, Santander, Colombia
    - Fundación Cardiovascular de Colombia - Instituto del Corazón Floridablanca
  - Floridablanca, Santander, Colombia, 681004
    - Fundación Cardiovascular de Colombia - Instituto del Corazón Floridablanca
- Valle DEL Cauca
  - Cali, Valle DEL Cauca, Colombia, 760001
    - Fundación Reina Isabel
Czechia
- - Brno, Czechia, 602 00
    - CCBR Czech Brno, s.r.o.
  - Havirov, Czechia, 73601
    - DIKa centrum s.r.o., Kardiologicka a interni ambulance
  - Hradec Kralove, Czechia, 500 05
    - Fakultni nemocnice Hradec Kralove
  - Hradec Kralove, Czechia, 50005
    - Fakultni nemocnice Hradec Kralove
  - Litovel, Czechia, 784 01
    - Fremlova Apotheca s.r.o.
  - Litovel, Czechia, 784 01
    - Kardio Interna s.r.o.
  - Olomouc, Czechia, 775 20
    - Fakultni Nemocnice Olomouc
  - Pardubice, Czechia, 530 02
    - CCBR Czech a.s.
  - Plzen, Czechia, 326 00
    - Kardiologie Plzen s.r.o.
  - Praha, Czechia, 14059
    - Centrum kardiovaskularni prevence 1. LF UK a TN
  - Praha 10, Czechia, 100 34
    - Fakultni nemocnice Kralovske Vinohrady
  - Praha 2, Czechia, 128 08
    - Fakultní poliklinika Všeobecné fakultní nemocnice v Praze
  - Praha 3, Czechia, 130 00
    - CCBR Czech Prague, s.r.o
  - Praha 5, Czechia, 158 00
    - Kardiologie a interni lekarstvi
  - Praha 6, Czechia, 160 00
    - NEFROMED, s.r.o.
  - Roznov pod Radhostem, Czechia, 756 61
    - Interna a kardiologie s.r.o.
  - Svitavy, Czechia, 568 25
    - Nemocnice Pardubickeho kraje, a.s., Svitavska nemocnice
  - Tabor, Czechia, 390 02
    - Ordinace V Tabacce s.r.o.
  - Uherske Hradiste 1, Czechia, 686 01
    - MUDr. Antonin Dufka, kardiologicka ambulance
  - Uherske Hradiste 1, Czechia, 686 01
    - MUDr. Nina Zemkova s.r.o.
  - Znojmo, Czechia, 66902
    - KIGE s.r.o.
- Jihomoravsky KRAJ
  - Brno, Jihomoravsky KRAJ, Czechia, 638 00
    - Kardiologicka ambulance
- Kralovehradecky KRAJ
  - Broumov, Kralovehradecky KRAJ, Czechia, 55001
    - EDUMED s.r.o.
  - Jaromer, Kralovehradecky KRAJ, Czechia, 55101
    - EDUMED s.r.o.
  - Trutnov, Kralovehradecky KRAJ, Czechia, 54101
    - Kardiologicka ambulance
  - Trutnov, Kralovehradecky KRAJ, Czechia, 54101
    - Lekarna na Poliklinice
- Moravskoslezsky KRAJ
  - Ostrava, Moravskoslezsky KRAJ, Czechia, 70200
    - MUDr. Jan Vrkoc s.r.o.
- Pardubicky KRAJ
  - Pardubice, Pardubicky KRAJ, Czechia, 53002
    - PV-Kardiologie s.r.o.
Denmark
- - Aabenraa, Denmark, 6200
    - Aabenraa Hospital Hjertemedicinsk klinik Kredslobscentret, SHS
  - Aabenraa, Denmark, 6200
    - Sygehus Sonderjylland Aabenraa
  - Aalborg, Denmark, 9000
    - Aalborg Universitetshospital, Lipidklinikken
  - Aalborg, Denmark, 9000
    - CCBR Aalborg
  - Aarhus, Denmark, 8200
    - Aarhus Universitetshospital Skejby, Hjertesygdomme ¿ Klinisk Forskning
  - Ballerup, Denmark, DK - 2750
    - CCBR Ballerup
  - Copenhagen NV, Denmark, 2400
    - Bispebjerg og Frederiksberg Hospital
  - Esbjerg, Denmark, 6700
    - Sydvestjysk Sygehus, Hjertemedicinsk Projektgruppe
  - Frederiksberg, Denmark, 2000
    - Frederiksberg Hospital
  - Glostrup, Denmark, 2600
    - Glostrup Hospital
  - Herlev, Denmark, 2730
    - Herlev Universitetshospital
  - Herning, Denmark, 7400
    - Regionshospitalet Herning
  - Hillerod, Denmark, 3400
    - Hillerod Hospital
  - Hvidovre, Denmark, 2650
    - Hvidovre Universitetshospital
  - Kobenhavn O, Denmark, 2100
    - Karkirurgisk Klinisk
  - Kobenhavn S., Denmark, 2300
    - Amager Hospital
  - Koege, Denmark, 4600
    - Region Sjaelland Sygehus Nord, Koge Sygehus
  - Kolding, Denmark, 6000
    - Kolding Sygehus
  - Naestved, Denmark, 4700
    - Region Sjaelland Naestved Sygehus
  - Nykobing F., Denmark, 4800
    - Nykobing F. Sygehus-Medicinsk afdeling
  - Randers, Denmark, 8930
    - Regionshospitalet Randers
  - Silkeborg, Denmark, 8600
    - Regionshospitalet Silkeborg, Hjerte Projektkontor
  - Slagelse, Denmark, 4200
    - Slagelse Sygehus
  - Svendborg, Denmark, 5700
    - Svendborg Sygehus
  - Vejle, Denmark, DK 7100
    - CCBR Vejle
  - Viborg, Denmark, 8800
    - Hospitalsenheden Midt, Regionshospital Viborg
Finland
- - Espoo, Finland, 02740
    - HYKS Jorvin sairaala
  - Hameenlinna, Finland, 13100
    - Linnan Klinikka Oy
  - Helsinki, Finland, 00290
    - Helsinki University Central Hospital
  - Helsinki, Finland, 00180
    - Geri-Med Oy
  - Helsinki, Finland, FI-00290
    - Helsingin yliopistollinen keskussairaala, Sisaetaudit ja kuntoutus, Biomedicum 2U
  - Joensuu, Finland, 80100
    - Ita-Suomen laakarikeskus Oy
  - Jyvaskyla, Finland, 40620
    - StudyCor Oy
  - Kerava, Finland, 04200
    - Laeaekaerikeskus Aava Kerava
  - Kinkomaa, Finland, 40930
    - Menoa oy
  - Kokkola, Finland, 67200
    - Kokkolan Keskussairaala
  - Kotka, Finland, 48600
    - Mewell liikuntaklinikka
  - Kuopio, Finland, 70100
    - Itae-Suomen Laeaekaeritalo
  - Kuopio, Finland, 70100
    - Terveystalo Kuopio
  - Oulu, Finland, 90220
    - Oulu University Hospital
  - Oulu, Finland, 90100
    - Oulu Mentalcare Oy
  - Oulu, Finland, 90100
    - Terveystalo Oulu, Diapolis
  - Pori, Finland, 28100
    - Porin Lääkäritalo Oy
  - Siilinjarvi, Finland, 71800
    - Terveystalo Siilinjarvi
  - Tampere, Finland, 33520
    - FinnMedi Oy
  - Turku, Finland, 20520
    - Turku University Hospital
  - Turku, Finland, 20100
    - Terveystalo Pulssi
  - Vantaa, Finland, 01600
    - Vantaan Tutkimuskeskus
  - Ylitornio, Finland, 95600
    - Ylitornion Terveyskeskus
France
- - Besancon, France, 25000
    - CHU Jean Minjoz Cardiologie
  - Bordeaux, France, 33076
    - Groupe Hospitalier de Pellegrin Hopital Pellegrin
  - Bourg En Bresse Cedex 10000, France, 01012
    - Centre Hospitalier De Bourg En Bresse - Hopital Fleyriat
  - Corbeil-Essonnes, France, 91106
    - centre hospitalier Sub-Francilien
  - Essey-Les-Nancy, France, 54270
    - Scp Cardiovasculaire De L'Est
  - Le Coudray, France, 28630
    - Centre Hospitalier Louis Pasteur
  - Lille, France, 59000
    - Hôpital La Louvière
  - Lomme, France, 59462
    - Centre Hospitalier Saint Philibert
  - Lyon Cedex 03, France, 69394
    - Hopital Cardiovasculaire et Pneumologique Louis Pradel
  - Montpellier cedex 5, France, 34295
    - Hôpital Arnaud de Villeneuve - CHU Montpellier
  - Nantes, France, 44093
    - CHU de Nantes - Hôpital Nord Laennec
  - Nantes, France, 44200
    - Nouvelles Cliniques Nantaises
  - Nice Cedex 1, France, 06002
    - CHU de Nice - Hopital Pasteur
  - Pessac cedex, France, 33604
    - Hopital Cardiologique
  - Poitiers Cedex, France, 86021
    - CHU de Poitiers
  - Rennes Cedex 9, France, 35033
    - CHU de Renes Hopital de Pontchaillou
  - Toulouse cedex 9, France, 31059
    - CHU de Toulouse
  - Tourcoing, France, 59200
    - Hospital Cuy Chatilliez
  - Tours Cedex 9, France, 37044
    - Hôpital Trousseau
  - Valenciennes, France, 59300
    - Centre Hospitalier (GH) de Valenciennes
  - Valenciennes, France, 59300
    - Polyclinique Vauban
Germany
- - Altenburg, Germany, 04600
    - Klinikum Altenburger Land GmbH
  - Bad Homburg, Germany, 61348
    - Forschungszentrum Dr. med Irma Schoell
  - Berlin, Germany, 13353
    - Deutsches Herzzentrum Berlin
  - Berlin, Germany, 12627
    - Synexus Clinical Research GmbH
  - Berlin, Germany, 10115
    - Institut fuer Klinische Forschung und Entwicklung(IKFE) Berlin GmbH
  - Berlin, Germany, 10117
    - Klinische Forschung Berlin- Mittte GmbH
  - Berlin, Germany, 12157
    - POLIKUM Institut GmbH, Polikum Berlin Friedenau
  - Berlin, Germany, 12559
    - DRK Kliniken Berlin Kopenick, Zentrum Klinische Forschung
  - Berlin, Germany, 13597
    - Medizinisches Versorgungszentrum am Bahnhof Spandau
  - Bielefeld, Germany, 33604
    - Staedtische Kliniken Bielefeld Gem. GmbH - Klinikum Mitte
  - Bochum, Germany, 44787
    - Synexus Clinical Research GmbH
  - Bochum, Germany, 44787
    - Bochum Research Centre-Synexus Clinical Research GmbH
  - Burg-Spreewald, Germany, 03096
    - MediClin Reha-Zentrum Spreewald
  - Coburg, Germany, 96450
    - Klinikum Coburg
  - Dortmund, Germany, 44137
    - St. Johannes-Hospital
  - Dortmund, Germany, 44137
    - Kardiologische Praxisgemeinschaft
  - Dortmund, Germany, 44141
    - Gemeinschaftspraxis fuer Kardiologie Dres. Med. Willgeroth/Wetzel
  - Dresden, Germany, 01069
    - Klinsche Forschung Dresden GmbH
  - Dresden, Germany, 01277
    - Praxis Dr. med. Christoph Axthelm
  - Dresden, Germany, 01307
    - GWT-TUD GmbH, Studienzentrum Professor Hanefeld
  - Essen, Germany, 45355
    - Medizentrum Essen Borbeck
  - Essen, Germany, 45355
    - Gemeinschaftspraxis Dr. Hagemann/Breiderhoff/Durfeld
  - Essen, Germany, 45355
    - Studienzentrum
  - Essen, Germany, 45359
    - Gemeinschaftspraxis Dres. Dirk Weber, Ulrich Weber, Heiner Saueressig, Birte Turner und Georg
  - Falkensee, Germany, 14612
    - Schwerpunktpraxis Dr. Luedemann fuer Diabetes Gefaess- und Ernaehrungsmedizin
  - Frankfurt, Germany, 60313
    - Synexus Clinical Research GmbH
  - Frankfurt, Germany, 60594
    - ClinPhenomics GmbH & Co KG, Studienzentrum
  - Frankfurt am Main, Germany, 60596
    - IKF Institut fuer klinische Forschung Frankfurt
  - Greifswald, Germany, 17475
    - Klinik und Poliklinik fuer Innere Medizin B - Kardiologie, Angiologie, Pulmologie
  - Hamburg, Germany, 22041
    - Cardiologicum Hamburg
  - Hamburg, Germany, 22415
    - Praxis Dr. med Cornelia Brauer
  - Hannover, Germany, 30159
    - Klinische Forschung Hannover-Mitte GmbH
  - Homburg, Germany, 66421
    - Universitaetsklinikum des Saarlandes Klinik fuer Innere Medizin III
  - Kamp-Lintfort, Germany, 47475
    - Praxis Dr. Heister
  - Kassel, Germany, 34121
    - Studienzentrum Dr. Appel
  - Koeln, Germany, 51069
    - Zentrum fuer klinische Forschung
  - Kuenzing, Germany, 94550
    - Gemeinschaftspraxis Dr. Klein / Minnich
  - Lahr, Germany, 77933
    - Klinik fur Innere Medizin, Kardiologie und Angiologie MediClin Herzzentrum Lahr/Baden.
  - Leipzig, Germany, 04249
    - Gemeinschaftspraxis Dr. med. Heidrun Taeschner und Dr. med. Susanne Bonigut
  - Leipzig, Germany, 04103
    - Synexus Leipzig Clinical Research Centre
  - Leipzig, Germany, 04109
    - SIBAmed Studienzentrum GmbH & Co. KGKG
  - Leverkusen, Germany, 51375
    - Klinikum Leverkusen gGmbH
  - Ludwigshafen, Germany, 67063
    - Klinikum der Stadt Ludwigshafen am Rhein gGmbH
  - Luedenscheid, Germany, 58515
    - Maerkische Kliniken GmbH, Klinikum Luedenscheid, Innere III
  - Lunen, Germany, 44534
    - Klinikum Lunen, St. Marienhospital
  - Magdeburg, Germany, 39120
    - SMO.MD GmbH, Zentrum fuer klinische Studien Site Management and Clinical Research Unit
  - Mainz, Germany, 55116
    - Pfuetzner Science & Health Institute-Gmbh
  - Mannheim, Germany, 68165
    - Ze:ro Arztpraxen Dr. med. Salbach
  - Muenchen, Germany, 80636
    - Klinikum fuer Herz- & Kreislauferkrankungen
  - Munchen, Germany, 80336
    - Klinikum der Universität München
  - Munich, Germany, 80636
    - Klinikum Fur Herz- & Kreislauferkrankungen
  - Munich, Germany, 81737
    - Staedtisches Klinikum Muenchen GmbH, Klinikum Neuperlach
  - Northeim, Germany, 37154
    - Kardiologische Praxis Northeim
  - Nurnberg, Germany, 90402
    - Gemeinschaftspraxis Drs Haggenmiller/Jeserich, Kardiologie, Angiologie, Innere Medizin
  - Offenbach, Germany, 63071
    - Allgemeinmedizinisch-Internistische Praxisgemeinschaft
  - Rodgau, Germany, 63110
    - Praxis Dres. Med Naudts und Nowack
  - Rudersdorf, Germany, 15562
    - Klinik Am See - Klinik Am See - Rehabilitationszentrum Fur Innere Medizin
  - Schwerin, Germany, 19055
    - Klinische Forschung Schwerin GmbH
  - Soest, Germany, 59494
    - Kardiologische Gemeinschaftspraxis Dres Med. Gerke/Buerger
  - Stuhr-Brinkum, Germany, 28816
    - Praxisgemeinschaft Stuhr-Brinkum
  - Stuttgart, Germany, 70376
    - Robert-Bosch-Krankenhaus
  - Ulm, Germany, 89081
    - Universitaetsklinikum Ulm
  - Warendorf, Germany, 48231
    - Josephs-Hospital Warendorf Med. Klinik II, Kardiologie/Angiologie
  - Wermsdorf, Germany, 04779
    - Kardiologische Praxis
  - Witten, Germany, 58455
    - ForschungszentrumRuhr KliFoCenter GmbH
- Baden-wuerttemberg
  - Bad Krozingen, Baden-wuerttemberg, Germany, 79189
    - Universitaets Herzzentrum Freiburg Bad Krozingen
- Baden-wurttemberg
  - Heidelberg, Baden-wurttemberg, Germany, 69120
    - Medizinische Universitaetsklinik Heidelberg
- Hessen
  - Fulda, Hessen, Germany, 36037
    - Gemeinschaftspraxis im Altstadt Carree
- Rheinland Pfalz
  - Neuwied, Rheinland Pfalz, Germany, 56564
    - Zentrum Klinische Studien Neuwied (ZKSN)
- Rhineland-palatinate
  - Schwabenheim, Rhineland-palatinate, Germany, 55270
    - Gemeinschaftspraxis Schwabenheim
Hungary
- - Balatonfured, Hungary, 8230
    - DRC Kft.
  - Balatongyorok, Hungary, 8313
    - DRC Kft.
  - Bekescsaba, Hungary, 5600
    - Kardiologiai Maganrendelo
  - Berettyoujfalu, Hungary, 4100
    - Grof Tisza Istvan Korhaz Berettyoujfalu
  - Budapest, Hungary, 1088
    - Semmelweis Egyetem
  - Budapest, Hungary, 1096
    - Gottsegen György Országos Kardiológiai Intézet
  - Budapest, Hungary, 1036
    - Synexus Magyarország Kft
  - Budapest, Hungary, 1021
    - Budapesti Szent Ferenc Korhaz
  - Budapest, Hungary, 1106
    - Bajcsy-Zsilinszky Korhaz Es Rendelointezet
  - Budapest, Hungary, 1085
    - Szent Rokus Korhaz
  - Budapest, Hungary, 1097
    - Egyesitett Szent Istvan es Szent Laszlo Korhaz-Rendelointezet
  - Budapest, Hungary, 1125
    - Szent Janos Korhaz es Eszak-budai Egyesitett Korhazak, III. Belgyogyaszat-Kardiologiai Osztaly
  - Debrecen, Hungary, 4032
    - Debreceni Egyetem, I. sz. Belgyogyaszati Klinika
  - Debrecen, Hungary, 4032
    - Synexus Magyarorszag Egeszsegugyi Szolgaltato Kft.
  - Gyula, Hungary, 5700
    - Synexus Magyarorszag Kft.
  - Hajduszoboszlo, Hungary, 4200
    - Edes Szivunk Egeszsegkozpont Kft.
  - Hatvan, Hungary, 3000
    - BKS Research Kft., Albert Schweitzer Korhaz
  - Kaposvar, Hungary, 7400
    - Somogy Megyei Kaposi Mór Oktató Kórház
  - Kecskemet, Hungary, 6000
    - Jutrix Egeszsegugyi Kft
  - Kistarcsa, Hungary, 2143
    - Pest Megyei Flor Ferenc Korhaz
  - Nyiregyhaza, Hungary, 4400
    - Medifarma-98 Kft.
  - Nyiregyhaza, Hungary, 4400
    - Jósa András Oktatókórház
  - Pecs, Hungary, 7624
    - Pecsi Tudomanyegyetem AOK, I. Belgyogyaszati Klinika
  - Szekesfehervar, Hungary, 8000
    - Mentahaz Maganorvosi Kozpont
  - Szolnok, Hungary, 5000
    - Hetényi Géza Kórház
  - Szombathely, Hungary, 9700
    - Markusovszky Egyetemi Oktatokarhaz
  - Veszprem, Hungary, 8200
    - Dr. Sydo es Tsa Kft
  - Zalaegerszeg, Hungary, 8900
    - Zala Megyei Kórház
- Bacs-kiskun
  - Kecskemet, Bacs-kiskun, Hungary, 6000
    - Bacs-Kiskun Megyei Korhaz
- Baranya
  - Pecs, Baranya, Hungary, 7624
    - Pecsi Tudomanyegyetem AOK, II.
- Csongrad
  - Szeged, Csongrad, Hungary, 6720
    - Szegedi Tudomanyegyetem AOK, I. sz Belgyogyaszati Klinika
- Fejer
  - Szekesfehervar, Fejer, Hungary, 8000
    - Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz
India
- Gujarat
  - Ahmedabad, Gujarat, India, 380007
    - Dr. Jivraj Mehta Smarak Health Foundation, Bakeri Medical Research Centre
  - Ahmedabad, Gujarat, India, 380054
    - Apex Heart Institute (A Unit of TCVS Pvt. Ltd)
  - Ahmedabad, Gujarat, India, 380054
    - SAL Hospital
  - Surat, Gujarat, India, 395 002
    - Apple Hospital
  - Surat, Gujarat, India, 395002
    - Unicare Heart Institute & Research Center
  - Surat, Gujarat, India, 395009
    - BAPS - Pramukh Swami Hospital
  - Vadodara, Gujarat, India, 390022
    - Rhythm Heart Institute
- Maharashtra
  - Kolhapur, Maharashtra, India, 416012
    - Aster Aadhar Hospital (Prerana Hospital Ltd.)
  - Nagpur, Maharashtra, India, 440012
    - Shri Krishna Hrudayalaya and Critical Care Centre
  - Pune, Maharashtra, India, 411 001
    - Jehangir Clinical Development Centre Pvt. Ltd.
- Telangana
  - Hyderabad, Telangana, India, 500063
    - Mediciti Hospitals
- Uttar Pradesh
  - Lucknow, Uttar Pradesh, India, 226003
    - M.V. Hospital and Research Centre
Ireland
- - Dublin, Ireland, 7
    - Mater Misericordiae University Hospital
  - Dublin, Ireland, 8
    - St. James's Hospital
  - Dublin, Ireland, 24
    - The Adelaide & Meath Hospital-Dublin Incorporating The National Children's Hospital
  - Galway, Ireland
    - Health Research Board
  - Galway, Ireland
    - Portiuncula Hospital
- Leinster
  - Dublin, Leinster, Ireland, 9
    - Beaumont Hospital
Israel
- - Ashkelon, Israel, 7830604
    - Barzilai Medical Center
  - Bat Yam, Israel, 5955602
    - Gefen Institute for Research and Cardiac Health
  - Beer Sheva, Israel, 84101
    - The Soroka University Medical Center
  - Beer-Sheva, Israel, 84350
    - Ben Yair Community Clinic - Clalit Health Services
  - Hadera, Israel, 38100
    - Heart Institute, Hillel Yaffe Medical Center
  - Haifa, Israel, 31096
    - Rambam Medical Center
  - Haifa, Israel, 34362
    - Cardiovascular Clinical Research Institute
  - Holon, Israel, 58100
    - Edith Wolfson Medical Center
  - Jerusalem, Israel, 91120
    - Hadassah Ein Kerem Medical Center
  - Jerusalem, Israel, 91004
    - Heart Institute, Bikur Cholim Campus, Shaare Zedek Medical Center
  - Kfar Saba, Israel, 44281
    - Meir Medical Center
  - Kfar-Saba, Israel, 44281
    - Meir Medical Center
  - Nahariya, Israel, 22100
    - Galilee Medical Center, Cardiology Department
  - Nazareth, Israel, 16100
    - E.M.M.S Nazareth Hospital
  - Petach Tikva, Israel, 4958202
    - Sha'aria Clinic, Clalit Health Services
  - Petah Tikva, Israel, 49100
    - Rabin Medical Center
  - Petah Tikva, Israel, 49100
    - Rabin Medical Center, Beilinson Hospital
  - Petah Tikva, Israel, 49100
    - Rabin Medical Center-Beilinson Hospital
  - Raanana, Israel, 43452
    - Shuali Community Clinic, Clalit Health Services
  - Ramat Gan, Israel, 52621
    - Department of Neurology & Sagol Neuroscience Center
  - Rehovot, Israel, 76100
    - Kaplan Medical Center
  - Rehovot, Israel, 76100
    - Heart Institute, Kaplan Medical Center
  - Safed, Israel, 13100
    - Internal Medicine A, Ziv Medical Center
  - Tel Aviv, Israel, 6789140
    - Assuta Medical Center
  - Tel HaShomer, Israel, 5265601
    - The Chaim Sheba Medical Center
  - Tel-Aviv, Israel, 64239
    - Tel Aviv Sourasky Medical Center
Italy
- - Ancona, Italy, 60124
    - I.N.R.C.A. di Ancona Ospedale Geriatrico
  - Belluno, Italy, 32100
    - Ospedale Civile Regionale San Martino, Belluno
  - Cagliari, Italy, 09124
    - Azienda Ospedaliera G. Brotzu
  - Naples, Italy, 80131
    - Divisione di Cardiologia con Utic ed Emodinamica
  - Napoli, Italy, 80131
    - Department of Clinical Medicines and Cardiovascular Sciences, Universita "Federico II" di Napoli
  - Napoli, Italy, 80131
    - Divisione di Cardiologia con Utic ed Emodinamica - AOU Federico II di Napoli
  - Reggio Emilia, Italy, 42123
    - A.O. di Reggio Emilia Arcispedale "S. Maria Nuova"/IRCCS
  - Rimini, Italy, 47923
    - AUSL Della Romagna-Ospedale Infermi
  - Rome, Italy, 00161
    - Policlinico Umberto I di Roma - DAI Malattie Cardiovascolari e Respiratorie
  - Rovigo, Italy, 45100
    - Ospedale Santa Maria della Misericordia Azienda ULSS 18 of Rovigo
  - Salerno, Italy, 84100
    - A.O.U. San Giovanni di Dio e Ruggi d'Aragona U.O.C. UTIC
  - Udine, Italy, 33100
    - Azienda Ospedaliera Universitaria Santa Maria della Misericordia
- Bergamo
  - Treviglio (BG), Bergamo, Italy, 24047
    - A.O. Treviglio e Caravaggio
- CZ
  - Catanzaro, CZ, Italy, 88100
    - AOU Policlinico "Mater Domini" UOC di Medicina Interna
- Lecco
  - Merate, Lecco, Italy, 23807
    - Ospedale S. L. Mandic di Merate
- MI
  - Milano, MI, Italy, 20138
    - IRCCS Centro Cardiologico Fondazione Monzino
- PA
  - Palermo, PA, Italy, 90127
    - AOU Policlinico "P. Giaccone" Dipartimento delle Patologie Emergenti, Unita di Medicina Interna
- PG
  - Perugia, PG, Italy, 06132
    - Ospedale S. Maria della Misericordia Dipartimento di Medicina, Medicina Interna,
- Padova
  - Piove Di Sacco, Padova, Italy, 35028
    - Ospedale Civile Di Piove Di Sacco
- Province OF Lecco
  - Lecco, Province OF Lecco, Italy, 23900
    - Azienda Ospedaliera Della Provincia Di Lecco - Ospedale Manzoni
- RM
  - Roma, RM, Italy, 00161
    - Dept."Medicina lnterna e Specialita Mediche" dell' Universita degli
  - Rome, RM, Italy, 00161
    - Policlinico Umberto I Di Roma
  - Rome, RM, Italy, 00189
    - Azienda Ospedaliera S'Andrea di Roma - UOC Cardiologia
- VR
  - Verona, VR, Italy, 37126
    - AOUI di Verona - Ospedale Civile Maggiore Borgo Trento
- Venezia
  - San Dona Di Paive, Venezia, Italy, 30027
    - Presidioospedaliero di san dona 'di PIAVE
- Verona
  - San Bonifacio, Verona, Italy, 37047
    - Ospedale G. Fracastoro
Korea, Republic of
- - Busan, Korea, Republic of, 49201
    - Dong-A University Hospital
  - Busan, Korea, Republic of, 47392
    - Inje University Busan Paik Hospital
  - Daegu, Korea, Republic of, 42472
    - Daegu Catholic University Medical Center
  - Daejeon, Korea, Republic of, 302-718
    - Konyang University Hospital
  - Daejeon, Korea, Republic of, 34943
    - Daejeon St. Mary's Hospital-The Catholic University of Korea
  - Gwangju, Korea, Republic of, 61469
    - Chonnam National University Hospital
  - Incheon, Korea, Republic of, 21565
    - Gachon University Gil Medical Center
  - Seoul, Korea, Republic of, 138-736
    - Asan Medical Center
  - Seoul, Korea, Republic of, 06273
    - Gangnam Severance Hospital, Yonsei University Health System
  - Seoul, Korea, Republic of, 05355
    - Hallym University Kangdong Sacred Heart Hospital
  - Seoul, Korea, Republic of, 07061
    - SMG-SNU Boramae Medical Center
- Chungcheonbuk-do
  - Cheongju-si, Chungcheonbuk-do, Korea, Republic of, 28644
    - Chungbuk National University Hospital
- Gangwon-do
  - Chuncheon-si, Gangwon-do, Korea, Republic of, 24289
    - Kangwon National University Hospital
  - Wonju-Si, Gangwon-do, Korea, Republic of, 26426
    - Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital
- Gyeonggi-do
  - Goyang-Si, Gyeonggi-do, Korea, Republic of, 10380
    - Inje University Ilsan Paik Hospital
  - Goyang-si, Gyeonggi-do, Korea, Republic of, 10326
    - DongGuk University ilsan Hospital
  - Goyang-si, Gyeonggi-do, Korea, Republic of, 10475
    - Myongji Hospital
  - Seongnam-si, Gyeonggi-do, Korea, Republic of, 13620
    - Seoul National University Bundang Hospital
  - Suwon-si, Gyeonggi-do, Korea, Republic of, 16499
    - Ajou University Hospital
  - Uijeongbu-si, Gyeonggi-do, Korea, Republic of, 11765
    - Uijeongbu St. Mary's Hospital-The Catholic University of Korea
- Incheon
  - Jung-gu, Incheon, Korea, Republic of, 400-711
    - Inha University Hospital
Mexico
- - Aguascalientes, Mexico, 20127
    - Instituto Biomedico De Investigacion A.C.
  - Aguascalientes, Mexico, 20230
    - Centro de Investigación Cardiométabolica de Aguascalientes S.A. de C.V.
  - Aguascalientes, Mexico, 20230
    - Centro Hospitalario Mac, S.A. De C.V. (Emergencies)
  - Aguascalientes, Mexico, 20230
    - Hospital Cardiologica Aguescalientes
  - Chihuahua, Mexico, 31217
    - Investigacion en Salud y Metabolismo S.C
  - Chihuahua, Mexico, 31203
    - Unidad de Investigacion en Salud de Chihuahua S.C.
  - Chihuahua, Mexico, 31215
    - Investigación en Salud y Metabolismo S.C.
  - Chihuahua, Mexico, 31217
    - Consultorio Medico de Especialidad Dr. Demetrio Kosturakis Garcia
  - Distrito Federal, Mexico, 14000
    - Instituto Nacional de Ciencia Medicas y Nutricion Salvador Zubiran
  - Durango, Mexico, 34000
    - Lahoja Asociación para la Investigación y Farmacovigilancia S.C.
  - Durango, Mexico, 34080
    - Cardioprevent, S.C.
  - Queretaro, Mexico, 76000
    - Pharmacology and Clinical Research S.A. de C.V.
  - San Luis Potosi, Mexico, 78200
    - Cardioarritmias e Investigación S.C.
  - San Luis Potosi, Mexico, 78218
    - Hospital Lomas de San Luis Intemacional (Emergencies)
  - San Luis Potosi, Mexico, 78240
    - "Hospital Central ""Dr. Ignacio Morones Prieto"""
  - Veracruz, Mexico, 91910
    - Centro Especializado En Diabetes Y Metabolismo
- Chihuahua
  - Cd. Juarez, Chihuahua, Mexico, 32472
    - Consultorio Dr. Leocadio Gerardo Munoz Beltran
- D F
  - Mexico, D F, Mexico, 11650
    - Centro Especializado en Diabetes, Obesidad y Prevención de Enfermedades Cardiovasculares, S.C.
- DF
  - Mexico, DF, Mexico, 06700
    - Centro de Atencion e Investigacion en Factores de Riesgo Cardiovascular Omega S.C
- Distrito Federal
  - Mexico, Distrito Federal, Mexico, 07760
    - Consultorio de Endocrinologia y Nutriologia
  - Mexico, Distrito Federal, Mexico, 07760
    - Operadora de Hospitales Angeles S.A. de C.V.(Emergencies)
  - Mexico, Distrito Federal, Mexico, 14000
    - Instituto Nacional de Ciencias Médicas y Nutricion "Salvador Zubiran"
- Guerrero
  - Acapulco de Juarez, Guerrero, Mexico, 39670
    - Centro de Investigacion Clinica del Pacifico, S.A. de C.V.
- Hidalgo
  - Pachuca, Hidalgo, Mexico, 42090
    - Investigacion Biomedica Aplicada de Hidalgo S.A. de C.V.
- Jalisco
  - Guadalajara, Jalisco, Mexico, 44160
    - Centro de Investigación Médica Integral S.C.
  - Guadalajara, Jalisco, Mexico, 44670
    - Unidad de Investigacion Clinica y Atencion Medica HEPA S.C.
  - Guadalajara, Jalisco, Mexico, 44340
    - Instituto de Terapeutica Experimental y Clinica (INTEC) Centro Universitario de Ciencias de la Salud
  - Guadalajara, Jalisco, Mexico, 44620
    - Hospital Mexico Americano S.C. (Emergencies)
  - Guadalajara, Jalisco, Mexico, 44657
    - Consultorio Privado del Dr. Gabriel Arturo Ramos Lopez
  - Guadalajara, Jalisco, Mexico, 44670
    - CICEJ Centro de Investigacion Clinica Endocrinologica de Jalisco SC
  - Zapopan, Jalisco, Mexico, 45040
    - Jardines Hospital de Especialidades S.A de C.V
- Morelos
  - Cuernavaca, Morelos, Mexico, 62250
    - Instituto de Diabetes Obesidad y Nutricion, S.C.
  - Cuernavaca, Morelos, Mexico, 62270
    - Hospital Inovamed Cuernavaca (Emergencies)
- Nuevo LEON
  - Monterrey, Nuevo LEON, Mexico, 64460
    - Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
  - Monterrey, Nuevo LEON, Mexico, 64718
    - Global Trial Research Center S.A. de C.V.
  - Monterrey, Nuevo LEON, Mexico, 64000
    - Monterrey International Research Center
  - Monterrey, Nuevo LEON, Mexico, 64000
    - Accelerium S. de R.L. de C.V.
  - Monterrey, Nuevo LEON, Mexico, 64000
    - Hospital y Clinica OCA, S.A. de C.V.
  - Monterrey, Nuevo LEON, Mexico, 64060
    - Cardiolink Clin Trials, S.C.
  - Monterrey, Nuevo LEON, Mexico, 64460
    - Hospital Universitario De Monterrey- "Doctor Jose Eleuterio Gonzalez"
  - Monterrey, Nuevo LEON, Mexico, 64710
    - CRI Centro Regiomontano de Investigacion SC
  - San Pedro Garza Garcia, Nuevo LEON, Mexico, 66278
    - Fundacion Santos y de la Garza Evia I.B.P. (Centro Medico Zambrano Hellion)
- Queretaro
  - San Juan del Rio, Queretaro, Mexico, 76800
    - Centro Integral Medico SJR S.C
- Sinaloa
  - Culiacan, Sinaloa, Mexico, 80020
    - Centro Para El Desarrollo de La Medicina Y de Asistencia Medica Especializada S.C.
  - Culiacan, Sinaloa, Mexico, 80020
    - Hospital Angeles Culiacan (Emergencies Only)
- Tamaulipas
  - Tampico, Tamaulipas, Mexico, 89000
    - Centro de Estudios de Investigación Metabólicos y Cardiovasculares S.C.
- Veracruz
  - Xalapa, Veracruz, Mexico, 91020
    - Centro De Especialidades Medicas Del Estado De Veracruz
Netherlands
- - Alkmaar, Netherlands, 1815 JD
    - Noordwest Ziekenhuisgroep
  - Almere, Netherlands, 1311 RL
    - EB FlevoResearch
  - Amersfoort, Netherlands, 3813 TZ
    - Meander Medisch Centrum
  - Amersfoort, Netherlands, 3813 TZ
    - Meander Medical Center
  - Amstelveen, Netherlands, 1186 AM
    - Amstelland Hospital
  - Amsterdam, Netherlands, 1105 AZ
    - Academic Medical Center
  - Amsterdam, Netherlands, 1091 AC
    - Onze Lieve Vrouwe Gasthuis
  - Amsterdam, Netherlands, 1034 CS
    - BovenIJ Ziekenhuis
  - Amsterdam, Netherlands, 1061 AE
    - OLVG, locatie West
  - Amsterdam, Netherlands, 1081HV
    - VU University Medical Center
  - Apeldoorn, Netherlands, 7334 DZ
    - Gelre Hospitals
  - Beverwijk, Netherlands, 1942 LE
    - Rode Kruis Ziekenhuis
  - Blaricum, Netherlands, 1261 AN
    - Tergooi Ziekenhuis
  - Breda, Netherlands, 4818 CK
    - Amphia Ziekenhuis
  - Breda, Netherlands, 4811 SW
    - Andro Medical Research B.V.
  - Delft, Netherlands, 2625 AD
    - Reinier de Graaf Ziekenhuis
  - Den Haag, Netherlands, 2545 CH
    - HagaZiekenhuis
  - Den Haag, Netherlands, 2526 HW
    - Hedramed
  - Den Haag, Netherlands, 2526HW
    - Hedramed
  - Den Haag, Netherlands, 2597 AX
    - HMC (Haaglanden Medisch Centrum) Bronovo
  - Deventer, Netherlands, 7416SE
    - Deventer Ziekenhuis
  - Dirksland, Netherlands, 3247 BW
    - Van Weel Bethesda Hospital
  - Doetinchem, Netherlands, 7009 BL
    - Slingeland Ziekenhuis
  - Dordrecht, Netherlands, 3318 AT
    - Albert Schweitzer Hospital
  - Ede, Netherlands, 6716 RP
    - Ziekenhuis Gelderse Vallei
  - Eindhoven, Netherlands, 5611 NV
    - Andromed Eindhoven
  - Eindhoven, Netherlands, 5623 EJ
    - Heartcentre Catharina Hospital
  - Enschede, Netherlands, 7512 KZ
    - Medisch Spectrum Twente
  - Gorinchem, Netherlands, 4204 AA
    - Beatrix Ziekenhuis
  - Gouda, Netherlands, 2803 HH
    - Groene Hart Ziekenhuis
  - Groningen, Netherlands, 9713 GZ
    - University Medical Center Groningen
  - Groningen, Netherlands, 9728 NT
    - Martini Ziekenhuis
  - Haarlem, Netherlands, 2035 RC
    - Spaarne Gasthuis
  - Harderwijk, Netherlands, 3844 DG
    - St. Jansdal Ziekenhuis
  - Heerlen, Netherlands, 6419 PC
    - Zuyderland Medisch Centrum
  - Heerlen, Netherlands, 6419PC
    - Zuyderland
  - Hoogeveen, Netherlands, 7909 AA
    - Treant Zorggroep, location Bethesda
  - Hoorn, Netherlands, 1624 NP
    - Vascular Research Centre
  - Kloosterhaar, Netherlands, 7694 AC
    - Quality Care Research
  - Leeuwarden, Netherlands, 8934 AD
    - Medisch Centrum Leeuwarden
  - Leiden, Netherlands, 2333 ZA
    - Leiden University Medical Center
  - Leiden, Netherlands, 2334 CK
    - Alrijne Ziekenhuis
  - Leiderdorp, Netherlands, 2353 GA
    - Alrijne Ziekenhuis
  - Maarssen, Netherlands, 3607 KN
    - GCM Maarssenbroek
  - Maastricht, Netherlands, 6229 HX
    - Maastricht University Medical Center
  - Meppel, Netherlands, 7943 KA
    - Isala Diaconessenhuis
  - Nieuwegein, Netherlands, 3435 CM
    - St Antonius hospital
  - Nijmegen, Netherlands, 6532 SZ
    - Canisius Wilhelmina Ziekenhuis
  - Nijmegen, Netherlands, 6525 GA
    - Radboud University Nijmegen Medical Centre
  - Purmerend, Netherlands, 1441 RN
    - Waterland Hospital
  - Rotterdam, Netherlands, 3083 AN
    - Ikazia Ziekenhuis
  - Rotterdam, Netherlands, 3021 HC
    - Andro Medical Research B.V
  - Rotterdam, Netherlands, 3039 BD
    - Rotterdam Research Institute
  - Rotterdam, Netherlands, 3045 PM
    - St. Fransiscus Gasthuis
  - Sneek, Netherlands, 8601 ZR
    - D&A Research and Genetics
  - Tiel, Netherlands, 4002 WP
    - Ziekenhuis Rivierenland
  - Tilburg, Netherlands, 5022 GC
    - St. Elisabeth Ziekenhuis
  - Tilburg, Netherlands, 5022 GC
    - Elisabeth-TweeSteden Ziekenhuis (previously named St. Elisabeth Ziekenhuis)
  - Tilburg, Netherlands, 5042 AD
    - Elisabeth TweeSteden Ziekenhuis (ETZ)
  - Uden, Netherlands, 5406 PT
    - Bernhoven Ziekenhuis
  - Utrecht, Netherlands, 3584 CX
    - University Medical Center Utrecht
  - Utrecht, Netherlands, 3511 NH
    - EB Utrecht
  - Utrecht, Netherlands, 3584 CX
    - Universitair Medisch Centrum (UMC) Utrecht - Locatie AZU
  - Veldhoven, Netherlands, 5504 DB
    - Maxima Medisch Centrum
  - Venlo, Netherlands, 5912 BL
    - VieCuri Medisch Centrum
  - Waalwijk, Netherlands, 5141 BM
    - Twee Steden Ziekenhuis
  - Zwijndrecht, Netherlands, 3331 LZ
    - Albert Schweitzer Hospital
- Friesland
  - Heerenveen, Friesland, Netherlands, 8441 PW
    - Tjongerschans Ziekenhuis
- Limburg
  - Sittard-Geleen, Limburg, Netherlands, 6162 BG
    - Zuyderland MC
- Overijssel
  - Zwolle, Overijssel, Netherlands, 8025 AB
    - Isala
- Zuid-holland
  - Rotterdam, Zuid-holland, Netherlands, 3045 PM
    - St. Franciscus Gasthuis
  - Zoetermeer, Zuid-holland, Netherlands, 2725 NA
    - Het Lange Land Ziekenhuis
New Zealand
- - Auckland, New Zealand, 1023
    - Auckland City Hospital
  - Christchurch, New Zealand, 8011
    - Lipid and Diabetes Research Group
  - Christchurch, New Zealand, 8011
    - Southern Clinical Trials Shirley Ltd
  - Christchurch, New Zealand, 8041
    - Southern Clinical Trials Riccarton
  - Dunedin, New Zealand, 9012
    - RMC Medical Research Ltd.
  - New Plymouth, New Zealand, 4310
    - Taranaki Base Hospital
  - Rotorua, New Zealand, 3010
    - Rotorua Hospital
  - Tauranga, New Zealand, 3112 New Zealand
    - Clinical Horizons NZ Ltd.
  - Tauranga, New Zealand, 3112
    - Clinical Trials Unit,Bay of Plenty(BOP) Clinicla School
  - Tauranga, New Zealand, 3118
    - Papamoa Pines Medical Centre
  - Tauranga, New Zealand, 3144
    - Clinical Horizons NZ Ltd
  - Wellington, New Zealand, 6021
    - Wellington Hospital
- Auckland
  - Grafton, Auckland, New Zealand, 1010
    - Optimal Clinical Trials
  - Henderson, Auckland, New Zealand, 0612
    - Henderson Medical Centre
  - Otahuhu, Auckland, New Zealand, 1640
    - Middlemore Hospital
  - Takapuna, Auckland, New Zealand, 0622
    - North Shore Hospital
- Hastings
  - Frimley, Hastings, New Zealand, 4120
    - Hawke's Bay Hospital
Poland
- - Gdynia, Poland, 81-472
    - Marek Piepiorka Gabinet Kardiologiczno - lnternistyczny
  - Krakow, Poland, 30-053
    - Nzoz Gall-Med
  - Krakow, Poland, 31-567
    - NZOZ Centrum Zdrowia i Profilaktyki Dabie Sp. z.o.o.
  - Lublin, Poland, 20-857
    - "TWOJA PRZYCHODNIA" Sp. Z o.o
  - Opole, Poland, 45-706
    - Medicus w Opolu Sp z o. o.
  - Poznan, Poland, 60-592
    - Centrum Zdrowia Metabolicznego Pawel Bogdanski
  - Ruda Slaska, Poland, 41-709
    - NZOZ Przychodnia Specjalistyczna Andrzej wittek Henryk Rudzki S.C.
  - Staszow, Poland, 28-200
    - KO-MED Centra Kliniczne Staszow
  - Warszawa, Poland, 01-192
    - Synexus Polska Sp. z o.o. Oddzial w Warszawie
  - Warszawa, Poland, 02-097
    - Centrum Medyczne Warszawskiego Uniwersytetu Medycznego Sp. z o.o
  - Warszawa, Poland, 04-628
    - Instytut Kardiologii im. Prymasa Tysiaclecia Stefana Kardynala Wyszynskiego Klinika Kardiologii
  - Wroclaw, Poland, 50-088
    - Synexus Polska Sp. Z O.O. Oddzial We Wroclawiu
  - Wroclaw, Poland, 50-306
    - Centrum Opieki Diabetologiczno-Endokrynologicznej i Ginekologiczno-Polozniczej
  - Wroclaw, Poland, 53-301
    - Dobrostan Michal Bogacki
- Dolnoslaskie
  - Jelenia Gora, Dolnoslaskie, Poland, 58-506
    - Jeleniogorskie Centrum Chorob Serca, Przychodnia Kardiologiczna, Poradnia Kardiologiczna
  - Wroclaw, Dolnoslaskie, Poland, 51-314
    - Zdrowie S.C. Agnieszka I Donald Drożdż
  - Zarow, Dolnoslaskie, Poland, 58-130
    - Halina Serafin NZOZ Centrum Medyczne SERAFIN-MED
- Kujawsko-pomorskie
  - Bydgoszcz, Kujawsko-pomorskie, Poland, 85-079
    - NZOZ Vitamed
  - Bydgoszcz, Kujawsko-pomorskie, Poland, 85-231
    - NZOZ Centrum Medyczne KERmed
  - Grudziadz, Kujawsko-pomorskie, Poland, 86-300
    - Specjalistyczna Praktyka Lekarska Piotr Kubalski
  - Wloclawek, Kujawsko-pomorskie, Poland, 87-800
    - Specjalistyczne Gabinety Lekarskie "Medicor Plus" - Jerzy Kopaczewski
- Lodzkie
  - Lodz, Lodzkie, Poland, 90-132
    - Gabinet Lekarski Malgorzata Saryusz-Wolska
  - Lodz, Lodzkie, Poland, 90-368
    - Specjalistyczny Osrodek Medycyny Wieku Dojrzalego Sp. z o.o. Jednostka 02
  - Lodz, Lodzkie, Poland, 91-490
    - "Prywatny Gabinet Kardiologiczny" Dr N.Med. Maciej Kosmider
  - Lodz, Lodzkie, Poland, 92-003
    - Niepubliczny Zaklad Opieki Zdrowotnej CEREO-MED Sp. z o.o.
  - Piotrkow Trybunalski, Lodzkie, Poland, 97-300
    - Prywatny Gabinet Lekarski Dr n. med. Michal Ogorek
  - Skierniewice, Lodzkie, Poland, 96-100
    - Centrum Medyczne Ogrodowa sp. z o.o.
- Lubelskie
  - Lublin, Lubelskie, Poland, 20-045
    - Clinical Best Solutions
  - Lublin, Lubelskie, Poland, 20-091
    - Optimamed Specjalistyczne Gabinety Lekarskie
  - Lublin, Lubelskie, Poland, 20-362
    - KO-MED Centra Kliniczne Lublin II
  - Pulawy, Lubelskie, Poland, 24-100
    - KO-MED Centra Kliniczne Pulawy
  - Zamosc, Lubelskie, Poland, 22-400
    - KO-MED Centra Kliniczne Zamosc
- Malopolskie
  - Krakow, Malopolskie, Poland, 30-015
    - Landa Specjalistyczne Gabinety Lekarskie
  - Krakow, Malopolskie, Poland, 31- 202
    - Krakowski Szpital Specjalistyczny im. Jana Pawla II
  - Krakow, Malopolskie, Poland, 31-121
    - Szpital Specjalistyczny im. J. Dietla w Krakowie, Oddzial Kardiologii
  - Krakow, Malopolskie, Poland, 31-216
    - Centrum Medyczne Zdrowa J. Trebacz, W. Zajdel Spolka Jawna
  - Krakow, Malopolskie, Poland, 31-315
    - Centrum Medyczne A-Z Clinic
  - Krakow, Malopolskie, Poland, 31-501
    - Krakowskie Centrum Medyczne Sp. z o.o.
  - Krakow, Malopolskie, Poland, 31-501
    - Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie,
  - Krakow, Malopolskie, Poland, 31-531
    - Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki W Krakowie, Ambulatoria
  - Krakow, Malopolskie, Poland, 31-567
    - NZOZ Centrum Zdrowia i Profilaktyki Dabie Sp. z.o.o.
  - Krakow, Malopolskie, Poland, 31-637
    - Niepubliczny Zaklad Opieki Zdrowotnej Centrum Medyczne ProMiMed sp z o.o., sp.k.
  - Myslenice, Malopolskie, Poland, 32-400
    - NeuroCor Banaszkiewicz, Kulaga, Ostrowska, Tomaszewski lekarze spolka partnerska
  - Nowy Targ, Malopolskie, Poland, 34-400
    - INTERCARD Sp. z. o. o. Centrum Kardiologii Inwazyjnej, Elektroterapii i Angiologii w Nowym Targu
  - Oswiecim, Malopolskie, Poland, 32-600
    - Medicome Sp. z o.o.
  - Tarnow, Malopolskie, Poland, 33-100
    - Centrum Szybkiej Diagnostyki Kardiologicznej Kardiomed M. Zabowka E. Zabowka
  - Tarnow, Malopolskie, Poland, 33-100
    - Specjalistyczny Gabinet Lekarski Internistyczno-Kardiologiczny Boguslaw Derlaga
- Mazowieckie
  - Katowice, Mazowieckie, Poland, 40-040
    - Synexus Polska Sp. Z O.O. Oddzial W Katowicach
  - Plock, Mazowieckie, Poland, 09-402
    - Niepubliczny Zaklad Opieki Zdrowotnej Specjalistyczna Przychodnia Lekarska "MEDIKARD"
  - Warszawa, Mazowieckie, Poland, 04-730
    - Specjalistyczny Osrodek Medycyny Wieku Dojrzalego sp. z o.o.
  - Warszawa, Mazowieckie, Poland, 01-875
    - Centrum Medyczne Piaski Filia Nr 9
  - Warszawa, Mazowieckie, Poland, 02-637
    - Instytut Kardiologii im. Prymasa Tysiaclecia Stefana Kardynala Wyszynskiego
  - Warszawa, Mazowieckie, Poland, 04-141
    - Wojskowy Instytut Medyczny,Centralny Szpital Kliniczny Ministerstwa Obronty Narodowej
  - Warszawa, Mazowieckie, Poland, 04-628
    - Instytut Kardiologii im
- Podkarpackie
  - Brzozow, Podkarpackie, Poland, 36-200
    - Szpital Specjalistyczny w Brzozowie, Podkarpacki Osrodek Onkologiczny im. Ks. B. Markiewicza Oddzial
  - Krosno, Podkarpackie, Poland, 38400
    - INTERCARD Sp. z o.o. Centrum Kardiologii Inwazyjnej, Elektroterapii i Angiologii w Krosnie
  - Rzeszow, Podkarpackie, Poland, 35205
    - EMED Centrum Uslug Medycznych Ewa Smialek
- Podlaskie
  - Bialystok, Podlaskie, Poland, 15-351
    - "OSTEO-MEDIC" s.c. Artur Racewicz, Jerzy Supronik
  - Bialystok, Podlaskie, Poland, 15-875
    - Podlaski Osrodek Kardiologii Janusz Korecki
- Pomorskie
  - Gdansk, Pomorskie, Poland, 80-382
    - Synexus Polska Sp. z o.o. Oddzial w Gdansku
  - Gdansk, Pomorskie, Poland, 80-542
    - Niepubliczny Zaklad Opieki Zdrowotnej Gdanskie Centrum Zdrowia, Poradnia Kardiologiczna
  - Gdansk, Pomorskie, Poland, 80-546
    - Centrum Badan Klinicznych Pi-House, Poradnia Diabetologiczna
  - Gdynia, Pomorskie, Poland, 81-338
    - Medica Pro Familia Sp. z o.o. Spolka Komandytowo Akcyjna, Oddzial w Gdyni
  - Gdynia, Pomorskie, Poland, 81-384
    - Synexus Polska Sp. z o.o. Oddzial w Gdyni
  - Gdynia, Pomorskie, Poland, 81-423
    - NZOZ "PRO CORDIS" Sopockie Centrum Badan Kardiologicznych
  - Gdynia, Pomorskie, Poland, 81-472
    - Gabinet Kardiologiczno - lnternistyczny
  - Sopot, Pomorskie, Poland, 81-756
    - Centrum Medyczne "SOPMED" Sp. z o.o.
  - Starogard Gdanski, Pomorskie, Poland, 83-200
    - Indywidualna Specjalistyczna Praktyka Lekarska Malgorzata Biedrzycka
- Slaskie
  - Bytom, Slaskie, Poland, 41-902
    - Samodzielny Publiczny Zaklad Opieki Zdrowotnej Wojewodzki Szpital Specjalistyczny Nr 4 w Bytomiu
  - Katowice, Slaskie, Poland, 40-083
    - Bogna Gabrylewicz Andrzej Ochala Unimed s.c.
  - Katowice, Slaskie, Poland, 40-648
    - Pro Familia Altera Poradnia Wielospecjalistyczna
  - Katowice, Slaskie, Poland, 40-752
    - NZOZ Terapia Optima
  - Ruda Slaska, Slaskie, Poland, 41-709
    - Przychodnia Specjalistyczna Samodzielny Publiczny ZOZ w Rudzie Slaskiej,
  - Wola, Slaskie, Poland, 43-225
    - NZOZ "Medyk"Sp. z o. o.
- Swietokrzyskie
  - Kielce, Swietokrzyskie, Poland, 25-315
    - Prywatny Gabinet Lekarski Marianna Janion
- WOJ Mazowieckie
  - Warszawa, WOJ Mazowieckie, Poland, 01-518
    - Centrum Medyczne AMED
- Warminsko-mazurskie
  - Elblag, Warminsko-mazurskie, Poland, 82-300
    - Wojewodzki Szpital Zespolony w Elblagu, Oddzial Kardiologiczny z Pododdzialem Kardiologii Inwazyjnej
  - Ostroda, Warminsko-mazurskie, Poland, 14-100
    - Specjalistyczny Osrodek Leczniczo-Badawczy Zbigniew Zegota
- Wielkopolskie
  - Poznan, Wielkopolskie, Poland, 60-702
    - Synexus Polska Sp. z o.o Oddzial w Poznaniu
  - Poznan, Wielkopolskie, Poland, 61-006
    - Nzoz "Twoja Przychodnia"
- Wojewodztwo Lodzkie
  - Lodz, Wojewodztwo Lodzkie, Poland, 92-213
    - SPZOZ Centralny Szpital Kliniczny Uniwersytetu Medycznego w Lodzi 251 Pomorska
Puerto Rico
- - Anasco, Puerto Rico, 00610
    - The Office of Roberto J. Ayala-Rios, MD - Research Center and Private Practice (DMRA LLC)
  - Ponce, Puerto Rico, 00717
    - Cardiometabolic Research Center, Inc.
  - Ponce, Puerto Rico, 00717
    - Endocrine Lipid Diabetes Research Institute
  - San Juan, Puerto Rico, 00917
    - Consultorio Medico Figueroa
  - San Juan, Puerto Rico, 00917
    - Pradnet Inc.
  - San Juan, Puerto Rico, 00920
    - Altamira Family Medicine And Research Institute
  - San Juan, Puerto Rico, 00926-2832
    - Miguel Sosa-Padilla, MD-Private Practice
  - San Juan, Puerto Rico, 00935
    - Centro de Diabetes para Puerto Rico
Romania
- - Baia Mare, Romania, 430032
    - Euromedica Hospital
  - Braila, Romania, 810249
    - Spitalul Clinic Judetean De Urgenta Braila(Braila County Clincal Emergency Hospital)
  - Brasov, Romania, 500209
    - S.C. Polimed Dacia S.R.L.
  - Brasov, Romania, 500283
    - Centrul Medical de Diagnostic si Tratament Ambulator NEOMED
  - Bucharest, Romania, 010192
    - Data Plus Medical Clinic
  - Bucharest, Romania, 020045
    - "Prof. Dr. N.C. Paulescu" National Institute of Diabetes, Nutrition and Metabolic Diseases,
  - Bucharest, Romania, 061118
    - Med Plus SRL (Med Plus Ltd.)
  - Bucharest, Romania, 20614
    - S.C. Centrul Medical "Sanatatea Ta" S.R.L.
  - Bucuresti, Romania, 010825
    - Spitalul Universitar De Urgenta Militar Central, Dr. Carol Davila
  - Bucuresti, Romania, 020125
    - Spitalul Clinic Colentina, Departament Cardiologie
  - Bucuresti, Romania, 021611
    - SC Clinica Medicala Synexus SRL, Medicina Interna
  - Bucuresti, Romania, 021967
    - SC Centrul Medical Policlinico Di Monza SRL, Cardiologie
  - Bucuresti, Romania, 030463
    - SC Policlinica CCBR SRL
  - Cluj, Romania, 400006
    - Spitalul Clinic Judetean de Urgenta Cluj-Napoca, Diabet Zaharat, Nutritie si Boli Metabolice
  - Galati, Romania, 800098
    - Dr. Mistodie Cristina Victoria MD, Office of
  - Galati, Romania, 800291
    - S.C. Diamed Obesity S.R.L.
  - Satu Mare, Romania, 440055
    - County Emergency Hospital Satu Mare Diabetes, Nutrition And Metabolic Diseases Department
  - Sibiu, Romania, 550245
    - County Clinical Emergency Hospital Sibiu
  - Targu Mures, Romania, 540124
    - Cardio Med SRL
  - Timisoara, Romania, 300456
    - Centrul Medical Dr. Negrisanu SRL, Diabet Zaharat, Nutritie si Boli Metabolice
- Arges
  - Pitesti, Arges, Romania, 110084
    - Pitesti-Arges County Emergency Hospital
- Bihor
  - Oradea, Bihor, Romania, 410032
    - Medical Practice SRL
  - Oradea, Bihor, Romania, 410169
    - County Clinical Emergency Hospital Oradea
- Hunedoara
  - Deva, Hunedoara, Romania, 330084
    - County Emergency Hospital Deva
- JUD. Timis
  - Timisoara, JUD. Timis, Romania, 300125
    - Centrul Medical Sf. Stefan
- Maramures
  - Baia Mare, Maramures, Romania, 430130
    - Dr. Pop Calin Florin - Cabinet Cardiologie
- Mures
  - Targu Mures, Mures, Romania, 540143
    - Podoleanu G. Cristian-Gheorghe-Calin - Cardiology Medical Practice
- Prahova
  - Ploiesti, Prahova, Romania, 100163
    - Diabmed Dr. Popescu Alexandrina SRL, Diabet, Nutritie, Boli Metabolice
  - Ploiesti, Prahova, Romania, 100342
    - Dr. Busegeanu Mihaela Private Practice
- Timis
  - Timisoara, Timis, Romania, 300310
    - Institute of Cardiovascular Diseases Timisoara
Russian Federation
- - Chelyabinsk, Russian Federation, 454047
    - Municipal Budgetary State Healthcare Institution "City Clinical Hospital #6"
  - Chelyabinsk, Russian Federation, 454092
    - Non-State Institution of Healthcare "Railway Clinical Hospital at station Chelyabinsk of open
  - Chelyabinsk, Russian Federation, 454136
    - State Budgetary Healthcare Institution "Region Clinical Hospital #3"
  - Ekaterinburg, Russian Federation, 620039
    - Municipal Autonomous Institution "City Clinical Hospital #14"
  - Ivanovo, Russian Federation, 153012
    - Regional Budgetary Healthcare Institution "Cardiology Dispensary"
  - Kaluga, Russian Federation, 428007
    - State Budgetary Institution of Healthcare of Kaluga Region "Kaluga Regional Hospital"
  - Kazan, Russian Federation, 420012
    - Federal State Budgetary Educational Institution of Higher Education "Kazan State Medical University"
  - Kazan, Russian Federation, 420064
    - State Autonomous Healthcare Institution
  - Kemerovo, Russian Federation, 650000
    - "SAHI of Kemerovo ""Regional Clinical Hospital of Emergency Medical Care n.a. M.A Podgorbunsky """
  - Kemerovo, Russian Federation, 650000
    - Municipal Budgetary Institution of Healthcare
  - Kemerovo, Russian Federation, 650002
    - Federal state budgetary institution Research institute of complex problems
  - Kemerovo, Russian Federation, 650099
    - FSHI "Medical and Sanitary Unit of the Ministry of Internal Affairs of Russia across Kemerovo region
  - Kirov, Russian Federation, 610014
    - Kirov Regional State Budgetary Healthcare Institution "Kirov City Clinical Hospital #1"
  - Kursk, Russian Federation, 305035
    - Regional Budgetary Healthcare Institution "Kursk City Clinical Emergency Hospital"
  - Moscow, Russian Federation, 109388
    - Non-State Institution of Healthcare "Central Clinical Hospital #6 OAO "RZhD"
  - Moscow, Russian Federation, 109990
    - Federal State Budgetary Institution "State Research Center for Preventive Medicine" of the Ministry
  - Moscow, Russian Federation, 111539
    - SBHI of Moscow city "City Clinical Hospital #15 n.a. O.M. Filatova"
  - Moscow, Russian Federation, 119435
    - SBEI of HPE I. M. Sechenov First Moscow State Medical University, UKB #2
  - Moscow, Russian Federation, 121309
    - State Healthcare Institution "City Clinical Hospital #51 of Healthcare Department of Moscow City"
  - Moscow, Russian Federation, 121359
    - Federal State Budgetary Institution "Central Clinical Hospital with Polyclinic"
  - Moscow, Russian Federation, 121552
    - Federal State Budgetary Institution "Russian Cardiology Research And Production Complex" Of Ministry
  - Moscow, Russian Federation, 121552
    - Russian Cardiology Research And Production Complex of Ministry of Health of Russian Federation
  - Moscow, Russian Federation, 125284
    - Moscow State Healthcare Institution "City clinical hospital n.a. S.P.Botkin"
  - Moscow, Russian Federation, 127644
    - SBIH "City Clinical Hospital #81 Departments of Healthcare of Moscow"
  - Moscow, Russian Federation, 129090
    - Federal State Budget Institution "Out-patient Clinic #3" of Russian Federation,
  - Murmansk, Russian Federation, 183047
    - State Regional Budgetary Healthcare Institution
  - Nizhniy Novgorod, Russian Federation, 603076
    - State Budgetary Healthcare Institution of Nizhegorodskaya Region
  - Novosibirsk, Russian Federation, 630089
    - Federal State Budgetary Institution "Research Institute of Therapy and Preventive Medicine" of
  - Novosibirsk, Russian Federation, 630091
    - SBRIHPE "Novosibirsk State Medical University" of MHSD of RF
  - Novosibirsk, Russian Federation, 630099
    - "Reafan" LLC
  - Novosibirsk, Russian Federation, 630102
    - "SBHI of Novosibirsk ""City Clinical Hospital of Emergency Medical Care # 2"""
  - Novosibirsk, Russian Federation, 630102
    - Municipal Budgetary Institution of Healthcare of Novosibirsk
  - Novosibirsk, Russian Federation, 630102
    - State Budgetary Institution of Healthcare of Novosibirsk region City Clinical Hospital of Emergency
  - Penza, Russian Federation, 440026
    - State Budgetary Institution of Healthcare"Penzenskaya Regional clinical hospital n.a N.N Burdenko"
  - Pushkin, Russian Federation, 196601
    - SBHI of Saint-Petersburg "City Hospital # 38 n.a. N.A. Semashko"
  - Rostov-on-Don, Russian Federation, 344022
    - Federal State Budgetary Educational Institution of Higher Education
  - Rostov-on-Don, Russian Federation, 344022
    - State Budgetary Educational Institution of Higher Professional Education
  - Rostov-on-Don, Russian Federation, 344068
    - State Budgetary Educational Institution of Higher Professional Education
  - Saint Petersburg, Russian Federation, 197341
    - Federal State Budgetary Institution
  - Saint-Petersburg, Russian Federation, 191186
    - Limited Liability Company International Medical Centre SOGAZ
  - Saint-Petersburg, Russian Federation, 192148
    - Saint-Petersburg State Budgetary Institution of Healthcare "City Hospital #23"
  - Saint-Petersburg, Russian Federation, 193312
    - Saint-Petersburg State Budgetary Healthcare Institution "City Alexandrovskaya Hospital"
  - Saint-Petersburg, Russian Federation, 194017
    - Federal state budget institution of healthcare Saint-Petersburg clinical hospital of Russian Academy
  - Saint-Petersburg, Russian Federation, 194354
    - Limited Liability Company "Reavita"
  - Saint-Petersburg, Russian Federation, 196084
    - "Limited Liability Company ""Institute of Medical Research"""
  - Saint-Petersburg, Russian Federation, 196084
    - Limited Liability Company "Institute of Medical research"
  - Saint-Petersburg, Russian Federation, 196084
    - LLC "Institution of medical studies"
  - Saint-Petersburg, Russian Federation, 196601
    - City Hospital # 38 n.a. Semashko
  - Saint-Petersburg, Russian Federation, 197022
    - SBEI of HPE "First Pavlov State Medical University of St. Petersburg" of the MoH of the RF
  - Saint-Petersburg, Russian Federation, 197110
    - Federal State Budgetary Institution "Advisory Diagnostic Center and Polyclinic"
  - Saint-Petersburg, Russian Federation, 198205
    - Saint-Petersburg State Budgetary Healthcare Institution "City Hospital #15"
  - Samara, Russian Federation, 443070
    - State Budgetary Healthcare Institution "Samara Regional Clinical Cardiology Dispensary"
  - Saratov, Russian Federation, 410039
    - MHI "City Clinical Hospital #12" of the Healthcare Committee
  - Saratov, Russian Federation, 410053
    - State Institution of Healthcare "Regional Clinical Hospital"
  - Smolensk, Russian Federation, 214019
    - State Budget Educational Institution of Higher Professional Education
  - St. Petersburg, Russian Federation, 197022
    - Federal State Budgetary Educational Institution of Higher Education
  - Tomsk, Russian Federation, 634009
    - Tyumen Cardiology Research Center-branch of the Tomsk NRMC
  - Tomsk, Russian Federation, 634050
    - GBOU VPO Siberian State Medical University Ministry of Healthcare of the Russian Federation
  - Tomsk, Russian Federation, 634050
    - State Budgetary Educational Institution of Highest Professional Education "Siberian State Medical
  - Tyumen, Russian Federation, 625000
    - State Autonomous Institution of Healthcare of the Tyumen region Tyumen Institute of Therapy
  - Tyumen, Russian Federation, 625026
    - Affiliate of the Federal State Budgetary Institution Scientific Research Institute of Cardiology
  - Yaroslavl, Russian Federation, 150003
    - State Autonomous Healthcare Institution Of Yaroslavl Region
  - Yaroslavl, Russian Federation, 150010
    - FSBEI of HE "Yaroslavl State Medical University" MH of the Russian Federation
  - Yaroslavl, Russian Federation, 150023
    - State Budgetary Healthcare Institution of Yaroslavl Region "Clinical Hospital No. 10"
  - Yaroslavl, Russian Federation, 150030
    - State Healthcare Institution of Yaroslavl Region "Clinical Hospital #8"
- Krasnodar Region
  - Krasnodar, Krasnodar Region, Russian Federation, 350086
    - State Budgetary Healthcare Institution "Research Institution - Regional Clinical Hospital #1
- Moscow Region
  - Lubertsy, Moscow Region, Russian Federation, 140006
    - State Budgetary Healthcare Institution of Moscow Region "Lubertsy Regional Hospital #2"
  - Troitsk, Moscow Region, Russian Federation, 142190
    - Federal State Budgetary Institution of Healthcare Hospital of Russian Academy of Sciences
- Ryazan Region
  - Ryazan, Ryazan Region, Russian Federation, 390039
    - State Budgetary Institution "Ryazan Regional Clinical Hospital"
- Sestroretsk
  - Saint-Petersburg, Sestroretsk, Russian Federation, 197706
    - Saint Petersburg State Budgetary Institution of Healthcare Municipal hospital
- Tatarstan Republic
  - Kazan, Tatarstan Republic, Russian Federation, 420033
    - FSBEI of HE Kazan State Medical University on the base of SBHI Clinical Hospital No.2
  - Kazan, Tatarstan Republic, Russian Federation, 420033
    - SBEI of HPE Kazan State Medical University on the base of SBHI Clinical Hospital No.2
Slovakia
- - Banska Bystrica, Slovakia, 975 17
    - Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica
  - Banska Bystrica, Slovakia, 974 01
    - Stredoslovensky ustav srdcovych a cievnych chorob a.s.
  - Bardejov, Slovakia, 08501
    - Alian s.r.o., kardiologicka ambulancia
  - Bratislava, Slovakia, 811 08
    - METABOL KLINIK s. r.o., Ambulancia pre diabetologiu, poruchy latkovej premeny a vyzivy
  - Bratislava, Slovakia, 81369
    - Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto, l.intema klinika
  - Bratislava, Slovakia, 81369
    - Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto, l.interna klinika
  - Bratislava, Slovakia, 81369
    - Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto
  - Bratislava, Slovakia, 826 06
    - UN Bratislava, Nemocnica Ruzinov, V. interna klinika LFUK a UN Bratislava
  - Bratislava, Slovakia, 83101
    - Kardiovaskularne Centrum S.R.O.
  - Bratislava, Slovakia, 83101
    - Metabolicke centrum MUDr. Katariny Raslovej, s.r.o.
  - Bratislava, Slovakia, 833 48
    - Narodny ustav srdcovych a cievnych chorob, a.s.
  - Bratislava, Slovakia, 83305
    - Univerzitna nemocnica Bratislava
  - Bratislava, Slovakia, 83348
    - Narodny ustav srdcovych a cievnych chorob, a.s.
  - Bratislava, Slovakia, 84108
    - KARDIO-SANUS spol., s.r.o.
  - Bratislava, Slovakia, 851 07
    - UN Bratislava Nemocnica Sv. Cyrila a Metoda, kardiologicka ambulancia 1
  - Bratislava, Slovakia, 85101
    - VERIA, s.r.o. -Kardiologicka ambulancia
  - Dolny Kubin, Slovakia, 02601
    - Endiamed s.r.o. Nestatna diabetologicka a endokrinologicka ambulancia
  - Dolny Kubin, Slovakia, 02601
    - JM-Interna s.r.o., interna ambulancia
  - Kosice, Slovakia, 040 01
    - CARDIO D&R s.r.o. , Kardiologicka ambulancia
  - Kosice, Slovakia, 04011
    - AGTO., spol. s r. o.
  - Kosice, Slovakia, 04022
    - Cardio D&R spol.s.r.o., kardiologicka ambulancia
  - Kralovsky Chlmec, Slovakia, 077 01
    - Medicentrum Heart, Spol. S.R.O
  - Levice, Slovakia, 93405
    - CELL-B s.r.o. interna ambulancia
  - Liptovsky Mikulas, Slovakia, 031 23
    - Liptovska nemocnica s poliklinikou MUDr.Ivana Stodolu Liptovsky Mikulas
  - Lucenec, Slovakia, 984 39
    - Kardio 1 S.R.O.
  - Martin, Slovakia, 03659
    - Klinika hematologie a transfuziologie, Univerzitna nemocnica Martin
  - Moldava nad Bodvou, Slovakia, 045 01
    - MEDI M&M s.r.o., Ambulancia vnutorneho lekarstva
  - Namestovo, Slovakia, 02901
    - MUDr. Kanderkova s.r.o., Diabetologicka ambulancia
  - Nitra, Slovakia, 94901
    - Kardiocentrum Nitra s.r.o., kardiologicka ambulancia
  - Nove Zamky, Slovakia, 940 34
    - Fakultna nemocnica s poliklinikou Nove Zamky
  - Pezinok, Slovakia, 90201
    - Mediab s.r.o. Diabetologicka ambulancia
  - Piestany, Slovakia, 921 01
    - BENIMED s.r.o.
  - Presov, Slovakia, 08001
    - MEDISPOL s.r.o.
  - Rimavska Sobota, Slovakia, 979 01
    - Medilex s.r.o. Interna ambulancia
  - Rimavska Sobota, Slovakia, 97901
    - Kardioamb S.R.O.
  - Trencin, Slovakia, 911 01
    - DIAMEL, s.r.o., Diabetologicka ambulancia
  - Trnava, Slovakia, 917 01
    - BV Medical, s.r.o. Diabetologicka ambulancia,
  - Trnava, Slovakia, 917 01
    - Kardiologická ambulancia
  - Zilina, Slovakia, 010 01
    - MEDIVASA, s.r.o.
- Bratislavsky
  - Bratislava, Bratislavsky, Slovakia, 826 06
    - Nemocnica Ruzinov-Univerzitna Nemocnica Bratislava (UNB)
South Africa
- - Arcadia, Pretoria, South Africa, 0001
    - Global Clinical Trials (Pty) Ltd.
  - Centurion, South Africa, 0157
    - Unitas Hospital
  - Gauteng, South Africa, 1619
    - Clinresco Centres (Pty) Ltd-Central Professional Suits
  - Johannesburg, South Africa, 2198
    - Centre for Diabetes and Endocrinology
  - Paarl, South Africa, 7646
    - Paarl Research Centre
  - Parow, South Africa, 7500
    - TREAD Research CC
  - Worcester, South Africa, 6850
    - Clinical Projects Research SA (PTY) LTD
- Durban
  - Merebank, Durban, South Africa, 4052
    - Nash Ranjith Research Centre
- FREE State
  - Bloemfontein, FREE State, South Africa, 9301
    - Josha Research
  - Bloemfontein, FREE State, South Africa, 9301
    - Iatros International
  - Welkom, FREE State, South Africa, 9460
    - Welkom Clinical Trial Centre
- Gauteng
  - Halfway House, Gauteng, South Africa, 1685
    - Midrand Medical Centre
  - Johannesburg, Gauteng, South Africa, 1459
    - Sunward Park Hospital
  - Johannesburg, Gauteng, South Africa, 2157
    - Sunninghill Hospital
  - Lyttelton, Gauteng, South Africa, 0157
    - I Engelbrecht Research (Pty) Ltd
  - Parktown, Gauteng, South Africa, 2193
    - Charlotte Maxeke Johannesburg Academic Hospital
  - Pretoria, Gauteng, South Africa, 0184
    - Synexus Watermeyer Clinical Research Centre
  - Pretoria, Gauteng, South Africa, 0158
    - Medipark Centre for Clinical Research
  - Pretoria West, Gauteng, South Africa, 0183
    - Jongaie Research
  - Roodepoort, Gauteng, South Africa, 1724
    - Roodepoort Medicross Clinical Research Centre
  - Soweto, Gauteng, South Africa, 2013
    - Wits Clinical Research
  - Sunnyside, Gauteng, South Africa, 0083
    - Medi-Clinic Heart Hospital
- Johannesburg
  - Sunninghill, Johannesburg, South Africa, 2191
    - Sunninghill Hospital
- Kwazulu-natal
  - Durban, Kwazulu-natal, South Africa, 4001
    - Glastonbury Medical Research Centre
  - Durban, Kwazulu-natal, South Africa, 4001
    - Suite 502
  - Durban, Kwazulu-natal, South Africa, 4091
    - Dr Ganesh c/o Dr NB Maharaj
- Limpopo
  - Thabazimbi, Limpopo, South Africa, 0380
    - Limpopo Clinical Research Initiative
- Mpumalanga
  - Moloto, Mpumalanga, South Africa, 1022
    - Zinakekele Medical Centre
  - Witbank (eMalahleni), Mpumalanga, South Africa, 1035
    - Drs Joynt Venter & Associates
- Western CAPE
  - Cape Town, Western CAPE, South Africa, 7530
    - Tiervlei Trial Centre
  - Cape Town, Western CAPE, South Africa, 7130
    - Dr JM Engelbrecht Trial Site-Vergelegen Mediclinic
  - Cape Town, Western CAPE, South Africa, 7700
    - Synopsis Research cc
  - Somerset West, Western CAPE, South Africa, 7130
    - Helderberg Research Institute
  - Somerset West, Western CAPE, South Africa, 7130
    - Synexus Helderberg Clinical Research Centre
Spain
- - A Coruna, Spain, 15006
    - Complejo Hospitalario Universitario A Coruña
  - A Coruna, Spain, 15001
    - Hospital Abente y Lago
  - Albacete, Spain, 02006
    - Complejo Hospitalario Universitario de Albacete
  - Alicante, Spain, 03010
    - Hospital General Universitario de Alicante; Servicio Cardiologia
  - Almeria, Spain, 04120
    - Hospital Virgen del Mar
  - Barcelona, Spain, 08025
    - Hospital de la Santa Creu i Sant Pau
  - Barcelona, Spain, 08035
    - Hospital Universitari Vall d'Hebron
  - Barcelona, Spain, 08003
    - Parc de Salut mar ¿ Hospital del Mar
  - Barcelona, Spain, 08003
    - Parc de Salut Mar-Hospital del Mar
  - Barcelona, Spain, 08022
    - Centre Teknon
  - Barcelona, Spain, 08025
    - EAP Sardenya
  - Barcelona, Spain, 08540
    - CAP Centelles
  - Barcelona, Spain, 08923
    - Fundacio Hospital de I'Esperit Sant
  - Barcelona/Cataluna, Spain, 08820
    - CAP Disset De Setembre (Sant Cosme I Sant Damia)
  - Barcelona/Cataluña, Spain, 08400
    - Hospital General de Granollers
  - Ciudad Real, Spain, 13005
    - H. General Universitario de Ciudad Real
  - Cordoba, Spain, 14004
    - Hospital Universitario Reina Sofia
  - Ferrol, Spain, 15401
    - Complexo Hospitalario Universitario Arquitecto Marcide-Profesor Novoa Santos De Ferrol
  - Granada, Spain, 18014
    - Hospital Universitario Virgen de las Nieves (HUVN)
  - Granada, Spain, 18012
    - Hospital Universitario San Cecilio de Granada
  - Lleida, Spain, 25198
    - Hospital Universitari Arnau de Vilanova
  - Lugo, Spain, 27003
    - Hospital Universitario Lucus Augusti
  - Madrid, Spain, 28040
    - Fundacion Jimenez Diaz
  - Madrid, Spain, 28034
    - Hospital Universitario Ramon Y Cajal
  - Madrid, Spain, 28040
    - Hospital Universitario Fundacion Jimenez Diaz
  - Madrid, Spain, 28006
    - Hospital Universitario de La Princesa
  - Madrid, Spain, 28007
    - Hospital General Universitario Gregorio Maranon
  - Madrid, Spain, 28223
    - Hospital Universitario Quiron Madrid
  - Madrid, Spain, 28029
    - Hospital Carlos III
  - Madrid, Spain, 28046
    - Hospital Universitario La Paz; Unidad Metabolico-Vascular
  - Malaga, Spain, 29010
    - Hospital Universitario Virgen de la Victoria
  - Malaga, Spain, 29006
    - Hospital Universitario Virgen de la Victoria
  - Malaga, Spain, 29009
    - Hospital Regional Universitario de Malaga
  - Murcia, Spain, 30008
    - Hospital General Universitario Morales Meseguer
  - Sevilla, Spain, 41009
    - Hospital Universitario Virgen Macarena
  - Sevilla, Spain, 41013
    - Hospital Universitario Virgen Del Rocio
  - Sevilla, Spain, 41014
    - Hospital Universitario Virgen de Valme
  - Sevilla, Spain, 41003
    - Clínica Nuevas Tecnologías en Diabetes y Endocrinología
  - Tarragona, Spain, 43002
    - CAP Muralles
  - Valencia, Spain, 46014
    - Hospital General Universitario de Valencia
  - Vigo, Spain, 36312
    - Hospital Alvaro Cunqueiro (Hospital Meixoerio)
  - Zaragoza, Spain, 50009
    - Hospital Clinico Universitario Miguel Servet; Medicina Interna
- A Coruna
  - Santiago de Compostela, A Coruna, Spain, 15706
    - Hospital Clínico Universitario de Santiago de Compostela
  - Santiago de Compostela, A Coruna, Spain, 15706
    - Hospital Universitario de Santiago de Compostela
- Alicante
  - Alcoy, Alicante, Spain, 03804
    - Hospital Virgen de los Lirios
  - Elda, Alicante, Spain, 03600
    - Hospital General Comarcal de Elda Virgen de la Salud
- Andalucia
  - Malaga, Andalucia, Spain, 29010
    - Hospital Regional Universitario de Malaga
  - Sevilla, Andalucia, Spain, 41013
    - Hospital Universitario Virgen Del Rocio
- Asturias
  - Oviedo, Asturias, Spain, 33006
    - Centro de Salud El Cristo
  - Oviedo, Asturias, Spain, 33009
    - Centro Salud Paulino Prieto
- Barcelona
  - L'Hospitalet de Llobregat, Barcelona, Spain, 08907
    - Hospital Universitari de Bellvitge
  - L'Hospitalet de Llobregat, Barcelona, Spain, 08907
    - Hospital Universitario de Bellvitge
  - Sant Adria De Besos, Barcelona, Spain, 08930
    - CAP La Mina
  - Vic, Barcelona, Spain, 08500
    - EAP Vic
- Barcelona-cataluna
  - L'Hospitalet De Llobregat, Barcelona-cataluna, Spain, 08905
    - CAP Florida
- Barcelona/cataluña
  - Granollers, Barcelona/cataluña, Spain, 08400
    - Hospital General de Granollers
- Cantabria
  - Santander, Cantabria, Spain, 39008
    - Hospital Universitario Marqués de Valdecilla
- Catalonia
  - Lleida, Catalonia, Spain, 25198
    - Institut Catala De La Salut - Hospital Universitari Arnau De Vilanova (Huav)
  - Tarragona, Catalonia, Spain, 43007
    - Hospital Universitari de Tarragona Joan XXIII
- Comunidad Valenciana
  - San Juan De Alicante (Alicante), Comunidad Valenciana, Spain, 03550
    - Hospital Universitario San Juan de Alicante
- Gerona
  - Peralada, Gerona, Spain, 17491
    - Albera Salut
- Girona-catalonia
  - Figueres, Girona-catalonia, Spain, 17600
    - Hospital de Figueres
- Illes Balears
  - Inca, Illes Balears, Spain, 07300
    - Hospital Comarcal d'Inca
- Islas Baleares
  - Palma de Mallorca, Islas Baleares, Spain, 07198
    - Hospital Son Llatzer
  - Palma de Mallorca, Islas Baleares, Spain, 07014
    - Clínica Juaneda
- LA Coruna
  - El Ferrol, LA Coruna, Spain, 15405
    - Hospital Arquitecto Marcide
- Madrid
  - Alcala De Henares, Madrid, Spain, 28805
    - H. U. Principe de Asturias
  - Alcala De Henares, Madrid, Spain, 28805
    - Hospital Principe de Asturias
  - Alcala De Henares, Madrid, Spain, 28805
    - Hospital Universitario Príncipe de Asturias
  - Alcorcon, Madrid, Spain, 28922
    - Hospital Universitario Fundacion Alcorcon
  - Majadahonda, Madrid, Spain, 28222
    - Hospital Universitario Puerta de Hierro - Majadahonda
  - Majadahonda, Madrid, Spain, 28222
    - Hospital Universitario Puerta de Hierro
- Navarra
  - Pamplona, Navarra, Spain, 31008
    - Complejo Hospitalario de Navarra
- Oviedo Asturias
  - Colloto, Oviedo Asturias, Spain, 33010
    - Consultorio de Colloto
- PAIS Vasco
  - Barakaldo, PAIS Vasco, Spain, 48903
    - Hospital Universitario de Cruces
- Tarragona
  - Reus, Tarragona, Spain, 43204
    - Hospital Universitario Sant Joan de Reus
- Valencia
  - Requena, Valencia, Spain, 46340
    - Hospital General de Requena
Sweden
- - Eksjö, Sweden, 57535
    - Kasernens Läkarservice AB
  - Goteborg, Sweden, 413 45
    - Clinical Trial Center (CTC)/Centrum foer klinisk proevning
  - Goteborg, Sweden, 41345
    - Sahlgrenska Universitetssjukhuset
  - Gothenburg, Sweden, 41345
    - Centrum for klinisk provning-Sahlgrenska Universitetssjukhus
  - Helsingborg, Sweden, 25220
    - Pharmasite AB
  - Karlstad, Sweden, 65185
    - Centralsjukhuset Karlstad
  - Kristianstad, Sweden, 291 85
    - Centralsjukhuset Kristianstad
  - Lund, Sweden, 221 21
    - Capio Citykliniken Hjartmottagning
  - Lund, Sweden, 222 22
    - Probar E Lund AB
  - Malmo, Sweden, 205 02
    - Karlkliniken, Skanes Universitetssjukhus i Malmo
  - Malmo, Sweden, 211 52
    - Pharmasite
  - Molndal, Sweden, 431 80
    - Forskningsenheten, Medicinmottagningen Sahlgrenska Universitetssjukhuset/Molndal, Hus J
  - Ostersund, Sweden, 83183
    - Ostersunds sjukhus
  - Rattvik, Sweden, 79530
    - Dalecarlia Clinical Research Center
  - Skelleftea, Sweden, 93186
    - Skellefteå lasarett
  - Stockholm, Sweden, 118 83
    - Södersjukhuset AB
  - Stockholm, Sweden, 111 57
    - Citydiabetes
  - Stockholm, Sweden, 113 24
    - Karolinska Trial Alliance, KTA Prim
  - Stockholm, Sweden, 17176
    - Karolinska Universitetssjukhuset
  - Stockholm, Sweden, 188 82
    - Hjartkliniken
  - Uppsala, Sweden, 75185
    - Akademiska Sjukhuset
  - Vasteras, Sweden, 721 89
    - Västmanlands sjukhus Västerås
- Huddinge
  - Stockholm, Huddinge, Sweden, 141 86
    - Karolinska Universitetssjukhuset Huddinge
Switzerland
- - Geneve, Switzerland, 1211
    - Hôpitaux Universitaires de Genève
  - Lugano, Switzerland, CH-6900
    - Cardiocentro Ticino
  - Luzern 16, Switzerland, CH-6000
    - Luzerner Kantonsspital Luzern
  - St. Gallen, Switzerland, CH-9007
    - Kantonsspital St. Gallen
- Basel Stadt
  - Basel, Basel Stadt, Switzerland, 4031
    - Universitätsspital
- Basel Switzerland
  - Reinach, Basel Switzerland, Switzerland, 4153
    - Diagene Laboratories
- Ticino
  - Lugano, Ticino, Switzerland, 6900
    - Fondazione Diabete Lugano
- VD
  - Lausanne, VD, Switzerland, 1011
    - Centre Hospitalier Universitaire Vaudois (Chuv)
- Vaud
  - Lausanne, Vaud, Switzerland, 1011
    - Policlinique Medicale Universitaire
- Zurich
  - Winterthur, Zurich, Switzerland, 8401
    - Kantonsspital Winterthur
Taiwan
- - Kaohsiung, Taiwan, 807
    - Kaohsiung Medical University Chung-Ho Memorial Hospital - New
  - Tainan, Taiwan, 70403
    - National Cheng Kung University Hospital
  - Tainan, Taiwan, 70403
    - National Cheng Kung University (NCKU) Hospital
  - Taipei, Taiwan, 10002
    - National Taiwan University Hospital
  - Taipei, Taiwan, 11217
    - Taipei Veterans General Hospital
  - Taipei, Taiwan, 10449
    - Mackay Memorial Hospital
- Taiwan R O C
  - Taichung, Taiwan R O C, Taiwan, 40447
    - China Medical University Hospital
- Taiwan ROC
  - Taichung, Taiwan ROC, Taiwan, 40201
    - Chung Shan Medical University Hospital
Thailand
- - Bangkok, Thailand, 10400
    - Division Of cardiology,Department of Medicine,Faculty Of Medicine,Chulalongkorn University
- Bangkok
  - Bangkoknoi, Bangkok, Thailand, 10700
    - Division of Cardiology, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol
  - Rajathevee, Bangkok, Thailand, 10400
    - Clinical Research Center, Phramongkutklao Hospital
  - Rajathevee, Bangkok, Thailand, 10400
    - Endocrine Unit, Department of Medicine, Phramongkutklao Hospital
  - Ratchathewi, Bangkok, Thailand, 10400
    - Cardiology Unit, Department of Medicine, Faculty of Medicine,Ramathibodi Hospital,Mahidol University
- Khon Kaen
  - Muang, Khon Kaen, Thailand, 40002
    - Division of Cardiology, Department of medicine,Faculty of Medicine, Srinagarind Hospital, Khon Kaen
- Songkhla
  - Hat Yai, Songkhla, Thailand, 90110
    - Division of Cardiology, Department of Medicine, Faculty of Medicine, Songklanagarind Hospital,
- Songkla
  - Hat Yai, Songkla, Thailand, 90110
    - Heart Center, Songklanagarind Prince of Songkla University
Turkey
- - Adana, Turkey, 01250
    - Baskent University, Adana Yuregir Training & Research Hospital
  - Afyonkarahisar, Turkey, 03200
    - A.karahisar Kocatepe Universitesi Hastanesi Ahmet Necdet Sezer Uygulama ve Arastirma Hastanesi
  - Ankara, Turkey, 06110
    - Diskapi Yildirim Beyazit Egitim ve Arastirma Hastanesi
  - Antalya, Turkey, 07059
    - Akdeniz Universitesi Tip Fakultesi
  - Antalya, Turkey, 07058
    - Akdeniz Universitesi Tip Fakultesi Hastanesi
  - Antalya, Turkey, 07100
    - Antalya Training & Research Hospital
  - Bursa, Turkey, 16320
    - Bursa Yuksek Ihtisas Egitim ve Arastirma Hastanesi
  - Gaziantep, Turkey, 27310
    - Gaziantep Universitesi Tip Fakultesi Sahinbey Egitim ve Arastirma Hastanesi
  - Istanbul, Turkey, 34093
    - Istanbul Universitesi Istanbul Tip Fakultesi
  - Istanbul, Turkey, 34093
    - Bezmialem Vakif Universitesi Tip Fakultesi Kardiyoloji Anabilim Dali
  - Istanbul, Turkey, 34093
    - Bezmialem Vakif Universitesi Tip Fakultesi Kardiyoloji Bolumu
  - Istanbul, Turkey, 34096
    - Istanbul Universitesi Kardiyoloji Enstitusu
  - Istanbul, Turkey, 34752
    - Yeditepe University School of Medicine
  - Izmir, Turkey, 35340
    - Dokuz Eylul Universitesi Tip Fakultesi
  - Izmir, Turkey, 35100
    - Ege University, School of Medicine
  - Kocaeli, Turkey, 41380
    - Kocaeli University School Of Medicine-Kocaeli Universitesi Tip Fakultesi
  - Kutahya, Turkey, 43100
    - Dumlupinar Universitesi Kutahya Evliya Celebi EAH
  - Mersin, Turkey, 33343
    - Mersin University, School of Medicine
  - Rize, Turkey, 53020
    - Recep Tayyip Erdogan University School of Medicine, Training & Research Hospital
- Ankara
  - Izmir, Ankara, Turkey, 35340
    - Dokuz Eylul Univesitesi Tip Fakultesi Hastanesi
United Kingdom
- - Barnet, United Kingdom, EN5 3DJ
    - Royal Free London NHS Foundation Trust
  - Belfast, United Kingdom, BT12 6BA
    - Royal Victoria Hospital
  - Birmingham, United Kingdom, B6 6BB
    - Laurie Pike Health Centre
  - Birmingham, United Kingdom, B9 5SS
    - Heart of England NHS Foundation Trust, Dept. of Clinical Biochemistry & Immunology
  - Bolton, United Kingdom, BL4 0JR
    - Royal Bolton Hospital - Bolton Nhs Foundation Trust
  - Cardiff, United Kingdom, CF14 5GJ
    - Synexus Wales Clinical Research Centre
  - Chesterfield, United Kingdom, S404AA
    - Ashgate Medical Practice
  - East Sussex, United Kingdom, TN37 7RD
    - Conquest Hospital - East Sussex Healthcare NHS Trust
  - East Sussex, United Kingdom, TN39 4SP
    - Little Common Surgery
  - East Sussex, United Kingdom, TN40 1JJ
    - Sea Road Surgery
  - Ely, United Kingdom, CB7 5JD
    - Staploe Medical Centre
  - Glasgow, United Kingdom, G51 4TF
    - The Queen Elizabeth University Hospital- NHS Greater Glasgow and Clyde
  - Glasgow, United Kingdom, G69 7AD
    - McGlone Practice Baillieston Health Centre
  - Hinckley, United Kingdom, LE10 2SE
    - Burbage Surgery
  - London, United Kingdom, NW3 2QG
    - Royal Free Hospital
  - London, United Kingdom, EC1M 6BQ
    - William Harvey Heart Centre (WHHC)
  - London, United Kingdom, W12 OHS
    - Peart-Rose Research Unit, Hammersmith Hospital, Imperial College NHS Trust
  - Middlesbrough, United Kingdom, TS4 3BW
    - The Red Porto cabin, The James Cook University Hospital
  - Newport, United Kingdom, PO30 5TG
    - St Mary's Hospital
  - Peterborough, United Kingdom, PE8 6PL
    - Wansford and Kings Cliffe Practice
  - Rothwell, Northants, United Kingdom, NN14 6JQ
    - Rothwell and Desborough Healthcare Group
  - Swansea, United Kingdom, SA2 8PP
    - Abertawe Bro Morgannwg University Local Health Board
  - Worthing, United Kingdom, BN11 2DH
    - Western Sussex Hospitals NHS Trust
  - York, United Kingdom, YO30 6AE
    - York Medical Group
  - York, United Kingdom, YO32 5UA
    - Strensall Healthcare Centre
- Berkshire
  - Reading, Berkshire, United Kingdom, RG2 0TG
    - Synexus Thames Valley Clinical Research Centre
- Buckinghamshire
  - Aylesbury, Buckinghamshire, United Kingdom, HP22 5LB
    - Westongrove Research Centre
- Cambridgeshire
  - Peterborough, Cambridgeshire, United Kingdom, PE3 9GZ
    - Peterborough City Hospital
- Cornwall
  - Penzance, Cornwall, United Kingdom, TR18 4EL
    - Morrab Surgery
  - St Austell, Cornwall, United Kingdom, PL26 7RL
    - Brannel Surgery
- EAST Yorkshire
  - Hull, EAST Yorkshire, United Kingdom, HU3 2RW
    - The Michael White Centre for Diabetes & Endocrinology, Hull Royal Infirmary
- Essex
  - Romford, Essex, United Kingdom, RM7 0AG
    - Queen's Hospital
- Greater Manchester
  - Manchester, Greater Manchester, United Kingdom, M15 6SX
    - Synexus Manchester Clinical Research Centre-Manchester Science Park
  - Oldham, Greater Manchester, United Kingdom, OL1 2JH
    - Royal Oldham Hospital
- Hampshire
  - Chandlers Ford, Hampshire, United Kingdom, SO53 2ZH
    - St Francis Surgery
- Hertfordshire
  - Stevenage, Hertfordshire, United Kingdom, SG1 4AB
    - Lister Hospital
  - Welwyn Garden City, Hertfordshire, United Kingdom, AL7 4HQ
    - East and North Hertfordshire NHS Trust
  - Welwyn Garden City, Hertfordshire, United Kingdom, AL7 4HQ
    - Howlands Clinic - Queen Elizabeth II Hospital
- Lanarkshire
  - Glasgow, Lanarkshire, United Kingdom, G20 0SP
    - Synexus Scotland Clinical Research Centre
- Lancashire
  - Blackpool, Lancashire, United Kingdom, FY3 7EN
    - Layton Medical Centre
  - Chorley, Lancashire, United Kingdom, PR7 7NA
    - Synexus Lancashire Clinical Research Centre
- M6 8hd
  - Salford, M6 8hd, United Kingdom, M6 8HD
    - Salford Royal NHS Foundation Trust - Dermatology Centre
- Merseyside
  - Liverpool, Merseyside, United Kingdom, L22 0LG
    - Synexus Merseyside Clinical Research Centre
  - Liverpool, Merseyside, United Kingdom, L78XP
    - The Royal Liverpool and Broadgreen -University Hospitals NHS Trust
- North Yorkshire
  - Whitby, North Yorkshire, United Kingdom, YO21 1SD
    - Whitby Group Practice
- Northants
  - Wellingborough, Northants, United Kingdom, NN84RW
    - Albany House Medical Centre
- Northern Ireland
  - Portadown, Northern Ireland, United Kingdom, BT63 5QQ
    - Southern Health & Social Care Trust, Craigavon Area Hospital
- Northumberland
  - Hexham, Northumberland, United Kingdom, NE46 1QJ
    - Synexus North East Clinical Research Centre - Hexham General Hospital
- South Yorkshire
  - Doncaster, South Yorkshire, United Kingdom, DN9 2HY
    - South Axholme Practice
  - Manchester, South Yorkshire, United Kingdom, M13 9WL
    - Central Manchester University Hospitals NHS Foundation Trust
- Surrey
  - Addlestone, Surrey, United Kingdom, KT15 2BH
    - The Crouch Oak Family Practice
- WEST Midlands
  - Birmingham, WEST Midlands, United Kingdom, B15 2SQ
    - Synexus Midlands Clinical Research Centre
  - Birmingham, WEST Midlands, United Kingdom, B18 7QH
    - City Hospital
- WEST Wales
  - Llanelli, WEST Wales, United Kingdom, SA14 8QF
    - Prince Philip Hospital
- Wales
  - Cardiff, Wales, United Kingdom, CF5 4AD
    - Ely Bridge Surgery
- West Mids
  - Birmingham, West Mids, United Kingdom, B9 5SS
    - Heart of England NHS Trust
United States
- Alabama
  - Athens, Alabama, United States, 35611
    - North Alabama Research Center LLC
  - Athens, Alabama, United States, 35611
    - Ernest Hendrix, MD, PC
  - Birmingham, Alabama, United States, 35294
    - University of Alabama at Birmingham
  - Birmingham, Alabama, United States, 35211
    - Clinical Research Advantage, Inc./Simon Williamson Clinic
  - Birmingham, Alabama, United States, 35209
    - Central Alabama Research
  - Birmingham, Alabama, United States, 35235
    - Birmingham Heart Clinic, P.C.
  - Birmingham, Alabama, United States, 35243
    - Cardiovascular Associates of the Southeast, LLC
  - Fort Payne, Alabama, United States, 35967
    - Appalachian Cardiovascular Associates
  - Gulf Shores, Alabama, United States, 36542
    - Fundamental Research, LLC
  - Guntersville, Alabama, United States, 35976
    - Avant Research Associates, LLC
  - Hamilton, Alabama, United States, 35570
    - Boyett Health Services
  - Huntsville, Alabama, United States, 35801
    - Saadat Ansari Internal Medicine
  - Mobile, Alabama, United States, 36608
    - CB Flock Research Corporation
- Alaska
  - Anchorage, Alaska, United States, 99508
    - Alaska Heart Institute
- Arizona
  - Glendale, Arizona, United States, 85306
    - Phoenix Heart, PLLC
  - Glendale, Arizona, United States, 85308
    - Arrowhead Internal Medicine
  - Phoenix, Arizona, United States, 85029
    - Redpoint Research
  - Phoenix, Arizona, United States, 85018
    - Clinical Research Advantage, Inc./Family Practice Specialists, Ltd.
  - Sierra Vista, Arizona, United States, 85635
    - Cochise Clinical Research
  - Tempe, Arizona, United States, 85282
    - Clinical Research Advantage, Inc. (Administrative Mailing Only)
  - Tucson, Arizona, United States, 85710
    - Southwest Heart Group
  - Tucson, Arizona, United States, 85713
    - University of Arizona Medical Center South Campus
  - Tucson, Arizona, United States, 85715
    - Arizona Endocrine and Rheumatology Associates
- Arkansas
  - Little Rock, Arkansas, United States, 72211
    - Arkansas Heart Hospital Clinic
  - Little Rock, Arkansas, United States, 72211
    - Arkansas Site Management Services, LLC
- California
  - Anaheim, California, United States, 92801
    - Cardiology Consultants of Orange County Medical Group Inc.
  - Bakersfield, California, United States, 93309
    - Premier Valley Medical Group
  - Beverly Hills, California, United States, 90211
    - Westside Medical Associates of Los Angeles
  - Beverly Hills, California, United States, 90210
    - Cardiovascular Research Foundation of Southern California
  - Buena Park, California, United States, 90620
    - Southbay Pharma Research
  - Carmichael, California, United States, 95608
    - Med Center
  - Cerritos, California, United States, 90703
    - Pioneer Medical Group
  - Concord, California, United States, 94520
    - John Muir Physician Network Clinical Research Center
  - Cudahy, California, United States, 90201
    - Atlantic Ave Medical Clinic Inc.
  - Downey, California, United States, 90241
    - Multani Medical Group
  - El Cajon, California, United States, 92020
    - TriWest Research Associates, LLC
  - Encinitas, California, United States, 92024
    - Diagnamics, Inc.
  - Encino, California, United States, 91436
    - T. Joseph Raoof, Md, Inc/Encino Research Center
  - Escondido, California, United States, 92025
    - AVIVA Research
  - Fair Oaks, California, United States, 95628
    - Med Investigations, Inc.
  - Fresno, California, United States, 93720
    - Valley Research
  - Fullerton, California, United States, 92835
    - St. Jude Hospital Yorba Linda dba St. Joseph Heritage Healthcare
  - La Palma, California, United States, 90623
    - Omnibus Clinical Research
  - Laguna Hills, California, United States, 92653
    - Alliance Research Centers
  - Laguna Hills, California, United States, 92653
    - Prime Care Clinical Research Center
  - Lincoln, California, United States, 95648
    - Clinical Trials Research
  - Long Beach, California, United States, 90806
    - Long Beach Memorial Medical Center
  - Los Angeles, California, United States, 90022
    - Academic Medical Research Institute
  - Los Angeles, California, United States, 90017
    - American Institute of Research
  - Los Angeles, California, United States, 90017
    - Intermed Group
  - Los Angeles, California, United States, 90022
    - Eastside Clinical Research Associates
  - Los Gatos, California, United States, 95032
    - Richard S. Cherlin, MD
  - Mission Hills, California, United States, 91345
    - Facey Medical Foundation
  - Northridge, California, United States, 91325
    - Valley Clinical Trials, Inc.
  - Northridge, California, United States, 91324
    - California Medical Research Associates Inc.
  - Orange, California, United States, 92868
    - Diabetes Associates Medical Group
  - Port Hueneme, California, United States, 93041
    - Saviers Medical Group
  - Poway, California, United States, 92064
    - Arch Health Partners
  - Redondo Beach, California, United States, 90277
    - A. R. I. Clinical Trials, Inc.
  - San Diego, California, United States, 92103-6204
    - California Research Foundation
  - San Diego, California, United States, 92111
    - San Diego Family Care dba Linda Vista Health Center
  - San Diego, California, United States, 92111
    - San Diego Family Care
  - San Diego, California, United States, 92117
    - Ritchken & First Md's
  - San Diego, California, United States, 92120
    - Wetlin Research Associates, Inc.
  - San Ramon, California, United States, 94582
    - West Coast Research LLC
  - Santa Ana, California, United States, 92705
    - Syrentis Clinical Research
  - Santa Monica, California, United States, 90404
    - Coastal Biomedical Research, Inc.
  - Spring Valley, California, United States, 91978
    - Encompass Clinical Research
  - Stockton, California, United States, 95204
    - St. Joseph's Medical Associates
  - Thousand Oaks, California, United States, 91360
    - Westlake Medical Research
  - Torrance, California, United States, 90502
    - Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
  - Torrance, California, United States, 90509
    - Harbor - UCLA Medical Center
  - Torrance, California, United States, 90502
    - Los Angeles Biomedical Research Institute at Harbor - UCLA Medical Center
  - Tustin, California, United States, 92780
    - Orange County Research Center
  - Valley Village, California, United States, 91607
    - Bayview Research Group
  - Ventura, California, United States, 93003
    - Ventura Clinical Trials
  - Ventura, California, United States, 93003
    - Coastal Metabolic Research Centre
  - Vista, California, United States, 92083
    - Clinical Research Advantage, Inc. / Cassidy Medical Group - Vista
  - Westminster, California, United States, 92683
    - Allianz Research Institute
  - Whittier, California, United States, 90603
    - American Institute of Research Studies
  - Wildomar, California, United States, 92595
    - Elite Clinical Trials, Inc.
  - Wildomar, California, United States, 92595
    - Elite Clinical Trials, Incorporated
- Colorado
  - Colorado Springs, Colorado, United States, 80909
    - Lynn Institute Of The Rockies
  - Colorado Springs, Colorado, United States, 80906
    - Colorado Springs Health Partners
  - Colorado Springs, Colorado, United States, 80909
    - Expresscare Clinical Research
  - Colorado Springs, Colorado, United States, 80909
    - Memorial Hospital: University of Colorado Health
  - Denver, Colorado, United States, 80246
    - Lynn Institute of Denver
  - Glenwood Springs, Colorado, United States, 81601
    - Western Colorado Research, LLC
  - Littleton, Colorado, United States, 80120
    - South Denver Cardiology Associates, PC
- Connecticut
  - Bridgeport, Connecticut, United States, 06610
    - Bridgeport Hospital
  - Bridgeport, Connecticut, United States, 06606
    - Connecticut Clinical Research, Llc
  - Hartford, Connecticut, United States, 06102
    - Hartford Hospital
  - Stamford, Connecticut, United States, 06905
    - Stamford Therapeutics Consortium
  - Stamford, Connecticut, United States, 06905
    - Cardiology Associates of Fairfield County, PC
- Delaware
  - Newark, Delaware, United States, 19713
    - Christiana Care Health Services, Inc.
  - Wilmington, Delaware, United States, 19803
    - Alfieri Cardiology
- District of Columbia
  - Washington, District of Columbia, United States, 20036
    - Capital Medical Associates, PC
- Florida
  - Atlantis, Florida, United States, 33462
    - ACRC - Cardiology
  - Brooksville, Florida, United States, 34601
    - Meridien Research
  - Clearwater, Florida, United States, 33756
    - Gulf Coast Endocrine and Diabetes Center
  - Coral Gables, Florida, United States, 33134
    - Team Medical Research
  - Daytona Beach, Florida, United States, 32117
    - Cardiology Associates Research Company
  - Daytona Beach, Florida, United States, 32114
    - The Heart Group, PA
  - Delray Beach, Florida, United States, 33484
    - Seidman Clinical Trials
  - Delray Beach, Florida, United States, 33484
    - The Cardiology Center
  - Doral, Florida, United States, 33166
    - Integrity Clinical Research, LLC
  - Doral, Florida, United States, 33166
    - Moonshine Research Center, Inc.
  - Doral, Florida, United States, 33166
    - Care Research Center Inc
  - Doral, Florida, United States, 33126
    - Continental Research Corp
  - Doral, Florida, United States, 33172
    - Advanced Clinical Research of Miami (ACROM) International
  - Fort Lauderdale, Florida, United States, 33312
    - The Center for Diabetes and Endocrine Care
  - Fort Lauderdale, Florida, United States, 33308
    - InvesClinic, LLC
  - Fort Lauderdale, Florida, United States, 33308
    - The Office of Alan Graff, MD, PA
  - Fort Lauderdale, Florida, United States, 33316
    - Broward Health Medical Center (BHMC) (Broward General Medical Center (BGMC))
  - Fort Lauderdale, Florida, United States, 33316
    - The Office of Maxine E. Hamilton, MD, PA
  - Hialeah, Florida, United States, 33010
    - State Of The Art Research, LLC
  - Hialeah, Florida, United States, 33012
    - Direct Helpers Medical Center Inc
  - Hollywood, Florida, United States, 33021
    - Research Physicians Network Alliance
  - Hollywood, Florida, United States, 33024
    - Pines Clinical Research, Inc.
  - Jacksonville, Florida, United States, 32205
    - Westside Center for Clinical Research
  - Jacksonville, Florida, United States, 32216
    - Jacksonville Center for Clinical Research
  - Jacksonville, Florida, United States, 32216
    - East Coast Institute for Research, LLC
  - Jacksonville, Florida, United States, 32256
    - Solutions Through Advanced Research, Inc.
  - Jacksonville, Florida, United States, 32204
    - East Coast Institute for Research, LLC
  - Jacksonville, Florida, United States, 32207
    - River City Clinical Research
  - Jacksonville, Florida, United States, 32223
    - Baker-Gilmore Cardiovascular Institute
  - Lakeland, Florida, United States, 33805
    - Meridien Research
  - Largo, Florida, United States, 33770
    - The Heart Institute at Largo
  - Margate, Florida, United States, 33063
    - South Florida Clinical Research Institute
  - Melbourne, Florida, United States, 32934
    - Accelovance
  - Miami, Florida, United States, 33144
    - Medical Research Center
  - Miami, Florida, United States, 33183
    - International Research Associates, LLC
  - Miami, Florida, United States, 33147
    - Advanced Pharma Cr, Llc
  - Miami, Florida, United States, 33126
    - Finlay Medical Research
  - Miami, Florida, United States, 33126
    - Pharmax Research Clinic, Inc.
  - Miami, Florida, United States, 33135
    - South Florida Research Center, Inc.
  - Miami, Florida, United States, 33185
    - Kendall South Medical Center, Inc.
  - Miami, Florida, United States, 33144
    - Nuren Medical & Research Center
  - Miami, Florida, United States, 33186
    - Med Research Of Florida, LLC
  - Miami, Florida, United States, 33173
    - Research Institute of South Florida, Inc.
  - Miami, Florida, United States, 33122
    - Future Clinical Research, Inc.
  - Miami, Florida, United States, 33125
    - Advanced Clinical Research of Miami (ACROM) International
  - Miami, Florida, United States, 33125
    - Project4Research, Inc
  - Miami, Florida, United States, 33126
    - A & L Clinical research
  - Miami, Florida, United States, 33142
    - Florida Medical Center & Research, Inc.
  - Miami, Florida, United States, 33145
    - Doctors Research Institute
  - Miami, Florida, United States, 33155
    - Coast Research Institute
  - Miami, Florida, United States, 33155
    - My Community Research Center, Inc.
  - Miami, Florida, United States, 33165
    - Columbus Clinical Services LLC
  - Miami, Florida, United States, 33173
    - Cardiovascular Research Center of South Florida
  - Miami, Florida, United States, 33174
    - A & O Research Center, Inc.
  - Miami, Florida, United States, 33175
    - BWell Research Center
  - Miami, Florida, United States, 33175
    - Pharmacology International Research, Inc.
  - Miami, Florida, United States, 33176
    - Advanced Clinical Research
  - Miami, Florida, United States, 33176
    - South Florida Research Group, LLC
  - Miami, Florida, United States, 33185
    - M & M Medical Center, Inc
  - Miami Beach, Florida, United States, 33140
    - Research Physicians Network Alliance
  - Miami Lakes, Florida, United States, 33014
    - G & I Medical Research LLC
  - Naples, Florida, United States, 34102
    - Southwest Florida Research
  - New Port Richey, Florida, United States, 34653
    - BayCare Medical Group
  - New Port Richey, Florida, United States, 34653
    - The Heart & Vascular Institute Of Florida
  - North Bay Village, Florida, United States, 33141
    - Bravo Health Care Center
  - North Miami Beach, Florida, United States, 33162
    - Harmony Clincal Research, Inc.
  - Orlando, Florida, United States, 32803
    - Florida Hospital Cardiovascular Institute
  - Orlando, Florida, United States, 32806
    - Omega Research Consultants, LLC
  - Ormond Beach, Florida, United States, 32174
    - Millennium Research
  - Ormond Beach, Florida, United States, 32174
    - Aba Family Medicine, LLC
  - Ormond Beach, Florida, United States, 32174
    - Ribo Research, LLC dba Peninsula Research
  - Pembroke Pines, Florida, United States, 33029
    - DBC Research USA
  - Pembroke Pines, Florida, United States, 33027
    - South Broward Research
  - Pembroke Pines, Florida, United States, 33024
    - A&R Research Group, LLC
  - Pembroke Pines, Florida, United States, 33025
    - Research Physicians Network Alliance
  - Pembroke Pines, Florida, United States, 33029
    - DBC Research
  - Pensacola, Florida, United States, 32501
    - Cardiology Consultants
  - Pinellas Park, Florida, United States, 33782
    - DMI Research, Inc.
  - Plant City, Florida, United States, 33563
    - Clinical Research of Central Florida
  - Plant City, Florida, United States, 33563
    - Clincal Research of Florida
  - Plantation, Florida, United States, 33313-6066
    - Dr. Jeffrey Greiff MD, Office Of
  - Plantation, Florida, United States, 33313
    - Nova Clinical Research Collaborative
  - Ponte Vedra, Florida, United States, 32081
    - St. Johns Center for Clinical Research
  - Port Charlotte, Florida, United States, 33952
    - Charlotte Heart Group Research Center
  - Saint Petersburg, Florida, United States, 33709
    - Meridien Research
  - Saint Petersburg, Florida, United States, 33713
    - Advance Medical Research
  - Sarasota, Florida, United States, 34239
    - Cardiovascular Center of Sarasota
  - Sarasota, Florida, United States, 34232
    - Intercoastal Medical Group
  - Sarasota, Florida, United States, 34239
    - Heart & Vascular Center Research
  - Sarasota, Florida, United States, 34239
    - Intercoastal Medical Group (Drug Shipment Address and Administrative)
  - Seminole, Florida, United States, 33777
    - The Office of Bridget Bellingar, DO
  - Tamarac, Florida, United States, 33319
    - Vita Health & Medical Center, Inc./Concept Clinical Trials, LLC
  - Trinity, Florida, United States, 34655
    - Interventional Cardiac Consultants
  - Wellington, Florida, United States, 33449
    - Cardiology Partners Clinical Research Institute
  - West Palm Beach, Florida, United States, 33401
    - Metabolic Research Institute, Inc.
  - West Palm Beach, Florida, United States, 33401
    - Cleveland Clinic Cardiology Associates
  - Winter Haven, Florida, United States, 33880
    - Clinical Research of Central Florida
- Georgia
  - Atlanta, Georgia, United States, 30322
    - Emory University Hospital
  - Atlanta, Georgia, United States, 30318
    - Atlanta Diabetes Associates
  - Atlanta, Georgia, United States, 30331
    - Atlanta Center for Medical Research
  - Columbus, Georgia, United States, 31904
    - Columbus Regional Research Institute
  - Conyers, Georgia, United States, 30094
    - Rockdale Medical Research Associates
  - Covington, Georgia, United States, 30014
    - Georgia Heart Specialists, LLC
  - Decatur, Georgia, United States, 30033
    - NeuroStudies.net, LLC
  - Dunwoody, Georgia, United States, 30338
    - Alta Pharmaceutical Research Center
  - Norcross, Georgia, United States, 30071
    - In-Quest Medical Research, LLC
  - Roswell, Georgia, United States, 30075
    - Atlanta Center for Clinical Research / Internal Medicine
  - Snellville, Georgia, United States, 30078
    - Georgia Clinical Research, LLC
  - Snellville, Georgia, United States, 30039
    - Dr. B. Abraham, P.C.
  - Stockbridge, Georgia, United States, 30281
    - Clinical Research Atlanta
- Hawaii
  - Honolulu, Hawaii, United States, 96814
    - East-West Medical Research Institute
- Idaho
  - Blackfoot, Idaho, United States, 83221
    - Elite Clinial Trials, LLLP
  - Blackfoot, Idaho, United States, 83221
    - Elite Clinial Trials
  - Caldwell, Idaho, United States, 83605
    - St. Luke's Idaho Cardiology Associates
  - Meridian, Idaho, United States, 83646
    - Solaris Clinical Research
  - Nampa, Idaho, United States, 83686-6011
    - Saltzer Medical Group, PA
- Illinois
  - Arlington Heights, Illinois, United States, 60005
    - Northwest Heart Clinical Research, LLC
  - Chicago, Illinois, United States, 60604
    - Clinical Research Advantage, Inc./Michigan Avenue Internists
  - Chicago, Illinois, United States, 60616
    - Apex Medical Research, AMR, Inc.
  - Chicago, Illinois, United States, 60631
    - Clinical Research Advantage, Inc./Medical and Procedural Specialists of Illinois
  - Evanston, Illinois, United States, 60201
    - Evanston Premier Healthcare Research, LLC
  - Gurnee, Illinois, United States, 60031
    - Clinical Investigation Specialists, Inc
  - Mokena, Illinois, United States, 60448
    - Heart Care Centers of Illinois
  - Rock Island, Illinois, United States, 61201
    - Advanced Cardiovascular Consultants
- Indiana
  - Brownsburg, Indiana, United States, 46112
    - Investigators Research Group, LLC
  - Elwood, Indiana, United States, 46036
    - Investigative Clinical Research Of Indiana, Llc
  - Evansville, Indiana, United States, 47714
    - MediSphere Medical Research Center, LLC
  - Evansville, Indiana, United States, 47725
    - Deaconess Clinic Mt. Pleasant
  - Evansville, Indiana, United States, 47713
    - Deaconess Clinic Downtown
  - Evansville, Indiana, United States, 47714
    - Clinical Research Advantage, Inc. (IP Shipment and Research Site)
  - Evansville, Indiana, United States, 47725
    - Clinical Research Advantage, Inc. / Family Medicine Associates
  - Franklin, Indiana, United States, 46131
    - American Health Network of Indiana LLC
  - Greenfield, Indiana, United States, 46140
    - American Health Network of Indiana, LLC
  - Muncie, Indiana, United States, 47304
    - American Health Network of Indiana, LLC
  - Munster, Indiana, United States, 46321
    - Cardiovascular Research of Northwest Indiana, LLC
  - Valparaiso, Indiana, United States, 46383
    - Buynak Clinical Research, P.C.
- Iowa
  - Council Bluffs, Iowa, United States, 51501
    - West Broadway Clinic
  - Council Bluffs, Iowa, United States, 51503
    - Clinical Research Advantage, Inc.
  - Davenport, Iowa, United States, 52803
    - Midwest Cardiovascular Research Foundation
  - Iowa City, Iowa, United States, 52242
    - University of Iowa College of Public Health - Preventive Intervention Center
  - Waterloo, Iowa, United States, 50702
    - Northeast Iowa Medical Education Foundation
  - West Des Moines, Iowa, United States, 50266
    - The Iowa Clinic, PC
- Kansas
  - Hutchinson, Kansas, United States, 67502
    - Hutchinson Clinic, P.A
  - Kansas City, Kansas, United States, 66160
    - University of Kansas Medical Center
  - Newton, Kansas, United States, 67114
    - Heartland Research Associates, LLC
  - Overland Park, Kansas, United States, 66209
    - Midwest Heart & Vascular Specialists, LLC
  - Shawnee Mission, Kansas, United States, 66218
    - Women's & Family Care, LLC D.B.A GTC Research
- Kentucky
  - Elizabethtown, Kentucky, United States, 42701
    - Central Cardiology Associates Research
  - Lexington, Kentucky, United States, 40503
    - The Research Group of Lexington, LLC
  - Louisville, Kentucky, United States, 40213
    - L-MARC Research Center
  - Owensboro, Kentucky, United States, 42303
    - Research Integrity, LLC.
- Louisiana
  - Alexandria, Louisiana, United States, 71301
    - Alexandria Cardiology Clinic
  - Crowley, Louisiana, United States, 70526
    - Avant Research Associates, LLC
  - Lake Charles, Louisiana, United States, 70601
    - Centex Studies
  - Lake Charles, Louisiana, United States, 70601
    - Imperial Health, LLC
  - Marrero, Louisiana, United States, 70072
    - American Clinical Research, LLC
  - Marrero, Louisiana, United States, 70072
    - West Jefferson Heart Clinic of Louisiana New Orleans Physician Services, Inc.
  - Monroe, Louisiana, United States, 71201
    - Clinical Trials of America LA
  - Natchitoches, Louisiana, United States, 71457
    - KAMP Medical Research Inc.
  - Shreveport, Louisiana, United States, 71105
    - Grace Research, LLC
- Maine
  - Auburn, Maine, United States, 04210
    - Maine Research Associates
  - Bangor, Maine, United States, 04401
    - Acadia Clinical Research, LLC
  - Westbrook, Maine, United States, 04092
    - Cranbrook Cardiology Research Associates
- Maryland
  - Annapolis, Maryland, United States, 21401
    - Anne Arundel Medical Center
  - Annapolis, Maryland, United States, 21401
    - Medstar Cardiology Associates
  - Baltimore, Maryland, United States, 21229
    - Maryland Cardiovascular Specialists
  - Baltimore, Maryland, United States, 21236
    - Overlea Personal Physicians
  - Baltimore, Maryland, United States, 21204
    - MedStar Chesapeake CardioVascular Associates
  - Baltimore, Maryland, United States, 21218
    - Medstar Union Memorial Heart Specialists
  - Baltimore, Maryland, United States, 21237
    - Shahid Saeed, MD, PC
  - Glen Burnie, Maryland, United States, 21061
    - Maryland Heart Associates, LLC
  - Lutherville, Maryland, United States, 21093
    - Lutherville Personal Physicians
  - Oxon Hill, Maryland, United States, 20745
    - MD Medical Research
- Massachusetts
  - Framingham, Massachusetts, United States, 01702
    - Metro West Medical Center Research Clinic
  - Framingham, Massachusetts, United States, 01702
    - Metro West Medical Center
  - Framingham, Massachusetts, United States, 01702
    - MetroWest Medical Center - Pharmacy Department
  - Haverhill, Massachusetts, United States, 01830
    - Pentucket Medical Associates, LLC
  - Methuen, Massachusetts, United States, 01844
    - ActivMed Practices and Research, Inc.
  - Natick, Massachusetts, United States, 01760
    - Charles River Medical Associates
- Michigan
  - Alpena, Michigan, United States, 49707
    - Endeavor Medical Research
  - Ann Arbor, Michigan, United States, 48106
    - St. Joseph Mercy Health System
  - Ann Arbor, Michigan, United States, 48106
    - University of Michigan - Domino Farms
  - Chelsea, Michigan, United States, 48118
    - IHA Chelsea Family & Internal Medicine
  - Grandville, Michigan, United States, 49418
    - Healthy Heart Cardiology
  - Kalamazoo, Michigan, United States, 49009
    - Westside Family Medical Center, Pc
  - Lansing, Michigan, United States, 48912
    - Sparrow Clinical Research Institute
  - Lansing, Michigan, United States, 48912
    - Sparrow Thoracic & Cardiovascular Institute
  - Livonia, Michigan, United States, 48154
    - Detroit Clinical Research Center, PC
  - Midland, Michigan, United States, 48670
    - MidMichigan Medical Center Midland
  - Saginaw, Michigan, United States, 48601
    - Michigan Cardio Vascular Institute
  - Sterling Heights, Michigan, United States, 48310
    - Tri-County Research, Inc.
  - Traverse City, Michigan, United States, 49684
    - Medical Research Associates, Inc.
  - Troy, Michigan, United States, 48085
    - Oakland Medical Research Center
  - Troy, Michigan, United States, 48098
    - Arcturus Healthcare, plc, Troy Internal Medicine Research Division
  - Ypsilanti, Michigan, United States, 48197
    - Michigan Heart & Vascular Institute
- Minnesota
  - Duluth, Minnesota, United States, 55805
    - Duluth Clinic, dba Essentia Health Duluth Clinic Investigational Drug Room
  - Duluth, Minnesota, United States, 55805
    - St. Mary's Medical Center (Primary Practice Site)
  - Edina, Minnesota, United States, 55435
    - Radiant Research, Inc.
  - Golden Valley, Minnesota, United States, 55422
    - Minneapolis Clinic of Neurology
  - Minneapolis, Minnesota, United States, 55407
    - Allina Health System, dba Abbott Northwestern Hospital
  - Minneapolis, Minnesota, United States, 55455
    - Lillehei Clinical Research Unit, University of Minnesota
  - Saint Cloud, Minnesota, United States, 56303
    - CentraCare Heart and Vascular Center
  - Saint Paul, Minnesota, United States, 55102
    - HealthEast Medical Research Institute
  - Saint Paul, Minnesota, United States, 55102
    - HealthEast St. Joseph's Hospital Pharmacy
- Mississippi
  - Jackson, Mississippi, United States, 39209
    - Phillips Medical Services, PLLC
  - Olive Branch, Mississippi, United States, 38654
    - Olive Branch Family Medical Center
  - Tupelo, Mississippi, United States, 38801
    - Cardiology Associates Research, LLC
- Missouri
  - Columbia, Missouri, United States, 65201
    - Missouri Cardiovascular Specialists, LLP
  - Kansas City, Missouri, United States, 64111
    - Saint Luke's Lipid and Diabetes Research Center
  - Kansas City, Missouri, United States, 64128-2226
    - Kansas City VA Medical Center
  - Saint Louis, Missouri, United States, 63141
    - Mercy Research
- Montana
  - Kalispell, Montana, United States, 55901
    - Glacier View Research Institute
  - Kalispell, Montana, United States, 59901
    - Glacier View Research Institute, Cardiology
  - Missoula, Montana, United States, 59808
    - Montana Medical Research Inc.
- Nebraska
  - Elkhorn, Nebraska, United States, 68022
    - Clinical Research Advantage, Inc./Skyline Medical Center, PC
  - Lincoln, Nebraska, United States, 68506
    - Bryan Heart
  - Omaha, Nebraska, United States, 68131
    - Creighton Diabetes Center
  - Omaha, Nebraska, United States, 68198-4120
    - University of Nebraska Medical Center
  - Omaha, Nebraska, United States, 68198-4130
    - University of Nebraska Medical Center
- Nevada
  - Las Vegas, Nevada, United States, 89119
    - AB Clinical Trials
  - Las Vegas, Nevada, United States, 89121
    - Clinical Research of South Nevada
  - Las Vegas, Nevada, United States, 89128
    - Clinical Research Advantage, Inc.
- New Jersey
  - Belvidere, New Jersey, United States, 07823
    - John V. Bernard, MD dba Wellness and Research Center
  - Bridgewater, New Jersey, United States, 08807
    - Advanced Heart Care LLC
  - Cherry Hill, New Jersey, United States, 08034
    - Lourdes Cardiology Services
  - Elizabeth, New Jersey, United States, 07201
    - USMA Clinical Research
  - Hammonton, New Jersey, United States, 08037
    - Lourdes Cardiology Services
  - Linden, New Jersey, United States, 07036
    - NJ Heart
  - Lodi, New Jersey, United States, 07644
    - Arysmed LLC
  - Martinsville, New Jersey, United States, 08836
    - Amici Clinical Research, LLC
  - New Brunswick, New Jersey, United States, 08901
    - Rutgers Biomedical and Health Sciences-Robert Wood Johnson Medical School
  - Ridgewood, New Jersey, United States, 07450
    - The Valley Hospital
  - Ridgewood, New Jersey, United States, 07450
    - Cardiac and Endovascular Associates
  - Somerset, New Jersey, United States, 08873
    - Cardio Metabolic Institute
  - Trenton, New Jersey, United States, 08611
    - TLB Research LLC
  - Voorhees, New Jersey, United States, 08043
    - Lourdes Cardiology Services
  - Westwood, New Jersey, United States, 07675
    - Westwood Cardiology Associates
- New Mexico
  - Albuquerque, New Mexico, United States, 87102
    - Albuquerque Clinical Trials, Inc.
- New York
  - Albany, New York, United States, 12206
    - Albany Medical College, Division of Community Endocrinology
  - Brooklyn, New York, United States, 11235
    - NY Scientific
  - Brooklyn, New York, United States, 11214
    - Sorin Medical, P.C.
  - Brooklyn, New York, United States, 11215
    - NY Total Medical Care, PC
  - Buffalo, New York, United States, 14215
    - Buffalo Heart Group, LLP
  - Cortlandt Manor, New York, United States, 10567
    - NYU Hudson Valley Cardiology
  - Laurelton, New York, United States, 11413
    - Scott Research,Inc
  - Liverpool, New York, United States, 13088
    - SJH Cardiology Associates
  - Mineola, New York, United States, 11501
    - Long Island Heart Associates
  - New Windsor, New York, United States, 12553
    - Mid Hudson Medical Research, PLLC
  - New York, New York, United States, 10021
    - Weill Cornell Medical College
  - New York, New York, United States, 10016
    - Manhattan Medical Research Practice
  - New York, New York, United States, 10016
    - Peters Medical Research NY, LLC
  - North Massapequa, New York, United States, 11758-1802
    - DiGiovanna Institute for Medical Education And Research
  - Poughkeepsie, New York, United States, 12601
    - Hudson Valley Cardiovascular Practice, PC
  - Rochester, New York, United States, 14609
    - Rochester Clinical Research, Inc.
  - Rosedale, New York, United States, 11422
    - Institute for clinical studies
  - Saratoga Springs, New York, United States, 12866
    - Saratoga Clinical Research, LLC
  - Utica, New York, United States, 13501
    - Central New York Cardiology
  - Westfield, New York, United States, 14787
    - Great Lakes Medical Research
  - Williamsville, New York, United States, 14221
    - Buffalo Medical Group - Research Department
  - Williamsville, New York, United States, 14221
    - Buffalo Medical Group
- North Carolina
  - Burlington, North Carolina, United States, 27215
    - Kernodle Clinic, Department of the Private Diagnostic Clinic, PLLC
  - Charlotte, North Carolina, United States, 28204
    - Novant Health Heart and Vascular Institute
  - Charlotte, North Carolina, United States, 28209
    - PMG Research of Charlotte
  - Charlotte, North Carolina, United States, 28204
    - Novant Health Clinical Research
  - Charlotte, North Carolina, United States, 28277
    - Sensenbrenner Primary Care
  - Clayton, North Carolina, United States, 27520
    - NC Heart and Vascular
  - Greensboro, North Carolina, United States, 27401
    - LeBauer Cardiovascular Research Foundation
  - Hickory, North Carolina, United States, 28601
    - Clinical Trials of America, Inc.
  - High Point, North Carolina, United States, 27262
    - Carolina Cardiology Cornerstone
  - Lenoir, North Carolina, United States, 28645
    - Clinical Trials of America- NC, LLC
  - Mooresville, North Carolina, United States, 28117
    - Research Institute of the Carolinas of PiedmontHealthcare, PA
  - Morganton, North Carolina, United States, 28655
    - Burke Primary Care
  - New Bern, North Carolina, United States, 28562
    - Eastern Nephrology Associates
  - Rocky Mount, North Carolina, United States, 27804
    - Boice Willis Clinic
  - Rocky Mount, North Carolina, United States, 27804
    - PMG Research of Rock Mount, LLC - Patient Intake
  - Statesville, North Carolina, United States, 28625
    - Piedmont Healthcare/Research
  - Wilmington, North Carolina, United States, 28401
    - PMG Research of Wilmington, LLC
  - Winston-Salem, North Carolina, United States, 27157
    - Wake Forest University School of Medicine
- North Dakota
  - Fargo, North Dakota, United States, 58103
    - Lillestol Research LLC
- Ohio
  - Akron, Ohio, United States, 44311
    - Radiant Research, Inc.
  - Cincinnati, Ohio, United States, 45246
    - Sterling Research Group, Ltd.
  - Cincinnati, Ohio, United States, 45227
    - Metabolic and Atherosclerosis Research Center
  - Cincinnati, Ohio, United States, 45219
    - The Lindner Center for Research and Education at The Christ Hospital
  - Cleveland, Ohio, United States, 44122
    - Rapid Medical Research, Inc.
  - Cleveland, Ohio, United States, 44195
    - Cleveland Clinic - Taussig Cancer Institute
  - Columbus, Ohio, United States, 43235
    - Optimed Research, LTD
  - Columbus, Ohio, United States, 43212
    - Radiant Research, Inc.
  - Dayton, Ohio, United States, 45419
    - PriMed Clinical Research
  - Dayton, Ohio, United States, 45414
    - Premier Health Specialists, Inc (dba Dayton Heart Center)
  - Elyria, Ohio, United States, 44035
    - North Ohio Heart Center
  - Elyria, Ohio, United States, 44035
    - North Ohio Heart Center (Administrative Only)
  - Lorain, Ohio, United States, 44053
    - North Ohio Heart Center
  - Marion, Ohio, United States, 43302
    - SV Research, LLC
  - Perrysburg, Ohio, United States, 43551
    - Daniel G. Williams, Md
  - Sandusky, Ohio, United States, 44870
    - North Ohio Heart Center
  - Sandusky, Ohio, United States, 44870
    - North Ohio Heart Center, Inc.
  - Toledo, Ohio, United States, 43615
    - ProMedica Northwest Ohio Cardiology Consultants
  - Youngstown, Ohio, United States, 44501
    - Mercy Health Youngstown, LLC d/b/a St. Elizabeth Youngstown Hospital
- Oklahoma
  - Norman, Oklahoma, United States, 73072
    - Lion Research
  - Oklahoma City, Oklahoma, United States, 73120
    - Oklahoma Heart Hospital
  - Oklahoma City, Oklahoma, United States, 73135
    - South Oklahoma Heart Research, LLC
  - Oklahoma City, Oklahoma, United States, 73120
    - Oklahoma Heart Hospital Research Foundation
  - Oklahoma City, Oklahoma, United States, 73103
    - COR Clinical Research LLC
  - Oklahoma City, Oklahoma, United States, 73120
    - Oklahoma Heart Hospital Physicians
- Oregon
  - Ashland, Oregon, United States, 97520
    - Integrated Medical Research PC
  - Hillsboro, Oregon, United States, 97123
    - Hillsboro Cardiology, P.C.
  - Portland, Oregon, United States, 97225
    - Portland Preventive Cardiology LLC
- Pennsylvania
  - Abington, Pennsylvania, United States, 19001
    - Abington Memorial Hospital (administrative only)
  - Altoona, Pennsylvania, United States, 16602
    - Clinical Research Associates of Central PA
  - Downingtown, Pennsylvania, United States, 19335-2620
    - Brandywine Clinical Research
  - Doylestown, Pennsylvania, United States, 18901
    - Doylestown Cardiology Associates - VIAA
  - Doylestown, Pennsylvania, United States, 18901
    - Doylestown Health Cardiology, a division of Doylestown Health Physicians
  - Feasterville-Trevose, Pennsylvania, United States, 19053
    - Amh/Feasterville Family Health Care Center
  - Jefferson Hills, Pennsylvania, United States, 15025
    - Greater Pittsburgh Vascular
  - Lansdale, Pennsylvania, United States, 19446
    - Detweiler Family Medicine & Associates, PC
  - Lansdale, Pennsylvania, United States, 19446
    - Green and Seidner Family Practice Associates
  - Levittown, Pennsylvania, United States, 19056
    - Family Medical Associates
  - Newtown, Pennsylvania, United States, 18940
    - Mercer Bucks Cardiology
  - Philadelphia, Pennsylvania, United States, 19146
    - Philadelphia Health Associates-Adult Medicine
  - Pittsburgh, Pennsylvania, United States, 15236
    - Preferred Primary Care Physicians
  - Pittsburgh, Pennsylvania, United States, 15212
    - Allegheny Endocrinology Associates
  - Sayre, Pennsylvania, United States, 18840
    - Guthrie Medical Group, PC
  - Scotland, Pennsylvania, United States, 17254
    - SFM Clinical Trials, Inc.
  - Scottdale, Pennsylvania, United States, 15683
    - Fay-West Family Practice
  - Sellersville, Pennsylvania, United States, 18960
    - Grand View - Lehigh Valley Health Services, Buxmont Cardiology Division
  - Smithfield, Pennsylvania, United States, 15478
    - Montgomery Medical, Inc.
  - Uniontown, Pennsylvania, United States, 15401
    - Preferred Primary Care Physicians
  - Wyomissing, Pennsylvania, United States, 19610
    - Berks Cardiologists, Ltd.
- South Carolina
  - Charleston, South Carolina, United States, 29407
    - Coastal Cardiolgy
  - Greenville, South Carolina, United States, 29615
    - Upstate Pharmaceutical Research
  - Greer, South Carolina, United States, 29651
    - Mountain View Clinical Research, Inc.
- South Dakota
  - Rapid City, South Dakota, United States, 57701
    - Black Hills Cardiovascular-Regional Health Research
- Tennessee
  - Clarksville, Tennessee, United States, 37043
    - Mid-Cumberland Infectious Disease Consultants, PLC
  - Collierville, Tennessee, United States, 38017
    - Collierville Medical Specialists
  - Germantown, Tennessee, United States, 38138
    - Stern Cardiovascular Foundation, Inc.
  - Kingsport, Tennessee, United States, 37660
    - Holston Medical Group
  - Knoxville, Tennessee, United States, 37920
    - New Orleans Center for Clinical Research
  - Knoxville, Tennessee, United States, 37920
    - Volunteer Research Group
  - Knoxville, Tennessee, United States, 37909
    - New Phase Research & Development
  - Knoxville, Tennessee, United States, 37912
    - PMG Research,Inc d/b/a PMG Research of Knoxville
  - Knoxville, Tennessee, United States, 37917
    - Cardiovascular Research of Knoxville
  - Memphis, Tennessee, United States, 38119
    - Baptist Memorial Medical Group, Inc.
  - Memphis, Tennessee, United States, 38119
    - The Green Clinic, PC
  - Memphis, Tennessee, United States, 38125
    - Southwind Medical Specialists
  - Tullahoma, Tennessee, United States, 37388
    - Tennessee Center for Clinical Trials
  - Tullahoma, Tennessee, United States, 37388
    - Trinity Clinical Research, LLC
- Texas
  - Amarillo, Texas, United States, 79106
    - PharmaTex Research
  - Arlington, Texas, United States, 76012
    - Arlington Family Research Center, Inc.
  - Austin, Texas, United States, 78731
    - Texas Diabetes & Endocrinology
  - Austin, Texas, United States, 78756
    - Austin Heart, PLLC
  - Beaumont, Texas, United States, 77702
    - Southeast Texas Clinical Research Center
  - Beaumont, Texas, United States, 77702
    - Southeast Texas Cardiology Associates II, L.L.P.
  - Channelview, Texas, United States, 77530
    - Aztec Medical Research, LLC
  - Corsicana, Texas, United States, 75110
    - Corsicana Medical Research, PLLC
  - Dallas, Texas, United States, 75230
    - Dallas Diabetes and Endocrine Center
  - Dallas, Texas, United States, 75231
    - Research Institute of Dallas
  - Dallas, Texas, United States, 75235
    - Parkland Health and Hospital System
  - Dallas, Texas, United States, 75231
    - Cardiovascular Research Institute of Dallas
  - Dallas, Texas, United States, 75231
    - Radiant Research, Inc.
  - Dallas, Texas, United States, 75204
    - Baylor Research Institute IRB
  - Dallas, Texas, United States, 75208
    - Protenium Clinical Research, LLC
  - Dallas, Texas, United States, 75216
    - VA North Texas Health Care System - Dallas VAMC
  - Dallas, Texas, United States, 75226
    - Baylor Heart and Vascular Institute
  - Dallas, Texas, United States, 75246
    - Baylor University Medical Center / Department of Pharmacy
  - Dallas, Texas, United States, 75390-8565
    - University of Texas Southwestern Medical Center
  - Dallas, Texas, United States, 75390-9034
    - (For IP storage only)The University of Texas Southwestern Medical Center
  - Dallas, Texas, United States, 75390-9034
    - The University of Texas Southwestern Medical Center
  - Dallas, Texas, United States, 75390
    - William P. Clements Jr. University Hospital
  - Edinburg, Texas, United States, 78539
    - Doctors Hospital at Renaissance
  - Fort Worth, Texas, United States, 76164
    - Rockwood Medical Clinic
  - Fort Worth, Texas, United States, 76104
    - Amir Malik Research
  - Fort Worth, Texas, United States, 76104
    - The Medical Group Of Texas
  - Fort Worth, Texas, United States, 76117
    - T & R Clinic, PA
  - Georgetown, Texas, United States, 78626
    - San Gabriel Clinical Research, LLC
  - Houston, Texas, United States, 77030
    - Baylor College of Medicine
  - Houston, Texas, United States, 77058
    - Centex Studies, Inc.
  - Houston, Texas, United States, 77081
    - Texas Center for Drug Development, Inc
  - Houston, Texas, United States, 77030
    - Memorial Hermann Hospital, Texas Medical Center
  - Houston, Texas, United States, 77002
    - Spring Clinical Research
  - Houston, Texas, United States, 77030
    - Investigational Drug Services
  - Houston, Texas, United States, 77024
    - Prime Care Medical Group
  - Houston, Texas, United States, 77002
    - East Texas Cardiology PA
  - Houston, Texas, United States, 77024
    - Med Tech Research, LP
  - Houston, Texas, United States, 77027
    - Associates in Medicine, PA
  - Houston, Texas, United States, 77030
    - Alan S. Hoffman, M.D.
  - Houston, Texas, United States, 77030
    - ICTR/Baylor College of Medicine
  - Houston, Texas, United States, 77030
    - Memorial Hermann Hospital, Texas Medical Center- UT Health Clinical Research Unit
  - Houston, Texas, United States, 77030
    - The University of Texas Health Science Center at Houston- UT Physicians
  - Houston, Texas, United States, 77070
    - Northwest Houston Cardiology, P.A.
  - Houston, Texas, United States, 77094
    - Private Practice Leadership, LLC
  - Hurst, Texas, United States, 76054
    - Protenium Clinical Research LLC
  - Kerrville, Texas, United States, 78028
    - South Texas Cardiovascular Consultants, PLLC
  - Longview, Texas, United States, 75605
    - DCOL Center for Clinical Research
  - Lubbock, Texas, United States, 79410
    - Caprock Cardiac Center Research Institute Inc.
  - Midland, Texas, United States, 79707
    - Midland Clinical Research Center
  - New Braunfels, Texas, United States, 78130
    - Hill Country Medical Associates
  - North Richland Hills, Texas, United States, 76180
    - North Hills Medical Research, Inc.
  - Palestine, Texas, United States, 75801
    - Grace Research, LLC
  - Pasadena, Texas, United States, 77504
    - Med-Olam Clinical Research, LLC.
  - Pflugerville, Texas, United States, 78660
    - Austin Institute for Clinicla Research,Inc.
  - Pharr, Texas, United States, 78577
    - Centex Studies, Inc
  - San Antonio, Texas, United States, 78229
    - University of Texas Health Science Center San Antonio
  - San Antonio, Texas, United States, 78229
    - University of Texas Health Science Center at San Antonio
  - San Antonio, Texas, United States, 78215
    - Sun Research Institute
  - San Antonio, Texas, United States, 78229
    - University of Texas Health Sciences Center at San Antonio
  - San Antonio, Texas, United States, 78221
    - Southwest Clinic
  - San Antonio, Texas, United States, 78201
    - South Texas Cardiovascular Consultants, PLLC
  - San Antonio, Texas, United States, 78229
    - First Outpatient Research Unit
  - San Antonio, Texas, United States, 78231
    - Victorium Clinical Research
  - San Antonio, Texas, United States, 78249
    - Bandera Family Health Care, LLC
  - Schertz, Texas, United States, 78154
    - Northeast Clinical Research of San Antonio, LLC (NECRSA, LLC)
  - Sugar Land, Texas, United States, 77479
    - Sugar Lakes Family Practice
  - Sugar Land, Texas, United States, 77478
    - Acacia Medical Research Institute, LLC/Royal Oaks Medcical Home and Wellness Clinics
  - Sugar Land, Texas, United States, 77478
    - IP + Dry ice deliveries Sugar Lakes Family Practice
  - Tomball, Texas, United States, 77375-4536
    - Northwest Houston Heart Center
  - Tomball, Texas, United States, 77375
    - Northwest Heart Center
  - Tomball, Texas, United States, 77375
    - Admin & Storage only:Northwest Heart Center
  - Tomball, Texas, United States, 77375
    - Northwest Houston Clinical Research, PLLC
  - Victoria, Texas, United States, 77901
    - Victoria Heart & Vascular Center, PA
  - Victoria, Texas, United States, 77901
    - Victoria Heart and Vascular Center, PA
- Utah
  - Bountiful, Utah, United States, 84010
    - Utah Cardiology, PC
  - Layton, Utah, United States, 84041
    - Utah Cardiology, P.C.
  - Ogden, Utah, United States, 84405
    - Paramount Medical Care
  - Orem, Utah, United States, 84058
    - Aspen Clinical Research LLC
  - Provo, Utah, United States, 84604
    - Revere Health
  - Salt Lake City, Utah, United States, 84117
    - Holladay Family Practice
  - Salt Lake City, Utah, United States, 84107
    - Wasatch Clinical Research, LLC
  - Salt Lake City, Utah, United States, 84102
    - Optimum Clinical Research, Inc
  - Salt Lake City, Utah, United States, 84124
    - Heart Center at St. Mark's Hospital
- Virginia
  - Burke, Virginia, United States, 22015
    - Burke Internal Medicine & Research
  - Burke, Virginia, United States, 22015-4202
    - Clinical Research Institute of Northern Virginia
  - Falls Church, Virginia, United States, 22042
    - Virginia Heart
  - Falls Church, Virginia, United States, 22044
    - Seven Corners Medical Research Center
  - Hopewell, Virginia, United States, 23860
    - Heart Care Associates, P.C.
  - Midlothian, Virginia, United States, 23114
    - Virginia Research Center
  - Richmond, Virginia, United States, 23225
    - Chippenham and Johnston Willis Hospitals, Inc. dba CJW Medical Center
  - Richmond, Virginia, United States, 23225
    - Retreat Cardiology LLC, dba Cardiology Associates of Richmond
  - Roanoke, Virginia, United States, 24014
    - Roanoke Heart Institute
  - Suffolk, Virginia, United States, 23435
    - Hampton Roads Center for Clinical Research
- Washington
  - Burien, Washington, United States, 98166
    - The Office of Daniel W. Gottlieb, MD, PS
  - Spokane, Washington, United States, 99202
    - Premier Clinical Research
  - Tacoma, Washington, United States, 98405
    - Universal Research Group, LLC
  - Walla Walla, Washington, United States, 99362
    - Walla Walla Clinic
  - Wenatchee, Washington, United States, 98801
    - Wenatchee Valley Hospital & Clinics
- West Virginia
  - Fairmont, West Virginia, United States, 26554
    - Fairmont General Hospital
- Wisconsin
  - Green Bay, Wisconsin, United States, 54303
    - Prevea Clinic, Inc.
  - Kenosha, Wisconsin, United States, 53142
    - Clinical Investigation Specialists, Inc.
  - Waukesha, Wisconsin, United States, 53188
    - Waukesha Heart Foundation

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

16 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Genders Eligible for Study

All

Description

Inclusion Criteria:

Must be on background lipid lowering treatment.
Must be at high risk of a CV event.
Must have an LDL C >/=70 mg/dL (1.8 mmol/L) or non-HDL-C >/= 100 mg/dL (2.6 mmol/L).

Exclusion Criteria:

Planned coronary (PCI or CABG) or other arterial revascularization.
New York Heart Association Class IV congestive heart failure or left ventricular ejection fraction < 25% by cardiac imaging.
Chronic renal insufficiency with creatinine clearance of <30 ml/min/1.73m^2 by MDRD formula or with end state renal disease on dialysis.
History of hemorrhagic stroke.
Prior exposure to bococizumab or other investigational PCSK9 inhibitor.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Quadruple

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: bococizumab (PF-04950615) 150 mg, every 2 weeks, subcutaneous	Drug: bococizumab (PF-04950615) 150 mg, every 2 weeks, subcutaneous. The duration of the treatment period will depend upon reaching the targeted number of adjudicated and confirmed CV outcome events, approximately 3 to 4 years after the entry of first subject into the study. Other Names: RN316
Placebo Comparator: Placebo Placebo comparator, every 2 weeks, subcutaneous.	Drug: Placebo Placebo comparator, every 2 weeks, subcutaneous. The duration of the treatment period will depend upon reaching the targeted number of adjudicated and confirmed CV outcome events, approximately 3 to 4 years after the entry of first subject into the study.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Event Rate Per 100 Participant-Years For First Occurrence of Major Cardiovascular (CV) Event Time Frame: From baseline until the date of first adjudicated and confirmed occurrence of major CV event (maximum duration: up to 3.4 years)	Event rate per 100 participant-years for first occurrence of major CV event (adjudicated by Adjudication Committee) was reported. Major CV event was defined as any of the following: CV death (defined as sudden cardiac death, fatal myocardial infarction [MI], death due to heart failure, death due to stroke [fatal ischemic stroke or fatal stroke of undetermined etiology], or death due to other cardiovascular causes) non-fatal MI, non-fatal stroke, and hospitalization for unstable angina needing urgent revascularization. Event rate was calculated as the number of events per 100 participant-years at risk.	From baseline until the date of first adjudicated and confirmed occurrence of major CV event (maximum duration: up to 3.4 years)

Secondary Outcome Measures

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Pfizer

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

To obtain contact information for a study center near you, click here.

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 29, 2013

Primary Completion (Actual)

March 22, 2017

Study Completion (Actual)

March 22, 2017

Study Registration Dates

First Submitted

October 21, 2013

First Submitted That Met QC Criteria

October 28, 2013

First Posted (Estimate)

November 3, 2013

Study Record Updates

Last Update Posted (Actual)

July 11, 2018

Last Update Submitted That Met QC Criteria

June 14, 2018

Last Verified

June 1, 2018

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

B1481022
CV OUTCOMES 1
2013-002646-36 (EudraCT Number)
CV OUTCOMES 2 (Alias Study Number)

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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Study Overview

Status

Conditions

Intervention / Treatment

Detailed Description

Study Type

Enrollment (Actual)

Phase

Contacts and Locations

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Genders Eligible for Study

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Secondary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Collaborators and Investigators

Sponsor

Publications and helpful links

General Publications

Helpful Links

Study record dates

Study Major Dates

Study Start (Actual)

Primary Completion (Actual)

Study Completion (Actual)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Estimate)

Study Record Updates

Last Update Posted (Actual)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product

Clinical Trials on Cardiovascular Disease

Clinical Trials on bococizumab (PF-04950615)

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