A Study Comparing Cardiovascular Effects of Ticagrelor Versus Placebo in Patients With Type 2 Diabetes Mellitus (THEMIS)

A Multinational, Randomised, Double-Blind, Placebo-Controlled Trial to Evaluate the Effect of Ticagrelor Twice Daily on the Incidence of Cardiovascular Death, Myocardial Infarction or Stroke in Patients With Type 2 Diabetes Mellitus (THEMIS - Effect of Ticagrelor on Health Outcomes in Diabetes Mellitus Patients Intervention Study).

The purpose of this study is to compare the effect of ticagrelor versus placebo in patients with Type 2 Diabetes Mellitus.

Study Overview

• Status: Completed
• Conditions: Diabetes Mellitus, Type 2
• Intervention / Treatment: Drug: Ticagrelor 60 mg; Drug: Ticagrelor placebo

Detailed Description

A multinational, randomised, double-blind, placebo-controlled phase IIIb trial to evaluate the effect of ticagrelor twice daily on the incidence of cardiovascular death, myocardial infarction or stroke in patients with type 2 diabetes mellitus

• Study Type: Interventional
• Enrollment (Actual): 19271
• Phase: Phase 3

Contacts and Locations

Study Locations

• Argentina
  • Buenos Aires, Argentina, C1425AGC
    • Research Site
  • Buenos aires, Argentina, 1078
    • Research Site
  • Ciudad Autonomade Buenos Aires, Argentina, 1426
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  • Ciudad Autónoma de Bs. As., Argentina, C1199ABB
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  • Ciudadela, Argentina, 1702
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  • Cordoba, Argentina, 5000
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  • Cordoba, Argentina, X5000AAW
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  • Cordoba, Argentina, X5008HHW
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  • Mar del Plata, Argentina, 7600
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  • Mar del Plata, Argentina, B7600GNY
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  • Ranelagh, Argentina, 1886
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  • Rosario, Argentina, 2000
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  • Rosario, Argentina, S2000DNM
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  • Rosario, Argentina, S2000CVD
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  • San Luis, Argentina, 5700
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  • San Miguel de Tucuman, Argentina, 4000
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  • San Miguel de Tucuman, Argentina, T4000NIL
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  • San Nicolás, Argentina, B2900DMH
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  • Santa Fe, Argentina, S3000FWO
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  • Venado Tuerto, Argentina, 2600
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  • Villa Maria, Argentina, 5900
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• Australia
  • Adelaide, Australia, 5000
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  • Ashford, Australia, 5035
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  • Coffs Harbour, Australia, 2450
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  • Fitzroy, Australia, 3065
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  • Fullarton, Australia, 5063
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  • Geelong, Australia, 3220
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  • Heidelberg West, Australia, 3081
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  • Herston, Australia, 4029
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  • Joondalup, Australia, 6027
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  • Maroubra, Australia, 2035
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  • Melbourne, Australia, 3004
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  • Merewether, Australia, 2291
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  • Milton, Australia, 4064
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  • Murdoch, Australia, 6150
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• Austria
  • Braunau, Austria, 5280
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  • Eisenstadt, Austria, 7000
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  • Feldkirch, Austria, 6807
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  • Innsbruck, Austria, 6020
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  • Saint Stefan/Stainz, Austria, 8511
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  • Salzburg, Austria, 5020
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  • Vienna, Austria, 1010
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  • Wien, Austria, 1130
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  • Wien, Austria, 1090
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  • Wien, Austria, 1160
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  • Wien, Austria, 1030
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  • Wien, Austria, 1060
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• Belgium
  • Aalst, Belgium, 9300
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  • Bonheiden, Belgium, 2820
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  • Bouge, Belgium, 5004
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  • Bruges, Belgium, 8000
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  • De Pinte, Belgium, 9840
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  • Genk, Belgium, 3600
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  • Gent, Belgium, 9000
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  • Hasselt, Belgium, 3500
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  • Huy, Belgium, 4500
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  • Leuven, Belgium, 3000
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  • Liège, Belgium, 4000
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  • Mechelen, Belgium, 2800
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  • Mol, Belgium, 2400
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  • Overpelt, Belgium, 3900
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  • Roeselare, Belgium, 8800
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  • Yvoir, Belgium, 5530
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  • Zottegem, Belgium, 9620
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• Brazil
  • Belo Horizonte, Brazil, 30150-240
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  • Belo Horizonte, Brazil, 30110070
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  • Belo Horizonte, Brazil, 30190-130
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  • Blumenau, Brazil, 89010-906
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  • Brasilia, Brazil, 71625-175
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  • Brasillia, Brazil, 70200-730
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  • Brasillia, Brazil, 70710-100
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  • Brasília, Brazil, 70658-700
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  • Campina Grande do Sul, Brazil, 83430000
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  • Campinas, Brazil, 13010-001
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  • Campinas, Brazil, 13060 904
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  • Campo Grande, Brazil, 79080-190
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  • Cariacica, Brazil, 29156-580
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  • Curitiba, Brazil, 80230-130
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  • Curitiba, Brazil, 80730-150
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  • Curitiba, Brazil, 80320-320
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  • Fortaleza, Brazil, 60170-320
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  • Fortaleza, Brazil, 60120-021
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  • Fortaleza, Brazil, 60416-200
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  • Fortaleza, Brazil, 60864190
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  • Goiânia, Brazil, 74110-010
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  • Goiânia, Brazil, 74223-130
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  • Marilia, Brazil, 17515-000
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  • Maringa, Brazil, 87015-000
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  • Porto Alegre, Brazil, 90035-003
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  • Porto Alegre, Brazil, 90020-090
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  • Porto Alegre, Brazil, 90620-001
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  • Porto Alegre, Brazil, 90110-270
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  • Porto Alegre, Brazil, 91350200
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  • Ribeirão Preto, Brazil, 14048900
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  • Rio de Janeiro, Brazil, 22271-100
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  • S.J.Rio Preto, Brazil, 15090-000
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  • Sao Jose dos Campos, Brazil, 12243-280
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  • Sao Paulo, Brazil, 04266-010
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  • Sao Paulo, Brazil, 05403-000
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  • Sao Paulo, Brazil, 01228-200
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  • São Paulo, Brazil, 05403-000
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  • São Paulo, Brazil, 04012-180
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  • Tatui, Brazil, 18270-170
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  • Uberlândia, Brazil, 38400-368
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  • Vitoria, Brazil, 29047-575
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  • Vitória, Brazil, 29055-450
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  • Votuporanga, Brazil, 15500-003
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• Bulgaria
  • Blagoevgrad, Bulgaria, 2700
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  • Botevgrad, Bulgaria, 2140
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  • Burgas, Bulgaria, 8018
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  • Dimitrovgrad, Bulgaria, 6400
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  • Dupnitsa, Bulgaria, 2600
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  • Gabrovo, Bulgaria, 5300
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  • Haskovo, Bulgaria, 6300
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  • Kozloduy, Bulgaria, 3320
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  • Kyustendil, Bulgaria, 2500
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  • Lom, Bulgaria, 3600
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  • Pazardzhik, Bulgaria, 4400
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  • Pleven, Bulgaria, 5800
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  • Plovdiv, Bulgaria, 4003
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  • Plovdiv, Bulgaria, 4000
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  • Plovdiv, Bulgaria, 4002
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  • Russe, Bulgaria, 7003
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  • Sandanski, Bulgaria, 2800
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  • Sevlievo, Bulgaria, 5400
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  • Sliven, Bulgaria, 8800
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  • Sofia, Bulgaria, 1431
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  • Sofia, Bulgaria, 1407
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  • Sofia, Bulgaria, 1527
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  • Sofia, Bulgaria, 1233
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  • Sofia, Bulgaria, 1142
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  • Sofia, Bulgaria, 1606
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  • Sofia, Bulgaria, 1404
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  • Sofia, Bulgaria, 1463
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  • Sofia, Bulgaria, 1408
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  • Sofia, Bulgaria, 1709
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  • Sofia, Bulgaria, 1324
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  • Stara Zagora, Bulgaria, 6000
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  • Varna, Bulgaria, 9000
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  • Yambol, Bulgaria, 8600
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• Canada
  • Chicoutimi, Canada, G7H 5H6
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  • Quebec, Canada, G1G 3Y8
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  • Quebec, Canada, G1V 4G5
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  • Quebec, Canada, G1W 4R4
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  • Quebec, Canada, G2J 0C4
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  • Quebec, Canada, G1N 4V3
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  • Alberta
    • Calgary, Alberta, Canada, T2V 4J2
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    • Edmonton, Alberta, Canada, T5A 4L8
      • Research Site
    • Edmonton, Alberta, Canada, T5H 3V9
      • Research Site
    • Edmonton, Alberta, Canada, T6G 2E1
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    • Red Deer, Alberta, Canada, T4N 6V7
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    • Spruce Grove, Alberta, Canada, T7X 2V2
      • Research Site
  • British Columbia
    • Kelowna, British Columbia, Canada, V1Y 1V6
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    • New Westminster, British Columbia, Canada, V3L 3W4
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    • Penticton, British Columbia, Canada, V2A 5C8
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    • Surrey, British Columbia, Canada, V3V 0C6
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    • Vancouver, British Columbia, Canada, V5Z 1M9
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    • Victoria, British Columbia, Canada, V8R 4R2
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  • New Brunswick
    • Saint John, New Brunswick, Canada, E2L 4L2
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  • Newfoundland and Labrador
    • Mount Pearl, Newfoundland and Labrador, Canada, A1N 1W7
      • Research Site
    • St. John's, Newfoundland and Labrador, Canada, A1B 3V6
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    • St. John's, Newfoundland and Labrador, Canada, A1A 3R5
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  • Nova Scotia
    • Halifax, Nova Scotia, Canada, B3H 3A7
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    • Halifax, Nova Scotia, Canada, B3S 1M7
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  • Ontario
    • Brampton, Ontario, Canada, L6W 2X7
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    • Cambridge, Ontario, Canada, N1R 6V6
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    • Cambridge, Ontario, Canada, N1R 7R1
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    • Cambridge, Ontario, Canada, N1R 7L6
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    • Cornwall, Ontario, Canada, K6H 4M4
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    • Hamilton, Ontario, Canada, L8L 2X2
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    • Jarvis, Ontario, Canada, N0A 1J0
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    • London, Ontario, Canada, N6A 5A5
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    • London, Ontario, Canada, N6G 2M1
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    • Newmarket, Ontario, Canada, L3Y 5G8
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    • Newmarket, Ontario, Canada, L3Y 2R2
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    • North York, Ontario, Canada, M3M 3E5
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    • Oshawa, Ontario, Canada, L1J 2K1
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    • Ottawa, Ontario, Canada, K1Y 4W7
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    • Sarnia, Ontario, Canada, N7T 4X3
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    • Scarborough, Ontario, Canada, M1E 5E9
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    • Scarborough, Ontario, Canada, M1R 3A6
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    • Sudbury, Ontario, Canada, P3E 5M4
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    • Thornhill, Ontario, Canada, L4J 1W3
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    • Toronto, Ontario, Canada, M5G 2C4
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    • Toronto, Ontario, Canada, M5B 1W8
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    • Waterloo, Ontario, Canada, N2T 0C1
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  • Quebec
    • Brossard, Quebec, Canada, J4Z 2K9
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    • Chicoutimi, Quebec, Canada, G7H 7K9
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    • Greenfield Park, Quebec, Canada, J4V 2G8
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    • Laval, Quebec, Canada, H7T 2P5
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    • Laval, Quebec, Canada, H7M 3L9
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    • Longueuil, Quebec, Canada, J4M 2X1
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    • Montreal, Quebec, Canada, H1M 1B1
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    • Montreal, Quebec, Canada, H3G 1A4
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    • Montreal, Quebec, Canada, H1T 3Y7
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    • Montreal, Quebec, Canada, H2W 1T8
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    • Montréal, Quebec, Canada, H1T 1C8
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    • Saint-Charles-Borromee, Quebec, Canada, J6E 6J2
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    • Saint-Georges, Quebec, Canada, G5Y 4T8
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    • St Jean sur Richelieu, Quebec, Canada, J3A 1J2
      • Research Site
    • St-Lambert, Quebec, Canada, J4P 2H4
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    • Terrebonne, Quebec, Canada, J6V 2H2
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  • Saskatchewan
    • Regina, Saskatchewan, Canada, S4P 0W5
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• Chile
  • Concepcion, Chile, 4070060
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  • Los Angeles, Chile, 4430035
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  • Osorno, Chile, 5290000
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  • Santiago, Chile, 8360160
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  • Santiago, Chile, 8380456
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  • Santiago, Chile, 8207257
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  • Santiago, Chile, 8330034
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  • Santiago, Chile, 8910259
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  • Santiago, Chile, 7500021
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  • Santiago, Chile, 7980378
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  • Santiago, Chile, 7500520
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  • Santiago, Chile, 7500691
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  • Santiago, Chile, 7500701
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  • Talcahuano, Chile, 4270918
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  • Temuco, Chile, 4810371
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  • Viña del Mar, Chile, 2520997
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• China
  • Beijing, China, 100050
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  • Bengbu, China, 233060
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  • Cangzhou, China, 061001
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  • Chengdu, China, 610041
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  • Fuzhou, China, 350025
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  • Guangzhou, China, 510630
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  • Jinan, China, 250001
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  • Nanchang, China, 330006
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  • Nanjing, China, 210009
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  • Nanjing, China, 210012
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  • Nanjing, China, CN-210000
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  • Pingxiang, China, 337055
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  • Shanghai, China, 200032
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  • Shanghai, China, 200025
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  • Shanghai, China, 200065
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  • Shanghai, China, 200090
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  • Shenyang, China, 110016
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  • Taiyuan, China, 030001
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  • Tianjin, China, 300457
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  • Wuhan, China, CN-430022
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  • Xi'an, China, 710061
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  • Yinchuan, China, 750004
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• Colombia
  • Armenia, Colombia, 630004
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  • Barranquilla, Colombia, 80007
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  • Bogotá, Colombia
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  • Bucaramanga, Colombia
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  • Cali, Colombia
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  • Cali, Colombia, 76001000
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  • Cartagena, Colombia, 130001
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  • Floridablanca, Colombia, 681004
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  • Manizales, Colombia, 17001
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  • Medellin, Colombia, 050034
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  • Medellin, Colombia, 05001000
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  • Medellin, Colombia, 050015
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  • Medellín, Colombia
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• Czechia
  • Benesov, Czechia, 256 01
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  • Brno, Czechia, 602 00
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  • Brno, Czechia, 639 00
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  • Brno, Czechia, 62500
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  • Brno, Czechia, 638 00
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  • Ceska Lipa, Czechia, 470 77
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  • Chomutov, Czechia, 430 02
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  • Frydek-Mistek, Czechia, 738 01
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  • Jablonec nad Nisou, Czechia, 466 60
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  • Karlovy Vary, Czechia, 360 01
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  • Kolin, Czechia, 280 00
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  • Kutna Hora, Czechia, 284 30
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  • Louny, Czechia, 440 01
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  • Olomouc, Czechia, 772 52
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  • Ostrava, Czechia, 702 00
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  • Ostrava - Zabreh, Czechia, 700 30
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  • Ostrava-Dubina, Czechia, 700 30
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  • Pelhrimov, Czechia, 393 01
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  • Praha, Czechia, 110 00
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  • Praha, Czechia, 130 00
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  • Praha 10, Czechia, 10034
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  • Praha 2, Czechia, 12808
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  • Praha 5, Czechia, 150 06
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  • Praha 5, Czechia, 158 00
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  • Praha 5, Czechia, 150 00
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  • Praha 9, Czechia, 190 00
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  • Pribram VIII, Czechia, 260 01
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  • Slany, Czechia, 274 01
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  • Trebic, Czechia, 674 01
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  • Turnov, Czechia, 511 01
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  • Usti nad Labem, Czechia, 400 11
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  • Usti nad Orlici, Czechia, 562 18
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• Denmark
  • Aarhus N, Denmark, 8200
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  • Esbjerg, Denmark, 6700
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  • Hjørring, Denmark, 9800
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  • Hvidovre, Denmark, 2650
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  • Kolding, Denmark, 6000
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  • Købehhavn Ø, Denmark, 2100
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  • København NV, Denmark, 2400
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  • Næstved, Denmark, DK 4700
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  • Odense C, Denmark, 5000
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  • Roslev, Denmark, 7870
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  • Svendborg, Denmark, DK-5700
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  • Viborg, Denmark, 8800
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  • Værløse, Denmark, 3500
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• Finland
  • Helsinki, Finland, 00260
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  • Helsinki, Finland, 00180
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  • Joensuu, Finland, 80100
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  • Jyväskylä, Finland, 402 60
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  • Kokkola, Finland, 67100
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  • Kuopio, Finland, 70100
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  • Lahti, Finland, FI-15110
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  • Oulu, Finland, 90100
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  • Tampere, Finland, 33520
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  • Turku, Finland, 20100
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• France
  • Avignon Cedex, France, 84902
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  • Bayonne, France, 64100
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  • Bobigny, France, 93000
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  • Corbeil-Essonnes, France, 91100
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  • Dijon, France, 21079
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  • La Rochelle Cedex, France, 17019
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  • Le Coudray Cedex, France, 28630
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  • Lyon, France, 69007
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  • Montauban, France, 82017
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  • NICE Cedex 01, France, 06001
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  • Nimes, France, 30006
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  • PARIS Cedex 15, France, 75908
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  • Paris, France, 75877
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  • Paris, France, 75651
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  • TOURCOING cedex, France, 59208
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  • TOURS Cedex 9, France, 37044
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  • Toulouse Cedex, France, 31059
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• Germany
  • Altdorf, Germany, 90518
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  • Aschaffenburg, Germany, 63739
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  • Bad Krozingen, Germany, 79189
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  • Berlin, Germany, 10117
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  • Berlin, Germany, 10367
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  • Berlin, Germany, 10787
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  • Berlin, Germany, 13055
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  • Berlin, Germany, 10789
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  • Berlin, Germany, 13347
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  • Berlin, Germany, 13405
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  • Dresden, Germany, 01307
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  • Dresden, Germany, 01099
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  • Dresden, Germany, 01069
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  • Hamburg, Germany, 20253
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  • Hamburg, Germany, 22041
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  • Kassel, Germany, 34121
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  • Köln, Germany, 50397
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  • Leipzig, Germany, 04107
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  • Leipzig, Germany, 04315
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  • Markkleeberg, Germany, 04416
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  • Meißen, Germany, 01662
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  • Mühldorf Am Inn, Germany, 84453
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  • München, Germany, 80638
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  • Neuwied, Germany, 56564
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  • Nürnberg, Germany, 90402
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  • Papenburg, Germany, 26871
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  • Schwerin, Germany, 19055
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  • Wangen, Germany, 88239
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  • Wermsdorf, Germany, 04779
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• Hong Kong
  • Hong Kong, Hong Kong
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  • Hongkong, Hong Kong
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• Hungary
  • Balatonfüred, Hungary, 8230
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  • Berettyóújfalu, Hungary, 4100
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  • Budapest, Hungary, 1085
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  • Budapest, Hungary, 1115
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  • Budapest, Hungary, 1145
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  • Budapest, Hungary, 1076
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  • Budapest, Hungary, 1122
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  • Budapest, Hungary, 1135
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  • Budapest, Hungary, 1134
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  • Budapest, Hungary, 1096
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  • Budapest, Hungary, 1213
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  • Budapest, Hungary, 1032
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  • Budapest, Hungary, H-1106
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  • Debrecen, Hungary, 4032
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  • Eger, Hungary, 3300
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  • Hajdúszoboszló, Hungary, 4200
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  • Kalocsa, Hungary, 6300
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  • Kecskemét, Hungary, 6000
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  • Kistarcsa, Hungary, 2143
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  • Kisvárda, Hungary, 4600
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  • Mosonmagyaróvár, Hungary, 9200
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  • Nyíregyháza, Hungary, 4400
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  • Pásztó, Hungary, 3060
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  • Pécs, Hungary, 7623
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  • Sopron, Hungary, 9400
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  • Szentes, Hungary, 6600
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  • Szolnok, Hungary, 5000
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  • Székesfehérvár, Hungary, 8000
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  • Zalaegerszeg, Hungary, 8900
    • Research Site
• India
  • Ahmedabad, India, 380060
    • Research Site
  • Bangalore, India, 560002
    • Research Site
  • Bangalore, India, 560034
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  • Bangalore, India, 560069
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  • Chennai, India, 600081
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  • Kolkata, India, 700054
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  • Kolkata, India, 700027
    • Research Site
  • New Delhi, India, 110060
    • Research Site
  • New Delhi, India, 110002
    • Research Site
  • Pune, India, 411001
    • Research Site
  • Pune, India, 411011
    • Research Site
• Israel
  • Haifa, Israel, 34362
    • Research Site
  • Haifa, Israel, 31096
    • Research Site
  • Holon, Israel, 58100
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  • Jerusalem, Israel, 9103102
    • Research Site
  • Naharia, Israel, 22100
    • Research Site
  • Petach Tikva, Israel, 4937211
    • Research Site
  • Petah Tikva, Israel, 4941492
    • Research Site
  • Tel Aviv, Israel, 6423906
    • Research Site
• Italy
  • Bari, Italy, 70131
    • Research Site
  • Bergamo, Italy, 24128
    • Research Site
  • Bologna, Italy, 40139
    • Research Site
  • Bologna, Italy, 40100
    • Research Site
  • Firenze, Italy, 50141
    • Research Site
  • Genova, Italy, 16100
    • Research Site
  • Milano, Italy, 20132
    • Research Site
  • Milano, Italy, 20138
    • Research Site
  • Napoli, Italy, 80131
    • Research Site
  • Novara, Italy, 28100
    • Research Site
  • Pavia, Italy, 27100
    • Research Site
  • Rivoli, Italy, 10098
    • Research Site
  • Roma, Italy, 00152
    • Research Site
  • Roma, Italy, 00165
    • Research Site
  • San Giovanni Rotondo, Italy, 71013
    • Research Site
  • Udine, Italy, 33100
    • Research Site
  • Viterbo, Italy, 01100
    • Research Site
• Japan
  • Adachi-ku, Japan, 123-0845
    • Research Site
  • Beppu-shi, Japan, 874-0011
    • Research Site
  • Chikushino-shi, Japan, 818-8516
    • Research Site
  • Chuo-ku, Japan, 103-0027
    • Research Site
  • Daito-shi, Japan, 574-0074
    • Research Site
  • Edogawa-ku, Japan, 134-8678
    • Research Site
  • Fujisawa-shi, Japan, 251-0041
    • Research Site
  • Fukui-shi, Japan, 910-8526
    • Research Site
  • Fukuoka-shi, Japan, 810-8563
    • Research Site
  • Funabashi-shi, Japan, 274-0065
    • Research Site
  • Fussa-shi, Japan, 197-8511
    • Research Site
  • Gifu-shi, Japan, 500-8384
    • Research Site
  • Hachioji-shi, Japan, 192-0918
    • Research Site
  • Hitachi-shi, Japan, 317-0077
    • Research Site
  • Isehara-shi, Japan, 259-1193
    • Research Site
  • Iwakuni-shi, Japan, 740-8510
    • Research Site
  • Kagoshima-shi, Japan, 892-0853
    • Research Site
  • Kawanishi-shi, Japan, 666-0125
    • Research Site
  • Kishiwada-shi, Japan, 596-8522
    • Research Site
  • Kobe-shi, Japan, 651-0073
    • Research Site
  • Koga-shi, Japan, 811-3195
    • Research Site
  • Koriyama-shi, Japan, 963-8052
    • Research Site
  • Kumamoto-shi, Japan, 860-0008
    • Research Site
  • Kure-shi, Japan, 737-0023
    • Research Site
  • Kurume-shi, Japan, 830-0011
    • Research Site
  • Kyoto-shi, Japan, 612-8555
    • Research Site
  • Matsudo-shi, Japan, 271-0077
    • Research Site
  • Miura-gun, Japan, 240-0116
    • Research Site
  • Okayama-shi, Japan, 700-0804
    • Research Site
  • Osaka-shi, Japan, 554-0012
    • Research Site
  • Osaka-shi, Japan, 559-0012
    • Research Site
  • Otaru-shi, Japan, 047-8510
    • Research Site
  • Sanyoonoda-shi, Japan, 756-0095
    • Research Site
  • Sapporo-shi, Japan, 060-0031
    • Research Site
  • Sapporo-shi, Japan, 063-0005
    • Research Site
  • Sapporo-shi, Japan, 060-0033
    • Research Site
  • Sayama-shi, Japan, 350-1305
    • Research Site
  • Shimajiri-gun, Japan, 901-0493
    • Research Site
  • Takamatsu-shi, Japan, 760-0018
    • Research Site
  • Takasaki-shi, Japan, 370-0036
    • Research Site
  • Takasaki-shi, Japan, 370-3513
    • Research Site
  • Takayama-shi, Japan, 506-8550
    • Research Site
  • Toyohashi-shi, Japan, 440-8510
    • Research Site
  • Toyota-shi, Japan, 471-8513
    • Research Site
  • Tsuchiura-shi, Japan, 300-0053
    • Research Site
  • Uji-shi, Japan, 611-0041
    • Research Site
  • Urasoe-shi, Japan, 901-2132
    • Research Site
  • Ureshino-shi, Japan, 843-0393
    • Research Site
  • Wakayama-shi, Japan, 649-6335
    • Research Site
  • Wako-shi, Japan, 351-0102
    • Research Site
  • Yokohama-shi, Japan, 236-0051
    • Research Site
  • Yokohama-shi, Japan, 247-8581
    • Research Site
• Korea, Republic of
  • Anyang-si, Korea, Republic of, 431-070
    • Research Site
  • Bucheon-si, Korea, Republic of, 14754
    • Research Site
  • Busan, Korea, Republic of, 49241
    • Research Site
  • Busan, Korea, Republic of, 47392
    • Research Site
  • Changwon-si, Korea, Republic of, 51353
    • Research Site
  • Cheonan-si, Korea, Republic of, 330-715
    • Research Site
  • Cheongju-si, Korea, Republic of, 362-804
    • Research Site
  • Daegu, Korea, Republic of, 42601
    • Research Site
  • Daegu, Korea, Republic of, 42415
    • Research Site
  • Daegu, Korea, Republic of, 41944
    • Research Site
  • Daejeon, Korea, Republic of, 301-721
    • Research Site
  • Gwangju, Korea, Republic of, 61469
    • Research Site
  • Iksan-si, Korea, Republic of, 54538
    • Research Site
  • Incheon, Korea, Republic of, 405-760
    • Research Site
  • Jeonju-si, Korea, Republic of, 561-712
    • Research Site
  • Jinju-si, Korea, Republic of, 660-702
    • Research Site
  • Seongnam-si, Korea, Republic of, 13620
    • Research Site
  • Seoul, Korea, Republic of, 03080
    • Research Site
  • Seoul, Korea, Republic of, 135-710
    • Research Site
  • Seoul, Korea, Republic of, 02841
    • Research Site
  • Seoul, Korea, Republic of, 06591
    • Research Site
  • Seoul, Korea, Republic of, 08308
    • Research Site
  • Seoul, Korea, Republic of, 130-872
    • Research Site
  • Seoul, Korea, Republic of, 110-746
    • Research Site
  • Suwon-si, Korea, Republic of, 16499
    • Research Site
  • Wonju-si, Korea, Republic of, 26426
    • Research Site
• Mexico
  • Culiacan, Mexico, 80020
    • Research Site
  • Culiacán, Mexico, 80200
    • Research Site
  • D.F, Mexico, 14000
    • Research Site
  • Guadalajara, Mexico, 44670
    • Research Site
  • Guadalajara, Mexico, 44676
    • Research Site
  • Guadalajara, Mexico, 44340
    • Research Site
  • Mexico, Mexico, 06700
    • Research Site
  • Monterey, Mexico, 64060
    • Research Site
  • Monterrey, Mexico, 64460
    • Research Site
  • Monterrey, Mexico, 64020
    • Research Site
  • Monterrey, Mexico, 66465
    • Research Site
  • Morelia, Mexico, 58260
    • Research Site
  • México, Mexico, 14080
    • Research Site
  • Nuevo Leon, Mexico, 64060
    • Research Site
  • Pachuca, Mexico, 42070
    • Research Site
  • Querétaro, Mexico, 76000
    • Research Site
  • Tijuana, Mexico, 22014
    • Research Site
  • Xalapa, Mexico, 91193
    • Research Site
  • Zapopan, Mexico, 45200
    • Research Site
• Netherlands
  • Alkmaar, Netherlands, 1815 JD
    • Research Site
  • Amsterdam, Netherlands, 1091 AC
    • Research Site
  • Amsterdam, Netherlands, 1061 AE
    • Research Site
  • Arnhem, Netherlands, 6815 AD
    • Research Site
  • Beverwijk, Netherlands, 1942 LE
    • Research Site
  • Blaricum, Netherlands, 1261 AN
    • Research Site
  • Breda, Netherlands, 4818 CK
    • Research Site
  • Delft, Netherlands, 2625 AD
    • Research Site
  • Den Bosch, Netherlands, 5223 GZ
    • Research Site
  • Eindhoven, Netherlands, 5623 EJ
    • Research Site
  • Emmen, Netherlands, 7824 AA
    • Research Site
  • Enschede, Netherlands, 7512 KZ
    • Research Site
  • Goes, Netherlands, 4462 RA
    • Research Site
  • Helmond, Netherlands, 5707 HA
    • Research Site
  • Hoofddorp, Netherlands, 2134 TM
    • Research Site
  • Hoogeveen, Netherlands, 7909 AA
    • Research Site
  • Maastricht, Netherlands, 6202 AZ
    • Research Site
  • Roosendaal, Netherlands, 4708 AE
    • Research Site
  • Rotterdam, Netherlands, 3045 PM
    • Research Site
  • Schiedam, Netherlands, 3118 JH
    • Research Site
  • Stadskanaal, Netherlands, 9501 HE
    • Research Site
  • Tiel, Netherlands, 4002 WP
    • Research Site
  • Uden, Netherlands, 5406 PT
    • Research Site
  • Veldhoven, Netherlands, 5504 DB
    • Research Site
• Norway
  • Bergen, Norway, N-5009
    • Research Site
  • Bodø, Norway, N-8092
    • Research Site
  • Bodø, Norway, NO8008
    • Research Site
  • Kongsvinger, Norway, N-2212
    • Research Site
  • Lillehammer, Norway, N-2629
    • Research Site
  • Oslo, Norway, 0372
    • Research Site
  • Oslo, Norway, N-0953
    • Research Site
  • Oslo, Norway, NO-1157
    • Research Site
  • Sandefjord, Norway, N-3211
    • Research Site
  • Skedsmokorset, Norway, N-2020
    • Research Site
  • Skien, Norway, N-3710
    • Research Site
  • Stavanger, Norway, N-4011
    • Research Site
  • Svelvik, Norway, N-3060
    • Research Site
  • Tromsø, Norway, N-9038
    • Research Site
  • Trondheim, Norway, N-7462
    • Research Site
  • Ålesund, Norway, N-6003
    • Research Site
• Peru
  • Arequipa, Peru, 04000
    • Research Site
  • Callao, Peru, CALLAO 2
    • Research Site
  • Callao, Peru, CALLAO 02
    • Research Site
  • Chiclayo, Peru, 14000
    • Research Site
  • Lima, Peru, LIMA 27
    • Research Site
  • Lima, Peru, LIMA 41
    • Research Site
  • Lima, Peru, 14
    • Research Site
  • Lima, Peru, LIMA 01
    • Research Site
  • Lima, Peru, 31
    • Research Site
  • Lima, Peru, Lima 32
    • Research Site
  • Lima, Peru, L41
    • Research Site
  • Lima, Peru, L11
    • Research Site
  • Lima, Peru, L33
    • Research Site
  • Miraflores, Peru, 15046
    • Research Site
• Philippines
  • Cebu, Philippines, 6000
    • Research Site
  • Cebu City, Philippines, 6000
    • Research Site
  • Davao City, Philippines, PH-8000
    • Research Site
  • Pasig City, Philippines, 1600
    • Research Site
  • Quezon City, Philippines, 1104
    • Research Site
  • Quezon City, Philippines, 1101
    • Research Site
  • Taguig City, Philippines, 1634
    • Research Site
• Poland
  • Biała Rawska, Poland, 96-230
    • Research Site
  • Białystok, Poland, 15-276
    • Research Site
  • Białystok, Poland, 15-351
    • Research Site
  • Białystok, Poland, 15-875
    • Research Site
  • Bielsko-Biała, Poland, 43-316
    • Research Site
  • Bochnia, Poland, 32-700
    • Research Site
  • Bydgoszcz, Poland, 85-796
    • Research Site
  • Bydgoszcz, Poland, 85-231
    • Research Site
  • Bydgoszcz, Poland, 85-079
    • Research Site
  • Chojnice, Poland, 89-600
    • Research Site
  • Chorzów, Poland, 41-500
    • Research Site
  • Chrzanow, Poland, 32-500
    • Research Site
  • Chrzanów, Poland, 32-500
    • Research Site
  • Elbląg, Poland, 82-300
    • Research Site
  • Gdańsk, Poland, 80-952
    • Research Site
  • Gdańsk, Poland, 80-286
    • Research Site
  • Gdańsk, Poland, 80-546
    • Research Site
  • Gdańsk, Poland, 80-437
    • Research Site
  • Gdynia, Poland, 81-157
    • Research Site
  • Gdynia, Poland, 81-423
    • Research Site
  • Gdynia, Poland, 81-472
    • Research Site
  • Giżycko, Poland, 11-500
    • Research Site
  • Grodzisk Mazowiecki, Poland, 05-825
    • Research Site
  • Jasło, Poland, 38-200
    • Research Site
  • Katowice, Poland, 40-752
    • Research Site
  • Katowice, Poland, 40-081
    • Research Site
  • Katowice, Poland, 40-748
    • Research Site
  • Kielce, Poland, 25-525
    • Research Site
  • Koszalin, Poland, 75-256
    • Research Site
  • Kościan, Poland, 64-000
    • Research Site
  • Kraków, Poland, 31-559
    • Research Site
  • Kraków, Poland, 31-202
    • Research Site
  • Kraków, Poland, 31-156
    • Research Site
  • Kędzierzyn Koźle, Poland, 47-200
    • Research Site
  • Legnica, Poland, 59-220
    • Research Site
  • Lubin, Poland, 59-301
    • Research Site
  • Lublin, Poland, 20-362
    • Research Site
  • Lublin, Poland, 20-538
    • Research Site
  • Lublin, Poland, 20-709
    • Research Site
  • Lublin, Poland, 20-044
    • Research Site
  • Mikołów, Poland, 43-190
    • Research Site
  • Myszków, Poland, 42-300
    • Research Site
  • Nakło nad Notecią, Poland, 89-100
    • Research Site
  • Nowogard, Poland, 72-200
    • Research Site
  • Nysa, Poland, 48-300
    • Research Site
  • Opole, Poland, 45-056
    • Research Site
  • Ostrów Mazowiecka, Poland, 07-300
    • Research Site
  • Oświęcim, Poland, 32-600
    • Research Site
  • Poznań, Poland, 61-655
    • Research Site
  • Poznań, Poland, 60-821
    • Research Site
  • Puławy, Poland, 24-100
    • Research Site
  • Płock, Poland, 09-402
    • Research Site
  • Ruda Slaska, Poland, 41-709
    • Research Site
  • Rzeszów, Poland, 35-205
    • Research Site
  • Rzeszów, Poland, 35-055
    • Research Site
  • Siedlce, Poland, 08-110
    • Research Site
  • Sobótka, Poland, 55-050
    • Research Site
  • Sokółka, Poland, 16-100
    • Research Site
  • Staszów, Poland, 28-200
    • Research Site
  • Szczecin, Poland, 70-506
    • Research Site
  • Szczecin, Poland, 71-531
    • Research Site
  • Tarnów, Poland, 33-100
    • Research Site
  • Torun, Poland, 87-100
    • Research Site
  • Toruń, Poland, 87-100
    • Research Site
  • Tychy, Poland, 43-100
    • Research Site
  • Ustroń, Poland, 43-450
    • Research Site
  • Warszawa, Poland, 02-097
    • Research Site
  • Warszawa, Poland, 04-628
    • Research Site
  • Warszawa, Poland, 02-679
    • Research Site
  • Warszawa, Poland, 05-077
    • Research Site
  • Wierzchosławice, Poland, 33-122
    • Research Site
  • Wrocław, Poland, 50-127
    • Research Site
  • Wrocław, Poland, 50-555
    • Research Site
  • Włocławek, Poland, 87-800
    • Research Site
  • Zabrze, Poland, 41-800
    • Research Site
  • Zamość, Poland, 22-400
    • Research Site
  • Zgierz, Poland, 95-100
    • Research Site
  • Zielona Góra, Poland, 65-036
    • Research Site
  • Łódź, Poland, 94-238
    • Research Site
  • Żnin, Poland, 88-400
    • Research Site
• Puerto Rico
  • Canovanas, Puerto Rico, 00729
    • Research Site
  • Cidra, Puerto Rico, 00739
    • Research Site
• Romania
  • Bacau, Romania, 600114
    • Research Site
  • Bucharest, Romania, 050098
    • Research Site
  • Bucharest, Romania, 061118
    • Research Site
  • Bucuresti, Romania, 020054
    • Research Site
  • Craiova, Romania, 200642
    • Research Site
  • Craiova, Romania, 200147
    • Research Site
  • Iasi, Romania, 700304
    • Research Site
  • Iasi, Romania, 700620
    • Research Site
  • Pitesti, Romania, 110084
    • Research Site
  • Suceava, Romania, 720284
    • Research Site
• Russian Federation
  • Arkhangelsk, Russian Federation, 163001
    • Research Site
  • Ekaterinburg, Russian Federation, 620039
    • Research Site
  • Ekaterinburg, Russian Federation, 620043
    • Research Site
  • Gatchina, Russian Federation, 188300
    • Research Site
  • Ivanovo, Russian Federation, 153012
    • Research Site
  • Izhevsk, Russian Federation, 426063
    • Research Site
  • Kaluga, Russian Federation, 248010
    • Research Site
  • Kazan, Russian Federation, 420012
    • Research Site
  • Kazan, Russian Federation, 420103
    • Research Site
  • Kazan, Russian Federation, 420043
    • Research Site
  • Kemerovo, Russian Federation, 650000
    • Research Site
  • Kemerovo, Russian Federation, 650002
    • Research Site
  • Khanty-Mansiysk, Russian Federation, 628012
    • Research Site
  • Krasnodar, Russian Federation, 350012
    • Research Site
  • Krasnodar, Russian Federation, 350086
    • Research Site
  • Krasnodar, Russian Federation, 350042
    • Research Site
  • Moscow, Russian Federation, 119991
    • Research Site
  • Moscow, Russian Federation, 117997
    • Research Site
  • Moscow, Russian Federation, 121552
    • Research Site
  • Moscow, Russian Federation, 125284
    • Research Site
  • Moscow, Russian Federation, 109263
    • Research Site
  • Moscow, Russian Federation, 129327
    • Research Site
  • Moscow, Russian Federation, 117556
    • Research Site
  • Moscow, Russian Federation, 121374
    • Research Site
  • Moscow, Russian Federation, 121309
    • Research Site
  • Moscow, Russian Federation, 115516
    • Research Site
  • Moscow, Russian Federation, 117292
    • Research Site
  • Moscow, Russian Federation, 121359
    • Research Site
  • Moscow, Russian Federation, 119121
    • Research Site
  • Moscow, Russian Federation, 105187
    • Research Site
  • Nizhniy Novgorod, Russian Federation, 603076
    • Research Site
  • Novosibirsk, Russian Federation, 630008
    • Research Site
  • Novosibirsk, Russian Federation, 630055
    • Research Site
  • Novosibirsk, Russian Federation, 630099
    • Research Site
  • Omsk, Russian Federation, 644043
    • Research Site
  • Omsk, Russian Federation, 644112
    • Research Site
  • Omsk, Russian Federation, 644111
    • Research Site
  • Perm, Russian Federation, 614000
    • Research Site
  • Perm, Russian Federation, 6144090
    • Research Site
  • Perm, Russian Federation, 614068
    • Research Site
  • Rostov-na-Donu, Russian Federation, 344068
    • Research Site
  • Ryazan, Russian Federation, 390026
    • Research Site
  • Ryazan, Russian Federation, 390039
    • Research Site
  • Saint Petersburg, Russian Federation, 194044
    • Research Site
  • Saint Petersburg, Russian Federation, 196601
    • Research Site
  • Saint Petersburg, Russian Federation, 194156
    • Research Site
  • Saint Petersburg, Russian Federation, 198412
    • Research Site
  • Saint- Petersburg, Russian Federation, 192148
    • Research Site
  • Saint-Petersburg, Russian Federation, 196143
    • Research Site
  • Saint-Petersburg, Russian Federation, 195067
    • Research Site
  • Saint-Petersburg, Russian Federation, 199106
    • Research Site
  • Saint-Petersburg, Russian Federation, 192242
    • Research Site
  • Saint-Petersburg, Russian Federation, 194354
    • Research Site
  • Saint-Petersburg, Russian Federation, 194156
    • Research Site
  • Saratov, Russian Federation, 410039
    • Research Site
  • St Petersburg, Russian Federation, 197341
    • Research Site
  • St. Petersburg, Russian Federation, 194017
    • Research Site
  • St.Petersburg, Russian Federation, 195030
    • Research Site
  • St.Petersburg, Russian Federation, 198013
    • Research Site
  • StPetersburg, Russian Federation, 193312
    • Research Site
  • Tomsk, Russian Federation, 634012
    • Research Site
  • Tver, Russian Federation, 170036
    • Research Site
  • Tyumen, Russian Federation, 625000
    • Research Site
  • Tyumen, Russian Federation, 625026
    • Research Site
  • Ufa, Russian Federation, 450071
    • Research Site
  • Vladimir, Russian Federation, 600023
    • Research Site
  • Volgograd, Russian Federation, 400131
    • Research Site
  • Yaroslavl, Russian Federation, 150062
    • Research Site
• Saudi Arabia
  • Dammam, Saudi Arabia, 31444
    • Research Site
  • Dammam, Saudi Arabia, 31463
    • Research Site
  • Jeddah, Saudi Arabia, 21499
    • Research Site
  • Khobar, Saudi Arabia, 34445
    • Research Site
  • Riyadh, Saudi Arabia, 11426
    • Research Site
  • Riyadh, Saudi Arabia, 11525
    • Research Site
  • Riyadh, Saudi Arabia, 12371
    • Research Site
  • Riyadh, Saudi Arabia, 1121
    • Research Site
• Slovakia
  • Banska Bystrica, Slovakia, 974 05
    • Research Site
  • Bratislava, Slovakia, 841 08
    • Research Site
  • Brezno, Slovakia, 97742
    • Research Site
  • Kosice, Slovakia, 040 01
    • Research Site
  • Kosice, Slovakia, 04022
    • Research Site
  • Kralovsky Chlmec, Slovakia, 077 01
    • Research Site
  • Liptovsky Mikulas, Slovakia, 031 01
    • Research Site
  • Lucenec, Slovakia, 984 01
    • Research Site
  • Martin, Slovakia, 036 01
    • Research Site
  • Nitra, Slovakia, 949 01
    • Research Site
  • Presov, Slovakia, 080 01
    • Research Site
  • Ruzomberok, Slovakia, 034 26
    • Research Site
  • Svidnik, Slovakia, 08901
    • Research Site
  • Trnava, Slovakia, 917 01
    • Research Site
  • Zilina, Slovakia, 010 01
    • Research Site
• South Africa
  • Alberton, South Africa, 1450
    • Research Site
  • Benoni, South Africa, 1500
    • Research Site
  • Bloemfontein, South Africa, 9301
    • Research Site
  • Cape Town, South Africa, 7570
    • Research Site
  • Cape Town, South Africa, 1730
    • Research Site
  • Cape Town, South Africa, 7500
    • Research Site
  • Cape Town, South Africa, 7405
    • Research Site
  • Cape Town, South Africa, 7460
    • Research Site
  • Cape Town, South Africa, 7550
    • Research Site
  • Durban, South Africa, 4001
    • Research Site
  • Durban, South Africa, 4170
    • Research Site
  • Durban, South Africa, 4052
    • Research Site
  • Greenbury, Phoenix, South Africa, 4068
    • Research Site
  • Johannesburg, South Africa, 2193
    • Research Site
  • Johannesburg, South Africa, 2132
    • Research Site
  • Paarl, South Africa, 7646
    • Research Site
  • Port Elizabeth, South Africa, 6001
    • Research Site
  • Soweto, South Africa, 2013
    • Research Site
  • Stanger, South Africa, 4450
    • Research Site
  • Verulam, South Africa, 4345
    • Research Site
  • Worcester, South Africa, 6830
    • Research Site
• Spain
  • A Coruña, Spain, 15006
    • Research Site
  • Alcalá de Henares, Spain, 28805
    • Research Site
  • Alicante, Spain, 03010
    • Research Site
  • Barcelona, Spain, 08035
    • Research Site
  • Barcelona, Spain, 08036
    • Research Site
  • Barcelona, Spain, 08041
    • Research Site
  • Barcelona, Spain, 08003
    • Research Site
  • Barcelona, Spain, 08022
    • Research Site
  • Bilbao, Spain, 48013
    • Research Site
  • Cáceres, Spain, 10003
    • Research Site
  • El Palmar, Spain, 30120
    • Research Site
  • Ferrol (A Coruña), Spain, 15405
    • Research Site
  • Girona, Spain, 17007
    • Research Site
  • Granada, Spain, 18012
    • Research Site
  • Hospitalet de Llobregat, Spain, 08907
    • Research Site
  • Huelva, Spain, 21005
    • Research Site
  • La Laguna (Tenerife), Spain, 38320
    • Research Site
  • Madrid, Spain, 28031
    • Research Site
  • Madrid, Spain, 28034
    • Research Site
  • Madrid, Spain, 28041
    • Research Site
  • Madrid, Spain, 28040
    • Research Site
  • Madrid, Spain, 28006
    • Research Site
  • Madrid, Spain, 28007
    • Research Site
  • Majadahonda, Spain, 28222
    • Research Site
  • Málaga, Spain, 29010
    • Research Site
  • Móstoles, Spain, 28933
    • Research Site
  • Pontevedra, Spain, 36312
    • Research Site
  • Sabadell, Spain, 08208
    • Research Site
  • San Juan de Alicante, Spain, 03550
    • Research Site
  • San Sebastian de los Reyes, Spain, 28702
    • Research Site
  • Santander, Spain, 39008
    • Research Site
  • Santiago(A Coruña), Spain, 15706
    • Research Site
  • Sevilla, Spain, 41014
    • Research Site
  • Sevilla, Spain, 41071
    • Research Site
  • Son Ferriol, Spain, 07198
    • Research Site
  • Valdemoro, Spain, 28342
    • Research Site
  • Valencia, Spain, 46010
    • Research Site
• Sweden
  • Göteborg, Sweden, 413 45
    • Research Site
  • Jönköping, Sweden, 551 85
    • Research Site
  • Lessebo, Sweden, 365 32
    • Research Site
  • Lund, Sweden, 222 21
    • Research Site
  • Lund, Sweden, 222 42
    • Research Site
  • Malmö, Sweden, 205 02
    • Research Site
  • Rättvik, Sweden, 79530
    • Research Site
  • Stockholm, Sweden, 141 86
    • Research Site
  • Stockholm, Sweden, 118 83
    • Research Site
  • Stockholm, Sweden, 182 88
    • Research Site
  • Stockholm, Sweden, 112 81
    • Research Site
  • Uppsala, Sweden, 75185
    • Research Site
  • Västerås, Sweden, 721 89
    • Research Site
  • Örebro, Sweden, 703 62
    • Research Site
• Taiwan
  • Changhua City, Taiwan, 50006
    • Research Site
  • Hsinchu, Taiwan, 300
    • Research Site
  • Hualien City, Taiwan, 970
    • Research Site
  • Kaohsiung, Taiwan
    • Research Site
  • Kaohsiung, Taiwan, 80756
    • Research Site
  • Kaohsiung, Taiwan, 81362
    • Research Site
  • Kaohsiung City, Taiwan, 83301
    • Research Site
  • Kweishan Shiang, Taiwan, 333
    • Research Site
  • New Taipei City, Taiwan, 220
    • Research Site
  • New Taipei City, Taiwan, 25160
    • Research Site
  • Pingtung, Taiwan, 928
    • Research Site
  • Taichung, Taiwan, 40705
    • Research Site
  • Taichung, Taiwan
    • Research Site
  • Taichung, Taiwan, 40201
    • Research Site
  • Tainan, Taiwan, 704
    • Research Site
  • Tainan, Taiwan, 710
    • Research Site
  • Tainan, Taiwan, 70965
    • Research Site
  • Taipei, Taiwan
    • Research Site
  • Taipei, Taiwan, 10449
    • Research Site
  • Taipei, Taiwan, 11217
    • Research Site
  • Taipei, Taiwan, 11101
    • Research Site
• Thailand
  • Bangkok, Thailand, 10330
    • Research Site
  • Bangkok, Thailand, 10400
    • Research Site
  • Bangkoknoi, Thailand, 10700
    • Research Site
  • Chiang Mai, Thailand, 50200
    • Research Site
  • Hat Yai, Thailand, 90110
    • Research Site
  • Muang, Thailand, 40002
    • Research Site
  • Naimuang, Thailand, 30000
    • Research Site
• Turkey
  • Adana, Turkey, 01130
    • Research Site
  • Ankara, Turkey, 06230
    • Research Site
  • Ankara, Turkey, 06100
    • Research Site
  • Ankara, Turkey, 06330
    • Research Site
  • Antalya, Turkey, 07059
    • Research Site
  • Antalya, Turkey, 07100
    • Research Site
  • Aydin, Turkey, 09010
    • Research Site
  • Istanbul, Turkey
    • Research Site
  • Istanbul, Turkey, 34093
    • Research Site
  • Istanbul, Turkey, 34200
    • Research Site
  • Istanbul, Turkey, 34303
    • Research Site
  • Mersin, Turkey
    • Research Site
  • İstanbul, Turkey, 34304
    • Research Site
• Ukraine
  • Belo Horizonte, Ukraine, 30110025
    • Research Site
  • Cherkasy, Ukraine, 18009
    • Research Site
  • Dnipro, Ukraine, 49027
    • Research Site
  • Dnipro, Ukraine, 49064
    • Research Site
  • Dnipro, Ukraine, 49070
    • Research Site
  • Ivano-Frankivsk, Ukraine, 76018
    • Research Site
  • Ivano-Frankivsk, Ukraine, 76005
    • Research Site
  • Kharkiv Region, Ukraine, 61039
    • Research Site
  • Kharkiv Region, Ukraine, 61176
    • Research Site
  • Kharkiv Region, Ukraine, 61058
    • Research Site
  • Kharkiv Region, Ukraine, 61002
    • Research Site
  • Kharkiv Region, Ukraine, 61018
    • Research Site
  • Kyiv, Ukraine, 01601
    • Research Site
  • Kyiv, Ukraine, 04050
    • Research Site
  • Kyiv, Ukraine, 04114
    • Research Site
  • Kyiv, Ukraine, 02002
    • Research Site
  • Kyiv, Ukraine, 02091
    • Research Site
  • Kyiv, Ukraine, 02660
    • Research Site
  • Kyiv, Ukraine, 03680
    • Research Site
  • Kyiv, Ukraine, 03110
    • Research Site
  • Kyiv, Ukraine, 03151
    • Research Site
  • Kyiv, Ukraine, 04053
    • Research Site
  • Kyiv, Ukraine, 01014
    • Research Site
  • Lutsk, Ukraine, 43024
    • Research Site
  • Lviv, Ukraine, 79010
    • Research Site
  • Lviv, Ukraine, 79015
    • Research Site
  • Mykolaiv, Ukraine, 54003
    • Research Site
  • Odesa, Ukraine, 65114
    • Research Site
  • Odesa, Ukraine, 65025
    • Research Site
  • Odesa, Ukraine, 65082
    • Research Site
  • Poltava, Ukraine, 36038
    • Research Site
  • Rivne, Ukraine, 33007
    • Research Site
  • Ternopil, Ukraine, 46010
    • Research Site
  • Uzhhorod, Ukraine, 88014
    • Research Site
  • Vinnytsia, Ukraine, 21018
    • Research Site
  • Vinnytsia, Ukraine, 21021
    • Research Site
  • Vinnytsia, Ukraine, 21005
    • Research Site
  • Zaporizhzhia, Ukraine, 69600
    • Research Site
  • Zaporizhzhia, Ukraine, 69068
    • Research Site
• United Kingdom
  • Airdrie, United Kingdom, ML6 0JS
    • Research Site
  • Antrim, United Kingdom, BT41 2RL
    • Research Site
  • Belfast, United Kingdom, BT63 5QQ
    • Research Site
  • Chesterfield, United Kingdom, S40 4AA
    • Research Site
  • Coventry, United Kingdom, CV2 2DX
    • Research Site
  • Doncaster, United Kingdom, DN9 2HY
    • Research Site
  • Dundee, United Kingdom, DD1 9SY
    • Research Site
  • Durham, United Kingdom, DH1 5TW
    • Research Site
  • Exeter, United Kingdom, EX2 5DW
    • Research Site
  • Faringdon, United Kingdom, SN7 7YU
    • Research Site
  • Glasgow, United Kingdom, G12 8TA
    • Research Site
  • Harrogate, United Kingdom
    • Research Site
  • High Wycombe, United Kingdom, HP11 2TT
    • Research Site
  • London, United Kingdom, EC1M 6BQ
    • Research Site
  • Middlesborough, United Kingdom, TS4 3BW
    • Research Site
  • Newcastle-Upon-Tyne, United Kingdom, NE7 7DN
    • Research Site
  • Northampton, United Kingdom, NN1 5BD
    • Research Site
  • Nottingham, United Kingdom, NG5 1PB
    • Research Site
  • Paisley, United Kingdom, PA2 9PN
    • Research Site
  • Peterborough, United Kingdom, PE3 9GZ
    • Research Site
  • Plymouth, United Kingdom, PL6 8BX
    • Research Site
  • Rotherham, United Kingdom, S60 2UD
    • Research Site
  • Rothwell, United Kingdom, NN14 6JQ
    • Research Site
  • Sheffield, United Kingdom, S5 7AU
    • Research Site
  • Swansea, United Kingdom, SA2 8QA
    • Research Site
  • Torquay, United Kingdom, TQ2 7AA
    • Research Site
  • York, United Kingdom, YO31 8HE
    • Research Site
• United States
  • Alabama
    • Alexander City, Alabama, United States, 35010
      • Research Site
    • Birmingham, Alabama, United States, 35211
      • Research Site
    • Fairhope, Alabama, United States, 36532
      • Research Site
    • Huntsville, Alabama, United States, 35801
      • Research Site
    • Huntsville, Alabama, United States, 35803
      • Research Site
    • Mobile, Alabama, United States, 36608
      • Research Site
    • Montgomery, Alabama, United States, 36111
      • Research Site
    • Sheffield, Alabama, United States, 35660
      • Research Site
    • Tuscumbia, Alabama, United States, 35674
      • Research Site
  • Arizona
    • Cottonwood, Arizona, United States, 86326
      • Research Site
    • Glendale, Arizona, United States, 85306
      • Research Site
    • Tucson, Arizona, United States, 85741
      • Research Site
  • Arkansas
    • Little Rock, Arkansas, United States, 72205
      • Research Site
    • Little Rock, Arkansas, United States, 72211
      • Research Site
    • Little Rock, Arkansas, United States, 72204
      • Research Site
  • California
    • Anaheim, California, United States, 92801
      • Research Site
    • Bakersfield, California, United States, 93309
      • Research Site
    • Beverly Hills, California, United States, 90211
      • Research Site
    • Fremont, California, United States, 94538
      • Research Site
    • Fresno, California, United States, 93721
      • Research Site
    • Irvine, California, United States, 92614
      • Research Site
    • La Mesa, California, United States, 91942
      • Research Site
    • Long Beach, California, United States, 90806
      • Research Site
    • Long Beach, California, United States, 90807
      • Research Site
    • Los Alamitos, California, United States, 90720
      • Research Site
    • Los Angeles, California, United States, 90036
      • Research Site
    • Los Angeles, California, United States, 90033
      • Research Site
    • Los Angeles, California, United States, 90067
      • Research Site
    • Mission Hills, California, United States, 91345
      • Research Site
    • Newport Beach, California, United States, 92663
      • Research Site
    • Sacramento, California, United States, 95821
      • Research Site
    • San Diego, California, United States, 92103
      • Research Site
    • San Diego, California, United States, 92122
      • Research Site
    • Stanford, California, United States, 94305-5235
      • Research Site
    • Stockton, California, United States, 95204
      • Research Site
    • Tarzana, California, United States, 91356
      • Research Site
    • Torrance, California, United States, 90509
      • Research Site
  • Colorado
    • Denver, Colorado, United States, 80239-3133
      • Research Site
  • Connecticut
    • Bridgeport, Connecticut, United States, 06610
      • Research Site
    • Greenwich, Connecticut, United States, 06830
      • Research Site
  • Florida
    • Bradenton, Florida, United States, 34209
      • Research Site
    • Clearwater, Florida, United States, 33756
      • Research Site
    • Cooper City, Florida, United States, 33024
      • Research Site
    • Coral Springs, Florida, United States, 33065
      • Research Site
    • Crystal River, Florida, United States, 34429
      • Research Site
    • Cutler Bay, Florida, United States, 33189
      • Research Site
    • Daytona Beach, Florida, United States, 32114
      • Research Site
    • DeLand, Florida, United States, 32720
      • Research Site
    • Fort Lauderdale, Florida, United States, 33312
      • Research Site
    • Hialeah, Florida, United States, 33012
      • Research Site
    • Hialeah, Florida, United States, 33013
      • Research Site
    • Hollywood, Florida, United States, 33021
      • Research Site
    • Jacksonville, Florida, United States, 32209
      • Research Site
    • Jacksonville, Florida, United States, 32204
      • Research Site
    • Jacksonville, Florida, United States, 32216
      • Research Site
    • Lake Worth, Florida, United States, 33467
      • Research Site
    • Largo, Florida, United States, 33707
      • Research Site
    • Merritt Island, Florida, United States, 32953
      • Research Site
    • Miami, Florida, United States, 33126
      • Research Site
    • Miami, Florida, United States, 33173
      • Research Site
    • Miami, Florida, United States, 33186
      • Research Site
    • Miami, Florida, United States, 33165
      • Research Site
    • Miami, Florida, United States, 33176
      • Research Site
    • Miami, Florida, United States, 33136
      • Research Site
    • Miami, Florida, United States, 33134
      • Research Site
    • Miami, Florida, United States, 33144
      • Research Site
    • Miami, Florida, United States, 33135
      • Research Site
    • Miami, Florida, United States, 33155
      • Research Site
    • Miami, Florida, United States, 33174
      • Research Site
    • Miami, Florida, United States, 33166
      • Research Site
    • Miami Gardens, Florida, United States, 33169
      • Research Site
    • Miami Shores, Florida, United States, 33012
      • Research Site
    • Miami Springs, Florida, United States, 33166
      • Research Site
    • Naples, Florida, United States, 34102
      • Research Site
    • New Smyrna Beach, Florida, United States, 32169
      • Research Site
    • North Miami Beach, Florida, United States, 33162
      • Research Site
    • Ocala, Florida, United States, 34471
      • Research Site
    • Ormond Beach, Florida, United States, 32174
      • Research Site
    • Panama City, Florida, United States, 32401
      • Research Site
    • Port Charlotte, Florida, United States, 33952
      • Research Site
    • Saint Cloud, Florida, United States, 34769
      • Research Site
  • Georgia
    • Atlanta, Georgia, United States, 30322
      • Research Site
    • Columbus, Georgia, United States, 31904
      • Research Site
    • Cumming, Georgia, United States, 30041
      • Research Site
    • Decatur, Georgia, United States, 30012
      • Research Site
    • Decatur, Georgia, United States, 30032
      • Research Site
    • Gainesville, Georgia, United States, 30501
      • Research Site
    • Tucker, Georgia, United States, 30084
      • Research Site
  • Idaho
    • Nampa, Idaho, United States, 83687
      • Research Site
  • Illinois
    • Arlington Heights, Illinois, United States, 60005
      • Research Site
    • Chicago, Illinois, United States, 60654
      • Research Site
    • Chicago, Illinois, United States, 60631
      • Research Site
    • Crystal Lake, Illinois, United States, 60012
      • Research Site
    • Elmhurst, Illinois, United States, 60126
      • Research Site
    • Evanston, Illinois, United States, 60201
      • Research Site
    • Gurnee, Illinois, United States, 60031
      • Research Site
    • Hinsdale, Illinois, United States, 60521
      • Research Site
    • Moline, Illinois, United States, 61265
      • Research Site
    • North Chicago, Illinois, United States, 60064
      • Research Site
    • Peoria, Illinois, United States, 61614
      • Research Site
  • Indiana
    • Anderson, Indiana, United States, 46011
      • Research Site
    • Elkhart, Indiana, United States, 46514
      • Research Site
    • Fort Wayne, Indiana, United States, 46845
      • Research Site
    • Greenfield, Indiana, United States, 46140
      • Research Site
    • Indianapolis, Indiana, United States, 46227
      • Research Site
    • Indianapolis, Indiana, United States, 460202
      • Research Site
    • Muncie, Indiana, United States, 47303
      • Research Site
    • Muncie, Indiana, United States, 47304
      • Research Site
    • Munster, Indiana, United States, 46321
      • Research Site
  • Iowa
    • Davenport, Iowa, United States, 52803
      • Research Site
    • West Des Moines, Iowa, United States, 50265
      • Research Site
  • Kansas
    • Wichita, Kansas, United States, 67214
      • Research Site
  • Kentucky
    • Crestview Hills, Kentucky, United States, 41017
      • Research Site
    • Owensboro, Kentucky, United States, 42303
      • Research Site
  • Louisiana
    • Alexandria, Louisiana, United States, 71301
      • Research Site
    • Bossier City, Louisiana, United States, 71111
      • Research Site
    • Covington, Louisiana, United States, 70433
      • Research Site
    • Crowley, Louisiana, United States, 70526
      • Research Site
    • Minden, Louisiana, United States, 71055
      • Research Site
    • Monroe, Louisiana, United States, 71201
      • Research Site
    • Shreveport, Louisiana, United States, 71103
      • Research Site
    • Shreveport, Louisiana, United States, 71105
      • Research Site
    • Slidell, Louisiana, United States, 70458
      • Research Site
  • Maine
    • Auburn, Maine, United States, 04210
      • Research Site
    • Bangor, Maine, United States, 04401
      • Research Site
  • Maryland
    • Baltimore, Maryland, United States, 21218
      • Research Site
    • Baltimore, Maryland, United States, 21215-5271
      • Research Site
    • Bowie, Maryland, United States, 20715
      • Research Site
    • Glen Burnie, Maryland, United States, 21061
      • Research Site
    • Greenbelt, Maryland, United States, 20770
      • Research Site
    • Oxon Hill, Maryland, United States, 20745
      • Research Site
    • Prince Frederick, Maryland, United States, 20678
      • Research Site
    • Salisbury, Maryland, United States, 21804
      • Research Site
  • Massachusetts
    • Haverhill, Massachusetts, United States, 01830
      • Research Site
    • North Attleboro, Massachusetts, United States, 02760
      • Research Site
  • Michigan
    • Detroit, Michigan, United States, 48202
      • Research Site
    • Jackson, Michigan, United States, 49201
      • Research Site
    • Kalamazoo, Michigan, United States, 49009
      • Research Site
    • Mount Clemens, Michigan, United States, 48043
      • Research Site
    • Petoskey, Michigan, United States, 49770
      • Research Site
    • Pontiac, Michigan, United States, 48341
      • Research Site
    • Rochester Hills, Michigan, United States, 48307
      • Research Site
    • Troy, Michigan, United States, 48098
      • Research Site
  • Minnesota
    • Duluth, Minnesota, United States, 55805
      • Research Site
    • Saint Paul, Minnesota, United States, 55102
      • Research Site
  • Mississippi
    • Biloxi, Mississippi, United States, 39531
      • Research Site
    • Jackson, Mississippi, United States, 39216
      • Research Site
    • Olive Branch, Mississippi, United States, 38654
      • Research Site
    • Tupelo, Mississippi, United States, 38801
      • Research Site
  • Missouri
    • Joplin, Missouri, United States, 64804
      • Research Site
    • Kansas City, Missouri, United States, 64111
      • Research Site
    • Kansas City, Missouri, United States, 64108
      • Research Site
    • Lee's Summit, Missouri, United States, 64064
      • Research Site
    • North Kansas City, Missouri, United States, 64116
      • Research Site
    • Saint Louis, Missouri, United States, 63110
      • Research Site
    • Saint Louis, Missouri, United States, 63136
      • Research Site
    • Saint Louis, Missouri, United States, 63128
      • Research Site
  • Montana
    • Helena, Montana, United States, 59601
      • Research Site
  • Nebraska
    • Hastings, Nebraska, United States, 68901
      • Research Site
    • Lincoln, Nebraska, United States, 68506
      • Research Site
    • Lincoln, Nebraska, United States, 68526
      • Research Site
  • Nevada
    • Las Vegas, Nevada, United States, 89128
      • Research Site
  • New Jersey
    • Bridgewater, New Jersey, United States, 08807
      • Research Site
    • East Brunswick, New Jersey, United States, 08816
      • Research Site
    • Flemington, New Jersey, United States, 08822
      • Research Site
    • Morristown, New Jersey, United States, 08057
      • Research Site
    • Somerset, New Jersey, United States, 08873
      • Research Site
    • Toms River, New Jersey, United States, 08755
      • Research Site
    • Voorhees, New Jersey, United States, 08043
      • Research Site
  • New Mexico
    • Albuquerque, New Mexico, United States, 87102
      • Research Site
  • New York
    • Albany, New York, United States, 12203
      • Research Site
    • Binghamton, New York, United States, 13901
      • Research Site
    • Bronx, New York, United States, 10467
      • Research Site
    • Buffalo, New York, United States, 14215
      • Research Site
    • Hawthorne, New York, United States, 10532
      • Research Site
    • Manhasset, New York, United States, 11030
      • Research Site
    • New Windsor, New York, United States, 12553
      • Research Site
    • New York, New York, United States, 10029
      • Research Site
    • New York, New York, United States, 10001
      • Research Site
    • Orchard Park, New York, United States, 14127
      • Research Site
    • Poughkeepsie, New York, United States, 12601
      • Research Site
    • Saratoga Springs, New York, United States, 12866
      • Research Site
    • Stony Brook, New York, United States, 11794-8167
      • Research Site
    • Utica, New York, United States, 13501
      • Research Site
  • North Carolina
    • Asheville, North Carolina, United States, 28803
      • Research Site
    • Calabash, North Carolina, United States, 28467
      • Research Site
    • Cary, North Carolina, United States, 27518
      • Research Site
    • Clayton, North Carolina, United States, 27520
      • Research Site
    • High Point, North Carolina, United States, 27265
      • Research Site
    • Lenoir, North Carolina, United States, 28645
      • Research Site
    • Morganton, North Carolina, United States, 28655
      • Research Site
    • Pinehurst, North Carolina, United States, 28374
      • Research Site
    • Raleigh, North Carolina, United States, 27610
      • Research Site
    • Rocky Mount, North Carolina, United States, 27804
      • Research Site
    • Sanford, North Carolina, United States, 27330
      • Research Site
    • Smithfield, North Carolina, United States, 27577
      • Research Site
    • Tabor City, North Carolina, United States, 28463
      • Research Site
    • Winston-Salem, North Carolina, United States, 27103
      • Research Site
  • North Dakota
    • Fargo, North Dakota, United States, 58104
      • Research Site
    • Fargo, North Dakota, United States, 58103
      • Research Site
  • Ohio
    • Akron, Ohio, United States, 44302
      • Research Site
    • Canton, Ohio, United States, 44710
      • Research Site
    • Cincinnati, Ohio, United States, 45227
      • Research Site
    • Cleveland, Ohio, United States, 44122
      • Research Site
    • Cleveland, Ohio, United States, 44126
      • Research Site
    • Dayton, Ohio, United States, 45419
      • Research Site
    • Kettering, Ohio, United States, 45429
      • Research Site
    • Lyndhurst, Ohio, United States, 44124
      • Research Site
    • Springfield, Ohio, United States, 45504
      • Research Site
    • Willoughby, Ohio, United States, 44094
      • Research Site
    • Youngstown, Ohio, United States, 44501
      • Research Site
  • Oklahoma
    • Oklahoma City, Oklahoma, United States, 73104
      • Research Site
    • Oklahoma City, Oklahoma, United States, 73103
      • Research Site
    • Oklahoma City, Oklahoma, United States, 73129
      • Research Site
  • Oregon
    • Hillsboro, Oregon, United States, 97123-4117
      • Research Site
    • Medford, Oregon, United States, 97504
      • Research Site
  • Pennsylvania
    • Butler, Pennsylvania, United States, 16001
      • Research Site
    • Camp Hill, Pennsylvania, United States, 17011
      • Research Site
    • Danville, Pennsylvania, United States, 17822
      • Research Site
    • Doylestown, Pennsylvania, United States, 18901
      • Research Site
    • Erie, Pennsylvania, United States, 16502
      • Research Site
    • Harleysville, Pennsylvania, United States, 19438
      • Research Site
    • Indiana, Pennsylvania, United States, 15701
      • Research Site
    • Newport, Pennsylvania, United States, 17074
      • Research Site
    • Philadelphia, Pennsylvania, United States, 19141
      • Research Site
    • Pittsburgh, Pennsylvania, United States, 15240
      • Research Site
    • Port Matilda, Pennsylvania, United States, 16870
      • Research Site
    • Scranton, Pennsylvania, United States, 18510
      • Research Site
    • Wyomissing, Pennsylvania, United States, 19610
      • Research Site
    • Yardley, Pennsylvania, United States, 19067
      • Research Site
  • Rhode Island
    • Providence, Rhode Island, United States, 02903
      • Research Site
    • Providence, Rhode Island, United States, 02906
      • Research Site
  • South Carolina
    • Columbia, South Carolina, United States, 29204
      • Research Site
    • Columbia, South Carolina, United States, 29205
      • Research Site
    • Columbia, South Carolina, United States, 29209-1639
      • Research Site
    • Greenwood, South Carolina, United States, 29646
      • Research Site
    • North Myrtle Beach, South Carolina, United States, 29582
      • Research Site
    • Rock Hill, South Carolina, United States, 29732
      • Research Site
    • Simpsonville, South Carolina, United States, 29681
      • Research Site
    • Varnville, South Carolina, United States, 29924
      • Research Site
  • South Dakota
    • Rapid City, South Dakota, United States, 57701
      • Research Site
    • Sioux Falls, South Dakota, United States, 57108
      • Research Site
  • Tennessee
    • Bristol, Tennessee, United States, 37620
      • Research Site
    • Jackson, Tennessee, United States, 38305
      • Research Site
    • Knoxville, Tennessee, United States, 37934
      • Research Site
    • Knoxville, Tennessee, United States, 37917
      • Research Site
    • Nashville, Tennessee, United States, 37204
      • Research Site
    • Tullahoma, Tennessee, United States, 37388
      • Research Site
  • Texas
    • Amarillo, Texas, United States, 79106
      • Research Site
    • Arlington, Texas, United States, 76012
      • Research Site
    • Austin, Texas, United States, 78705
      • Research Site
    • Austin, Texas, United States, 78709
      • Research Site
    • Beaumont, Texas, United States, 77702
      • Research Site
    • Channelview, Texas, United States, 77530
      • Research Site
    • Dallas, Texas, United States, 75231
      • Research Site
    • Dallas, Texas, United States, 75216
      • Research Site
    • Dallas, Texas, United States, 75390-9184
      • Research Site
    • Fort Sam Houston, Texas, United States, 78234
      • Research Site
    • Fort Worth, Texas, United States, 76107
      • Research Site
    • Fort Worth, Texas, United States, 76116
      • Research Site
    • Georgetown, Texas, United States, 78626
      • Research Site
    • Houston, Texas, United States, 77090
      • Research Site
    • Houston, Texas, United States, 77058
      • Research Site
    • Houston, Texas, United States, 77070
      • Research Site
    • Houston, Texas, United States, 77024
      • Research Site
    • Houston, Texas, United States, 77025
      • Research Site
    • Houston, Texas, United States, 77043
      • Research Site
    • Houston, Texas, United States, 77036
      • Research Site
    • Houston, Texas, United States, 77062
      • Research Site
    • Huntsville, Texas, United States, 77340
      • Research Site
    • Katy, Texas, United States, 77450
      • Research Site
    • Kingwood, Texas, United States, 77339
      • Research Site
    • Lubbock, Texas, United States, 79430
      • Research Site
    • McAllen, Texas, United States, 78503
      • Research Site
    • Pharr, Texas, United States, 78577
      • Research Site
    • Plano, Texas, United States, 75093
      • Research Site
    • Plano, Texas, United States, 75024
      • Research Site
    • San Antonio, Texas, United States, 78231
      • Research Site
    • San Antonio, Texas, United States, 78224
      • Research Site
    • Shavano Park, Texas, United States, 78231
      • Research Site
  • Utah
    • Bountiful, Utah, United States, 84010
      • Research Site
    • Draper, Utah, United States, 84020
      • Research Site
    • Salt Lake City, Utah, United States, 84124
      • Research Site
  • Virginia
    • Alexandria, Virginia, United States, 22304
      • Research Site
    • Arlington, Virginia, United States, 22205
      • Research Site
    • Danville, Virginia, United States, 24541
      • Research Site
    • Falls Church, Virginia, United States, 22042
      • Research Site
    • Manassas, Virginia, United States, 20110
      • Research Site
    • Manassas, Virginia, United States, 20109
      • Research Site
    • Roanoke, Virginia, United States, 24014
      • Research Site
  • Washington
    • Port Orchard, Washington, United States, 98366
      • Research Site
    • Seattle, Washington, United States, 98104
      • Research Site
  • West Virginia
    • Huntington, West Virginia, United States, 25701
      • Research Site
  • Wisconsin
    • Kenosha, Wisconsin, United States, 53144
      • Research Site
    • Waukesha, Wisconsin, United States, 53188
      • Research Site
• Vietnam
  • Hanoi, Vietnam
    • Research Site
  • Hcmc, Vietnam, 700000
    • Research Site
  • Ho Chi Minh, Vietnam
    • Research Site
  • Ho Chi Minh, Vietnam, 70000
    • Research Site
  • Hochiminh, Vietnam, 70000
    • Research Site

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 50 years to 130 years (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

Men or women ≥50 years of age with type 2 diabetes mellitus on treatment with a glucose lowering medication since at least 6 months, and either documented coronary artery occlusive disease or previous revascularization of a coronary artery.

Key Exclusion Criteria:

History of myocardial infarction or any stroke; planned treatment with agents inhibiting blood clotting; planned use of ASA/Aspirin at doses above 150 mg daily; planned coronary, cerebrovascular, or peripheral arterial revascularization; patients with known bleeding disorders and patients who need chronic oral anticoagulant therapy or chronic low-molecular-weight heparin; history of intracranial bleeding at any time, or a history of bleeding from the gastrointestinal tract within the last 6 months or a major surgery within the last 30 days; patients with known severe liver disease or with kidney failure requiring dialysis

Study Plan

How is the study designed?

Design Details

• Primary Purpose: PREVENTION
• Allocation: RANDOMIZED
• Interventional Model: PARALLEL
• Masking: QUADRUPLE

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
EXPERIMENTAL: Ticagrelor 60 mg; Initially ticagrelor 90 mg or corresponding placebo was the selected dose, but reduced to ticagrelor 60 mg or corresponding placebo in Clinical Study Protocol Amendment No 1.	Drug: Ticagrelor 60 mg; Ticagrelor 60 mg bd taken orally as tablets; Other Names: Brilinta/Brilique
PLACEBO_COMPARATOR: Ticagrelor placebo; Initially ticagrelor 90 mg or corresponding placebo was the selected dose, but reduced to ticagrelor 60 mg or corresponding placebo in Clinical Study Protocol Amendment No 1.	Drug: Ticagrelor placebo; Ticagrelor placebo bd taken orally as tablets

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Composite of Cardiovascular (CV) Death, MI or Stroke	Participants with Cardiovascular (CV) death, myocardial infarction (MI) or stroke. If no event, censoring occurs at the earliest of PACD, last endpoint assessment date and non-CV death date.	From randomisation to primary analysis censoring date (PACD). Median time in study until PACD was 40 months.

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
CV Death	Participants with Cardiovascular (CV) death. If no event, censoring occurs at the earliest of PACD, last endpoint assessment date and non-CV death date.	From randomisation to primary analysis censoring date (PACD). Median time in study until PACD was 40 months.
MI	Participants with myocardial infarction. If no event, censoring occurs at the earliest of primary analysis censoring date (PACD), last endpoint assessment date and death date	From randomisation to primary analysis censoring date (PACD). Median time in study until PACD was 40 months.
Ischaemic Stroke	Participants with ischaemic stroke. If no event, censoring occurs at the earliest of PACD, last endpoint assessment date and death date.	From randomisation to primary analysis censoring date (PACD). Median time in study until PACD was 40 months.
All-cause Death	Participants with all-cause death. If no event, censoring occurs at the earliest of PACD and last endpoint assessment date. Includes deaths based on publically available vital status data in patients who have withdrawn consent.	From randomisation to primary analysis censoring date (PACD). Median time in study until PACD was 40 months.

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
TIMI Major Bleeding Event (Primary Safety Objective)	Participants with TIMI major bleeding event. If no event, censoring occurs at the earliest of last endpoint assessment date, death date and 7 days following the date of last dose of study medication	From randomisation to 7 days following the date of last dose of study medication. Maximum duration of exposure was 59 months.
TIMI Major or Minor Bleeding Event	Participants with TIMI major or minor bleeding event. If no event, censoring occurs at the earliest of last endpoint assessment date, death date and 7 days following the date of last dose of study medication	From randomisation to 7 days following the date of last dose of study medication. Maximum duration of exposure was 59 months.
PLATO Major Bleeding Event	Participants with PLATO major bleeding event. If no event, censoring occurs at the earliest of last endpoint assessment date, death date and 7 days following the date of last dose of study medication	From randomisation to 7 days following the date of last dose of study medication. Maximum duration of exposure was 59 months.
Permanent Discontinuation of Study Medication Due to Any Bleeding Event	Participants with permanent discontinuation of study medication due to any bleeding event. If no event, censoring occurs at the earliest of last endpoint assessment date, death date and the date of last dose of study medication	From randomisation to 7 days following the date of last dose of study medication. Maximum duration of exposure was 59 months.

Collaborators and Investigators

• Sponsor: AstraZeneca
• Investigators: Principal Investigator: Philippe Gabriel Steg, MD, Hôpital Bichat-Claude Bernard 46 Rue Henri Huchard, Paris; Principal Investigator: Deepak L. Bhatt, MD, Brigham and Women's Hospital75 Francis Street, Boston

Publications and helpful links

General Publications

• Steg PG, Bhatt DL, Simon T, Fox K, Mehta SR, Harrington RA, Held C, Andersson M, Himmelmann A, Ridderstrale W, Leonsson-Zachrisson M, Liu Y, Opolski G, Zateyshchikov D, Ge J, Nicolau JC, Corbalan R, Cornel JH, Widimsky P, Leiter LA; THEMIS Steering Committee and Investigators. Ticagrelor in Patients with Stable Coronary Disease and Diabetes. N Engl J Med. 2019 Oct 3;381(14):1309-1320. doi: 10.1056/NEJMoa1908077. Epub 2019 Sep 1.
• Bhatt DL, Steg PG, Mehta SR, Leiter LA, Simon T, Fox K, Held C, Andersson M, Himmelmann A, Ridderstrale W, Chen J, Song Y, Diaz R, Goto S, James SK, Ray KK, Parkhomenko AN, Kosiborod MN, McGuire DK, Harrington RA; THEMIS Steering Committee and Investigators. Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): a phase 3, placebo-controlled, randomised trial. Lancet. 2019 Sep 28;394(10204):1169-1180. doi: 10.1016/S0140-6736(19)31887-2. Epub 2019 Sep 1.
• Bhatt DL, Fox K, Harrington RA, Leiter LA, Mehta SR, Simon T, Andersson M, Himmelmann A, Ridderstrale W, Held C, Steg PG; THEMIS Steering Committee. Rationale, design and baseline characteristics of the effect of ticagrelor on health outcomes in diabetes mellitus patients Intervention study. Clin Cardiol. 2019 May;42(5):498-505. doi: 10.1002/clc.23164. Epub 2019 Apr 9.
• Abtan J, Bhatt DL, Elbez Y, Ducrocq G, Goto S, Smith SC Jr, Ohman EM, Eagle KA, Fox K, Harrington RA, Leiter LA, Mehta SR, Simon T, Petrov I, Sinnaeve PR, Pais P, Lev E, Bueno H, Wilson P, Steg PG; REACH Registry Investigators. External applicability of the Effect of ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) trial: An analysis of patients with diabetes and coronary artery disease in the REduction of Atherothrombosis for Continued Health (REACH) registry. Int J Cardiol. 2023 Jan 1;370:51-57. doi: 10.1016/j.ijcard.2022.10.132. Epub 2022 Oct 19.
• Wittbrodt E, Bhalla N, Sundell KA, Hunt P, Wong ND, Kuster M, Mellstrom C. Assessment of The High risk and unmEt Need in patients with CAD and type 2 diabetes (ATHENA): US healthcare resource use, cost, and burden of illness in a commercially insured population. J Diabetes Complications. 2021 Apr;35(4):107859. doi: 10.1016/j.jdiacomp.2021.107859. Epub 2021 Jan 20.
• Held P, Himmelmann A, Ditmarsch M. Ticagrelor for the treatment of atherosclerotic disease: insights from the PARTHENON clinical development program. Future Cardiol. 2016 Jul;12(4):405-18. doi: 10.2217/fca-2016-0028. Epub 2016 May 10.

Helpful Links

• D513BC00001_CSP_redacted
• D513BC00001_SAP_redacted

Study record dates

Study Major Dates

• Study Start (ACTUAL): February 10, 2014
• Primary Completion (ACTUAL): January 25, 2019
• Study Completion (ACTUAL): January 25, 2019

Study Registration Dates

• First Submitted: November 18, 2013
• First Submitted That Met QC Criteria: November 18, 2013
• First Posted (ESTIMATE): November 25, 2013

Study Record Updates

• Last Update Posted (ACTUAL): March 18, 2020
• Last Update Submitted That Met QC Criteria: March 4, 2020
• Last Verified: March 1, 2020

More Information

Terms related to this study

• Keywords: Diabetes; Coronary artery disease; Prevention; Outcome; Antiplatelet
• Additional Relevant MeSH Terms: Glucose Metabolism Disorders; Metabolic Diseases; Endocrine System Diseases; Diabetes Mellitus; Diabetes Mellitus, Type 2; Physiological Effects of Drugs; Neurotransmitter Agents; Molecular Mechanisms of Pharmacological Action; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Purinergic P2 Receptor Antagonists; Purinergic Antagonists; Purinergic Agents; Ticagrelor
• Other Study ID Numbers: D513BC00001