C1q/TNF-related Proteins in Non-Alcoholic Fatty Liver Disease

September 19, 2016 updated by: Kyung Mook Choi, Korea University

Non-alcoholic fatty liver disease (NAFLD) is characterized by an accumulation of fat in the liver, which is one of the most common forms of chronic liver disease in developed countries. In western countries, the prevalence of NAFLD in the general population is estimated to be 20-30%; in obese populations, this increases to 57.5-74%. But, it hasn't been clearly elucidated yet regarding the underlying disease pathophysiology and treatmet strategy.

Recently, members of the C1q/tumor necrosis factor-related protein (CTRP) family have been reported to share structural homology with adiponectin. To date, 15 CTRP family members have been found that might play major roles in glucose metabolism and inflammation.

The investigators tried to clarify the relationship between CTRP family and NAFLD in Korean men and women.

Study Overview

Status

Unknown

Conditions

NAFLD

Study Type

Observational

Enrollment (Anticipated)

500

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Korea, Republic of
- - Seoul, Korea, Republic of
    - Recruiting
    - Korea Univ. Guro hospital
    - Contact:
      
      Ho Cheol Hong, M.D.
      
      Phone Number: 822-2626-3044
      
      Email: naeyo21@naver.com
    - Contact:
      
      Kyung Mook Choi, M.D.
      
      Phone Number: 822-2626-3043
      
      Email: medica7@gmail.com

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

20 years to 80 years (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

The subjects who visited for a routine health check-up at the Health Promotion Center of Korea University Guro Hospital were enrolled using predefined inclusion and exclusion criteria.

Description

Inclusion Criteria:

20<age<80
apparently healthy subjects

Exclusion Criteria:

a history of CVD
diabetes
stage 2 hypertension
malignancy
severe renal or hepatic disease

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Number of groups / cohorts

Cohorts and Interventions

Group / Cohort
Patients with NAFLD

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
serum concentration of CTRP-1, 3, or 9 in the subjects with/without NAFLD Time Frame: at enrollment	at enrollment

Secondary Outcome Measures

Outcome Measure	Time Frame
The relationships of serum CTRPs/adiponectin levels with cardiometabolic risk profiles Time Frame: at enrollment	at enrollment

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Korea University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

March 1, 2012

Primary Completion (Anticipated)

December 1, 2016

Study Registration Dates

First Submitted

March 7, 2014

First Submitted That Met QC Criteria