- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02821325
Intra-articular Volumetric Assessment After Total Knee Arthroplasty (TKA)
The purpose of the study: is to quantify the amount of post-operative effusion or hematoma present after total knee arthroplasty pre-operatively, post-operative day #0,1.
Patients undergoing a total knee arthroplasty will undergo an MRI on the operative knee at the following times:
- Pre-operatively
- Post-operative day #1 (approximately 16-20 hours post op)
- Post-operative day #2 (approximately 36-40 hours post op) This will be conducted by the Loma Linda radiology department as per normal protocols. No special imaging procedures will be undertaken.
Subjects will be both male and females, they will be patients from the Principle Investigator and Co-Investigators practice. Subjects will be between the ages of 18-89 years of age.
The total participation will last approximately 30 days.
Subject selection will be approximately 10 English speaking, both male and female between the ages of 18 to 89 years of age. Subjects will be recruited from the Principal Investigators and Co-Investigators clinic. There will be no advertising or electronic recruiting. The study is expected to last 12 months.
Study Overview
Detailed Description
STUDY DESIGN:
Background or rationale for this study:
Total knee arthroplasty is one of the most successful orthopedic surgeries performed in the United States, and consistently has shown to have excellent outcomes for patients, with low complication rates. However, when complications do happen, they can range from superficial infection to repeated deep infection requiring prosthesis exchange or amputation. Another significant complication of total knee arthroplasty is joint stiffness. Range of motion loss can also be an extremely debilitating complication necessitating prolonged physical therapy, return to the operating theater for manipulation or even total synovectomy and polyethylene exchange.
Although it is currently known that post-operative hematoma leads to adverse outcomes following total knee arthroplasty, there is currently no literature to quantify the average size or progression of the intra-articular bleeding post operatively. It would be reasonable to assume that all patients develop a slight hematoma post operatively. The investigator aims to assess the size, and possible progression of the intra-articular hematoma following total knee arthroplasty.
OBJECTIVES:
The investigator aims to:
Quantify the amount of post-operative effusion or hematoma present after total knee arthroplasty pre-operatively, post-operative day #0, 1.
Procedures involved (Research Interventions)
Patients undergoing a total knee arthroplasty will undergo an MRI of the operative knee at the following times:
- Pre-operatively
- Post-operative day #1 (approximately 16-20 hours post op)
- Post-operative day #2 (approximately 36-40 hours post op)
This will be conducted by the Loma Linda radiology department as per normal protocols. No special imaging procedures will be undertaken.
No changes in operative technique or post-operative protocol will be undertaken due to study apart from the above imaging.
All imaging will be kept on the LLUMC PACS system. Concise review of literature that supports the rationale, objectives, and methodology of the proposed study.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
-
California
-
Loma Linda, California, United States, 92354
- Loma Linda University Healthcare Department of Orthopaedic Surgery
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Patients undergoing elective primary total knee arthroplasty.
- Patients not meeting exclusion criteria
Exclusion Criteria:
- If patient is not able to undergo MRI
- Heart pacemaker
- Cochlear implant
- Metallic foreign body (metal silver) in the eyes
- Aneurysm clip in the brain
- Patient with prior reaction or contra-indication to tranexamic acid
- Inability to comprehend consent process
- Age <18 or > 89
- Patient planned for outpatient procedure
- Active malignancy
- Patients with hematologic disorders (hemophilia, factor V Leiden, etc.)
- Patients with any condition that makes undergoing a MRI painful (severe spine degenerative disease, vertigo, etc.)
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
MRI
Radiology
|
Patients undergoing a total knee arthroplasty, will undergo additional MRI's. One MRI pre-operatively. 2nd MRI post-operatively on day 1. 3rd MRI post-operatively on day 2. |
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Participants with total knee arthroplasty assessed for intra-articular hematoma
Time Frame: 30 days
|
MRI studies will be reviewed on these participants pre-operatively and postoperatively.
Data will be analyzed using the Statistical package for social sciences (SPSS) software and paired T-Test will be utilized for significance regarding the effusion post operatively.
|
30 days
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Nirav H. Amin, MD, Loma Linda University Faculty
Study record dates
Study Major Dates
Study Start (ACTUAL)
Primary Completion (ACTUAL)
Study Completion (ACTUAL)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ESTIMATE)
Study Record Updates
Last Update Posted (ACTUAL)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 5160043
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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