A Randomized, Double-blind, Placebo-controlled Study to Assess the Effects of Bempedoic Acid (ETC-1002) on the Occurrence of Major Cardiovascular Events in Patients With, or at High Risk for, Cardiovascular Disease Who Are Statin Intolerant

Evaluation of Major Cardiovascular Events in Patients With, or at High Risk for, Cardiovascular Disease Who Are Statin Intolerant Treated With Bempedoic Acid (ETC-1002) or Placebo

Sponsors

Lead sponsor: Esperion Therapeutics

Collaborator: The Cleveland Clinic

Source Esperion Therapeutics
Brief Summary

The purpose of this study is to determine if treatment with bempedoic acid (ETC-1002) versus placebo decreases the risk of cardiovascular events in patients who are statin intolerant.

Overall Status Active, not recruiting
Start Date November 18, 2016
Completion Date December 2022
Primary Completion Date August 2022
Phase Phase 3
Study Type Interventional
Primary Outcome
Measure Time Frame
Time from randomization to first occurrence of one of the following adjudicated composite endpoints: CV death, nonfatal myocardial infarction (MI), nonfatal stroke, or coronary revascularization. 3.75 years (estimated average treatment duration)
Enrollment 14014
Condition
Intervention

Intervention type: Drug

Intervention name: Bempedoic acid 180 mg tablet

Description: Patients take bempedoic acid 180 mg tablet orally once daily

Arm group label: Bempedoic Acid 180 mg

Other name: ETC-1002

Intervention type: Drug

Intervention name: Matching placebo tablet

Description: Patients take matching placebo tablet orally once daily

Arm group label: Placebo Comparator

Other name: placebo comparator

Eligibility

Criteria:

Inclusion Criteria:

- Age between 18 and 85 years

- History of, or at high risk for, cardiovascular disease (CVD) including coronary artery disease, symptomatic peripheral arterial disease, cerebrovascular atherosclerotic disease, or at high risk for a cardiovascular event

- Patient reported history of statin intolerance (inability to tolerate 2 or more statins, one at a low dose)

- Men and nonpregnant, nonlactating women

- Fasting blood LDL-cholesterol ≥ 100 (2.6 mmol/L) at screening

Exclusion Criteria:

- Fasting blood triglycerides greater than 500 mg/dL (5.6 mmol/L) at screening

- Recent (within 90 days of screening) history of major cardiovascular events, transient ischemic attack (TIA), or unstable or symptomatic cardiac arrhythmia

- History of severe heart failure

- Uncontrolled hypertension or uncontrolled diabetes

Gender: All

Minimum age: 18 Years

Maximum age: 85 Years

Healthy volunteers: No

Overall Official
Last Name Role Affiliation
Ron Haberman, MD Study Director Esperion Therapeutics
Location
facility
| Birmingham, Alabama, 35211, United States
| Birmingham, Alabama, 35235, United States
| Huntsville, Alabama, 35802, United States
| Mobile, Alabama, 36608, United States
| Mobile, Alabama, 36617, United States
| Pell City, Alabama, 35125, United States
| Tuscumbia, Alabama, 35674, United States
| Chandler, Arizona, 85224, United States
| Cottonwood, Arizona, 86326, United States
| Fountain Hills, Arizona, 85268, United States
| Gilbert, Arizona, 85295, United States
| Glendale, Arizona, 85306, United States
| Glendale, Arizona, 85308, United States
| Mesa, Arizona, 85206, United States
| Phoenix, Arizona, 85020, United States
| Phoenix, Arizona, 85050, United States
| Tucson, Arizona, 85712, United States
| Tucson, Arizona, 85741, United States
| Beverly Hills, California, 90211, United States
| Carlsbad, California, 92008, United States
| Huntington Beach, California, 92648-1717, United States
| Lincoln, California, 95648, United States
| Long Beach, California, 90806, United States
| Long Beach, California, 90807, United States
| Northridge, California, 91324, United States
| Oceanside, California, 92056, United States
| Rancho Cucamonga, California, 91730, United States
| San Diego, California, 92108, United States
| Santa Ana, California, 92705, United States
| Santa Rosa, California, 95405, United States
| Torrance, California, 90509, United States
| Vista, California, 92083, United States
| Aurora, Colorado, 80012, United States
| Colorado Springs, Colorado, 80909, United States
| Colorado Springs, Colorado, 80922, United States
| Golden, Colorado, 80401, United States
| Littleton, Colorado, 80120, United States
| Loveland, Colorado, 80538, United States
| Hamden, Connecticut, 06517, United States
| Hartford, Connecticut, 06102, United States
| North Haven, Connecticut, 06473, United States
| Stamford, Connecticut, 06905, United States
| Boca Raton, Florida, 33434, United States
| Boynton Beach, Florida, 33435, United States
| Boynton Beach, Florida, 33472, United States
| Bradenton, Florida, 34209, United States
| Clearwater, Florida, 33756, United States
| Crystal River, Florida, 34429, United States
| Fleming Island, Florida, 32003, United States
| Fort Lauderdale, Florida, 33008, United States
| Fort Lauderdale, Florida, 33308, United States
| Green Acres, Florida, 33467, United States
| Hialeah, Florida, 33010, United States
| Hialeah, Florida, 33012, United States
| Inverness, Florida, 34452, United States
| Jacksonville, Florida, 32205, United States
| Jacksonville, Florida, 32216, United States
| Jacksonville, Florida, 32277, United States
Center for Advanced Research Excellence LLC, Hialeah | Jupiter, Florida, 33458, United States
| Jupiter, Florida, 33458, United States
| Lake Worth, Florida, 33461, United States
| Largo, Florida, 33770, United States
| Largo, Florida, 33777, United States
| Melbourne, Florida, 32934, United States
| Miami Lakes, Florida, 33016, United States
| Miami, Florida, 33125, United States
Pharmax Research Clinic | Miami, Florida, 33126, United States
| Miami, Florida, 33133, United States
Elite Clinical Research | Miami, Florida, 33144, United States
| Miami, Florida, 33144, United States
Future Care Solution, LLC | Miami, Florida, 33165, United States
Med-Care Research | Miami, Florida, 33165, United States
| Miami, Florida, 33165, United States
| Miami, Florida, 33172, United States
South Florida Research Group, LLC | Miami, Florida, 33173, United States
| Miami, Florida, 33173, United States
| Miami, Florida, 33175, United States
| Miami, Florida, 33186, United States
| Naples, Florida, 34102, United States
| New Port Richey, Florida, 34655, United States
| North Miami Beach, Florida, 33162, United States
| Ocala, Florida, 34471, United States
| Orlando, Florida, 32825, United States
| Ormond Beach, Florida, 32174, United States
| Pembroke Pines, Florida, 33025, United States
Family Clinical Trials, LLC. | Pembroke Pines, Florida, 33026, United States
| Pembroke Pines, Florida, 33026, United States
| Pembroke Pines, Florida, 33027, United States
| Pinellas Park, Florida, 33781, United States
| Ponte Vedra, Florida, 32081, United States
| Port Charlotte, Florida, 33952, United States
| Safety Harbor, Florida, 34695, United States
| Saint Petersburg, Florida, 33713, United States
| Tampa, Florida, 33624, United States
| Wellington, Florida, 33449, United States
| Atlanta, Georgia, 30322, United States
| Columbus, Georgia, 31904, United States
| Covington, Georgia, 30014, United States
| Cumming, Georgia, 30041, United States
| Dunwoody, Georgia, 30338, United States
| Gainesville, Georgia, 30501, United States
| Macon, Georgia, 31201, United States
| Savannah, Georgia, 31406, United States
| Tucker, Georgia, 30084, United States
| Woodstock, Georgia, 30189, United States
| Meridian, Idaho, 83646, United States
| Champaign, Illinois, 61820, United States
| Chicago, Illinois, 60602, United States
| Gurnee, Illinois, 60031, United States
| Jerseyville, Illinois, 62052, United States
| Olympia Fields, Illinois, 60461, United States
| Rock Island, Illinois, 61201, United States
| Rockford, Illinois, 61107, United States
| Anderson, Indiana, 46011, United States
| Elkhart, Indiana, 46514-2487, United States
| Evansville, Indiana, 47714, United States
| Evansville, Indiana, 47715, United States
| Indianapolis, Indiana, 46237, United States
| Indianapolis, Indiana, 46290, United States
| Munster, Indiana, 46321, United States
| Richmond, Indiana, 47374, United States
| Council Bluffs, Iowa, 51501, United States
Lipid Research Clinic - University of Iowa | Iowa City, Iowa, 52242, United States
| Iowa City, Iowa, 52242, United States
| Waterloo, Iowa, 50702, United States
| West Des Moines, Iowa, 50266, United States
| Hutchinson, Kansas, 67502, United States
| Kansas City, Kansas, 66160, United States
| Wichita, Kansas, 67205-1138, United States
| Elizabethtown, Kentucky, 42701, United States
| Lexington, Kentucky, 40503, United States
L-MARC Research Center | Louisville, Kentucky, 40213, United States
| Louisville, Kentucky, 40213, United States
| Paducah, Kentucky, 42003, United States
| Eunice, Louisiana, 70535, United States
| Lake Charles, Louisiana, 70601, United States
| New Orleans, Louisiana, 70121, United States
| New Orleans, Louisiana, 70124, United States
| West Monroe, Louisiana, 71291, United States
| Annapolis, Maryland, 21401, United States
| Baltimore, Maryland, 21218, United States
| Baltimore, Maryland, 21228, United States
| Baltimore, Maryland, 21229, United States
Medstar Cardiology Group at Franklin Square | Baltimore, Maryland, 21237, United States
| Columbia, Maryland, 21044, United States
Optimal Research, LLC | Rockville, Maryland, 20850, United States
| Salisbury, Maryland, 21804, United States
CPG Baltimore Research | Towson, Maryland, 21204, United States
| Haverhill, Massachusetts, 01830, United States
| Hyannis, Massachusetts, 02601, United States
| Buckley, Michigan, 49620, United States
| Cadillac, Michigan, 49601, United States
| Caro, Michigan, 48723, United States
| Grand Blanc, Michigan, 48439, United States
| Grand Rapids, Michigan, 49546, United States
| Kalamazoo, Michigan, 49009, United States
| Lansing, Michigan, 48910, United States
| Lansing, Michigan, 48912, United States
| Mount Clemens, Michigan, 48043, United States
| Petoskey, Michigan, 49770, United States
| Saginaw, Michigan, 48601, United States
| Sterling Heights, Michigan, 48312, United States
| Troy, Michigan, 48085, United States
| Minneapolis, Minnesota, 55455, United States
| Richfield, Minnesota, 55432, United States
| Saint Cloud, Minnesota, 56303-1900, United States
| Saint Paul, Minnesota, 55101, United States
| Saint Paul, Minnesota, 55102, United States
| Tupelo, Mississippi, 38801, United States
| Bridgeton, Missouri, 63044, United States
| Saint Louis, Missouri, 63128, United States
| Saint Louis, Missouri, 63141, United States
| Kalispell, Montana, 59901, United States
| Fremont, Nebraska, 68025, United States
| Lincoln, Nebraska, 68526, United States
| Omaha, Nebraska, 68144, United States
| Henderson, Nevada, 89052, United States
| Las Vegas, Nevada, 89119, United States
Foundation Cardiology | Nashua, New Hampshire, 03060, United States
| Nashua, New Hampshire, 03060, United States
| Bridgeton, New Jersey, 08302, United States
| Bridgewater, New Jersey, 08807, United States
| Flemington, New Jersey, 08822, United States
| Haddon, New Jersey, 08035, United States
| Linden, New Jersey, 07036, United States
| Sewell, New Jersey, 08080, United States
| Teaneck, New Jersey, 07666, United States
| Albany, New York, 12211, United States
| Binghamton, New York, 13901, United States
| Bronxville, New York, 10708, United States
Buffalo Heart Group | Buffalo, New York, 14215, United States
| Endwell, New York, 13760, United States
| Jackson Heights, New York, 11372, United States
| Jamaica, New York, 11432, United States
| Manhasset, New York, 11030, United States
| New Windsor, New York, 12553, United States
| New York, New York, 10029, United States
| New York, New York, 10036, United States
| Poughkeepsie, New York, 12601, United States
| Saratoga Springs, New York, 12866, United States
| Southampton, New York, 11968, United States
| Asheboro, North Carolina, 27203, United States
| Burlington, North Carolina, 27215, United States
| Cary, North Carolina, 27511, United States
PMG Research of Cary | Cary, North Carolina, 27518, United States
| Cary, North Carolina, 27518, United States
| Charlotte, North Carolina, 28204, United States
| Greensboro, North Carolina, 27401, United States
Medication Management, LLC | Greensboro, North Carolina, 27408, United States
| Greensboro, North Carolina, 27408, United States
| Greensboro, North Carolina, 27410, United States
PMG Research of Hickory | Hickory, North Carolina, 28601, United States
| Hickory, North Carolina, 28601, United States
| Lenoir, North Carolina, 28645, United States
| Mooresville, North Carolina, 28117, United States
| Morehead City, North Carolina, 28557, United States
PMG Research of Raleigh, LLC | Raleigh, North Carolina, 27609, United States
PMG Research of Raleigh | Raleigh, North Carolina, 27609, United States
| Raleigh, North Carolina, 27609, United States
PMG Research of Rocky Mount | Rocky Mount, North Carolina, 27804, United States
| Rocky Mount, North Carolina, 28404, United States
| Sanford, North Carolina, 27330, United States
| Wilmington, North Carolina, 28401, United States
| Winston-Salem, North Carolina, 27157, United States
| Fargo, North Dakota, 58103, United States
| Akron, Ohio, 44304, United States
| Akron, Ohio, 44311, United States
| Canton, Ohio, 44710, United States
| Cincinnati, Ohio, 45236, United States
| Cleveland, Ohio, 44109, United States
| Cleveland, Ohio, 44195, United States
| Columbus, Ohio, 43210, United States
Synexus Clinical Research | Columbus, Ohio, 43212, United States
| Dayton, Ohio, 45419, United States
| Franklin, Ohio, 45005, United States
| Marion, Ohio, 43302, United States
| Maumee, Ohio, 43537, United States
| Middleburg Heights, Ohio, 44130, United States
| Norman, Oklahoma, 73069, United States
| Oklahoma City, Oklahoma, 73111, United States
| Oklahoma City, Oklahoma, 73120, United States
| Oklahoma City, Oklahoma, 73134, United States
| Oklahoma City, Oklahoma, 73135, United States
| Tulsa, Oklahoma, 74133, United States
Abington Medical Specialists | Abington, Pennsylvania, 19001, United States
| Beaver, Pennsylvania, 15009, United States
| Camp Hill, Pennsylvania, 17011, United States
| Johnstown, Pennsylvania, 15905, United States
| McMurray, Pennsylvania, 15317, United States
| Natrona Heights, Pennsylvania, 15065, United States
| Pittsburgh, Pennsylvania, 15236, United States
| Smithfield, Pennsylvania, 15478, United States
| Uniontown, Pennsylvania, 15401, United States
| York, Pennsylvania, 17403, United States
| Cumberland, Rhode Island, 02864, United States
| Providence, Rhode Island, 02906, United States
| Anderson, South Carolina, 29621-2062, United States
| Anderson, South Carolina, 29621, United States
| Charleston, South Carolina, 29407, United States
| Charleston, South Carolina, 29425, United States
| Greer, South Carolina, 29651, United States
| Indian Land, South Carolina, 29707, United States
| Little River, South Carolina, 29566, United States
| Summerville, South Carolina, 29485, United States
| Rapid City, South Dakota, 57701, United States
| Rapid City, South Dakota, 57702, United States
| Fayetteville, Tennessee, 37334, United States
| Greeneville, Tennessee, 37745, United States
| Jackson, Tennessee, 38301, United States
| Knoxville, Tennessee, 37918, United States
| Allen, Texas, 75013, United States
Pharma Tex Research, LLP | Amarillo, Texas, 79106, United States
| Amarillo, Texas, 79106, United States
Seton Heart Institute | Austin, Texas, 78705, United States
| Dallas, Texas, 75226, United States
| Dallas, Texas, 75231, United States
| Dallas, Texas, 75234, United States
| Dallas, Texas, 75235, United States
| DeSoto, Texas, 75115, United States
| Fort Worth, Texas, 76107, United States
| Fort Worth, Texas, 76132, United States
| Houston, Texas, 77008, United States
| Houston, Texas, 77030, United States
| Houston, Texas, 77054, United States
| Houston, Texas, 77074, United States
| Katy, Texas, 77450, United States
| Kerrville, Texas, 78028, United States
| Lubbock, Texas, 79410, United States
| McKinney, Texas, 75017, United States
| Odessa, Texas, 79761, United States
| Pearland, Texas, 77584, United States
| Plano, Texas, 75024, United States
| Plano, Texas, 75093, United States
| San Angelo, Texas, 76904, United States
| San Antonio, Texas, 78229, United States
| San Antonio, Texas, 78230, United States
| Schertz, Texas, 78154, United States
| Sugar Land, Texas, 77479, United States
| Tomball, Texas, 77375, United States
| Tyler, Texas, 75701, United States
| Victoria, Texas, 77901, United States
| Farmington, Utah, 84025, United States
| Layton, Utah, 84041, United States
| Murray, Utah, 84123, United States
| Orem, Utah, 84058, United States
| Burke, Virginia, 22015, United States
| Charlottesville, Virginia, 22903, United States
| Danville, Virginia, 24541, United States
| Falls Church, Virginia, 22042, United States
| Hampton, Virginia, 23666, United States
York Clinical Research, LLC | Norfolk, Virginia, 23510, United States
| Roanoke, Virginia, 24014, United States
Hampton Roads Center for Clinical Research | Suffolk, Virginia, 23435, United States
| Suffolk, Virginia, 23435, United States
| Woodbridge, Virginia, 22192, United States
| Bellevue, Washington, 98004, United States
| Green Bay, Wisconsin, 54301, United States
| Kenosha, Wisconsin, 53144, United States
| La Crosse, Wisconsin, 54601, United States
| Madison, Wisconsin, 53713, United States
| Bahia Blanca, Buenos Aires, B8000FTD, Argentina
| Bahía Blanca, Buenos Aires, 8000, Argentina
| Bahía Blanca, Buenos Aires, B8001HXM, Argentina
| Berazategui, Buenos Aires, 1884, Argentina
| Ciudad Autónoma de Buenos Aires, Buenos Aires, 1426, Argentina
| Ciudad Autónoma de Buenos Aires, Buenos Aires, C1179AAB, Argentina
| Coronel Suárez, Buenos Aires, B7540GHD, Argentina
| Haedo, Buenos Aires, B1706CZA, Argentina
| La Plata, Buenos Aires, B1900AXI, Argentina
| Mar Del Plata, Buenos Aires, B7600FYK, Argentina
| Mar Del Plata, Buenos Aires, B7600FZ, Argentina
| Mar del Plata, Buenos Aires, B7600GNY, Argentina
| Mar Del Plata, Buenos Aires, B7602CBM, Argentina
| Moron, Buenos Aires, 1708, Argentina
| San Martín, Buenos Aires, B1650CSQ, Argentina
| Vicente López, Buenos Aires, 1602, Argentina
| Zárate, Buenos Aires, B2800DGH, Argentina
| Villa Luro, Ciudad Autonoma Buenos Aires, C1440CFD, Argentina
| Caba, Ciudad Autonoma, C1419GEP, Argentina
| Ciudad Autónoma de Buenos Aire, Ciudad Autonoma, C1093AAS, Argentina
| Ciudad Autónoma de Buenos Aire, Ciudad Autonoma, C1119ACN, Argentina
| Ciudad Autónoma de Buenos Aire, Ciudad Autonoma, C1425DES, Argentina
| Ciudad Autónoma de Buenos Aire, Ciudad Autonoma, C1428ART, Argentina
| Ciudad Autónoma de Buenos Aire, Ciudad Autonoma, C1430CKE, Argentina
| Córdoba, Cordoba, 5000, Argentina
| Córdoba, Cordoba, X50000EVQ, Argentina
| Córdoba, Cordoba, X5003DCP, Argentina
| San Vicente, Cordoba, X5006CBI, Argentina
| Godoy Cruz, Mendoza, 5501, Argentina
| San Rafael, Mendoza, CP5600, Argentina
| Temperley, Partido De Lomas De Zamora, 1834, Argentina
| San Fernando, Provincia De Buenos AIres, B1646EBJ, Argentina
| Rosario, Santa Fe, 2000, Argentina
| Rosario, Santa Fe, CP2000, Argentina
| Rosario, Santa Fe, S2000DIF, Argentina
| Rosario, Santa Fe, S2000DNM, Argentina
| Rosario, Sante Fe, 2000, Argentina
| San Miguel De Tucumán, Tucuman, T4000, Argentina
| San Miguel de Tucumán, Tucumán, T4000ICL, Argentina
| Buenos Aires, C1180AAX, Argentina
| Buenos Aires, C1425AGC, Argentina
| Ciudad Autonoma Buenos Aires, C1118AAE, Argentina
| Ciudad Autonoma Buenos Aires, C1128AAE, Argentina
| Ciudad Autonoma de Buenos Aires, 1056, Argentina
| Ciudad Autonoma de Buenos Aires, 1406, Argentina
| Ciudad Autonoma de Buenos Aires, C1280AEB, Argentina
| Ciudad Autonoma de Buenos Aires, C1405BCK, Argentina
| Ciudad Autónoma de Buenos Aires, C1179AAB, Argentina
| Cordoba, 5008, Argentina
| Cordoba, X5000AAW, Argentina
| Cordoba, X5000AOQ, Argentina
| Cordoba, X5000BNB, Argentina
| Cordoba, X5000JHQ, Argentina
| Cordoba, X5003DCE, Argentina
| Corrientes, 3400, Argentina
| Córdoba, 5016, Argentina
| La Plata, B1900EHD, Argentina
| La Plata, B1902COS, Argentina
| Lanús, B1824KAJ, Argentina
| Morón, B1708GIK, Argentina
| Pilar, B1629ODT, Argentina
| Quilmes, B1878GEG, Argentina
| Ramos Mejía, B1704ETD, Argentina
| Rosario, S2000ORE, Argentina
| Rosario, S2001ODA, Argentina
| Salta, 4406, Argentina
| San Lorenzo, 2200, Argentina
| San Miguel de Tucuman, T4000IFL, Argentina
| Santa Fe, S3000EOZ, Argentina
| Santa Fe, S3000FWO, Argentina
| Tucuman, T4000ICL, Argentina
| Adamstown, New South Wales, 2289, Australia
| Camperdown, New South Wales, 2050, Australia
| Gosford, New South Wales, 2250, Australia
| Liverpool, New South Wales, 2170, Australia
| Merewether, New South Wales, 2291, Australia
| Tumbi Umbi, New South Wales, 2261, Australia
| Wollongong, New South Wales, 2522, Australia
| Auchenflower, Queensland, 4066, Australia
| Bundaberg, Queensland, 4670, Australia
| Chermside, Queensland, 4032, Australia
| Milton, Queensland, 4064, Australia
| Sherwood, Queensland, 4075, Australia
| Sippy Downs, Queensland, 4556, Australia
| Woolloongabba, Queensland, 4102, Australia
Royal Adelaide Hospital | Adelaide, South Australia, 5000, Australia
| Adelaide, South Australia, 5000, Australia
| Ashford, South Australia, 5035, Australia
| Fullarton, South Australia, 5063, Australia
| Hobart, Tasmania, 7000, Australia
| Ballarat, Victoria, 3350, Australia
| Box Hill, Victoria, 3128, Australia
| Clayton, Victoria, 3168, Australia
| Fitzroy, Victoria, 3065, Australia
| Frankston, Victoria, 3199, Australia
| Langwarrin, Victoria, 3910, Australia
| Melbourne, Victoria, 3004, Australia
| Mildura, Victoria, 3500, Australia
| Joondalup, Western Australia, 6027, Australia
| Murdoch, Western Australia, 6150, Australia
| Nedlands, Western Australia, 6009, Australia
Royal Perth Hospital | Perth, Western Australia, 6000, Australia
| Perth, Western Australia, 6000, Australia
| Subiaco, Western Australia, 6008, Australia
| Feldkirch, 6807, Austria
| Graz, 8036, Austria
| Innsbruck, 6020, Austria
| Linz, 4020, Austria
| Linz, 4021, Austria
| Vienna, 1090, Austria
| Wiener Neustadt, 2700, Austria
| Wien, 1030, Austria
| Wien, 1060, Austria
| Wien, 1130, Austria
| Wien, 1170, Austria
| Aalst, 9300, Belgium
| Antwerpen, 2020, Belgium
| Antwerpen, 2060, Belgium
| Brasschaat, 2930, Belgium
| Brugge, 8000, Belgium
| Bruxelles, 1070, Belgium
| Bruxelles, 1090, Belgium
| De Pinte, 9840, Belgium
| Dendermonde, 9200, Belgium
| Edegem, 2650, Belgium
| Genk, 3600, Belgium
| Gent, 9000, Belgium
| Halen, 3545, Belgium
| Liège, 4000, Belgium
| Mechelen, 2800, Belgium
| Merksem, 2170, Belgium
| Mons, 7000, Belgium
| Tienen, 3300, Belgium
| Turnhout, 2300, Belgium
| Wetteren, 9230, Belgium
| Yvoir, 5530, Belgium
| Salvador, Bahia, 41950-275, Brazil
| Fortaleza, Ceará, 60160-230, Brazil
| Fortaleza, Ceará, 60430-350, Brazil
ICE-HUWC - Instituto Cearense de Endocrinologia do Hospital Universitário Walter Cantídio | Fortaleza, Ceará, 60430-370, Brazil
| Fortaleza, Ceará, 60430-370, Brazil
| Fortaleza, Ceará, 60846-190, Brazil
| Brasília, Distrito Federal, 70200-730, Brazil
| Brasília, Distrito Federal, 70710-100, Brazil
| Brasília, Distrito Federal, 71655-175, Brazil
| Vitória, Espírito Santo, 29055-450, Brazil
| Goiânia, Goiás, 74210-050, Brazil
| Goiânia, Goiás, 74223-130, Brazil
| Campo Grande, Mato Grosso Do Sul, 79080-190, Brazil
| Belo Horizonte, Minas Gerais, 30110-934, Brazil
| Belo Horizonte, Minas Gerais, 30140-062, Brazil
| Belo Horizonte, Minas Gerais, 30150-240, Brazil
| Uberlândia, Minas Gerais, 38411-186, Brazil
| Curitiba, Paraná, 80030-110, Brazil
| Curitiba, Paraná, 80030-480, Brazil
| Curitiba, Paraná, 80060-900, Brazil
| Curitiba, Paraná, 80730-150, Brazil
| Belém, Pará, 66073-000, Brazil
| Recife, Pernambuco, 52051-380, Brazil
| Boa Vista, Recife, 50070, Brazil
| Natal, Rio Grande Do Norte, 59020-500, Brazil
| Passo Fundo, Rio Grande Do Sul, 99010-080, Brazil
| Porto Alegre, Rio Grande Do Sul, 90035-170, Brazil
| Porto Alegre, Rio Grande Do Sul, 90510-040, Brazil
| Porto Alegre, Rio Grande Do Sul, 90620-001, Brazil
| Porto Alegre, Rio Grande Do Sul, 90840-440, Brazil
| Santa Maria, Rio Grande Do Sul, 97015-530, Brazil
| Caxias Do Sul, Rio Grande Du Sul, 95070-560, Brazil
| Porto Alegre, Rio Grande Du Sul, 90020-090, Brazil
| Balneário Camboriú, Santa Catarina, 88331-085, Brazil
| Blumenau, Santa Catarina, 89010-906, Brazil
| Campinas, Sao Paulo, 13010-001, Brazil
| Campinas, Sao Paulo, 13020-431, Brazil
| Campinas, Sao Paulo, 13060-080, Brazil
| Cotia, Sao Paulo, 06717-100, Brazil
| Jaú, Sao Paulo, 17210-190, Brazil
| Marília, Sao Paulo, 17515-000, Brazil
| Santo André, Sao Paulo, 09030-010, Brazil
| Santo André, Sao Paulo, 09080-110, Brazil
| Santo André, Sao Paulo, 09090-790, Brazil
| São José Do Rio Preto, Sao Paulo, 15090-000, Brazil
| São José dos Campos, Sao Paulo, 12243-280, Brazil
| São Paulo, Sao Paulo, 01141-020, Brazil
| São Paulo, Sao Paulo, 01221-020, Brazil
| São Paulo, Sao Paulo, 01228-000, Brazil
| São Paulo, Sao Paulo, 01244-030, Brazil
| São Paulo, Sao Paulo, 01327-010, Brazil
| São Paulo, Sao Paulo, 01406-200, Brazil
| São Paulo, Sao Paulo, 01506-000, Brazil
| São Paulo, Sao Paulo, 050017-000, Brazil
| Tatuí, Sao Paulo, 18270-170, Brazil
| Votuporanga, Sao Paulo, 15500-003, Brazil
| Sao Paulo, Sau Paulo, 05403-000, Brazil
| Paraíso, São Paulo, 4005, Brazil
| São José Do Rio Preto, São Paulo, 15015, Brazil
| Bela Vista, 1323, Brazil
| Belo Horizonte, 30140, Brazil
| Belo Horizonte, 30190, Brazil
| Belo Horizonte, 31150221, Brazil
| Bento Gonçalves, 95700068, Brazil
| Brasília, 70658, Brazil
| Curitiba, 80045, Brazil
| Curitiba, 80230130, Brazil
| Curitiba, 80730150, Brazil
| Goiânia, 74093, Brazil
| Joinville, 89227, Brazil
| Maceió, 57051, Brazil
| Marilia, 17515, Brazil
| Maringá, 87015001, Brazil
| Porto Alegre, 90035, Brazil
| Porto Alegre, 91350200, Brazil
| Rio de Janeiro, 22271-100, Brazil
| Salvador, 40050, Brazil
| Salvador, 40110, Brazil
| Salvador, 40170, Brazil
| Salvador, 41820, Brazil
| Santa Maria, 97105, Brazil
| São José, 88103, Brazil
| São Luís, 65077357, Brazil
| São Paulo, 08270-070, Brazil
| São Paulo, 0, Brazil
| Blagoevgrad, 2700, Bulgaria
| Byala, 7100, Bulgaria
| Dimitrovgrad, 6400, Bulgaria
| Haskovo, 6300, Bulgaria
MHAT - Pazardzhik AD | Pazardzhik, 4400, Bulgaria
| Pazardzhik, 4400, Bulgaria
| Pernik, 2300, Bulgaria
MHAT "Sv. Pantaleymon - Pleven", OOD | Pleven, 5800, Bulgaria
| Pleven, 5800, Bulgaria
| Plovdiv, 4000, Bulgaria
| Plovdiv, 4002, Bulgaria
| Ruse, 7000, Bulgaria
| Ruse, 7013, Bulgaria
| Sandanski, 2800, Bulgaria
| Sliven, 8800, Bulgaria
| Sofia, 1040, Bulgaria
| Sofia, 1202, Bulgaria
| Sofia, 1233, Bulgaria
| Sofia, 1309, Bulgaria
| Sofia, 1336, Bulgaria
| Sofia, 1407, Bulgaria
| Sofia, 1408, Bulgaria
| Sofia, 1431, Bulgaria
| Sofia, 1527, Bulgaria
| Sofia, 1606, Bulgaria
| Sofia, 1680, Bulgaria
| Sofia, 1750, Bulgaria
| Sofia, 1784, Bulgaria
| Stara Zagora, 6000, Bulgaria
| Stara Zagora, 6004, Bulgaria
| Varna, 9000, Bulgaria
| Varna, 9002, Bulgaria
| Varna, 9020, Bulgaria
| Veliko Tarnovo, 5000, Bulgaria
| Yambol, 8600, Bulgaria
| Victoria, British Columbia, V8T 5G4, Canada
| Mount Pearl, Newfoundland and Labrador, A1N 1W7, Canada
| Brampton, Ontario, L6T 0G1, Canada
| Brampton, Ontario, L6Z 4N5, Canada
| Cambridge, Ontario, N1R 6V6, Canada
| Cambridge, Ontario, N1R 7R1, Canada
| London, Ontario, N5W 6A2, Canada
| Newmarket, Ontario, L3Y 5G8, Canada
| Oakville, Ontario, L6K 3W7, Canada
| Peterborough, Ontario, K9J 0B2, Canada
| Sarnia, Ontario, N7T 4X3, Canada
| Sudbury, Ontario, P3E 5M4, Canada
| Toronto, Ontario, M9V 4B4, Canada
| Chicoutimi, Quebec, G7H 7K9, Canada
| Longueuil, Quebec, J4M 2X1, Canada
| Longueuil, Quebec, J4N 2H4, Canada
| Montréal, Quebec, H1T 1C8, Canada
| Montréal, Quebec, H1T 3Y7, Canada
| Pointe-Claire, Quebec, H9R 3J1, Canada
| Saint-Georges, Quebec, G5Y 4T8, Canada
| St-Jérôme, Quebec, J7Z 5T3, Canada
| St. Jean sur Richelieu, Quebec, J3A 1J2, Canada
| Victoriaville, Quebec, G6P 6P6, Canada
| Quebec, G1V 4G5, Canada
| Québec, G1G 3Y8, Canada
| San Bernardo, 8071064, Chile
| Santiago, 00000, Chile
| Santiago, 7500000, Chile
| Santiago, 7500739, Chile
| Santiago, 8150000, Chile
| Santiago, 8331143, Chile
| Santiago, 8910131, Chile
| Temuco, 4781156, Chile
| Viña del Mar, 2520997, Chile
| Barranquilla, 0000, Colombia
| Barranquilla, 080020, Colombia
Centro de Diabetes Cardiovascular | Barranquilla, 80020, Colombia
| Barranquilla, 80020, Colombia
| Bogota, 110221, Colombia
| Bogota, 111111, Colombia
| Bogotá, 1013, Colombia
| Bogotá, 110911, Colombia
| Bogotá, 111211, Colombia
| Bucaramanga, 00000, Colombia
| Bucaramanga, 681004, Colombia
| Cali, 760035, Colombia
| Cali, 760036, Colombia
| Cartagena, 130010, Colombia
| Cartagena, 13001, Colombia
| Espinal, 00000, Colombia
| Ibagué, 730006, Colombia
| Manizales, 170004, Colombia
| Medellin, 00000, Colombia
| Medellin, 050021, Colombia
| Pereira, 00000, Colombia
| San Gil, 00000, Colombia
| Zipaquirá, 250252, Colombia
| Dubrovnik, 20000, Croatia
| Koprivnica, 48000, Croatia
| Krapinske Toplice, 49217, Croatia
| Opatija, 51410, Croatia
| Osijek, 31000, Croatia
| Rijeka, 51000, Croatia
| Slavonski Brod, 35000, Croatia
| Varazdin, 42000, Croatia
| Virovitica, 33000, Croatia
| Zabok, 49210, Croatia
| Zadar, 23000, Croatia
| Zagreb, 10000, Croatia
| Čakovec, 40000, Croatia
| Benátky Nad Jizerou, 294 71, Czechia
| Beroun, 266 01, Czechia
| Brandýs Nad Labem, 25001, Czechia
| Brno, 603 00, Czechia
| Brno, 636 00, Czechia
| Brno, 638 00, Czechia
| Brno, 639 00, Czechia
| Brno, 656 91, Czechia
| Broumov, 550 01, Czechia
| Choceň, 56501, Czechia
| Chrudim, 53701, Czechia
| Frýdek-Místek, 73801, Czechia
| Havirov, 763 01, Czechia
| Havlíčkův Brod, 580 22, Czechia
| Hodonín, 69501, Czechia
| Hradec Kralove, 50005, Czechia
| Hradec Králové, 500 02, Czechia
| Kolín, 28000, Czechia
| Náchod, 547 01, Czechia
| Olomouc, 77900, Czechia
| Ostrava, 70200, Czechia
| Pardubice, 530 02, Czechia
| Prague 5, 150 06, Czechia
| Prague, 158 00, Czechia
| Praha 10, 10100, Czechia
| Praha 1, 11000, Czechia
| Praha 2, 128 00, Czechia
| Praha 4 - Krc, 140 59, Czechia
| Praha 4, 140 21, Czechia
| Praha, 120 00, Czechia
| Přerov, 75002, Czechia
| Slaný, 274 01, Czechia
| Teplice, 41501, Czechia
| Trutnov, 541 01, Czechia
| Uherské Hradiště, 68601, Czechia
| Aalborg, 9000, Denmark
| Aalborg, 9100, Denmark
| Ballerup, 2750, Denmark
| Copenhagen NV, 2400, Denmark
| Esbjerg, 6700, Denmark
| Glostrup, 2600, Denmark
| Hellerup, 2900, Denmark
| Holbæk, 4300, Denmark
| Nykøbing Falster, 4800, Denmark
| Vejle, 7100, Denmark
| Viborg, 8800, Denmark
| Århus N, 8200, Denmark
| Tallinn, 10117, Estonia
| Tallinn, 10128, Estonia
| Tallinn, 10138, Estonia
| Tallinn, 13419, Estonia
| Bad Krozingen, Baden Wuerttemberg, 79189, Germany
| Dresden, Baden Wuerttemberg, 01307, Germany
| Heidelberg, Baden Wuerttemberg, 69115, Germany
| Munich, Bayern, 80809, Germany
| Wallerfing, Bayern, 94574, Germany
| Bad Homburg, Hessen, 61348, Germany
| Frankfurt am Main, Hessen, 65929, Germany
| Frankfurt, Hessen, 60313, Germany
| Frankfurt, Hessen, 60594, Germany
| Kassel, Hessen, 34121, Germany
| Rodgau, Hessen, 63110, Germany
| Mainz, Hesse, 55128, Germany
| Schwerin, Mecklenburg Vorpommern, 19055, Germany
| Bochum, Nordrhein Westfalen, 44787, Germany
| Dortmund, Nordrhein Westfalen, 44141, Germany
| Essen, Nordrhein Westfalen, 45355, Germany
| Goch, Nordrhein Westfalen, 47574, Germany
| Koeln, Nordrhein Westfalen, 50937, Germany
| Koeln, Nordrhein Westfalen, 51069, Germany
| Siegen, Nordrhein Westfalen, 57072, Germany
| Soest, Nordrhein Westfalen, 59494, Germany
| Witten, Nordrhein Westfalen, 58455, Germany
| Bielefeld, North Rhine-Westphalia, 33604, Germany
| Dortmund, North Rhine-Westphalia, 44137, Germany
| Essen, North Rhine-Westphalia, 45359, Germany
| Mainz, Rheinland Pfalz, 55131, Germany
| Bohlen, Sachsen, 04564, Germany
| Dippoldiswalde, Sachsen, 01744, Germany
| Dresden, Sachsen, 01099, Germany
| Dresden, Sachsen, 01277, Germany
| Dresden, Sachsen, 01279, Germany
| Dresden, Sachsen, 01307, Germany
| Leipzig, Sachsen, 04103, Germany
| Leipzig, Sachsen, 04249, Germany
| Markkleeberg, Sachsen, 04416, Germany
| Wermsdorf, Sachsen, 04779, Germany
| Zwenkau, Sachsen, 04442, Germany
| Altenburg, Saxony, 04600, Germany
| Bad Homburg, 61348, Germany
| Berlin, 10115, Germany
| Berlin, 10117, Germany
| Berlin, 10409, Germany
| Berlin, 10629, Germany
| Berlin, 10787, Germany
| Berlin, 12627, Germany
| Berlin, 13597, Germany
| Bielefeld, 33604, Germany
| Falkensee, 14612, Germany
| Frankfurt, 60389, Germany
| Hamburg, 22041, Germany
| Hamburg, 22143, Germany
| Hamburg, 22607, Germany
| Hannover, 30159, Germany
| Heidelberg, 69120, Germany
| Mainz, D-55128, Germany
| Reinfeld, 23858, Germany
| Orosháza, Szentetornya, 5905, Hungary
| Baja, 6500, Hungary
| Balatonfüred, H-8230, Hungary
| Balatongyörök, 8313, Hungary
| Budapest, 1033, Hungary
| Budapest, 1036, Hungary
| Budapest, 1037, Hungary
| Budapest, 1083, Hungary
| Budapest, 1085, Hungary
| Budapest, 1097, Hungary
| Budapest, 1121, Hungary
| Budapest, 1122, Hungary
| Budapest, 1125, Hungary
| Budapest, 1132, Hungary
| Budapest, 1134, Hungary
| Budapest, 1135, Hungary
| Békéscsaba, 5600, Hungary
| Debrecen, 4025, Hungary
| Debrecen, 4032, Hungary
| Dombovar, 7200, Hungary
| Gyula, 5700, Hungary
| Gyöngyös, 3200, Hungary
| Győr, 9024, Hungary
| Hajdúszoboszló, 4200, Hungary
| Kalocsa, 6300, Hungary
| Kecskemét, 8000, Hungary
| Kiskunhalas, 6400, Hungary
| Miskolc, 3530, Hungary
| Mosonmagyaróvár, H-9200, Hungary
| Nagykanizsa, 8800, Hungary
| Nyíregyháza, 4400, Hungary
| Nyíregyháza, H-4405, Hungary
| Orosháza, 5905, Hungary
| Polgar, 4090, Hungary
| Pécs, 7623, Hungary
| Pécs, 7635, Hungary
| Szekszard, 7100, Hungary
| Szentendre, 2000, Hungary
| Szentes, 6600, Hungary
| Szombathely, 9700, Hungary
| Székesfehérvár, 8000, Hungary
| Zalaegerszeg, 8900, Hungary
| Hyderabad, Andhra Pradesh, 500034, India
| Guwahati, Assam, 781006, India
| New Delhi, Delhi, 110002, India
| New Delhi, Delhi, 110005, India
| New Delhi, Delhi, 110070, India
| Ahmedabad, Gujarat, 380007, India
| Nadiād, Gujarat, 387002, India
| Surat, Gujarat, 395002, India
| Sūrat, Gujarat, 395002, India
| Sūrat, Gujarat, 395009, India
| Vadodara, Gujarat, 391740, India
| Faridabad, Haryana, 121001, India
| Gurgaon, Haryana, 122001, India
| Bangalore, Karnataka, 560010, India
| Bangalore, Karnataka, 560099, India
| Belgaum, Karnataka, 590010, India
| Bengaluru, Karnataka, 560074, India
| Hubli, Karnatak, 580021, India
| Aurangabad, Maharashtra, 431001, India
| Aurangabad, Maharashtra, 431005, India
| Nagpur, Maharashtra, 440003, India
| Nagpur, Maharashtra, 440010, India
| Nagpur, Maharashtra, 440012, India
| Nashik, Maharashtra, 422005, India
| Nashik, Maharashtra, 422007, India
| Pune, Maharashtra, 411001, India
| Pune, Maharashtra, 411004, India
| Pune, Maharashtra, 411005, India
| Jaipur, Rajasthan, 302001, India
| Jaipur, Rajasthan, 302020, India
| Chennai, Tamilnadu, 600037, India
| Coimbatore, Tamilnadu, 641009, India
| Lucknow, Uttar Pradesh, 226010, India
| Noida, Uttar Pradesh, 201301, India
| Kolkata, West Bengal, 700027, India
| Delhi, 110062, India
| Daugavpils, LV-5401, Latvia
| Kuldiga, LV-3301, Latvia
| Ogre, LV-5001, Latvia
| Riga, LV-1010, Latvia
| Riga, LV-1038, Latvia
| Riga, LV1002, Latvia
| Riga, LV1012, Latvia
| Tukums, LV-3101, Latvia
| Ventspils, LV-3601, Latvia
| Alytus, 62386, Lithuania
| Kaunas, 47144, Lithuania
| Kaunas, 48259, Lithuania
| Kaunas, 49387, Lithuania
| Kaunas, 49449, Lithuania
| Kaunas, LT-44001, Lithuania
| Kaunas, LT-50161, Lithuania
| Klaipėda, 91131, Lithuania
| Vilnius, 10323, Lithuania
| Vilnius, LT-08661, Lithuania
| Šiauliai, 76231, Lithuania
| Tijuana, Baja California Norte, 22500, Mexico
| Chihuahua, Chihuahua C.P., 31203, Mexico
| Monclova, Coahuila, 25750, Mexico
| Torreon, Coahuila, 27000, Mexico
| Mexico, Distrito Federal, 03100, Mexico
| Mexico, Distrito Federal, 03300, Mexico
| Mexico, Distrito Federal, 06100, Mexico
| Mexico, Distrito Federal, 06700, Mexico
| Mexico, Distrito Federal, 11650, Mexico
| Pachuca, Hidalgo, 42090, Mexico
| Guadalajara, Jalisco, 44160, Mexico
| Guadalajara, Jalisco, 44670, Mexico
| Monterrey, Nuevo León, 64660, Mexico
| Querétaro, Qro., 76000, Mexico
| Querétaro, Queretaro, 76000, Mexico
| Culiacan, Sinaloa, 80230, Mexico
| Culiacán, Sinaloa, 80200, Mexico
| Mazatlán, Sinaloa, 82110, Mexico
| Mérida, Yucatán, 97129, Mexico
| Aguascalientes, 20010, Mexico
| Aguascalientes, 20016, Mexico
| Aguascalientes, 20230, Mexico
| Chihuahua, 0, Mexico
| Chihuahua, 31217, Mexico
| Chihuahua, 4032, Mexico
| Cuernavaca, 62250, Mexico
| Durango, 34000, Mexico
| Guadalajara, 44160, Mexico
| Guadalajara, 44500, Mexico
| Guadalajara, 44657, Mexico
| Guadalajara, 44670, Mexico
| Juarez, 32472, Mexico
| Mexico City, 14080, Mexico
| Mexico City, 3100, Mexico
| Mexico City, 3720, Mexico
| Mexico City, 7760, Mexico
Bioné-IPHARMA | Monterrey, 64060, Mexico
SBHI "Penza Regional Clinical Hospital n.a. N.N. Burdenko" | Monterrey, 64060, Mexico
| Monterrey, 64060, Mexico
| Monterrey, 64460, Mexico
| Monterrey, 64718, Mexico
| Pachuca, 42070, Mexico
| Puerto Vallarta, 48328, Mexico
| Querétaro, 76090, Mexico
| Tamaulipas, C.P 89440, Mexico
| Veracruz, 91900, Mexico
| Alkmaar, 1815 JD, Netherlands
| Almelo, 7609 PP, Netherlands
| Almere, 1311 RL, Netherlands
| Amersfoort, 3813 TZ, Netherlands
| Amstelveen, 1186 AM, Netherlands
| Amsterdam, 1034 CS, Netherlands
| Amsterdam, 1066 EC, Netherlands
| Amsterdam, 1081 HV, Netherlands
| Amsterdam, 1091 AC, Netherlands
| Amsterdam, 1105 AZ, Netherlands
| Amsterdam, Netherlands
| Apeldoorn, 7334 DZ, Netherlands
| Apeldoorn, Netherlands
| Arnhem, 6815 AD, Netherlands
| Beverwijk, 1942 LE, Netherlands
| Blaricum, 1261 AN, Netherlands
| Delft, 2625 AD, Netherlands
| Den Haag, 2545 CH, Netherlands
| Den Haag, 2565 KV, Netherlands
| Den Haag, 2573 KH, Netherlands
| Dirksland, 3247 BW, Netherlands
| Doetinchem, 7009 BL, Netherlands
| Dordrecht, 3318 AT, Netherlands
| Ede, 6716 RP, Netherlands
| Eindhoven, 5623 EJ, Netherlands
| Enschede, 7512 KZ, Netherlands
| Goes, 4462 RA, Netherlands
| Gorinchem, 4204 AA, Netherlands
| Gouda, 2803 HH, Netherlands
| Gouda, 2803, Netherlands
| Hardenberg, 7772 SE, Netherlands
| Hardenberg, 7772, Netherlands
| Harderwijk, Netherlands
| Heerlen, 6419 PC, Netherlands
| Helmond, 5707 HA, Netherlands
| Hilversum, 1213 XZ, Netherlands
| Hoogeveen, 7909 AA, Netherlands
| Hoogezand, 9603 AE, Netherlands
| Hoorn, 1624 NP, Netherlands
| Leeuwarden, 8934 AD, Netherlands
| Leiden, 2333 ZA, Netherlands
| Leiderdorp, 2353 GA, Netherlands
| Maastricht, 6229 HX, Netherlands
| Nijmegen, 6525 GA, Netherlands
| Nijmegen, 6532 SZ, Netherlands
| Purmerend, 1441 RN, Netherlands
| Roosendaal, 4708 AE, Netherlands
| Rotterdam, 3037 AN, Netherlands
| Rotterdam, 3045 PM, Netherlands
| Rotterdam, 3067 GJ, Netherlands
| Rotterdam, 3079 DZ, Netherlands
| Rotterdam, 3083 AN, Netherlands
| Schiedam, 3118 JH, Netherlands
| Sneek, Netherlands
| Tiel, 4002 WP, Netherlands
| Tilburg, 5022, Netherlands
| Utrecht, 3511 NH, Netherlands
| Utrecht, 3582 KE, Netherlands
| Utrecht, 3584 CX, Netherlands
| Venlo, 5912 BL, Netherlands
| Zutphen, 7207, Netherlands
| Zwijndrecht, 3331 LZ, Netherlands
| Zwijndrecht, 3334 SB, Netherlands
| Zwolle, 8025 AB, Netherlands
| Auckland, 0600, New Zealand
| Auckland, 0620, New Zealand
| Auckland, 0626, New Zealand
| Auckland, 1010, New Zealand
| Christchurch, 8011, New Zealand
| Christchurch, 8024, New Zealand
| Grafton, 1023, New Zealand
| Hamilton, 3200, New Zealand
| Hastings, 4120, New Zealand
| New Plymouth, 4342, New Zealand
| Papamoa, 3118, New Zealand
| Rotorua, 3010, New Zealand
| Tauranga, 3110, New Zealand
| Tauranga, 3144, New Zealand
| Wellington, 6021, New Zealand
| Legnica, Dolnoslaskie, 59-220, Poland
| Wrocław, Dolnoslaskie, 51-314, Poland
| Wrocław, Dolnoslaskie, 53-301, Poland
| Włocławek, Kujawsko-Pomorskie, 87-800, Poland
| Lublin, Lubelski, 20-091, Poland
| Kraków, Małopolskie, 31-156, Poland
| Tarnów, Małopolskie, 33-100, Poland
| Katowice, Slaskie, 40-648, Poland
| Katowice, Sląskie, 40-018, Poland
| Katowice, Sląskie, 40-083, Poland
| Ruda Śląska, Sląskie, 41-709, Poland
| Białystok, 15-445, Poland
| Brzozów, 36, Poland
| Bydgoszcz, 85-231, Poland
| Bydgoszcz, 85, Poland
| Chełm, 22-100, Poland
| Częstochowa, 42-202, Poland
| Elbląg, 82-300, Poland
| Gdańsk, 80-382, Poland
| Gdańsk, 80-542, Poland
| Gdynia, 81-537, Poland
| Grodzisk Mazowiecki, 05-825, Poland
| Katowice, 40-040, Poland
| Katowice, 40, Poland
| Kielce, 25-364, Poland
| Krakow, 30082, Poland
| Krakow, 31, Poland
| Kraków, 31-261, Poland
| Kraków, 31, Poland
| Legnica, 59, Poland
| Lublin, 20-044, Poland
| Lublin, 20-709, Poland
| Nałęczów, 24-140, Poland
| Nowa Sól, 67-100, Poland
| Nowy Targ, 34, Poland
| Oświęcim, 32-600, Poland
| Poznań, 60-702, Poland
| Poznań, 60, Poland
| Poznań, 61-655, Poland
| Pulawy, 24-100, Poland
| Puławy, 24-100, Poland
| Płock, 09-400, Poland
| Ruda Śląska, 41-709, Poland
| Ruda Śląska, 41, Poland
| Rzeszów, 35-006, Poland
| Rzeszów, 35-055, Poland
| Rzeszów, 35, Poland
| Siedlce, 08-110, Poland
| Skierniewice, 96-100, Poland
| Sopot, 81-717, Poland
| Staszów, 28-200, Poland
| Szczecin, 71-434, Poland
| Szczecin, 71-531, Poland
| Tarnów, 33, Poland
| Tczew, 83, Poland
| Toruń, 87-100, Poland
| Warsaw, 00-465, Poland
| Warsaw, 04-730, Poland
| Warszawa, 01-192, Poland
| Warszawa, 02-793, Poland
| Wroclaw, 50, Poland
| Wroclaw, 51, Poland
| Wrocław, 50-381, Poland
| Wrocław, 53, Poland
| Włocławek, 87, Poland
| Zamość, 22-400, Poland
| Łódź, 15-445, Poland
| Łódź, 90-127, Poland
| Łódź, 90-302, Poland
| Łódź, 90-368, Poland
| Łódź, 90-549, Poland
| Łódź, 91-211, Poland
| Łódź, 93-513, Poland
| Łódź, 94-048, Poland
| Pitesti, Arges, 110084, Romania
| Baia Mare, Maramures County, 430032, Romania
| Satu Mare, Satu Mare County, 440055, Romania
| Timişoara, Timis County, 300456, Romania
| Alba Iulia, 510053, Romania
| Baia Mare, 430032, Romania
| Baia Mare, 430222, Romania
| Baloteşti, 077015, Romania
| Braila, 810249, Romania
| Braşov, 500283, Romania
| Braşov, 500326, Romania
| Bucharest, 010825, Romania
| Bucharest, 10825, Romania
| Bucharest, 20063, Romania
| Bucharest, 20614, Romania
| Bucharest, 4204178, Romania
| Bucuresti, 010192, Romania
| Bucuresti, 010825, Romania
| Bucuresti, 020045, Romania
| Bucuresti, 020125, Romania
| Bucuresti, 021659, Romania
| Bucuresti, 030088, Romania
| Bucuresti, 030463, Romania
| Bucuresti, 050659, Romania
| Bucuresti, 062272, Romania
| Calarasi, 910103, Romania
| Cluj-Napoca, 400496, Romania
| Craiova, 200500, Romania
| Deva, 330084, Romania
| Galaţi, 800001, Romania
| Galaţi, 800291, Romania
| Oradea, 410001, Romania
S.C Grandmed S.R.L | Oradea, 410159, Romania
| Oradea, 410159, Romania
| Oradea, 410167, Romania
| Oradea, 410491, Romania
| Paşcani, 705200, Romania
| Pitesti, 110084, Romania
| Ploieşti, 100342, Romania
| Satu Mare, 440055, Romania
| Timisoara, 300456, Romania
| Timişoara, 300362, Romania
| Timişoara, 300723, Romania
| Târgu-Mureş, 540099, Romania
| Târgu-Mureş, 540140, Romania
| Târgu-Mureş, 540142, Romania
| Târgu-Mureş, 540143, Romania
| Zalău, 450112, Romania
| Barnaul, Altayskiy Kray, 656038, Russian Federation
| Arkhangel'sk, 163001, Russian Federation
| Arkhangelsk, 163001, Russian Federation
| Barnaul, 656038, Russian Federation
| Chelyabinsk, 454021, Russian Federation
| Chelyabinsk, 454091, Russian Federation
| Ekaterinburg, 620028, Russian Federation
| Ekaterinburg, 620109, Russian Federation
| Ekaterinburg, 620144, Russian Federation
| Ivanovo, 153012, Russian Federation
| Kazan, 420012, Russian Federation
| Kemerovo, 650000, Russian Federation
| Kemerovo, 650002, Russian Federation
| Kemerovo, 650055, Russian Federation
| Kirovsk, 187340, Russian Federation
| Kirov, 610014, Russian Federation
| Kirov, 610027, Russian Federation
| Krasnoyarsk, 660062, Russian Federation
| Kursk, 305007, Russian Federation
| Kursk, 305035, Russian Federation
| Moscow, 109388, Russian Federation
| Moscow, 111539, Russian Federation
| Moscow, 115516, Russian Federation
| Moscow, 117593, Russian Federation
| Moscow, 119049, Russian Federation
| Moscow, 119620, Russian Federation
| Moscow, 121359, Russian Federation
| Moscow, 125299, Russian Federation
| Moscow, 125367, Russian Federation
| Moscow, 129090, Russian Federation
| Moscow, 129301, Russian Federation
| Nizhniy Novgorod, 603011, Russian Federation
| Novosibirsk, 630051, Russian Federation
| Novosibirsk, 630068, Russian Federation
| Novosibirsk, 630089, Russian Federation
| Novosibirsk, 630117, Russian Federation
| Omsk, 644018, Russian Federation
| Omsk, 644024, Russian Federation
| Orenburg, 460000, Russian Federation
| Perm, 614097, Russian Federation
| Rostov-on-Don, 344068, Russian Federation
| Ryazan', 390026, Russian Federation
| Ryazan', 390039, Russian Federation
| Saint Petersburg, 192148, Russian Federation
| Saint Petersburg, 192283, Russian Federation
| Saint Petersburg, 193318, Russian Federation
| Saint Petersburg, 194044, Russian Federation
| Saint Petersburg, 195067, Russian Federation
| Saint Petersburg, 195220, Russian Federation
| Saint Petersburg, 195271, Russian Federation
| Saint Petersburg, 196084, Russian Federation
| Saint Petersburg, 196105, Russian Federation
| Saint Petersburg, 196601, Russian Federation
| Saint Petersburg, 197022, Russian Federation
North-West Federal Medical Research Center n.a. V.A. Almazov | Saint Petersburg, 197341, Russian Federation
| Saint Petersburg, 197341, Russian Federation
| Saint Petersburg, 197376, Russian Federation
| Saint Petersburg, 198205, Russian Federation
| Saint Petersburg, 198328, Russian Federation
| Saint Petersburg, 198510, Russian Federation
| Saint Petersburg, 199106, Russian Federation
| Saint-Petersburg, 194156, Russian Federation
| Saint-Petersburg, 197022, Russian Federation
| Saratov, 410012, Russian Federation
| Sestroretsk, 197706, Russian Federation
| Smolensk, 214019, Russian Federation
| St. Petersburg, 196084, Russian Federation
| Tomsk, 634009, Russian Federation
| Tomsk, 634012, Russian Federation
| Yaroslavl, 150000, Russian Federation
| Yaroslavl, 150030, Russian Federation
| Yaroslavl, 150062, Russian Federation
| Belgrade, 11000, Serbia
| Belgrade, 11040, Serbia
| Belgrade, 11080, Serbia
| Kragujevac, 34000, Serbia
| Niš, 18000, Serbia
| Pančevo, 26000, Serbia
| Smederevo, 11300, Serbia
| Sremska Mitrovica, 22000, Serbia
| Užice, 31000, Serbia
| Valjevo, 14000, Serbia
| Zaječar, 19000, Serbia
| Bratislava 2, Ružinov, 82606, Slovakia
| Bardejov, 08501, Slovakia
| Bratislava, 81104, Slovakia
| Bratislava, 83101, Slovakia
| Bratislava, 84108, Slovakia
| Bratislava, 85101, Slovakia
| Dolný Kubín, 02601, Slovakia
| Komarno, 94501, Slovakia
| Košice, 040 22, Slovakia
| Košice, 04001, Slovakia
| Košice, 04011, Slovakia
| Košice, 4001, Slovakia
| Levice, 93401, Slovakia
| Levice, 93405, Slovakia
| Lucenec, 98401, Slovakia
| Lučenec, 984 01, Slovakia
| Lučenec, 98401, Slovakia
| Moldava Nad Bodvou, 045 01, Slovakia
| Nitra, 94901, Slovakia
| Nove Zamky, 94052, Slovakia
| Nové Zámky, 94052, Slovakia
| Prešov, 08001, Slovakia
| Rožňava, 048 01, Slovakia
| Sahy, 93601, Slovakia
| Svidnik, 08901, Slovakia
| Svidník, 08901, Slovakia
| Ľubochňa, 3491, Slovakia
| Štúrovo, 943 01, Slovakia
| Žilina, 01001, Slovakia
| Port Elizabeth, Eastern Cape, 6001, South Africa
| Port Elizabeth, Eastern Cape, 6014, South Africa
| Bloemfontein, Free State, 9300, South Africa
| Bloemfontein, Free State, 9301, South Africa
| Centurion, Gauteng, 0157, South Africa
| Johannesburg, Gauteng, 1401, South Africa
| Johannesburg, Gauteng, 2193, South Africa
| Johannesburg, Gauteng, 2196, South Africa
| Kempton Park, Gauteng, 1619, South Africa
| Pretoria, Gauteng, 0002, South Africa
| Pretoria, Gauteng, 0040, South Africa
| Pretoria, Gauteng, 0084, South Africa
| Pretoria, Gauteng, 0087, South Africa
| Pretoria, Gauteng, 0157, South Africa
| Pretoria, Gauteng, 0184, South Africa
| Pretoria, Gauteng, 1692, South Africa
| Alberton, Guateng, 1449, South Africa
| Pretoria, Guateng, 0002, South Africa
| Pretoria, Guateng, 0181, South Africa
| Durban, KwaZulu-Natal, 4001, South Africa
| Durban, KwaZulu-Natal, 4320, South Africa
| Durban, KwaZulu-Natal, 4339, South Africa
| Merebank, KwaZulu-Natal, 4052, South Africa
| Thabazimbi, Limpopo, 0380, South Africa
| Middelburg, Mpumalanga, 1055, South Africa
| Moloto, Mpumalanga, 1022, South Africa
| Cape Town, Western Cape, 7130, South Africa
| Cape Town, Western Cape, 7405, South Africa
| Cape Town, Western Cape, 7500, South Africa
| Cape Town, Western Cape, 7570, South Africa
| Cape Town, Western Cape, 7580, South Africa
| Cape Town, Western Cape, 7764, South Africa
| Cape Town, Western Cape, 7925, South Africa
| Somerset West, Western Cape, 7130, South Africa
| Worcester, Western Cape, 6850, South Africa
| Santiago De Compostela, La Coruña, 15706, Spain
| A Coruña, 15006, Spain
| Almeria, 04120, Spain
| Barcelona, 08003, Spain
| Barcelona, 08023, Spain
| Barcelona, 08025, Spain
| Barcelona, 08034, Spain
| Girona, 17005, Spain
| Madrid, 28007, Spain
| Madrid, 28034, Spain
| Málaga, 29010, Spain
| Sevilla, 41003, Spain
| Sevilla, 41010, Spain
| Sevilla, 41071, Spain
| Adana, 01330, Turkey
| Ankara, 06500, Turkey
| Antalya, 07059, Turkey
| Edirne, 22030, Turkey
| Eskisehir, 26480, Turkey
| Istanbul, 34394, Turkey
| Istanbul, 34846, Turkey
| Istanbul, 34890, Turkey
| Izmir, 35100, Turkey
| Kocaeli, 41380, Turkey
| Mersin, 33343, Turkey
| Sivas, 58140, Turkey
| Brovary, 07400, Ukraine
| Cherkasy, 18009, Ukraine
| Chernivtsi, 58000, Ukraine
| Dnipro, 49005, Ukraine
| Dnipro, 49006, Ukraine
| Dnipro, 49023, Ukraine
| Dnipro, 49038, Ukraine
| Ivano-Frankivs'k, 76008, Ukraine
| Ivano-Frankivs'k, 76018, Ukraine
| Ivano-Frankivsk, 76018, Ukraine
| Kharkiv, 61002, Ukraine
| Kharkiv, 61039, Ukraine
| Kharkiv, 61103, Ukraine
| Kharkiv, 61106, Ukraine
| Kharkiv, 61124, Ukraine
| Kharkiv, 61172, Ukraine
| Kharkiv, 61176, Ukraine
| Kyiv, 01023, Ukraine
| Kyiv, 01601, Ukraine
| Kyiv, 02002, Ukraine
| Kyiv, 02091, Ukraine
| Kyiv, 02166, Ukraine
| Kyiv, 02232, Ukraine
| Kyiv, 03037, Ukraine
| Kyiv, 03049, Ukraine
| Kyiv, 03110, Ukraine
| Kyiv, 03115, Ukraine
SI NSC M.D. Strazhesko Institute of Cardiology of NAMSU | Kyiv, 03680, Ukraine
| Kyiv, 03680, Ukraine
| Kyiv, 04050, Ukraine
| Kyiv, 04053, Ukraine
| Luts'k, 43024, Ukraine
| Lviv, 79011, Ukraine
| Lviv, 79015, Ukraine
| Mykolaiv, 54003, Ukraine
| Odesa, 65025, Ukraine
| Sumy, 40021, Ukraine
| Ternopil, 46010, Ukraine
| Vinnytsia, 21001, Ukraine
| Vinnytsia, 21005, Ukraine
| Vinnytsia, 21009, Ukraine
| Vinnytsia, 21018, Ukraine
| Vinnytsia, 21029, Ukraine
| Vinnytsya, 21009, Ukraine
| Zaporizhzhia, 60106, Ukraine
| Zaporizhzhia, 69001, Ukraine
| Zaporizhzhia, 69005, Ukraine
| Zaporizhzhia, 69063, Ukraine
| Zaporizhzhia, 69104, Ukraine
| Zaporizhzhia, 69600, Ukraine
Zhytomyr regional clinical hospital n.a. O.F. Gerbachevskyy | Zhytomyr, 10002, Ukraine
| Zhytomyr, 10002, Ukraine
| Úzhgorod, 88014, Ukraine
| Reading, Berkshire, RG2 0TG, United Kingdom
| Soham, Cambridgeshire, CB7 5JD, United Kingdom
| Fowey, Cornwall, PL23 1DT, United Kingdom
| Hayle, Cornwall, TR27 5DT, United Kingdom
| Torpoint, Cornwall, PL11 2TB, United Kingdom
| Exmouth, Devon, EX8 2JF, United Kingdom
| Plymouth, Devon, PL6 8DH, United Kingdom
| Plymouth, Devon, PL7 2QP, United Kingdom
| Stockton on Tees, Durham, TS19 8PE, United Kingdom
| Basildon, Essex, SS16 5NL, United Kingdom
| London, Greater London, EC1M 6BQ, United Kingdom
| Manchester, Greater Manchester, M15 6SX, United Kingdom
| East Kilbride, Lanarkshire, G75 8RG, United Kingdom
| Blackpool, Lancashire, FY4 3AD, United Kingdom
| Chorley, Lancashire, PR7 7NA, United Kingdom
| Edinburgh, Lothian Region, EH16 4SA, United Kingdom
| Liverpool, Merseyside, L22 0LG, United Kingdom
| Airdrie, North Lanarkshire, ML6 0JS, United Kingdom
| Hexham, Northumberland, NE46 1QJ, United Kingdom
| Axbridge, Somerset, BS26 2BJ, United Kingdom
| Bath, Somerset, BA3 2UH, United Kingdom
| Cardiff, South Glamorgan, CF15 9SS, United Kingdom
| Glasgow, Strathclyde, G20 OSP, United Kingdom
| Chertsey, Surrey, KT16 0PZ, United Kingdom
| Dundee, Tayside Region, DD1 9SY, United Kingdom
| Birmingham, West Midlands, B15 2SQ, United Kingdom
| Wakefield, Yorkshire And The Humber, WF1 4DG, United Kingdom
| Wakefield, Yorkshire, WF1 4DG, United Kingdom
| Blackpool, FY3 7EN, United Kingdom
| Chesterfield, S40 4AA, United Kingdom
| Crownhill, PL5 3JB, United Kingdom
| Leamington Spa, CV32 4RA, United Kingdom
| Lincoln, LN2 5QY, United Kingdom
| Oldham, OL1 2JH, United Kingdom
| Sandbach, CW11 1EQ, United Kingdom
| Whitby, YO21 1SD, United Kingdom
Location Countries

Argentina

Australia

Austria

Belgium

Brazil

Bulgaria

Canada

Chile

Colombia

Croatia

Czechia

Denmark

Estonia

Germany

Hungary

India

Latvia

Lithuania

Mexico

Netherlands

New Zealand

Poland

Romania

Russian Federation

Serbia

Slovakia

South Africa

Spain

Turkey

Ukraine

United Kingdom

United States

Verification Date

May 2020

Responsible Party

Responsible party type: Sponsor

Has Expanded Access No
Condition Browse
Number Of Arms 2
Arm Group

Arm group label: Bempedoic Acid 180 mg

Arm group type: Experimental

Description: Bempedoic acid 180 mg tablet taken orally, once daily.

Arm group label: Placebo Comparator

Arm group type: Placebo Comparator

Description: Matching placebo tablet taken orally, once daily

Acronym CLEAR Outcomes
Patient Data No
Study Design Info

Allocation: Randomized

Intervention model: Parallel Assignment

Primary purpose: Treatment

Masking: Triple (Participant, Investigator, Outcomes Assessor)

Source: ClinicalTrials.gov