Pemafibrate to Reduce Cardiovascular OutcoMes by Reducing Triglycerides IN patiENts With diabeTes (PROMINENT) (PROMINENT)

July 11, 2023 updated by: Kowa Research Institute, Inc.

The primary objective of the study is to determine whether pemafibrate administered twice daily will delay the time to first occurrence of any component of the clinical composite endpoint of:

nonfatal Myocardial Infarction (MI)
nonfatal ischemic stroke
coronary revascularization; or
Cardio Vascular (CV) death.

Study Overview

Status

Terminated

Conditions

Intervention / Treatment

Detailed Description

A multi-regional clinical trial with participating sites in the following countries. India is being conducted under a previous protocol version due to regulatory requirements.

Argentina
Brazil
Bulgaria
Canada
Colombia
Czech Republic
Denmark
France
Germany
Hungary
India
Israel
Japan
Mexico
Netherlands
Poland
Romania
Russian Federation
Slovakia
South Africa
Spain
Ukraine
United Kingdom
United States

Study Type

Interventional

Enrollment (Actual)

10544

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Argentina
- - Ciudad Autonoma Buenos Aires, Argentina, C1093AAS
    - Fundacion Favaloro
  - Ciudad Autonoma Buenos Aires, Argentina, 1406
    - Consultorio Dr. Litvak Bruno
  - Ciudad Autonoma Buenos Aires, Argentina, C1119ACN
    - CIPREC
  - Ciudad Autonoma Buenos Aires, Argentina, C1179AAB
    - Investigaciones Medicas IMOBA S.R.L
  - Ciudad Autonoma Buenos Aires, Argentina, C1425AGC
    - Centro Medico Dra Laura Maffei Investigacion Clinica Aplicada
  - Ciudad Autonoma Buenos Aires, Argentina, C1425DES
    - Cedic Centro de Investigaciones Clinicas
  - Ciudad Autonoma Buenos Aires, Argentina, C1428ART
    - Instituto Cardiovascular Buenos Aires
  - Ciudad Autonoma Buenos Aires, Argentina, C1430CKE
    - CCBR - Buenos Aires - AR
  - Cordoba, Argentina, X5003DCE
    - Instituto Médico DAMIC
  - Cordoba, Argentina, X5016KEH
    - Hospital Privado Centro Medico de Cordoba S.A
  - Cordoba, Argentina, X5000AAW
    - Inst. Privado de Inv. Clinicas de Cordoba
  - Cordoba, Argentina, X5020AAA
    - Clinica del Prado
  - Corrientes, Argentina, 3400
    - Instituto de Cardiología de Corrientes
  - Salta, Argentina, A4400CRC
    - Prevención Cardiovascular Salta
- Buenos Aires
  - Bahia Blanca, Buenos Aires, Argentina, B8001HXM
    - Hospital Italiano Regional del Sur
  - Bahia Blanca, Buenos Aires, Argentina, 8000
    - Hospital Interzonal General de Agudos Dr Jose Penna
  - Ciudad Autonoma Buenos Aires, Buenos Aires, Argentina, C1181ACH
    - Hospital Italiano
  - La Plata, Buenos Aires, Argentina, B1902AGY
    - CICLO
  - Mar del Plata, Buenos Aires, Argentina, B7600FYK
    - Centro de Investigaciones Medicas Mar del Plata
  - Mar del Plata, Buenos Aires, Argentina, B7600FZ
    - Instituto de Investigaciones Clinicas
  - San Nicolas, Buenos Aires, Argentina, B2900DMH
    - Instituto de Investigaciones Clinicas San Nicolás
  - San Nicolas, Buenos Aires, Argentina, B2900DPA
    - Instituto Clinico Metabolico
  - Vicente Lopez, Buenos Aires, Argentina, 1602
    - Clinica Olivos
- Ciudad Autonoma Buenos Aires
  - Caba, Ciudad Autonoma Buenos Aires, Argentina, C1419GEP
    - Hospital Sirio Libanes
  - Ciudad Autonoma de Bs. As., Ciudad Autonoma Buenos Aires, Argentina, C1180AAX
    - Sanatorio Guemes
  - Ciudad Autonoma de Buenos Aires, Ciudad Autonoma Buenos Aires, Argentina, C1120AAC
    - Centro Medico Viamonte SRL
  - Villa Luro, Ciudad Autonoma Buenos Aires, Argentina, C1440CFD
    - CEMEDIC - Centro de Especialidades Medicas
- Cordoba
  - San Vicente, Cordoba, Argentina, X5006CBI
    - Centro Medico Luquez
- Tucuman
  - San Miguel de Tucuman, Tucuman, Argentina, 4000
    - Axismed S.R.L.- Clínica Mayo
Brazil
- Distrito Federal
  - Brasília, Distrito Federal, Brazil, 70200-730
    - L2IP - Instituto de Pesquisas Clínicas Ltda.
  - Brasília, Distrito Federal, Brazil, 70390903
    - Hospital do Coração do Brasil
  - Brasília, Distrito Federal, Brazil, 70710-100
    - CECAP - Centro de Cardiologia Clínica
  - Brasília, Distrito Federal, Brazil, 70840-091
    - Hospital Universitário de Brasília
  - Brasília, Distrito Federal, Brazil, 71655-175
    - Clínica de Endocrinologia e Metabologia Ltda.
- Goiás
  - Goiânia, Goiás, Brazil, 74210-050
    - CARDIOINTERV Centro de Pesquisa S/S
  - Goiânia, Goiás, Brazil, 74223-130
    - Via Médica
  - Goiânia, Goiás, Brazil, 74605-020
    - HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás
- Minas Gerais
  - Belo Horizonte, Minas Gerais, Brazil, 30110-060
    - Hospital Felicio Rocho
  - Belo Horizonte, Minas Gerais, Brazil, 30150-240
    - Cardresearch - Cardiologia Assistencial
- Paraná
  - Campina Grande do Sul, Paraná, Brazil, 83430-000
    - Sociedade Hospitalar Angelina Caron
  - Curitiba, Paraná, Brazil, 80030-480
    - Cline Research Center (Leite PS Consultoria Medica LTDA)
  - Curitiba, Paraná, Brazil, 80730-150
    - Núcleo de Pesquisa Clínica S/S
  - Maringá, Paraná, Brazil, 87015-000
    - Paraná Medical Research Center
- Pará
  - Belém, Pará, Brazil, 66073-000
    - HUJBB-UFPA - Hospital Universitário João de Barros Barreto - Universidade Federal do Pará
- Rio Do Janeiro
  - Rio de Janeiro, Rio Do Janeiro, Brazil, 22271-100
    - CCBR Brasil Centro de Pesquisas e Análises Clínicas Ltda.
- Rio Grande Do Norte
  - Natal, Rio Grande Do Norte, Brazil, 59020-500
    - Eurolatino Natal Pesquisas Médicas Ltda.
- Rio Grande Do Sul
  - Canoas, Rio Grande Do Sul, Brazil, 92425-900
    - Hospital Universitario
  - Passo Fundo, Rio Grande Do Sul, Brazil, 99010-080
    - Hospital Sao Vicente de Paulo
  - Pelotas, Rio Grande Do Sul, Brazil, 96015-290
    - Santa Casa de Misericordia de Pelotas
  - Porto Alegre, Rio Grande Do Sul, Brazil, 90035-903
    - Hospital de Clínicas de Porto Alegre
  - Porto Alegre, Rio Grande Do Sul, Brazil, 90035-074
    - Santa Casa de Misericordia de Porto Alegre
  - Porto Alegre, Rio Grande Do Sul, Brazil, 90430-001
    - Centro de Pesquisas em Diabetes Ltda.
  - Porto Alegre, Rio Grande Do Sul, Brazil, 90480-000
    - Centro de Pesquisa Clínica Maimônides - Maimônides Day Hospital
  - Santa Maria, Rio Grande Do Sul, Brazil, 97015-530
    - Centro de Pesquisa Médica Santa Maria Ltda.
- Santa Catarina
  - Blumenau, Santa Catarina, Brazil, 89010-906
    - Maestri e Kormann Consultoria Medico Científica LTDA
- Sao Paulo
  - Campinas, Sao Paulo, Brazil, 13010-001
    - Loema - Instituto de Pesquisa Clinica
  - Campinas, Sao Paulo, Brazil, 13060-080
    - IPCC - Instituto de Pesquisa Clínica de Campinas
  - São Bernardo do Campo, Sao Paulo, Brazil, 09780-000
    - CEMEC - Centro Multidisciplinar de Estudos Clínicos
  - São José do Rio Preto, Sao Paulo, Brazil, 15090-000
    - Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto
  - São José dos Campos, Sao Paulo, Brazil, 12243-280
    - ISPEM - Instituto São José dos Campos em Pesquisas Médicas
  - São Paulo, Sao Paulo, Brazil, 01228-000
    - CPQuali Pesquisa Clínica Ltda.
  - São Paulo, Sao Paulo, Brazil, 01228-200
    - CPCLIN - Centro de Pesquisas Clínicas Ltda.
  - São Paulo, Sao Paulo, Brazil, 01323-000
    - Clínica Paulista de Doenças Cardiovasculares Ltda.
  - São Paulo, Sao Paulo, Brazil, 04208-002
    - Dr. Consulta
  - São Paulo, Sao Paulo, Brazil, 04266-010
    - CEPIC - Centro Paulista de Investigação Clínica e Serviços Médicos
  - São Paulo, Sao Paulo, Brazil, 05403-000
    - Hospital das Clínicas da Faculdade de Medicina da USP
  - São Paulo, Sao Paulo, Brazil, 05403-000
    - Incor - Instituto do Coração - HCFMUSP
  - Tatuí, Sao Paulo, Brazil, 18270-170
    - IMC - Instituto de Moléstias Cardiovasculares Tatuí
  - Votuporanga, Sao Paulo, Brazil, 15500-003
    - Santa Casa de Votuporanga
Bulgaria
- - Blagoevgrad, Bulgaria, 2700
    - MHAT 'Puls' AD
  - Blagoevgrad, Bulgaria, 2700
    - MHAT - Blagoevgrad, EOOD
  - Byala, Bulgaria, 7100
    - MHAT "Yuliya Vrevska - Byala", EOOD
  - Haskovo, Bulgaria, 6300
    - MHAT-Haskovo, AD
  - Pazardzhik, Bulgaria, 4400
    - MHAT - Pazardzhik AD
  - Pazardzhik, Bulgaria, 4400
    - MHAT "Higia", AD - Pazardzhik
  - Pleven, Bulgaria, 5800
    - UMHAT 'Dr. Georgi Stranski', EAD
  - Pleven, Bulgaria, 5800
    - MHAT "Sv. Pantaleymon - Pleven", OOD
  - Pleven, Bulgaria, 5800
    - SHATC Pleven EAD
  - Plovdiv, Bulgaria, 4000
    - UMHAT "Sv. Georgi", EAD
  - Plovdiv, Bulgaria, 4002
    - UMHAT "Kaspela", EOOD
  - Ruse, Bulgaria, 7013
    - MC Rusemed ltd.
  - Sofia, Bulgaria, 1309
    - MHAT - "National Heart Hospital" EAD
  - Sofia, Bulgaria, 1233
    - NMTH "Tsar Boris III"
  - Sofia, Bulgaria, 1336
    - MHAT "Lyulin", EAD
  - Sofia, Bulgaria, 1527
    - UMHAT 'Tsaritsa Yoanna - ISUL', EAD
  - Sofia, Bulgaria, 1606
    - Fourth MHAT - Sofia EAD
  - Sofia, Bulgaria, 1784
    - MC "Synexus - Sofia", EOOD
  - Sofia, Bulgaria, 1407
    - Acibadem City Clinic Tokuda Hospital Ead
  - Sofia, Bulgaria, 1233
    - Fifth MHAT - Sofia EAD
  - Sofia, Bulgaria, 1750
    - UMHAT 'Sveta Anna' AD
  - Sofia, Bulgaria, 1797
    - UMHAT "SofiaMed", OOD
  - Sofia, Bulgaria, 1431
    - UMHAT "Alexandrovska" EAD
  - Sofia, Bulgaria, 1431
    - DCC "Alexandrovska", EOOD
  - Sofia, Bulgaria, 1680
    - Diagnostic Consultation Center CONVEX EOOD
  - Sofia, Bulgaria, 1040
    - Diagnostic Consultative Center II - Sofia OOD
  - Sofia, Bulgaria, 1408
    - MC Start - d-r Todor Dimitrov EOOD
  - Sofia, Bulgaria, 1680
    - Medical Center Kalimat
  - Stara Zagora, Bulgaria, 6000
    - MC "Orfey", EOOD
  - Varna, Bulgaria, 9000
    - SHATC "Cardiolife", OOD
  - Varna, Bulgaria, 9002
    - SHATC - Varna, EOOD
  - Yambol, Bulgaria, 8600
    - MHAT "Sv. Panteleymon", AD
Canada
- - Quebec, Canada, G1N 4V3
    - Diex Recherche Quebec Inc.
  - Quebec, Canada, G1V 4M6
    - Clinique des Maladies Lipidiques de Québec
  - Quebec, Canada, G1V 4G5
    - Institut Universitaire de Cardiologie et de Pneumologie de Quebec
- Alberta
  - Calgary, Alberta, Canada, T2H 2G4
    - LMC Clinical Research Inc. (Calgary)
  - Edmonton, Alberta, Canada, T5A 4L8
    - ALTA Clinical Research Inc.
  - Edmonton, Alberta, Canada, T5H 3V9
    - Royal Alexandra Hospital, CK Hui Heart Centre
  - Red Deer, Alberta, Canada, T4N 6V7
    - The Bailey Clinic
- British Columbia
  - New Westminster, British Columbia, Canada, V3L 3W4
    - Fraser Clinical Trials Inc.
  - Surrey, British Columbia, Canada, V3V 0C6
    - Surrey Memorial Hospital
  - Vancouver, British Columbia, Canada, V5Y 3W2
    - BC Diabetes As Operated by Dr. TG Elliott, Inc.
  - Victoria, British Columbia, Canada, V8T 5G4
    - Discovery Clinical Services Ltd.
- Manitoba
  - Winnipeg, Manitoba, Canada, R2H 2A6
    - Saint Boniface General Hospital
  - Winnipeg, Manitoba, Canada, R2V 4W3
    - Rivergrove Medical Clinic
  - Winnipeg, Manitoba, Canada, R3A 1R9
    - Winnipeg Clinic
- Newfoundland and Labrador
  - St. John's, Newfoundland and Labrador, Canada, NL A1B 3V6
    - Health Sciences Centre
- Ontario
  - Barrie, Ontario, Canada, L4N 7L3
    - LMC Clinical Research Inc. (Barrie)
  - Brampton, Ontario, Canada, L6T 0G1
    - Aggarwal and associates Ltd
  - Brampton, Ontario, Canada, L6S 0C9
    - LMC Clinical Research Inc. (Brampton)
  - Burlington, Ontario, Canada, L7M 4Y1
    - JBN Medical Diagnostic Services Inc.
  - Burlington, Ontario, Canada, L7M 4Y1
    - LMC Clinical Research dba Manna Research Inc. Burlington North
  - Cambridge, Ontario, Canada, N1R 6V6
    - Cambridge Cardiac Care Centre
  - Cambridge, Ontario, Canada, N1R 7L6
    - Joanne F. Liutkus Medicine Professional Corporation
  - Cambridge, Ontario, Canada, N1R 7R1
    - Saul Vizel Professional Medicine Corporation
  - Concord, Ontario, Canada, L4K 4M2
    - LMC Clinical Research Inc. (Thornhill)
  - Etobicoke, Ontario, Canada, M9R 4E1
    - LMC Clinical Research Inc. (Etobicoke)
  - Guelph, Ontario, Canada, N1H 1B1
    - Dawson Road Family Medical Clinic
  - Nepean, Ontario, Canada, K2J 0V2
    - LMC Clinical Research Inc. (Ottawa)
  - Oakville, Ontario, Canada, L6M1M1
    - LMC Clinical Research Inc. (Oakville)
  - Oshawa, Ontario, Canada, L1J 2K1
    - James Cha, MD
  - Ottawa, Ontario, Canada, K1H 7W9
    - The Ottawa Hospital - Riverside Campus
  - Peterborough, Ontario, Canada, K9J 0B2
    - Kawartha Cardiology Clinical Trials
  - Scarborough, Ontario, Canada, M1E 5E9
    - Scarborough Cardiology Research
  - Sudbury, Ontario, Canada, P3E 5M4
    - Janik Research
  - Toronto, Ontario, Canada, M5B 1W8
    - St. Michael's Hospital
  - Toronto, Ontario, Canada, M4G 3E8
    - LMC Clinical Research Inc. (Bayview)
  - Toronto, Ontario, Canada, M3M 0B2
    - Humber River Hospital
  - Toronto, Ontario, Canada, M9W 4L6
    - LMC Clinical Research dba Manna Research Inc. Toronto
- Quebec
  - Chicoutimi, Quebec, Canada, G7H 7K9
    - Ecogene-21
  - Greenfield Park, Quebec, Canada, J4V 2G8
    - ViaCar Recherche Clinique Inc
  - Longueuil, Quebec, Canada, J4M 2X1
    - Centre de Dépistage et Recherche Cardiovasculaire Rive-Sud
  - Lévis, Quebec, Canada, G6V 4Z5
    - Clinique de Cardiologie de Lévis
  - Mirabel, Quebec, Canada, J7J 2K8
    - LMC Clinical Research dba Manna Research Inc. Mirabel
  - Montreal, Quebec, Canada, H2W 1T8
    - CHUM Hôtel-Dieu
  - Montreal, Quebec, Canada, H4A 3T2
    - Applied Medical Informatics Research Inc.
  - Montréal, Quebec, Canada, H1T 3Y7
    - Clinique Sante Cardio MC
  - Québec, Quebec, Canada, G3K 2P8
    - ALPHA Recherche Clinique
  - Québec, Quebec, Canada, G1G 3Y8
    - Recherche Clinique Sigma Inc.
  - Québec, Quebec, Canada, G1W 4R4
    - Clinique Médicale St-Louis (Recherche) inc d/b/a/ Centre de Recherche Saint-Louis
  - Saint-Laurent, Quebec, Canada, H4T 1Z9
    - LMC Clinical Research Inc. (Montreal)
  - St-Jérôme, Quebec, Canada, J7Z 5T3
    - Recherche Medicale St-Jerome Inc.
  - St-Marc-des-Carrieres, Quebec, Canada, G0A 4B0
    - Centre Medical des Carrieres
Colombia
- - Barranquilla, Colombia, 080020
    - Centro de Investigacion Medico Asistencial S.A.S
  - Barranquilla, Colombia, 080020
    - IPS Centro Cientifico Asistencial S.A.S
  - Bogota, Colombia, 110221
    - Solano y Terront Servicios Médicos Ltda.
  - Bogota, Colombia, 110221
    - Dexa Diab Servicios Médicos Limitada.
  - Cartagena, Colombia, 130010
    - Centro Cardiovascular Aristides Sotomayor Santa Lucia S.A.S. - IPS ASTALUC S.A.S. IPS
  - Espinal, Colombia, 00000
    - Fundación Centro de Investigaciones Biomédicas Riescard
  - Floridablanca, Colombia, 681004
    - Fundacion Oftalmologica De Santander - Foscal
  - Medellin, Colombia, 050021
    - Centro de Investigación Clínica CIC
Czechia
- - Beroun, Czechia, 266 01
    - Medicentrum Beroun spol. s.r.o.
  - Brno, Czechia, 65691
    - Fakultni nemocnice u sv. Anny v Brne
  - Brno, Czechia, 639 00
    - Nemocnice Milosrdnych bratri
  - Broumov, Czechia, 550 01
    - EDUMED s.r.o
  - Chocen, Czechia, 56501
    - Poliklinika Chocen a.s.
  - Chomutov, Czechia, 430 02
    - Ordinace pro choroby srdce s.r.o.
  - Chrudim, Czechia, 537 01
    - MUDr. Jan Hubac s.r.o.
  - Havlickuv Brod, Czechia, 580 22
    - Nemocnice Havlickuv Brod p.o.
  - Hradec Kralove, Czechia, 500 02
    - Kardio-Pisova s.r.o.
  - Krnov, Czechia, 794 01
    - MUDr. Tomas Edelsberger
  - Nachod, Czechia, 547 01
    - EDUMED s.r.o
  - Olomouc, Czechia, 772 00
    - Agentura Science Pro Spol. s.r.o.
  - Olomouc, Czechia, 77900
    - PreventaMed s.r.o.
  - Ostrava, Czechia, 702 00
    - CCR Ostrava s.r.o.
  - Prague, Czechia, 158 00
    - Corintez s.r.o.
  - Praha, Czechia, 120 00
    - Synexus Czech s.r.o.
  - Praha 1, Czechia, 110 00
    - Nemocnice Na Frantisku
  - Praha 10, Czechia, 101 00
    - MUDr. Jan KVASNICKA CSc. Angiologie kardiologie a interna
  - Praha 2, Czechia, 128 00
    - Vseobecna fakultni nemocnice v Praze
  - Praha 8, Czechia, 18100
    - ResTrial s.r.o.
  - Rakovnik, Czechia, 269 01
    - MUDr.Eva Mandakova MBA
  - Slany, Czechia, 274 01
    - Nemocnice Slany
  - Teplice, Czechia, 415 01
    - AeskuLab k.s.
  - Trutnov, Czechia, 541 01
    - Kardiologicka ambulance MUDr. Ferkl s.r.o.
  - Uherske Hradiste, Czechia, 68601
    - Clinical Trials Services s.r.o
  - Uherske Hradiste, Czechia, 68601
    - MUDr. Nina Zemkova s.r.o.
Denmark
- - Aalborg, Denmark, 9100
    - Ålborg Universitets Hospital
  - Aalborg, Denmark, 9000
    - Bioclinica
  - Aarhus, Denmark, 8200
    - Aarhus University Hospital
  - Ballerup, Denmark, 2750
    - Bioclinica
  - Copenhagen S, Denmark, 2300
    - Amager-Hvidovre Hospital
  - Esbjerg, Denmark, 6700
    - Sydvestjyds Sygehus Esbjerg
  - Glostrup, Denmark, 2600
    - Amager-Hvidovre Hospital
  - Hellerup, Denmark, 2900
    - Herlev Og Gentofte Hospital
  - Herlev, Denmark, 2730
    - Herlev Og Gentofte Hospital
  - Herning, Denmark, 7400
    - Regionshospitalet Herning-Hospitalsenheden Vest
  - Holbæk, Denmark, 4300
    - Holbæk Sygehus
  - Roskilde, Denmark, 4000
    - Sjællands Universitetshospital
  - Svendborg, Denmark, 5700
    - OUH
  - Vejle, Denmark, 7100
    - Bioclinica
France
- Indre Et Loire
  - Chambray Les Tours, Indre Et Loire, France, 37170
    - CHU Tours - Hôpital Trousseau
- Loire Atlantique
  - Nantes cedex 01, Loire Atlantique, France, 44093
    - CHU Nantes - Hopital Nord Laennec
- Paris
  - Paris cedex 18, Paris, France, 75877
    - Hôpital Bichat - Claude Bernard
Germany
- - Berlin, Germany, 10409
    - Diabetespraxis Prenzlauer Allee
  - Berlin, Germany, 12627
    - Synexus Clinical Research GmbH
  - Berlin, Germany, 10437
    - Institut fuer klinische Forschung und Entwicklung Berlin GmbH
  - Berlin, Germany, 10789
    - Studienzentrum Rankestrasse
  - Hamburg, Germany, 22607
    - Gemeinschaftspraxis fuer innere Medizin und Diabetologie
- Baden Wuerttemberg
  - Freiburg, Baden Wuerttemberg, Germany, 79106
    - Universitaetsklinikum Freiburg
  - Villingen-Schwenningen, Baden Wuerttemberg, Germany, 78048
    - Praxis fuer Praevention und Therapie
- Bayern
  - Kuenzing, Bayern, Germany, 94550
    - Gemeinschaftspraxis Dr. Klein/ Minnich
  - Muenchen, Bayern, Germany, 80336
    - Klinikum der Universitaet Muenchen
  - Muenchen, Bayern, Germany, 80636
    - Deutsches Herzzentrum Muenchen
  - Naumburg, Bayern, Germany, 90402
    - GP Dr. Haggenmiller, PD Dr. Michael Jeserich
- Brandenburg
  - Elsterwerda, Brandenburg, Germany, 04910
    - ZKS-Südbrandenburg -center for clinical studies Südbrandenburg GmbH
- Hessen
  - Bad Homburg, Hessen, Germany, 61348
    - Neurologische Praxis Dr. Schoell & Kollegen
  - Frankfurt, Hessen, Germany, 60313
    - Synexus Clinical Research GmbH
  - Frankfurt, Hessen, Germany, 60596
    - ClinPhenomics GmbH & Co KG
- Mecklenburg Vorpommern
  - Schwerin, Mecklenburg Vorpommern, Germany, 19055
    - Klinische Forschung Schwerin GmbH
- Nordrhein Westfalen
  - Bochum, Nordrhein Westfalen, Germany, 44787
    - Synexus Clinical Research GmbH
  - Dortmund, Nordrhein Westfalen, Germany, 44137
    - St. Johannes Hospital
  - Dortmund, Nordrhein Westfalen, Germany, 44137
    - Gemeinschaftspraxis Diabeteszentrum Dortmund Dr.med. Klaus Busch
  - Dortmund, Nordrhein Westfalen, Germany, 44137
    - Kardiologische Praxis Gemeinschaftspraxis
  - Dortmund, Nordrhein Westfalen, Germany, 44139
    - Klinikum Bielefeld gem. GmbH
  - Siegen, Nordrhein Westfalen, Germany, 57072
    - Zentrum fuer Praevention und Rehabilitation
- Sachsen
  - Leipzig, Sachsen, Germany, 04103
    - Synexus Clinical Research GmbH
  - Leipzig, Sachsen, Germany, 04249
    - Gemeinschaftspraxis Dr. Taeschner / Dr. Bonigut
- Schleswig Holstein
  - Neumünster, Schleswig Holstein, Germany, 24534
    - Dr. Uwe Böckmann / Birgit Jacobs - Diabeteszentrum Neumünster
  - Oldenburg, Schleswig Holstein, Germany, 23758
    - RED - Institut GmbH
- Thueringen
  - Erfurt, Thueringen, Germany, 99097
    - Katholisches Krankenhaus "St. Johann Nepomuk"
Hungary
- - Baja, Hungary, 6500
    - Principal SMO Kft.
  - Baja, Hungary, 6500
    - Lausmed Kft.
  - Balatonfured, Hungary, 8230
    - DRC Gyogyszervizsgalo Kozpont Kft.
  - Bekescsaba, Hungary, 5600
    - Békés Megyei Központi Kórház Dr. Réthy Pál Tagkórház
  - Bekescsaba, Hungary, 5600
    - Belgyogyaszati es Kardiologiai Maganrendelo
  - Budapest, Hungary, 1083
    - Semmelweis Egyetem
  - Budapest, Hungary, 1033
    - Clinexpert Kft.
  - Budapest, Hungary, 1036
    - Synexus Magyarorszag Kft.
  - Budapest, Hungary, 1083
    - CSALADGYOGYASZ Kft.
  - Debrecen, Hungary, 4032
    - Debreceni Egyetem
  - Debrecen, Hungary, 4025
    - Borvo Clinic Kft.
  - Godollo, Hungary, 2100
    - Meditoll Kft.
  - Gyula, Hungary, 5700
    - Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaza
  - Gyula, Hungary, 5700
    - Synexus Magyarorszag Egeszsegugyi Szolgaltato Kft.- Gyula DRS
  - Hatvan, Hungary, 3000
    - BKS Research Kft.
  - Kalocsa, Hungary, 6300
    - Z+P MED Egeszsegugyi, Kereskedelmi es Szolgaltato Bt.
  - Kaposvar, Hungary, 7400
    - Somogy Megyei Kaposi Mor Oktato Korhaz
  - Komarom, Hungary, 2900
    - Selye Janos Korhaz
  - Miskolc, Hungary, 3530
    - IPR Hungary Kft.
  - Nagykanizsa, Hungary, 8800
    - Kanizsai Dorottya Korhaz
  - Nyiregyhaza, Hungary, 4400
    - Medifarma-98 Kft.
  - Nyiregyhaza, Hungary, H-4405
    - Borbanya Praxis Kft.
  - Oroshaza, Hungary, 5900
    - Dr. Nagy Laszlo Kardiologiai Maganrendeles
  - Pecs, Hungary, 7635
    - Da Vinci Maganklinika
  - Szekesfehervar, Hungary, 8000
    - Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz
  - Szekszard, Hungary, 7100
    - Tolna Megyei Balassa Janos Korhaz
  - Veszprem, Hungary, 8200
    - Csolnoky Ferenc Korhaz
  - Zalaegerszeg, Hungary, 8900
    - Zala Megyei Szent Rafael Korhaz
India
- - Delhi, India, 110052
    - Maharaja Agrasen Hospital
- Andhra Pradesh
  - Nellore, Andhra Pradesh, India, 524001
    - Vijaya Super Speciality Hospital
- Assam
  - Guwahati, Assam, India, 781006
    - GNRC Hospital
- Delhi
  - New Delhi, Delhi, India, 110060
    - Sir Gangaram Hospital
  - New Delhi, Delhi, India, 110002
    - Loknayak Hospital
  - New Delhi, Delhi, India, 110070
    - Fortis Flight Lieutenant Rajan Dhall Hospital
- Gujarat
  - Ahmedabad, Gujarat, India, 380015
    - Ahmedabad Bariatrics and Cosmetics Pvt Ltd.
  - Ahmedabad, Gujarat, India, 380054
    - S. A. L. Hospital & Medical Institute
  - Nadiad, Gujarat, India, 387002
    - DDMM Heart Institute
  - Surat, Gujarat, India, 395009
    - BAPS Pramukhswami Hospital
  - Surat, Gujarat, India, 395002
    - Shri B. D. Mehta Mahavir Heart Institute
  - Vadodara, Gujarat, India, 390007
    - Sterling Hospital
  - Vadodara, Gujarat, India, 391740
    - Rhythm Heart Institute
- Haryana
  - Gurgaon, Haryana, India, 122001
    - Medanta The Medicity
- Karnataka
  - Bangalore, Karnataka, India, 560052
    - Fortis Hospitals Ltd.
  - Belgaum, Karnataka, India, 590010
    - K.L.E. Society's Dr. Prabhakar Kore Hospital and Medical Research Centre
  - Mysuru, Karnataka, India, 570004
    - JSS Hospital
- Kerala
  - Thiruvananthapuram, Kerala, India, 695 011
    - Medical College
- Maharashtra
  - Nagpur, Maharashtra, India, 440010
    - Meditrina Institute of Medical Sciences
  - Nashik, Maharashtra, India, 422002
    - Supe Heart & Diabetes Hospital & Research Centre
  - Pimpri-Chinchwad, Maharashtra, India, 411033
    - 7-Orange Hospital
  - Pune, Maharashtra, India, 411006
    - Shree Multispecialty Hospital
  - Pune, Maharashtra, India, 411011
    - King Edward Memorial Hospital Research Centre
  - Ulhasnagar, Maharashtra, India, 421001
    - Aashirwad Hospital
- Orissa
  - Bhubaneshwar, Orissa, India, 751003
    - Institute of Medical Sciences and SUM Hospital
- Rajasthan
  - Jaipur, Rajasthan, India, 302020
    - Eternal Heart Care Centre
- Tamilnadu
  - Chennai, Tamilnadu, India, 600026
    - SRM Institutes for Medical Sciences
  - Chennai, Tamilnadu, India, 600037
    - Institute of Cardiovascular Diseases Madras Medical Mission
- Uttar Pradesh
  - Lucknow, Uttar Pradesh, India, 226010
    - KRM Hospital & Research Centre
  - Varanasi, Uttar Pradesh, India, 221010
    - Galaxy Hospital
- West Bengal
  - Kolkata, West Bengal, India, 700020
    - IPGMER and SSKM Hospital
Israel
- - Afula, Israel, 18101
    - Haemek medical center
  - Haifa, Israel, 34362
    - The Lady Davis Carmel Medical Center
  - Haifa, Israel, 31048
    - Bnai Zion Medical Center
  - Haifa, Israel, 3109601
    - Rambam Health Care Center
  - Holon, Israel, 58100
    - Wolfson medical center
  - Jerusalem, Israel, 91031
    - Shaare Zedek Medical Center
  - Jerusalem, Israel, 91120
    - Hadassah University Hospital - Ein Kerem
  - Nahariya, Israel, 2210001
    - Galilee Medical Center
  - Petach Tikva, Israel, 49100
    - Rabin Medical Center-Beilinson Campus
  - Ramat-Gan, Israel, 52621
    - Chaim Sheba Medical Center
  - Rechovot, Israel, 7610001
    - Kaplan Medical Center
  - Safed, Israel, 13100
    - Ziv Medical Center
  - Tel Aviv, Israel, 6423906
    - Tel Aviv Sourasky Medical Center
  - Tel Aviv, Israel, 6937947
    - Diabetes Medical Center
Japan
- Aichi-Ken
  - Nagakute-shi, Aichi-Ken, Japan, 480-1195
    - Aichi Medical University Hospital
  - Nagoya-shi, Aichi-Ken, Japan, 460-0001
    - NHO Nagoya Medical Center
  - Nagoya-shi, Aichi-Ken, Japan, 455-8530
    - JOHAS Chubu Rosai Hospital
  - Nagoya-shi, Aichi-Ken, Japan, 457-8511
    - Kojunkai Daido Clinic
  - Obu-shi, Aichi-Ken, Japan, 474-8511
    - National Center for Geriatrics and Gerontology
  - Toyoake-shi, Aichi-Ken, Japan, 470-1192
    - Fujita Health University Hospital
- Chiba-Ken
  - Chiba-shi, Chiba-Ken, Japan, 260-8677
    - Chiba University Hospital
  - Matsudo-shi, Chiba-Ken, Japan, 270-2251
    - Kioroshikai Chibanishi General Hospital
  - Matsudo-shi, Chiba-Ken, Japan, 271-0077
    - Seikeikai New Tokyo Heart Clinic
- Ehime-Ken
  - Matsuyama-shi, Ehime-Ken, Japan, 790-0024
    - Ehime Prefectural Central Hospital
- Fukuoka
  - Onga-gun, Fukuoka, Japan, 807-0051
    - Chiyukai Fukuoka Shinmizumaki Hospital
- Fukuoka-Ken
  - Fukuoka-shi, Fukuoka-Ken, Japan, 814-0180
    - Fukuoka University Hospital
  - Kasuga-shi, Fukuoka-Ken, Japan, 816-0864
    - Fukuoka Tokushukai Hospital
  - Kitakyushu-shi, Fukuoka-Ken, Japan, 805-8508
    - Steel Memorial Yawata Hospital
  - Koga-shi, Fukuoka-Ken, Japan, 811-3195
    - NHO Fukuoka Higashi Medical Center
- Fukushima-Ken
  - Koriyama-shi, Fukushima-Ken, Japan, 963-8052
    - Southern Tohoku Medical Clinic
  - Koriyama-shi, Fukushima-Ken, Japan, 963-8501
    - Hoshi general hospital
- Hiroshima-Ken
  - Fuchu-shi, Hiroshima-Ken, Japan, 726-0013
    - Nakahama Heart Clinic
  - Fukuyama-shi, Hiroshima-Ken, Japan, 721-0927
    - Nippon Kokan Fukuyama Hospital
  - Higashihiroshima-shi, Hiroshima-Ken, Japan, 739-0041
    - NHO Higashihiroshima Medical Center
- Hokkaido
  - Sapporo-shi, Hokkaido, Japan, 063-0826
    - Miyanosawa Clinic of Internal Medicine and Cardiology
- Ibaraki-Ken
  - Hitachinaka-shi, Ibaraki-Ken, Japan, 312-0032
    - Tanaka Cardiology Clinic
  - Naka-shi, Ibaraki-Ken, Japan, 311-0113
    - Nakakinen Clinic Medical Corporation Kensei-kai
- Ishikawa-Ken
  - Hakusan-shi, Ishikawa-Ken, Japan, 924-8588
    - Public Central Hospital of Matto Ishikawa
  - Komatsu-shi, Ishikawa-Ken, Japan, 923-8560
    - NHI Komatsu Municipal Hospital
- Iwate-Ken
  - Morioka-shi, Iwate-Ken, Japan, 020-0866
    - Kuonkai Kamata Medical Clinic
  - Morioka-shi, Iwate-Ken, Japan, 020-8505
    - Iwate Medical University Uchimaru Medical Center Hospital
- Kagawa-Ken
  - Takamatsu-shi, Kagawa-Ken, Japan, 760-0076
    - Josuikai Olive Takamatsu Medical Clinic
- Kanagawa-Ken
  - Sagamihara-shi, Kanagawa-Ken, Japan, 252-0311
    - Sohken Yamamoto Clinic
  - Yokohama-shi, Kanagawa-Ken, Japan, 245-8575
    - NHO Yokohama Medical Center
- Kumamoto-Ken
  - Kumamoto-shi, Kumamoto-Ken, Japan, 860-8556
    - Kumamoto University Hospital
  - Tamana-shi, Kumamoto-Ken, Japan, 865-0016
    - Ryubokai Higashi Diabetes and Cardiovascular Clinic
- Kyoto-Fu
  - Kyoto-shi, Kyoto-Fu, Japan, 606-8507
    - Kyoto University Hospital
  - Kyoto-shi, Kyoto-Fu, Japan, 601-1495
    - Ijinkai Takeda General Hospital
  - Kyoto-shi, Kyoto-Fu, Japan, 607-8062
    - Rakuwakai Otowa Hospital
- Miyagi-Ken
  - Osaki-shi, Miyagi-Ken, Japan, 989-6143
    - Sato Hospital
  - Sendai-shi, Miyagi-Ken, Japan, 980-0803
    - Tohoku Kosai Hospital
  - Sendai-shi, Miyagi-Ken, Japan, 980-0873
    - Sendai Kousei Hospital
- Oita-Ken
  - Oita-shi, Oita-Ken, Japan, 870-0192
    - Keiwakai Oita Oka Hospital
- Okayama-Ken
  - Okayama-shi, Okayama-Ken, Japan, 700-8558
    - Okayama University Hospital
- Okinawa-Ken
  - Nakagami-gun, Okinawa-Ken, Japan, 901-2393
    - Okinawa Tokushukai Chubu Tokushukai Hospital
- Osaka-Fu
  - Higashiosaka-shi, Osaka-Fu, Japan, 577-0802
    - Iwasaki Naika Clinic
  - Higashiosaka-shi, Osaka-Fu, Japan, 577-0803
    - Takekawa Naika Clinic
  - Izumisano-shi, Osaka-Fu, Japan, 598-8577
    - Rinku General Medical Center
  - Kashiwara-shi, Osaka-Fu, Japan, 582-0005
    - Shiraiwa Medical Clinic
  - Kishiwada-shi, Osaka-Fu, Japan, 596-8522
    - Tokushukai Kishiwada Tokushukai Hospital
  - Osaka-shi, Osaka-Fu, Japan, 553-0003
    - Kansai Electric Power Hospital
  - Suita-shi, Osaka-Fu, Japan, 564-8565
    - National Cerebral and Cardiovascular Center
  - Toyonaka-shi, Osaka-Fu, Japan, 560-0082
    - Senrichuo Ekimae Clinic
- Saitama-Ken
  - Iruma-gun, Saitama-Ken, Japan, 354-0041
    - IMS Miyoshi General Hospital
  - Kawaguchi-shi, Saitama-Ken, Japan, 332-0012
    - Sugiura Clinic
  - Tokorozawa-shi, Saitama-Ken, Japan, 359-1141
    - Sanyukai Saino Clinic
  - Wako-shi, Saitama-Ken, Japan, 351-0102
    - NHO Saitama National Hospital
- Shiga-Ken
  - Otsu-shi, Shiga-Ken, Japan, 520-2192
    - Shiga University of Medical Science Hospital
- Shimane-Ken
  - Hamada-shi, Shimane-Ken, Japan, 697-8511
    - NHO Hamada Medical Center
- Tochigi-Ken
  - Shimotsuke-shi, Tochigi-Ken, Japan, 329-0498
    - Jichi Medical University Hospital
- Tokyo-To
  - Bunkyo-ku, Tokyo-To, Japan, 113-8431
    - Juntendo University Hospital
  - Chuo-Ku, Tokyo-To, Japan, 103-0027
    - Tokyo-Eki Center-Building Clinic
  - Chuo-ku, Tokyo-To, Japan, 103-0027
    - Fukuwa Clinic
  - Itabashi-ku, Tokyo-To, Japan, 173-0004
    - Nomura Clinic
  - Katsushika-ku, Tokyo-To, Japan, 124-0021
    - Hosoda Clinic
  - Meguro-ku, Tokyo-To, Japan, 153-0053
    - Toyukai Yutenji Medical Clinic (Yutenji Naika)
  - Shinjuku-ku, Tokyo-To, Japan, 169-0073
    - Shinjuku Research Park Clinic
- Yamaguchi-Ken
  - Ube-shi, Yamaguchi-Ken, Japan, 755-8505
    - Yamaguchi University Hospital
Mexico
- - Aguascalientes, Mexico, 20230
    - Centro de Investigacion Cardiometabolica de Aguascalientes S.A de C.V
  - Chihuahua, Mexico, 31237
    - Investigación en Salud y Metabolismo S.C.
  - Veracruz, Mexico, 91900
    - Sociedad de Metabolismo y Corazon S.C
- Baja California Norte
  - Tijuana, Baja California Norte, Mexico, 22500
    - Centro de Investigacion Cardiovascular y Metabólica
- Distrito Federal
  - Mexico, Distrito Federal, Mexico, 14080
    - Instituto Nacional de Ciencias Médicas y Nutricion Dr. Salvador Zubiran
  - Mexico, Distrito Federal, Mexico, 03100
    - Phytomedicamenta S.A. de C.V.
  - Mexico, Distrito Federal, Mexico, 03810
    - Health Pharma Professional Research S.A. de C.V.
  - Mexico, Distrito Federal, Mexico, 06700
    - Centro de Atención e Investigación en Factores de Riesgo Cardiovascular Omega S.C.
  - Mexico, Distrito Federal, Mexico, 67000
    - Mentrials S.A. de C.V.
- Guerrero
  - Acapulco de Juárez, Guerrero, Mexico, 39670
    - Centro de Investigacion Clinica del Pacifico, S.A. de C.V.
- Jalisco
  - Guadalajara, Jalisco, Mexico, 44670
    - Cardiologia Clinica e Intervencionista
  - Zapopan, Jalisco, Mexico, 45116
    - Centro de Investigacion Medica de Occidente, S.C.
- Morelos
  - Cuautla, Morelos, Mexico, 62746
    - Instituto de Diabetes, Obesidad y Nutrición S.C.
- Nuevo León
  - Monterrey, Nuevo León, Mexico, 64460
    - Universidad Autonoma de Nuevo Leon, Hospital Universitario Dr. Jose Eleuterio Gonzalez
  - Monterrey, Nuevo León, Mexico, 64710
    - Centro Medico San Francisco
  - San Nicolas de los Garza, Nuevo León, Mexico, 66465
    - Unidad Médica para la Salud Integral
- Queretaro
  - San Juan del Rio, Queretaro, Mexico, 76800
    - Centro Integral Medico SJR S.C.
- Tamaulipas
  - Madero, Tamaulipas, Mexico, 89440
    - Centro de Estudios de Investigación Metabólicos y Cardiovasculares S.C.
Netherlands
- - Alkmaar, Netherlands, 1815 JD
    - Noordwest Ziekenhuisgroep
  - Almelo, Netherlands, 7609 PP
    - Ziekenhuisgroep Twente, Almelo
  - Amersfoort, Netherlands, 3813 TZ
    - Meander Medisch Centrum
  - Amstelveen, Netherlands, 1186 AM
    - Ziekenhuis Amstelland
  - Amsterdam, Netherlands, 1105 AZ
    - Amsterdam UMC, Locatie AMC
  - Amsterdam, Netherlands, 1034 CS
    - BovenlJ Ziekenhuis
  - Apeldoorn, Netherlands, 7334 DZ
    - Gelre ziekenhuizen, locatie Lukas
  - Arnhem, Netherlands, 6815 AD
    - Rijnstate
  - Den Haag, Netherlands, 2545 AA
    - Haga Ziekenhuis
  - Deventer, Netherlands, 7416 SE
    - Deventer Ziekenhuis
  - Dordrecht, Netherlands, 3318 AT
    - Albert Schweitzer Ziekenhuis, Dordwijk
  - Ede, Netherlands, 6716 RP
    - Gelderse Vallei Ziekenhuis, Ede
  - Eindhoven, Netherlands, 5623 EJ
    - Catharina Ziekenhuis Eindhoven
  - Haarlem, Netherlands, 2035 RC
    - Spaarne Gasthuis, Hoofddorp
  - Heerlen, Netherlands, 6419 PC
    - Zuyderland Medisch Centrum - Heerlen
  - Hoogezand, Netherlands, 9603 AE
    - Huisartsenpraktijk Gorecht
  - Kloosterhaar, Netherlands, 7694 AC
    - Quality Care Research
  - Leiden, Netherlands, 2333 ZA
    - Leids Universitair Medisch Centrum
  - Roosendaal, Netherlands, 4708 AE
    - Bravis Ziekenhuis, Roosendaal
  - Rotterdam, Netherlands, 3083 AN
    - Ikazia Ziekenhuis
  - Rotterdam, Netherlands, 3079 DZ
    - Maasstad Ziekenhuis, Zuider
  - Sliedrecht, Netherlands, 3331 LZ
    - Albert Schweitzer Ziekenhuis, Zwijndrecht
  - Uden, Netherlands, 5406 PT
    - Bernhoven Uden
  - Utrecht, Netherlands, 3508 GA
    - UMC Utrecht
  - Utrecht, Netherlands, 3582 KE
    - Diakonessenhuis, Utrecht
  - Veldhoven, Netherlands, 5504 DB
    - Maxima Medisch Centrum
  - Venlo, Netherlands, 5912 BL
    - VieCuri Medisch Centrum
Poland
- - Bydgoszcz, Poland, 85-231
    - NZOZ Centrum Medyczne KERmed
  - Elblag, Poland, 82-300
    - KARDIOMED Janczska Kociwska Ostki PodckaRekrzSp
  - Gdansk, Poland, 80-952
    - Uniwersyteckie Centrum Kliniczne
  - Gdansk, Poland, 80-286
    - Poradnia Kardiologiczna Jarosław Jurowiecki
  - Gdansk, Poland, 80-382
    - Synexus Polska SCM Sp. z o.o. Gdansku
  - Gdynia, Poland, 81-537
    - Synexus Polska Sp. z o.o. Oddzial w Gdyni
  - Gdynia, Poland, 81-157
    - Indywidualna Specjalistyczna Praktyka Lekarska w Dziedzinie Kardiologii Lek. med. Krzysztof Cymerman
  - Grodzisk Mazowiecki, Poland, 05-825
    - Samodzielny Publiczny Specjalistyczny Szpital Zachodni im. Jana Pawla II
  - Katowice, Poland, 40-040
    - Synexus Polska Sp. Z O.O. Oddzial W Katowicach
  - Katowice, Poland, 40-084
    - Centrum Medyczne Pratia Katowice II
  - Katowice, Poland, 40-635
    - SPSK Nr 7 SUM w Katowicach Gornoslaskie CM im. prof. Leszka Gieca
  - Kielce, Poland, 25-525
    - Specjalistyczna Poradnia Kardiologiczna i Nadcisnienia Tetniczego
  - Krakow, Poland, 31-501
    - Krakowskie Centrum Medyczne Sp. z o.o.
  - Krakow, Poland, 30-363
    - Augustyn Monika
  - Lodz, Poland, 94-255
    - Indywidualna Specjalistyczna Praktyka Lekarska
  - Lodz, Poland, 93-513
    - Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Łodzi
  - Lodz, Poland, 94-048
    - NZOZ ALL-MED Centrum Medyczne Specjalistyczne Gabinety Lekarskie
  - Lublin, Poland, 20-362
    - Ko-med Centra Kliniczne Lublin II
  - Lublin, Poland, 20-709
    - Clinical Best Solutions
  - Lublin, Poland, 20-857
    - NZOZ Twoja Przychodnia
  - Naleczow, Poland, 24-140
    - NZOZ Osrodek Kardiologii Inwazyjnej -Ikardia
  - Oswiecim, Poland, 32-600
    - Medicome Sp. z o.o.
  - Poznan, Poland, 60-702
    - Synexus Polska Sp. z o.o. Oddzial w Poznaniu
  - Poznan, Poland, 61-655
    - Praktyka Lekarska Ewa Krzyzagorska
  - Pulawy, Poland, 24-100
    - KO-MED Centra Kliniczne Pulawy
  - Ruda Slaska, Poland, 41-709
    - NZOZ Przychodnia Specjalistyczna H. Rudzki, A. Wittek
  - Rzeszow, Poland, 35-055
    - Centrum Medyczne Medyk
  - Skierniewice, Poland, 96-100
    - Clinmed Research
  - Sopot, Poland, 81-717
    - NZOZ Pro-Cordis Sopockie Centrum Bad. Kardiolog.
  - Sroda Wielkopolska, Poland, 63-000
    - NSZOZ Medicus
  - Staszow, Poland, 28-200
    - Ko-Med Centra Kliniczne Staszow
  - Szczecin, Poland, 71-531
    - Indywidualna Specjalistyczna Praktyka Lekarska dr n. med. Agnieszka Karczmarczyk Specjalista Chorob
  - Warsaw, Poland, 00-465
    - NBR Polska
  - Warszawa, Poland, 00-631
    - Centrum Medyczne Świat Pacjenta
  - Warszawa, Poland, 01-192
    - Synexus Polska Sp. z o.o. Oddział w Warszawie
  - Wierzchosławice, Poland, 33-122
    - Centrum Zdrowia Tuchow Sp. z o.o.
  - Wroclaw, Poland, 50-381
    - Synexus Polska Sp. z o.o. Oddział we Wroclawiu
  - Zamosc, Poland, 22-400
    - KO-MED Centra Kliniczne Zamosc
Puerto Rico
- - San Juan, Puerto Rico, 00927-5800
    - VA Medical Center - San Juan
Romania
- - Bacau, Romania, 600154
    - S.C. CMI Dr. Pletea Noemi S.R.L
  - Baia Mare, Romania, 430222
    - Cabinet Medical Individual Diabet, Nutritie, Boli Metabolice Dr. Pop Lavinia
  - Brasov, Romania, 500283
    - S.C Centrul Medical de Diagnostic si Tratament Ambulator Neomed S.R.L
  - Bucharest, Romania, 022328
    - Institutul de Urgenta pentru Boli Cardiovasculare "Prof. Dr. C.C. Iliescu"
  - Bucuresti, Romania, 020125
    - Spitalul Clinic Colentina
  - Bucuresti, Romania, 030463
    - S.C Policlinica Ccbr S.R.L
  - Bucuresti, Romania, 010192
    - S.C Clinica Medicala Data Plus S.R.L
  - Bucuresti, Romania, 021659
    - Spitalul Clinic de Urgenta "Sfantul Pantelimon"
  - Bucuresti, Romania, 030088
    - S.C. Health Net S.R.L
  - Bucuresti, Romania, 061072
    - CMI Dr. Stolea T. Violeta - Medic specialist diabet zaharat, nutritie si boli metabolice
  - Buzau, Romania, 120203
    - S.C. Medcon S.R.L.
  - Oradea, Romania, 410159
    - S.C Grandmed S.R.L
  - Oradea, Romania, 410469
    - S.C Pelican Impex S.R.L
  - Pașcani, Romania, 705200
    - S.C. Bella Praxis S.R.L
  - Ploiesti, Romania, 100163
    - S.C. Diabmed Dr. Popescu Alexandrina S.R.L
  - Ploiesti, Romania, 100342
    - CMI Dr Busegeanu Mihaela Magdalena
  - Targu Mures, Romania, 540142
    - S.C Mediab S.R.L
  - Timisoara, Romania, 300359
    - S.C Medicali's S.R.L
  - Timisoara, Romania, 300723
    - Spitalul Clinic Judetean de Urgenta "Pius Brinzeu"
Russian Federation
- - Arkhangelsk, Russian Federation, 163001
    - SBIH of Arkhangelsk region " First City Clinical hospital n.a. E. E. Volosevich"
  - Barnaul, Russian Federation, 656055
    - TSHI "Altay Territorial Cardiologocal dispensary"
  - Ekaterinburg, Russian Federation, 620026
    - SEIHPE "Ural SMA of RosZdrav" b.o. LLC "City Hospital #41"
  - Kemerovo, Russian Federation, 650002
    - FSBI "Scientific-research Institute for Complex Problems of cardiovascular disease"
  - Kemerovo, Russian Federation, 650066
    - SAIH "Kemerovo Regional Clinical Hospital"
  - Kemerovo, Russian Federation, 650000
    - FSHI "MSU of MoIA of RF of Kemerovo Region"
  - Kemerovo, Russian Federation, 650055
    - NSIH "Departmental Hospital on Station Kemerovo of OJSC "Russian Railways"
  - Krasnoyarsk, Russian Federation, 660062
    - TSBIH "Krasnoyarsk Interdistrict Clinical Hospital of Emergency Medical Care n.a. N.S. Karpovich
  - Moscow, Russian Federation, 107 014
    - SBIH of Moscow "City Clinical Hospital n.a.Bakhrushinykh"
  - Moscow, Russian Federation, 117556
    - SBHI "City Polyclinic #2 of Healthcare department of city of Moscow"
  - Moscow, Russian Federation, 117593
    - FSBIH "Central Clinical Hospital of Russian Academy of Sciences"
  - Moscow, Russian Federation, 121359
    - FSBI "Central Clinical Hospital with Polyclinic of the Department for Presidential Affairs of the RF
  - Moscow, Russian Federation, 127473
    - SBEI HPE "Moscow State Medical and Dentistry University n.a. A. I. Evdokimov" of the MoH of the RF
  - Moscow, Russian Federation, 129301
    - SBEI HPE "Moscow State Medical and Dentistry University n.a. A. I. Evdokimov" of the MoH of the RF
  - Murmansk, Russian Federation, 183047
    - Murmansk Regional Clinical Hospital named after Bayandin
  - Novosibirsk, Russian Federation, 630008
    - SBIH of Novosibirsk Region "Clinical Emergency Hospital #2"
  - Novosibirsk, Russian Federation, 630068
    - SBIH of Novosibirsk region "City Clinical Hospital # 19"
  - Novosibirsk, Russian Federation, 630089
    - FSBSI "Scientific Research Institute of Therapy and Preventive Medicine"
  - Novosibirsk, Russian Federation, 630091
    - LLC "RC Medical"
  - Omsk, Russian Federation, 644018
    - BIH of Omsk region "Clinical Medico-Sanitary Unit # 9
  - Omsk, Russian Federation, 644024
    - Llc Ultramed
  - Perm, Russian Federation, 614068
    - SBIH of Perm territory " City Clinical Hospital # 2 n.a. Fedor Khristoforovich Gral"
  - Perm, Russian Federation, 614077
    - State Budgetary Healthcare Institution Clinical Medical Sani
  - Perm, Russian Federation, 614097
    - SHI "Perm Regional Hospital of War Veterans"
  - Rostov-on-Don, Russian Federation, 344068
    - City Emergency Hospital #2
  - Saint-Petersburg, Russian Federation, 197022
    - Pavlov First Saint Petersburg State Medical University
  - Saint-Petersburg, Russian Federation, 190013
    - CJSC Clinic complex
  - Saint-Petersburg, Russian Federation, 194156
    - FSBI North-West Federal Medical Research Center n.a. V.A. Almazov of MoH RF
  - Saint-Petersburg, Russian Federation, 195427
    - Saint-Petersburg SBHI "City outpatient clinic #28"
  - Saint-Petersburg, Russian Federation, 199106
    - SPb SBIH "City Pokrovskaya Hospital"
  - Saint-Petersburg, Russian Federation, 199178
    - LLC Medical Center Mart
  - Saratov, Russian Federation, 410028
    - SIH "Saratov City Clinical Hospital # 2 n.a. V.I. Razumovskiy"
  - Sestroretsk, Russian Federation, 197706
    - SPb SBIH "City Hospital # 40 of Kurortnyi region"
  - St. Petersburg, Russian Federation, 194354
    - SPb SBIH "City Multy-field Hospital # 2"
  - St. Petersburg, Russian Federation, 196084
    - LLC "Institute of Medical Examinations"
  - St. Petersburg, Russian Federation, 197136
    - Llc "Medinet"
  - St. Petersburg, Russian Federation, 198510
    - SPb SBIH "Nikolaevskaya Hospital"
  - Tomsk, Russian Federation, 634012
    - FSBI "Research Institute for Cardiology" of Siberian Branch RAMS
  - Tver, Russian Federation, 170036
    - SHI "Regional Clinical Hospital"
  - Ulyanovsk, Russian Federation, 432063
    - SHI Ulyanovsk Reg Clinical Hospital
  - Yaroslavl, Russian Federation, 150047
    - Yaroslavl Regional Clinical Hospital of War Veterans
Slovakia
- - Bardejov, Slovakia, 085 01
    - Alian s.r.o.
  - Bardejov, Slovakia, 08501
    - Thyreomedical s.r.o.
  - Bratislava, Slovakia, 81108
    - Metabol KLINIK s.r.o.
  - Bratislava, Slovakia, 821 07
    - Galenum, s.r.o.
  - Bratislava, Slovakia, 82102
    - DIAFA s.r.o.
  - Bratislava, Slovakia, 82108
    - Diabet, spol. s.r.o.
  - Bratislava, Slovakia, 83101
    - Kardiovaskularne centrum, s.r.o.
  - Bratislava, Slovakia, 84108
    - Kardiologicka, interna a sonograficka amb. Kardio-Sanus, sro
  - Bratislava, Slovakia, 85101
    - MEDISPEKTRUM PLUS s.r.o.
  - Bratislava, Slovakia, 85101
    - MUDr. Vladimir Gergel, s.r.o.
  - Dolny Kubin, Slovakia, 02601
    - ENDIAMED, s.r.o.
  - Komarno, Slovakia, 94501
    - MEDICUS plus s.r.o.
  - Kosice, Slovakia, 04001
    - Human-Care s.r.o.
  - Kosice, Slovakia, 04001
    - Sukromna interna a kardiologicka ambulancia
  - Levice, Slovakia, 93401
    - DIA- Kontrol s.r.o.
  - Levice, Slovakia, 93405
    - CELL B, s.r.o.
  - Lucenec, Slovakia, 984 39
    - Kardio 1 S.R.O.
  - Lucenec, Slovakia, 98401
    - IN-DIA s.r.o.
  - Nitra, Slovakia, 94911
    - MUDr. Zuzana Ochodnicka,
  - Nove Zamky, Slovakia, 94002
    - Fakultna nemocnica s poliklinikou Nove Zamky
  - Presov, Slovakia, 08001
    - DIABETOL s.r.o.
  - Presov, Slovakia, 08001
    - MEDISPOL s.r.o.
  - Roznava, Slovakia, 04801
    - Nemocnica s poliklinikou sv. Barbory Roznava a.s.
  - Sahy, Slovakia, 93601
    - Peter Farkas MD, s.r.o.
  - Svidnik, Slovakia, 08901
    - Interna SK s.r.o.
  - Svidnik, Slovakia, 08901
    - Nemocnica arm. generala L. Svobodu Svidnik, a.s.,
  - Trencin, Slovakia, 91101
    - Diabetes centrum, s.r.o.
  - Trnava, Slovakia, 91701
    - JAL s.r.o.
  - Zilina, Slovakia, 01001
    - Medivasa s.r.o.
South Africa
- Gauteng
  - Alberton, Gauteng, South Africa, 1449
    - Cardiology Clinical Research
  - Centurion, Gauteng, South Africa, 0157
    - Johese Clinical Research: Unitas
  - Johannesburg, Gauteng, South Africa, 2013
    - Wits Clinical Research
  - Johannesburg, Gauteng, South Africa, 1827
    - Lenasia Clinical Trial Centre
  - Johannesburg, Gauteng, South Africa, 1724
    - Medicross Roodepoort Clinical Research
  - Kempton Park, Gauteng, South Africa, 1619
    - Clinresco Centres (Pty) Ltd
  - Mamelodi East, Gauteng, South Africa, 0122
    - Synexus SA - Stanza Clinical Research Centre
  - Pretoria, Gauteng, South Africa, 0084
    - Emmed Research
  - Pretoria, Gauteng, South Africa, 0002
    - Seeber, M
  - Pretoria, Gauteng, South Africa, 0184
    - Synexus SA Watermeyer Clinical Research Centre
  - Pretoria, Gauteng, South Africa, 1692
    - Johese Clinical Research: Midstream
- Limpopo
  - Thabazimbi, Limpopo, South Africa, 0380
    - Limpopo Clinical Research Initiative
- Mpumalanga
  - Moloto, Mpumalanga, South Africa, 1022
    - Dr AA Mahomed Medical Centre
- Western Cape
  - Cape Town, Western Cape, South Africa, 7530
    - Tiervlei Trial Centre
  - Cape Town, Western Cape, South Africa, 7130
    - Synexus Helderberg Clinical Research Centre
  - Cape Town, Western Cape, South Africa, 7500
    - Corbod Research
  - Cape Town, Western Cape, South Africa, 7500
    - TREAD Research
  - Cape Town, Western Cape, South Africa, 7580
    - Cape Town Medical Research Centre
  - Cape Town, Western Cape, South Africa, 7646
    - Paarl Research Centre
  - Cape Town, Western Cape, South Africa, 7925
    - Groote Schuur Hospital Lipid Laboratory
  - Somerset West, Western Cape, South Africa, 7130
    - Dr JM Engelbrecht Practice
  - Somerset West, Western Cape, South Africa, 7130
    - Helderberg Research Institute
Spain
- - Almeria, Spain, 04120
    - Hospital Virgen del Mar
  - Barcelona, Spain, 08003
    - Hospital Del Mar
  - Barcelona, Spain, 08025
    - Hospital de la Santa Creu i Sant Pau
  - Barcelona, Spain, 08035
    - Hospital Universitari Vall d'Hebron
  - Barcelona, Spain, 08023
    - Hospital Quirónsalud Barcelona
  - Madrid, Spain, 28034
    - Hospital Universitario Ramón y Cajal
  - Málaga, Spain, 29010
    - Hospital Regional Universitario de Málaga
  - Sevilla, Spain, 41071
    - Hospital Universitario Virgen Macarena
  - Sevilla, Spain, 41010
    - Hospital Quironsalud Infanta Luisa
  - Sevilla, Spain, 41003
    - Nuevas tecnologías en Diabetes y Endocrinología
- Barcelona
  - Badalona, Barcelona, Spain, 08916
    - Hospital Universitari Germans Trias I Pujol
- Cádiz
  - Sanlucar de Barrameda, Cádiz, Spain, 11540
    - Hospital Virgen del Camino
- Córdoba
  - Cordoba, Córdoba, Spain, 14004
    - Hospital Universitario Reina Sofia
- La Coruña
  - A Coruña, La Coruña, Spain, 15006
    - Complejo Hospitalario Universitario A Coruna
  - Santiago de Compostela, La Coruña, Spain, 15706
    - Complejo Hospitalario Universitario de Santiago
Ukraine
- - Cherkasy, Ukraine, 18009
    - Cherkasy Regional Cardiological Center
  - Cherkasy, Ukraine, 18009
    - CI Cherkasy RH of Cherkasy Regional Council
  - Chernivtsi, Ukraine, 58000
    - CMI CCH#3 Dep of Ther# w the beds of card profile HSEI of UBSMU
  - Chernivtsi, Ukraine, 58022
    - RCI Chernivtsi Regional Endocrinology Center Policlinic Dept SHEI of UBSMU
  - Dnipro, Ukraine, 49038
    - Medical Center of Limited Liability Company Medical Center Clinic of Family Medicine
  - Dnipro, Ukraine, 49000
    - CI Dnipropetrovsk City Cl Hosp #9 of Dniprop Reg Council SI DMA of MOH of Ukr Ch of Endocrinology
  - Ivano-Frankivsk, Ukraine, 76008
    - Regional CH Dept of Endocrinology SHEI Ivano-Frankivsk NMU
  - Ivano-Frankivsk, Ukraine, 76018
    - CI Ivano-Frankivsk Reg Cl Card Center Dept of Chronic Ischemic Heart Dis SHEI Ivano-Frank NMU
  - Ivano-Frankivsk, Ukraine, 76018
    - Ivano-Frankivsk CCH Dept of Therapy #1 SHEI Ivano-Frankivsk NMU
  - Kharkiv, Ukraine, 61039
    - GI L.T.Malaya Therapy National Institute of the NAMS of Ukraine
  - Kharkiv, Ukraine, 61103
    - Railway Transport Kharkiv CH#1 of Healthcare Center Branch of PJSC Ukrainian Railway
  - Kharkiv, Ukraine, 61002
    - CHI Kharkiv City Student Hosp Therap dept Nat Pharm Univer
  - Kharkiv, Ukraine, 61037
    - CNE Prof. O.O. Shalimov Kharkiv City Clinical Hospital #2 KCC
  - Kharkiv, Ukraine, 61039
    - State Institution LT Malaya Inst. of Ther. of AMS of Ukraine
  - Kharkiv, Ukraine, 61103
    - Railway Transport Kharkiv CH #1 of Healthcare Center Branch of PJSC Ukr Railway
  - Kharkiv, Ukraine, 61106
    - MC Doctor Alex Dept of General Practice-Family Medicine Kharkiv MA of PGE
  - Kharkiv, Ukraine, 61176
    - CNE City Clin Hosp #8 of KCC Dept of Therapy Kharkiv MA of PGE of MOHU
  - Kherson, Ukraine, 73000
    - CI Ye.Ye.Karabelesh Kherson City Clinical Hosp.
  - Kyiv, Ukraine, 03049
    - Kyiv CH on Railway Transport #2 of Branch Center of Healthcare Public Company Ukr Railway
  - Kyiv, Ukraine, 03680
    - SI NSC M.D. Strazhesko Institute of Cardiology of NAMSU
  - Kyiv, Ukraine, 01103
    - Kyiv CCH #12 Dept of Therapy O.O.Bogomolets NMU
  - Kyiv, Ukraine, 04050
    - Medical Center of Limited Liability Company Medical Center Concilium Medical
  - Kyiv, Ukraine, 02002
    - LLC Treatment and Diagnostic Center Adonis Plus
  - Kyiv, Ukraine, 01004
    - KCCC of Endocr Dept of General Endocrine Pathology O. O. Bogomolets NMU
  - Kyiv, Ukraine, 02002
    - MC of PHEI Institute of General Practice - Family Medicine
  - Kyiv, Ukraine, 02081
    - Medical Center Blagomed Plus LLC
  - Kyiv, Ukraine, 02091
    - Med Center 'Ok!Clinic+' of International Institute of Clinical Trials LLC
  - Kyiv, Ukraine, 03037
    - MC of Subsidiary Production Unit Med Scient Pract Union Medbud of PJSc Holding Company Kyivmiskbud
  - Kyiv, Ukraine, 03110
    - Med Center of Eurolab LLC Policlinic Outpatient Dept O.O.Bogomolets NMU
  - Kyiv, Ukraine, 03115
    - SI National Scientific Centre of Radiation Medicine of NAMSU
  - Kyiv, Ukraine, 03680
    - SI NSС M.D. Strazhesko Institute of Cardiology of NAMSU
  - Kyiv, Ukraine, 04050
    - Department of Medical Services and Rehabilitation of State Joint Stock Holding Company Artem
  - Kyiv, Ukraine, 04053
    - CI of Kyiv RC Regional Clinical Hospital #2
  - Kyiv, Ukraine, 04114
    - SI V.P.Komisarenko Institute of E&M of NAMSU
  - Kyiv, Ukraine, 04114
    - SI V.P.Komisarenko Institute of Endocrinology and Metabolism of NAMSU
  - Lviv, Ukraine, 79010
    - Lviv Reg St Clin Treatment - Diagnostic Endocrin Center, Dept of Polyclinic, D.Galytskyy Lviv NMU
  - Lviv, Ukraine, 79011
    - Lviv Communal 4th City Clinical Hospital
  - Odesa, Ukraine, 65000
    - Center of Reconstructive & Restorative Medicine (University Clinic) of Odessa National Medical Uni
  - Sumy, Ukraine, 40021
    - CI Sumy City Clinical Hospital #1 Dept of Therapy Sumy SU Med Inst
  - Ternopil, Ukraine, 46023
    - Ternopil City Municipal Hospital #2 Dept of Gastroenterology Ternopil I.Ya. Gorbachevskyi SMU
  - Uzhgorod, Ukraine, 88014
    - Transcarpathian Regional Clinical Cardiology Dispansery
  - Vinnytsia, Ukraine, 21018
    - National Pirogov Memorial Medical University
  - Vinnytsia, Ukraine, 21029
    - SRI of Invalid Rehabilitation (EST Complex) of Vinnytsia M.I.Pyrogov NMU MOHU
  - Vinnytsia, Ukraine, 21001
    - Private Small Enterprise Medical Center Pulse
  - Vinnytsia, Ukraine, 21010
    - Vinnytsia RC Highly Special.Endocr.Center Dept of Therapy #2 M.I. Pyrogov NMU
  - Zaporizhzhia, Ukraine, 69001
    - CI Zapor CCH#10 SI ZMA PGE Ch of therapy clin pharmacol & endocrin
  - Zhytomyr, Ukraine, 10002
    - Zhytomyr regional clinical hospital n.a. O.F. Gerbachevskyy
  - Zhytomyr, Ukraine, 10002
    - CI Central City Hospital #1 of Zhytomyr
United Kingdom
- - Swansea, United Kingdom, SA6 6NL
    - Morriston Hospital
- Berkshire
  - Reading, Berkshire, United Kingdom, RG2 0TG
    - Synexus Thames
- Cornwall
  - Hayle, Cornwall, United Kingdom, TR27 5DT
    - Mounts Bay Medical Ltd
  - Liskeard, Cornwall, United Kingdom, PL14 3XA
    - Oak Tree Surgery
  - Penzance, Cornwall, United Kingdom, TR18 4JH
    - The Alverton Practice
  - Torpoint, Cornwall, United Kingdom, PL11 2TB
    - Rame Medical Limited
- Devon
  - Plymouth, Devon, United Kingdom, PL5 3JB
    - Knowle House Surgery
  - Torquay, Devon, United Kingdom, TQ2 7AA
    - Torbay Hospital
- Durham
  - Stockton on Tees, Durham, United Kingdom, TS19 8PE
    - Synexus Clinical Research North Tees
- Essex
  - Chelmsford, Essex, United Kingdom, CM1 7ET
    - Broomfield Hospital
- Greater London
  - London, Greater London, United Kingdom, EC1A 7BE
    - Barts Hospital
- Greater Manchester
  - Manchester, Greater Manchester, United Kingdom, M13 9WL
    - Manchester Royal Infirmary
  - Manchester, Greater Manchester, United Kingdom, M15 6SX
    - Synexus Manchester Clinical Research Centre
- Lancashire
  - Blackpool, Lancashire, United Kingdom, FY4 3AD
    - Waterloo Medical Centre
  - Chorley, Lancashire, United Kingdom, PR7 7NA
    - Synexus Lancashire Clinical Research Centre
- Merseyside
  - Liverpool, Merseyside, United Kingdom, L22 0LG
    - Synexus Merseyside Clinical Research Centre
- Northumberland
  - Hexham, Northumberland, United Kingdom, NE46 1QJ
    - Synexus Hexham General Hospital
- South Glamorgan
  - Cardiff, South Glamorgan, United Kingdom, CF15 9SS
    - Synexus Wales Clinical Research Centre
- Strathclyde
  - Glasgow, Strathclyde, United Kingdom, G20 OSP
    - Synexus Scotland Clinical Research Centre
- Tayside Region
  - Dundee, Tayside Region, United Kingdom, DD1 9SY
    - Ninewells Hospital
- West Midlands
  - Birmingham, West Midlands, United Kingdom, B15 2SQ
    - Synexus Birmingham Clinical Research Centre
United States
- Alabama
  - Birmingham, Alabama, United States, 35233
    - University of Alabama at Birmingham
  - Birmingham, Alabama, United States, 35235
    - Alabama Clinical Therapeutics, LLC
  - Birmingham, Alabama, United States, 35211
    - Synexus Clinical Research US, Inc.
  - Birmingham, Alabama, United States, 35233
    - VA Medical Center - Birmingham
  - Gulf Shores, Alabama, United States, 36542
    - Fundamental Research, LLC
  - Mobile, Alabama, United States, 36608
    - Mobile Heart Specialists, PC
  - Tuscumbia, Alabama, United States, 35674
    - Terence T. Hart, MD
- Arizona
  - Chandler, Arizona, United States, 85224-6279
    - Synexus Clinical Research US, Inc.
  - Mesa, Arizona, United States, 85206
    - Synexus Clinical Research US, Inc.
  - Peoria, Arizona, United States, 85381
    - Arizona Arthritis & Rheumatology Research, PLLC
  - Phoenix, Arizona, United States, 85012
    - Phoenix Veterans Adminstration Health Care System
  - Phoenix, Arizona, United States, 85050
    - Synexus Clinical Research US, Inc.
  - Surprise, Arizona, United States, 85374
    - Clinical Research Institute of Arizona, LLC
  - Tucson, Arizona, United States, 85745
    - Eclipse Clinical Research
  - Tucson, Arizona, United States, 85712
    - Synexus Clinical Research US, Inc.
- Arkansas
  - Little Rock, Arkansas, United States, 72205
    - Central Arkansas Veterans Healthcare System
- California
  - Alhambra, California, United States, 91801
    - Clinical Research Alliance, Inc
  - Costa Mesa, California, United States, 92627
    - Aurora Care Clinic
  - Escondido, California, United States, 92025
    - AMCR Institute, Inc.
  - Huntington Beach, California, United States, 92648-1717
    - National Institute of Clinical Research
  - Loma Linda, California, United States, 92354
    - VA Loma Linda Healthcare System
  - Long Beach, California, United States, 90822
    - VA Long Beach Healthcare System
  - Los Angeles, California, United States, 90073
    - VA Greater Los Angeles Healthcare System
  - Los Angeles, California, United States, 90022
    - Eastside Clinical Research Associates
  - Los Gatos, California, United States, 95032
    - Richard S. Cherlin, MD
  - Northridge, California, United States, 91324
    - Northridge Clinical Research Inc.
  - Palo Alto, California, United States, 94304
    - Palo Alto Division
  - Pasadena, California, United States, 91105
    - Huntington Hospital - Research Department
  - Rancho Cucamonga, California, United States, 91730
    - Rancho Cucamonga Clinical Research
  - San Diego, California, United States, 92119
    - MD Strategies Research Centers
  - Santa Maria, California, United States, 93454
    - Alex Harrison, MD Inc.
  - Santa Rosa, California, United States, 95404
    - Santa Rosa Cardiology Medical Group, Inc.
  - Vista, California, United States, 92083
    - Blue Coast Cardiology
- Colorado
  - Aurora, Colorado, United States, 80012
    - Lynn Institute of Denver
  - Golden, Colorado, United States, 80401
    - New West Physicians, PC
  - Littleton, Colorado, United States, 80127
    - Southwest Family Medicine
- Connecticut
  - Waterbury, Connecticut, United States, 06708
    - Chase Medical Research, LLC
  - West Haven, Connecticut, United States, 06516-2770
    - VA Connecticut Healthcare Sys
- Delaware
  - Newark, Delaware, United States, 19713
    - Cardiology Physicians, PA
- Florida
  - Bay Pines, Florida, United States, 33744
    - Bay Pines VA Healthcare System
  - Bradenton, Florida, United States, 34201
    - Meridien Research
  - Brandon, Florida, United States, 33511
    - Clinical Research of Brandon, LLC
  - Clearwater, Florida, United States, 33756
    - Clearwater Cardiovascular Consultants
  - Daytona Beach, Florida, United States, 32114
    - Daytona Heart Group
  - Delray Beach, Florida, United States, 33446
    - Cohen Medical Research Associates, LLC
  - Gainesville, Florida, United States, 32608
    - Malcom Randall VA Medical Center
  - Hollywood, Florida, United States, 33024
    - Pines Clinical Research, Inc.
  - Homestead, Florida, United States, 33030
    - Homestead Cardiac & Vein Center
  - Jacksonville, Florida, United States, 32205
    - Westside Center for Clinical Research
  - Jacksonville, Florida, United States, 32216
    - Jacksonville Center for Clinical Research
  - Jupiter, Florida, United States, 33458
    - Health Awareness, Inc.
  - Lakeland, Florida, United States, 33805
    - Meridien Research
  - Largo, Florida, United States, 33777
    - Clearwater Cardiovascular & Interventional Consultants
  - Miami, Florida, United States, 33136
    - University of Miami
  - Miami, Florida, United States, 33174
    - Advanced Medical Research Institute
  - Ocala, Florida, United States, 34471
    - Ocala Research Institute, Inc.
  - Ocala, Florida, United States, 34474
    - Morgan Medical Management & Consultants Inc.
  - Ocoee, Florida, United States, 34761
    - Endocrine Associates of Florida
  - Orlando, Florida, United States, 32803
    - Research Physicians Network Alliance
  - Pembroke Pines, Florida, United States, 33029
    - DBC Research, Corp
  - Pembroke Pines, Florida, United States, 33026
    - Andres Patron, D.O., P.A
  - Pensacola, Florida, United States, 32501
    - Langhorne Cardiology Consultants, Inc.
  - Safety Harbor, Florida, United States, 34695
    - Clearwater Cardiovascular Consultants
  - Saint Petersburg, Florida, United States, 33713
    - Professional Health Care of Pinellas
  - Tampa, Florida, United States, 33612
    - James A. Haley VA Medical Center
  - Winter Haven, Florida, United States, 33880
    - Clinical Research of Central Florida
- Georgia
  - Atlanta, Georgia, United States, 30322
    - Emory University
  - Cumming, Georgia, United States, 30041
    - Atlanta Heart Specialists, LLC
  - Decatur, Georgia, United States, 30033
    - VA Medical Center - Atlanta
  - Dunwoody, Georgia, United States, 30338
    - Alta Pharmaceutical Research Center, Inc.
  - Tucker, Georgia, United States, 30084
    - Atlanta Heart Specialists, LLC
- Illinois
  - Champaign, Illinois, United States, 61822
    - Christie Clinic, LLC
  - Chicago, Illinois, United States, 60607
    - Apex Medical Research, AMR, Inc.
  - Gurnee, Illinois, United States, 60031
    - Clinical Investigation Specialists, Inc.
  - Hines, Illinois, United States, 60141
    - Edward Hines Jr. VA Hospital
  - Normal, Illinois, United States, 61761
    - Advocate Health and Hospitals Corp
  - North Chicago, Illinois, United States, 60064
    - Captain James A. Lovell Federal Health Care Center
  - Olympia Fields, Illinois, United States, 60461
    - Specialty Physicians of Illinois
- Indiana
  - Anderson, Indiana, United States, 46011
    - Community Hospital of Anderson and Madison County, Inc.
  - Evansville, Indiana, United States, 47714
    - Synexus Clinical Research US, Inc.
  - Evansville, Indiana, United States, 47725
    - Deaconess Clinic
  - Indianapolis, Indiana, United States, 46202
    - VA Medical Center - Indianapolis
  - Munster, Indiana, United States, 46321
    - Cardiovascular Research of Northwest Indiana, LLC
  - Valparaiso, Indiana, United States, 46383
    - Buynak Clinical Research
- Iowa
  - Council Bluffs, Iowa, United States, 51501
    - West Broadway Clinic
  - Des Moines, Iowa, United States, 50314
    - Iowa Diabetes and Endocrinology Research Center, PLC
  - West Des Moines, Iowa, United States, 50266
    - The Iowa Clinic, PC
- Kansas
  - Kansas City, Kansas, United States, 66160
    - University of Kansas Medical Center Research Institute, Inc.
  - Leavenworth, Kansas, United States, 66048
    - VA Eastern Kansas Health Care
- Kentucky
  - Lexington, Kentucky, United States, 40503
    - The Research Group of Lexington, LLC
  - Louisville, Kentucky, United States, 40206
    - Robley Rex VA Medical Center
- Louisiana
  - Alexandria, Louisiana, United States, 71301
    - Cambridge Medical Trials
  - Covington, Louisiana, United States, 70433
    - Cardiovascular Associates Research, LLC
  - Lake Charles, Louisiana, United States, 70601
    - Centex Studies Inc.
  - Shreveport, Louisiana, United States, 71101
    - Overton Brooks VA Medical Center
- Maine
  - Biddeford, Maine, United States, 04005
    - Southern Maine Health Care
- Maryland
  - Baltimore, Maryland, United States, 21201
    - University of Maryland School of Medicine
  - Baltimore, Maryland, United States, 21229
    - Maryland Cardiovascular Specialists
  - Baltimore, Maryland, United States, 21201
    - Baltimore VA medical centre
  - Hyattsville, Maryland, United States, 20782
    - MedStar Health Research Institute
  - Salisbury, Maryland, United States, 21804
    - Delmarva Heart Research Foundation, Inc.
- Massachusetts
  - Boston, Massachusetts, United States, 02215
    - Joslin Diabetes Center
  - Haverhill, Massachusetts, United States, 01830
    - Pentucket Medical Associates
  - Milton, Massachusetts, United States, 02186
    - South Shore Internal Medicine Associates
- Michigan
  - Ann Arbor, Michigan, United States, 48105
    - University of Michigan
  - Ann Arbor, Michigan, United States, 48105
    - Veterans Affairs Ann Arbor Healthcare System
  - Buckley, Michigan, United States, 49620
    - Northern Pines Health Center
  - Cadillac, Michigan, United States, 49601
    - Cadillac Clinical Research, LLC
  - Flint, Michigan, United States, 48504
    - AA MRC LLC Ahmed Arif Medical Research Center
  - Lansing, Michigan, United States, 48912
    - Sparrow Clinical Research Institute
  - Saginaw, Michigan, United States, 48602
    - Covenant Medical Center, INC.
- Minnesota
  - Minneapolis, Minnesota, United States, 55407
    - Minneapolis Heart Institute Foundation
  - Richfield, Minnesota, United States, 55432
    - Synexus Clinical Research US, Inc.
  - Saint Cloud, Minnesota, United States, 56303-1900
    - CentraCare Heart & Vascular
  - Saint Paul, Minnesota, United States, 55102
    - HealthEast Medical Research Institute
- Mississippi
  - Jackson, Mississippi, United States, 39216
    - GV Montgomery VA Medical Center
- Missouri
  - Kansas City, Missouri, United States, 64128
    - Kansas City VA Medical Center
  - Saint Louis, Missouri, United States, 63141
    - Synexus Clinical Research US, Inc.
- Montana
  - Kalispell, Montana, United States, 59901
    - Kalispell Regional Medical Center dba Glacier View Research Institute
- Nebraska
  - Omaha, Nebraska, United States, 68198-4120
    - University of Nebraska Medical Center
  - Omaha, Nebraska, United States, 68105
    - VA Nebraska-Western Iowa Health Care System
  - Papillion, Nebraska, United States, 68046
    - Synexus Clinical Research US, Inc.
- Nevada
  - Henderson, Nevada, United States, 89052
    - Synexus Clinical Research US, Inc.
  - Las Vegas, Nevada, United States, 89146
    - Red Rock Clinical Research LLC
  - Reno, Nevada, United States, 89502
    - VA Sierra Nevada Health Care System
- New Hampshire
  - Nashua, New Hampshire, United States, 03063
    - Southern New Hampshire Diabetes and Endocrinology
- New Jersey
  - Eatontown, New Jersey, United States, 07724
    - Monmouth Cardiology Associates
  - Linden, New Jersey, United States, 07036
    - NJ Heart
  - Ridgewood, New Jersey, United States, 07450
    - The Valley Hospital
- New Mexico
  - Albuquerque, New Mexico, United States, 87108
    - Raymond G. Murphy VA Medical Center
- New York
  - Albany, New York, United States, 12206
    - Endocrine Group, L.L.P.
  - Albany, New York, United States, 12208
    - Stratton Veterans Affairs Medical Center - Albany
  - Buffalo, New York, United States, 14215
    - Buffalo VA Medical Center
  - Mineola, New York, United States, 11501
    - Winthrop Cardiology Associates
  - New York, New York, United States, 10029
    - Icahn School of Medicine at Mount Sinai
  - Syracuse, New York, United States, 13210
    - SUNY Upstate Medical University
  - Syracuse, New York, United States, 13210
    - VA Medical Center - Syracuse
- North Carolina
  - Asheboro, North Carolina, United States, 27203
    - Randolph Medical Associates
  - Asheville, North Carolina, United States, 28801
    - OnSite Clinical Solutions, LLC
  - Burlington, North Carolina, United States, 27215
    - Kernodle Clinic, Inc., Dept. of the Private Diagnostic Clinic, PLLC
  - Cary, North Carolina, United States, 27518
    - PMG Research of Cary, LLC
  - Cary, North Carolina, United States, 27518
    - Cary Research Group, LLC
  - Charlotte, North Carolina, United States, 28204
    - Novant Health - Heart and Vascular Institute
  - Charlotte, North Carolina, United States, 28204
    - The Presbyterian Hospital
  - Charlotte, North Carolina, United States, 28277
    - Focus Clinical Research Solutions
  - Greensboro, North Carolina, United States, 27408
    - Medication Management, LLC
  - Greensboro, North Carolina, United States, 27410
    - Triad Clinical Trials, LLC
  - Hickory, North Carolina, United States, 28601
    - PMG Research of Hickory, LLC
  - Hickory, North Carolina, United States, 28601
    - Clinical Trials of America-NC, LLC
  - Mooresville, North Carolina, United States, 28117
    - Research Institute of the Carolinas, PLC
  - Morehead City, North Carolina, United States, 28557
    - Diabetes and Endocrinology Consultants
  - Pinehurst, North Carolina, United States, 28374
    - Pinehurst Medical Clinic Inc
  - Raleigh, North Carolina, United States, 27609
    - PMG Research of Raleigh, LLC
  - Rocky Mount, North Carolina, United States, 27804
    - PMG Research of Rocky Mount, LLC
  - Salisbury, North Carolina, United States, 28144
    - PMG Research of Salisbury, LLC
  - Shelby, North Carolina, United States, 28150-3803
    - Carolina Research Center, Inc.
- Ohio
  - Akron, Ohio, United States, 44311
    - Synexus Clinical Research US, Inc.
  - Athens, Ohio, United States, 45701
    - OhioHealth Heart & Vascular Physicians (Heartcare, Inc.) - Athens
  - Canton, Ohio, United States, 44710
    - Aultman Hospital
  - Cincinnati, Ohio, United States, 45215
    - Hometown Urgent Care & Occupational Health
  - Cincinnati, Ohio, United States, 45267
    - Cincinnati Veterans Affairs Medical Center
  - Cleveland, Ohio, United States, 44106
    - Louis Stokes Cleveland Dept of VA Medical Center
  - Franklin, Ohio, United States, 45005
    - Prestige Clinical Research Center
  - Marion, Ohio, United States, 43302
    - Craig S Thompson MD LLC
- Oklahoma
  - Norman, Oklahoma, United States, 73069
    - Lynn Institute of Norman
  - Norman, Oklahoma, United States, 73069
    - Intend Research
  - Oklahoma City, Oklahoma, United States, 73104
    - Oklahoma City Clinic - Central
  - Oklahoma City, Oklahoma, United States, 73135
    - South Oklahoma Heart Research Group
- Oregon
  - Medford, Oregon, United States, 97504
    - Heart Clinic of Southern Oregon
- Pennsylvania
  - Chambersburg, Pennsylvania, United States, 17201
    - Chambersburg Hospital
  - Feasterville, Pennsylvania, United States, 19053
    - AMH Feasterville Family Health Care Center
  - Levittown, Pennsylvania, United States, 19056
    - Family Medical Associates
  - Pittsburgh, Pennsylvania, United States, 15240
    - VA Pittsburgh Healthcare System
  - Pittsburgh, Pennsylvania, United States, 15317
    - Preferred Primary Care Physicians
  - Scottdale, Pennsylvania, United States, 15683
    - Fay West Family Practice
  - Smithfield, Pennsylvania, United States, 15478
    - Montgomery Medical Inc.
- Rhode Island
  - Cumberland, Rhode Island, United States, 02864
    - Partners in Clinical Research
  - Lincoln, Rhode Island, United States, 02865
    - Ocean State Clinical Research Partners
  - Providence, Rhode Island, United States, 02908
    - Providence Veteran Administration Medical Center
- South Carolina
  - Anderson, South Carolina, United States, 29621-2062
    - Synexus Clinical Research US, Inc.
  - Charleston, South Carolina, United States, 29401
    - Ralph H. Johnson VA Medical Center
  - Greer, South Carolina, United States, 29651
    - Mountain View Clinical Research, Inc.
  - Indian Land, South Carolina, United States, 29707
    - Piedmont Research Partners
  - Little River, South Carolina, United States, 29566
    - Main Street Physician's Care - Waterway
  - Myrtle Beach, South Carolina, United States, 29588
    - Family Medicine of Sayebrook
  - Spartanburg, South Carolina, United States, 29302
    - Palmetto Research Center, LLC
  - Summerville, South Carolina, United States, 29485
    - Palmetto Clinical Research
- Tennessee
  - Bristol, Tennessee, United States, 37620
    - PMG Research of Bristol, LLC
  - Chattanooga, Tennessee, United States, 37421
    - WR-ClinSearch, LLC
  - Chattanooga, Tennessee, United States, 37404
    - Chattanooga Medical Research, Llc
  - Chattanooga, Tennessee, United States, 37411
    - University Diabetes & Endocrine Consultants
  - Chattanooga, Tennessee, United States, 37404
    - Chattanooga Research and Medicine (CHARM)
  - Kingsport, Tennessee, United States, 37660
    - Holston Medical Group, P.C.
  - Knoxville, Tennessee, United States, 37934
    - Metro Knoxville HMA, LLC
  - Memphis, Tennessee, United States, 38104
    - VA Medical Center - Memphis
  - Nashville, Tennessee, United States, 37232
    - Tennessee Valley Healthcare System
- Texas
  - Austin, Texas, United States, 78705
    - Central Texas Clinical Research, LLC
  - Dallas, Texas, United States, 75234
    - Synexus Clinical Research US, Inc.
  - Dallas, Texas, United States, 75231
    - North Texas Endocrine Center
  - Dallas, Texas, United States, 75208
    - Protenium Clinical Research
  - Dallas, Texas, United States, 75216
    - VA Medical Center - Dallas
  - Dallas, Texas, United States, 75231
    - Research Institute of Dallas, P.A.
  - Edinburg, Texas, United States, 78539
    - Doctors Hospital at Renaissance
  - Fort Worth, Texas, United States, 76132
    - Diabetes and Thyroid Center of Fort Worth
  - Fort Worth, Texas, United States, 76104
    - Texas Health Research & Education Institute
  - Fort Worth, Texas, United States, 76107
    - University of North Texas Health Science Center
  - Fort Worth, Texas, United States, 76164
    - Rockwood Medical Clinic
  - Fort Worth, Texas, United States, 76107
    - Texas Health Physicians Group
  - Houston, Texas, United States, 77030
    - Michael E. DeBakey VA Medical Center
  - Houston, Texas, United States, 77008
    - Heights Doctors Clinic
  - Houston, Texas, United States, 77081
    - Southwest Clinical Trials
  - Houston, Texas, United States, 77002
    - East Texas Cardiology PA
  - Houston, Texas, United States, 77004
    - Endocrine Associates, LLC
  - Houston, Texas, United States, 77027
    - Associates in Medicine
  - Hurst, Texas, United States, 76054
    - Protenium Clinical Research
  - Pearland, Texas, United States, 77584
    - Houston Methodist Research Institute - CCAT Pearland
  - Plano, Texas, United States, 75075
    - Clinical Investigations of Texas
  - San Antonio, Texas, United States, 78205
    - Consano Clinical Research, LLC
  - San Antonio, Texas, United States, 78220
    - Sant Antonio Premiere Internal Medicine
  - San Antonio, Texas, United States, 78224
    - Briggs Clinical Research, LLC.
  - San Antonio, Texas, United States, 78229-3271
    - Schnitzler Cardiovascular Consultants (SCC), PLLC
  - San Antonio, Texas, United States, 78249
    - Bandera Family Healthcare Research LLC
  - Schertz, Texas, United States, 78154
    - Northeast Clinical Research of San Antonio
  - Spring, Texas, United States, 77379
    - Spring Family Practice Associates
  - Tomball, Texas, United States, 77375
    - Northwest Houston Heart Center
  - Victoria, Texas, United States, 77901
    - Victoria Heart & Vascular Center
  - Waco, Texas, United States, 76710
    - Hillcrest Family Health Clinics
- Utah
  - Farmington, Utah, United States, 84025
    - Utah Cardiology, P.C. (Davis)
- Vermont
  - White River Junction, Vermont, United States, 05055
    - VA Medical Center
- Virginia
  - Burke, Virginia, United States, 22015
    - Burke Internal Medicine & Research
  - Chesapeake, Virginia, United States, 23321
    - Virginia Endocrinology Research
  - Manassas, Virginia, United States, 20109
    - Carient Heart and Vascular
  - Richmond, Virginia, United States, 23220
    - Clinical Research Partners, LLC
  - Richmond, Virginia, United States, 23249
    - McGuire DVA Medical Center
  - Roanoke, Virginia, United States, 24014
    - Roanoke Heart Institute
  - Suffolk, Virginia, United States, 23435
    - Suffolk Multispecialty Research
  - Virginia Beach, Virginia, United States, 23462
    - Corporation Lane Internal Medicine
- Wisconsin
  - Green Bay, Wisconsin, United States, 54301
    - Cardiology Associates of Bellin Health
  - Kenosha, Wisconsin, United States, 53144
    - Clinical Investigation Specialists Inc
  - La Crosse, Wisconsin, United States, 54601
    - Mayo Clinic Health System
  - Madison, Wisconsin, United States, 53713
    - Meriter Medical Group, Inc.
  - Milwaukee, Wisconsin, United States, 53295
    - Zablocki VA Medical Center

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

16 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Description

Inclusion Criteria:

Fasting TG ≥ 200 mg/dL (2.26 mmol/L) and < 500 mg/dL (5.65 mmol/L) at Visit 1 (Screening/Enrollment Visit) or Visit 1.1 (Retest)
HDL-C ≤ 40 mg/dL (1.03 mmol/L) at Visit 1 (Screening/Enrollment Visit) or Visit 1.1 (Retest)
Type 2 diabetes of longer than 12 weeks duration documented in medical records, for example: local laboratory evidence through medical record review of elevated HbA1c (≥ 6.5% [48 mmol/mol]), elevated plasma glucose (fasting ≥ 126 mg/dL [7.0 mmol/L], 2-hour ≥ 200 mg/dL [11.1 mmol/L] during oral glucose tolerance testing, or random value ≥ 200 mg/dL with classic symptoms, or currently taking medication for treatment of diabetes; AND either
1. Age ≥ 50 years if male or ≥ 55 years if female (primary prevention cohort); OR
2. Age ≥ 18 years and established systemic atherosclerosis (secondary prevention cohort), defined as any 1 of the following:
  - i. Prior MI or ischemic (non-hemorrhagic) stroke
  - ii. Coronary angiographic lesion of ≥ 60% stenosis in a major epicardial vessel or ≥ 50% left main stenosis
  - iii. Asymptomatic carotid disease with ≥ 70% carotid artery stenosis
  - iv. Symptomatic carotid disease with ≥ 50% carotid artery stenosis
  - v. Symptomatic lower extremity PAD (ie, intermittent claudication, rest pain, lower extremity ischemic ulceration, or major amputation with either ankle-brachial index ≤ 0.9 or other diagnostic testing [eg, toe-brachial index, angiogram, or other imaging study])
  - vi. Prior arterial revascularization procedure (including coronary, carotid, or peripheral angioplasty/stenting, bypass, or atherectomy/endarterectomy)

Exclusion Criteria:

Current or planned use of fibrates or agents with PPAR-α agonist activity (eg, saroglitazar) within 6 weeks (42 days) of Visit 1 (Screening/Enrollment Visit). Note: PPAR-γ agonists (eg, glizatones such as pioglitazone and rosiglitazone) are allowed
Known sensitivity to PPAR-α agonists or tablet excipients
Initiation of, or change in, current TG-lowering therapy within 12 weeks of Visit 1 (if applicable). Note: TG-lowering therapy is defined as niacin > 100 mg/day or dietary supplements or prescription omega-3 fatty acids > 1 g/day
Type 1 diabetes mellitus

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Quadruple

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Treatment Group K-877 (pemafibrate) tablet twice daily.	Drug: K-877 0.2mg tablet Other Names: pemafibrate
Placebo Comparator: Control Group Matching K-877 placebo tablet twice daily.	Drug: Placebo K-877 matching placebo tablet

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Number of patients with first occurrence of nonfatal MI, nonfatal ischemic stroke, coronary revascularization, or CV death. Time Frame: Through study completion, an average of 4 years	Through study completion, an average of 4 years

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time to first occurrence of The 4-component composite endpoint of non-fatal MI, non-fatal ischemic stroke, hospitalization for unstable angina requiring unplanned coronary revascularization or cardiovascular death Time Frame: Through study completion, an average of 4 years		Through study completion, an average of 4 years
Time to first occurrence of the 3-component composite endpoint of non-fatal MI, non-fatal ischemic stroke, or cardiovascular death Time Frame: Through study completion, an average of 4 years		Through study completion, an average of 4 years
Time to first occurrence of any component of the primary endpoint or hospitalization for Heart failure (HF) Time Frame: Through study completion, an average of 4 years		Through study completion, an average of 4 years
Time to first occurrence of any component of the primary endpoint or all-cause mortality Time Frame: Through study completion, an average of 4 years		Through study completion, an average of 4 years
Time to first occurrence of any new or worsening Peripheral artery disease (PAD) Time Frame: Through study completion, an average of 4 years	Any new or worsening Peripheral artery disease (PAD), defined as incidence of lower extremity revascularization, intermittent claudication, rest pain, lower extremity ischemic ulceration, or major amputation with either ankle-brachial index ≤ 0.9 or other diagnostic testing (eg, toe-brachial index, angiogram, or other imaging study)	Through study completion, an average of 4 years
Time of first occurrence of individual endpoints and an analysis of total events Time Frame: Through study completion, an average of 4 years	(evaluating time to occurrence of the first and all recurrent non-fatal MI, non-fatal ischemic stroke, coronary revascularization, or cardiovascular death).	Through study completion, an average of 4 years
Incidence of cardiovascular events Time Frame: Up to 4 Years	Effect of pemafibrate vs placebo on cardiovascular events compared to known genetic polymorphisms in the PPARA gene	Up to 4 Years
Lipid Endpoints Time Frame: Week -3 to Month 4 (Visit 1 to Visit 5)	The change from Screening/Enrollment Visit (Visit 1) to Month 4 Visit (Visit 5) for the following lipid biomarkers: Total cholesterol (TC), Triglyceride(s) (TG), High-density lipoprotein cholesterol (HDL-C), non-HDL-C (calculated), Very low-density lipoprotein cholesterol (VLDL-C) (calculated), ApoA1, ApoC3, and ApoE	Week -3 to Month 4 (Visit 1 to Visit 5)
Nonfasting Remnant Cholesterol Endpoint Time Frame: Week 0 to Month 6 (Visit 2 to Visit 6)	The change from Randomization Visit (Visit 2) to Month 6 Visit (Visit 6) for nonfasting remnant cholesterol	Week 0 to Month 6 (Visit 2 to Visit 6)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Kowa Research Institute, Inc.

Collaborators

Brigham and Women's Hospital

Investigators

Study Director: Paul Ridker, MD, CCVDP & The Brigham and Women's Hospital
Study Director: Aruna Pradhan, MD, CCVDP & The Brigham and Women's Hospital

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 23, 2017

Primary Completion (Actual)

July 27, 2022

Study Completion (Actual)

July 27, 2022

Study Registration Dates

First Submitted

February 23, 2017

First Submitted That Met QC Criteria

March 1, 2017

First Posted (Actual)

March 7, 2017

Study Record Updates

Last Update Posted (Actual)

July 13, 2023

Last Update Submitted That Met QC Criteria

July 11, 2023

Last Verified

July 1, 2023

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

K-877-302

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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Study Overview

Status

Conditions

Intervention / Treatment

Detailed Description

Study Type

Enrollment (Actual)

Phase

Contacts and Locations

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Time Frame

Secondary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Collaborators and Investigators

Sponsor

Collaborators

Investigators

Publications and helpful links

General Publications

Study record dates

Study Major Dates

Study Start (Actual)

Primary Completion (Actual)

Study Completion (Actual)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Actual)

Study Record Updates

Last Update Posted (Actual)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product

Clinical Trials on Dyslipidemia

Clinical Trials on K-877

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