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Pemafibrat for at reducere kardiovaskulære resultater ved at reducere triglycerider HOS patienter med diabetes (PROMINENT) (PROMINENT)

5. september 2025 opdateret af: Kowa Research Institute, Inc.

Det primære formål med undersøgelsen er at bestemme, om pemafibrat administreret to gange dagligt vil forsinke tiden til den første forekomst af en komponent af det kliniske sammensatte endepunkt af:

ikke-dødelig myokardieinfarkt (MI)
ikke-dødelig iskæmisk slagtilfælde
koronar revaskularisering; eller
Kardiovaskulær (CV) død.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Et multiregionalt klinisk forsøg med deltagende steder i følgende lande. Indien udføres under en tidligere protokolversion på grund af lovmæssige krav.

Argentina
Brasilien
Bulgarien
Canada
Colombia
Tjekkiet
Danmark
Frankrig
Tyskland
Ungarn
Indien
Israel
Japan
Mexico
Holland
Polen
Rumænien
Den Russiske Føderation
Slovakiet
Sydafrika
Spanien
Ukraine
Det Forenede Kongerige
Forenede Stater

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

10544

Fase

Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Argentina
- - Ciudad Autonoma Buenos Aires, Argentina, C1093AAS
    - Fundacion Favaloro
  - Ciudad Autonoma Buenos Aires, Argentina, 1406
    - Consultorio Dr. Litvak Bruno
  - Ciudad Autonoma Buenos Aires, Argentina, C1119ACN
    - CIPREC
  - Ciudad Autonoma Buenos Aires, Argentina, C1179AAB
    - Investigaciones Medicas IMOBA S.R.L
  - Ciudad Autonoma Buenos Aires, Argentina, C1425AGC
    - Centro Medico Dra Laura Maffei Investigacion Clinica Aplicada
  - Ciudad Autonoma Buenos Aires, Argentina, C1425DES
    - CEDIC Centro de Investigaciones Clinicas
  - Ciudad Autonoma Buenos Aires, Argentina, C1428ART
    - Instituto Cardiovascular Buenos Aires
  - Ciudad Autonoma Buenos Aires, Argentina, C1430CKE
    - CCBR - Buenos Aires - AR
  - Corrientes, Argentina, 3400
    - Instituto de Cardiologia de Corrientes
  - Córdoba, Argentina, X5003DCE
    - Instituto Medico Damic
  - Córdoba, Argentina, X5000AAW
    - Inst. Privado de Inv. Clinicas de Cordoba
  - Córdoba, Argentina, X5016KEH
    - Hospital Privado Centro Medico de Cordoba S.A
  - Córdoba, Argentina, X5020AAA
    - Clinica del Prado
  - Salta, Argentina, A4400CRC
    - Prevencion Cardiovascular Salta
- Buenos Aires
  - Bahía Blanca, Buenos Aires, Argentina, 8000
    - Hospital Interzonal General de Agudos Dr Jose Penna
  - Bahía Blanca, Buenos Aires, Argentina, B8001HXM
    - Hospital Italiano Regional del Sur
  - Ciudad Autonoma Buenos Aires, Buenos Aires, Argentina, C1181ACH
    - Hospital Italiano
  - La Plata, Buenos Aires, Argentina, B1902AGY
    - CICLO
  - Mar del Plata, Buenos Aires, Argentina, B7600FYK
    - Centro de Investigaciones Medicas Mar Del Plata
  - Mar del Plata, Buenos Aires, Argentina, B7600FZ
    - Instituto de Investigaciones Clinicas
  - San Nicolás de los Arroyos, Buenos Aires, Argentina, B2900DMH
    - Instituto de Investigaciones Clinicas San Nicolas
  - San Nicolás de los Arroyos, Buenos Aires, Argentina, B2900DPA
    - Instituto Clinico Metabolico
  - Vicente López, Buenos Aires, Argentina, 1602
    - Clinica Olivos
- Ciudad Autonoma Buenos Aires
  - Buenos Aires, Ciudad Autonoma Buenos Aires, Argentina, C1120AAC
    - Centro Médico Viamonte SRL
  - Caba, Ciudad Autonoma Buenos Aires, Argentina, C1419GEP
    - Hospital Sírio Libanês
  - Ciudad Autonoma de Bs. As., Ciudad Autonoma Buenos Aires, Argentina, C1180AAX
    - Sanatorio Guemes
  - Villa Luro, Ciudad Autonoma Buenos Aires, Argentina, C1440CFD
    - CEMEDIC - Centro de Especialidades Medicas
- Córdoba Province
  - San Vicente, Córdoba Province, Argentina, X5006CBI
    - Centro Medico Luquez
- Tucumán Province
  - San Miguel de Tucumán, Tucumán Province, Argentina, 4000
    - Axismed S.R.L.- Clínica Mayo
Brasilien
- Federal District
  - Brasília, Federal District, Brasilien, 70200-730
    - L2IP - Instituto de Pesquisas Clínicas Ltda.
  - Brasília, Federal District, Brasilien, 70390903
    - Hospital do Coracao do Brasil
  - Brasília, Federal District, Brasilien, 70710-100
    - CECAP - Centro de Cardiologia Clínica
  - Brasília, Federal District, Brasilien, 70840-091
    - Hospital Universitario de Brasilia
  - Brasília, Federal District, Brasilien, 71655-175
    - Clínica de Endocrinologia e Metabologia Ltda.
- Goiás
  - Goiânia, Goiás, Brasilien, 74210-050
    - CARDIOINTERV Centro de Pesquisa S/S
  - Goiânia, Goiás, Brasilien, 74223-130
    - Via Medica
  - Goiânia, Goiás, Brasilien, 74605-020
    - HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás
- Minas Gerais
  - Belo Horizonte, Minas Gerais, Brasilien, 30110-060
    - Hospital Felicio Rocho
  - Belo Horizonte, Minas Gerais, Brasilien, 30150-240
    - Cardresearch - Cardiologia Assistencial
- Paraná
  - Campina Grande do Sul, Paraná, Brasilien, 83430-000
    - Sociedade Hospitalar Angelina Caron
  - Curitiba, Paraná, Brasilien, 80030-480
    - Cline Research Center (Leite PS Consultoria Medica LTDA)
  - Curitiba, Paraná, Brasilien, 80730-150
    - Núcleo de Pesquisa Clínica S/S
  - Maringá, Paraná, Brasilien, 87015-000
    - Parana Medical Research Center
- Pará
  - Belém, Pará, Brasilien, 66073-000
    - HUJBB-UFPA - Hospital Universitário João de Barros Barreto - Universidade Federal do Pará
- Rio Do Janeiro
  - Rio de Janeiro, Rio Do Janeiro, Brasilien, 22271-100
    - CCBR Brasil Centro de Pesquisas e Análises Clínicas Ltda.
- Rio Grande do Norte
  - Natal, Rio Grande do Norte, Brasilien, 59020-500
    - Eurolatino Natal Pesquisas Médicas Ltda.
- Rio Grande do Sul
  - Canoas, Rio Grande do Sul, Brasilien, 92425-900
    - Hospital Universitario
  - Passo Fundo, Rio Grande do Sul, Brasilien, 99010-080
    - Hospital Sao Vicente de Paulo
  - Pelotas, Rio Grande do Sul, Brasilien, 96015-290
    - Santa Casa de Misericordia de Pelotas
  - Porto Alegre, Rio Grande do Sul, Brasilien, 90035-903
    - Hospital de Clínicas de Porto Alegre
  - Porto Alegre, Rio Grande do Sul, Brasilien, 90035-074
    - Santa Casa de Misericordia de Porto Alegre
  - Porto Alegre, Rio Grande do Sul, Brasilien, 90430-001
    - Centro de Pesquisas em Diabetes Ltda.
  - Porto Alegre, Rio Grande do Sul, Brasilien, 90480-000
    - Centro de Pesquisa Clínica Maimônides - Maimônides Day Hospital
  - Santa Maria, Rio Grande do Sul, Brasilien, 97015-530
    - Centro de Pesquisa Médica Santa Maria Ltda.
- Santa Catarina
  - Blumenau, Santa Catarina, Brasilien, 89010-906
    - Maestri e Kormann Consultoria Medico Científica LTDA
- São Paulo
  - Campinas, São Paulo, Brasilien, 13010-001
    - Loema - Instituto de Pesquisa Clínica
  - Campinas, São Paulo, Brasilien, 13060-080
    - IPCC - Instituto de Pesquisa Clínica de Campinas
  - São Bernardo do Campo, São Paulo, Brasilien, 09780-000
    - CEMEC - Centro Multidisciplinar de Estudos Clínicos
  - São José do Rio Preto, São Paulo, Brasilien, 15090-000
    - Fundação Faculdade Regional de Medicina de São José do Rio Preto
  - São José dos Campos, São Paulo, Brasilien, 12243-280
    - ISPEM - Instituto São José dos Campos em Pesquisas Médicas
  - São Paulo, São Paulo, Brasilien, 05403-000
    - Hospital das Clinicas da Faculdade de Medicina da USP
  - São Paulo, São Paulo, Brasilien, 04266-010
    - CEPIC - Centro Paulista de Investigação Clínica e Serviços Médicos
  - São Paulo, São Paulo, Brasilien, 01228-000
    - CPQuali Pesquisa Clinica Ltda.
  - São Paulo, São Paulo, Brasilien, 01228-200
    - CPCLIN - Centro de Pesquisas Clínicas Ltda.
  - São Paulo, São Paulo, Brasilien, 01323-000
    - Clínica Paulista de Doenças Cardiovasculares Ltda.
  - São Paulo, São Paulo, Brasilien, 04208-002
    - Dr. Consulta
  - São Paulo, São Paulo, Brasilien, 05403-000
    - Incor - Instituto do Coração - HCFMUSP
  - Tatuí, São Paulo, Brasilien, 18270-170
    - IMC - Instituto de Moléstias Cardiovasculares Tatuí
  - Votuporanga, São Paulo, Brasilien, 15500-003
    - Santa Casa de Votuporanga
Bulgarien
- - Blagoevgrad, Bulgarien, 2700
    - MHAT 'Puls' AD
  - Blagoevgrad, Bulgarien, 2700
    - MHAT - Blagoevgrad, EOOD
  - Byala, Bulgarien, 7100
    - MHAT "Yuliya Vrevska - Byala", EOOD
  - Haskovo, Bulgarien, 6300
    - MHAT-Haskovo, AD
  - Pazardzhik, Bulgarien, 4400
    - MHAT - Pazardzhik AD
  - Pazardzhik, Bulgarien, 4400
    - MHAT "Higia", AD - Pazardzhik
  - Pleven, Bulgarien, 5800
    - UMHAT 'Dr. Georgi Stranski', EAD
  - Pleven, Bulgarien, 5800
    - MHAT "Sv. Pantaleymon - Pleven", OOD
  - Pleven, Bulgarien, 5800
    - SHATC Pleven EAD
  - Plovdiv, Bulgarien, 4000
    - UMHAT "Sv. Georgi", EAD
  - Plovdiv, Bulgarien, 4002
    - UMHAT "Kaspela", EOOD
  - Rousse, Bulgarien, 7013
    - MC Rusemed ltd.
  - Sofia, Bulgarien, 1309
    - MHAT - "National Heart Hospital" EAD
  - Sofia, Bulgarien, 1233
    - NMTH "Tsar Boris III"
  - Sofia, Bulgarien, 1336
    - MHAT "Lyulin", EAD
  - Sofia, Bulgarien, 1527
    - UMHAT 'Tsaritsa Yoanna - ISUL', EAD
  - Sofia, Bulgarien, 1606
    - Fourth MHAT - Sofia EAD
  - Sofia, Bulgarien, 1784
    - MC "Synexus - Sofia", EOOD
  - Sofia, Bulgarien, 1407
    - Acibadem City Clinic Tokuda Hospital Ead
  - Sofia, Bulgarien, 1233
    - Fifth MHAT - Sofia EAD
  - Sofia, Bulgarien, 1750
    - UMHAT 'Sveta Anna' AD
  - Sofia, Bulgarien, 1797
    - UMHAT "SofiaMed", OOD
  - Sofia, Bulgarien, 1431
    - UMHAT "Alexandrovska" EAD
  - Sofia, Bulgarien, 1431
    - DCC "Alexandrovska", EOOD
  - Sofia, Bulgarien, 1680
    - Diagnostic Consultation Center CONVEX EOOD
  - Sofia, Bulgarien, 1040
    - Diagnostic Consultative Center II - Sofia OOD
  - Sofia, Bulgarien, 1408
    - MC Start - d-r Todor Dimitrov EOOD
  - Sofia, Bulgarien, 1680
    - Medical Center Kalimat
  - Stara Zagora, Bulgarien, 6000
    - MC "Orfey", EOOD
  - Varna, Bulgarien, 9000
    - SHATC "Cardiolife", OOD
  - Varna, Bulgarien, 9002
    - SHATC - Varna, EOOD
  - Yambol, Bulgarien, 8600
    - MHAT "Sv. Panteleymon", AD
Canada
- - Québec, Canada, G1V 4G5
    - Institut Universitaire de cardiologie et de pneumologie de Quebec
  - Québec, Canada, G1N 4V3
    - DIEX Recherche Quebec Inc.
  - Québec, Canada, G1V 4M6
    - Clinique des Maladies Lipidiques de Québec
- Alberta
  - Calgary, Alberta, Canada, T2H 2G4
    - LMC Clinical Research Inc. (Calgary)
  - Edmonton, Alberta, Canada, T5A 4L8
    - ALTA Clinical Research Inc.
  - Edmonton, Alberta, Canada, T5H 3V9
    - Royal Alexandra Hospital, CK Hui Heart Centre
  - Red Deer, Alberta, Canada, T4N 6V7
    - The Bailey Clinic
- British Columbia
  - New Westminster, British Columbia, Canada, V3L 3W4
    - Fraser Clinical Trials Inc.
  - Surrey, British Columbia, Canada, V3V 0C6
    - Surrey Memorial Hospital
  - Vancouver, British Columbia, Canada, V5Y 3W2
    - BC Diabetes As Operated by Dr. TG Elliott, Inc.
  - Victoria, British Columbia, Canada, V8T 5G4
    - Discovery Clinical Services Ltd.
- Manitoba
  - Winnipeg, Manitoba, Canada, R2H 2A6
    - Saint Boniface General Hospital
  - Winnipeg, Manitoba, Canada, R2V 4W3
    - Rivergrove Medical Clinic
  - Winnipeg, Manitoba, Canada, R3A 1R9
    - Winnipeg Clinic
- Newfoundland and Labrador
  - St. John's, Newfoundland and Labrador, Canada, NL A1B 3V6
    - Health Sciences Centre
- Ontario
  - Barrie, Ontario, Canada, L4N 7L3
    - LMC Clinical Research Inc. (Barrie)
  - Brampton, Ontario, Canada, L6T 0G1
    - Aggarwal and Associates Ltd
  - Brampton, Ontario, Canada, L6S 0C9
    - LMC Clinical Research Inc. (Brampton)
  - Burlington, Ontario, Canada, L7M 4Y1
    - JBN Medical Diagnostic Services Inc.
  - Burlington, Ontario, Canada, L7M 4Y1
    - LMC Clinical Research dba Manna Research Inc. Burlington North
  - Cambridge, Ontario, Canada, N1R 6V6
    - Cambridge Cardiac Care Centre
  - Cambridge, Ontario, Canada, N1R 7L6
    - Joanne F. Liutkus Medicine Professional Corporation
  - Cambridge, Ontario, Canada, N1R 7R1
    - Saul Vizel Professional Medicine Corporation
  - Concord, Ontario, Canada, L4K 4M2
    - LMC Clinical Research Inc. (Thornhill)
  - Etobicoke, Ontario, Canada, M9R 4E1
    - LMC Clinical Research Inc. (Etobicoke)
  - Greater Sudbury, Ontario, Canada, P3E 5M4
    - Janik Research
  - Guelph, Ontario, Canada, N1H 1B1
    - Dawson Road Family Medical Clinic
  - Nepean, Ontario, Canada, K2J 0V2
    - LMC Clinical Research Inc. (Ottawa)
  - Oakville, Ontario, Canada, L6M1M1
    - LMC Clinical Research Inc. (Oakville)
  - Oshawa, Ontario, Canada, L1J 2K1
    - James Cha, MD
  - Ottawa, Ontario, Canada, K1H 7W9
    - The Ottawa Hospital - Riverside Campus
  - Peterborough, Ontario, Canada, K9J 0B2
    - Kawartha Cardiology Clinical Trials
  - Scarborough Village, Ontario, Canada, M1E 5E9
    - Scarborough Cardiology Research
  - Toronto, Ontario, Canada, M5B 1W8
    - St. Michael's Hospital
  - Toronto, Ontario, Canada, M4G 3E8
    - LMC Clinical Research Inc. (Bayview)
  - Toronto, Ontario, Canada, M3M 0B2
    - Humber River Hospital
  - Toronto, Ontario, Canada, M9W 4L6
    - LMC Clinical Research dba Manna Research Inc. Toronto
- Quebec
  - Chicoutimi, Quebec, Canada, G7H 7K9
    - Ecogene-21
  - Greenfield Park, Quebec, Canada, J4V 2G8
    - ViaCar Recherche Clinique Inc
  - Longueuil, Quebec, Canada, J4M 2X1
    - Centre de Dépistage et Recherche Cardiovasculaire Rive-Sud
  - Lévis, Quebec, Canada, G6V 4Z5
    - Clinique de Cardiologie de Lévis
  - Mirabel, Quebec, Canada, J7J 2K8
    - LMC Clinical Research dba Manna Research Inc. Mirabel
  - Montreal, Quebec, Canada, H1T 3Y7
    - Clinique Sante Cardio MC
  - Montreal, Quebec, Canada, H2W 1T8
    - CHUM Hôtel-Dieu
  - Montreal, Quebec, Canada, H4A 3T2
    - Applied Medical Informatics Research Inc.
  - Québec, Quebec, Canada, G3K 2P8
    - ALPHA Recherche Clinique
  - Québec, Quebec, Canada, G1G 3Y8
    - Recherche Clinique Sigma Inc.
  - Québec, Quebec, Canada, G1W 4R4
    - Clinique Médicale St-Louis (Recherche) inc d/b/a/ Centre de Recherche Saint-Louis
  - Saint-Jérôme, Quebec, Canada, J7Z 5T3
    - Recherche Médicale St-Jérôme Inc.
  - Saint-Laurent, Quebec, Canada, H4T 1Z9
    - LMC Clinical Research Inc. (Montreal)
  - Saint-Marc-des-Carrieres, Quebec, Canada, G0A 4B0
    - Centre Medical des Carrieres
Colombia
- - Barranquilla, Colombia, 080020
    - Centro de Investigacion Medico Asistencial S.A.S
  - Barranquilla, Colombia, 080020
    - IPS Centro Científico Asistencial S.A.S
  - Bogotá, Colombia, 110221
    - Dexa Diab Servicios Médicos Limitada.
  - Bogotá, Colombia, 110221
    - Solano y Terront Servicios Médicos Ltda.
  - Cartagena, Colombia, 130010
    - Centro Cardiovascular Aristides Sotomayor Santa Lucia S.A.S. - IPS ASTALUC S.A.S. IPS
  - Espinal, Colombia, 00000
    - Fundación Centro de Investigaciones Biomédicas Riescard
  - Floridablanca, Colombia, 681004
    - Fundacion Oftalmologica de Santander - FOSCAL
  - Medellín, Colombia, 050021
    - Centro de Investigación Clínica CIC
Danmark
- - Aalborg, Danmark, 9100
    - Ålborg Universitets Hospital
  - Aalborg, Danmark, 9000
    - Bioclinica
  - Aarhus, Danmark, 8200
    - Aarhus University Hospital
  - Ballerup Municipality, Danmark, 2750
    - Bioclinica
  - Copenhagen S, Danmark, 2300
    - Amager-Hvidovre Hospital
  - Esbjerg, Danmark, 6700
    - Sydvestjyds Sygehus Esbjerg
  - Glostrup Municipality, Danmark, 2600
    - Amager-Hvidovre Hospital
  - Hellerup, Danmark, 2900
    - Herlev og Gentofte Hospital
  - Herlev, Danmark, 2730
    - Herlev og Gentofte Hospital
  - Herning, Danmark, 7400
    - Regionshospitalet Herning-Hospitalsenheden Vest
  - Holbæk, Danmark, 4300
    - Holbæk Sygehus
  - Roskilde, Danmark, 4000
    - Sjællands Universitetshospital
  - Svendborg, Danmark, 5700
    - OUH
  - Vejle, Danmark, 7100
    - Bioclinica
Det Forenede Kongerige
- - Swansea, Det Forenede Kongerige, SA6 6NL
    - Morriston Hospital
- Berkshire
  - Reading, Berkshire, Det Forenede Kongerige, RG2 0TG
    - Synexus Thames
- Cornwall
  - Hayle, Cornwall, Det Forenede Kongerige, TR27 5DT
    - Mounts Bay Medical Ltd
  - Liskeard, Cornwall, Det Forenede Kongerige, PL14 3XA
    - Oak Tree Surgery
  - Penzance, Cornwall, Det Forenede Kongerige, TR18 4JH
    - The Alverton Practice
  - Torpoint, Cornwall, Det Forenede Kongerige, PL11 2TB
    - Rame Medical Limited
- Devon
  - Plymouth, Devon, Det Forenede Kongerige, PL5 3JB
    - Knowle House Surgery
  - Torquay, Devon, Det Forenede Kongerige, TQ2 7AA
    - Torbay Hospital
- Durham
  - Stockton-on-Tees, Durham, Det Forenede Kongerige, TS19 8PE
    - Synexus Clinical Research North Tees
- Essex
  - Chelmsford, Essex, Det Forenede Kongerige, CM1 7ET
    - Broomfield Hospital
- Greater London
  - London, Greater London, Det Forenede Kongerige, EC1A 7BE
    - Barts Hospital
- Greater Manchester
  - Manchester, Greater Manchester, Det Forenede Kongerige, M13 9WL
    - Manchester Royal Infirmary
  - Manchester, Greater Manchester, Det Forenede Kongerige, M15 6SX
    - Synexus Manchester Clinical Research Centre
- Lancashire
  - Blackpool, Lancashire, Det Forenede Kongerige, FY4 3AD
    - Waterloo Medical Centre
  - Chorley, Lancashire, Det Forenede Kongerige, PR7 7NA
    - Synexus Lancashire Clinical Research Centre
- Merseyside
  - Liverpool, Merseyside, Det Forenede Kongerige, L22 0LG
    - Synexus Merseyside Clinical Research Centre
- Northumberland
  - Hexham, Northumberland, Det Forenede Kongerige, NE46 1QJ
    - Synexus Hexham General Hospital
- South Glamorgan
  - Cardiff, South Glamorgan, Det Forenede Kongerige, CF15 9SS
    - Synexus Wales Clinical Research Centre
- Strathclyde
  - Glasgow, Strathclyde, Det Forenede Kongerige, G20 OSP
    - Synexus Scotland Clinical Research Centre
- Tayside Region
  - Dundee, Tayside Region, Det Forenede Kongerige, DD1 9SY
    - Ninewells Hospital
- West Midlands
  - Birmingham, West Midlands, Det Forenede Kongerige, B15 2SQ
    - Synexus Birmingham Clinical Research Centre
Forenede Stater
- Alabama
  - Birmingham, Alabama, Forenede Stater, 35233
    - University of Alabama at Birmingham
  - Birmingham, Alabama, Forenede Stater, 35235
    - Alabama Clinical Therapeutics, LLC
  - Birmingham, Alabama, Forenede Stater, 35211
    - Synexus Clinical Research US, Inc.
  - Birmingham, Alabama, Forenede Stater, 35233
    - VA Medical Center - Birmingham
  - Gulf Shores, Alabama, Forenede Stater, 36542
    - Fundamental Research, LLC
  - Mobile, Alabama, Forenede Stater, 36608
    - Mobile Heart Specialists, PC
  - Tuscumbia, Alabama, Forenede Stater, 35674
    - Terence T. Hart, MD
- Arizona
  - Chandler, Arizona, Forenede Stater, 85224-6279
    - Synexus Clinical Research US, Inc.
  - Mesa, Arizona, Forenede Stater, 85206
    - Synexus Clinical Research US, Inc.
  - Peoria, Arizona, Forenede Stater, 85381
    - Arizona Arthritis & Rheumatology Research, PLLC
  - Phoenix, Arizona, Forenede Stater, 85012
    - Phoenix Veterans Adminstration Health Care System
  - Phoenix, Arizona, Forenede Stater, 85050
    - Synexus Clinical Research US, Inc.
  - Surprise, Arizona, Forenede Stater, 85374
    - Clinical Research Institute of Arizona, LLC
  - Tucson, Arizona, Forenede Stater, 85745
    - Eclipse Clinical Research
  - Tucson, Arizona, Forenede Stater, 85712
    - Synexus Clinical Research US, Inc.
- Arkansas
  - Little Rock, Arkansas, Forenede Stater, 72205
    - Central Arkansas Veterans Healthcare System
- California
  - Alhambra, California, Forenede Stater, 91801
    - Clinical Research Alliance, Inc
  - Costa Mesa, California, Forenede Stater, 92627
    - Aurora Care Clinic
  - Escondido, California, Forenede Stater, 92025
    - AMCR Institute, Inc.
  - Huntington Beach, California, Forenede Stater, 92648-1717
    - National Institute of Clinical Research
  - Loma Linda, California, Forenede Stater, 92354
    - VA Loma Linda Healthcare System
  - Long Beach, California, Forenede Stater, 90822
    - VA Long Beach Healthcare System
  - Los Angeles, California, Forenede Stater, 90073
    - VA Greater Los Angeles Healthcare System
  - Los Angeles, California, Forenede Stater, 90022
    - Eastside Clinical Research Associates
  - Los Gatos, California, Forenede Stater, 95032
    - Richard S. Cherlin, MD
  - Northridge, California, Forenede Stater, 91324
    - Northridge Clinical Research Inc.
  - Palo Alto, California, Forenede Stater, 94304
    - Palo Alto Division
  - Pasadena, California, Forenede Stater, 91105
    - Huntington Hospital - Research Department
  - Rancho Cucamonga, California, Forenede Stater, 91730
    - Rancho Cucamonga Clinical Research
  - San Diego, California, Forenede Stater, 92119
    - MD Strategies Research Centers
  - Santa Maria, California, Forenede Stater, 93454
    - Alex Harrison, MD Inc.
  - Santa Rosa, California, Forenede Stater, 95404
    - Santa Rosa Cardiology Medical Group, Inc.
  - Vista, California, Forenede Stater, 92083
    - Blue Coast Cardiology
- Colorado
  - Aurora, Colorado, Forenede Stater, 80012
    - Lynn Institute of Denver
  - Golden, Colorado, Forenede Stater, 80401
    - New West Physicians, PC
  - Littleton, Colorado, Forenede Stater, 80127
    - Southwest Family Medicine
- Connecticut
  - Waterbury, Connecticut, Forenede Stater, 06708
    - Chase Medical Research, LLC
  - West Haven, Connecticut, Forenede Stater, 06516-2770
    - VA Connecticut Healthcare Sys
- Delaware
  - Newark, Delaware, Forenede Stater, 19713
    - Cardiology Physicians, PA
- Florida
  - Bay Pines, Florida, Forenede Stater, 33744
    - Bay Pines VA Healthcare System
  - Bradenton, Florida, Forenede Stater, 34201
    - Meridien Research
  - Brandon, Florida, Forenede Stater, 33511
    - Clinical Research of Brandon, LLC
  - Clearwater, Florida, Forenede Stater, 33756
    - Clearwater Cardiovascular Consultants
  - Daytona Beach, Florida, Forenede Stater, 32114
    - Daytona Heart Group
  - Delray Beach, Florida, Forenede Stater, 33446
    - Cohen Medical Research Associates, LLC
  - Gainesville, Florida, Forenede Stater, 32608
    - Malcom Randall VA Medical Center
  - Hollywood, Florida, Forenede Stater, 33024
    - Pines Clinical Research, Inc.
  - Homestead, Florida, Forenede Stater, 33030
    - Homestead Cardiac & Vein Center
  - Jacksonville, Florida, Forenede Stater, 32205
    - Westside Center for Clinical Research
  - Jacksonville, Florida, Forenede Stater, 32216
    - Jacksonville Center for Clinical Research
  - Jupiter, Florida, Forenede Stater, 33458
    - Health Awareness, Inc.
  - Lakeland, Florida, Forenede Stater, 33805
    - Meridien Research
  - Largo, Florida, Forenede Stater, 33777
    - Clearwater Cardiovascular & Interventional Consultants
  - Miami, Florida, Forenede Stater, 33136
    - University of Miami
  - Miami, Florida, Forenede Stater, 33174
    - Advanced Medical Research Institute
  - Ocala, Florida, Forenede Stater, 34471
    - Ocala Research Institute, Inc.
  - Ocala, Florida, Forenede Stater, 34474
    - Morgan Medical Management & Consultants Inc.
  - Ocoee, Florida, Forenede Stater, 34761
    - Endocrine Associates of Florida
  - Orlando, Florida, Forenede Stater, 32803
    - Research Physicians Network Alliance
  - Pembroke Pines, Florida, Forenede Stater, 33029
    - DBC Research, Corp
  - Pembroke Pines, Florida, Forenede Stater, 33026
    - Andres Patron, D.O., P.A
  - Pensacola, Florida, Forenede Stater, 32501
    - Langhorne Cardiology Consultants, Inc.
  - Safety Harbor, Florida, Forenede Stater, 34695
    - Clearwater Cardiovascular Consultants
  - St. Petersburg, Florida, Forenede Stater, 33713
    - Professional Health Care of Pinellas
  - Tampa, Florida, Forenede Stater, 33612
    - James A. Haley VA Medical Center
  - Winter Haven, Florida, Forenede Stater, 33880
    - Clinical Research of Central Florida
- Georgia
  - Atlanta, Georgia, Forenede Stater, 30322
    - Emory University
  - Cumming, Georgia, Forenede Stater, 30041
    - Atlanta Heart Specialists, LLC
  - Decatur, Georgia, Forenede Stater, 30033
    - VA Medical Center - Atlanta
  - Dunwoody, Georgia, Forenede Stater, 30338
    - Alta Pharmaceutical Research Center, Inc.
  - Tucker, Georgia, Forenede Stater, 30084
    - Atlanta Heart Specialists, LLC
- Illinois
  - Champaign, Illinois, Forenede Stater, 61822
    - Christie Clinic, LLC
  - Chicago, Illinois, Forenede Stater, 60607
    - Apex Medical Research, AMR, Inc.
  - Gurnee, Illinois, Forenede Stater, 60031
    - Clinical Investigation Specialists, Inc.
  - Hines, Illinois, Forenede Stater, 60141
    - Edward Hines Jr. VA Hospital
  - Normal, Illinois, Forenede Stater, 61761
    - Advocate Health and Hospitals Corp
  - North Chicago, Illinois, Forenede Stater, 60064
    - Captain James A. Lovell Federal Health Care Center
  - Olympia Fields, Illinois, Forenede Stater, 60461
    - Specialty Physicians of Illinois
- Indiana
  - Anderson, Indiana, Forenede Stater, 46011
    - Community Hospital of Anderson and Madison County, Inc.
  - Evansville, Indiana, Forenede Stater, 47714
    - Synexus Clinical Research US, Inc.
  - Evansville, Indiana, Forenede Stater, 47725
    - Deaconess Clinic
  - Indianapolis, Indiana, Forenede Stater, 46202
    - VA Medical Center - Indianapolis
  - Munster, Indiana, Forenede Stater, 46321
    - Cardiovascular Research of Northwest Indiana, LLC
  - Valparaiso, Indiana, Forenede Stater, 46383
    - Buynak Clinical Research
- Iowa
  - Council Bluffs, Iowa, Forenede Stater, 51501
    - West Broadway Clinic
  - Des Moines, Iowa, Forenede Stater, 50314
    - Iowa Diabetes and Endocrinology Research Center, PLC
  - West Des Moines, Iowa, Forenede Stater, 50266
    - The Iowa Clinic, PC
- Kansas
  - Kansas City, Kansas, Forenede Stater, 66160
    - University of Kansas Medical Center Research Institute, Inc.
  - Leavenworth, Kansas, Forenede Stater, 66048
    - VA Eastern Kansas Health Care
- Kentucky
  - Lexington, Kentucky, Forenede Stater, 40503
    - The Research Group of Lexington, LLC
  - Louisville, Kentucky, Forenede Stater, 40206
    - Robley Rex VA Medical Center
- Louisiana
  - Alexandria, Louisiana, Forenede Stater, 71301
    - Cambridge Medical Trials
  - Covington, Louisiana, Forenede Stater, 70433
    - Cardiovascular Associates Research, LLC
  - Lake Charles, Louisiana, Forenede Stater, 70601
    - Centex Studies Inc.
  - Shreveport, Louisiana, Forenede Stater, 71101
    - Overton Brooks VA Medical Center
- Maine
  - Biddeford, Maine, Forenede Stater, 04005
    - Southern Maine Health Care
- Maryland
  - Baltimore, Maryland, Forenede Stater, 21201
    - University of Maryland School of Medicine
  - Baltimore, Maryland, Forenede Stater, 21229
    - Maryland Cardiovascular Specialists
  - Baltimore, Maryland, Forenede Stater, 21201
    - Baltimore VA medical centre
  - Hyattsville, Maryland, Forenede Stater, 20782
    - Medstar Health Research Institute
  - Salisbury, Maryland, Forenede Stater, 21804
    - Delmarva Heart Research Foundation, Inc.
- Massachusetts
  - Boston, Massachusetts, Forenede Stater, 02215
    - Joslin Diabetes Center
  - Haverhill, Massachusetts, Forenede Stater, 01830
    - Pentucket Medical Associates
  - Milton, Massachusetts, Forenede Stater, 02186
    - South Shore Internal Medicine Associates
- Michigan
  - Ann Arbor, Michigan, Forenede Stater, 48105
    - University of Michigan
  - Ann Arbor, Michigan, Forenede Stater, 48105
    - Veterans Affairs Ann Arbor Healthcare System
  - Buckley, Michigan, Forenede Stater, 49620
    - Northern Pines Health Center
  - Cadillac, Michigan, Forenede Stater, 49601
    - Cadillac Clinical Research, LLC
  - Flint, Michigan, Forenede Stater, 48504
    - AA MRC LLC Ahmed Arif Medical Research Center
  - Lansing, Michigan, Forenede Stater, 48912
    - Sparrow Clinical Research Institute
  - Saginaw, Michigan, Forenede Stater, 48602
    - Covenant Medical Center, Inc.
- Minnesota
  - Minneapolis, Minnesota, Forenede Stater, 55407
    - Minneapolis Heart Institute Foundation
  - Richfield, Minnesota, Forenede Stater, 55432
    - Synexus Clinical Research US, Inc.
  - Saint Cloud, Minnesota, Forenede Stater, 56303-1900
    - CentraCare Heart & Vascular
  - Saint Paul, Minnesota, Forenede Stater, 55102
    - HealthEast Medical Research Institute
- Mississippi
  - Jackson, Mississippi, Forenede Stater, 39216
    - GV Montgomery VA Medical Center
- Missouri
  - Kansas City, Missouri, Forenede Stater, 64128
    - Kansas City VA Medical Center
  - St Louis, Missouri, Forenede Stater, 63141
    - Synexus Clinical Research US, Inc.
- Montana
  - Kalispell, Montana, Forenede Stater, 59901
    - Kalispell Regional Medical Center dba Glacier View Research Institute
- Nebraska
  - Omaha, Nebraska, Forenede Stater, 68198-4120
    - University of Nebraska Medical Center
  - Omaha, Nebraska, Forenede Stater, 68105
    - VA Nebraska-Western Iowa Health Care System
  - Papillion, Nebraska, Forenede Stater, 68046
    - Synexus Clinical Research US, Inc.
- Nevada
  - Henderson, Nevada, Forenede Stater, 89052
    - Synexus Clinical Research US, Inc.
  - Las Vegas, Nevada, Forenede Stater, 89146
    - Red Rock Clinical Research LLC
  - Reno, Nevada, Forenede Stater, 89502
    - VA Sierra Nevada Health Care System
- New Hampshire
  - Nashua, New Hampshire, Forenede Stater, 03063
    - Southern New Hampshire Diabetes and Endocrinology
- New Jersey
  - Eatontown, New Jersey, Forenede Stater, 07724
    - Monmouth Cardiology Associates
  - Linden, New Jersey, Forenede Stater, 07036
    - NJ Heart
  - Ridgewood, New Jersey, Forenede Stater, 07450
    - The Valley Hospital
- New Mexico
  - Albuquerque, New Mexico, Forenede Stater, 87108
    - Raymond G. Murphy VA Medical Center
- New York
  - Albany, New York, Forenede Stater, 12206
    - Endocrine Group, L.L.P.
  - Albany, New York, Forenede Stater, 12208
    - Stratton Veterans Affairs Medical Center - Albany
  - Buffalo, New York, Forenede Stater, 14215
    - Buffalo VA Medical Center
  - Mineola, New York, Forenede Stater, 11501
    - Winthrop Cardiology Associates
  - New York, New York, Forenede Stater, 10029
    - Icahn School of Medicine at Mount Sinai
  - Syracuse, New York, Forenede Stater, 13210
    - Suny Upstate Medical University
  - Syracuse, New York, Forenede Stater, 13210
    - VA Medical Center - Syracuse
- North Carolina
  - Asheboro, North Carolina, Forenede Stater, 27203
    - Randolph Medical Associates
  - Asheville, North Carolina, Forenede Stater, 28801
    - Onsite Clinical Solutions, LLC
  - Burlington, North Carolina, Forenede Stater, 27215
    - Kernodle Clinic, Inc., Dept. of the Private Diagnostic Clinic, PLLC
  - Cary, North Carolina, Forenede Stater, 27518
    - PMG Research of Cary, LLC
  - Cary, North Carolina, Forenede Stater, 27518
    - Cary Research Group, LLC
  - Charlotte, North Carolina, Forenede Stater, 28204
    - Novant Health - Heart and Vascular Institute
  - Charlotte, North Carolina, Forenede Stater, 28204
    - The Presbyterian Hospital
  - Charlotte, North Carolina, Forenede Stater, 28277
    - Focus Clinical Research Solutions
  - Greensboro, North Carolina, Forenede Stater, 27408
    - Medication Management, LLC
  - Greensboro, North Carolina, Forenede Stater, 27410
    - Triad Clinical Trials, LLC
  - Hickory, North Carolina, Forenede Stater, 28601
    - PMG Research of Hickory, LLC
  - Hickory, North Carolina, Forenede Stater, 28601
    - Clinical Trials of America-NC, LLC
  - Mooresville, North Carolina, Forenede Stater, 28117
    - Research Institute of the Carolinas, PLC
  - Morehead City, North Carolina, Forenede Stater, 28557
    - Diabetes and Endocrinology Consultants
  - Pinehurst, North Carolina, Forenede Stater, 28374
    - Pinehurst Medical Clinic Inc
  - Raleigh, North Carolina, Forenede Stater, 27609
    - PMG Research of Raleigh, LLC
  - Rocky Mount, North Carolina, Forenede Stater, 27804
    - PMG Research of Rocky Mount, LLC
  - Salisbury, North Carolina, Forenede Stater, 28144
    - PMG Research of Salisbury, LLC
  - Shelby, North Carolina, Forenede Stater, 28150-3803
    - Carolina Research Center, Inc.
- Ohio
  - Akron, Ohio, Forenede Stater, 44311
    - Synexus Clinical Research US, Inc.
  - Athens, Ohio, Forenede Stater, 45701
    - OhioHealth Heart & Vascular Physicians (Heartcare, Inc.) - Athens
  - Canton, Ohio, Forenede Stater, 44710
    - Aultman Hospital
  - Cincinnati, Ohio, Forenede Stater, 45215
    - Hometown Urgent Care & Occupational Health
  - Cincinnati, Ohio, Forenede Stater, 45267
    - Cincinnati Veterans Affairs Medical Center
  - Cleveland, Ohio, Forenede Stater, 44106
    - Louis Stokes Cleveland Dept of VA Medical Center
  - Franklin, Ohio, Forenede Stater, 45005
    - Prestige Clinical Research Center
  - Marion, Ohio, Forenede Stater, 43302
    - Craig S Thompson MD LLC
- Oklahoma
  - Norman, Oklahoma, Forenede Stater, 73069
    - Lynn Institute of Norman
  - Norman, Oklahoma, Forenede Stater, 73069
    - Intend Research
  - Oklahoma City, Oklahoma, Forenede Stater, 73104
    - Oklahoma City Clinic - Central
  - Oklahoma City, Oklahoma, Forenede Stater, 73135
    - South Oklahoma Heart Research Group
- Oregon
  - Medford, Oregon, Forenede Stater, 97504
    - Heart Clinic of Southern Oregon
- Pennsylvania
  - Chambersburg, Pennsylvania, Forenede Stater, 17201
    - Chambersburg Hospital
  - Feasterville, Pennsylvania, Forenede Stater, 19053
    - AMH Feasterville Family Health Care Center
  - Levittown, Pennsylvania, Forenede Stater, 19056
    - Family Medical Associates
  - Pittsburgh, Pennsylvania, Forenede Stater, 15240
    - VA Pittsburgh Healthcare System
  - Pittsburgh, Pennsylvania, Forenede Stater, 15317
    - Preferred Primary Care Physicians
  - Scottdale, Pennsylvania, Forenede Stater, 15683
    - Fay West Family Practice
  - Smithfield, Pennsylvania, Forenede Stater, 15478
    - Montgomery Medical Inc.
- Rhode Island
  - Cumberland, Rhode Island, Forenede Stater, 02864
    - Partners in Clinical Research
  - Lincoln, Rhode Island, Forenede Stater, 02865
    - Ocean State Clinical Research Partners
  - Providence, Rhode Island, Forenede Stater, 02908
    - Providence Veteran Administration Medical Center
- South Carolina
  - Anderson, South Carolina, Forenede Stater, 29621-2062
    - Synexus Clinical Research US, Inc.
  - Charleston, South Carolina, Forenede Stater, 29401
    - Ralph H. Johnson VA Medical Center
  - Greer, South Carolina, Forenede Stater, 29651
    - Mountain View Clinical Research, Inc.
  - Little River, South Carolina, Forenede Stater, 29566
    - Main Street Physician's Care - Waterway
  - Myrtle Beach, South Carolina, Forenede Stater, 29588
    - Family Medicine of Sayebrook
  - Old Point Station, South Carolina, Forenede Stater, 29707
    - Piedmont Research Partners
  - Spartanburg, South Carolina, Forenede Stater, 29302
    - Palmetto Research Center, LLC
  - Summerville, South Carolina, Forenede Stater, 29485
    - Palmetto Clinical Research
- Tennessee
  - Bristol, Tennessee, Forenede Stater, 37620
    - PMG Research of Bristol, LLC
  - Chattanooga, Tennessee, Forenede Stater, 37421
    - WR-ClinSearch, LLC
  - Chattanooga, Tennessee, Forenede Stater, 37404
    - Chattanooga Medical Research, LLC
  - Chattanooga, Tennessee, Forenede Stater, 37411
    - University Diabetes & Endocrine Consultants
  - Chattanooga, Tennessee, Forenede Stater, 37404
    - Chattanooga Research and Medicine (CHARM)
  - Kingsport, Tennessee, Forenede Stater, 37660
    - Holston Medical Group, P.C.
  - Knoxville, Tennessee, Forenede Stater, 37934
    - Metro Knoxville HMA, LLC
  - Memphis, Tennessee, Forenede Stater, 38104
    - VA Medical Center - Memphis
  - Nashville, Tennessee, Forenede Stater, 37232
    - Tennessee Valley Healthcare System
- Texas
  - Austin, Texas, Forenede Stater, 78705
    - Central Texas Clinical Research, LLC
  - Dallas, Texas, Forenede Stater, 75234
    - Synexus Clinical Research US, Inc.
  - Dallas, Texas, Forenede Stater, 75231
    - North Texas Endocrine Center
  - Dallas, Texas, Forenede Stater, 75208
    - Protenium Clinical Research
  - Dallas, Texas, Forenede Stater, 75216
    - VA Medical Center - Dallas
  - Dallas, Texas, Forenede Stater, 75231
    - Research Institute of Dallas, P.A.
  - Edinburg, Texas, Forenede Stater, 78539
    - Doctors Hospital at Renaissance
  - Fort Worth, Texas, Forenede Stater, 76132
    - Diabetes and Thyroid Center of Fort Worth
  - Fort Worth, Texas, Forenede Stater, 76104
    - Texas Health Research & Education Institute
  - Fort Worth, Texas, Forenede Stater, 76107
    - University of North Texas Health Science Center
  - Fort Worth, Texas, Forenede Stater, 76164
    - Rockwood Medical Clinic
  - Fort Worth, Texas, Forenede Stater, 76107
    - Texas Health Physicians Group
  - Houston, Texas, Forenede Stater, 77030
    - Michael E. DeBakey VA Medical Center
  - Houston, Texas, Forenede Stater, 77008
    - Heights Doctors Clinic
  - Houston, Texas, Forenede Stater, 77081
    - Southwest Clinical Trials
  - Houston, Texas, Forenede Stater, 77002
    - East Texas Cardiology PA
  - Houston, Texas, Forenede Stater, 77004
    - Endocrine Associates, LLC
  - Houston, Texas, Forenede Stater, 77027
    - Associates in Medicine
  - Hurst, Texas, Forenede Stater, 76054
    - Protenium Clinical Research
  - Pearland, Texas, Forenede Stater, 77584
    - Houston Methodist Research Institute - CCAT Pearland
  - Plano, Texas, Forenede Stater, 75075
    - Clinical Investigations of Texas
  - San Antonio, Texas, Forenede Stater, 78205
    - Consano Clinical Research, LLC
  - San Antonio, Texas, Forenede Stater, 78220
    - Sant Antonio Premiere Internal Medicine
  - San Antonio, Texas, Forenede Stater, 78224
    - Briggs Clinical Research, LLC.
  - San Antonio, Texas, Forenede Stater, 78229-3271
    - Schnitzler Cardiovascular Consultants (SCC), PLLC
  - San Antonio, Texas, Forenede Stater, 78249
    - Bandera Family Healthcare Research LLC
  - Schertz, Texas, Forenede Stater, 78154
    - Northeast Clinical Research of San Antonio
  - Spring, Texas, Forenede Stater, 77379
    - Spring Family Practice Associates
  - Tomball, Texas, Forenede Stater, 77375
    - Northwest Houston Heart Center
  - Victoria, Texas, Forenede Stater, 77901
    - Victoria Heart & Vascular Center
  - Waco, Texas, Forenede Stater, 76710
    - Hillcrest Family Health Clinics
- Utah
  - Farmington, Utah, Forenede Stater, 84025
    - Utah Cardiology, P.C. (Davis)
- Vermont
  - White River Junction, Vermont, Forenede Stater, 05055
    - VA Medical Center
- Virginia
  - Burke, Virginia, Forenede Stater, 22015
    - Burke Internal Medicine & Research
  - Chesapeake, Virginia, Forenede Stater, 23321
    - Virginia Endocrinology Research
  - Manassas, Virginia, Forenede Stater, 20109
    - Carient Heart and Vascular
  - Richmond, Virginia, Forenede Stater, 23220
    - Clinical Research Partners, LLC
  - Richmond, Virginia, Forenede Stater, 23249
    - McGuire DVA Medical Center
  - Roanoke, Virginia, Forenede Stater, 24014
    - Roanoke Heart Institute
  - Suffolk, Virginia, Forenede Stater, 23435
    - Suffolk Multispecialty Research
  - Virginia Beach, Virginia, Forenede Stater, 23462
    - Corporation Lane Internal Medicine
- Wisconsin
  - Green Bay, Wisconsin, Forenede Stater, 54301
    - Cardiology Associates of Bellin Health
  - Kenosha, Wisconsin, Forenede Stater, 53144
    - Clinical Investigation Specialists Inc
  - La Crosse, Wisconsin, Forenede Stater, 54601
    - Mayo Clinic Health System
  - Madison, Wisconsin, Forenede Stater, 53713
    - Meriter Medical Group, Inc.
  - Milwaukee, Wisconsin, Forenede Stater, 53295
    - Zablocki VA Medical Center
Frankrig
- Indre Et Loire
  - Chambray-lès-Tours, Indre Et Loire, Frankrig, 37170
    - CHU Tours - Hôpital TROUSSEAU
- Loire Atlantique
  - Nantes, Loire Atlantique, Frankrig, 44093
    - CHU Nantes - Hopital Nord Laënnec
- Paris
  - Paris, Paris, Frankrig, 75877
    - Hôpital Bichat - Claude Bernard
Holland
- - Alkmaar, Holland, 1815 JD
    - Noordwest Ziekenhuisgroep
  - Almelo, Holland, 7609 PP
    - Ziekenhuisgroep Twente, Almelo
  - Amersfoort, Holland, 3813 TZ
    - Meander Medisch Centrum
  - Amstelveen, Holland, 1186 AM
    - Ziekenhuis Amstelland
  - Amsterdam, Holland, 1105 AZ
    - Amsterdam UMC, locatie AMC
  - Amsterdam, Holland, 1034 CS
    - BovenlJ Ziekenhuis
  - Apeldoorn, Holland, 7334 DZ
    - Gelre ziekenhuizen, locatie Lukas
  - Arnhem, Holland, 6815 AD
    - Rijnstate
  - Deventer, Holland, 7416 SE
    - Deventer Ziekenhuis
  - Dordrecht, Holland, 3318 AT
    - Albert Schweitzer Ziekenhuis, Dordwijk
  - Ede, Holland, 6716 RP
    - Gelderse Vallei Ziekenhuis, Ede
  - Eindhoven, Holland, 5623 EJ
    - Catharina Ziekenhuis Eindhoven
  - Haarlem, Holland, 2035 RC
    - Spaarne Gasthuis, Hoofddorp
  - Heerlen, Holland, 6419 PC
    - Zuyderland Medisch Centrum - Heerlen
  - Hoogezand, Holland, 9603 AE
    - Huisartsenpraktijk Gorecht
  - Kloosterhaar, Holland, 7694 AC
    - Quality Care Research
  - Leiden, Holland, 2333 ZA
    - Leids Universitair Medisch Centrum
  - Roosendaal, Holland, 4708 AE
    - Bravis Ziekenhuis, Roosendaal
  - Rotterdam, Holland, 3083 AN
    - Ikazia Ziekenhuis
  - Rotterdam, Holland, 3079 DZ
    - Maasstad Ziekenhuis, Zuider
  - Sliedrecht, Holland, 3331 LZ
    - Albert Schweitzer Ziekenhuis, Zwijndrecht
  - The Hague, Holland, 2545 AA
    - Haga Ziekenhuis
  - Uden, Holland, 5406 PT
    - Bernhoven Uden
  - Utrecht, Holland, 3508 GA
    - UMC Utrecht
  - Utrecht, Holland, 3582 KE
    - Diakonessenhuis, Utrecht
  - Veldhoven, Holland, 5504 DB
    - Máxima Medisch Centrum
  - Venlo, Holland, 5912 BL
    - Viecuri Medisch Centrum
Indien
- - Delhi, Indien, 110052
    - Maharaja Agrasen Hospital
- Andhra Pradesh
  - Nellore, Andhra Pradesh, Indien, 524001
    - Vijaya Super Speciality Hospital
- Assam
  - Guwahati, Assam, Indien, 781006
    - GNRC Hospital
- Gujarat
  - Ahmedabad, Gujarat, Indien, 380015
    - Ahmedabad Bariatrics and Cosmetics Pvt Ltd.
  - Ahmedabad, Gujarat, Indien, 380054
    - S. A. L. Hospital & Medical Institute
  - Nadiād, Gujarat, Indien, 387002
    - DDMM Heart Institute
  - Surat, Gujarat, Indien, 395009
    - BAPS Pramukhswami Hospital
  - Surat, Gujarat, Indien, 395002
    - Shri B. D. Mehta Mahavir Heart Institute
  - Vadodara, Gujarat, Indien, 390007
    - Sterling Hospital
  - Vadodara, Gujarat, Indien, 391740
    - Rhythm Heart Institute
- Haryana
  - Gurgaon, Haryana, Indien, 122001
    - Medanta The Medicity
- Karnataka
  - Bangalore, Karnataka, Indien, 560052
    - Fortis Hospitals Ltd.
  - Belagavi, Karnataka, Indien, 590010
    - K.L.E. Society's Dr. Prabhakar Kore Hospital and Medical Research Centre
  - Mysuru, Karnataka, Indien, 570004
    - JSS Hospital
- Kerala
  - Thiruvananthapuram, Kerala, Indien, 695 011
    - Medical College
- Maharashtra
  - Nagpur, Maharashtra, Indien, 440010
    - Meditrina Institute Of Medical Sciences
  - Nashik, Maharashtra, Indien, 422002
    - Supe Heart & Diabetes Hospital & Research Centre
  - Pimpri-Chinchwad, Maharashtra, Indien, 411033
    - 7-Orange Hospital
  - Pune, Maharashtra, Indien, 411006
    - Shree Multispecialty Hospital
  - Pune, Maharashtra, Indien, 411011
    - King Edward Memorial Hospital Research Centre
  - Ulhasnagar, Maharashtra, Indien, 421001
    - Aashirwad Hospital
- National Capital Territory of Delhi
  - New Delhi, National Capital Territory of Delhi, Indien, 110060
    - Sir Gangaram Hospital
  - New Delhi, National Capital Territory of Delhi, Indien, 110070
    - Fortis Flight Lieutenant Rajan Dhall Hospital
  - New Delhi, National Capital Territory of Delhi, Indien, 110002
    - Loknayak Hospital
- Odisha
  - Bhubaneshwar, Odisha, Indien, 751003
    - Institute of Medical Sciences and Sum Hospital
- Rajasthan
  - Jaipur, Rajasthan, Indien, 302020
    - Eternal Heart Care Centre
- Tamil Nadu
  - Chennai, Tamil Nadu, Indien, 600026
    - SRM Institutes for Medical Sciences
  - Chennai, Tamil Nadu, Indien, 600037
    - Institute of Cardiovascular Diseases Madras Medical Mission
- Uttar Pradesh
  - Lucknow, Uttar Pradesh, Indien, 226010
    - KRM Hospital & Research Centre
  - Varanasi, Uttar Pradesh, Indien, 221010
    - Galaxy Hospital
- West Bengal
  - Kolkata, West Bengal, Indien, 700020
    - IPGMER and SSKM Hospital
Israel
- - Afula, Israel, 18101
    - Haemek Medical Center
  - Haifa, Israel, 34362
    - The Lady Davis Carmel Medical Center
  - Haifa, Israel, 31048
    - Bnai Zion Medical Center
  - Haifa, Israel, 3109601
    - Rambam Health Care Center
  - Holon, Israel, 58100
    - Wolfson Medical Center
  - Jerusalem, Israel, 91031
    - Shaare Zedek Medical Center
  - Jerusalem, Israel, 91120
    - Hadassah University Hospital - Ein Kerem
  - Nahariya, Israel, 2210001
    - Galilee Medical Center
  - Petah Tikva, Israel, 49100
    - Rabin Medical Center-Beilinson Campus
  - Ramat Gan, Israel, 52621
    - Chaim Sheba Medical Center
  - Rehovot, Israel, 7610001
    - Kaplan Medical Center
  - Safed, Israel, 13100
    - Ziv Medical Center
  - Tel Aviv, Israel, 6423906
    - Tel Aviv Sourasky Medical Center
  - Tel Aviv, Israel, 6937947
    - Diabetes Medical Center
Japan
- Aichi-ken
  - Nagakute-shi, Aichi-ken, Japan, 480-1195
    - Aichi Medical University Hospital
  - Nagoya, Aichi-ken, Japan, 455-8530
    - JOHAS Chubu Rosai Hospital
  - Nagoya, Aichi-ken, Japan, 457-8511
    - Kojunkai Daido Clinic
  - Nagoya, Aichi-ken, Japan, 460-0001
    - NHO Nagoya Medical Center
  - Obu-shi, Aichi-ken, Japan, 474-8511
    - National Center for Geriatrics and Gerontology
  - Toyoake-shi, Aichi-ken, Japan, 470-1192
    - Fujita Health University Hospital
- Chiba
  - Chiba, Chiba, Japan, 260-8677
    - Chiba University Hospital
  - Matsudo-shi, Chiba, Japan, 270-2251
    - Kioroshikai Chibanishi General Hospital
  - Matsudo-shi, Chiba, Japan, 271-0077
    - Seikeikai New Tokyo Heart Clinic
- Ehime
  - Matsuyama, Ehime, Japan, 790-0024
    - Ehime Prefectural Central Hospital
- Fukuoka
  - Fukuoka, Fukuoka, Japan, 814-0180
    - Fukuoka University Hospital
  - Kasuga-shi, Fukuoka, Japan, 816-0864
    - Fukuoka Tokushukai Hospital
  - Kitakyushu-shi, Fukuoka, Japan, 805-8508
    - Steel Memorial Yawata Hospital
  - Koga-shi, Fukuoka, Japan, 811-3195
    - NHO Fukuoka Higashi Medical Center
  - Onga-gun, Fukuoka, Japan, 807-0051
    - Chiyukai Fukuoka Shinmizumaki Hospital
- Fukushima
  - Koriyama-shi, Fukushima, Japan, 963-8052
    - Southern TOHOKU Medical Clinic
  - Koriyama-shi, Fukushima, Japan, 963-8501
    - Hoshi General Hospital
- Hiroshima
  - Fuchu-shi, Hiroshima, Japan, 726-0013
    - Nakahama Heart Clinic
  - Fukuyama-shi, Hiroshima, Japan, 721-0927
    - Nippon Kokan Fukuyama Hospital
  - Higashihiroshima-shi, Hiroshima, Japan, 739-0041
    - NHO Higashihiroshima Medical Center
- Hokkaido
  - Sapporo, Hokkaido, Japan, 063-0826
    - Miyanosawa Clinic of Internal Medicine and Cardiology
- Ibaraki
  - Hitachi-Naka, Ibaraki, Japan, 312-0032
    - Tanaka Cardiology Clinic
  - Naka, Ibaraki, Japan, 311-0113
    - Nakakinen Clinic Medical Corporation Kensei-kai
- Ishikawa-ken
  - Hakusan-shi, Ishikawa-ken, Japan, 924-8588
    - Public Central Hospital of Matto Ishikawa
  - Komatsu-shi, Ishikawa-ken, Japan, 923-8560
    - NHI Komatsu Municipal Hospital
- Iwate
  - Morioka, Iwate, Japan, 020-0866
    - Kuonkai Kamata Medical Clinic
  - Morioka, Iwate, Japan, 020-8505
    - Iwate Medical University Uchimaru Medical Center Hospital
- Kagawa-ken
  - Takamatsu, Kagawa-ken, Japan, 760-0076
    - Josuikai Olive Takamatsu Medical Clinic
- Kanagawa
  - Sagamihara-shi, Kanagawa, Japan, 252-0311
    - Sohken Yamamoto Clinic
  - Yokohama, Kanagawa, Japan, 245-8575
    - NHO Yokohama Medical Center
- Kumamoto
  - Kumamoto, Kumamoto, Japan, 860-8556
    - Kumamoto University Hospital
  - Tamana-shi, Kumamoto, Japan, 865-0016
    - Ryubokai Higashi Diabetes and Cardiovascular Clinic
- Kyoto
  - Kyoto, Kyoto, Japan, 606-8507
    - Kyoto University Hospital
  - Kyoto, Kyoto, Japan, 601-1495
    - Ijinkai Takeda General Hospital
  - Kyoto, Kyoto, Japan, 607-8062
    - Rakuwakai Otowa Hospital
- Miyagi
  - Osaki-shi, Miyagi, Japan, 989-6143
    - Sato Hospital
  - Sendai, Miyagi, Japan, 980-0873
    - Sendai Kousei Hospital
  - Sendai, Miyagi, Japan, 980-0803
    - Tohoku Kosai Hospital
- Oita Prefecture
  - Ōita, Oita Prefecture, Japan, 870-0192
    - Keiwakai Oita Oka Hospital
- Okayama-ken
  - Okayama, Okayama-ken, Japan, 700-8558
    - Okayama University Hospital
- Okinawa
  - Nakagami-gun, Okinawa, Japan, 901-2393
    - Okinawa Tokushukai Chubu Tokushukai Hospital
- Osaka
  - Higashiosaka-shi, Osaka, Japan, 577-0802
    - Iwasaki Naika Clinic
  - Higashiosaka-shi, Osaka, Japan, 577-0803
    - Takekawa Naika Clinic
  - Izumisano, Osaka, Japan, 598-8577
    - Rinku General Medical Center
  - Kashiwara-shi, Osaka, Japan, 582-0005
    - Shiraiwa Medical Clinic
  - Kishiwada-shi, Osaka, Japan, 596-8522
    - Tokushukai Kishiwada Tokushukai Hospital
  - Osaka, Osaka, Japan, 553-0003
    - Kansai Electric Power Hospital
  - Suita-shi, Osaka, Japan, 564-8565
    - National Cerebral and Cardiovascular Center
  - Toyonaka-shi, Osaka, Japan, 560-0082
    - Senrichuo Ekimae Clinic
- Saitama
  - Iruma-gun, Saitama, Japan, 354-0041
    - IMS Miyoshi General Hospital
  - Kawaguchi-shi, Saitama, Japan, 332-0012
    - Sugiura Clinic
  - Tokorozawa-shi, Saitama, Japan, 359-1141
    - Sanyukai Saino Clinic
  - Wako-shi, Saitama, Japan, 351-0102
    - NHO Saitama National Hospital
- Shiga
  - Ōtsu, Shiga, Japan, 520-2192
    - Shiga University of Medical Science Hospital
- Shimane
  - Hamada-shi, Shimane, Japan, 697-8511
    - NHO Hamada Medical Center
- Tochigi
  - Shimotsuke-shi, Tochigi, Japan, 329-0498
    - Jichi Medical University Hospital
- Tokyo-To
  - Bunkyō City, Tokyo-To, Japan, 113-8431
    - Juntendo University Hospital
  - Chūōku, Tokyo-To, Japan, 103-0027
    - Fukuwa Clinic
  - Chūōku, Tokyo-To, Japan, 103-0027
    - Tokyo-Eki Center-building Clinic
  - Itabashi-ku, Tokyo-To, Japan, 173-0004
    - Nomura Clinic
  - Katsushika-ku, Tokyo-To, Japan, 124-0021
    - Hosoda Clinic
  - Meguro-ku, Tokyo-To, Japan, 153-0053
    - Toyukai Yutenji Medical Clinic (Yutenji Naika)
  - Shinjuku-ku, Tokyo-To, Japan, 169-0073
    - Shinjuku Research Park Clinic
- Yamaguchi
  - Ube-shi, Yamaguchi, Japan, 755-8505
    - Yamaguchi University Hospital
Mexico
- - Aguascalientes, Mexico, 20230
    - Centro de Investigacion Cardiometabolica de Aguascalientes S.A de C.V
  - Chihuahua City, Mexico, 31237
    - Investigacion En Salud Y Metabolismo S.C.
  - Veracruz, Mexico, 91900
    - Sociedad de Metabolismo y Corazon S.C
- Baja California Norte
  - Tijuana, Baja California Norte, Mexico, 22500
    - Centro de Investigacion Cardiovascular y Metabólica
- Guerrero
  - Acapulco de Juárez, Guerrero, Mexico, 39670
    - Centro de Investigacion Clinica del Pacifico, S.A. de C.V.
- Jalisco
  - Guadalajara, Jalisco, Mexico, 44670
    - Cardiologia Clinica e Intervencionista
  - Zapopan, Jalisco, Mexico, 45116
    - Centro de Investigacion Medica de Occidente, S.C.
- Mexico City
  - Mexico City, Mexico City, Mexico, 03100
    - Phytomedicamenta S.A. de C.V.
  - Mexico City, Mexico City, Mexico, 03810
    - Health Pharma Professional Research S.A. de C.V.
  - Mexico City, Mexico City, Mexico, 06700
    - Centro de Atención e Investigación en Factores de Riesgo Cardiovascular Omega S.C.
  - Mexico City, Mexico City, Mexico, 14080
    - Instituto Nacional de Ciencias Medicas y Nutricion Dr. Salvador Zubiran
  - Mexico City, Mexico City, Mexico, 67000
    - Mentrials S.A. de C.V.
- Morelos
  - Cuautla, Morelos, Mexico, 62746
    - Instituto de Diabetes, Obesidad y Nutrición S.C.
- Nuevo León
  - Monterrey, Nuevo León, Mexico, 64460
    - Universidad Autonoma de Nuevo Leon, Hospital Universitario Dr. Jose Eleuterio Gonzalez
  - Monterrey, Nuevo León, Mexico, 64710
    - Centro Medico San Francisco
  - San Nicolás de los Garza, Nuevo León, Mexico, 66465
    - Unidad Médica para la Salud Integral
- Querétaro
  - San Juan del Río, Querétaro, Mexico, 76800
    - Centro Integral Medico SJR S.C.
- Tamaulipas
  - Madero, Tamaulipas, Mexico, 89440
    - Centro de Estudios de Investigacion Metabolicos y Cardiovasculares S.C.
Polen
- - Bydgoszcz, Polen, 85-231
    - NZOZ Centrum Medyczne KERmed
  - Elblag, Polen, 82-300
    - KARDIOMED Janczska Kociwska Ostki PodckaRekrzSp
  - Gdansk, Polen, 80-952
    - Uniwersyteckie Centrum Kliniczne
  - Gdansk, Polen, 80-286
    - Poradnia Kardiologiczna Jarosław Jurowiecki
  - Gdansk, Polen, 80-382
    - Synexus Polska SCM Sp. z o.o. Gdansku
  - Gdynia, Polen, 81-537
    - Synexus Polska Sp. z o.o. Oddzial w Gdyni
  - Gdynia, Polen, 81-157
    - Indywidualna Specjalistyczna Praktyka Lekarska w Dziedzinie Kardiologii Lek. med. Krzysztof Cymerman
  - Grodzisk Mazowiecki, Polen, 05-825
    - Samodzielny Publiczny Specjalistyczny Szpital Zachodni im. Jana Pawla II
  - Katowice, Polen, 40-040
    - Synexus Polska Sp. Z O.O. Oddzial W Katowicach
  - Katowice, Polen, 40-084
    - Centrum Medyczne Pratia Katowice II
  - Katowice, Polen, 40-635
    - SPSK Nr 7 SUM w Katowicach Gornoslaskie CM im. prof. Leszka Gieca
  - Kielce, Polen, 25-525
    - Specjalistyczna Poradnia Kardiologiczna i Nadcisnienia Tetniczego
  - Krakow, Polen, 31-501
    - Krakowskie Centrum Medyczne Sp. z o.o.
  - Krakow, Polen, 30-363
    - Augustyn Monika
  - Lodz, Polen, 94-255
    - Indywidualna Specjalistyczna Praktyka Lekarska
  - Lodz, Polen, 93-513
    - Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Łodzi
  - Lodz, Polen, 94-048
    - NZOZ ALL-MED Centrum Medyczne Specjalistyczne Gabinety Lekarskie
  - Lublin, Polen, 20-362
    - KO-MED Centra Kliniczne Lublin II
  - Lublin, Polen, 20-709
    - Clinical Best Solutions
  - Lublin, Polen, 20-857
    - NZOZ Twoja Przychodnia
  - Nałęczów, Polen, 24-140
    - NZOZ Osrodek Kardiologii Inwazyjnej -Ikardia
  - Oświęcim, Polen, 32-600
    - Medicome Sp. z o.o.
  - Poznan, Polen, 60-702
    - Synexus Polska Sp. z o.o. Oddzial w Poznaniu
  - Poznan, Polen, 61-655
    - Praktyka Lekarska Ewa Krzyzagorska
  - Puławy, Polen, 24-100
    - KO-MED Centra Kliniczne Pulawy
  - Ruda Śląska, Polen, 41-709
    - NZOZ Przychodnia Specjalistyczna H. Rudzki, A. Wittek
  - Rzeszów, Polen, 35-055
    - Centrum Medyczne MEDYK
  - Skierniewice, Polen, 96-100
    - Clinmed Research
  - Sopot, Polen, 81-717
    - NZOZ Pro-Cordis Sopockie Centrum Bad. Kardiolog.
  - Staszów, Polen, 28-200
    - Ko-Med Centra Kliniczne Staszow
  - Szczecin, Polen, 71-531
    - Indywidualna Specjalistyczna Praktyka Lekarska dr n. med. Agnieszka Karczmarczyk Specjalista Chorob
  - Warsaw, Polen, 00-465
    - Nbr Polska
  - Warsaw, Polen, 01-192
    - Synexus Polska Sp. z o.o. Oddział w Warszawie
  - Warsaw, Polen, 00-631
    - Centrum Medyczne Świat Pacjenta
  - Wierzchosławice, Polen, 33-122
    - Centrum Zdrowia Tuchow Sp. z o.o.
  - Wroclaw, Polen, 50-381
    - Synexus Polska Sp. z o.o. Oddział we Wroclawiu
  - Zamość, Polen, 22-400
    - KO-MED Centra Kliniczne Zamosc
  - Środa Wielkopolska, Polen, 63-000
    - NSZOZ Medicus
Puerto Rico
- - San Juan, Puerto Rico, 00927-5800
    - VA Medical Center - San Juan
Rumænien
- - Bacau, Rumænien, 600154
    - S.C. CMI Dr. Pletea Noemi S.R.L
  - Baia Mare, Rumænien, 430222
    - Cabinet Medical Individual Diabet, Nutritie, Boli Metabolice Dr. Pop Lavinia
  - Brasov, Rumænien, 500283
    - S.C Centrul Medical de Diagnostic si Tratament Ambulator Neomed S.R.L
  - Bucharest, Rumænien, 020125
    - Spitalul Clinic Colentina
  - Bucharest, Rumænien, 022328
    - Institutul de Urgenta pentru Boli Cardiovasculare "Prof. Dr. C.C. Iliescu"
  - Bucharest, Rumænien, 010192
    - S.C Clinica Medicala Data Plus S.R.L
  - Bucharest, Rumænien, 021659
    - Spitalul Clinic de Urgenta "Sfantul Pantelimon"
  - Bucharest, Rumænien, 030088
    - S.C. Health Net S.R.L
  - Bucharest, Rumænien, 030463
    - S.C Policlinica Ccbr S.R.L
  - Bucharest, Rumænien, 061072
    - CMI Dr. Stolea T. Violeta - Medic specialist diabet zaharat, nutritie si boli metabolice
  - Buzău, Rumænien, 120203
    - S.C. Medcon S.R.L.
  - Oradea, Rumænien, 410159
    - S.C Grandmed S.R.L
  - Oradea, Rumænien, 410469
    - S.C Pelican Impex S.R.L
  - Pașcani, Rumænien, 705200
    - S.C. Bella Praxis S.R.L
  - Ploieşti, Rumænien, 100163
    - S.C. Diabmed Dr. Popescu Alexandrina S.R.L
  - Ploieşti, Rumænien, 100342
    - CMI Dr Busegeanu Mihaela Magdalena
  - Timișoara, Rumænien, 300359
    - S.C Medicali's S.R.L
  - Timișoara, Rumænien, 300723
    - Spitalul Clinic Judetean de Urgenta "Pius Brinzeu"
  - Târgu Mureş, Rumænien, 540142
    - S.C Mediab S.R.L
Rusland
- - Arkhangelsk, Rusland, 163001
    - SBIH of Arkhangelsk region " First City Clinical hospital n.a. E. E. Volosevich"
  - Barnaul, Rusland, 656055
    - TSHI "Altay Territorial Cardiologocal dispensary"
  - Kemerovo, Rusland, 650066
    - SAIH "Kemerovo Regional Clinical Hospital"
  - Kemerovo, Rusland, 650000
    - FSHI "MSU of MoIA of RF of Kemerovo Region"
  - Kemerovo, Rusland, 650002
    - FSBI "Scientific-research Institute for Complex Problems of cardiovascular disease"
  - Kemerovo, Rusland, 650055
    - NSIH "Departmental Hospital on Station Kemerovo of OJSC "Russian Railways"
  - Krasnoyarsk, Rusland, 660062
    - TSBIH "Krasnoyarsk Interdistrict Clinical Hospital of Emergency Medical Care n.a. N.S. Karpovich
  - Moscow, Rusland, 107 014
    - SBIH of Moscow "City Clinical Hospital n.a.Bakhrushinykh"
  - Moscow, Rusland, 117556
    - SBHI "City Polyclinic #2 of Healthcare department of city of Moscow"
  - Moscow, Rusland, 117593
    - FSBIH "Central Clinical Hospital of Russian Academy of Sciences"
  - Moscow, Rusland, 121359
    - FSBI "Central Clinical Hospital with Polyclinic of the Department for Presidential Affairs of the RF
  - Moscow, Rusland, 127473
    - SBEI HPE "Moscow State Medical and Dentistry University n.a. A. I. Evdokimov" of the MoH of the RF
  - Moscow, Rusland, 129301
    - SBEI HPE "Moscow State Medical and Dentistry University n.a. A. I. Evdokimov" of the MoH of the RF
  - Murmansk, Rusland, 183047
    - Murmansk Regional Clinical Hospital named after Bayandin
  - Novosibirsk, Rusland, 630008
    - SBIH of Novosibirsk Region "Clinical Emergency Hospital #2"
  - Novosibirsk, Rusland, 630068
    - SBIH of Novosibirsk region "City Clinical Hospital # 19"
  - Novosibirsk, Rusland, 630089
    - FSBSI "Scientific Research Institute of Therapy and Preventive Medicine"
  - Novosibirsk, Rusland, 630091
    - LLC "RC Medical"
  - Omsk, Rusland, 644024
    - Llc Ultramed
  - Omsk, Rusland, 644018
    - BIH of Omsk region "Clinical Medico-Sanitary Unit # 9
  - Perm, Rusland, 614068
    - SBIH of Perm territory " City Clinical Hospital # 2 n.a. Fedor Khristoforovich Gral"
  - Perm, Rusland, 614077
    - State Budgetary Healthcare Institution Clinical Medical Sani
  - Perm, Rusland, 614097
    - SHI "Perm Regional Hospital of War Veterans"
  - Rostov-on-Don, Rusland, 344068
    - City Emergency Hospital #2
  - Saint Petersburg, Rusland, 197022
    - Pavlov First Saint Petersburg State Medical University
  - Saint Petersburg, Rusland, 190013
    - CJSC Clinic complex
  - Saint Petersburg, Rusland, 194156
    - FSBI North-West Federal Medical Research Center n.a. V.A. Almazov of MoH RF
  - Saint Petersburg, Rusland, 194354
    - SPb SBIH "City Multy-field Hospital # 2"
  - Saint Petersburg, Rusland, 195427
    - Saint-Petersburg SBHI "City outpatient clinic #28"
  - Saint Petersburg, Rusland, 196084
    - LLC "Institute of Medical Examinations"
  - Saint Petersburg, Rusland, 197136
    - Llc "Medinet"
  - Saint Petersburg, Rusland, 198510
    - SPb SBIH "Nikolaevskaya Hospital"
  - Saint Petersburg, Rusland, 199106
    - SPb SBIH "City Pokrovskaya Hospital"
  - Saint Petersburg, Rusland, 199178
    - LLC Medical Center Mart
  - Saratov, Rusland, 410028
    - SIH "Saratov City Clinical Hospital # 2 n.a. V.I. Razumovskiy"
  - Sestroretsk, Rusland, 197706
    - SPb SBIH "City Hospital # 40 of Kurortnyi region"
  - Tomsk, Rusland, 634012
    - FSBI "Research Institute for Cardiology" of Siberian Branch RAMS
  - Tver', Rusland, 170036
    - SHI "Regional Clinical Hospital"
  - Ulyanovsk, Rusland, 432063
    - SHI Ulyanovsk Reg Clinical Hospital
  - Yaroslavl, Rusland, 150047
    - Yaroslavl Regional Clinical Hospital of War Veterans
  - Yekaterinburg, Rusland, 620026
    - SEIHPE "Ural SMA of RosZdrav" b.o. LLC "City Hospital #41"
Slovakiet
- - Bardejov, Slovakiet, 085 01
    - ALIAN s.r.o.
  - Bardejov, Slovakiet, 08501
    - Thyreomedical s.r.o.
  - Bratislava, Slovakiet, 81108
    - Metabol KLINIK s.r.o.
  - Bratislava, Slovakiet, 821 07
    - Galenum, s.r.o.
  - Bratislava, Slovakiet, 82102
    - DIAFA s.r.o.
  - Bratislava, Slovakiet, 82108
    - Diabet, spol. s.r.o.
  - Bratislava, Slovakiet, 83101
    - Kardiovaskularne centrum, s.r.o.
  - Bratislava, Slovakiet, 84108
    - Kardiologicka, interna a sonograficka amb. Kardio-Sanus, sro
  - Bratislava, Slovakiet, 85101
    - MEDISPEKTRUM PLUS s.r.o.
  - Bratislava, Slovakiet, 85101
    - MUDr. Vladimir Gergel, s.r.o.
  - Dolný Kubín, Slovakiet, 02601
    - ENDIAMED, s.r.o.
  - Komárno, Slovakiet, 94501
    - MEDICUS plus s.r.o.
  - Košice, Slovakiet, 04001
    - Human-Care s.r.o.
  - Košice, Slovakiet, 04001
    - Sukromna interna a kardiologicka ambulancia
  - Levice, Slovakiet, 93401
    - DIA- Kontrol s.r.o.
  - Levice, Slovakiet, 93405
    - CELL B, s.r.o.
  - Lučenec, Slovakiet, 98401
    - IN-DIA s.r.o.
  - Lučenec, Slovakiet, 984 39
    - KARDIO 1 s.r.o.
  - Nitra, Slovakiet, 94911
    - MUDr. Zuzana Ochodnicka,
  - Nové Zámky, Slovakiet, 94002
    - Fakultna nemocnica s poliklinikou Nove Zamky
  - Prešov, Slovakiet, 08001
    - Medispol s.r.o.
  - Prešov, Slovakiet, 08001
    - DIABETOL s.r.o.
  - Rožňava, Slovakiet, 04801
    - Nemocnica s poliklinikou sv. Barbory Roznava a.s.
  - Svidník, Slovakiet, 08901
    - Interna SK s.r.o.
  - Svidník, Slovakiet, 08901
    - Nemocnica arm. generala L. Svobodu Svidnik, a.s.,
  - Trenčín, Slovakiet, 91101
    - Diabetes centrum, s.r.o.
  - Trnava, Slovakiet, 91701
    - JAL s.r.o.
  - Šahy, Slovakiet, 93601
    - Peter Farkas MD, s.r.o.
  - Žilina, Slovakiet, 01001
    - MEDIVASA s.r.o.
Spanien
- - Almería, Spanien, 04120
    - Hospital Virgen del Mar
  - Barcelona, Spanien, 08003
    - Hospital del Mar
  - Barcelona, Spanien, 08025
    - Hospital De La Santa Creu I Sant Pau
  - Barcelona, Spanien, 08035
    - Hospital Universitari Vall d'Hebron
  - Barcelona, Spanien, 08023
    - Hospital Quironsalud Barcelona
  - Madrid, Spanien, 28034
    - Hospital Universitario Ramon y Cajal
  - Málaga, Spanien, 29010
    - Hospital Regional Universitario de Malaga
  - Seville, Spanien, 41010
    - Hospital Quironsalud Infanta Luisa
  - Seville, Spanien, 41071
    - Hospital Universitario Virgen Macarena
  - Seville, Spanien, 41003
    - Nuevas Tecnologias en Diabetes y Endocrinologia
- Barcelona
  - Badalona, Barcelona, Spanien, 08916
    - Hospital Universitari Germans Trias i Pujol
- Cádiz
  - Sanlúcar de Barrameda, Cádiz, Spanien, 11540
    - Hospital Virgen del Camino
- Córdoba
  - Córdoba, Córdoba, Spanien, 14004
    - Hospital Universitario Reina Sofia
- La Coruña
  - A Coruña, La Coruña, Spanien, 15006
    - Complejo Hospitalario Universitario A Coruña
  - Santiago de Compostela, La Coruña, Spanien, 15706
    - Complejo Hospitalario Universitario de Santiago
Sydafrika
- Gauteng
  - Alberton, Gauteng, Sydafrika, 1449
    - Cardiology Clinical Research
  - Centurion, Gauteng, Sydafrika, 0157
    - Johese Clinical Research: Unitas
  - Johannesburg, Gauteng, Sydafrika, 2013
    - WITS Clinical Research
  - Johannesburg, Gauteng, Sydafrika, 1827
    - Lenasia Clinical Trial Centre
  - Johannesburg, Gauteng, Sydafrika, 1724
    - Medicross Roodepoort Clinical Research
  - Kempton Park, Gauteng, Sydafrika, 1619
    - Clinresco Centres (Pty) Ltd
  - Mamelodi East, Gauteng, Sydafrika, 0122
    - Synexus SA - Stanza Clinical Research Centre
  - Pretoria, Gauteng, Sydafrika, 0084
    - Emmed Research
  - Pretoria, Gauteng, Sydafrika, 0002
    - Seeber, M
  - Pretoria, Gauteng, Sydafrika, 0184
    - Synexus SA Watermeyer Clinical Research Centre
  - Pretoria, Gauteng, Sydafrika, 1692
    - Johese Clinical Research: Midstream
- Limpopo
  - Thabazimbi, Limpopo, Sydafrika, 0380
    - Limpopo Clinical Research Initiative
- Mpumalanga
  - Moloto South, Mpumalanga, Sydafrika, 1022
    - Dr AA Mahomed Medical Centre
- Western Cape
  - Cape Town, Western Cape, Sydafrika, 7530
    - Tiervlei Trial Centre
  - Cape Town, Western Cape, Sydafrika, 7130
    - Synexus Helderberg Clinical Research Centre
  - Cape Town, Western Cape, Sydafrika, 7500
    - Corbod Research
  - Cape Town, Western Cape, Sydafrika, 7500
    - Tread Research
  - Cape Town, Western Cape, Sydafrika, 7580
    - Cape Town Medical Research Centre
  - Cape Town, Western Cape, Sydafrika, 7646
    - Paarl Research Centre
  - Cape Town, Western Cape, Sydafrika, 7925
    - Groote Schuur Hospital Lipid Laboratory
  - Somerset West, Western Cape, Sydafrika, 7130
    - Dr JM Engelbrecht Practice
  - Somerset West, Western Cape, Sydafrika, 7130
    - Helderberg Research Institute
Tjekkiet
- - Beroun, Tjekkiet, 266 01
    - Medicentrum Beroun spol. s.r.o.
  - Brno, Tjekkiet, 65691
    - Fakultni Nemocnice u sv. Anny v Brne
  - Brno, Tjekkiet, 639 00
    - Nemocnice Milosrdnych bratri
  - Broumov, Tjekkiet, 550 01
    - Edumed s.r.o
  - Choceň, Tjekkiet, 56501
    - Poliklinika Chocen a.s.
  - Chomutov, Tjekkiet, 430 02
    - Ordinace pro choroby srdce s.r.o.
  - Chrudim, Tjekkiet, 537 01
    - MUDr. Jan Hubac s.r.o.
  - Havlíčkův Brod, Tjekkiet, 580 22
    - Nemocnice Havlickuv Brod p.o.
  - Hradec Králové, Tjekkiet, 500 02
    - Kardio-Pisova s.r.o.
  - Krnov, Tjekkiet, 794 01
    - MUDr. Tomas Edelsberger
  - Náchod, Tjekkiet, 547 01
    - Edumed s.r.o
  - Olomouc, Tjekkiet, 772 00
    - Agentura Science Pro Spol. s.r.o.
  - Olomouc, Tjekkiet, 77900
    - PreventaMed s.r.o.
  - Ostrava, Tjekkiet, 702 00
    - CCR Ostrava s.r.o.
  - Prague, Tjekkiet, 120 00
    - Synexus Czech s.r.o.
  - Prague, Tjekkiet, 158 00
    - Corintez s.r.o.
  - Prague, Tjekkiet, 128 00
    - Vseobecna fakultni nemocnice v Praze
  - Prague, Tjekkiet, 101 00
    - MUDr. Jan KVASNICKA CSc. Angiologie kardiologie a interna
  - Prague, Tjekkiet, 110 00
    - Nemocnice Na Frantisku
  - Prague, Tjekkiet, 18100
    - ResTrial s.r.o.
  - Rakovník, Tjekkiet, 269 01
    - MUDr.Eva Mandakova MBA
  - Slaný, Tjekkiet, 274 01
    - Nemocnice Slany
  - Teplice, Tjekkiet, 415 01
    - AeskuLab k.s.
  - Trutnov, Tjekkiet, 541 01
    - Kardiologicka ambulance MUDr. Ferkl s.r.o.
  - Uherské Hradiště, Tjekkiet, 68601
    - Clinical Trials Services s.r.o
  - Uherské Hradiště, Tjekkiet, 68601
    - MUDr. Nina Zemkova s.r.o.
Tyskland
- - Berlin, Tyskland, 10409
    - Diabetespraxis Prenzlauer Allee
  - Berlin, Tyskland, 12627
    - Synexus Clinical Research GmbH
  - Berlin, Tyskland, 10437
    - Institut fuer klinische Forschung und Entwicklung Berlin GmbH
  - Berlin, Tyskland, 10789
    - Studienzentrum Rankestrasse
  - Hamburg, Tyskland, 22607
    - Gemeinschaftspraxis fuer innere Medizin und Diabetologie
- Baden-Wurttemberg
  - Freiburg im Breisgau, Baden-Wurttemberg, Tyskland, 79106
    - Universitaetsklinikum Freiburg
  - Villingen-Schwenningen, Baden-Wurttemberg, Tyskland, 78048
    - Praxis fuer Praevention und Therapie
- Bavaria
  - Künzing, Bavaria, Tyskland, 94550
    - Gemeinschaftspraxis Dr. Klein/ Minnich
  - Munich, Bavaria, Tyskland, 80636
    - Deutsches Herzzentrum Muenchen
  - Munich, Bavaria, Tyskland, 80336
    - Klinikum der Universitaet Muenchen
  - Naumburg, Bavaria, Tyskland, 90402
    - GP Dr. Haggenmiller, PD Dr. Michael Jeserich
- Brandenburg
  - Elsterwerda, Brandenburg, Tyskland, 04910
    - ZKS-Südbrandenburg -center for clinical studies Südbrandenburg GmbH
- Hesse
  - Bad Homburg, Hesse, Tyskland, 61348
    - Neurologische Praxis Dr. Schoell & Kollegen
  - Frankfurt am Main, Hesse, Tyskland, 60313
    - Synexus Clinical Research GmbH
  - Frankfurt am Main, Hesse, Tyskland, 60596
    - ClinPhenomics GmbH & Co KG
- Mecklenburg-Vorpommern
  - Schwerin, Mecklenburg-Vorpommern, Tyskland, 19055
    - Klinische Forschung Schwerin GmbH
- North Rhine-Westphalia
  - Bochum, North Rhine-Westphalia, Tyskland, 44787
    - Synexus Clinical Research GmbH
  - Dortmund, North Rhine-Westphalia, Tyskland, 44137
    - St. Johannes Hospital
  - Dortmund, North Rhine-Westphalia, Tyskland, 44137
    - Gemeinschaftspraxis Diabeteszentrum Dortmund Dr.med. Klaus Busch
  - Dortmund, North Rhine-Westphalia, Tyskland, 44137
    - Kardiologische Praxis Gemeinschaftspraxis
  - Dortmund, North Rhine-Westphalia, Tyskland, 44139
    - Klinikum Bielefeld gem. GmbH
  - Siegen, North Rhine-Westphalia, Tyskland, 57072
    - Zentrum fuer Praevention und Rehabilitation
- Saxony
  - Leipzig, Saxony, Tyskland, 04103
    - Synexus Clinical Research GmbH
  - Leipzig, Saxony, Tyskland, 04249
    - Gemeinschaftspraxis Dr. Taeschner / Dr. Bonigut
- Schleswig-Holstein
  - Neumünster, Schleswig-Holstein, Tyskland, 24534
    - Dr. Uwe Böckmann / Birgit Jacobs - Diabeteszentrum Neumünster
  - Oldenburg in Holstein, Schleswig-Holstein, Tyskland, 23758
    - RED - Institut GmbH
- Thuringia
  - Erfurt, Thuringia, Tyskland, 99097
    - Katholisches Krankenhaus "St. Johann Nepomuk"
Ukraine
- - Cherkasy, Ukraine, 18009
    - Cherkasy Regional Cardiological Center
  - Cherkasy, Ukraine, 18009
    - CI Cherkasy RH of Cherkasy Regional Council
  - Chernivtsi, Ukraine, 58000
    - CMI CCH#3 Dep of Ther# w the beds of card profile HSEI of UBSMU
  - Chernivtsi, Ukraine, 58022
    - RCI Chernivtsi Regional Endocrinology Center Policlinic Dept SHEI of UBSMU
  - Dnipro, Ukraine, 49038
    - Medical Center of Limited Liability Company Medical Center Clinic of Family Medicine
  - Dnipro, Ukraine, 49000
    - CI Dnipropetrovsk City Cl Hosp #9 of Dniprop Reg Council SI DMA of MOH of Ukr Ch of Endocrinology
  - Ivano-Frankivsk, Ukraine, 76008
    - Regional CH Dept of Endocrinology SHEI Ivano-Frankivsk NMU
  - Ivano-Frankivsk, Ukraine, 76018
    - CI Ivano-Frankivsk Reg Cl Card Center Dept of Chronic Ischemic Heart Dis SHEI Ivano-Frank NMU
  - Ivano-Frankivsk, Ukraine, 76018
    - Ivano-Frankivsk CCH Dept of Therapy #1 SHEI Ivano-Frankivsk NMU
  - Kharkiv, Ukraine, 61039
    - GI L.T.Malaya Therapy National Institute of the NAMS of Ukraine
  - Kharkiv, Ukraine, 61103
    - Railway Transport Kharkiv CH#1 of Healthcare Center Branch of PJSC Ukrainian Railway
  - Kharkiv, Ukraine, 61002
    - CHI Kharkiv City Student Hosp Therap dept Nat Pharm Univer
  - Kharkiv, Ukraine, 61037
    - CNE Prof. O.O. Shalimov Kharkiv City Clinical Hospital #2 KCC
  - Kharkiv, Ukraine, 61039
    - State Institution LT Malaya Inst. of Ther. of AMS of Ukraine
  - Kharkiv, Ukraine, 61103
    - Railway Transport Kharkiv CH #1 of Healthcare Center Branch of PJSC Ukr Railway
  - Kharkiv, Ukraine, 61106
    - MC Doctor Alex Dept of General Practice-Family Medicine Kharkiv MA of PGE
  - Kharkiv, Ukraine, 61176
    - CNE City Clin Hosp #8 of KCC Dept of Therapy Kharkiv MA of PGE of MOHU
  - Kherson, Ukraine, 73000
    - CI Ye.Ye.Karabelesh Kherson City Clinical Hosp.
  - Kyiv, Ukraine, 03049
    - Kyiv CH on Railway Transport #2 of Branch Center of Healthcare Public Company Ukr Railway
  - Kyiv, Ukraine, 03680
    - SI NSC M.D. Strazhesko Institute of Cardiology of NAMSU
  - Kyiv, Ukraine, 01103
    - Kyiv CCH #12 Dept of Therapy O.O.Bogomolets NMU
  - Kyiv, Ukraine, 04050
    - Medical Center of Limited Liability Company Medical Center Concilium Medical
  - Kyiv, Ukraine, 02002
    - LLC Treatment and Diagnostic Center Adonis Plus
  - Kyiv, Ukraine, 01004
    - KCCC of Endocr Dept of General Endocrine Pathology O. O. Bogomolets NMU
  - Kyiv, Ukraine, 02002
    - MC of PHEI Institute of General Practice - Family Medicine
  - Kyiv, Ukraine, 02081
    - Medical Center Blagomed Plus LLC
  - Kyiv, Ukraine, 02091
    - Med Center 'Ok!Clinic+' of International Institute of Clinical Trials LLC
  - Kyiv, Ukraine, 03037
    - MC of Subsidiary Production Unit Med Scient Pract Union Medbud of PJSc Holding Company Kyivmiskbud
  - Kyiv, Ukraine, 03110
    - Med Center of Eurolab LLC Policlinic Outpatient Dept O.O.Bogomolets NMU
  - Kyiv, Ukraine, 03115
    - SI National Scientific Centre of Radiation Medicine of NAMSU
  - Kyiv, Ukraine, 03680
    - SI NSС M.D. Strazhesko Institute of Cardiology of NAMSU
  - Kyiv, Ukraine, 04050
    - Department of Medical Services and Rehabilitation of State Joint Stock Holding Company Artem
  - Kyiv, Ukraine, 04053
    - CI of Kyiv RC Regional Clinical Hospital #2
  - Kyiv, Ukraine, 04114
    - SI V.P.Komisarenko Institute of E&M of NAMSU
  - Kyiv, Ukraine, 04114
    - SI V.P.Komisarenko Institute of Endocrinology and Metabolism of NAMSU
  - Lviv, Ukraine, 79010
    - Lviv Reg St Clin Treatment - Diagnostic Endocrin Center, Dept of Polyclinic, D.Galytskyy Lviv NMU
  - Lviv, Ukraine, 79011
    - Lviv Communal 4th City Clinical Hospital
  - Odesa, Ukraine, 65000
    - Center of Reconstructive & Restorative Medicine (University Clinic) of Odessa National Medical Uni
  - Sumy, Ukraine, 40021
    - CI Sumy City Clinical Hospital #1 Dept of Therapy Sumy SU Med Inst
  - Ternopil, Ukraine, 46023
    - Ternopil City Municipal Hospital #2 Dept of Gastroenterology Ternopil I.Ya. Gorbachevskyi SMU
  - Uzhhorod, Ukraine, 88014
    - Transcarpathian Regional Clinical Cardiology Dispansery
  - Vinnytsia, Ukraine, 21018
    - National Pirogov Memorial Medical University
  - Vinnytsia, Ukraine, 21029
    - SRI of Invalid Rehabilitation (EST Complex) of Vinnytsia M.I.Pyrogov NMU MOHU
  - Vinnytsia, Ukraine, 21001
    - Private Small Enterprise Medical Center Pulse
  - Vinnytsia, Ukraine, 21010
    - Vinnytsia RC Highly Special.Endocr.Center Dept of Therapy #2 M.I. Pyrogov NMU
  - Zaporizhzhia, Ukraine, 69001
    - CI Zapor CCH#10 SI ZMA PGE Ch of therapy clin pharmacol & endocrin
  - Zhytomyr, Ukraine, 10002
    - Zhytomyr regional clinical hospital n.a. O.F. Gerbachevskyy
  - Zhytomyr, Ukraine, 10002
    - CI Central City Hospital #1 of Zhytomyr
Ungarn
- - Baja, Ungarn, 6500
    - Principal SMO Kft.
  - Baja, Ungarn, 6500
    - Lausmed Kft.
  - Balatonfüred, Ungarn, 8230
    - DRC Gyogyszervizsgalo Kozpont Kft.
  - Budapest, Ungarn, 1083
    - Semmelweis Egyetem
  - Budapest, Ungarn, 1033
    - Clinexpert Kft.
  - Budapest, Ungarn, 1036
    - Synexus Magyarorszag Kft.
  - Budapest, Ungarn, 1083
    - CSALADGYOGYASZ Kft.
  - Békéscsaba, Ungarn, 5600
    - Békés Megyei Központi Kórház Dr. Réthy Pál Tagkórház
  - Békéscsaba, Ungarn, 5600
    - Belgyogyaszati es Kardiologiai Maganrendelo
  - Debrecen, Ungarn, 4032
    - Debreceni Egyetem
  - Debrecen, Ungarn, 4025
    - Borvo Clinic Kft.
  - Gyula, Ungarn, 5700
    - Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaza
  - Gyula, Ungarn, 5700
    - Synexus Magyarorszag Egeszsegugyi Szolgaltato Kft.- Gyula DRS
  - Gödöllő, Ungarn, 2100
    - Meditoll Kft.
  - Hatvan, Ungarn, 3000
    - BKS Research Kft.
  - Kalocsa, Ungarn, 6300
    - Z+P MED Egeszsegugyi, Kereskedelmi es Szolgaltato Bt.
  - Kaposvár, Ungarn, 7400
    - Somogy Megyei Kaposi Mor Oktato Korhaz
  - Komárom, Ungarn, 2900
    - Selye János Kórház
  - Miskolc, Ungarn, 3530
    - IPR Hungary Kft.
  - Nagykanizsa, Ungarn, 8800
    - Kanizsai Dorottya Korhaz
  - Nyíregyháza, Ungarn, 4400
    - Medifarma-98 Kft.
  - Nyíregyháza, Ungarn, H-4405
    - BORBANYA PRAXIS Kft.
  - Orosháza, Ungarn, 5900
    - Dr. Nagy Laszlo Kardiologiai Maganrendeles
  - Pécs, Ungarn, 7635
    - Da Vinci Magánklinika
  - Szekszárd, Ungarn, 7100
    - Tolna Megyei Balassa János Kórház
  - Székesfehérvár, Ungarn, 8000
    - Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz
  - Veszprém, Ungarn, 8200
    - Csolnoky Ferenc Korhaz
  - Zalaegerszeg, Ungarn, 8900
    - Zala Megyei Szent Rafael Korhaz

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

14 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Beskrivelse

Inklusionskriterier:

Fastende TG ≥ 200 mg/dL (2,26 mmol/L) og < 500 mg/dL (5,65 mmol/L) ved besøg 1 (screening/tilmeldingsbesøg) eller besøg 1.1 (gentest)
HDL-C ≤ 40 mg/dL (1,03 mmol/L) ved besøg 1 (screening/tilmeldingsbesøg) eller besøg 1.1 (gentest)
Type 2-diabetes af længere varighed end 12 uger dokumenteret i journaler, for eksempel: lokal laboratoriebevis gennem journalgennemgang af forhøjet HbA1c (≥ 6,5 % [48 mmol/mol]), forhøjet plasmaglukose (fastende ≥ 126 mg/dL [ 7,0 mmol/L], 2 timer ≥ 200 mg/dL [11,1 mmol/L] under oral glukosetolerancetest, eller tilfældig værdi ≥ 200 mg/dL med klassiske symptomer, eller i øjeblikket tager medicin til behandling af diabetes; OG enten
1. Alder ≥ 50 år, hvis mand eller ≥ 55 år, hvis kvinde (primær forebyggelseskohorte); ELLER
2. Alder ≥ 18 år og etableret systemisk aterosklerose (sekundær forebyggelseskohorte), defineret som en af følgende:
  - jeg. Tidligere MI eller iskæmisk (ikke-hæmoragisk) slagtilfælde
  - ii. Koronar angiografisk læsion af ≥ 60 % stenose i et større epikardiekar eller ≥ 50 % venstre hovedstenose
  - iii. Asymptomatisk carotissygdom med ≥ 70 % carotisarteriestenose
  - iv. Symptomatisk carotissygdom med ≥ 50 % carotisarteriestenose
  - v. Symptomatisk PAD i nedre ekstremiteter (dvs. claudicatio intermittens, hvilesmerter, iskæmisk ulceration i nedre ekstremiteter eller større amputation med enten ankel-brachial indeks ≤ 0,9 eller anden diagnostisk test [f.eks. tå-brachial indeks, angiogram eller anden billeddiagnostik undersøgelse] )
  - vi. Forudgående arteriel revaskulariseringsprocedure (herunder koronar-, carotis- eller perifer angioplastik/stenting, bypass eller aterektomi/endarterektomi)

Ekskluderingskriterier:

Aktuel eller planlagt brug af fibrater eller midler med PPAR-α-agonistaktivitet (f.eks. saroglitazar) inden for 6 uger (42 dage) efter besøg 1 (screenings-/tilmeldingsbesøg). Bemærk: PPAR-γ-agonister (f.eks. glizatoner som pioglitazon og rosiglitazon) er tilladt
Kendt følsomhed over for PPAR-α-agonister eller tablet-hjælpestoffer
Påbegyndelse af eller ændring i nuværende TG-sænkende behandling inden for 12 uger efter besøg 1 (hvis relevant). Bemærk: TG-sænkende behandling er defineret som niacin > 100 mg/dag eller kosttilskud eller receptpligtige omega-3 fedtsyrer > 1 g/dag
Type 1 diabetes mellitus

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Forebyggelse
Tildeling: Randomiseret
Interventionel model: Parallel tildeling
Maskning: Firedobbelt

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Eksperimentel: Behandlingsgruppe K-877 (pemafibrat) tablet to gange dagligt.	Medicin: K-877 0,2 mg tablet Andre navne: pemafibrat
Placebo komparator: Kontrolgruppe Matchende K-877 placebotablet to gange dagligt.	Medicin: Placebo K-877 matchende placebotablet

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Antal deltagere med første forekomst af 4-komponentkomposit primært slutpunkt (ikke-dødelig MI, ikke-dødelig iskæmisk slagtilfælde, koronar revaskularisering eller CV-død) Tidsramme: Fra baseline til en median på 3,3 år	Antal deltagere, der oplever deres første forekomst af enhver komponent af 4-komponentens sammensatte primære endepunkt, som inkluderer ikke-dødelig myokardieinfarkt (MI), ikke-dødelig iskæmisk slagtilfælde, koronar revaskularisering eller kardiovaskulær (CV) død. Hver deltager tælles kun én gang, uanset efterfølgende begivenheder.	Fra baseline til en median på 3,3 år

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Antal deltagere med første forekomst af 4-komponentkomposit sekundært slutpunkt (ikke-dødelig MI, ikke-dødelig iskæmisk slagtilfælde, indlæggelse for ustabil angina, der kræver uplanlagt koronar revaskularisering eller CV-død) Tidsramme: Fra baseline til en median på 3,3 år	De 4-komponentkomposite sekundære endepunkter Begivenheder er ikke-dødelig myokardieinfarkt, ikke-dødelig iskæmisk slagtilfælde, indlæggelse for ustabil angina, der kræver ikke-planlagt koronar revaskularisering eller kardiovaskulær død	Fra baseline til en median på 3,3 år
Antal deltagere med første forekomst af 3-komponentens sammensatte slutpunkt (ikke-dødelig myokardieinfarkt, ikke-dødelig iskæmisk slagtilfælde eller kardiovaskulær død) Tidsramme: Fra baseline til en median på 3,3 år	Antal deltagere med første forekomst af sammensatte kardiovaskulære begivenheder (ikke -dødelig myokardieinfarkt, ikke -dødelig iskæmisk slagtilfælde eller kardiovaskulær død)	Fra baseline til en median på 3,3 år
Antal deltagere med første forekomst af enhver komponent i det primære slutpunkt eller hospitalisering for hjertesvigt Tidsramme: Fra baseline til en median på 3,3 år	Begivenhed er den første forekomst af enhver komponent i det sammensatte slutpunkt for ikke -dødelig myokardieinfarkt, ikke -dødelig iskæmisk slagtilfælde, koronar revaskularisering, hjerte -kar -død eller hospitalisering af hjertesvigt	Fra baseline til en median på 3,3 år
Antal deltagere med forekomst af enhver komponent i det primære endepunkt eller dødelighed af al årsag Tidsramme: Fra baseline til en median på 3,3 år	Begivenhed er den første forekomst af enhver komponent i det sammensatte endepunkt for ikke-dødelig myokardieinfarkt, ikke-dødelig iskæmisk slagtilfælde, koronar revaskularisering, hjerte-kar-død eller dødelighed af al årsag.	Fra baseline til en median på 3,3 år
Samlet antal begivenheder i 4-komponentkomposit primært slutpunkt Tidsramme: Fra baseline til en median på 3,3 år	Det samlede antal begivenheder for 4-komponentens sammensatte primære slutpunkt, der tæller alle forekomster, inklusive flere begivenheder i den samme deltager. Endpoint -begivenhederne inkluderer ikke -dødelig myokardieinfarkt (MI), ikke -dødelig iskæmisk slagtilfælde, koronar revaskularisering og kardiovaskulær (CV) død.	Fra baseline til en median på 3,3 år
Antal deltagere med første forekomst af enhver ny eller forværring af perifer arteriesygdom (PAD) Tidsramme: Fra baseline til en median på 3,3 år	Enhver ny eller forværring af perifer arteriesygdom (PAD), defineret som forekomst af revaskularisering af nedre ekstremitet, intermitterende claudication, hvilesmerter, iskæmisk mavesår eller større amputation med enten ankel-brachial indeks ≤ 0,9 eller anden diagnostisk test (f.	Fra baseline til en median på 3,3 år
Antal deltagere med første forekomst af ikke -dødelig myokardieinfarkt Tidsramme: Fra baseline til en median på 3,3 år		Fra baseline til en median på 3,3 år
Antal deltagere med første forekomst af ikke -dødelig iskæmisk slagtilfælde Tidsramme: Fra baseline til en median på 3,3 år		Fra baseline til en median på 3,3 år
Antal deltagere med første forekomst af koronar revaskularisering Tidsramme: Fra baseline til en median på 3,3 år		Fra baseline til en median på 3,3 år
Antal deltagere med første forekomst af hjerte -kar -død Tidsramme: Fra baseline til en median på 3,3 år		Fra baseline til en median på 3,3 år
Antal deltagere med første forekomst af 4-komponentens sammensatte endepunkt af PPAR-a-genvariant undergruppe (TT, CT, CC) Tidsramme: Fra baseline til en median på 3,3 år	Antal deltagere, der oplever deres første forekomst af enhver komponent af 4-komponentens sammensatte primære endepunkt (ikke-dødelig myokardieinfarkt, ikke-dødelig iskæmisk slagtilfælde, koronar revaskularisering eller kardiovaskulær død), rapporteret som en undergruppeanalyse af PPAR-a-genvarianter (TT, CT, CC).	Fra baseline til en median på 3,3 år
Procentændring fra baseline til måned 4 for total kolesterol (TC) Tidsramme: Baseline til måned 4		Baseline til måned 4
Procentændring fra baseline til måned 4 for faste triglycerider Tidsramme: Baseline til 4 måneder		Baseline til 4 måneder
Procentændring fra baseline til måned 4 for HDL - kolesterol (HDL -C) Tidsramme: Baseline til måned 4		Baseline til måned 4
Procentændring fra baseline til måned 4 for beregnet ikke-HDL-kolesterol (ikke-HDL-C) Tidsramme: Baseline til måned 4		Baseline til måned 4
Procentændring fra baseline til måned 4 for beregnet VLDL -kolesterol Tidsramme: Baseline til måned 4		Baseline til måned 4
Procentændring fra baseline til måned 4 for apolipoprotein A1 (APOA1) Tidsramme: Baseline til måned 4		Baseline til måned 4
Procentændring fra baseline til måned 4 for apolipoprotein CIII (APOC3) Tidsramme: Baseline til måned 4		Baseline til måned 4
Procentændring fra baseline til måned 4 for apolipoprotein E (Apoe) Tidsramme: Baseline til måned 4		Baseline til måned 4
Procentændring fra baseline til måned 6 for ikke-fast resterende kolesterol Tidsramme: Baseline til måned 6		Baseline til måned 6

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Kowa Research Institute, Inc.

Samarbejdspartnere

Brigham and Women's Hospital

Efterforskere

Studieleder: Paul Ridker, MD, CCVDP & The Brigham and Women's Hospital
Studieleder: Aruna Pradhan, MD, CCVDP & The Brigham and Women's Hospital

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

23. marts 2017

Primær færdiggørelse (Faktiske)

27. juli 2022

Studieafslutning (Faktiske)

27. juli 2022

Datoer for studieregistrering

Først indsendt

23. februar 2017

Først indsendt, der opfyldte QC-kriterier

1. marts 2017

Først opslået (Faktiske)

7. marts 2017

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Anslået)

25. september 2025

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

5. september 2025

Sidst verificeret

1. september 2025

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

K-877-302

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

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Kliniske forsøg med K-877

Kowa Research Institute, Inc.

Afsluttet

Undersøgelse for at undersøge effektiviteten og den farmakokinetiske profil af K-877-ER sammenlignet med K-877-IR

Dyslipidæmi

Forenede Stater
Kowa Research Institute, Inc.

Afsluttet

Sammenlign farmakokinetikken af K-877-tabletter med kontrolleret frigivelse (CR) og øjeblikkelig frigivelse (IR) hos raske voksne.

Sund og rask

Forenede Stater
Kowa Research Institute, Inc.

Afsluttet

Undersøgelse for at vurdere fødevareeffekten af K-877 hos raske voksne frivillige

Sund og rask

Forenede Stater
Kowa Company, Ltd.

Afsluttet

En klinisk farmakologisk undersøgelse af K-877-tablet med kontrolleret frigivelse

Dyslipidæmi

Japan
Kowa Company, Ltd.

Afsluttet

En undersøgelse af pemafibrat hos patienter med ikke-alkoholisk fedtleversygdom (NAFLD)

Ikke-alkoholisk fedtleversygdom

Japan
Kowa Research Institute, Inc.

Afsluttet

Undersøgelse for at evaluere effektiviteten og sikkerheden af K-877 hos voksne patienter med fastende høje triglyceridniveauer og let eller moderat nedsat nyrefunktion

Alvorlig hypertriglyceridæmi

Forenede Stater, Tjekkiet, Hviderusland, Ungarn, Den Russiske Føderation, Polen, Bulgarien, Georgien, Ukraine
Kowa Research Institute, Inc.

Afsluttet

Lægemiddel-lægemiddelinteraktionsundersøgelse for at vurdere virkningerne af multiple-dosis administration af K-877 på farmakodynamikken og farmakokinetikken af multiple-dosis administration af warfarin hos raske voksne frivillige

Sund og rask

Forenede Stater
Kowa Research Institute, Inc.

Afsluttet

Undersøgelse for at evaluere effektiviteten og sikkerheden af K-877 hos voksne patienter med fastende høje triglyceridniveauer og normal nyrefunktion

Alvorlig hypertriglyceridæmi

Forenede Stater, Ungarn, Hviderusland, Bulgarien, Tjekkiet, Georgien, Polen, Den Russiske Føderation, Ukraine
Kowa Company, Ltd.

Afsluttet

Et bekræftende fase III-studie af K-877 Extended Release-tablet

Dyslipidæmi

Japan
Kowa Research Institute, Inc.

Afsluttet

Et grundigt korrigeret QT-intervalforsøg

Dyslipidæmi

Forenede Stater

Pemafibrat for at reducere kardiovaskulære resultater ved at reducere triglycerider HOS patienter med diabetes (PROMINENT) (PROMINENT)

Studieoversigt

Status

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsestype

Tilmelding (Faktiske)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Samarbejdspartnere

Efterforskere

Publikationer og nyttige links

Generelle publikationer

Datoer for undersøgelser

Studer store datoer

Studiestart (Faktiske)

Primær færdiggørelse (Faktiske)

Studieafslutning (Faktiske)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Faktiske)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Anslået)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Studerer et amerikansk FDA-reguleret enhedsprodukt

Kliniske forsøg med K-877

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Hungary

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer