- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03280823
Effect of Platelet Storage on Complement Activation
Study Overview
Status
Conditions
Detailed Description
Ten units of platelets will be selected from the regular inventory of the Central Blood Transfusion Services/Assiut University Hospitals . All units of platelets will be collected, processed, and tested following the standard procedures.
Thesis units will be stored on a platelet rotator with the temperature controlled between 22 and 24c. Samples will be obtained using a sterile technique .
The investigators will take basal sample and samples on day 2,3,4 and 5. Complement components will be assayed : C4 (classical pathway), C3 (common pathway) and C5 (terminal pathway).
This evaluation will be done using ELISA technique
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: Shimaa A Ahmed
- Phone Number: 01065952778
- Email: shimaaabdeleem11@gmail.com
Study Contact Backup
- Name: Maha A Mahmoud
- Phone Number: 01000004572
- Email: atwa-maha@yahoo.com
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
No Use of aspirin or non steroidal anti-inflammatory drugs or medication affecting the platelets.
Negative screening and confirmatory tests will be done for all platelet donors
Description
Inclusion Criteria:
- Negative screening and confirmatory tests will be done for all platelet donors
Exclusion Criteria:
- Use of aspirin or non steroidal anti-inflammatory drugs or medication affecting the platelets.
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Platelets can be used after storage upto 5 days instead of using in the same day of donation without complement activation.
Time Frame: 5 days
|
5 days
|
Collaborators and Investigators
Sponsor
Publications and helpful links
Study record dates
Study Major Dates
Study Start (Anticipated)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- platelets and complement
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Platelet Storage
-
Assiut UniversityNot yet recruitingPlatelet Storage Lesion(PSL)
-
Assiut UniversityNot yet recruitingPlatelet Storage Pool Deficiency
-
Duke UniversityKriya TherapeuticsRecruitingGlycogen Storage Disease VI | GLYCOGEN STORAGE DISEASE IXa1 | GLYCOGEN STORAGE DISEASE IXa2 | Glycogen Storage Disease IXB | Glycogen Storage Disease IXC | GSD 9 (All Subtypes) | GSD 6United States
-
HOSPITAL BRITANICO DE BUENOS AIRESRecruitingPlatelet Cryopreservation | Platelet SurvivalArgentina
-
Centre Hospitalier Universitaire, AmiensRecruitingPlatelet Aggregation | Heparin-induced Thrombocytopenia | Platelet Activation | Platelet DisorderFrance
-
CENTOGENE GmbH RostockWithdrawnFructose Metabolism, Inborn Errors | Glycogen Storage Disease Type II | Glycogen Storage Disease | Glycogen Storage Disease Type V | Glycogen Storage Disease Type I | Glycogen Storage Disease Type III | Glycogen Storage Disease Type VII | Glycogen Storage Disease Type IV | Glycogen Storage Disease Type... and other conditionsGermany, India, Sri Lanka
-
The First Affiliated Hospital of Soochow UniversityRecruiting
-
Aarhus University HospitalUniversity of AarhusCompletedExtracorporeal Membrane Oxygenation | Platelet Aggregation | Platelet Activation | Intensive Care Units | Blood Platelets | Platelet Function TestsDenmark
-
University Medical Center GroningenUltragenyx Pharmaceutical IncCompletedGlycogen Storage Disease Type IANetherlands
-
University Hospital, GenevaCompletedAcquired Platelet DisorderSwitzerland