Cisplatin/Carboplatin and Etoposide With or Without Nivolumab in Treating Patients With Extensive Stage Small Cell Lung Cancer
April 3, 2024 updated by: National Cancer Institute (NCI)
Randomized Phase II Clinical Trial of Cisplatin/Carboplatin and Etoposide (CE) Alone or in Combination With Nivolumab as Frontline Therapy for Extensive Stage Small Cell Lung Cancer (ED-SCLC)
This randomized phase II clinical trial studies whether the addition of nivolumab to cisplatin (or carboplatin) and etoposide will improve outcomes when treating patients with extensive stage small cell lung cancer.
Chemotherapy drugs, such as cisplatin, carboplatin, and etoposide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.
Giving cisplatin/carboplatin and etoposide together with nivolumab may work better in treating patients with extensive stage small cell lung cancer.
Study Overview
Status
Active, not recruiting
Intervention / Treatment
Detailed Description
PRIMARY OBJECTIVE:
I. To evaluate the progression-free survival (PFS) of patients with extensive stage small cell lung cancer (ED-SCLC) treated with cisplatin/carboplatin and etoposide (CE) or CE with nivolumab (CEN) as front-line treatment.
SECONDARY OBJECTIVES:
I. To estimate overall survival of patients with ED-SCLC treated with cisplatin/carboplatin and etoposide (CE) or CE with nivolumab (CEN) as front-line treatment.
II. To assess best overall response rate after treatment with CE with or without nivolumab as first line treatment.
III. To evaluate the toxicity profile of nivolumab with CE.
EXPLORATORY OBJECTIVES:
I. To evaluate immune biomarkers and biomarkers correlatives. II. To evaluate serial circulating tumor deoxyribonucleic acid (DNA) and explore whether clinical outcome is associated with fluctuations in DNA levels following the administration of therapy.
OUTLINE: Patients are randomized to 1 of 2 arms.
ARM A: Patients receive nivolumab intravenously (IV) over 30 minutes on day 1, carboplatin IV over 30-60 minutes on day 1 or cisplatin IV over 60-120 minutes on day 1, and etoposide IV over 60-120 minutes on days 1-3. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Patients continue to receive nivolumab IV over 30 minutes every 2 weeks for up to 2 years.
ARM B: Patients receive carboplatin IV over 30-60 minutes on day 1 or cisplatin IV over 60-120 minutes on day 1, and etoposide IV over 60-120 minutes on days 1-3. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 3 months if the patient is less than 2 years from registration, every 6 months if the patient is 2-3 years from registration, and yearly for up to 5 years from study enrollment.
Study Type
Interventional
Enrollment (Actual)
160
Phase
- Phase 2
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Alaska
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Anchorage, Alaska, United States, 98508
- Anchorage Associates in Radiation Medicine
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Anchorage, Alaska, United States, 99508
- Alaska Breast Care and Surgery LLC
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Anchorage, Alaska, United States, 99508
- Alaska Oncology and Hematology LLC
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Anchorage, Alaska, United States, 99508
- Alaska Women's Cancer Care
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Anchorage, Alaska, United States, 99508
- Anchorage Oncology Centre
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Anchorage, Alaska, United States, 99508
- Katmai Oncology Group
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Anchorage, Alaska, United States, 99508
- Providence Alaska Medical Center
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Anchorage, Alaska, United States, 99504
- Anchorage Radiation Therapy Center
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Arkansas
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Hot Springs, Arkansas, United States, 71913
- CHI Saint Vincent Cancer Center Hot Springs
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California
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Anaheim, California, United States, 92806
- Kaiser Permanente-Anaheim
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Antioch, California, United States, 94531
- Kaiser Permanente-Deer Valley Medical Center
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Arroyo Grande, California, United States, 93420
- PCR Oncology
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Baldwin Park, California, United States, 91706
- Kaiser Permanente-Baldwin Park
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Bellflower, California, United States, 90706
- Kaiser Permanente-Bellflower
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Burbank, California, United States, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Fontana, California, United States, 92335
- Kaiser Permanente-Fontana
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Fresno, California, United States, 93720
- Fresno Cancer Center
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Harbor City, California, United States, 90710
- Kaiser Permanente - Harbor City
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Irvine, California, United States, 92618
- Kaiser Permanente-Irvine
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Los Angeles, California, United States, 90027
- Kaiser Permanente Los Angeles Medical Center
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Los Angeles, California, United States, 90034
- Kaiser Permanente West Los Angeles
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Oakland, California, United States, 94611
- Kaiser Permanente Oakland-Broadway
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Ontario, California, United States, 91761
- Kaiser Permanente-Ontario
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Panorama City, California, United States, 91402
- Kaiser Permanente - Panorama City
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Rancho Cordova, California, United States, 95670
- Kaiser Permanente-Rancho Cordova Cancer Center
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Rancho Mirage, California, United States, 92270
- Eisenhower Medical Center
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Redwood City, California, United States, 94063
- Kaiser Permanente-Redwood City
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Richmond, California, United States, 94801
- Kaiser Permanente-Richmond
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Riverside, California, United States, 92505
- Kaiser Permanente-Riverside
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Rohnert Park, California, United States, 94928
- Rohnert Park Cancer Center
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Roseville, California, United States, 95678
- The Permanente Medical Group-Roseville Radiation Oncology
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Roseville, California, United States, 95661
- Kaiser Permanente-Roseville
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Sacramento, California, United States, 95814
- Kaiser Permanente Downtown Commons
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Sacramento, California, United States, 95823
- Kaiser Permanente-South Sacramento
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Sacramento, California, United States, 95823
- South Sacramento Cancer Center
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Sacramento, California, United States, 95825
- Kaiser Permanente - Sacramento
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San Diego, California, United States, 92120
- Kaiser Permanente-San Diego Zion
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San Diego, California, United States, 92108
- Kaiser Permanente-San Diego Mission
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San Francisco, California, United States, 94115
- Kaiser Permanente-San Francisco
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San Jose, California, United States, 95119
- Kaiser Permanente-Santa Teresa-San Jose
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San Marcos, California, United States, 92078
- Kaiser Permanente-San Marcos
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San Rafael, California, United States, 94903
- Kaiser San Rafael-Gallinas
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San Rafael, California, United States, 94903
- Kaiser Permanente-San Rafael
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Santa Clara, California, United States, 95051
- Kaiser Permanente Medical Center - Santa Clara
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Santa Rosa, California, United States, 95403
- Kaiser Permanente-Santa Rosa
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South San Francisco, California, United States, 94080
- Kaiser Permanente Cancer Treatment Center
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South San Francisco, California, United States, 94080
- Kaiser Permanente-South San Francisco
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Stockton, California, United States, 95210
- Kaiser Permanente-Stockton
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Vacaville, California, United States, 95688
- Kaiser Permanente Medical Center-Vacaville
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Vacaville, California, United States, 95687
- Northbay Cancer Center
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Vallejo, California, United States, 94589
- Kaiser Permanente-Vallejo
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Walnut Creek, California, United States, 94596
- Kaiser Permanente-Walnut Creek
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Woodland Hills, California, United States, 91367
- Kaiser Permanente-Woodland Hills
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Colorado
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Aurora, Colorado, United States, 80012
- Rocky Mountain Cancer Centers-Aurora
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Boulder, Colorado, United States, 80301
- Boulder Community Hospital
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Boulder, Colorado, United States, 80304
- Rocky Mountain Cancer Centers-Boulder
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Colorado Springs, Colorado, United States, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, United States, 80909
- UCHealth Memorial Hospital Central
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Colorado Springs, Colorado, United States, 80907
- Rocky Mountain Cancer Centers-Penrose
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Colorado Springs, Colorado, United States, 80920
- Memorial Hospital North
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Denver, Colorado, United States, 80210
- Porter Adventist Hospital
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Denver, Colorado, United States, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, United States, 80218
- SCL Health Saint Joseph Hospital
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Denver, Colorado, United States, 80220
- Rose Medical Center
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Denver, Colorado, United States, 80218
- Rocky Mountain Cancer Centers-Midtown
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Denver, Colorado, United States, 80220
- Rocky Mountain Cancer Centers-Rose
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Denver, Colorado, United States, 80204
- Denver Health Medical Center
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Denver, Colorado, United States, 80218
- Colorado Blood Cancer Institute
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Denver, Colorado, United States, 80209
- The Women's Imaging Center
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Denver, Colorado, United States, 80206
- National Jewish Health-Main Campus
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Denver, Colorado, United States, 80220
- Western Surgical Care
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Durango, Colorado, United States, 81301
- Mercy Medical Center
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Durango, Colorado, United States, 81301
- Southwest Oncology PC
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Englewood, Colorado, United States, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, United States, 80113
- Swedish Medical Center
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Fort Collins, Colorado, United States, 80524
- Poudre Valley Hospital
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Fort Collins, Colorado, United States, 80528
- Cancer Care and Hematology-Fort Collins
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Golden, Colorado, United States, 80401
- Mountain Blue Cancer Care Center
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Golden, Colorado, United States, 80401
- National Jewish Health-Western Hematology Oncology
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Grand Junction, Colorado, United States, 81501
- Saint Mary's Hospital and Regional Medical Center
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Greeley, Colorado, United States, 80631
- North Colorado Medical Center
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Greeley, Colorado, United States, 80631
- UCHealth Greeley Hospital
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Lafayette, Colorado, United States, 80026
- Good Samaritan Medical Center
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Lakewood, Colorado, United States, 80228
- Saint Anthony Hospital
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Lakewood, Colorado, United States, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Littleton, Colorado, United States, 80120
- Rocky Mountain Cancer Centers-Littleton
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Littleton, Colorado, United States, 80122
- Littleton Adventist Hospital
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Lone Tree, Colorado, United States, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
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Longmont, Colorado, United States, 80501
- Longmont United Hospital
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Longmont, Colorado, United States, 80501
- Rocky Mountain Cancer Centers-Longmont
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Loveland, Colorado, United States, 80539
- McKee Medical Center
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Parker, Colorado, United States, 80138
- Parker Adventist Hospital
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Parker, Colorado, United States, 80138
- Rocky Mountain Cancer Centers-Parker
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Pueblo, Colorado, United States, 81004
- Saint Mary Corwin Medical Center
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Pueblo, Colorado, United States, 81008
- Rocky Mountain Cancer Centers - Pueblo
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Thornton, Colorado, United States, 80260
- Rocky Mountain Cancer Centers-Thornton
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Thornton, Colorado, United States, 80260
- National Jewish Health-Northern Hematology Oncology
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Wheat Ridge, Colorado, United States, 80033
- SCL Health Lutheran Medical Center
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Connecticut
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Middletown, Connecticut, United States, 06457
- Middlesex Hospital
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West Haven, Connecticut, United States, 06516
- Veterans Affairs Connecticut Healthcare System-West Haven Campus
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Delaware
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Dover, Delaware, United States, 19901
- Bayhealth Hospital Kent Campus
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Lewes, Delaware, United States, 19958
- Beebe Medical Center
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Milford, Delaware, United States, 19963
- Bayhealth Hospital Sussex Campus
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Newark, Delaware, United States, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, United States, 19713
- Delaware Clinical and Laboratory Physicians PA
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Newark, Delaware, United States, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, United States, 19718
- Christiana Care Health System-Christiana Hospital
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Rehoboth Beach, Delaware, United States, 19971
- Beebe Health Campus
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Seaford, Delaware, United States, 19973
- TidalHealth Nanticoke / Allen Cancer Center
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Wilmington, Delaware, United States, 19801
- Christiana Care Health System-Wilmington Hospital
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Florida
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Coral Gables, Florida, United States, 33146
- UM Sylvester Comprehensive Cancer Center at Coral Gables
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Deerfield Beach, Florida, United States, 33442
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach
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Fort Lauderdale, Florida, United States, 33316
- Broward Health Medical Center
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Gainesville, Florida, United States, 32610
- University of Florida Health Science Center - Gainesville
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Jacksonville, Florida, United States, 32207
- Baptist MD Anderson Cancer Center
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Lakeland, Florida, United States, 33805
- The Watson Clinic
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Miami, Florida, United States, 33176
- UM Sylvester Comprehensive Cancer Center at Kendall
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Pensacola, Florida, United States, 32504
- Sacred Heart Hospital
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Plantation, Florida, United States, 33324
- UM Sylvester Comprehensive Cancer Center at Plantation
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Weston, Florida, United States, 33331
- Cleveland Clinic-Weston
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Georgia
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Atlanta, Georgia, United States, 30308
- Emory University Hospital Midtown
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Atlanta, Georgia, United States, 30322
- Emory University Hospital/Winship Cancer Institute
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Atlanta, Georgia, United States, 30342
- Emory Saint Joseph's Hospital
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Atlanta, Georgia, United States, 30303
- Grady Health System
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Atlanta, Georgia, United States, 30342
- Northside Hospital
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Cumming, Georgia, United States, 30041
- Northside Hospital-Forsyth
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Decatur, Georgia, United States, 30033
- Atlanta VA Medical Center
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Savannah, Georgia, United States, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Savannah, Georgia, United States, 31405
- Summit Cancer Care-Candler
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Savannah, Georgia, United States, 31404
- Low Country Cancer Care
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Thomasville, Georgia, United States, 31792
- Lewis Hall Singletary Oncology Center
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Idaho
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Boise, Idaho, United States, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Boise, Idaho, United States, 83712
- Saint Luke's Cancer Institute - Boise
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Caldwell, Idaho, United States, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
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Coeur d'Alene, Idaho, United States, 83814
- Kootenai Health - Coeur d'Alene
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Emmett, Idaho, United States, 83617
- Walter Knox Memorial Hospital
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Fruitland, Idaho, United States, 83619
- Saint Luke's Cancer Institute - Fruitland
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Meridian, Idaho, United States, 83642
- Idaho Urologic Institute-Meridian
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Meridian, Idaho, United States, 83642
- Saint Luke's Cancer Institute - Meridian
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Nampa, Idaho, United States, 83686
- Saint Luke's Cancer Institute - Nampa
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Nampa, Idaho, United States, 83687
- Saint Alphonsus Cancer Care Center-Nampa
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Post Falls, Idaho, United States, 83854
- Kootenai Clinic Cancer Services - Post Falls
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Sandpoint, Idaho, United States, 83864
- Kootenai Cancer Clinic
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Twin Falls, Idaho, United States, 83301
- Saint Luke's Cancer Institute - Twin Falls
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Illinois
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Aurora, Illinois, United States, 60504
- Rush - Copley Medical Center
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Bloomington, Illinois, United States, 61704
- Illinois CancerCare-Bloomington
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Canton, Illinois, United States, 61520
- Illinois CancerCare-Canton
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Carbondale, Illinois, United States, 62902
- Memorial Hospital of Carbondale
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Carterville, Illinois, United States, 62918
- SIH Cancer Institute
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Carthage, Illinois, United States, 62321
- Illinois CancerCare-Carthage
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Centralia, Illinois, United States, 62801
- Centralia Oncology Clinic
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Chicago, Illinois, United States, 60637
- University of Chicago Comprehensive Cancer Center
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Chicago, Illinois, United States, 60612
- University of Illinois
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Chicago, Illinois, United States, 60612
- John H Stroger Jr Hospital of Cook County
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Danville, Illinois, United States, 61832
- Carle at The Riverfront
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Decatur, Illinois, United States, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, United States, 62526
- Cancer Care Specialists of Illinois - Decatur
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Effingham, Illinois, United States, 62401
- Crossroads Cancer Center
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Effingham, Illinois, United States, 62401
- Carle Physician Group-Effingham
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Eureka, Illinois, United States, 61530
- Illinois CancerCare-Eureka
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Evanston, Illinois, United States, 60201
- NorthShore University HealthSystem-Evanston Hospital
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Freeport, Illinois, United States, 61032
- Freeport Memorial Hospital/Leonard C Ferguson Cancer Center
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Galesburg, Illinois, United States, 61401
- Western Illinois Cancer Treatment Center
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Galesburg, Illinois, United States, 61401
- Illinois CancerCare-Galesburg
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Glenview, Illinois, United States, 60026
- NorthShore University HealthSystem-Glenbrook Hospital
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Highland Park, Illinois, United States, 60035
- NorthShore University HealthSystem-Highland Park Hospital
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Joliet, Illinois, United States, 60435
- Duly Health and Care Joliet
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Kankakee, Illinois, United States, 60901
- Presence Saint Mary's Hospital
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Kewanee, Illinois, United States, 61443
- Illinois CancerCare-Kewanee Clinic
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Macomb, Illinois, United States, 61455
- Illinois CancerCare-Macomb
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Mattoon, Illinois, United States, 61938
- Carle Physician Group-Mattoon/Charleston
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Maywood, Illinois, United States, 60153
- Loyola University Medical Center
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Melrose Park, Illinois, United States, 60160
- Marjorie Weinberg Cancer Center at Loyola-Gottlieb
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Mount Vernon, Illinois, United States, 62864
- Good Samaritan Regional Health Center
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New Lenox, Illinois, United States, 60451
- UC Comprehensive Cancer Center at Silver Cross
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O'Fallon, Illinois, United States, 62269
- Cancer Care Center of O'Fallon
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Orland Park, Illinois, United States, 60462
- University of Chicago Medicine-Orland Park
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Ottawa, Illinois, United States, 61350
- Illinois CancerCare-Ottawa Clinic
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Pekin, Illinois, United States, 61554
- Illinois CancerCare-Pekin
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Peoria, Illinois, United States, 61636
- Methodist Medical Center of Illinois
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Peoria, Illinois, United States, 61615
- Illinois CancerCare-Peoria
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Peru, Illinois, United States, 61354
- Illinois CancerCare-Peru
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Peru, Illinois, United States, 61354
- Valley Radiation Oncology
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Princeton, Illinois, United States, 61356
- Illinois CancerCare-Princeton
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Rockford, Illinois, United States, 61114
- SwedishAmerican Regional Cancer Center/ACT
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Skokie, Illinois, United States, 60076
- North Shore Medical Center
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Springfield, Illinois, United States, 62781
- Memorial Medical Center
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Springfield, Illinois, United States, 62702
- Southern Illinois University School of Medicine
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Springfield, Illinois, United States, 62702
- Springfield Clinic
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Swansea, Illinois, United States, 62226
- Southwest Illinois Health Services LLP
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Urbana, Illinois, United States, 61801
- Carle Cancer Center
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Urbana, Illinois, United States, 61801
- The Carle Foundation Hospital
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Yorkville, Illinois, United States, 60560
- Rush-Copley Healthcare Center
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Indiana
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Muncie, Indiana, United States, 47303
- IU Health Ball Memorial Hospital
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Richmond, Indiana, United States, 47374
- Reid Health
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Iowa
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Ames, Iowa, United States, 50010
- Mary Greeley Medical Center
-
Ames, Iowa, United States, 50010
- McFarland Clinic - Ames
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Boone, Iowa, United States, 50036
- McFarland Clinic - Boone
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Clive, Iowa, United States, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, United States, 50325
- Medical Oncology and Hematology Associates-West Des Moines
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Council Bluffs, Iowa, United States, 51503
- Alegent Health Mercy Hospital
-
Creston, Iowa, United States, 50801
- Greater Regional Medical Center
-
Des Moines, Iowa, United States, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, United States, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, United States, 50309
- Medical Oncology and Hematology Associates-Des Moines
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Des Moines, Iowa, United States, 50314
- Broadlawns Medical Center
-
Des Moines, Iowa, United States, 50314
- Mission Cancer and Blood - Laurel
-
Des Moines, Iowa, United States, 50316
- Iowa Lutheran Hospital
-
Fort Dodge, Iowa, United States, 50501
- Trinity Regional Medical Center
-
Fort Dodge, Iowa, United States, 50501
- McFarland Clinic - Trinity Cancer Center
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Jefferson, Iowa, United States, 50129
- McFarland Clinic - Jefferson
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Marshalltown, Iowa, United States, 50158
- McFarland Clinic - Marshalltown
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West Des Moines, Iowa, United States, 50266-7700
- Methodist West Hospital
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West Des Moines, Iowa, United States, 50266
- Mercy Medical Center-West Lakes
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Kansas
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Coffeyville, Kansas, United States, 67337
- Coffeyville Regional Medical Center
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Hays, Kansas, United States, 67601
- HaysMed University of Kansas Health System
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Kansas City, Kansas, United States, 66160
- University of Kansas Cancer Center
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Kansas City, Kansas, United States, 66112
- University of Kansas Cancer Center-West
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Lawrence, Kansas, United States, 66044
- Lawrence Memorial Hospital
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Olathe, Kansas, United States, 66061
- Olathe Health Cancer Center
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Overland Park, Kansas, United States, 66210
- University of Kansas Cancer Center-Overland Park
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Pittsburg, Kansas, United States, 66762
- Ascension Via Christi - Pittsburg
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Salina, Kansas, United States, 67401
- Salina Regional Health Center
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Topeka, Kansas, United States, 66606
- University of Kansas Health System Saint Francis Campus
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Westwood, Kansas, United States, 66205
- University of Kansas Hospital-Westwood Cancer Center
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Wichita, Kansas, United States, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
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Wichita, Kansas, United States, 67214
- Cancer Center of Kansas - Wichita
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Kentucky
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Bardstown, Kentucky, United States, 40004
- Flaget Memorial Hospital
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Corbin, Kentucky, United States, 40701
- Baptist Health Corbin
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Corbin, Kentucky, United States, 40701
- Commonwealth Cancer Center-Corbin
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Edgewood, Kentucky, United States, 41017
- Saint Elizabeth Healthcare Edgewood
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Fort Thomas, Kentucky, United States, 41075
- Saint Elizabeth Fort Thomas
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Lexington, Kentucky, United States, 40504
- Saint Joseph Radiation Oncology Resource Center
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Lexington, Kentucky, United States, 40509
- Saint Joseph Hospital East
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Lexington, Kentucky, United States, 40503
- Baptist Health Lexington
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London, Kentucky, United States, 40741
- Saint Joseph London
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Louisville, Kentucky, United States, 40202
- Jewish Hospital
-
Louisville, Kentucky, United States, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, United States, 40207
- Baptist Health Louisville
-
Louisville, Kentucky, United States, 40215
- Saints Mary and Elizabeth Hospital
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Madisonville, Kentucky, United States, 42431
- Baptist Health Madisonville/Merle Mahr Cancer Center
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Paducah, Kentucky, United States, 42003
- Baptist Health Paducah
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Shepherdsville, Kentucky, United States, 40165
- Jewish Hospital Medical Center South
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Louisiana
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Baton Rouge, Louisiana, United States, 70805
- LSU Health Baton Rouge-North Clinic
-
Baton Rouge, Louisiana, United States, 70809
- Louisiana Hematology Oncology Associates LLC
-
Baton Rouge, Louisiana, United States, 70809
- Mary Bird Perkins Cancer Center
-
Baton Rouge, Louisiana, United States, 70809
- Our Lady of the Lake Physicians Group - Medical Oncology
-
Baton Rouge, Louisiana, United States, 70809
- Ochsner Health Center-Summa
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Baton Rouge, Louisiana, United States, 70816
- Medical Center of Baton Rouge
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Covington, Louisiana, United States, 70433
- Northshore Oncology Associates-Covington
-
Houma, Louisiana, United States, 70360
- Oncology Center of The South Incorporated
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New Orleans, Louisiana, United States, 70121
- Ochsner Medical Center Jefferson
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Maine
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Augusta, Maine, United States, 04330
- Harold Alfond Center for Cancer Care
-
Bangor, Maine, United States, 04401
- Eastern Maine Medical Center
-
Belfast, Maine, United States, 04915
- Waldo County General Hospital
-
Biddeford, Maine, United States, 04005
- MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford
-
Brewer, Maine, United States, 04412
- Lafayette Family Cancer Center-EMMC
-
Rockport, Maine, United States, 04856
- Penobscot Bay Medical Center
-
Sanford, Maine, United States, 04073
- MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford
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Maryland
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Baltimore, Maryland, United States, 21204
- Greater Baltimore Medical Center
-
Baltimore, Maryland, United States, 21229
- Saint Agnes Hospital
-
Cumberland, Maryland, United States, 21502
- UPMC Western Maryland
-
Easton, Maryland, United States, 21601
- University of Maryland Shore Medical Center at Easton
-
Frederick, Maryland, United States, 21701
- Frederick Memorial Hospital
-
Salisbury, Maryland, United States, 21801
- TidalHealth Peninsula Regional
-
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Massachusetts
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Beverly, Massachusetts, United States, 01915
- Beverly Hospital
-
Boston, Massachusetts, United States, 02118
- Boston Medical Center
-
Burlington, Massachusetts, United States, 01805
- Lahey Hospital and Medical Center
-
Fitchburg, Massachusetts, United States, 01420
- Simonds-Sinon Regional Cancer Center
-
Gloucester, Massachusetts, United States, 01930
- Addison Gilbert Hospital
-
Lowell, Massachusetts, United States, 01854
- Lowell General Hospital
-
Springfield, Massachusetts, United States, 01199
- Baystate Medical Center
-
Springfield, Massachusetts, United States, 01104
- Mercy Medical Center
-
Winchester, Massachusetts, United States, 01890
- Winchester Hospital
-
Worcester, Massachusetts, United States, 01655
- UMass Memorial Medical Center - University Campus
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Michigan
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Adrian, Michigan, United States, 49221
- Hickman Cancer Center
-
Ann Arbor, Michigan, United States, 48106
- Saint Joseph Mercy Hospital
-
Battle Creek, Michigan, United States, 49017
- Bronson Battle Creek
-
Bay City, Michigan, United States, 48706
- McLaren Cancer Institute-Bay City
-
Bloomfield, Michigan, United States, 48302
- McLaren Cancer Institute-Bloomfield
-
Brighton, Michigan, United States, 48114
- Saint Joseph Mercy Brighton
-
Brighton, Michigan, United States, 48114
- Trinity Health IHA Medical Group Hematology Oncology - Brighton
-
Canton, Michigan, United States, 48188
- Saint Joseph Mercy Canton
-
Canton, Michigan, United States, 48188
- Trinity Health IHA Medical Group Hematology Oncology - Canton
-
Caro, Michigan, United States, 48723
- Caro Cancer Center
-
Chelsea, Michigan, United States, 48118
- Saint Joseph Mercy Chelsea
-
Chelsea, Michigan, United States, 48118
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
-
Clarkston, Michigan, United States, 48346
- McLaren Cancer Institute-Clarkston
-
Clarkston, Michigan, United States, 48346
- Hematology Oncology Consultants-Clarkston
-
Clarkston, Michigan, United States, 48346
- Newland Medical Associates-Clarkston
-
Detroit, Michigan, United States, 48201
- Wayne State University/Karmanos Cancer Institute
-
Detroit, Michigan, United States, 48236
- Ascension Saint John Hospital
-
East China Township, Michigan, United States, 48054
- Great Lakes Cancer Management Specialists-Doctors Park
-
East Lansing, Michigan, United States, 48824
- Michigan State University Clinical Center
-
Escanaba, Michigan, United States, 49829
- Green Bay Oncology - Escanaba
-
Farmington Hills, Michigan, United States, 48334
- Weisberg Cancer Treatment Center
-
Flint, Michigan, United States, 48532
- McLaren Cancer Institute-Flint
-
Flint, Michigan, United States, 48532
- Singh and Arora Hematology Oncology PC
-
Flint, Michigan, United States, 48503
- Hurley Medical Center
-
Flint, Michigan, United States, 48503
- Genesee Cancer and Blood Disease Treatment Center
-
Flint, Michigan, United States, 48503
- Genesee Hematology Oncology PC
-
Flint, Michigan, United States, 48503
- Genesys Hurley Cancer Institute
-
Grand Rapids, Michigan, United States, 49503
- Spectrum Health at Butterworth Campus
-
Grand Rapids, Michigan, United States, 49503
- Trinity Health Grand Rapids Hospital
-
Grosse Pointe Woods, Michigan, United States, 48236
- Academic Hematology Oncology Specialists
-
Grosse Pointe Woods, Michigan, United States, 48236
- Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
-
Grosse Pointe Woods, Michigan, United States, 48236
- Michigan Breast Specialists-Grosse Pointe Woods
-
Kalamazoo, Michigan, United States, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, United States, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, United States, 49048
- Borgess Medical Center
-
Lansing, Michigan, United States, 48910
- Karmanos Cancer Institute at McLaren Greater Lansing
-
Lansing, Michigan, United States, 48912
- University of Michigan Health - Sparrow Lansing
-
Lapeer, Michigan, United States, 48446
- McLaren Cancer Institute-Lapeer Region
-
Livonia, Michigan, United States, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Livonia, Michigan, United States, 48154
- Hope Cancer Clinic
-
Macomb, Michigan, United States, 48044
- Great Lakes Cancer Management Specialists-Macomb Medical Campus
-
Macomb, Michigan, United States, 48044
- Michigan Breast Specialists-Macomb Township
-
Marlette, Michigan, United States, 48453
- Saint Mary's Oncology/Hematology Associates of Marlette
-
Monroe, Michigan, United States, 48162
- Toledo Clinic Cancer Centers-Monroe
-
Mount Clemens, Michigan, United States, 48043
- McLaren Cancer Institute-Macomb
-
Muskegon, Michigan, United States, 49444
- Trinity Health Muskegon Hospital
-
Niles, Michigan, United States, 49120
- Corewell Health Lakeland Hospitals - Niles Hospital
-
Novi, Michigan, United States, 48374
- Ascension Providence Hospitals - Novi
-
Petoskey, Michigan, United States, 49770
- McLaren Cancer Institute-Northern Michigan
-
Pontiac, Michigan, United States, 48341
- Saint Joseph Mercy Oakland
-
Pontiac, Michigan, United States, 48341
- 21st Century Oncology-Pontiac
-
Pontiac, Michigan, United States, 48341
- Hope Cancer Center
-
Pontiac, Michigan, United States, 48341
- Newland Medical Associates-Pontiac
-
Port Huron, Michigan, United States, 48060
- McLaren-Port Huron
-
Port Huron, Michigan, United States, 48060
- Lake Huron Medical Center
-
Port Huron, Michigan, United States, 48060
- Huron Medical Center PC
-
Reed City, Michigan, United States, 49677
- Corewell Health Reed City Hospital
-
Rochester Hills, Michigan, United States, 48309
- Great Lakes Cancer Management Specialists-Rochester Hills
-
Saginaw, Michigan, United States, 48601
- Ascension Saint Mary's Hospital
-
Saginaw, Michigan, United States, 48604
- Oncology Hematology Associates of Saginaw Valley PC
-
Saint Joseph, Michigan, United States, 49085
- Lakeland Medical Center Saint Joseph
-
Saint Joseph, Michigan, United States, 49085
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
-
Southfield, Michigan, United States, 48075
- Ascension Providence Hospitals - Southfield
-
Sterling Heights, Michigan, United States, 48312
- Bhadresh Nayak MD PC-Sterling Heights
-
Tawas City, Michigan, United States, 48764
- Ascension Saint Joseph Hospital
-
Traverse City, Michigan, United States, 49684
- Munson Medical Center
-
Warren, Michigan, United States, 48093
- Saint John Macomb-Oakland Hospital
-
Warren, Michigan, United States, 48088
- Advanced Breast Care Center PLLC
-
Warren, Michigan, United States, 48093
- Great Lakes Cancer Management Specialists-Macomb Professional Building
-
Warren, Michigan, United States, 48093
- Macomb Hematology Oncology PC
-
Warren, Michigan, United States, 48093
- Michigan Breast Specialists-Warren
-
West Branch, Michigan, United States, 48661
- Saint Mary's Oncology/Hematology Associates of West Branch
-
Wyoming, Michigan, United States, 49519
- University of Michigan Health - West
-
Ypsilanti, Michigan, United States, 48197
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
-
Ypsilanti, Michigan, United States, 48106
- Huron Gastroenterology PC
-
-
Minnesota
-
Bemidji, Minnesota, United States, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, United States, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, United States, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, United States, 55433
- Mercy Hospital
-
Deer River, Minnesota, United States, 56636
- Essentia Health - Deer River Clinic
-
Detroit Lakes, Minnesota, United States, 56501
- Essentia Health Saint Mary's - Detroit Lakes Clinic
-
Duluth, Minnesota, United States, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, United States, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, United States, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, United States, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, United States, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fosston, Minnesota, United States, 56542
- Essentia Health - Fosston
-
Fridley, Minnesota, United States, 55432
- Unity Hospital
-
Hibbing, Minnesota, United States, 55746
- Essentia Health Hibbing Clinic
-
Maple Grove, Minnesota, United States, 55369
- Fairview Clinics and Surgery Center Maple Grove
-
Maplewood, Minnesota, United States, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, United States, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, United States, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, United States, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, United States, 55454
- Health Partners Inc
-
Monticello, Minnesota, United States, 55362
- Monticello Cancer Center
-
New Ulm, Minnesota, United States, 56073
- New Ulm Medical Center
-
Park Rapids, Minnesota, United States, 56470
- Essentia Health - Park Rapids
-
Robbinsdale, Minnesota, United States, 55422
- North Memorial Medical Health Center
-
Saint Louis Park, Minnesota, United States, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, United States, 55101
- Regions Hospital
-
Saint Paul, Minnesota, United States, 55102
- United Hospital
-
Sandstone, Minnesota, United States, 55072
- Essentia Health Sandstone
-
Shakopee, Minnesota, United States, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, United States, 55082
- Lakeview Hospital
-
Thief River Falls, Minnesota, United States, 56701
- Sanford Thief River Falls Medical Center
-
Virginia, Minnesota, United States, 55792
- Essentia Health Virginia Clinic
-
Waconia, Minnesota, United States, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, United States, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, United States, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
Worthington, Minnesota, United States, 56187
- Sanford Cancer Center Worthington
-
Wyoming, Minnesota, United States, 55092
- Fairview Lakes Medical Center
-
-
Mississippi
-
Hattiesburg, Mississippi, United States, 39401
- Hattiesburg Clinic - Hematology/Oncology Clinic
-
Hattiesburg, Mississippi, United States, 39404
- Forrest General Hospital / Cancer Center
-
Pascagoula, Mississippi, United States, 39581
- Singing River Hospital
-
-
Missouri
-
Ballwin, Missouri, United States, 63011
- Saint Louis Cancer and Breast Institute-Ballwin
-
Bonne Terre, Missouri, United States, 63628
- Parkland Health Center-Bonne Terre
-
Branson, Missouri, United States, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, United States, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, United States, 63703
- Southeast Cancer Center
-
Jefferson City, Missouri, United States, 65109
- Capital Region Southwest Campus
-
Joplin, Missouri, United States, 64804
- Freeman Health System
-
Joplin, Missouri, United States, 64804
- Mercy Hospital Joplin
-
Kansas City, Missouri, United States, 64154
- University of Kansas Cancer Center - North
-
Kansas City, Missouri, United States, 64131
- The University of Kansas Cancer Center-South
-
Kansas City, Missouri, United States, 64108
- Truman Medical Centers
-
Lee's Summit, Missouri, United States, 64064
- University of Kansas Cancer Center - Lee's Summit
-
Rolla, Missouri, United States, 65401
- Delbert Day Cancer Institute at PCRMC
-
Rolla, Missouri, United States, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Saint Joseph, Missouri, United States, 64506
- Heartland Regional Medical Center
-
Saint Louis, Missouri, United States, 63141
- Mercy Hospital Saint Louis
-
Saint Louis, Missouri, United States, 63128
- Mercy Hospital South
-
Saint Louis, Missouri, United States, 63109
- Saint Louis Cancer and Breast Institute-South City
-
Sainte Genevieve, Missouri, United States, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, United States, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, United States, 65804
- Mercy Hospital Springfield
-
Sullivan, Missouri, United States, 63080
- Missouri Baptist Sullivan Hospital
-
Sunset Hills, Missouri, United States, 63127
- BJC Outpatient Center at Sunset Hills
-
Washington, Missouri, United States, 63090
- Mercy Hospital Washington
-
-
Montana
-
Anaconda, Montana, United States, 59711
- Community Hospital of Anaconda
-
Billings, Montana, United States, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, United States, 59101
- Saint Vincent Healthcare
-
Billings, Montana, United States, 59102
- Saint Vincent Frontier Cancer Center
-
Bozeman, Montana, United States, 59715
- Bozeman Deaconess Hospital
-
Butte, Montana, United States, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, United States, 59405
- Great Falls Clinic
-
Great Falls, Montana, United States, 59405
- Benefis Healthcare- Sletten Cancer Institute
-
Helena, Montana, United States, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, United States, 59901
- Kalispell Regional Medical Center
-
Missoula, Montana, United States, 59804
- Community Medical Hospital
-
Missoula, Montana, United States, 59802
- Saint Patrick Hospital - Community Hospital
-
-
Nebraska
-
Grand Island, Nebraska, United States, 68803
- CHI Health Saint Francis
-
Kearney, Nebraska, United States, 68847
- CHI Health Good Samaritan
-
Kearney, Nebraska, United States, 68845
- Heartland Hematology and Oncology
-
Lincoln, Nebraska, United States, 68506
- Nebraska Hematology and Oncology
-
Lincoln, Nebraska, United States, 68510
- Nebraska Cancer Research Center
-
Lincoln, Nebraska, United States, 68516
- Southeast Nebraska Cancer Center - 68th Street Place
-
Lincoln, Nebraska, United States, 68510
- Saint Elizabeth Regional Medical Center
-
Norfolk, Nebraska, United States, 68701
- Faith Regional Health Services Carson Cancer Center
-
North Platte, Nebraska, United States, 69101
- Great Plains Health Callahan Cancer Center
-
Omaha, Nebraska, United States, 68114
- Nebraska Methodist Hospital
-
Omaha, Nebraska, United States, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, United States, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, United States, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, United States, 68131
- Creighton University Medical Center
-
Omaha, Nebraska, United States, 68124
- Nebraska Cancer Specialists - Omaha
-
Omaha, Nebraska, United States, 68130
- Oncology Hematology West PC
-
Omaha, Nebraska, United States, 68122
- Hematology and Oncology Consultants PC
-
Papillion, Nebraska, United States, 68046
- Midlands Community Hospital
-
Scottsbluff, Nebraska, United States, 69361
- Regional West Medical Center Cancer Center
-
-
Nevada
-
Carson City, Nevada, United States, 89703
- Carson Tahoe Regional Medical Center
-
Henderson, Nevada, United States, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, United States, 89052
- OptumCare Cancer Care at Seven Hills
-
Henderson, Nevada, United States, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, United States, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, United States, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, United States, 89074
- GenesisCare USA - Henderson
-
Henderson, Nevada, United States, 89052
- Comprehensive Cancer Centers of Nevada-Horizon Ridge
-
Las Vegas, Nevada, United States, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, United States, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, United States, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, United States, 89109
- GenesisCare USA - Las Vegas
-
Las Vegas, Nevada, United States, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, United States, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, United States, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, United States, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, United States, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, United States, 89148
- OptumCare Cancer Care at Fort Apache
-
Las Vegas, Nevada, United States, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, United States, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, United States, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, United States, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, United States, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, United States, 89121
- Cancer Therapy and Integrative Medicine
-
Las Vegas, Nevada, United States, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, United States, 89128
- GenesisCare USA - Vegas Tenaya
-
Las Vegas, Nevada, United States, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, United States, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, United States, 89148
- GenesisCare USA - Fort Apache
-
Las Vegas, Nevada, United States, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, United States, 89128
- Ann M Wierman MD LTD
-
Las Vegas, Nevada, United States, 89102
- Desert West Surgery
-
Las Vegas, Nevada, United States, 89103
- Hope Cancer Care of Nevada
-
Las Vegas, Nevada, United States, 89169
- University Cancer Center
-
Pahrump, Nevada, United States, 89048
- Hope Cancer Care of Nevada-Pahrump
-
Reno, Nevada, United States, 89502
- Renown Regional Medical Center
-
Reno, Nevada, United States, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, United States, 89509
- Radiation Oncology Associates
-
-
New Hampshire
-
Concord, New Hampshire, United States, 03301
- New Hampshire Oncology Hematology PA-Concord
-
Manchester, New Hampshire, United States, 03103
- Solinsky Center for Cancer Care
-
-
New Jersey
-
Brick, New Jersey, United States, 08724
- Ocean University Medical Center
-
Holmdel, New Jersey, United States, 07733
- Bayshore Community Hospital
-
Jackson, New Jersey, United States, 08527
- Meridian Health Village at Jackson
-
Manahawkin, New Jersey, United States, 08050
- Southern Ocean County Medical Center
-
Morristown, New Jersey, United States, 07960
- Morristown Medical Center
-
Mount Holly, New Jersey, United States, 08060
- Virtua Memorial
-
Mullica Hill, New Jersey, United States, 08062
- Inspira Medical Center Mullica Hill
-
Neptune, New Jersey, United States, 07753
- Jersey Shore Medical Center
-
Paramus, New Jersey, United States, 07652
- The Valley Hospital-Luckow Pavilion
-
Red Bank, New Jersey, United States, 07701
- Riverview Medical Center/Booker Cancer Center
-
Ridgewood, New Jersey, United States, 07450
- Valley Hospital
-
Ridgewood, New Jersey, United States, 07450
- Neurosurgeons of New Jersey-Ridgewood
-
Summit, New Jersey, United States, 07902
- Overlook Hospital
-
Vineland, New Jersey, United States, 08360
- Inspira Medical Center Vineland
-
Voorhees, New Jersey, United States, 08043
- Virtua Voorhees
-
Wayne, New Jersey, United States, 07470
- Valley Medical Group - Wayne Multispecialty Practice
-
Westwood, New Jersey, United States, 07675
- Valley Health System-Hematology/Oncology
-
-
New York
-
Bronx, New York, United States, 10461
- Montefiore Medical Center-Einstein Campus
-
Bronx, New York, United States, 10467
- Montefiore Medical Center - Moses Campus
-
Bronx, New York, United States, 10461
- Montefiore Medical Center-Weiler Hospital
-
Cooperstown, New York, United States, 13326
- Mary Imogene Bassett Hospital
-
Elmira, New York, United States, 14905
- Arnot Ogden Medical Center/Falck Cancer Center
-
Middletown, New York, United States, 10940
- Garnet Health Medical Center
-
New York, New York, United States, 10065
- NYP/Weill Cornell Medical Center
-
Rochester, New York, United States, 14642
- University of Rochester
-
Syracuse, New York, United States, 13210
- State University of New York Upstate Medical University
-
Syracuse, New York, United States, 13215
- SUNY Upstate Medical Center-Community Campus
-
White Plains, New York, United States, 10601
- Dickstein Cancer Treatment Center
-
-
North Carolina
-
Asheboro, North Carolina, United States, 27203
- Randolph Hospital
-
Asheville, North Carolina, United States, 28801
- Mission Hospital
-
Burlington, North Carolina, United States, 27215
- Cone Health Cancer Center at Alamance Regional
-
Clinton, North Carolina, United States, 28328
- Southeastern Medical Oncology Center-Clinton
-
Goldsboro, North Carolina, United States, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, United States, 27534
- Wayne Memorial Hospital
-
Greensboro, North Carolina, United States, 27403
- Cone Health Cancer Center
-
Hendersonville, North Carolina, United States, 28791
- Margaret R Pardee Memorial Hospital
-
Jacksonville, North Carolina, United States, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Jacksonville, North Carolina, United States, 28546
- Onslow Memorial Hospital
-
Mebane, North Carolina, United States, 27302
- Cone Heath Cancer Center at Mebane
-
Pinehurst, North Carolina, United States, 28374
- FirstHealth of the Carolinas-Moore Regional Hospital
-
Reidsville, North Carolina, United States, 27320
- Annie Penn Memorial Hospital
-
-
North Dakota
-
Bismarck, North Dakota, United States, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, United States, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, United States, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, United States, 58122
- Sanford Broadway Medical Center
-
Fargo, North Dakota, United States, 58103
- Sanford South University Medical Center
-
Jamestown, North Dakota, United States, 58401
- Essentia Health - Jamestown Clinic
-
Minot, North Dakota, United States, 58701
- Trinity Cancer Care Center
-
-
Ohio
-
Akron, Ohio, United States, 44307
- Cleveland Clinic Akron General
-
Akron, Ohio, United States, 44304
- Summa Health System - Akron Campus
-
Beachwood, Ohio, United States, 44122
- UHHS-Chagrin Highlands Medical Center
-
Beavercreek, Ohio, United States, 45431
- Indu and Raj Soin Medical Center
-
Belpre, Ohio, United States, 45714
- Strecker Cancer Center-Belpre
-
Canton, Ohio, United States, 44708
- Cleveland Clinic Mercy Hospital
-
Canton, Ohio, United States, 44710
- Aultman Health Foundation
-
Centerville, Ohio, United States, 45459
- Miami Valley Hospital South
-
Centerville, Ohio, United States, 45459
- Dayton Physicians LLC-Miami Valley South
-
Chardon, Ohio, United States, 44024
- Geauga Hospital
-
Chillicothe, Ohio, United States, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, United States, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, United States, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, United States, 45236
- Oncology Hematology Care Inc-Kenwood
-
Cincinnati, Ohio, United States, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, United States, 45255
- TriHealth Cancer Institute-Anderson
-
Cleveland, Ohio, United States, 44106
- Case Western Reserve University
-
Cleveland, Ohio, United States, 44109
- MetroHealth Medical Center
-
Cleveland, Ohio, United States, 44195
- Cleveland Clinic Foundation
-
Cleveland, Ohio, United States, 44111
- Cleveland Clinic Cancer Center/Fairview Hospital
-
Columbus, Ohio, United States, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, United States, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, United States, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, United States, 43228
- Doctors Hospital
-
Columbus, Ohio, United States, 43213
- Mount Carmel East Hospital
-
Columbus, Ohio, United States, 43215
- Grant Medical Center
-
Columbus, Ohio, United States, 43222
- Mount Carmel Health Center West
-
Dayton, Ohio, United States, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, United States, 45409
- Miami Valley Hospital
-
Dayton, Ohio, United States, 45415
- Dayton Physician LLC-Miami Valley Hospital North
-
Dayton, Ohio, United States, 45415
- Miami Valley Hospital North
-
Delaware, Ohio, United States, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, United States, 43015
- Delaware Radiation Oncology
-
Delaware, Ohio, United States, 43015
- Grady Memorial Hospital
-
Elyria, Ohio, United States, 44035
- Mercy Cancer Center-Elyria
-
Findlay, Ohio, United States, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, United States, 45840
- Armes Family Cancer Center
-
Findlay, Ohio, United States, 45840
- Orion Cancer Care
-
Franklin, Ohio, United States, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Franklin, Ohio, United States, 45005
- Dayton Physicians LLC-Atrium
-
Greenville, Ohio, United States, 45331
- Wayne Hospital
-
Greenville, Ohio, United States, 45331
- Dayton Physicians LLC-Wayne
-
Kettering, Ohio, United States, 45429
- Kettering Medical Center
-
Kettering, Ohio, United States, 45409
- Greater Dayton Cancer Center
-
Kettering, Ohio, United States, 45420
- First Dayton Cancer Care
-
Lancaster, Ohio, United States, 43130
- Fairfield Medical Center
-
Mansfield, Ohio, United States, 44906
- Cleveland Clinic Cancer Center Mansfield
-
Mansfield, Ohio, United States, 44903
- OhioHealth Mansfield Hospital
-
Marietta, Ohio, United States, 45750
- Marietta Memorial Hospital
-
Marion, Ohio, United States, 43302
- OhioHealth Marion General Hospital
-
Maumee, Ohio, United States, 43537
- Toledo Clinic Cancer Centers-Maumee
-
Maumee, Ohio, United States, 43537
- Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
-
Mayfield Heights, Ohio, United States, 44124
- Hillcrest Hospital Cancer Center
-
Mentor, Ohio, United States, 44060
- UH Seidman Cancer Center at Lake Health Mentor Campus
-
Middleburg Heights, Ohio, United States, 44130
- UH Seidman Cancer Center at Southwest General Hospital
-
Mount Vernon, Ohio, United States, 43050
- Knox Community Hospital
-
Newark, Ohio, United States, 43055
- Licking Memorial Hospital
-
Newark, Ohio, United States, 43055
- Newark Radiation Oncology
-
Parma, Ohio, United States, 44129
- University Hospitals Parma Medical Center
-
Perrysburg, Ohio, United States, 43551
- Mercy Health Perrysburg Cancer Center
-
Portsmouth, Ohio, United States, 45662
- Southern Ohio Medical Center
-
Sandusky, Ohio, United States, 44870
- North Coast Cancer Care
-
Springfield, Ohio, United States, 45505
- Springfield Regional Medical Center
-
Springfield, Ohio, United States, 45504
- Springfield Regional Cancer Center
-
Toledo, Ohio, United States, 43623
- Mercy Health - Saint Anne Hospital
-
Toledo, Ohio, United States, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Troy, Ohio, United States, 45373
- Upper Valley Medical Center
-
Troy, Ohio, United States, 45373
- Dayton Physicians LLC - Troy
-
Warrensville Heights, Ohio, United States, 44122
- South Pointe Hospital
-
Westerville, Ohio, United States, 43081
- Saint Ann's Hospital
-
Westlake, Ohio, United States, 44145
- UH Seidman Cancer Center at Saint John Medical Center
-
Westlake, Ohio, United States, 44145
- UHHS-Westlake Medical Center
-
Wooster, Ohio, United States, 44691
- Cleveland Clinic Wooster Family Health and Surgery Center
-
Zanesville, Ohio, United States, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, United States, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, United States, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, United States, 73120
- Mercy Hospital Oklahoma City
-
Tulsa, Oklahoma, United States, 74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
-
Oregon
-
Baker City, Oregon, United States, 97814
- Saint Alphonsus Medical Center-Baker City
-
Bend, Oregon, United States, 97701
- Saint Charles Health System
-
Clackamas, Oregon, United States, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, United States, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, United States, 97420
- Bay Area Hospital
-
Gresham, Oregon, United States, 97030
- Legacy Mount Hood Medical Center
-
Newberg, Oregon, United States, 97132
- Providence Newberg Medical Center
-
Ontario, Oregon, United States, 97914
- Saint Alphonsus Medical Center-Ontario
-
Portland, Oregon, United States, 97210
- Legacy Good Samaritan Hospital and Medical Center
-
Portland, Oregon, United States, 97213
- Providence Portland Medical Center
-
Portland, Oregon, United States, 97225
- Providence Saint Vincent Medical Center
-
Redmond, Oregon, United States, 97756
- Saint Charles Health System-Redmond
-
Tualatin, Oregon, United States, 97062
- Legacy Meridian Park Hospital
-
-
Pennsylvania
-
Allentown, Pennsylvania, United States, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, United States, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Bethlehem, Pennsylvania, United States, 18015
- Saint Luke's University Hospital-Bethlehem Campus
-
Bryn Mawr, Pennsylvania, United States, 19010
- Bryn Mawr Hospital
-
Chadds Ford, Pennsylvania, United States, 19317
- Christiana Care Health System-Concord Health Center
-
Danville, Pennsylvania, United States, 17822
- Geisinger Medical Center
-
East Stroudsburg, Pennsylvania, United States, 18301
- Pocono Medical Center
-
Ephrata, Pennsylvania, United States, 17522
- Ephrata Cancer Center
-
Ephrata, Pennsylvania, United States, 17522
- Ephrata Community Hospital
-
Gettysburg, Pennsylvania, United States, 17325
- Adams Cancer Center
-
Hanover, Pennsylvania, United States, 17331
- Cherry Tree Cancer Center
-
Hazleton, Pennsylvania, United States, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hazleton, Pennsylvania, United States, 18201
- Lehigh Valley Hospital-Hazleton
-
Lebanon, Pennsylvania, United States, 17042
- Sechler Family Cancer Center
-
Lewisburg, Pennsylvania, United States, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, United States, 17044
- Lewistown Hospital
-
Media, Pennsylvania, United States, 19063
- Riddle Memorial Hospital
-
Paoli, Pennsylvania, United States, 19301
- Paoli Memorial Hospital
-
Pottstown, Pennsylvania, United States, 19464
- Pottstown Hospital
-
Pottsville, Pennsylvania, United States, 17901
- Geisinger Cancer Services-Pottsville
-
Reading, Pennsylvania, United States, 19605
- Penn State Health Saint Joseph Medical Center
-
Sayre, Pennsylvania, United States, 18840
- Guthrie Medical Group PC-Robert Packer Hospital
-
Scranton, Pennsylvania, United States, 18510
- Community Medical Center
-
Selinsgrove, Pennsylvania, United States, 17870
- Geisinger Medical Oncology-Selinsgrove
-
State College, Pennsylvania, United States, 16801
- Geisinger Medical Group
-
West Chester, Pennsylvania, United States, 19380
- Chester County Hospital
-
West Reading, Pennsylvania, United States, 19611
- Reading Hospital
-
Wilkes-Barre, Pennsylvania, United States, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Wynnewood, Pennsylvania, United States, 19096
- Lankenau Medical Center
-
York, Pennsylvania, United States, 17403
- WellSpan Health-York Cancer Center
-
York, Pennsylvania, United States, 17403
- WellSpan Health-York Hospital
-
-
South Carolina
-
Boiling Springs, South Carolina, United States, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Charleston, South Carolina, United States, 29425
- Medical University of South Carolina
-
Clinton, South Carolina, United States, 29325
- Prisma Health Cancer Institute - Laurens
-
Easley, South Carolina, United States, 29640
- Prisma Health Cancer Institute - Easley
-
Gaffney, South Carolina, United States, 29341
- Gibbs Cancer Center-Gaffney
-
Greenville, South Carolina, United States, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, United States, 29607
- Saint Francis Cancer Center
-
Greenville, South Carolina, United States, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, United States, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, United States, 29601
- Saint Francis Hospital
-
Greenville, South Carolina, United States, 29605
- Prisma Health Greenville Memorial Hospital
-
Greenwood, South Carolina, United States, 29646
- Self Regional Healthcare
-
Greer, South Carolina, United States, 29650
- Prisma Health Cancer Institute - Greer
-
Greer, South Carolina, United States, 29651
- Gibbs Cancer Center-Pelham
-
Seneca, South Carolina, United States, 29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg, South Carolina, United States, 29303
- Spartanburg Medical Center
-
Union, South Carolina, United States, 29379
- MGC Hematology Oncology-Union
-
-
South Dakota
-
Aberdeen, South Dakota, United States, 57401
- Avera Cancer Institute-Aberdeen
-
Sioux Falls, South Dakota, United States, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, United States, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, United States, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Bristol, Tennessee, United States, 37620
- Bristol Regional Medical Center
-
Chattanooga, Tennessee, United States, 37404
- Memorial Hospital
-
Hixson, Tennessee, United States, 37343
- Pulmonary Medicine Center of Chattanooga-Hixson
-
Johnson City, Tennessee, United States, 37604
- Wellmont Medical Associates Oncology and Hematology-Johnson City
-
Kingsport, Tennessee, United States, 37660
- Ballad Health Cancer Care - Kingsport
-
Kingsport, Tennessee, United States, 37660
- Wellmont Holston Valley Hospital and Medical Center
-
Ooltewah, Tennessee, United States, 37363
- Memorial GYN Plus
-
-
Texas
-
Bryan, Texas, United States, 77802
- Saint Joseph Regional Cancer Center
-
Dallas, Texas, United States, 75235
- Parkland Memorial Hospital
-
Dallas, Texas, United States, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
Fort Worth, Texas, United States, 76104
- UT Southwestern/Simmons Cancer Center-Fort Worth
-
-
Virginia
-
Bristol, Virginia, United States, 24201
- Wellmont Medical Associates-Bristol
-
Charlottesville, Virginia, United States, 22908
- University of Virginia Cancer Center
-
Fishersville, Virginia, United States, 22939
- Augusta Health Center for Cancer and Blood Disorders
-
Martinsville, Virginia, United States, 24115
- Sovah Health Martinsville
-
Mechanicsville, Virginia, United States, 23116
- Bon Secours Memorial Regional Medical Center
-
Midlothian, Virginia, United States, 23114
- Bon Secours Saint Francis Medical Center
-
Norfolk, Virginia, United States, 23505
- Bon Secours DePaul Medical Center
-
Norton, Virginia, United States, 24273
- Southwest VA Regional Cancer Center
-
Richmond, Virginia, United States, 23226
- Bon Secours Saint Mary's Hospital
-
Suffolk, Virginia, United States, 23435
- Bon Secours Health Center at Harbour View
-
-
Washington
-
Aberdeen, Washington, United States, 98520
- Providence Regional Cancer System-Aberdeen
-
Bellingham, Washington, United States, 98225
- PeaceHealth Saint Joseph Medical Center
-
Bremerton, Washington, United States, 98310
- Harrison HealthPartners Hematology and Oncology-Bremerton
-
Bremerton, Washington, United States, 98310
- Harrison Medical Center
-
Burien, Washington, United States, 98166
- Highline Medical Center-Main Campus
-
Centralia, Washington, United States, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, United States, 98026
- Swedish Cancer Institute-Edmonds
-
Enumclaw, Washington, United States, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, United States, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, United States, 98003
- Saint Francis Hospital
-
Issaquah, Washington, United States, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, United States, 99336
- Kadlec Clinic Hematology and Oncology
-
Lacey, Washington, United States, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, United States, 98499
- Saint Clare Hospital
-
Longview, Washington, United States, 98632
- PeaceHealth Saint John Medical Center
-
Poulsbo, Washington, United States, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Seattle, Washington, United States, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, United States, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, United States, 98112
- Kaiser Permanente Washington
-
Seattle, Washington, United States, 98104
- Pacific Gynecology Specialists
-
Seattle, Washington, United States, 98122-5711
- Swedish Medical Center-Cherry Hill
-
Sedro-Woolley, Washington, United States, 98284
- PeaceHealth United General Medical Center
-
Shelton, Washington, United States, 98584
- Providence Regional Cancer System-Shelton
-
Tacoma, Washington, United States, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, United States, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Vancouver, Washington, United States, 98686
- Legacy Salmon Creek Hospital
-
Vancouver, Washington, United States, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, United States, 99362
- Providence Saint Mary Regional Cancer Center
-
Yelm, Washington, United States, 98597
- Providence Regional Cancer System-Yelm
-
-
West Virginia
-
Charleston, West Virginia, United States, 25304
- West Virginia University Charleston Division
-
Huntington, West Virginia, United States, 25701
- Edwards Comprehensive Cancer Center
-
-
Wisconsin
-
Antigo, Wisconsin, United States, 54409
- Langlade Hospital and Cancer Center
-
Ashland, Wisconsin, United States, 54806
- Duluth Clinic Ashland
-
Ashland, Wisconsin, United States, 54806
- Northwest Wisconsin Cancer Center
-
Burlington, Wisconsin, United States, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Chippewa Falls, Wisconsin, United States, 54729
- Marshfield Clinic-Chippewa Center
-
Eau Claire, Wisconsin, United States, 54701
- Marshfield Medical Center-EC Cancer Center
-
Fond Du Lac, Wisconsin, United States, 54937
- Aurora Health Center-Fond du Lac
-
Germantown, Wisconsin, United States, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, United States, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, United States, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, United States, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, United States, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Green Bay, Wisconsin, United States, 54301
- Bellin Memorial Hospital
-
Janesville, Wisconsin, United States, 53548
- Mercyhealth Hospital and Cancer Center - Janesville
-
Johnson Creek, Wisconsin, United States, 53038
- UW Cancer Center Johnson Creek
-
Kenosha, Wisconsin, United States, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, United States, 54601
- Gundersen Lutheran Medical Center
-
Ladysmith, Wisconsin, United States, 54848
- Marshfield Clinic - Ladysmith Center
-
Madison, Wisconsin, United States, 53792
- University of Wisconsin Carbone Cancer Center
-
Manitowoc, Wisconsin, United States, 54221
- Holy Family Memorial Hospital
-
Marinette, Wisconsin, United States, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marinette, Wisconsin, United States, 54143
- Saint Vincent Hospital Cancer Center at Marinette
-
Marshfield, Wisconsin, United States, 54449
- Marshfield Medical Center-Marshfield
-
Milwaukee, Wisconsin, United States, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, United States, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, United States, 53233
- Aurora Sinai Medical Center
-
Minocqua, Wisconsin, United States, 54548
- Marshfield Clinic-Minocqua Center
-
Mukwonago, Wisconsin, United States, 53149
- ProHealth D N Greenwald Center
-
New Richmond, Wisconsin, United States, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, United States, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oconto Falls, Wisconsin, United States, 54154
- Saint Vincent Hospital Cancer Center at Oconto Falls
-
Oshkosh, Wisconsin, United States, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, United States, 53406
- Aurora Cancer Care-Racine
-
Rice Lake, Wisconsin, United States, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, United States, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Sheboygan, Wisconsin, United States, 53081
- HSHS Saint Nicholas Hospital
-
Stevens Point, Wisconsin, United States, 54482
- Marshfield Medical Center-River Region at Stevens Point
-
Sturgeon Bay, Wisconsin, United States, 54235-1495
- Saint Vincent Hospital Cancer Center at Sturgeon Bay
-
Summit, Wisconsin, United States, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, United States, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, United States, 53188
- UW Cancer Center at ProHealth Care
-
Waukesha, Wisconsin, United States, 53188
- ProHealth Waukesha Memorial Hospital
-
Wausau, Wisconsin, United States, 54401
- Aspirus Regional Cancer Center
-
Wausau, Wisconsin, United States, 54401
- Marshfield Clinic-Wausau Center
-
Wauwatosa, Wisconsin, United States, 53226
- Aurora Cancer Care-Milwaukee West
-
West Allis, Wisconsin, United States, 53227
- Aurora West Allis Medical Center
-
Weston, Wisconsin, United States, 54476
- Marshfield Medical Center - Weston
-
Wisconsin Rapids, Wisconsin, United States, 54494
- Aspirus Cancer Care - Wisconsin Rapids
-
Wisconsin Rapids, Wisconsin, United States, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
-
Wyoming
-
Cheyenne, Wyoming, United States, 82001
- Cheyenne Regional Medical Center-West
-
Cody, Wyoming, United States, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, United States, 82801
- Welch Cancer Center
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Description
Inclusion Criteria:
- Patients must have histologically or cytologically confirmed extensive stage small cell lung cancer and must be a candidate for systemic therapy; NOTE: The extensive disease SCLC classification for this protocol includes all patients with disease sites not defined as limited stage; limited stage disease category includes patients with disease restricted to one hemithorax with regional lymph node metastases, including hilar, ipsilateral and contralateral mediastinal, and/or ipsilateral supraclavicular nodes; extensive disease patients are defined as those patients with extrathoracic metastatic disease, malignant pleural effusion, bilateral or contralateral supraclavicular adenopathy; patients with locally recurrent SCLC who are not eligible for curative intent chemoradiation are eligible
- Patients must have measurable disease based on Response Evaluation Criteria in Solid Tumors (RECIST) 1.1
- Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1
- Absolute neutrophil count >= 1,500/mm^3 (must be obtained =< 7 days prior to protocol registration)
- Platelets >= 100,000/mm^3 (must be obtained =< 7 days prior to protocol registration)
- Leukocytes >= 3000/mm^3 (must be obtained =< 7 days prior to protocol registration)
- Hemoglobin >= 9 g/dL (must be obtained =< 7 days prior to protocol registration)
- Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) (except subjects with Gilbert syndrome, who can have total bilirubin < 3 mg/dL) (must be obtained =< 7 days prior to protocol registration)
- Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT]) and alanine aminotransferase (ALT) (serum glutamic pyruvic transaminase [SGPT]) =< 3 X institutional upper limit of normal (ULN) (=< 5 X if liver function test [LFT] elevations due to known liver metastases) (must be obtained =< 7 days prior to protocol registration)
- Serum creatinine =< 1.5 x ULN or calculated creatinine clearance > 50 mL/min (using the Cockcroft-Gault formula) (must be obtained =< 7 days prior to protocol registration)
- Patients are eligible if central nervous system (CNS) metastases are adequately treated and neurological symptoms have returned to baseline or are controlled for at least 2 weeks prior to enrollment; in addition, subjects must be either off corticosteroids, or on a stable or decreasing dose of =< 10 mg daily prednisone (or equivalent); patients with untreated CNS metastases are eligible if they are not symptomatic and the lesions are less than 1 cm in size
- Patients cannot have had prior chemotherapy or biologic therapy for extensive stage small cell lung cancer for front line treatment; patients receiving prior whole brain radiation cannot register within 7 days after completion of radiation, and must have resolved adverse events attributed to radiation to =< grade 1; a 1-week washout is permitted for palliative radiation (=< 2 weeks of radiotherapy) to non-CNS disease
- Patients who have received prior chemoradiation treatment with chemotherapy regimen including cisplatin or carboplatin/etoposide for limited-stage SCLC are eligible if treated with curative intent at least 6 months since last treatment from diagnosis of extensive-stage SCLC
- Patients may not be receiving any other investigational agents while on study
- Women of childbearing potential (WOCBP) and males who are sexually active with WOCBP must use an accepted and effective method of contraception or abstain from sexual intercourse for at least one week prior to the start of treatment, and continue for 5 months after the last dose of protocol treatment for women of childbearing potential and 7 months after the last dose of protocol treatment for males who are sexually active with WOCBP
- No prior or current invasive malignancy (except non-melanomatous skin cancer, localized bladder and prostate cancer) unless disease free for a minimum of 2 years (for example, carcinoma in situ of the breast, oral cavity, or cervix are all permissible);
- No prior systemic treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA-4 antibody, or any other antibody or drug specifically targeting T-cell costimulation or immune checkpoint pathways;
- No patients with an active, known or suspected autoimmune disease and neuromuscular paraneoplastic syndromes including but not limited to myasthenia gravis, Lambert-Eaton myasthenic syndrome, limbic encephalitis, myositis, Guillain-Barre; subjects with type I diabetes mellitus, hypothyroidism only requiring hormone replacement, skin disorders (such as vitiligo, psoriasis, or alopecia) not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger are permitted to enroll
- No patients with a condition requiring systemic treatment with either corticosteroids (> 10 mg daily prednisone equivalent) or other immunosuppressive medications within 7 days of randomization; inhaled or topical steroids, and adrenal replacement steroid doses > 10 mg daily prednisone equivalent, are permitted in the absence of active autoimmune disease
- No patients with interstitial lung disease that is symptomatic or may interfere with the detection or management of suspected drug-related pulmonary toxicity
- No history of severe hypersensitivity reaction to any monoclonal antibody or allergy to study drug components
Exclusion Criteria:
- Patients must not have history of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab or other agents used in the study
- Women must not be pregnant or breast-feeding; because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with the agents used in this study, breastfeeding must be discontinued or the subject is not eligible for the study; all females of childbearing potential must have a blood test or urine study, with a minimum sensitivity 50 mlU/L or equivalent units of human chorionic gonadotropin (HCG), within 14 days prior to registration to rule out pregnancy; a female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e. has had menses at any time in the preceding 24 consecutive months)
- Patient must not have leptomeningeal disease
- Patients must NOT have uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, uncontrolled cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
- Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
- Any positive test for hepatitis B virus or hepatitis C virus indicating acute or chronic infection, patients are excluded
- Patients are ineligible if they received a live, attenuated vaccine within 4 weeks before randomization
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
|---|---|
|
Experimental: Arm A (nivolumab, CE)
Patients receive nivolumab IV over 30 minutes on day 1, carboplatin IV over 30-60 minutes on day 1 or cisplatin IV over 60-120 minutes on day 1, and etoposide IV over 60-120 minutes on days 1-3.
Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity.
Patients continue to receive nivolumab IV over 30 minutes every 2 weeks for up to 2 years.
|
Given IV
Other Names:
Given IV
Other Names:
Given IV
Other Names:
Given IV
Other Names:
|
|
Active Comparator: Arm B (CE)
Patients receive carboplatin IV over 30-60 minutes on day 1 or cisplatin IV over 60-120 minutes on day 1, and etoposide IV over 60-120 minutes on days 1-3.
Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity.
|
Given IV
Other Names:
Given IV
Other Names:
Given IV
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Progression-free Survival (PFS)
Time Frame: Every 6 weeks for 6 months, then every 8 weeks until 1 year, and then every 12 weeks until being off treatment or end of observation. Thereafter every 3 months if < 2 years from registration, every 6 months for years 2-3, and yearly up to 3 years 9 months
|
PFS is defined as the time from randomization to documented disease progression or death from any cause, whichever occurs first. Patients who have not experienced an event of interest by the time of analysis will be censored at the date they are last known to be alive and progression-free. Progression was evaluated using the revised Response Evaluation Criteria in Solid Tumors (RECIST) guideline (version 1.1). Progression was defined as appearance of one or more new lesions and/or unequivocal progression of existing non-target lesions, or at least a 20% increase in the sum of the diameters of target lesions, taking as reference the smallest sum on study (this includes the baseline sum if that is the smallest on study). In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of at least 5 mm. |
Every 6 weeks for 6 months, then every 8 weeks until 1 year, and then every 12 weeks until being off treatment or end of observation. Thereafter every 3 months if < 2 years from registration, every 6 months for years 2-3, and yearly up to 3 years 9 months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Overall Survival (OS)
Time Frame: Every 6 weeks for 6 months, then every 8 weeks until 1 year, and then every 12 weeks until off treatment or end of observation. Then every 3 months if < 2 years from registration, every 6 months for years 2-3, and yearly up to 3 years 9 months.
|
OS is defined as the time from maintenance randomization until death of any cause.
|
Every 6 weeks for 6 months, then every 8 weeks until 1 year, and then every 12 weeks until off treatment or end of observation. Then every 3 months if < 2 years from registration, every 6 months for years 2-3, and yearly up to 3 years 9 months.
|
|
Response Rate
Time Frame: Every 6 weeks for 6 months, then every 8 weeks until 1 year, and then every 12 weeks until being off treatment or end of observation. Thereafter every 3 months if < 2 years from registration, every 6 months for years 2-3, and yearly up to 3 years 9 months
|
Best overall response was evaluated using the revised Response Evaluation Criteria in Solid Tumors (RECIST) guideline (version 1.1). Response was defined as complete response (CR) or partial response (PR). CR: Disappearance of all lesions. Any pathological lymph nodes (whether target or non-target) must have reduction in short axis to < 10 mm. PR: At least a 30% decrease in the sum of the diameters of target lesions, taking as reference the baseline sum diameters. |
Every 6 weeks for 6 months, then every 8 weeks until 1 year, and then every 12 weeks until being off treatment or end of observation. Thereafter every 3 months if < 2 years from registration, every 6 months for years 2-3, and yearly up to 3 years 9 months
|
Other Outcome Measures
Outcome Measure |
Time Frame |
|---|---|
|
PD-L1 Expression Level
Time Frame: Assessed at baseline and 6 weeks
|
Assessed at baseline and 6 weeks
|
|
Association Between Circulating Tumor DNA and Clinical Outcome
Time Frame: circulating tumor DNA was assessed at baseline and 6 weeks; clinical outcomes were assessed every 3 months for patients < 2 years from registration, every 6 months if patient is 2-3 years from registration, and annually until 5 years from registration
|
circulating tumor DNA was assessed at baseline and 6 weeks; clinical outcomes were assessed every 3 months for patients < 2 years from registration, every 6 months if patient is 2-3 years from registration, and annually until 5 years from registration
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Ticiana A Leal, ECOG-ACRIN Cancer Research Group
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
May 2, 2018
Primary Completion (Actual)
February 16, 2022
Study Completion (Estimated)
December 31, 2024
Study Registration Dates
First Submitted
December 21, 2017
First Submitted That Met QC Criteria
December 21, 2017
First Posted (Actual)
December 26, 2017
Study Record Updates
Last Update Posted (Actual)
April 4, 2024
Last Update Submitted That Met QC Criteria
April 3, 2024
Last Verified
January 1, 2024
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Respiratory Tract Diseases
- Neoplasms by Histologic Type
- Neoplasms
- Lung Diseases
- Neoplasms by Site
- Neoplasms, Glandular and Epithelial
- Respiratory Tract Neoplasms
- Thoracic Neoplasms
- Carcinoma, Bronchogenic
- Bronchial Neoplasms
- Lung Neoplasms
- Carcinoma
- Small Cell Lung Carcinoma
- Carcinoma, Small Cell
- Molecular Mechanisms of Pharmacological Action
- Enzyme Inhibitors
- Antineoplastic Agents
- Tubulin Modulators
- Antimitotic Agents
- Mitosis Modulators
- Antineoplastic Agents, Phytogenic
- Topoisomerase II Inhibitors
- Topoisomerase Inhibitors
- Antineoplastic Agents, Immunological
- Dermatologic Agents
- Immune Checkpoint Inhibitors
- Keratolytic Agents
- Carboplatin
- Etoposide
- Etoposide phosphate
- Cisplatin
- Nivolumab
- Podophyllotoxin
Other Study ID Numbers
- NCI-2017-02367 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
- U10CA180820 (U.S. NIH Grant/Contract)
- EA5161 (Other Identifier: CTEP)
Plan for Individual participant data (IPD)
IPD Plan Description
Individual participant data may be made available upon request as per the ECOG-ACRIN Data Sharing Policy.
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Yes
Studies a U.S. FDA-regulated device product
No
product manufactured in and exported from the U.S.
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Extensive Stage Lung Small Cell Carcinoma
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Zhejiang Cancer HospitalRecruitingExtensive Stage Lung Small Cell CancerChina
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Mayo ClinicNational Cancer Institute (NCI)RecruitingPlatinum-Resistant Lung Small Cell Carcinoma | Platinum-Sensitive Lung Small Cell Carcinoma | Recurrent Extensive Stage Lung Small Cell Carcinoma | Refractory Extensive Stage Lung Small Cell CarcinomaUnited States
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Jonsson Comprehensive Cancer CenterPfizer; Translational Research in OncologyRecruitingRecurrent Extensive Stage Small Cell Lung Carcinoma | Refractory Extensive Stage Small Cell Lung CarcinomaUnited States
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University of WashingtonNational Cancer Institute (NCI); Imago BioSciences, Inc., a subsidiary of Merck...SuspendedExtensive Stage Lung Small Cell Carcinoma | Limited Stage Lung Small Cell CarcinomaUnited States
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SWOG Cancer Research NetworkNational Cancer Institute (NCI)RecruitingExtensive Stage Lung Small Cell Carcinoma | Limited Stage Lung Small Cell Carcinoma | Lung Small Cell CarcinomaUnited States, Canada, Korea, Republic of, Mexico
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M.D. Anderson Cancer CenterNational Cancer Institute (NCI)RecruitingStage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Extensive Stage Lung Small Cell CarcinomaUnited States
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Vanderbilt-Ingram Cancer CenterGenentech, Inc.RecruitingStage IV Lung Cancer | Extensive Stage Lung Small Cell CarcinomaUnited States
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Ohio State University Comprehensive Cancer CenterNational Institute on Aging (NIA)RecruitingStage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Stage IIIA Lung Cancer AJCC v8 | Stage IIIB Lung Cancer AJCC v8 | Extensive Stage Lung Small Cell Carcinoma | Unresectable Lung Non-Small Cell Carcinoma | Advanced Lung Non-Small Cell Carcinoma | Advanced... and other conditionsUnited States
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University of WashingtonAstraZenecaWithdrawnStage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Extensive Stage Lung Small Cell CarcinomaUnited States
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National Cancer Institute (NCI)Not yet recruitingStage IV Lung Cancer AJCC v8 | Extensive Stage Lung Small Cell Carcinoma
Clinical Trials on Carboplatin
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Eisai Inc.CompletedCancerUnited States, Austria, India
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Samyang Biopharmaceuticals CorporationCompleted
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NHS Greater Glasgow and ClydeCompletedOvarian Cancer | Fallopian Tube Cancer | Primary Peritoneal Cavity CancerUnited Kingdom, Australia, New Zealand
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Duke UniversityCompletedBrain and Central Nervous System TumorsUnited States, Canada
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National Cancer Institute (NCI)CompletedBreast Cancer | Ovarian CancerUnited States
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National Cancer Institute (NCI)Children's Oncology GroupCompletedBrain and Central Nervous System TumorsUnited States, Canada, Puerto Rico, Australia, Netherlands, New Zealand, Switzerland
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All India Institute of Medical Sciences, New DelhiCouncil of Scientific and Industrial Research, IndiaUnknownIntraocular RetinoblastomaIndia
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H. Lee Moffitt Cancer Center and Research InstituteNational Cancer Institute (NCI)CompletedUnspecified Adult Solid Tumor, Protocol SpecificUnited States
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Eli Lilly and CompanyCompletedLung NeoplasmsUnited States
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MEI Pharma, Inc.CompletedPeritoneal Neoplasms | Ovarian Cancer | Fallopian Tube CancerUnited States, Spain, Belgium, United Kingdom, Australia, Italy, Poland