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Search clinical trials for: Topoisomerase Inhibitors

Total 5557 results

NCT03100955

Unknown status

A Study of Standard Treatment +/- Apatinib in Extensive Stage Small Cell Lung Cancer

Conditions: Progression Free Survival
NCT00717938

Completed

A Study of Standard Treatment +/- Enoxaparin in Small Cell Lung Cancer

Conditions: Small Cell Lung Cancer
NCT00057837

Completed

Comparison of Two Combination Chemotherapy Regimens in Treating Patients With Extensive-Stage Small Cell Lung Cancer

Conditions: Extensive Stage Small Cell Lung Cancer
NCT02283359

Terminated

Selinexor in Combination With Irinotecan in Adenocarcinoma of Stomach and Distal Esophagus

Conditions: Esophageal Cancer; Gastric Cancer
NCT03045471

Not yet recruiting

The Efficacy and Safety of R-EPOCH and R-CHOP Regimen for Patients With AIDS Associated CD20+ Diffuse Large B Lymphoma

Conditions: To Evaluate the Efficacy and Safety of R-EPOCH and R-CHOP Regimen for Patients With AIDS Associated CD20+ Diffuse Large B Lymphoma
NCT03154996

Active, not recruiting

Chronic Convection Enhanced Delivery of Topotecan

Conditions: Gliomas
NCT01523457

Completed

Study of Modified FOLFIRINOX in Advanced Pancreatic Cancer

Conditions: Metastatic Pancreatic Cancer; Pancreatic Cancer
NCT01040312

Completed

An Observational Study of CPT-11 Plus Platinum Analogues Regimens and UGT1A1 Genotypes in Solid Tumors

Conditions: Small Cell Lung Cancer; Non-small Cell Lung Cancer; Cervical Cancer; Ovarian Cancer; Gastric Cancer (Inoperable and Recurrent)
NCT03735446

Terminated

Prexasertib in Combination With MEC in Relapsed/Refractory AML and High Risk MDS - a Phase I Trial

Conditions: Acute Myeloid Leukemia; Myelodysplastic Syndromes
NCT03597581

Recruiting

A Study of RGX-202-01 as a Single Agent and as Combination Therapy in Patients With Advanced Gastrointestinal Malignancies

Conditions: Gastrointestinal Cancer; Gastrointestinal Neoplasms; Colorectal Cancer; Colorectal Neoplasms; Colorectal Carcinoma; Gastric Cancer; Gastric Neoplasm; Pancreatic Cancer; Pancreatic Neoplasm
NCT01794104

Completed

Indenoisoquinoline LMP400 for Advanced Solid Tumors and Lymphomas

Conditions: Neoplasm; Lymphoma
NCT01051635

Completed

A Phase I Study of Indenoisoquinolines LMP400 and LMP776 in Adults With Relapsed Solid Tumors and Lymphomas

Conditions: Neoplasms; Lymphoma
NCT04095689

Not yet recruiting

TAC Chemotherapy and Pembrolizumab Plus Interleukin-12 Gene Therapy and L-NMMA in Triple Negative Breast Cancer

Conditions: Triple Negative Breast Cancer
NCT01550510

Terminated

Research Study of IV Vitamin C in Combination With Irinotecan vs Irinotecan Alone for Advanced Colorectal CA

Conditions: Stage IV Colorectal Cancer
NCT01039610

Withdrawn

A Single Center Four Part Study in Healthy Adult Subjects to Evaluate: the Safety, Tolerability and Pharmacokinetics of a Single Oral Dose and Repeat Escalating Oral Doses of GSK945237; the Effect of Linezolid on Hematology Safety Parameters; and the Effects of GSK945237 and Moxifloxacin on QTc.

Conditions: Infections, Bacterial
NCT02294682

Completed

A Dose-Ranging Study Evaluating the Efficacy, Safety, and Tolerability of GSK2140944 in the Treatment of Uncomplicated Urogenital Gonorrhea Caused by Neisseria Gonorrhoeae

Conditions: Gonorrhea
NCT01773109

Completed

Etirinotecan Pegol (NKTR-102) in NSCLC

Conditions: Metastatic Non Small Cell Lung Cancer; Recurrent Non Small Cell Lung Cancer
NCT04514497

Not yet recruiting

Testing the Addition of an Anti-cancer Drug, BAY 1895344, to Usual Chemotherapy for Advanced Stage Solid Tumors, With a Specific Focus on Patients With Small Cell Lung Cancer, Poorly Differentiated Neuroendocrine Cancer, and Pancreatic Cancer

Conditions: Metastatic Lung Small Cell Carcinoma; Metastatic Malignant Solid Neoplasm; Metastatic Neuroendocrine Carcinoma; Metastatic Pancreatic Adenocarcinoma; Stage III Lung Cancer AJCC v8; Stage III Pancreatic Cancer AJCC v8; Stage IIIA Lung Cancer AJCC v8; Stage IIIB Lung Cancer AJCC v8; Stage IIIC Lung Cancer AJCC v8; Stage IV Lung Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8; Unresectable Lung Small Cell Carcinoma; Unresectable Malignant Solid Neoplasm; Unresectable Neuroendocrine Carcinoma; Unresectable Pancreatic Adenocarcinoma
NCT01683149

Completed

Sorafenib and Topotecan in Refractory/Recurrent Pediatric Malignancies

Conditions: Solid Tumor
NCT01876446

Completed

Pegylated Irinotecan NKTR 102 in Treating Patients With Relapsed Small Cell Lung Cancer

Conditions: Recurrent Small Cell Lung Carcinoma
NCT03328884

Recruiting

Evaluation of the Efficacy and Safety of Nal-IRI for Progressing Brain Metastases in Breast Cancer Patients

Conditions: Breast Cancer Metastatic
NCT04073550

Not yet recruiting

Study of Anlotinib Hydrochloride Capsule in Subjects With Small Cell Lung Cancer

Conditions: Small Cell Lung Cancer
NCT02906059

Completed

Study of Irinotecan and AZD1775, a Selective Wee 1 Inhibitor, in RAS or BRAF Mutated, Second-line Metastatic Colorectal Cancer

Conditions: Metastatic Colorectal Cancer
NCT00252889

Completed

Doxil Topotecan Doublet Cancer Study

Conditions: Small Cell Lung Cancer; Pancreatic Cancer; Head and Neck Cancer; Gastric Cancer; Esophageal Cancer
NCT02487095

Recruiting

Trial of Topotecan With VX-970 (M6620), an ATR Kinase Inhibitor, in Small Cell Cancers and Extrapulmonary Small Cell Cancers

Conditions: Carcinoma, Non-Small -Cell Lung; Ovarian Neoplasms; Small Cell Lung Carcinoma; Uterine Cervical Neoplasms; Carcinoma, Neuroendocrine; Extrapulmonary Small Cell Cancer