Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity (SELECT)

March 31, 2024 updated by: Novo Nordisk A/S

SELECT - Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity

The researchers are doing the study to see if semaglutide may reduce the risk of having cardiovascular events in patients with overweight or obesity and with prior cardiovascular disease. The participant will either get semaglutide (active medicine) or placebo ("dummy" medicine). Which treatment the participants get is decided by chance. The participant's chance of getting semaglutide or placebo is the same. The participant will get the study medicine in a pen. The participants will need to use the pen to inject the study medicine in a skinfold once a week. The study will last for about 2.5 to 5 years. Participants will have up to 25 clinic visits with the study doctor.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

17609

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Name: Novo Nordisk
Phone Number: (+1) 866-867-7178
Email: clinicaltrials@novonordisk.com

Study Locations

Algeria
- - Algiers, Algeria, 16000
    - Cardiology department CHU Mustapha Pacha. Algiers
  - Algiers, Algeria, 16000
    - Centre National De la Médecine du Sport
  - Algiers, Algeria, 16000
    - CHU Issad Hassani, Beni Messous, Cardiology department
  - Algiers, Algeria, 16040
    - CHU - Hussein dey Cardiology department Nafissa Hamoud
  - Oran, Algeria, 31000
    - Cardiology department, Benaouda Benzerdjeb CHU Oran
Argentina
- - Caba, Argentina, C1093AAS
    - Fundacion Favaloro
  - Caba, Argentina, C1430EGF
    - Clinica Adventista Belgrano
  - Caba, Argentina, C1061AAS.
    - Centro de Investigación y Prevención Cardiovascular
  - Caba, Argentina, C1426EGQ
    - Centro Médico MEDEOS
  - Caba, Argentina, C1430CKE
    - Glenny Corp. S.A
  - Caba, Argentina, C1440AAD
    - Medical Center of Diabetes and Nutrition
  - Corrientes, Argentina, W3400AMZ
    - Instituto de Cardiologia de Corrientes
  - Córdoba, Argentina, X5003DCE
    - Instituto Médico DAMIC
  - Rosario, Argentina, S2000
    - Sanatorio Plaza
- City Of Buenos Aires
  - Caba, City Of Buenos Aires, Argentina, C1180AAX
    - Sanatorio Güemes
Australia
- Australian Capital Territory
  - Garran, Australian Capital Territory, Australia, 2605
    - The Canberra Hospital_Garran
- New South Wales
  - Gosford, New South Wales, Australia, 2250
    - Gosford Hospital
  - Liverpool, New South Wales, Australia, 2170
    - Liverpool Hospital
  - Merewether, New South Wales, Australia, 2291
    - Hunter Diabetes Centre
- Queensland
  - Milton, Queensland, Australia, 4064
    - Advara HeartCare
  - Milton, Queensland, Australia, 4064
    - Core Research Centre
  - Wollongabba, Queensland, Australia, 4102
    - Cholesterol Care Australia
- South Australia
  - Adelaide, South Australia, Australia, 5000
    - Royal Adelaide Hospital Cardiovascular Clinical Trials
  - Elizabeth Vale, South Australia, Australia, 5112
    - Lyell McEwin Hospital
- Victoria
  - Clayton, Victoria, Australia, 3168
    - Monash Cardiovascular Research Centre
  - Geelong, Victoria, Australia, 3220
    - Geelong Cardiology Research Unit
  - Heidelberg Heights, Victoria, Australia, 3081
    - Austin Health, Metabolic Disorders Centre
- Western Australia
  - Joondalup, Western Australia, Australia, 6027
    - HeartCare WA (Joondalup)
Austria
- - Graz, Austria, 8036
    - Universitätsklinik für Innere Medizin
  - Innsbruck, Austria, 6020
    - Univ.-Klinik für Innere Medizin I
  - Salzburg, Austria, 5020
    - LKH Salzburg Universitätsklinikum
  - Wien, Austria, 1090
    - Universitätsklinikum AKH Wien
  - Wien, Austria, 1030
    - Klinik Landstraße
  - Wien, Austria, 1130
    - Klinik Hietzing
  - Wien, Austria, 1060
    - Ordination Dr. Hanusch
Belgium
- - Aalst, Belgium, 9300
    - Algemeen Stedelijk Ziekenhuis - Aalst - Interventional Cardiology
  - Bonheiden, Belgium, 2820
    - Imeldaziekenhuis - Bonheiden - Department of Endocrinology
  - Bruxelles, Belgium, 1070
    - CUB Hôpital Erasme_Brussels_1
  - Genk, Belgium, 3600
    - Ziekenhuis Oost-Limburg AV - Cardiology
  - Gent, Belgium, 9000
    - UZ Gent - Cardiology
  - Gent, Belgium, 9000
    - UZ Gent_Gent_4
  - Hasselt, Belgium, 3500
    - Jessa Ziekenhuis - Hasselt - Cardiology
Brazil
- - Rio de Janeiro, Brazil, 20241-180
    - Instituto Brasil de Pesquisa Clinica
- Bahia
  - Salvador, Bahia, Brazil, 40170130
    - Cárdio Pulmonar da Bahia
- Distrito Federal
  - Brasilia, Distrito Federal, Brazil, 70390-700
    - Hospital do Coração do Brasil
- Minas Gerais
  - Uberlândia, Minas Gerais, Brazil, 38400-500
    - Eurolatino Medical Research Center
- Parana
  - Curitiba, Parana, Brazil, 80030-480
    - Cline Research Center
  - Curitiba, Parana, Brazil, 80730-150
    - Núcleo de Pesquisa Clínica S/S
- Rio Grande Do Sul
  - Passo Fundo, Rio Grande Do Sul, Brazil, 99010-080
    - Hospital Sao Vicente de Paulo
- Santa Catarina
  - Blumenau, Santa Catarina, Brazil, 89020-430
    - AngioCor Blumenau
- Sao Paulo
  - Campinas, Sao Paulo, Brazil, 13060-080
    - Instituto de Pesquisa Clínica de Campinas
  - São José do Rio Preto, Sao Paulo, Brazil, 15090-000
    - CIP Centro Integrado de Pesquisas do Hospital de Base
  - São Paulo, Sao Paulo, Brazil, 01228-000
    - CPQuali Pesquisa Clínica Ltda
  - São Paulo, Sao Paulo, Brazil, 01228-200
    - CPCLIN - Centro de Pesquisas Clínicas
  - São Paulo, Sao Paulo, Brazil, 04012-909
    - Instituto Dante Pazzanese de Cardiologia
  - São Paulo, Sao Paulo, Brazil, 05403-000
    - Departamento de Gastroenterologia - HCFMUSP
  - São Paulo, Sao Paulo, Brazil, 05403-000
    - Instituto do Coração - HCFMUSP
Bulgaria
- - Dimitrovgrad, Bulgaria, 6400
    - Medical Centre Diamedical-2013
  - Lukovit, Bulgaria, 5770
    - MHAT Lukovit, Department of Internal Diseases
  - Pazardzhik, Bulgaria, 4400
    - "MHAT - Pazardzhik" AD, Second Department of Internal Diseas
  - Pleven, Bulgaria, 5800
    - "UMBAL-Dr. Georgi Stranski" EAD, First Clinic of cardiology
  - Plovdiv, Bulgaria, 4002
    - "UMHAT "Sveti Georgi" EAD
  - Razgrad, Bulgaria, 7200
    - Medical centre Razgrad OOD
  - Sofia, Bulgaria, 1309
    - "MHAT "NCH" EAD, Cardiology clinic, Noninvasive diag. dep.
  - Sofia, Bulgaria, 1309
    - "MHAT "NCH" EAD, Clinic of Cardiology, Depart. of Cardiology
  - Sofia, Bulgaria, 1407
    - "Acibadem City Clinic MHAT Tokuda" EAD,Cardiology department
  - Sofia, Bulgaria, 1407
    - "Acibadem City Clinic UMHAT" EOOD, Sofia, Cardiology clinic
  - Sofia, Bulgaria, 1431
    - "Diagnostic - Consulting Center Aleksandrovska" EOOD
  - Sofia, Bulgaria, 1431
    - "UMHAT "Aleksandrovska" EAD, Cardiology clinic
  - Sofia, Bulgaria, 1527
    - "UMHAT "Tsaritsa Yoanna-ISUL"" EAD, Clinic of Cardiology
  - Sofia, Bulgaria, 1606
    - "UMHATEM N.I. Pirogov" EAD
  - Sofia, Bulgaria, 1750
    - "UMHAT "Sveta Anna" Sofia" AD, Clinic of Cardiology
  - Varna, Bulgaria, 9002
    - "Diagnostic - Consulting Center "Ekvita"" EOOD
Canada
- - Quebec, Canada, G1V 4G5
    - Institut universitaire de cardiologie
- Alberta
  - Calgary, Alberta, Canada, T2T 5C7
    - University of Calgary
  - Calgary, Alberta, Canada, T2V 4J2
    - C-endo Diab Endo Clin Calgery
  - Sherwood Park, Alberta, Canada, T8H 0N2
    - Synergy Wellness Clinic
- New Brunswick
  - Moncton, New Brunswick, Canada, E1G 1A7
    - G.A. Research Associates Ltd.
- Ontario
  - Burlington, Ontario, Canada, L7M 4Y1
    - Manna Research Inc. (Burlington N)
  - Cambridge, Ontario, Canada, N1R 6V6
    - Cambridge Cardiac Care Centre
  - London, Ontario, Canada, N6A 4V2
    - St. Joseph's Health Care
  - Nepean, Ontario, Canada, K2J 4A7
    - Manna Research Ottawa
  - North York, Ontario, Canada, M6B 3H7
    - North York Diagn & Cardiac Ctr
  - Oshawa, Ontario, Canada, L1J 2K1
    - Dr. James Cha
  - Peterborough, Ontario, Canada, K9J 0B2
    - Kawartha Cardiology Clinical Trials
  - Port Perry, Ontario, Canada, L9L 1L9
    - Medical Associates of Port Perry
  - Scarborough, Ontario, Canada, M1B 4Z8
    - HHI Research Inc.
  - Stoney Creek, Ontario, Canada, L8J 3W2
    - Manna Research Stoney Creek
  - Thunder Bay, Ontario, Canada, P7A 4V7
    - The Port Arthur Clinic Research Program
  - Toronto, Ontario, Canada, M9W 4L6
    - Manna Research Inc._Toronto
- Quebec
  - Brossard, Quebec, Canada, J4Z 2K9
    - ViaCar Recherche Clinique Inc
  - Levis, Quebec, Canada, G6W 0M5
    - Manna Research Quebec
  - Mirabel, Quebec, Canada, J7J 2K8
    - Manna Research Mirabel
  - Montreal, Quebec, Canada, H1T 3Y7
    - Clinique Sante Cardio MC
  - Montreal, Quebec, Canada, H2W 1R7
    - IRCM
  - Montreal, Quebec, Canada, H4A 3T2
    - Applied Med Inf Res
  - Pointe-Claire, Quebec, Canada, H9R 4S5
    - Centricity Res Pointe-Claire
  - Québec, Quebec, Canada, G1V 4W2
    - Clin des Mal Lipid de Quebec
  - Sherbrooke, Quebec, Canada, J1H 5N4
    - Centre de recherche du CHUS
  - St-Marc-des-Carrières, Quebec, Canada, G0A 4B0
    - Ctr Méd. et pro d l'Ost d port
  - Terrebonne, Quebec, Canada, J6V 2H2
    - Centre de santé et de services
Colombia
- - Barranquilla, Colombia, 80020
    - Clinica de la Costa
  - Barranquilla, Colombia, 080020
    - Fundacion del Caribe para la Investigacion Biomedica-BIOS
  - Medellin, Colombia, 050021
    - Centro de Investigacion Clinica Avanzada y Multidisciplinari
  - Medellin, Colombia, 050034
    - CardiovidCentro Cardiovascular Colombiano ClinicaSantaMaria
- Antioquia
  - Medellin, Antioquia, Colombia, 050021
    - Rodrigo Botero S.A.S
- Atlántico
  - Barranquilla, Atlántico, Colombia, 080001
    - IPS Centro Cientifico Asistencial Jose Luis Accini SAS
- Santander
  - Bucaramanga-piedecuesta, Valle Del Menzuli - Santander, Santander, Colombia, 681012
    - Unidad de Estudios Clínicos de la Fundación Cardiovascular de Colombia
Croatia
- - Osijek, Croatia, 31 000
    - Klinicki bolnicki centar Osijek
  - Rijeka, Croatia, 51000
    - KBC Rijeka, Zavod za kardiomiopatije
  - Zagreb, Croatia, 10000
    - Klinicka bolnica Sveti Duh
  - Zagreb, Croatia, 10000
    - KBC "Sestre milosrdnice", Kardiologija
  - Zagreb, Croatia, 10000
    - KBC Zagreb, Klinika za bolesti srca i krvnih zila
- Grad Zagreb
  - Zagreb, Grad Zagreb, Croatia, 10000
    - Poliklinika Solmed
- Krapinsko Zagorska County
  - Krapinske Toplice, Krapinsko Zagorska County, Croatia, 49217
    - Specijalna bolnica Krapinske Toplice - Kardiologija
Czechia
- - Broumov, Czechia, 550 01
    - Edumed Broumov
  - Chomutov, Czechia, 430 02
    - Ordinace pro choroby srdce
  - Hradec Kralove, Czechia, 500 05
    - Fakultni nemocnice Hradec Kralove_Hradec Kralove_0
  - Jihlava, Czechia, 586 33
    - Nemocnice Jihlava Kardiologie
  - Liberec, Czechia, 460 63
    - Kardiologické centrum
  - Policka, Czechia, 572 01
    - Policska nemocnice
  - Praha 4, Czechia, 140 00
    - Endocare
  - Praha 8, Czechia, 181 00
    - ResTrial
  - Slany, Czechia, 274 01
    - Nemocnice Slany Kardiologie
  - Svitavy, Czechia, 568 25
    - Svitavska nemocnice Kardiologie
  - Tabor, Czechia, 39003
    - Vseobecna kardiologicka ambulance
- Czech Republic
  - Praha 2, Czech Republic, Czechia, 128 08
    - Fakultni poliklinika
Denmark
- - Aalborg, Denmark, 9000
    - Aalborg Universitetshospital Kardiologisk Afdeling
  - Aarhus N, Denmark, 8200
    - Aarhus Universitetshospital, Skejby Hjertesygdomme
  - Herning, Denmark, 7400
    - Regionshospitalet Gødstrup, Hjertesygdomme
  - Hvidovre, Denmark, 2650
    - Hvidovre Hospital Hjertemedicinsk
  - Svendborg, Denmark, 5700
    - Kardiologisk Odense & Svendborg
- Region Hovedstaden
  - Hellerup, Region Hovedstaden, Denmark, 2900
    - Herlev Og Gentofte Hospital
Finland
- - Jyväskylä, Finland, 40620
    - StudyCor
  - Kuopio, Finland, 70210
    - Health Step Finland Oy
  - Lahti, Finland, 15850
    - Päijät-Häme Central hospital
  - Oulu, Finland, 90220
    - OYS Sisätautien tutkimusyksikkö
  - Seinäjoki, Finland, 60220
    - Seinäjoen keskussairaala
  - Tampere, Finland, 33520
    - TAYS Sydänsairaala
  - Turku, Finland, 20520
    - TYKS Sydänkeskus
France
- - Besançon, France, 25030
    - CHRU Besançon
  - Bondy, France, 93143
    - Hôpital Jean Verdier
  - Corbeil Essonnes, France, 91106
    - Centre Hospitalier Sud Francilien
  - DIJON cedex, France, 21079
    - Centre Hospitalier Universitaire de Dijon-Hopital Le Bocage
  - DIJON cedex, France, 21079
    - Chu Du Bocage
  - La Tronche, France, 38700
    - Centre Hospitalier Universitaire Grenoble Alpes-Site Nord Michallon-1
  - Le Coudray, France, 28630
    - Les Hopitaux de Chartres-Hopital Louis Pasteur
  - Narbonne, France, 11100
    - Centre Hospitalier de Narbonne
  - Nice, France, 06000
    - Chu de Nice
  - Paris, France, 75015
    - Hôpital Européen Georges Pompidou
  - Paris, France, 75013
    - Aphp-Hopital La Pitie Salpetriere-2
  - Paris, France, 75015
    - Ap-Hp-Hopital Europeen Georges Pompidou
  - Paris Cedex 18, France, 75877
    - Ap-Hp-Hopital Bichat-Claude Bernard-2
  - Pessac, France, 33600
    - Centre Hospitalier Universitaire de Bordeaux-Hopital Haut Leveque-2
  - Saint Herblain, France, 44800
    - Centre Hospitalier Universitaire de Nantes-Hopital Nord Laennec-1
  - Strasbourg, France, 67091
    - Les Hopitaux Universitaires de Strasbourg-Hopital Civil-2
  - Venissieux, France, 69200
    - Groupe Hospitalier Mutualiste Des Portes Du Sud
Germany
- - Aachen, Germany, 52074
    - Universitaetsklinikum Aachen AöR
  - Bad Homburg, Germany, 61348
    - Kardiologische Praxis
  - Berlin, Germany, 10629
    - emovis GmbH
  - Berlin, Germany, 10117
    - Klinische Forschung Berlin (kfgn)
  - Berlin, Germany, 12627
    - Synexus Berlin
  - Bochum, Germany, 44787
    - Synexus Bochum
  - Dresden, Germany, 01069
    - Klinische Forschung Dresden
  - Dresden, Germany, 01277
    - Hausaerztlich-Kardiologisches MVZ Am Felsenkeller GmbH
  - Elsterwerda, Germany, 04910
    - Zentrum fuer klinische Studien Suedbrandenburg GmbH
  - Essen, Germany, 45136
    - InnoDiab Forschung GmbH
  - Frankfurt, Germany, 60389
    - MVZ CCB Frankfurt Und Main-Taunus GbR
  - Frankfurt, Germany, 60313
    - Synexus Frankfurt
  - Friedrichsthal, Germany, 66299
    - Denger, Friedrichsthal
  - Hamburg, Germany, 20253
    - Klinische Forschung Hamburg
  - Hamburg, Germany, 22607
    - Wendisch/Dahl Hamburg
  - Hannover, Germany, 30159
    - Klinische Forschung Hannover
  - Karlsruhe, Germany, 76137
    - Chevts
  - Kassel, Germany, 34121
    - Appel
  - Leipzig, Germany, 04107
    - AmBeNet GmbH
  - Leipzig, Germany, 04103
    - Universitätsklinikum Leipzig, Endokrinologie und Nephrologie
  - Ludwigshafen, Germany, 67059
    - Die Praxis am Ludwigsplatz
  - Lübeck, Germany, 23562
    - Universitätsklinikum Schleswig-Holstein
  - Oldenburg in Holstein, Germany, 23758
    - RED-Institut für medizinische Forschung und Fortbildung GmbH
  - Pirna, Germany, 01796
    - Dr. Axthelm Christoph, Pirna
  - Saint Ingbert-Oberwürzbach, Germany, 66386
    - Zentrum für klinische Studien Alexander Segner
  - Schkeuditz, Germany, 04435
    - Steindorf, Schkeuditz
  - Schwerin, Germany, 19055
    - Klinische Forschung Schwerin
  - Villingen-Schwenningen, Germany, 78048
    - Jacob, Villingen-Schwenningen
  - Wangen, Germany, 88239
    - Zentrum für klinische Studien Allgäu Oberschwaben
  - Wermsdorf, Germany, 04779
    - Al-Zoebi
  - Witten, Germany, 58455
    - Forschungszentrum Ruhr KliFoCenter GmbH, Dr. med. Kahrmann
Greece
- - Athens, Greece, 17674
    - Onassis Cardiac Surgery Center
  - Athens, Greece, GR-11527
    - "Laiko" General Hospital of Athens
  - Athens, Greece, GR-15125
    - Iatriko Athinon (Athens Medical Canter)
  - Athens, Greece, GR-14233
    - Konstantopouleio G.H. of Athens, "Agia Olga"
  - Athens, Greece, GR-15123
    - "Hygeia" General Hospital of Athens
  - Athens, Greece, GR-11527
    - Hippokration Hospital
  - Athens, Greece, GR-11528
    - Alexandra General Hospital, Therapeutic Clinic
  - Chios, Greece, GR82100
    - General Hospital of Chios "Skilitsio"
  - Haidari-Athens, Greece, GR-12462
    - University Hospital of Athens ATTIKON
  - Ioannina, Greece, 45500
    - University General Hospital of Ioannina,Internal Medicine
  - Lamia, Greece, GR35100
    - General Hospital of Lamia
  - Larissa, Greece, GR-41110
    - Univ Gen Hospital Larisa, Internal Medicine Clinic
  - Thessaloniki, Greece, GR-57001
    - "Thermi" Private Hosital
  - Thessaloniki, Greece, GR-54636
    - AHEPA General University Hospital
Hungary
- - Debrecen, Hungary, H-4032
    - Debreceni Egyetem Klinikai Központ Belgyógyászati Klinika
  - Gyöngyös, Hungary, 3200
    - Bugát Pál Kórház
  - Szombathely, Hungary, H-9700
    - Markusovszky Egyetemi Oktatokorhaz
- Bács-Kiskun Vármegye
  - Baja, Bács-Kiskun Vármegye, Hungary, 6500
    - Lausmed Kft.
- Csongrád-Csanád
  - Szeged, Csongrád-Csanád, Hungary, H-6725
    - Szegedi Tudomanyegyetem St Györgyi Albert Klinikai Központ
- Zala Megye
  - Zalaegerszeg, Zala Megye, Hungary, 8900
    - Léda Platán Magánklinika
India
- - Bangalore, India, 560 099
    - Narayana Hrudayalya Institute of Cardiac Sciences
  - Bangalore, India, 560034
    - St John's Medical College and Hospital
  - New Delhi, India, 110060
    - Sir Ganga Ram Hospital
  - New Delhi, India, 110005
    - Dr. BL Kapur Memorial Hospital
- Andhra Pradesh
  - Vijayawada, Andhra Pradesh, India, 520008
    - Ramesh Hospitals
- Delhi
  - New Delhi, Delhi, India, 110062
    - Batra Hospital and Medical Research Center
- Gujarat
  - Ahmedabad, Gujarat, India, 380054
    - Apex Heart Institute
  - Ahmedabad, Gujarat, India, 380060
    - CIMS- Care Institute of Medical Sciences
  - Surat, Gujarat, India, 395002
    - Nirmal Hospital Pvt. Ltd.
  - Surat, Gujarat, India, 395001
    - Shri B. D. Mehta Mahavir Heart Institute
  - Surat, Gujarat, India, 395001
    - Unicare heart institute and research centre
- Haryana
  - Gurgaon, Haryana, India, 122001
    - Medanta - The Medicity Multi-Speciality Hospital, Gurugram
- Karnataka
  - Bangalore, Karnataka, India, 560069
    - Sri Jayadeva Institute of Cardiovascular Sciences & Research
  - Bengaluru, Karnataka, India, 560034
    - St John's Medical College Hospital
  - Manipal, Karnataka, India, 576104
    - Department of Medicine - Kasturba Hospital
- Maharashtra
  - Aurangabad, Maharashtra, India, 431010
    - Kamalnayan Bajaj Hospital
  - Mumbai, Maharashtra, India, 400022
    - Lokmanya Tilak Municipal Medical College & General Hospital
  - Mumbai, Maharashtra, India, 400012
    - Seth GS medical college and KEM Hospital
  - Mumbai, Maharashtra, India, 400050
    - Holy Family Hospital and Medical Research Centre
  - Nagpur, Maharashtra, India, 440012
    - Shri Krishna Hrudayalaya & Critical Care Centre
  - Nagpur, Maharashtra, India, 440010
    - Arneja Heart & Multispeciality Hospital
  - Nashik, Maharashtra, India, 422005
    - Vijan Hospital & Research Centre
  - Pune, Maharashtra, India, 411004
    - Deenanath Mangeshkar Hospital and Research Centre
  - Pune, Maharashtra, India, 411001
    - Grant Medical Foundation
- New Delhi
  - Delhi, New Delhi, India, 110002
    - Maulana Azad Medical College
  - New Dehli, New Delhi, India, 110029
    - All India Institute of Medical Sciences
  - New Dehli, New Delhi, India, 110029
    - VMMC & Safdarjung Hospital
- Punjab
  - Ludhiana, Punjab, India, 141001
    - Dayanand Medical College & Hospital
- Rajasthan
  - Bikaner, Rajasthan, India, 334003
    - SP Medical College
- Tamil Nadu
  - Chennai, Tamil Nadu, India, 600037
    - The Madras Medical Mission
  - Coimbatore, Tamil Nadu, India, 641037
    - G Kuppuswamy Naidu Memorial Hospital
  - Vellore, Tamil Nadu, India, 632004
    - Christian Medical College Hospital, Vellore
- Telangana
  - Hyderabad, Telangana, India, 500020
    - Guru Nanak CARE Hospitals
- Telengana
  - Hyderabad, Telengana, India, 500 012
    - Osmania General Hospital
- Uttar Pradesh
  - Lucknow, Uttar Pradesh, India, 226003
    - Gandhi Memorial Hospital- King George's Medical University
- West Bengal
  - Kolkata, West Bengal, India, 700027
    - B M Birla Heart Research Centre
Ireland
- - Dublin, Ireland, A96 D628
    - The Heartbeat Trust
  - Dublin, Ireland, D04 T6F4
    - St Vincent's Private Hospital
  - Dublin, Ireland, D24NR0A
    - Tallaght Hospital - Cardiology
  - Mallow, Ireland, P51Y8EC
    - Mallow Primary Healthcare Centre
- Leinster
  - Dublin, Leinster, Ireland, D07 XAO9
    - Mater Miscericordiae Hospital
  - Dublin, Leinster, Ireland, DUBLIN 15
    - Connolly Hospital
Israel
- - Beer Sheva, Israel, 84101
    - Outpatient Diabetes Clinic Soroka MC
  - Haifa, Israel, 31096
    - Diabetes and obesity center of excellence, Rambam MC
  - Jerusalem, Israel, 91120
    - Diabetes Unit Hadassah Ein Karem MC
  - Jerusalem, Israel, 91120
    - Hadassah Ein Kerem MC - Cardio
  - Kfar Saba, Israel, 44281
    - Clinical Research Unit Meir Medical Center
  - Nahariya, Israel, 22100
    - Institute of Diabetes, Western Galilee MC Nahariya
  - Petah-Tikva, Israel, 49372
    - Rabin Medical Center - Hasharon Hospital, Dept. D
  - Rehovot, Israel, 76100
    - Kaplan MC
  - Tel Aviv, Israel, 6423906
    - Cardio Vascular Research Center Sourasky MC
  - Tel Hashomer, Israel, 52621
    - Endrocrinolgy Clinic - Sheba Medical Center
  - Tel Hashomer, Israel, 5265601
    - Sheba Medica Center - Clinical Research Unit
  - Tel-Aviv, Israel, 64239
    - Institute of Endocrinology, metabolism and hypertension
Italy
- - Bergamo, Italy, 24127
    - AO Papa Giovanni XXIII USS Dietologia Clinica
  - Bologna, Italy, 40138
    - A. O. Universitaria S.ORSOLA-MALPIGHI - U. O. Endocrinologia
  - Catania, Italy, 95122
    - ARNAS Ospedale Garibaldi
  - Chieti Scalo, Italy, 66100
    - Università degli studi G. D'Annunzio Chieti Pescara - CAST
  - Como, Italy, 22042
    - Ospedale di San Fermo della Battaglia
  - Cona - Ferrara, Italy, 44124
    - Azienda Osp-Univ Ferrara-Dip Scienze Mediche-Endocrinologia
  - Firenze, Italy, 50134
    - AOU Careggi Dipartimento Medico Geriatrico SOD Diabetologia
  - Genova, Italy, 16132
    - U.O.D. Dietetica e Nutrizione Clinica
  - Napoli, Italy, 80131
    - Azienda Ospedaliera Universitaria Federico II di Napoli
  - Padova, Italy, 35128
    - Azienda Ospedaliera di Padova Clin.Med.3
  - Palermo, Italy, 90127
    - Unità Funzionale di nutrizione clinica cod 58.01.3
  - Pavia, Italy, 27100
    - IRCCS Fondazione "S. Maugeri" U.O. Medicina Interna ed Endo
  - Pisa, Italy, 56124
    - Azienda Ospedaliero Universitaria Pisana Ospedale Cisanello
  - Roma, Italy, 00133
    - UOC di Medicina Interna - Centro Medico dell'Obesità
  - Rome, Italy, 00168
    - Policlinico Universitario AGemelli DH Patologie dell'Obesità
  - Rozzano (MI), Italy, 20089
    - Ist.Clinico Humanitas Endocrinologia e Malattie del ricambio
  - San Donato Milanese (MI), Italy, 20097
    - Centro di Alta Spec. Diet., Educ. Alim. e Prev. Cardio Metab
  - Savigliano (CN), Italy, 12038
    - Osp. Santissima Annunziata ASL CN1 Endocrinol. Diabetol.
  - Sesto San Giovanni (MI), Italy, 20099
    - IRCCS Multimedica
  - Siena, Italy, 53100
    - A.O.U. Senese Policlinico "Le Scotte" , U.O.C. Diabetologia
  - Torino, Italy, 10126
    - A.O.U. Città della Salute e della Scienza di Torino
- LT
  - Latina, LT, Italy, 04100
    - Ospedale Santa Maria Goretti - UOD Diabetologia
- MI
  - San Donato Milanese (MI), MI, Italy, 20097
    - Centro di Alta Spec. Diet., Educ. Alim. e Prev. Cardio Metab
- RM
  - Roma, RM, Italy, 00128
    - Pol. Uni. Campus Biomedico UOC Endocrinologia e Diabetologia
Japan
- - Adachi-ku, Tokyo, Japan, 123-0845
    - Seiwa Clinic
  - Asahikawa, Hokkaido, Japan, 078-8237
    - Toyooka Chuo Hospital
  - Bunkyo-ku, Tokyo, Japan, 113-8655
    - The Univ. of Tokyo Hp., Dept. of Cardiovascular Medicine
  - Chiba, Japan, 271-0077
    - New Tokyo Heart Clinic_Matsudo-shi, Chiba,
  - Chikushino-shi, Fukuoka, Japan, 818-8516
    - Fukuokaken Saiseikai Futsukaichi Hospital_Cardiovascular Medicine
  - Ehime, Japan, 790-0024
    - Ehime Prefectural Central Hospital
  - Funabashi-shi, Chiba, Japan, 274-8503
    - Chiba Tokushukai Hospital
  - Gifu-city, Gifu, Japan, 500-8384
    - Gifu Heart Center
  - Hirakata-shi, Osaka, Japan, 573-0153
    - Hirakata kohsai Hospital
  - Hiroshima-shi, Hiroshima, Japan, 732-0057
    - Medical Corporation JR Hiroshima Hospital
  - Kagoshima-shi, Kagoshima, Japan, 892-0828
    - Hiroshi Yamaguchi Clinic
  - Kanagawa, Japan, 235-0045
    - H.E.C Science Clinic
  - Kasugai-shi, Aichi, Japan, 486-8510
    - Kasugai Municipal Hospital
  - Kawaguchi-shi, Saitama, Japan, 332-0012
    - Sugiura Clinic
  - Kitakyushu-shi, Fukuoka, Japan, 805-8508
    - Steel Memorial Yawata Hospital
  - Kochi-shi, Kochi, Japan, 780-8522
    - Chikamori Hospital
  - Kumamoto-shi, Kumamoto, Japan, 861-4193
    - Saiseikai Kumamoto Hospital
  - Kyoto, Japan, 611-0041
    - Uji Tokushukai Medical Center
  - Kyoto-shi, Kyoto, Japan, 600-8558
    - Koseikai Takeda Hospital
  - Kyoto-shi,Kyoto, Japan, 601-1495
    - Ijinkai Takeda General Hospital, Cardiovascular Medicine
  - Kyoto-shi,Kyoto, Japan, 601-1495
    - Ijinkai Takeda General Hospital, Neurosurgery
  - Matsuyama-shi, Ehime, Japan, 790-0062
    - Medical Corporation Matsuyama-heartcenter Yotsuba Circulatio
  - Miyagi, Japan, 983-0039
    - Shinden Higashi Clinic_Miyagi
  - Moriyama-shi, Shiga, Japan, 524-8524
    - Shiga General Hospital
  - Nagoya-shi, Aichi, Japan, 454-8502
    - Nagoya Ekisaikai Hospital
  - Naha-shi, Okinawa, Japan, 902-8511
    - Naha City Hospital
  - Okawa-shi, Fukuoka, Japan, 831-0016
    - Takagi hospital, Internal Medicine
  - Okayama-shi, Okayama, Japan, 701-1192
    - Okayama Medical Center
  - Osaka, Japan, 569-1045
    - Takatsuki Red Cross Hospital
  - Osaka-city, Osaka, Japan, 530-0001
    - Specified Med.Corp.Watanabeigakukai Sakurabashi Watanabe Hp.
  - Saga-shi, Saga, Japan, 849-8501
    - Saga University Hospital, Department of Cardiology
  - Sapporo-shi, Hokkaido, Japan, 004-0004
    - Shinsapporo Seiryou Hospital, Intenal Medicine
  - Sapporo-shi, Hokkaido, Japan, 062-0003
    - Hanaoka Seishu Memorial Hospital
  - Sapporo-shi, Hokkaido, Japan, 064-8570
    - Medical corporation Sanseikai Miyanomori Memorial Hospital
  - Sendai-shi, Miyagi, Japan, 980-0873
    - Sendai Kousei Hospital_Sendai-shi, Miyagi
  - Shinjuku-ku, Tokyo, Japan, 162-8655
    - National Center for Global Health and Medicine
  - Takamatsu-shi, Kagawa, Japan, 760-0073
    - Japan Community Health care Organization Ritsurin Hospital
  - Takamatsu-shi, Kagawa, Japan, 760-8557
    - Kagawa Prefectural Central Hospital, Cardiovascular Medicine
  - Takamatsu-shi, Kagawa, Japan, 760-8557
    - Kagawa Prefectural Central Hospital
  - Takasaki-shi, Gunma, Japan, 370-3513
    - Kan-etsu chu-oh Hospital
  - Tokorozawa-shi, Saitama, Japan, 356-1142
    - Tokorozawa Heart Center
  - Tokorozawa-shi,Saitama, Japan, 359-1141
    - Saino Clinic
  - Tokyo, Japan, 103-0027
    - Tokyo-Eki Center-building Clinic
  - Tokyo, Japan, 192-0918
    - Minamino Cardiovascular Hospital
  - Tokyo, Japan, 104-0031
    - Fukuwa Clinic
  - Tokyo, Japan, 140-8522
    - Tokyo Shinagawa Hospital Social Medical Corporation Association Tokyokyojuno-kai
  - Wako-city, Saitama, Japan, 351-0102
    - National Hospital Organization Saitama National Hospital
  - Yanagawa-shi, Fukuoka, Japan, 832-0059
    - Nagata Hospital
  - Yokosuka-shi, Kanagawa, Japan, 238-856
    - Yokosuka General Hospital Uwamachi, Cardiology
Latvia
- - Daugavpils, Latvia, LV5401
    - Ari Med
  - Liepaja, Latvia, LV-3414
    - Meissana Ltd
  - Ogre, Latvia, LV-5001
    - Teterovska practice
  - Riga, Latvia, LV-1002
    - Stradini Cardiology
  - Riga, Latvia, LV-1011
    - Medical Centre Pulss 5
  - Riga, Latvia, LV1011
    - Adoria
  - Riga, Latvia, LV1012
    - Health Centre-4
  - Ventspils, Latvia, LV3601
    - Ziemelkurzeme Regional Hospital
Malaysia
- - Alor Gajah, Malaysia, 78300
    - Klinik Kesihatan Masjid Tanah
  - Alor Setar, Malaysia, 05460
    - Hospital Sultanah Bahiyah
  - Kota Bharu, Malaysia, 15586
    - Hospital Raja Perempuan Zainab II
  - Kota Samarahan, Malaysia, 94300
    - Sarawak Heart Centre
  - Kuala Lumpur, Malaysia, 59100
    - University Malaya Medical Centre
  - Kuala Lumpur, Malaysia, 50400
    - National Heart Institute
  - Kuantan, Malaysia, 25100
    - Hospital Tengku Ampuan Afzan
  - Putrajaya, Malaysia, 62250
    - Hospital Putrajaya
  - Sabah, Malaysia, 88300
    - Hospital Queen Elizabeth II
- Kelantan
  - Kota Bharu, Kelantan, Malaysia, 16150
    - Hospital Universiti Sains Malaysia
- Pahang
  - Kuantan, Pahang, Malaysia, 25100
    - Hospital Tengku Ampuan Afzan
- Perak
  - Seri Manjung, Perak, Malaysia, 32040
    - Hospital Seri Manjung
- Sarawak
  - Kota Samarahan, Sarawak, Malaysia, 94300
    - Sarawak Heart Centre
- Selangor
  - Sungai Buloh, Selangor, Malaysia, 47000
    - University Technology MARA (UiTM) - Puncak Alam
Mexico
- - Aguascalientes, Mexico, 20230
    - Centro de Investigación Cardiometabólica de Aguascalientes
  - Durango, Mexico, 34000
    - Lahoja Asociación para la Investigación y Farmacovigilancia
- Coahuila
  - Torreon, Coahuila, Mexico, 27000
    - CIMAB SA de CV
- Jalisco
  - Guadalajara, Jalisco, Mexico, 44670
    - Centro de Investigacion Clinica Endocrinologica de Jalisco
- México, D.F.
  - Ciudad de Mexico, México, D.F., Mexico, 03100
    - Hospital General Regional 1 "Dr. Carlos Mac Gregor Sánchez"
  - Ciudad de Mexico, México, D.F., Mexico, 14080
    - Instituto Nacional de Cardiologia Ignacio Chavez
- Nuevo León
  - Monterrey, Nuevo León, Mexico, 64460
    - Unidad Biomedica Avanzada Monterrey
  - Monterrey, Nuevo León, Mexico, 64460
    - Hospital Universitario Dr. José Eleuterio González_Monterrey
- San Luis Potosi
  - San Luis Potosí, San Luis Potosi, Mexico, 78200
    - Centro de atención e investigación cardiovascular del Potosí
- Sinaloa
  - Culiacán, Sinaloa, Mexico, 80230
    - Centro para el Desarrollo de la Medicina y la Asistencia
Netherlands
- - Apeldoorn, Netherlands, 7334 DZ
    - Gelre Ziekenhuizen Apeldoorn
  - Breda, Netherlands, 4818 CK
    - Amphia Ziekenhuis
  - Deventer, Netherlands, 7416 SE
    - Deventer Ziekenhuis
  - Groningen, Netherlands, 9713 GZ
    - UMC Groningen
  - Leeuwarden, Netherlands, 8934 AD
    - Medisch Centrum Leeuwarden
  - Leiderdorp, Netherlands, 2353 GA
    - Alrijne Leiderdorp
  - Roosendaal, Netherlands, 4708 AE
    - Bravis Ziekenhuis
  - Rotterdam, Netherlands, 3045 PM
    - Franciscus Gasthuis en Vlietland
  - Sneek, Netherlands, 8601 ZR
    - D & A Research B.V.
  - Tiel, Netherlands, 4002 WP
    - Ziekenhuis Rivierenland Tiel
Norway
- - Bergen, Norway, 5021
    - Haukeland Universitetssykehus
  - Hamar, Norway, 2317
    - Falck Norge AS
  - Lillehammer, Norway, 2609
    - Sykehuset Innlandet Lillehammer
  - Nordbyhagen, Norway, 1474
    - Akershus universitetssykehus
  - Oslo, Norway, 0586
    - Oslo universitetssykehus Aker
  - Oslo, Norway, 0372
    - Rikshospitalet - Kardiologisk forskning
  - Oslo, Norway, 0450
    - Oslo universitetssykehus HF Ullevål
  - Tønsberg, Norway, 3117
    - Senter for sykelig overvekt i Helse Sør-Øst
  - Ålesund, Norway, 6017
    - Ålesund Sjukehus - Hjertemedisinsk poliklinikk
Poland
- - Gdansk, Poland, 80-546
    - Centrum Badan Klinicznych PI-House
  - Gdansk, Poland, 80-286
    - Poradnia Kardiologiczna Jaroslaw Jurowiecki
  - Krakow, Poland, 31-271
    - UniCardia & UniMedica & UniEstetica
  - Krakow, Poland, 30-033
    - Grazyna Pulka Specjalistyczny Osrodek "All-Med"
  - Lodz, Poland, 90-338
    - Centrum Terapii Wspolczesnej
  - Lomza, Poland, 18-404
    - Klimed Lomza
  - Lowicz, Poland, 99-400
    - ETG Lowicz
  - Poznan, Poland, 61-485
    - Centrum Medyczne HCP Sp. z o.o.
  - Pulawy, Poland, 24-100
    - KO-MED Centra Kliniczne Sp. z o.o.
  - Szczecin, Poland, 71-531
    - Gabinety Lekarskie LabMed
  - Warszawa, Poland, 02-507
    - Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych i Administracji
  - Warszawa, Poland, 00-416
    - Przychodnia Lekarzy Specjalistow Serce
  - Zamosc, Poland, 22-400
    - Ko-Med Nova Sp.zo.o. oddział w Zamosciu
- Lodzkie
  - Skierniewice, Lodzkie, Poland, 96-100
    - Clinmedica Research sp. z o.o.
- Lubelskie
  - Lublin, Lubelskie, Poland, 20-044
    - NZOZ "CenterMed Lublin" Sp. z o.o.
- Masovian
  - Siedlce, Masovian, Poland, 08-110
    - ETG Siedlce
  - Warsaw, Masovian, Poland, 02-677
    - Etg Warszawa
- Podlaskie
  - Bialystok, Podlaskie, Poland, 15-481
    - Kresmed Sp. z o. o.
- Podlaskie Voivodeship
  - Bialystok, Podlaskie Voivodeship, Poland, 15-281
    - Gabinet Leczenia Otylosci i Chorob Dietozaleznych
- Pomorskie
  - Gdynia, Pomorskie, Poland, 81-338
    - Centrum Medyczne Pratia Gdynia
  - Gdynia, Pomorskie, Poland, 81-338
    - PRATIA Centrum Medyczne
- Wielkopolskie Voivodeship
  - Poznan, Wielkopolskie Voivodeship, Poland, 60-589
    - Centrum Zdrowia Metabolicznego
Portugal
- - Almada, Portugal, 2805-267
    - Hospital Garcia de Orta
  - Coimbra, Portugal, 3000-459
    - Centro Hospitalar e Universitário de Coimbra
  - Lisboa, Portugal, 1500-650
    - Hospital da Luz
  - Lisboa, Portugal, 1649-035
    - Centro Hospitalar Lisboa Norte
  - Matosinhos, Portugal, 4464-513
    - Unidade Local de Saúde de Matosinhos
  - Porto, Portugal, 4200-319
    - Centro Hospitalar de São João
Puerto Rico
- - Trujillo Alto, Puerto Rico, 00976
    - San Miguel Medical
Romania
- - Bacau, Romania, 600238
    - Minimed S.R.L.
  - Brasov, Romania, 500283
    - Centrul Medical de Diagnostic si Tratament Ambulatoriu Neomed
  - Bucharest, Romania, 011025
    - Sana Monitoring SRL
  - Bucharest, Romania, 010507
    - Sc Nicodiab Srl
  - Bucharest, Romania, 010825
    - "Carol Davila" Military Emergency Hospital
  - Bucharest, Romania, 031818
    - SC Eco-Diagnosis SRL
  - Bucuresti, Romania, 011863
    - Institutul National de Endocrinologie C.I. Parhon
  - Buzau, Romania, 120203
    - S.C. Medcon S.R.L
  - Galati, Romania, 800001
    - S.C Milena Sante SRL
  - Galati, Romania, 800291
    - SC Diamed Obesity SRL
  - Iasi, Romania, 700547
    - SC Consultmed SRL
  - Iasi, Romania, 700687
    - SC Cardiomed SRL
  - Pascani, Romania, 700502
    - Centrul Medical Bella Praxis
  - Pascani, Romania, 705200
    - Bella Praxis S.R.L.
  - Ploiesti, Romania, 100561
    - S.C. Dianutrilife Medica S.R.L.
  - Satu Mare, Romania, 440055
    - County Emergency Hospital Satu Mare
  - Sibiu, Romania, 550371
    - SC Gensan SRL, Policlinica ASTRA
- Bihor
  - Oradea, Bihor, Romania, 410025
    - SC Grand Med SRL
  - Oradea, Bihor, Romania, 410151
    - S.C. Endodigest S.R.L.
- Calaras
  - Clarasi, Calaras, Romania, 910103
    - SC Ames Research Center SRL
- Cluj
  - Cluj Napoca, Cluj, Romania, 400349
    - S.C. Centrul Medical Unirea S.R.L.
- Dolj
  - Craiova, Dolj, Romania, 200515
    - S.C. Top Diabet Srl
- Hunedoara
  - Deva, Hunedoara, Romania, 330084
    - County Hospital Deva
- Maramures
  - Baia Mare, Maramures, Romania, 430222
    - CMI Dr Pop Lavinia
- Mures
  - Targu Mures, Mures, Romania, 540142
    - Sc Mediab Srl
- Timis
  - Timisoara, Timis, Romania, 300736
    - 3rd Clinic for Nutrition-Spitalulul Județean de Urgenta
Russian Federation
- - Arkhangelsk, Russian Federation, 163001
    - Volosevich First City Clinical Hospital
  - Barnaul, Russian Federation, 656045
    - City Hospital #5
  - Barnaul, Russian Federation, 656024
    - Reg. State Budget Healthc. Inst. Regional Clinical Hospital
  - Barnaul, Russian Federation, 656055
    - RBSHI "Altay Regional Cardiology Dispensary"
  - Belgorod, Russian Federation, 308007
    - Belgorod regional clinical hospital of the St. Ioasaph
  - Ekaterinburg, Russian Federation, 620026
    - Urals State Medical University
  - Ivanovo, Russian Federation, 153012
    - Cardiological dispensary
  - Kazan, Russian Federation, 420010
    - KSFMU, Inrereginal Clinical Diagnostic center
  - Kemerovo, Russian Federation, 650002
    - Institute of Complex Problems of Cardio-Vascular Diseases
  - Moscow, Russian Federation, 121552
    - National Medical Research Center of Cardiology
  - Moscow, Russian Federation, 127486
    - Federal Bureau for Medical and Social Expertise
  - Moscow, Russian Federation, 109369
    - Medical Center CAPITAL-HEALTH
  - Moscow, Russian Federation, 111539
    - Moscow City Clinical Hospital #15
  - Moscow, Russian Federation, 117292
    - Friendship University of Russia
  - Moscow, Russian Federation, 119991
    - Moscow State University n.a. M.V. Lomonosov
  - Moscow, Russian Federation, 123182
    - City Clinical Hospital №52
  - Moscow, Russian Federation, 129128
    - PHI "Central Clinical Hospital RZD- Medicine"
  - Moscow, Russian Federation, 129327
    - Moscow City Clinical Hospital n.a. A.K. Eramishantseva
  - Novosibirsk, Russian Federation, 630099
    - LLC Reafan
  - Novosibirsk, Russian Federation, 630005
    - LLC RC Medical
  - Novosibirsk, Russian Federation, 630099
    - Limited Law Company "Healthy Family" Medicine Center"
  - Novosibirsk, Russian Federation, 630117
    - Scientific Research Institute of neuroscience and Medicine
  - Orenburg, Russian Federation, 460018
    - Orenburg Regional Clinical Hospital
  - Penza, Russian Federation, 440052
    - Penza Regional Clinical Hospital named after N.N. Burdenko
  - Rostov-on-Don, Russian Federation, 344068
    - Rostov State Medical University_Rostov-on-Don
  - Saint Petersburg, Russian Federation, 192283
    - SPb SBHI City Outpatient clinic #109
  - Saint-Petersburg, Russian Federation, 197110
    - Consultative & Diagnostic Center with a Outpatient Hospital
  - Saint-Petersburg, Russian Federation, 190013
    - City policlinic #28
  - Saint-Petersburg, Russian Federation, 190121
    - Joint Stock Company "Modern Medical Technologies"
  - Saint-Petersburg, Russian Federation, 191119
    - SPb SBHI City Outpatient clinic #37
  - Saint-Petersburg, Russian Federation, 194156
    - Limited Liability Company "Energiya Zdoroviya"
  - Saint-Petersburg, Russian Federation, 194358
    - SPb SBHI City polyclinic #117
  - Saint-Petersburg, Russian Federation, 197022
    - FSPbSMU n.a. Academic I.P. Pavlov
  - Saint-Petersburg, Russian Federation, 197762
    - Saint-Petersburg "City Policlinic # 74"
  - Saint-Petersburg, Russian Federation, 199226
    - Astarta Clinic LLC
  - Saint-Petersburg, Pushkin, Russian Federation, 196601
    - SPb SBHI City Hospital #38 n.a. N.A. Semashko
  - Samara, Russian Federation, 443070
    - Regional Clinical cardiological dispensary n.a. Polyakov
  - Sochi, Russian Federation, 354057
    - City Hospital #4, Sochi
  - St. Petersburg, Russian Federation, 194354
    - SPb SBHI City Multifield Hospital #2
  - Syktyvkar, Russian Federation, 167981
    - SAHI of Komi Republic "Consultative Diagnostic Center"
  - Tomsk, Russian Federation, 634012
    - Tomsk National Research Medical Center of the RAS
  - Tomsk, Russian Federation, 634041
    - Tomsk Regional Clinical Hospital
  - Tomsk, Russian Federation, 634050
    - Siberian State Medical University_Tomsk
  - Tumen, Russian Federation, 625023
    - Tumen State Medical University - RIMBB
  - Tver, Russian Federation, 170036
    - Regional Clinical Hospital of Tver
  - Ulianovsk, Russian Federation, 432063
    - Ulianovsk Regional Clinical Hospital
  - Voronezh, Russian Federation, 394018
    - Voronezh Regional Clinical Consultive-diagnostic Centre
  - Yaroslavl, Russian Federation, 150003
    - Solovyov Clinical Emergency Hospital
- Russia
  - Tumen, Russia, Russian Federation, 625023
    - Tumen State Medical University
Serbia
- - Belgrade, Serbia, 11000
    - Clinical centre of Serbia, Clinic for cardiology
  - Belgrade, Serbia, 11000
    - Endocrinology, Diabetes and Metabolism Diseases Clinic
  - Belgrade, Serbia, 11000
    - Clinical Centre of Serbia, Emergency Centre, Department of Cardiology
  - Belgrade, Serbia, 11000
    - Emergency Internal Medicine Clinic
  - Belgrade, Serbia, 11000
    - Special Hospital "Sveti Sava"
- Vojvodina
  - Novi Sad, Vojvodina, Serbia, 21000
    - Clin. Centre Vojvodina, Clin. endocr., diab. and met. dis.
South Africa
- Eastern Cape
  - Port Elizabeth, Eastern Cape, South Africa, 6001
    - Phoenix Pharma
- Free State
  - Bloemfontein, Free State, South Africa, 9301
    - Josha Research
  - Bloemfontein, Free State, South Africa, 9301
    - Iatros International
  - Bloemfontein, Free State, South Africa, 9301
    - Cardiology Research_Bloemfontein
- Gauteng
  - Alberton, Gauteng, South Africa, 1450
    - Cardiology Clinical Research
  - Centurion, Gauteng, South Africa, 0157
    - Dr Iftikhar Osman Ebrahim
  - Germiston, Gauteng, South Africa, 1401
    - CRISMO
  - Johannesburg, Gauteng, South Africa, 2193
    - Wits Clinical Research
  - Johannesburg, Gauteng, South Africa, 2013
    - Wits Bara Clinical Trial Site
  - Johannesburg, Gauteng, South Africa, 2157
    - Tickerdoc Research (Pty) LTD
  - Lenasia, Gauteng, South Africa, 1827
    - Lenasia Clinical Trial Centre
  - Lenasia, Gauteng, South Africa, 1827
    - Dr Moosa's Rooms
  - Pretoria, Gauteng, South Africa, 0184
    - Synexus Watermeyer Clinical Research Centre
  - Pretoria, Gauteng, South Africa, 0183
    - Jongaie Research
  - Pretoria, Gauteng, South Africa, 0186
    - Clinical Trial Systems (CTC)
  - Roodepoort, Gauteng, South Africa, 1724
    - Roodepoort Medicross Clinical Research Centre
- KwaZulu-Natal
  - Durban, KwaZulu-Natal, South Africa, 4091
    - Dr Jugnundan's Rooms
- Western Cape
  - Cape Town, Western Cape, South Africa, 7130
    - Synexus Helderberg Clinical Research Centre
  - Cape Town, Western Cape, South Africa, 7700
    - UCT Lung institute
  - Cape Town, Western Cape, South Africa, 7405
    - Dr S Dawood
  - Cape Town, Western Cape, South Africa, 7500
    - Dr Corbett
  - Cape Town, Western Cape, South Africa, 7500
    - Tread Research (Pty)Ltd
  - Kuilsriver, Western Cape, South Africa, 7580
    - Cape Town Medical Research Centre
  - Paarl, Western Cape, South Africa, 7646
    - Paarl Research Centre
  - Worcester, Western Cape, South Africa, 6850
    - Clinical Projects Research
Spain
- - Almeria, Spain, 04009
    - Centro Periférico de Especialidades Bola Azul
  - La Coruña, Spain, 15006
    - Complejo Hospitalario Universitario A Coruña
  - Madrid, Spain, 28009
    - Hospital Gregorio Marañon
  - Madrid, Spain, 28046
    - Hospital Universitario La Paz
  - Madrid, Spain, 28034
    - Hospital Ramón y Cajal
  - Málaga, Spain, 29010
    - Hospital Clínico Virgen de la Victoria
  - Palma de Mallorca, Spain, 07198
    - Hospital Son Llatzer
  - Sevilla, Spain, 41009
    - Hospital Virgen de la Macarena
  - Sevilla, Spain, 41010
    - Hospital Infanta Luisa
  - Sevilla, Spain, 41003
    - Clínica Nuevas Tecnologías en Diabetes y Endocrinología
  - Valencia, Spain, 46026
    - Hospital La Fe - Endocrinología y Nutrición
Sweden
- - Göteborg, Sweden, 413 45
    - Lundberglab for Diab Research
  - Kristianstad, Sweden, 291 85
    - Centralsjukhuset, Kristianstad
  - Lund, Sweden, 222 21
    - Clemenstorgets Hjärtmottagning
  - Stockholm, Sweden, 171 76
    - Karolinska Universitetssjukhuset Solna,FOU Tema Hjärta Kärl
  - Örebro, Sweden, 703 62
    - Enheten för Kliniska Studier (EKS), Örebro
  - Östersund, Sweden, 831 83
    - Hjärtenheten
Taiwan
- - Hsinchu City, Taiwan, 300
    - Hsinchu MacKay Memorial Hospital
  - Kaohsiung City, Taiwan, 82445
    - E-DA Hosiptal
  - New Taipei City, Taiwan, 25160
    - MacKay Memorial Hospital-Tamsui Branch
  - Taipei, Taiwan, 100
    - National Taiwan University Hospital
  - Taoyuan City, Taiwan, 333
    - Chang Gung Memorial Hospital Linkou
Thailand
- - Bangkok, Thailand, 10330
    - King Chulalongkorn Memorial Hospital_Bangkok
  - Bangkok, Thailand, 10400
    - Phramongkutklao Hospital-cardio
  - Bangkok, Thailand, 10400
    - Phramongkutklao Hospital-neuro
  - Bangkok, Thailand, 10400
    - Ramathibodi Hospital-Cardiovascular metabolic Center
  - Bangkok, Thailand, 10700
    - Siriraj Hospital_Bangkok_1
  - Chiang Mai, Thailand, 50200
    - Maharaj Nakorn Chiang Mai Hospital-cardio
  - Khon kaen, Thailand, 40002
    - Srinakarind Hospital-Division of Cardiology
- Mueang Chiang Mai District
  - Chiang Mai, Mueang Chiang Mai District, Thailand, 50200
    - Maharaj Nakorn Chiang Mai Hospital
- Pathumthani
  - Klong Luang, Pathumthani, Pathumthani, Thailand, 12120
    - Thammasat University Hospital
Turkey
- - Adana, Turkey, 01250
    - Baskent Universitesi Adana
  - Adana, Turkey, 01330
    - Cukurova University School of Medicine Balcali Hospital
  - Ankara, Turkey, 06100
    - Hacettepe Universitesi Tip Fakultesi Hastanesi
  - Ankara, Turkey, 06010
    - Gulhane Egitim Arastirma Hastanesi
  - Antalya, Turkey, 07058
    - Akdeniz University Tip Fakultesi Hastanesi
  - Aydin, Turkey, 09010
    - Adnan Menderes Universitesi Uygulama ve Arastirma Hastanesi
  - Eskisehir, Turkey, 26040
    - Eskisehir Osmangazi University-Cardio
  - Gaziantep, Turkey, 27070
    - Gaziantep Universitesi Tip Fakultesi Hastanesi
  - Istanbul, Turkey, 34010
    - Koc University Hospital
  - Istanbul, Turkey, 34371
    - Seyrantepe Hamidiye Etfal Egitim ve Arastirma Hastanesi
  - Istanbul, Turkey, 34390
    - Istanbul Universitesi Istanbul Tip Fakultesi - Endokrinoloji
  - Istanbul, Turkey, 34400
    - TC SB Ist.İl Sag.Müd.Prof.Dr.Cemil Tascioglu Sehir Hastanesi
  - Istanbul, Turkey, 34752
    - Fatih Sultan Mehmet Hastanesi
  - Istanbul, Turkey, 34760
    - Umraniye Egitim ve Arastirma Hastanesi
  - Istanbul, Turkey, 34899
    - T.C. Saglik Bakanligi Pendik Egitim ve Arastirma Hastanesi
  - Izmir, Turkey, 35180
    - Izmir Tepecik Training and Research Hospital
  - Izmir, Turkey, 35100
    - Ege University School of Medicine, Cardiology Department
  - Izmir, Turkey, 35340
    - Dokuz Eylul University School of Medicine, Cardiology
  - Kayseri, Turkey, 38039
    - Erciyes University Cardiology
  - Mersin, Turkey, 33343
    - Mersin University Cardiology
  - Sivas, Turkey, 58140
    - Cumhuriyet University School of Medicine-Cardiology
Ukraine
- - Chernivtsi, Ukraine, 58000
    - CMI City Clinical Hospital #3
  - Kharkiv, Ukraine, 61002
    - CNPI "Kharkiv City Clinical Hospital #27"
  - Kharkiv, Ukraine, 61039
    - NI of Therapy na LT Malaya of NAMSU - Chr. Non-Communicable
  - Kyiv, Ukraine, 01023
    - Oleksandrivska Clinical Hospital - cardio rehabilitation dep
  - Kyiv, Ukraine, 01135
    - Medical Center of LLC 'Harmoniya Krasy'
  - Kyiv, Ukraine, 02091
    - Medical Center 'Ok!Clinic+' of II of Clinical Studies LLC
  - Kyiv, Ukraine, 02660
    - Kyiv City Clinical Hospital of Emergency Care - Infarction
  - Kyiv, Ukraine, 03049
    - Clinical Hosp on the railway line №2 branch PHC JSC Ukrzaliz
  - Kyiv, Ukraine, 03151
    - MD Strazheska Institute of Cardiology of NAMSU - Resuscitati
  - Kyiv, Ukraine, 04053
    - Kyiv Regional Hospital
  - Lviv, Ukraine, 79059
    - City Clinical Emergency Hospital - Cardiology department
  - Odesa, Ukraine, 65025
    - Odesa Regional Clinical Hospital
  - Odesa, Ukraine, 65059
    - Odessa Clinical Railway Hospital - Outpatient department
  - Vinnytsia, Ukraine, 21000
    - City Clinical Hospital #1 - Therapy department
  - Vinnytsia, Ukraine, 21018
    - Vinnytsia Regional Clinical Hospital - Cardiology department
  - Zhytomyr, Ukraine, 10002
    - Central City Hospital #1 - Scientific-Research center
  - Zhytomyr, Ukraine, 10002
    - Zhytomir Regional Clinical Hospital - Cardio-Arrhytm. centre
United Kingdom
- - Addlestone, United Kingdom, KT15 2BH
    - Crouch Oak Family Practice
  - Airdrie, United Kingdom, ML6 0JS
    - Stroke Trials Office
  - Antrim, United Kingdom, BT42 2RL
    - Antrim Area Hospital
  - Axbridge, United Kingdom, BS26 2BJ
    - Axbridge & Wedmore Medical Practice
  - Basingstoke, United Kingdom, RG24 9GT
    - Bermuda Practice
  - Bexhill-on-Sea, United Kingdom, TN40 1JJ
    - Sea Road Surgery
  - Birmingham, United Kingdom, B9 5SS
    - Birmingham Heartlands Hospital
  - Blackpool, United Kingdom, FY3 7EN
    - Layton Medical Centre
  - Bollington, United Kingdom, SK10 5JH
    - Bollington Medical Centre
  - Bradford-on-Avon, United Kingdom, BA15 1DQ
    - The Health Centre
  - Bristol, United Kingdom, BS10 5NB
    - Southmead Hospital
  - Cardiff, United Kingdom, CF5 4AD
    - Ely Bridge Surgery
  - Chertsey, United Kingdom, KT16 0PZ
    - St Peters Hospital, Chertsey
  - Chester, United Kingdom, CH2 1UL
    - Countess Of Chester NHS Foundation Trust
  - Coventry, United Kingdom, CV2 2DX
    - WISDEM Centre
  - Denmark Hill, London, United Kingdom, SE5 9RS
    - Kings College Hospital
  - Dundee, United Kingdom, DD1 9SY
    - Ninewells Hospital
  - Exeter, United Kingdom, EX2 5DW
    - Royal Devon University Healthcare NHS Foundation Trust
  - Harrogate, North Yorkshire, United Kingdom, HG2 7SX
    - Harrogate District Hospital
  - Harrow, United Kingdom, HA1 3UJ
    - Department Of Cardiac Research
  - High Wycombe, United Kingdom, HP11 2TT
    - Wycombe General Hospital
  - Hull, United Kingdom, HU3 2JZ
    - Hull Royal Infirmary
  - Leicester, United Kingdom, LE3 9QP
    - Cardiology
  - Lincoln, United Kingdom, LN2 5QY
    - Lincoln County Hospital
  - Liverpool, United Kingdom, L9 7AL
    - University Hospital Aintree
  - London, United Kingdom, SE1 9RT
    - Guys Hospital
  - London, United Kingdom, W12 0HS
    - Imperial College London
  - Manchester, United Kingdom, M8 5RB
    - Diabetes Centre North Manchester General Hospital
  - Middlesbrough, United Kingdom, TS4 3BW
    - Cardio Research
  - Plymouth, United Kingdom, PL6 8DH
    - University Dept of Medicine, Derriford Hospital, Plymouth
  - Rhyl, United Kingdom, LL18 1DA
    - Clarence Medical Centre
  - Sandbach, United Kingdom, CW11 1EQ
    - Ashfields Primary Care Centre
  - Somerset, United Kingdom, BA21 4AT
    - Clinical Research Unit
  - Southampton, United Kingdom, SO30 3JB
    - Moorgreen Hospital
  - Stevenage, United Kingdom, SG1 4AB
    - Lister Hospital
  - Sunderland, United Kingdom, SR4 7TP
    - Sunderland Royal Hospital
  - Taunton, United Kingdom, TA1 5DA
    - Musgrove Park Hospital
  - Torquay, United Kingdom, TQ2 7AA
    - Cardiology Department
  - Truro, United Kingdom, TR1 3LJ
    - Royal Cornwall Hospital (Treliske)
  - Wishaw, United Kingdom, ML2 0DP
    - University Hospital Wishaw
- South Yorkshire
  - Rotherham, South Yorkshire, United Kingdom, S65 1DA
    - Clifton Medical Centre
- West Sussex
  - Chichester, West Sussex, United Kingdom, PO19 6SE
    - St. Richards Hospital
United States
- Alabama
  - Birmingham, Alabama, United States, 35209
    - Central Alabama Research
  - Birmingham, Alabama, United States, 35294
    - Univ of Alabama Birmingham
  - Montgomery, Alabama, United States, 36106
    - Healthscan Clinical Trials,LLC.
- Arizona
  - Glendale, Arizona, United States, 85306
    - Synexus Clinical Research US, Inc./Tatum
  - Glendale, Arizona, United States, 85308
    - Synexus Clinical Research
  - Phoenix, Arizona, United States, 85050
    - Synexus Cln Rsrch /Cnt Phoenix Med C
- California
  - Beverly Hills, California, United States, 90211
    - National Heart Institute Cal
  - Costa Mesa, California, United States, 92627
    - FDRC
  - Covina, California, United States, 91723
    - Valley Clinical Trials
  - La Jolla, California, United States, 92037
    - Scripps Whittier Diabetes Inst
  - Lancaster, California, United States, 93534
    - First Valley Medical Group
  - Lomita, California, United States, 90717
    - Torrance Clin Res Inst, Inc.
  - Long Beach, California, United States, 90822
    - Long Beach VA Healthcare System
  - Los Angeles, California, United States, 90010
    - Angel City Research, Inc.
  - Los Angeles, California, United States, 90073
    - VAGLAHS Clinical Research Center (CRC)
  - Moreno Valley, California, United States, 92555
    - Riverside University Health System Medical Center
  - Northridge, California, United States, 91325
    - Valley Clinical Trials, Inc.
  - Palm Springs, California, United States, 92262
    - Desert Oasis Hlthcr Med Group
  - Pomona, California, United States, 91766
    - Western University of Health Sciences
  - Quartz Hill, California, United States, 93536
    - Quartz Hill Walk-in Medical Group, inc.
  - San Diego, California, United States, 92111
    - San Diego Family Care
  - San Diego, California, United States, 92108
    - Triwest Research Associates
  - San Mateo, California, United States, 94401
    - Mills-Peninsula Medical Center
  - San Ramon, California, United States, 94583
    - NorCal Endocrinology and Internal Medicine
  - Spring Valley, California, United States, 91978
    - Encompass Clinical Research_Spring Valley
  - Torrance, California, United States, 90502
    - Lundquist Inst-Biomed Innovtn
  - Vista, California, United States, 92083
    - Synexus Clinical Research US, Inc._Horsham
- Colorado
  - Aurora, Colorado, United States, 80045
    - University of Colorado Hospital
  - Colorado Springs, Colorado, United States, 80906
    - Optumcare Colorado Springs, LLC
  - Colorado Springs, Colorado, United States, 80906
    - Optumcare Colorado Springs
  - Golden, Colorado, United States, 80401
    - New West Physicians,Inc.
  - Monument, Colorado, United States, 80132
    - Optumcare Colorado Springs, LLC_Monument
- Connecticut
  - Bridgeport, Connecticut, United States, 06610
    - Bridgeport Hospital
  - New Haven, Connecticut, United States, 06510
    - Yale University School Of Medicine
  - Waterbury, Connecticut, United States, 06708
    - Chase Medical Research LLC
- Florida
  - Boca Raton, Florida, United States, 33434
    - Excel Med Ctr Clinical Trials
  - Bradenton, Florida, United States, 34205
    - Bradenton Research Center
  - Clearwater, Florida, United States, 33756
    - Clearwater Cardiovascular Consultants
  - Crystal River, Florida, United States, 34429
    - Nature Coast Clin Rsrch_Crystal River
  - Delray Beach, Florida, United States, 33445
    - Florida Premier Cardiology
  - Fleming Island, Florida, United States, 32003
    - Fleming Island Center for Clinical Research
  - Fleming Island, Florida, United States, 32003
    - Northeast Research Institute
  - Fort Lauderdale, Florida, United States, 33312
    - Integrative Research Assoc Inc
  - Hollywood, Florida, United States, 33024
    - Clinical Research of Hollywood_Hollywood
  - Jacksonville, Florida, United States, 32256
    - Clinical Neuroscience Solutions, Inc.
  - Jacksonville, Florida, United States, 32216
    - Jacksonville Ctr For Clin Res
  - Jacksonville, Florida, United States, 32216
    - Est Cst Inst for Rsrch,Jksnvil
  - Jacksonville, Florida, United States, 32258
    - Baptist Heart Specialists_Jacksonville
  - Jacksonville Beach, Florida, United States, 32250
    - Baptist Heart Specialists_Jacksonville Beach
  - Miami, Florida, United States, 33175
    - Reyes Clinical Research, Inc
  - Miami, Florida, United States, 33183
    - International Research Associates, LLC_Miami
  - Orlando, Florida, United States, 32804
    - AdventHealth Diab Inst
  - Oviedo, Florida, United States, 32765
    - Oviedo Medical Research, LLC
  - Saint Augustine, Florida, United States, 32086
    - East Coast Institute for Research LLC
  - Sarasota, Florida, United States, 34239
    - Intercoastal Medical Group
  - Wellington, Florida, United States, 33449
    - Cardio Partners Clin Res Inst
- Georgia
  - Alpharetta, Georgia, United States, 30022
    - Ellipsis Group
  - Johns Creek, Georgia, United States, 30024
    - NSC Research, Inc
  - Roswell, Georgia, United States, 30076
    - Endocrine Research Solutions
  - Statesboro, Georgia, United States, 30461
    - Family Health Care Center
  - Suwanee, Georgia, United States, 30024
    - Herman Clinical Research LLC
  - Tucker, Georgia, United States, 30084
    - Atlanta Heart Specialists, LLC
- Illinois
  - Arlington Heights, Illinois, United States, 60005
    - Northwest Heart Clinical Research, LLC
  - Chicago, Illinois, United States, 60616
    - Mercy Hospital and Medical Center
  - Chicago, Illinois, United States, 60607
    - Apex Medical Research Inc
  - Gillespie, Illinois, United States, 62033
    - Macoupin Research Group
  - Hazel Crest, Illinois, United States, 60429
    - Chicago Medical Research LLC
  - Oakbrook Terrace, Illinois, United States, 60181
    - Lemah Creek Clinical Research
  - Skokie, Illinois, United States, 60077
    - NorthShore Univ Hlth Sys
  - Skokie, Illinois, United States, 60077
    - Evanston Premier Hlthcr Res
  - Springfield, Illinois, United States, 62711
    - Central Illinois Diabetes and Clinical Research
- Indiana
  - Anderson, Indiana, United States, 46011
    - Community Clinical Research_Anderson
  - Avon, Indiana, United States, 46123
    - American Health Network of Indiana, LLC_Avon_0
  - Evansville, Indiana, United States, 47714
    - MediSphere Medical Research Center, LLC
  - Franklin, Indiana, United States, 46131
    - American Health Network of IN LLC_Franklin
  - Greenfield, Indiana, United States, 46140
    - American Health Network of Indiana, LLC_Greenfield
  - Michigan City, Indiana, United States, 46360
    - Franciscan Health Michigan City
  - Muncie, Indiana, United States, 47304
    - American Health Network of IN LLC
  - New Albany, Indiana, United States, 47150
    - American Health Network of Indiana, LLC
  - Valparaiso, Indiana, United States, 46383
    - Velocity Clinical_Valparaiso
- Iowa
  - Iowa City, Iowa, United States, 52242
    - University of Iowa Prev Inter Ctr
- Kansas
  - Kansas City, Kansas, United States, 66160
    - The University Of Kansas Medical Center - Cray Dia
  - Overland Park, Kansas, United States, 66211
    - Midwest Heart & Vasc Spec
  - Topeka, Kansas, United States, 66606
    - Cotton O'Neil Clin Research Ctr
- Kentucky
  - Louisville, Kentucky, United States, 40213
    - L-MARC Research Center
  - Louisville, Kentucky, United States, 40206
    - Robley Rex VA Medical Center
  - Louisville, Kentucky, United States, 40213
    - Norton Clinical Research Group
- Louisiana
  - Alexandria, Louisiana, United States, 71301
    - Cambridge Medical Trials
  - Hammond, Louisiana, United States, 70403
    - Louisiana Heart Center
  - Natchitoches, Louisiana, United States, 71457-5881
    - Barnum Medical Research, Inc.
  - Slidell, Louisiana, United States, 70458
    - Louisiana Heart Center_Slidell
- Maryland
  - Annapolis, Maryland, United States, 21401
    - Anne Arundel Medical Center
  - Baltimore, Maryland, United States, 21201
    - University of Maryland School of Medicine
  - Baltimore, Maryland, United States, 21229
    - Ascension Saint Agnes Heart Ca
  - Baltimore, Maryland, United States, 21239
    - MedStar Good Samaritan Hosp
  - Columbia, Maryland, United States, 21044
    - Johns Hopkins University
  - Elkridge, Maryland, United States, 21075-6437
    - Centennial Medical Group
  - Oxon Hill, Maryland, United States, 20745
    - MD Medical Research
  - Rockville, Maryland, United States, 20852
    - Endo And Metab Cons
- Massachusetts
  - Boston, Massachusetts, United States, 02115-5804
    - Brigham & Women's Hospital
- Michigan
  - Ann Arbor, Michigan, United States, 48109
    - Michigan Medicine
  - Canton, Michigan, United States, 48187
    - ClinSite LLC.
  - Detroit, Michigan, United States, 48202
    - Henry Ford Health System
  - Flint, Michigan, United States, 48504
    - Aa Mrc Llc
  - Ypsilanti, Michigan, United States, 48197
    - Trinity Health Michigan Heart
- Mississippi
  - Belzoni, Mississippi, United States, 39038
    - Belzoni Clinical Research
- Missouri
  - Saint Louis, Missouri, United States, 63128
    - Amicis Centers of Clinical Research
  - Saint Louis, Missouri, United States, 63136
    - St Louis Heart & Vascular, P.C.
- Montana
  - Butte, Montana, United States, 59701
    - Mercury Street Medical Group, PLLC_Butte
- Nebraska
  - Omaha, Nebraska, United States, 68198
    - University of NE Med Ctr
  - Omaha, Nebraska, United States, 68105
    - VA NEB - Western IA Health Stm
- Nevada
  - Henderson, Nevada, United States, 89052
    - Synexus Clinical Research US
  - Las Vegas, Nevada, United States, 89128
    - Palm Research Center Inc-Vegas
- New Hampshire
  - Nashua, New Hampshire, United States, 03060
    - Southern NH Diabetes and Endo_Nashua
- New Jersey
  - East Brunswick, New Jersey, United States, 08816
    - UniMed Center
  - Teaneck, New Jersey, United States, 07666
    - Holy Name Medical Center
- New York
  - Albany, New York, United States, 12203
    - Albany Medical College - Endo
  - Brooklyn, New York, United States, 11229
    - Dr. Alexander Perkelvald
  - Lake Success, New York, United States, 11042
    - Long Island Cardiovascular Consultants PC
  - New York, New York, United States, 10016
    - NYU School of Medicine
  - New York, New York, United States, 10016
    - NYU Grossman School of Med
  - New York, New York, United States, 10021
    - Comprehensive Weight Ctrl Prog
  - Saratoga Springs, New York, United States, 12866
    - Saratoga Clinical Research
  - West Seneca, New York, United States, 14224
    - Southgate Medical Group, LLP
  - Westfield, New York, United States, 14787
    - Great Lakes Medical Research
- North Carolina
  - Chapel Hill, North Carolina, United States, 27514
    - UNC Eastowne Clinical Trials Unit
  - Charlotte, North Carolina, United States, 28226
    - OnSite Clinical Solutions, LLC
  - Durham, North Carolina, United States, 27705
    - Duke University_Durham
  - Durham, North Carolina, United States, 27705
    - Durham VA Medical Center - Duke University
  - Garner, North Carolina, United States, 27529
    - WakeMed Garner Hlthplx
  - Greenville, North Carolina, United States, 27834
    - Physician's East Endocrinology
  - Lumberton, North Carolina, United States, 28358
    - Duke University - S.E Cardio
  - Morganton, North Carolina, United States, 28655
    - Burke Primary Care
  - Wilmington, North Carolina, United States, 28401
    - Accellacare
  - Winston-Salem, North Carolina, United States, 27103
    - PMG Research of Winston-Salem
- Ohio
  - Cincinnati, Ohio, United States, 45219
    - The Carl & Edyth Lindner Center
  - Cleveland, Ohio, United States, 44195
    - Cleveland Clinic_Cleveland
  - Dayton, Ohio, United States, 45439
    - Providence Health Partners Ctr
  - Maumee, Ohio, United States, 43537
    - Advanced Med Res Maumee
  - Wadsworth, Ohio, United States, 44281
    - New Venture Medical Research
- Oregon
  - Corvallis, Oregon, United States, 97330-3737
    - Corvallis Clinic PC Clinical Research Department
  - Portland, Oregon, United States, 97239
    - Oregon Health & Science Uni
- Pennsylvania
  - Danville, Pennsylvania, United States, 17822-2111
    - Geisinger Clinic
  - Doylestown, Pennsylvania, United States, 18901
    - Doylestown Hospital Pharmacy
  - Harleysville, Pennsylvania, United States, 19438
    - Harleysville Medical Associates
  - Johnstown, Pennsylvania, United States, 15905
    - Richard M Kastelic MD Assoc
  - Philadelphia, Pennsylvania, United States, 19104-4206
    - Hospital of the Univ PA
  - Philadelphia, Pennsylvania, United States, 19114
    - Tristar Clin Investigations, PC
  - Philadelphia, Pennsylvania, United States, 19144
    - Parkside Family Medicine
  - Pittsburgh, Pennsylvania, United States, 15243
    - Preferred Primary Care Physicians Inc.
- South Carolina
  - Anderson, South Carolina, United States, 29621
    - Internal Medicine Associates of Anderson
  - Anderson, South Carolina, United States, 29621
    - Synexus Clin Res US-Anderson
  - Charleston, South Carolina, United States, 29425
    - Medical Uni of SC Charleston
  - Greenville, South Carolina, United States, 29615
    - Palmetto Clinical Research
  - Mount Pleasant, South Carolina, United States, 29464
    - Accellacare US Inc._SC
- Tennessee
  - Bristol, Tennessee, United States, 37620-7352
    - Holston Medical Group Pc
  - Germantown, Tennessee, United States, 38138
    - The Stern Cardiovascular Group
  - Kingsport, Tennessee, United States, 37660
    - Holston Medical Group
  - Memphis, Tennessee, United States, 38119
    - Clinical Neuroscience Solutions
  - Nashville, Tennessee, United States, 37203
    - MidState Endocrine Associates
  - Nashville, Tennessee, United States, 37203
    - InvestiClin Research
  - Tullahoma, Tennessee, United States, 37388
    - Trinity Clinical Research LLC
- Texas
  - Amarillo, Texas, United States, 79106
    - Amarillo Med Spec LLP
  - Arlington, Texas, United States, 76012-4637
    - Arlington Family Res. Ctr Inc
  - Austin, Texas, United States, 78749
    - Texas Diab & Endo, P.A.
  - Bellaire, Texas, United States, 77401
    - UT Health University of Texas
  - Dallas, Texas, United States, 75390-9302
    - UT Southwestern Med Cntr
  - Dallas, Texas, United States, 75208
    - Thyroid, Endocrinology, and Diabetes, PA
  - Dallas, Texas, United States, 75231
    - Texas Health Physicians Group_Dallas
  - Houston, Texas, United States, 77070
    - Northwest Houston Cardiology, P.A.
  - Houston, Texas, United States, 77079
    - PlanIt Research, PLLC
  - Longview, Texas, United States, 75605
    - DCOL Ctr for Clin Res
  - Plano, Texas, United States, 75093
    - Research Institute of Dallas
  - San Antonio, Texas, United States, 78215
    - Sun Research Institute
  - San Antonio, Texas, United States, 78229
    - Audie L. Murphy VA Hospital, STVHCS
  - San Antonio, Texas, United States, 78209
    - Quality Research Inc
  - San Antonio, Texas, United States, 78230
    - VIP Trials
  - San Antonio, Texas, United States, 78220
    - San Antonio Prem Int Med
  - San Antonio, Texas, United States, 78228-6205
    - Physician PrimeCare Research Institute, PLLC dba
  - Sugar Land, Texas, United States, 77478
    - Simcare Medical Research, LLC
  - Sugar Land, Texas, United States, 77479
    - Houston Center for Clinical Research LLC
  - Tyler, Texas, United States, 75701
    - Christus Heart and Vascular Institute
  - Waco, Texas, United States, 76708
    - Hillcrest Family Health Center
- Utah
  - Bountiful, Utah, United States, 84010
    - Wade Family Medicine
  - West Valley City, Utah, United States, 84120
    - Kalo Clinical Research
- Vermont
  - South Burlington, Vermont, United States, 05403-7205
    - U. of Vermont Med Ctr Burlington
- Virginia
  - Alexandria, Virginia, United States, 23306
    - Inova Cardiology - Mt. Vernon
  - Danville, Virginia, United States, 24541
    - Cardiology Consultants of Danville Inc.
  - Fairfax, Virginia, United States, 22031
    - Inova Cardiology-Fairfax
  - Midlothian, Virginia, United States, 23114
    - Virginia Research Center
  - Norfolk, Virginia, United States, 23504
    - York Clinical Research LLC
  - Norfolk, Virginia, United States, 23510
    - Strelitz Diabetes Of Eastern V.
  - Richmond, Virginia, United States, 23219
    - Dominion Medical Associates
  - Richmond, Virginia, United States, 23226
    - Clinical Research Partners, LLC
  - Richmond, Virginia, United States, 23294
    - National Clin Res Inc.
  - Salem, Virginia, United States, 24153-6404
    - VA Medical Center_Salem
  - Virginia Beach, Virginia, United States, 23454
    - Bayview Physician Services
  - Virginia Beach, Virginia, United States, 23454
    - Sentara Medical Group_Norfolk
  - Winchester, Virginia, United States, 22601
    - Amherst Family Practice P.C.
  - Winchester, Virginia, United States, 22601-3834
    - Selma Medical Associates
- Washington
  - Olympia, Washington, United States, 98502
    - Capital Clin Res Ctr,LLC
  - Wenatchee, Washington, United States, 98801-2028
    - Wenatchee Valley Hospital and Clinics
- Wisconsin
  - Green Bay, Wisconsin, United States, 54303
    - St. Vincent Hosp-Prevea Health
  - Kenosha, Wisconsin, United States, 53144
    - Clinical Inv Spec, Inc.Kenosha
  - Wausau, Wisconsin, United States, 54401
    - Aspirus Research Institute

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

45 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Description

Inclusion Criteria:

Informed consent obtained before any trial-related activities. Trial-related activities are any procedures that are carried out as part of the trial, including activities to determine suitability for the trial
Male or female, age greater than or equal to 45 years at the time of signing informed consent
Body mass index (BMI) greater than or equal to 27 kg/m^2
Have established cardiovascular (CV) disease as evidenced by at least one of the following: prior myocardial infarction; prior stroke (ischemic or haemorrhagic stroke); or symptomatic peripheral arterial disease (PAD), as evidenced by intermittent claudication with ankle-brachial index (ABI) less than 0.85 (at rest), or peripheral arterial revascularization procedure, or amputation due to atherosclerotic disease

Exclusion Criteria:

Cardiovascular-related:

Any of the following: myocardial infarction, stroke, hospitalisation for unstable angina pectoris or transient ischaemic attack within the past 60 days prior to the day of screening
Planned coronary, carotid or peripheral artery revascularisation known on the day of screening
Presently classified as being in New York Heart Association (NYHA) Class IV heart failure

Glycaemia-related:

HbA1c greater than or equal to 48 mmol/mol (6.5 %) as measured by the central laboratory at screening
History of type 1 or type 2 diabetes (history of gestational diabetes is allowed)
Treatment with glucose-lowering agents within 90 days before screening
Treatment with any glucagon-like-peptide-1 receptor agonist (GLP-1 RA) within 90 days before screening

General safety:

History or presence of chronic pancreatitis
Presence of acute pancreatitis within the past 180 days prior to the day of screening
Personal or first degree relative(s) history of multiple endocrine neoplasia type 2 or medullary thyroid carcinoma
End stage renal disease or chronic or intermittent haemodialysis or peritoneal dialysis
Presence or history of malignant neoplasms within the past 5 years prior to the day of screening. Basal and squamous cell skin cancer and any carcinoma in-situ are allowed
Severe psychiatric disorder which in the investigator's opinion could compromise compliance with the protocol
Known or suspected hypersensitivity to trial products or related products
Previous participation in this trial. Participation is defined as randomisation
Receipt of any investigational medicinal product within 30 days before screening
Female who is pregnant, breast-feeding or intends to become pregnant or is of child-bearing potential and not using a highly effective contraceptive method
Any disorder, unwillingness or inability, which in the investigator's opinion, might jeopardise the participant's safety or compliance with the protocol

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Quadruple

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Semaglutide Participants will receive semaglutide as an adjunct to standard-of-care. Estimated trial duration for an individual subject is from 31 to 59 months.	Drug: Semaglutide Semaglutide will be injected into a skin fold, in the stomach, thigh or upper arm once a week at the same day of the week (to the extent possible) throughout the trial. Subjects will start semaglutide treatment at 0.24 mg; dose will gradually be increased every 4 weeks up to 2.4 mg.
Placebo Comparator: Placebo (semaglutide) Participants will receive placebo (semaglutide) as an adjunct to standard-of-care. Estimated trial duration for an individual subject is from 31 to 59 months.	Drug: Placebo (semaglutide) Placebo will be injected into a skin fold, in the stomach, thigh or upper arm once a week at the same day of the week (to the extent possible) throughout the trial. Participants will receive placebo at an equivalent dose to semaglutide.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time to first occurrence of a composite endpoint consisting of: cardiovascular (CV) death, non-fatal myocardial infarction, or non-fatal stroke Time Frame: 0-59 months	Measured in months	0-59 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time to CV death Time Frame: 0-59 months	Measured in months	0-59 months
Time to all-cause death Time Frame: 0-59 months	Measured in months	0-59 months
Time to first occurrence of an expanded composite CV endpoint consisting of: CV death, non-fatal myocardial infarction, non-fatal stroke, coronary revascularisation or unstable angina requiring hospitalisation Time Frame: 0-59 months	Measured in months	0-59 months
Time to first occurrence of a composite heart failure endpoint consisting of: heart failure hospitalisation, urgent heartfailure visit or CV death Time Frame: 0-59 months	Measured in months	0-59 months
Time to first occurrence of a composite endpoint consisting of: all-cause death, non-fatal myocardial infarction, or non-fatal stroke Time Frame: 0-59 months	Measured in months	0-59 months
Time to first occurrence of non-fatal myocardial infarction Time Frame: 0-59 months	Measured in months	0-59 months
Time to first occurrence of non-fatal stroke Time Frame: 0-59 months	Measured in months	0-59 months
Time to first occurrence of coronary revascularisation Time Frame: 0-59 months	Measured in months	0-59 months
Time to first occurrence of unstable angina requiring hospitalisation Time Frame: 0-59 months	Measured in months	0-59 months
Time to first occurrence of heart failure hospitalisation or urgent heart failure visit Time Frame: 0-59 months	Measured in months	0-59 months
Time to first occurrence of HbA1c greater than or equal to 48 mmol/mol (6.5%) Time Frame: 0-59 months	Measured in months	0-59 months
Time to first occurrence of a 5-component composite nephropathy endpoint Time Frame: 0-59 months	Measured in months. A 5-component composite nephropathy endpoint consists of: onset of persistent macroalbuminuria (UACR above 300 mg/g), persistent 50% reduction in estimated Glomerular Filtration Rate (eGFR) compared with baseline (randomisation), onset of persistent eGFR less than 15 ml/min/1.73m^2, initiation of chronic renal replacement therapy (dialysis or transplantation) or renal death.	0-59 months
Time to HbA1c greater than or equal to 39 mmol/mol (5.7%) for subjects with a screening HbA1c less than 39 mmol/mol (5.7%) Time Frame: 0-59 months	Measured in months	0-59 months
Subjects with HbA1c less than 39 mmol/mol (5.7%) at each visit where HbA1c is assessed for subjects with a screening HbA1c greater than or equal to 39 mmol/mol (5.7%) Time Frame: 0-59 months	Proportion of subjects	0-59 months
Change in systolic blood pressure Time Frame: Week 0, year 2	Measured in mm Hg	Week 0, year 2
Change in diastolic blood pressure Time Frame: Week 0, year 2	Measured in mm Hg	Week 0, year 2
Change in pulse Time Frame: Week 0, year 2	Measured in beats per minute	Week 0, year 2
Change in High sensitivity C-Reactive Protein (hsCRP) Time Frame: Week 0, year 2	Measured in mg/dL	Week 0, year 2
Change in total cholesterol Time Frame: Week 0, year 2	Measured in mg/dL	Week 0, year 2
Change in high density lipoprotein (HDL) cholesterol Time Frame: Week 0, year 2	Measured in mg/dL	Week 0, year 2
Change in low density lipoprotein (LDL) cholesterol Time Frame: Week 0, year 2	Measured in mg/dL	Week 0, year 2
Change in triglycerides Time Frame: Week 0, year 2	Measured in mg/dL	Week 0, year 2
Change in body weight Time Frame: Week 0, year 2	Measured in %	Week 0, year 2
Change in waist circumference Time Frame: Week 0, year 2	Measured in cm	Week 0, year 2
Change in EuroQol five dimensions five level (EQ-5D-5L) questionnaire Time Frame: Week 0, year 2	The EQ-5D-5L questionnaire will be used to estimate the impact on subjects' health-related quality of life and provides a description of subjects' problems by dimensions (descriptive system), a score for overall self-rated health (visual analogue scale [VAS]) as well as an index score (EQ-5D-5L index). EQ-5D index score range: 0 to 1 and EQ-5D-VAS: range 0 to 100. A higher score indicates better self reported health status.	Week 0, year 2
Change in total score weight related sign and symptom measure Time Frame: Week 0, year 2	The weight related sign and symptom measure assesses the presence and bother associated with weight-related symptoms using a self-rated VAS. It is a tool to assess the multifaceted aspects of obesity on symptom experience in subjects with overweight or obesity.	Week 0, year 2
Change in haemoglobin A1c (HbA1c) Time Frame: Screening (up to 3 weeks before randomisation at week 0), week 104	Measured in %	Screening (up to 3 weeks before randomisation at week 0), week 104
Change in HbA1c Time Frame: Screening (up to 3 weeks before randomisation at week 0), week 104	Measured in mmol/mol	Screening (up to 3 weeks before randomisation at week 0), week 104

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Novo Nordisk A/S

Investigators

Study Director: Clinical Transparency (dept.2834), Novo Nordisk A/S

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 24, 2018

Primary Completion (Actual)

June 21, 2023

Study Completion (Actual)

June 29, 2023

Study Registration Dates

First Submitted

June 21, 2018

First Submitted That Met QC Criteria

June 21, 2018

First Posted (Actual)

July 2, 2018

Study Record Updates

Last Update Posted (Actual)

April 2, 2024

Last Update Submitted That Met QC Criteria

March 31, 2024

Last Verified

March 1, 2024

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

EX9536-4388
2017-003380-35 (Registry Identifier: European Medicines Agency (EudraCT))
U1111-1200-5564 (Other Identifier: World Health Organization (WHO))

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

According to the Novo Nordisk disclosure commitment on novonordisk-trials.com

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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Study Overview

Status

Conditions

Intervention / Treatment

Study Type

Enrollment (Actual)

Phase

Contacts and Locations

Study Contact

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Secondary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Collaborators and Investigators

Sponsor

Investigators

Publications and helpful links

General Publications

Study record dates

Study Major Dates

Study Start (Actual)

Primary Completion (Actual)

Study Completion (Actual)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Actual)

Study Record Updates

Last Update Posted (Actual)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

IPD Plan Description

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product

Clinical Trials on Obesity

Clinical Trials on Semaglutide

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