Oocyte Vitrification Aided With Latrunculin A

July 14, 2019 updated by: Muhammad Fawzy, Ibn Sina Hospital

Latrunculin A for Oocyte Vitrification

Using cytoskeleton Stabilizer the Latrunculin A would improve the outcome of oocyte vitrification

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

400

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
      • Assiut, Egypt
        • Banon Assiut
      • Qena, Egypt, 123456
        • Qena Fertility Center
      • Sohag, Egypt, 12345
        • IbnSina IVF Center, IbnSina Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 42 years (Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

Female

Description

Inclusion Criteria:

  • indication for oocyte cryopreservation

Exclusion Criteria:

-

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Triple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Latrunculin A supplemented vitrification medium
Other: Latrunculin A supplemented vitrification medium
Vitrification of human oocyte in medium supplemented with Latrunculin A
No Intervention: Vitrification medium with no supplementation

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
survival after thawing
Time Frame: 6 days after thawing
6 days after thawing

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
fertilization rate
Time Frame: 6 days of culture
6 days of culture
Rates of blastocyst formation and quality
Time Frame: 6 days of culture
Number of formed blastocyst and high-quality blastocysts per fertilized oocytes
6 days of culture
embryo utilization rate
Time Frame: 6 days of culture
Number of utilized embryos per fertilized oocytes
6 days of culture
clinical pregnancy rate
Time Frame: three months
Number of pregnant women with fetal pulsation per recruited cycles
three months
ongoing pregnancy rate
Time Frame: 12 months
12 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Ibn Sina Hospital

Collaborators

Banoon IVF Center

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

September 25, 2018

Primary Completion (Actual)

July 1, 2019

Study Completion (Actual)

July 15, 2019

Study Registration Dates

First Submitted

September 17, 2018

First Submitted That Met QC Criteria

September 18, 2018

First Posted (Actual)

September 19, 2018

Study Record Updates

Last Update Posted (Actual)

July 16, 2019

Last Update Submitted That Met QC Criteria

July 14, 2019

Last Verified

July 1, 2019

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • IbnSina-Oocyte-LA

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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