Protein Ingestion and Skeletal Muscle Atrophy

September 25, 2020 updated by: University of Exeter

Understanding the Role of Protein Ingestion on Skeletal Muscle Atrophy During an Acute Period of Disuse

The effect of different protein intakes on skeletal muscle atrophy during short term unilateral leg immobilisation.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

33

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United Kingdom
    • Devon
      • Exeter, Devon, United Kingdom, EX1 2LU
        • Sport and Health Science

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 35 years (ADULT)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

Male

Description

Inclusion Criteria:

  • BMI >18 and <28 no prescription medications or current illness.

Exclusion Criteria:

  • BMI <18 and >28 current prescription medication no history of leg injury.
  • Smoker
  • Medical conditions including (cardiovascular disease ((e.g. hypertension)), metabolic disease ((e.g. type 2 diabetes)), any personal or family history of deep vein thrombosis.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: BASIC_SCIENCE
  • Allocation: RANDOMIZED
  • Interventional Model: PARALLEL
  • Masking: SINGLE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: High protein
Other: Lower limb immobilisation (leg brace) with varying levels of protein intake
Single leg immobilisation via leg brace and crutches, the groups have different amounts of protein intake
Experimental: Low protein
Other: Lower limb immobilisation (leg brace) with varying levels of protein intake
Single leg immobilisation via leg brace and crutches, the groups have different amounts of protein intake
Experimental: Minimum protein
Other: Lower limb immobilisation (leg brace) with varying levels of protein intake
Single leg immobilisation via leg brace and crutches, the groups have different amounts of protein intake

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Muscle size
Time Frame: 3 days
3 days

Secondary Outcome Measures

Outcome Measure
Time Frame
Muscle strength
Time Frame: 3 days
3 days

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Exeter

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 31, 2017

Primary Completion (Actual)

December 31, 2019

Study Completion (Actual)

December 31, 2019

Study Registration Dates

First Submitted

January 7, 2019

First Submitted That Met QC Criteria

January 7, 2019

First Posted (Actual)

January 9, 2019

Study Record Updates

Last Update Posted (Actual)

September 28, 2020

Last Update Submitted That Met QC Criteria

September 25, 2020

Last Verified

September 1, 2020

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 6500619582

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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