A Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes (SURPASS-CVOT)

June 11, 2026 updated by: Eli Lilly and Company

The Effect of Tirzepatide Versus Dulaglutide on Major Adverse Cardiovascular Events in Patients With Type 2 Diabetes (SURPASS-CVOT)

The purpose of the trial is to assess the efficacy and safety of tirzepatide to dulaglutide in participants with type 2 diabetes and increased cardiovascular risk.

Study Overview

Status

Completed

Conditions

Type 2 Diabetes Mellitus

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

13299

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Argentina
- - Buenos Aires, Argentina, 1407
    - CEMEDIC
  - Buenos Aires, Argentina, C1419AHN
    - Asociacion de Beneficencia Hospital Sirio Libanes
  - Buenos Aires, Argentina, 1430
    - Glenny Corp
  - Buenos Aires, Argentina, C1061
    - CIPREC
  - Corrientes, Argentina, 3400
    - Centro Universitario de Investigación en Farmacologia Clínic
  - Corrientes, Argentina, 3400
    - Instituto de Cardiología "Juana F. Cabral"
  - Córdoba, Argentina, X5000AVE
    - CIDIM-Centro Integral de Diagnostico por Imagenes Marchegiani
  - Córdoba, Argentina, X5000JJS
    - Centro Diabetológico Dr. Waitman
  - Salta, Argentina, 4400
    - Instituto Médico Alas
  - Santiago del Estero, Argentina, 4200
    - Sanatorio Norte
- Buenos Aires
  - Bahía Blanca, Buenos Aires, Argentina, 8000
    - Instituto de Investigaciones Clínicas Bahia Blanca
  - CABA, Buenos Aires, Argentina, C1015
    - Organizacion Medica de Investigacion
  - CABA, Buenos Aires, Argentina, C1060ABN
    - CEDIC
  - Capital Federal, Buenos Aires, Argentina, 1023
    - Stat Research S.A.
  - Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, C1056ABI
    - Centro de Investigaciones Metabólicas (CINME)
  - Mar del Plata, Buenos Aires, Argentina, 7600
    - Instituto de Investigaciones Clinicas Mar Del Plata
  - Ramos Mejía, Buenos Aires, Argentina, 1704
    - DIM Clinica Privada
  - San Nicolás de los Arroyos, Buenos Aires, Argentina, 2900
    - Go Centro Medico San Nicolás
  - Zárate, Buenos Aires, Argentina, B2800DGH
    - Instituto de Investigaciones Clínicas Zarate
- Buenos Aires F.D.
  - Buenos Aires, Buenos Aires F.D., Argentina, C1120AAC
    - Centro Médico Viamonte
  - Buenos Aires, Buenos Aires F.D., Argentina, C1425AGC
    - Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
  - Buenos Aires, Buenos Aires F.D., Argentina, C1128AAF
    - Mautalen Salud e investigación
  - C.a.b.a., Buenos Aires F.D., Argentina, C1205AAO
    - CEMEDIAB
- Córdoba Province
  - Capital, Córdoba Province, Argentina, X5008HHW
    - Centro Médico Privado CEMAIC
  - Córdoba, Córdoba Province, Argentina, 5006
    - Centro Médico Privado San Vicente Diabetes
- Santa Fe Province
  - Rosario, Santa Fe Province, Argentina, 2000
    - Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica
  - Rosario, Santa Fe Province, Argentina, 2000
    - Instituto Médico Catamarca IMEC
  - Rosario, Santa Fe Province, Argentina, S2000CVD
    - Instituto de Investigaciones Clinicas Rosario
- Tucumán Province
  - SAN M. de Tucuman, Tucumán Province, Argentina, T4000AXL
    - Centro de Investigaciones Medicas Tucuman
  - San Miguel de Tucumán, Tucumán Province, Argentina, 4000
    - Clinica Mayo de Urgencias Medicas Cruz Blanca S.R.L
  - San Miguel de Tucumán, Tucumán Province, Argentina, 4000
    - Investigaciones Clinicas Tucuman
Australia
- New South Wales
  - Merewether, New South Wales, Australia, 2291
    - The AIM Centre / Hunter Diabetes Centre
  - Penrith, New South Wales, Australia, 2747
    - Nepean Hospital
  - Sydney, New South Wales, Australia, 2006
    - University of Sydney - Charles Perkins Centre
  - Wollongong, New South Wales, Australia, 2500
    - Illawarra Shoalhaven Local Health District
- Queensland
  - Brisbane, Queensland, Australia, 4029
    - Royal Brisbane and Women's Hospital
  - Brisbane, Queensland, Australia, 4064
    - Core Research Group
  - Brisbane, Queensland, Australia, 4101
    - Mater Misericordiae Limited
  - Southport, Queensland, Australia, 4215
    - Gold Coast University Hospital
  - Townsville, Queensland, Australia, 4814
    - The Townsville Hospital
- South Australia
  - Adelaide, South Australia, Australia, 5000
    - Royal Adelaide Hospital
  - Adelaide, South Australia, Australia, 5000
    - Nightingale Research
  - Oaklands Park, South Australia, Australia, 5046
    - Southern Adelaide Diabetes & Endocrine Services
- Tasmania
  - Launceston, Tasmania, Australia, 7250
    - Launceston General Hospital
- Victoria
  - Box Hill, Victoria, Australia, 3128
    - Box Hill Hospital
  - Clayton, Victoria, Australia, 3168
    - Victorian Heart Hospital
  - Geelong, Victoria, Australia, 3220
    - Barwon Health
  - Heidelberg West, Victoria, Australia, 3084
    - Austin Health - Repatriation Hospital
- Western Australia
  - Fremantle, Western Australia, Australia, 6160
    - School of Medicine, Fremantle Hospital
  - Joondalup, Western Australia, Australia, 6027
    - Advara HeartCare Joondalup
  - Murdoch, Western Australia, Australia, 6150
    - GenesisCare - Murdoch - Murdoch Drive
Austria
- - Salzburg, Austria, 5020
    - Uniklinikum Salzburg
  - Vienna, Austria, 1030
    - Klinik Landstraße
  - Vienna, Austria, 1060
    - Zentrum für klinische Studien Dr Hanusch Gmbh
  - Vienna, Austria, 1090
    - Universitaetsklinikum Allgemeines Krankenhaus Wien
  - Vienna, Austria, 1130
    - Klinik Hietzing
- Styria
  - Graz, Styria, Austria, 8036
    - Medizinische Universität Graz
Belgium
- - Liège, Belgium, 4000
    - Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman
- Antwerpen
  - Bonheiden, Antwerpen, Belgium, 2820
    - Imelda General Hospital
  - Brasschaat, Antwerpen, Belgium, 2930
    - Algemeen Ziekenhuis klina
  - Edegem, Antwerpen, Belgium, 2650
    - Antwerp University Hospital
- Bruxelles-Capitale, Région de
  - Brussels, Bruxelles-Capitale, Région de, Belgium, 1090
    - UZ Brussel
  - Brussels, Bruxelles-Capitale, Région de, Belgium, 1070
    - Universite Libre de Bruxelles - Hopital ERASME
- Flanders
  - Merksem, Flanders, Belgium, 2170
    - ZAS Jan Palfijn
- Oost-Vlaanderen
  - Aalst, Oost-Vlaanderen, Belgium, 9300
    - AZORG Campus Aalst-Moorselbaan
  - Sint-Niklaas, Oost-Vlaanderen, Belgium, B-9100
    - AZ Nikolaas
- Vlaams-Brabant
  - Leuven, Vlaams-Brabant, Belgium, 3000
    - UZ Leuven
- West-Vlaanderen
  - Bruges, West-Vlaanderen, Belgium, 8000
    - AZ Sint-Jan Brugge-Oostende AV
  - Kortrijk, West-Vlaanderen, Belgium, 8500
    - AZ Groeninge Campus Kennedylaan
  - Ostend, West-Vlaanderen, Belgium, 8400
    - Az Damiaan vzw
  - Roeselare, West-Vlaanderen, Belgium, 8800
    - AZ Delta VZW
Brazil
- - Rio de Janeiro, Brazil, 22241-180
    - IBPClin - Instituto Brasil de Pesquisa Clínica
  - São Paulo, Brazil, 01228-000
    - CPQuali Pesquisa Clinica
  - São Paulo, Brazil, 05403-000
    - Hospital das Clinicas FMUSP
  - São Paulo, Brazil, 04266-010
    - Hospital das Clinicas FMUSP
- Ceará
  - Fortaleza, Ceará, Brazil, 60430-350
    - Private Practice - Dr.Miguel N. Hissa
- Espírito Santo
  - Vitória, Espírito Santo, Brazil, 29055450
    - CEDOES
- Paraná
  - Curitiba, Paraná, Brazil, 80045170
    - Quanta Diagnóstico e Terapia
- Rio Grande do Sul
  - Porto Alegre, Rio Grande do Sul, Brazil, 90430-001
    - Nucleo de Pesquisa Clinica do Rio Grande do Sul
- São Paulo
  - Campinas, São Paulo, Brazil, 13060-080
    - Instituto de Pesquisa Clínica de Campinas
  - Campinas, São Paulo, Brazil, 13092-133
    - Loema Instituto de Pesquisa Clinica
  - Jaú, São Paulo, Brazil, 17201130
    - CECIP - Centro de Estudos do Interior Paulista
  - Santo André, São Paulo, Brazil, 09060-870
    - Faculdade de Medicina do ABC
  - São José dos Campos, São Paulo, Brazil, 12243-280
    - ISPEM - Instituto São José dos Campos em Pesquisas Médicas
  - São Paulo, São Paulo, Brazil, 01223-001
    - Instituto de Pesquisa Clinica
  - São Paulo, São Paulo, Brazil, 01228-200
    - CPCLIN
Canada
- - Québec, Canada, G1V 4T3
    - Diex Recherche Québec
- Alberta
  - Calgary, Alberta, Canada, T2H 2G4
    - LMC Diabetes & Endocrinology
- British Columbia
  - Vancouver, British Columbia, Canada, V5Y 3W2
    - BC Diabetes Office
  - Victoria, British Columbia, Canada, V8V 4A1
    - Dr. M.B. Jones Inc.
- Manitoba
  - Winnipeg, Manitoba, Canada, MB R3C 0N2
    - Winnipeg Clinic
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 1V7
    - NSHA-QEII Health Sciences Centre-Dickson Bldg
- Ontario
  - Barrie, Ontario, Canada, L4N 7L3
    - LMC Clinical Research Inc. (Barrie)
  - Brampton, Ontario, Canada, L6T 0G1
    - Aggarwal and Associates Limited
  - Brampton, Ontario, Canada, L6S 0C9
    - LMC Diabetes & Endocrinology
  - Cambridge, Ontario, Canada, N1R 6V6
    - Cambridge Cardiac Care Centre
  - Concord, Ontario, Canada, L4K 4M2
    - LMC Clinical Research Inc. (Thornhill)
  - Greater Sudbury, Ontario, Canada, P3C 1S8
    - Janik Research Corporation
  - London, Ontario, Canada, N5W 6A2
    - Milestone Research Inc.
  - London, Ontario, Canada, N6A 4V2
    - St. Joseph's Health Care
  - North York, Ontario, Canada, M6B 3H7
    - North York Diagnostic and Cardiac Centre
  - Oakville, Ontario, Canada, L6M 1M1
    - LMC Clinical Research Inc. (Oakville)
  - Oshawa, Ontario, Canada, L1G 2K1
    - Private Practice - Dr. James Cha
  - Ottawa, Ontario, Canada, K2J 0V2
    - LMC Manna Research
  - Peterborough, Ontario, Canada, K9J 0B2
    - Kawartha Cardiology Clinical Trials
  - Sarnia, Ontario, Canada, N7T 4X3
    - Bluewater Clinical Research Group Inc.
  - Smiths Falls, Ontario, Canada, K7A 4W8
    - Diabetes Clinic
  - Toronto, Ontario, Canada, M4G 3E8
    - LMC Clinical Research Inc. (Bayview)
  - Toronto, Ontario, Canada, M9V 4B4
    - Dr. Anil K. Gupta Medicine Professional Corporation
  - Toronto, Ontario, Canada, M6G 1M2
    - Diabetes Heart Research Centre
  - Toronto, Ontario, Canada, M3J 0K2
    - Canadian Phase Onward
- Quebec
  - Greenfield Park, Quebec, Canada, J4V 2G8
    - Viacar Recherche Clinique
  - Laval, Quebec, Canada, H7T 2P5
    - Centre de Recherche Clinique de Laval
  - Lévis, Quebec, Canada, G6W 0M5
    - Manna Research
  - Montreal, Quebec, Canada, H1T 3Y7
    - Clinique Sante Cardio MC
China
- Beijing Municipality
  - Beijing, Beijing Municipality, China, 100034
    - Peking University First Hospital
  - Beijing, Beijing Municipality, China, 100029
    - Beijing AnZhen Hospital, Capital Medical University
  - Beijing, Beijing Municipality, China, 100034
    - Peking University People's Hospital
  - Beijing, Beijing Municipality, China, 100050
    - Beijing Friendship Hospital
- Gansu
  - Lanzhou, Gansu, China, 730000
    - The First Hospital of Lanzhou University
  - Lanzhou, Gansu, China, 730030
    - Lanzhou University Second Hospital
- Guangdong
  - Guangzhou, Guangdong, China
    - The First Affiliated Hospital, Sun Yat-sen University
- Heilongjiang
  - Harbin, Heilongjiang, China, 150001
    - The Fourth Affiliated Hospital of Harbin Medical University
- Hunan
  - Changsha, Hunan, China, 410005
    - Hunan Provincial People's Hospital
- Jiangsu
  - Huai'an, Jiangsu, China, 223300
    - First Huai'an Hospital Affiliated to Nanjing Medical University
  - Nanjing, Jiangsu, China, 210009
    - Zhongda Hospital Southeast University
  - Nanjing, Jiangsu, China, 210011
    - The Second Affiliated Hospital of Nanjing Medical University
  - Nanjing, Jiangsu, China, 210000
    - Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing university Medical School
  - Nanjing, Jiangsu, China, 210012
    - Nanjing First Hospital
  - Zhenjiang, Jiangsu, China, 212000
    - Affiliated Hospital of Jiangsu University
- Jiangxi
  - Nanchang, Jiangxi, China, 330006
    - The First Affiliated Hospital of Nanchang University
  - Pingxiang, Jiangxi, China, 337055
    - Jiangxi Pingxiang People's Hospital
- Jilin
  - Changchun, Jilin, China, 130033
    - China-Japan Union Hospital
- Liaoning
  - Shenyang, Liaoning, China, 110016
    - The People's Hospital of Liaoning Province
- Ningxia
  - Yinchuan, Ningxia, China, 750004
    - General Hospital of Ningxia Medical University
- Shaanxi
  - Xi'an, Shaanxi, China, 710061
    - The first Affiliated Hospital of Xi'an Jiaotong University
- Shandong
  - Jinan, Shandong, China, 250013
    - Jinan Central Hospital
- Tianjin Municipality
  - Tianjin, Tianjin Municipality, China, 300052
    - Tianjin Medical University General Hospital
Czechia
- - Prague, Czechia, 12808
    - Vseobecna Fakultni Nemocnice V Praze
  - Prague, Czechia, 14900
    - Milan Kvapil s.r.o., Diabetologicka ambulance
  - Prague, Czechia, 140 00
    - MUDr. Michala Pelikanova s.r.o.
- Moravian-Silesian Region
  - Krnov, Moravian-Silesian Region, Czechia, 79401
    - MUDr. Tomas Edelsberger
- Náchod
  - Náchod, Náchod, Czechia, 547 01
    - Interni a diabetologicka ordinace, s.r.o.
- Praha 1
  - Prague, Praha 1, Czechia, 11000
    - Diabet2 s.r.o., diabetologicka a interni ambulance
- Praha 8
  - Prague, Praha 8, Czechia, 18100
    - ResTrial s.r.o.
- Praha 9
  - Praha 9 - Klanovice, Praha 9, Czechia, 190 14
    - MUDr. Barbora Diepoltova
- Praha-východ
  - Brandýs nad Labem, Praha-východ, Czechia, 25001
    - Diacentrum Brandys n.L. s.r.o.
- South Bohemian Region
  - České Budějovice, South Bohemian Region, Czechia, 37011
    - MUDr. Alena Vachova
France
- - Paris, France, 75018
    - Hôpital Bichat - Claude-Bernard
  - Paris, France, 75010
    - Assistance Publique Hôpitaux de Paris - Groupe Hospitalier 10e - Hôpital Lariboisière
- Aquitaine
  - Pessac, Aquitaine, France, 33600
    - CHU Bordeaux Haut-Leveque
- Auvergne-Rhône-Alpes
  - Vénissieux, Auvergne-Rhône-Alpes, France, 69200
    - Groupe Hospitalier Mutualiste Les Portes du Sud
- Bourgogne-Franche-Comté
  - Le Creusot, Bourgogne-Franche-Comté, France, 71200
    - Hôtel-Dieu du Creusot - site Harfleur
- Côte-d'Or
  - Dijon, Côte-d'Or, France, 21000
    - Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand
- Haute-Garonne
  - Toulouse, Haute-Garonne, France, 31059
    - CHU Rangueil
- Loire-Atlantique
  - Saint-Herblain, Loire-Atlantique, France, 44800
    - Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes
- Lorraine
  - Vandœuvre-lès-Nancy, Lorraine, France, 54511
    - Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois
- Île-de-France Region
  - Corbeil-Essonnes, Île-de-France Region, France, 91106
    - Centre Hospitalier Sud Francilien
  - Paris, Île-de-France Region, France, 75014
    - Groupe Hospitalier Paris Saint Joseph
Germany
- - Berlin, Germany, 10437
    - Institut für klinische Forschung und Entwicklung
  - Berlin, Germany, 13187
    - Diabetespraxis Prenzlauer Alle
  - Hamburg, Germany, 22607
    - Diabeteszentrum Hamburg West
  - Hamburg, Germany, 21073
    - Diabetologische Schwerpunktpraxis Harburg
  - Hamburg, Germany, 21109
    - Diabetes Zentrum Wilhelmsburg
  - Heidelberg, Germany, 69115
    - St. Josefskrankenhaus Heidelberg
- Baden-Wurttemberg
  - Deggingen, Baden-Wurttemberg, Germany, 73326
    - Gemeinschaftspraxis Dres. Jung
  - Stuttgart, Baden-Wurttemberg, Germany, 70199
    - Marienhospital Stuttgart
  - Villingen-Schwenningen, Baden-Wurttemberg, Germany, 78048
    - Gemeinschaftspraxis Prof. Dr. med. Stephan Jacob, Dr. med. Frohmut Jacob
  - Wangen, Baden-Wurttemberg, Germany, 88239
    - Praxis Sauter & Sauter & Vorbach
- Bavaria
  - Bamberg, Bavaria, Germany, 96049
    - CIMS Studienzentrum Bamberg
  - Lichtenfels, Bavaria, Germany, 96215
    - Private Practice - Dr. Ilka Simon-Wagner
  - München, Bavaria, Germany, 80809
    - CDG Studienambulanz Hartard
- Brandenburg
  - Elsterwerda, Brandenburg, Germany, 04910
    - ZKS Suedbrandenburg
  - Falkensee, Brandenburg, Germany, 14612
    - ZKS Dr. Lüdemann
- Hesse
  - Frankfurt am Main, Hesse, Germany, 60596
    - ClinPhenomics GmbH & Co KG
  - Fulda, Hesse, Germany, 36037
    - MVZ im Altstadt-Carree Fulda GmbH
  - Gelnhausen, Hesse, Germany, 63571
    - Diabetes Zentrum Dr. Tews
  - Pohlheim, Hesse, Germany, 35415
    - Diabetologische Schwerpunktpraxis Marck Linn Pickel
- Lower Saxony
  - Lüneburg, Lower Saxony, Germany, 21339
    - Praxis Oedeme
  - Rehlingen, Lower Saxony, Germany, 66780
    - Praxis Dr. Veronika Wenzl-Bauer
- North Rhine-Westphalia
  - Bad Oeynhausen, North Rhine-Westphalia, Germany, 32545
    - Herz - und Diabeteszentrum Nordrhein - Westfalen, Bad Oeynhausen
  - Bochum, North Rhine-Westphalia, Germany, 44869
    - Diabetes- und Stoffwechselpraxis Bochum
  - Dortmund, North Rhine-Westphalia, Germany, 44137
    - Private Practice - Dr. Claus Busch, Dr. Christian Busch & Dr. Christopher Cramer
  - Essen, North Rhine-Westphalia, Germany, 45355
    - Medizentrum Essen Borbeck
  - Essen, North Rhine-Westphalia, Germany, 45136
    - InnoDiab Forschung GmbH
  - Essen, North Rhine-Westphalia, Germany, 45355
    - Private Practice - Dr. Bernd Becker
  - Münster, North Rhine-Westphalia, Germany, 48145
    - Institut für Diabetesforschung GmbH Münster
- Rhineland-Palatinate
  - Ludwigshafen am Rhein, Rhineland-Palatinate, Germany, 67059
    - Diabetologikum Ludwigshafen/Die Praxis am Ludwigsplatz
  - Speyer, Rhineland-Palatinate, Germany, 67346
    - Diabetologische Schwerpunktpraxis Diabetologikum Speyer
- Saarland
  - Friedrichsthal, Saarland, Germany, 66299
    - Practice Dr.med. Denger and Dr.med. Pfitzner
  - Saint Ingbert, Saarland, Germany, 66386
    - Zentrum für klinische Studien
- Saxony
  - Dresden, Saxony, Germany, 1277
    - Hausärztlich-Kardiologisches MVZ am Felsenkeller GmbH/Zentrum für klinische Studien
  - Dresden, Saxony, Germany, 1307
    - Universitaetsklinikum Carl Gustav Carus Dresden
  - Leipzig, Saxony, Germany, 04177
    - Velocity Clinical Research Leipzig GmbH
  - Leipzig, Saxony, Germany, 04249
    - Gemeinschaftspraxis Dr. Taeschner/Dr. Bonigut
  - Leipzig, Saxony, Germany, 4107
    - AmBeNet GmbH
  - Pirna, Saxony, Germany, 1796
    - Private Practice - Dr. Christine Kosch
  - Riesa, Saxony, Germany, 1589
    - MVZ Riesa am Klinikum Döbeln GmbH
  - Zwenkau, Saxony, Germany, 04442
    - Praxis für Inner Medizin - Diabetologische Schwerpunktpraxis
- Saxony-Anhalt
  - Hohenmölsen, Saxony-Anhalt, Germany, 06679
    - Hausarzt- und Diabetologische Schwerpunktpraxis Hohenmölsen - Weiβenfels
  - Magdeburg, Saxony-Anhalt, Germany, 39120
    - SMO.MD GmbH
- Schleswig-Holstein
  - Lübeck, Schleswig-Holstein, Germany, 23562
    - Universität zu Lübeck - Institut für Endokrinologie und Diabetes
  - Oldenburg in Holstein, Schleswig-Holstein, Germany, 23758
    - RED-Institut GmbH
  - Reinfeld, Schleswig-Holstein, Germany, 23858
    - Private Practice - Dr. Joachim Weimer
- State of Berlin
  - Spandau, State of Berlin, Germany, 13597
    - Medizinisches Versorgungszentrum am Bahnhof Spandau
- Thuringia
  - Eisenach, Thuringia, Germany, 99817
    - Gemeinschaftspraxis für Diabetologie
Greece
- Attikí
  - Athens, Attikí, Greece, 11527
    - General Hospital of Athens "G. Gennimatas"
  - Chaïdári, Attikí, Greece, 12462
    - Attikon General University Hospital
- Attikí (Region)
  - Athens, Attikí (Region), Greece, 115 21
    - Athens Euroclinic
  - Palaió Fáliro, Attikí (Region), Greece, 17562
    - Iatriko Paleou Falirou Medical Center
- Kentrikí Makedonía
  - Thessaloniki, Kentrikí Makedonía, Greece, 54642
    - Ippokrateio General Hospital of Thessaloniki
- Thessaloníki
  - Thermi, Thessaloniki, Thessaloníki, Greece, 570 01
    - Thermi Clinic
  - Thessaloniki, Thessaloníki, Greece, 546 45
    - Euromedica General Clinic of Thessaloniki
  - Thessaloniki, Thessaloníki, Greece, 546 36
    - AHEPA University General Hospital of Thessaloniki
  - Thessaloniki, Thessaloníki, Greece, 564 03
    - Papageorgiou General Hospital of Thessaloniki
- Thessalía
  - Larissa, Thessalía, Greece, 41110
    - University General Hospital of Larissa
Hungary
- - Budapest, Hungary, 1032
    - Szent Margit Rendelőintézet Nonprofit Kft
  - Budapest, Hungary, H1171
    - Strazsahegy Medicina Bt.
  - Budapest, Hungary, 1125
    - Szent János Kórház
  - Budapest, Hungary, 1089
    - ClinDiab Kft.
  - Budapest, Hungary, 1134
    - Magyar Honvedseg Egeszsegugyi Kozpont
  - Debrecen, Hungary, 4032
    - Debreceni Egyetem Klinikai Kozpont
- Bács-Kiskun county
  - Kalocsa, Bács-Kiskun county, Hungary, 6300
    - Studium Egeszseghaz Kft
- Csongrád megye
  - Szeged, Csongrád megye, Hungary, 6725
    - Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont
- Fejér
  - Székesfehérvár, Fejér, Hungary, 8000
    - Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz
- Hajdú-Bihar
  - Debrecen, Hajdú-Bihar, Hungary, 4031
    - Debreceni Egyetem Kenézy Gyula Egyetemi Kórház
- Heves County
  - Eger, Heves County, Hungary, 3300
    - Markhot Ferenc Oktatókórház
  - Gyöngyös, Heves County, Hungary, 3200
    - Pharma 4 Trial
- Komárom-Esztergom
  - Komárom, Komárom-Esztergom, Hungary, 2900
    - Selye János Kórház
- Tolna County
  - Szekszárd, Tolna County, Hungary, 7100
    - CLINFAN Szolgáltató Kft
- Veszprém megye
  - Balatonfüred, Veszprém megye, Hungary, 8230
    - DRC Gyógyszervizsgáló Központ
- Zala County
  - Nagykanizsa, Zala County, Hungary, 8800
    - Kanizsai Dorottya Korhaz
  - Zalaegerszeg, Zala County, Hungary, 8900
    - Zala Megyei Szent Rafael Kórház
India
- Gujarat
  - Ahmedabad, Gujarat, India, 380052
    - Gujarat Endocrin Pvt Ltd
  - Ahmedabad, Gujarat, India, 380060
    - Marengo CIMS Hospital
- Karnataka
  - Bangalore, Karnataka, India, 560043
    - Bangalore Diabetes Centre
- Madhya Pradesh
  - Indore, Madhya Pradesh, India, 452008
    - CARE CHL-Hospitals
- Maharashtra
  - Mumbai, Maharashtra, India, 400008
    - Topiwala National Medical College & B. Y. L. Nair Charitable Hospital
  - Mumbai, Maharashtra, India, 400012
    - King Edward Memorial Hospital & Seth Gordhandas Sunderdas Medical College
  - Nagpur, Maharashtra, India, 440001
    - Kingsway Hospitals (Best Multispeciality Hospital in Nagpur)
- National Capital Territory of Delhi
  - New Delhi, National Capital Territory of Delhi, India, 110060
    - Sir Ganga Ram Hospital
  - New Delhi, National Capital Territory of Delhi, India, 110029
    - All India Institute of Medical Sciences
  - New Delhi, National Capital Territory of Delhi, India, 110002
    - G.B. Pant Institute of Postgraduate Medical Education & Research
  - New Delhi, National Capital Territory of Delhi, India, 110062
    - Batra Hospital and Medical Research Centre
- Tamil Nadu
  - Chennai, Tamil Nadu, India, 600086
    - Madras Diabetes Research Foundation
- Telangana
  - Hyderabad, Telangana, India, 500034
    - Care Hospitals Hyderabad- Banjara Hills
- West Bengal
  - Kolkata, West Bengal, India, 700054
    - Apollo Multispeciality Hospitals limited
Israel
- Central District
  - Holon, Central District, Israel, 5810001
    - Edith Wolfson Medical Center
  - Kfar Saba, Central District, Israel, 4428164
    - Meir Medical Center
  - Petah Tikva, Central District, Israel
    - Rabin Medical Center
  - Petah Tikva, Central District, Israel, 49202
    - Rabin Medical Center - Hasharon Campus
  - Ramat Gan, Central District, Israel, 5262100
    - Sheba Medical Center
  - Rehovot, Central District, Israel, 7610001
    - Kaplan Medical Center
- Jerusalem
  - Jerusalem, Jerusalem, Israel, 9112001
    - Hadassah Medical Center
  - Jerusalem, Jerusalem, Israel, 9013102
    - Shaare Zedek Medical Center
  - Jerusalem, Jerusalem, Israel, 9124001
    - Hadassah Mount Scopus Medical Centre
  - Jerusalem, Jerusalem, Israel, 93106
    - Clalit Health Services Diabetes and Endocrinology Clinic Jerusalem
- Northern District
  - Afula, Northern District, Israel, 1834111
    - Emek Medical Center
  - Hadera, Northern District, Israel, 3810101
    - Hillel Yaffe Medical Center
  - Haifa, Northern District, Israel, 3109601
    - Rambam Health Care Campus
  - Nahariya, Northern District, Israel, 2210001
    - Galilee Medical Center
  - Nazareth, Northern District, Israel, 16100
    - Holy Family Hospital
  - Safed, Northern District, Israel, 1311001
    - Ziv Medical Center
  - Sakhnin, Northern District, Israel, 3081000
    - Clalit Health Services - Sakhnin Community Clinic
- Southern District
  - Ashkelon, Southern District, Israel, 7830604
    - Barzilai Medical Center
  - Beersheba, Southern District, Israel, 8410101
    - Soroka Medical Center
- Tell Abīb
  - Tel Aviv, Tell Abīb, Israel, 6423906
    - Sourasky Medical Center
- Ḥeifā
  - Atlit, Ḥeifā, Israel, 30300
    - Clalit Health Services - Atlit
  - Haifa, Ḥeifā, Israel, 3515209
    - Linn Medical Center
  - Haifa, Ḥeifā, Israel, 3339419
    - Bnai Zion Medical Center
Italy
- - Bologna, Italy, 40138
    - IRCCS - AOU di Bologna
  - Catania, Italy, 95124
    - Azienda Ospedaliera Garibaldi
  - Catanzaro, Italy, 88100
    - Azienda Ospedaliera Mater Domini
  - Chieti, Italy, 66100
    - Università degli Studi Gabriele D' Annunzio
  - Milan, Italy, 20138
    - Centro Cardiologico Monzino
  - Parma, Italy, 43126
    - Azienda Ospedaliero Universitaria di Parma
  - Pavia, Italy, 27100
    - Fondazione Salvatore Maugeri Clinica del lavoro
- Apulia
  - Bari, Apulia, Italy, 70124
    - A.O.U.C. Policlinico di Bari
- Campania
  - Naples, Campania, Italy, 80138
    - Universita degli Studi della Campania Luigi Vanvitelli
- Lazio
  - Rome, Lazio, Italy, 133
    - Fondazione Policlinico Tor Vergata
  - Rome, Lazio, Italy, 186
    - Ospedale San Giovanni Calibita Fatebenefratelli
  - Rome, Lazio, Italy, 168
    - Fondazione Policlinico Universitario Agostino Gemelli
- Lombardy
  - Bergamo, Lombardy, Italy, 24127
    - Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII
  - Milan, Lombardy, Italy, 20122
    - Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
- Sardinia
  - Olbia, Sardinia, Italy, 7026
    - Ospedale san Giovanni di Dio-Diabetologia
- Sicily
  - Palermo, Sicily, Italy, 90129
    - A.O.U. Policlinico Paolo Giaccone
- Torino
  - Chieri, Torino, Italy, 10023
    - Ospedale Maggiore Pronto Soccorso
- Tuscany
  - Florence, Tuscany, Italy, 50134
    - Azienda Ospedaliera Universitaria Careggi
  - Pisa, Tuscany, Italy, 56124
    - Azienda Ospedaliera Universitaria Pisana
- Veneto
  - Verona, Veneto, Italy, 37126
    - Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento
Japan
- - Kumamoto, Japan, 862-0976
    - Jinnouchi Hospital
  - Osaka, Japan, 530-0001
    - AMC Nishiumeda Clinic
  - Osaka, Japan, 530-0005
    - Sakurabashi Watanabe Advanced Healthcare Hospital
- Kyoto
  - Uji, Kyoto, Japan, 611-0041
    - Uji-Tokushukai Medical Center
- Osaka
  - Takatsuki, Osaka, Japan, 569-1045
    - Takatsuki Red Cross Hospital
- Tokyo
  - Chuo-ku, Tokyo, Japan, 103-0027
    - Tokyo-Eki Center-building Clinic
  - Chuo-ku, Tokyo, Japan, 104-0031
    - Fukuwa Clinic
  - Chuo-ku, Tokyo, Japan, 103-0002
    - The Institute of Medical Science, Asahi Life Foundation
  - Ootaku, Tokyo, Japan, 143-0015
    - Medical Corporation Sato Medical clinic
Mexico
- - Aguascalientes, Mexico, 20116
    - Centro de Investigacion Medica Aguascalientes
  - Aguascalientes, Mexico, 20230
    - Hospital Cardiologica Aguescalientes
  - Aguascalientes, Mexico, 20230
    - Fundación Cardiovascular de Aguascalientes A.C.
  - Chihuahua City, Mexico, 31110
    - Investigacion En Salud Y Metabolismo S.C / Nutricion Clinica / Unidad de Base de Datos
  - Durango, Mexico, 34000
    - Lahoja. Asociacion Para La Investigacion Y La Farmacovigilancia
  - Querétaro, Mexico, 76000
    - Centro de Estudios Clínicos de Querétaro (CECLIQ)
- Estado de Baja California
  - Tijuana, Estado de Baja California, Mexico, 22500
    - Centro de Investigacion Cardiovascular y Metabólica
- Jalisco
  - Guadalajara, Jalisco, Mexico, 44130
    - Diseno y Planeacion en Investigacion Medica
  - Guadalajara, Jalisco, Mexico, 44150
    - Unidad de Investigaci�n Cl�nica Cardiometabolica de Occidente
  - Guadalajara, Jalisco, Mexico, 44340
    - Universidad de Guadalajara
  - Guadalajara, Jalisco, Mexico, 44860
    - Salud Cardiovascular
  - Guadalajara, Jalisco, Mexico, 44670
    - Private Practice - Dr. Arechavaleta Granell Maria del Rosario
  - Guadalajara, Jalisco, Mexico, 44160
    - Centro de Investigacion Medica Integral
  - Guadalajara, Jalisco, Mexico, 4460
    - Instituto Jalisciense de Investigación en Diabetes y Obesidad
  - Guadalajara, Jalisco, Mexico, 44260
    - Centro de Investigacion Medica de Occidente, S.C.
- Mexico City
  - Mexico City, Mexico City, Mexico, 11650
    - Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares
- Morelos
  - Cuernavaca, Morelos, Mexico, 62250
    - Instituto de Diabetes, Obesidad y Nutricion
- Nuevo León
  - Monterrey, Nuevo León, Mexico, 66460
    - Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
  - Monterrey, Nuevo León, Mexico, 64060
    - Cardiolink Clin Trials
  - San Nicolás de los Garza, Nuevo León, Mexico, 66465
    - Unidad Médica para la Salud Integral
- Sinaloa
  - Culiacán, Sinaloa, Mexico, 80230
    - Centro Para El Desarrollo de La Medicina Y de Asistencia Medica Especializada S.C.
- Tamaulipas
  - Ciudad Madero, Tamaulipas, Mexico, 89440
    - Centro de Estudios de Investigacion Metabolicos y Cardiovasculares
- Veracruz
  - Xalapa, Veracruz, Mexico, 91193
    - Hospital Angeles Xalapa
- Yucatán
  - Mérida, Yucatán, Mexico, 97070
    - Medical Care and Research SA de CV
Netherlands
- - Utrecht, Netherlands, 3584 CX
    - Universitair Medisch Centrum Utrecht
  - Utrecht, Netherlands, 3582 KE
    - Diakonessenhuis, locatie Utrecht
- Drenthe
  - Hoogeveen, Drenthe, Netherlands, 7909 AA
    - Ziekenhuis Bethesda
- Flevoland
  - Almere Stad, Flevoland, Netherlands, 1311RL
    - EB Utrecht
- Gelderland
  - Arnhem, Gelderland, Netherlands, 6815 AD
    - Ziekenhuis Rijnstate
  - Doetinchem, Gelderland, Netherlands, 7009 BL
    - Slingeland Ziekenhuis
  - Ede, Gelderland, Netherlands, 6716 RP
    - Ziekenhuis Gelderse Vallei
  - Nijmegen, Gelderland, Netherlands, 6525 GA
    - Radboudumc
  - Nijmegen, Gelderland, Netherlands, 6532 SZ
    - Canisius-Wilhelmina ziekenhuis
- North Brabant
  - 's-Hertogenbosch, North Brabant, Netherlands, 5223 GZ
    - Jeroen Bosch ziekenhuis
- North Holland
  - Amstelveen, North Holland, Netherlands, 1186 AM
    - Ziekenhuis Amstelland
  - Amsterdam, North Holland, Netherlands, 1105 AZ
    - Amsterdam UMC, locatie AMC
  - Amsterdam, North Holland, Netherlands, 1081 HV
    - Amsterdam UMC, Locatie VUMC
  - Haarlem, North Holland, Netherlands, 2035 RC
    - Spaarne Gasthuis, Haarlem Zuid
- Overijssel
  - Hardenberg, Overijssel, Netherlands, 7772 SE
    - Saxenburgh Medisch Centrum
- South Holland
  - Delft, South Holland, Netherlands, 2625 AD
    - Reinier de Graaf Ziekenhuis, locatie Delft
  - Dirksland, South Holland, Netherlands, 3247 BW
    - Het Van Weel-Bethesda Ziekenhuis - Ziekenhuis Dirksland
  - Rotterdam, South Holland, Netherlands, 3045 PM
    - Franciscus Gasthuis & Vlietland, Locatie Gasthuis
Poland
- Greater Poland Voivodeship
  - Poznan, Greater Poland Voivodeship, Poland, 60-111
    - OMEDICA Medical Center
  - Poznan, Greater Poland Voivodeship, Poland, 61-251
    - Gaja Poradnie Lekarskie Maciej Wiza
  - Poznan, Greater Poland Voivodeship, Poland, 61-655
    - Private Practice - Dr. Ewa Krzyzagorska
- Lesser Poland Voivodeship
  - Krakow, Lesser Poland Voivodeship, Poland, 31-261
    - Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-MET
  - Tarnów, Lesser Poland Voivodeship, Poland, 33-100
    - Private Practice - Dr. Robert Witek
- Lower Silesian Voivodeship
  - Wroclaw, Lower Silesian Voivodeship, Poland, 50-127
    - NZOZ Regionalna Poradnia Diabetologiczna
  - Wroclaw, Lower Silesian Voivodeship, Poland, 50-403
    - Wojewódzki Zespól Specjalistycznej Opieki Zdrowotnej
- Lublin Voivodeship
  - Lublin, Lublin Voivodeship, Poland, 20-044
    - CenterMed Lublin NZOZ
  - Lublin, Lublin Voivodeship, Poland, 20-333
    - Gabinety TERPA
  - Lublin, Lublin Voivodeship, Poland, 20-538
    - NZOZ Medica
- Masovian Voivodeship
  - Warsaw, Masovian Voivodeship, Poland, 02-117
    - Instytut Diabetologii
  - Warsaw, Masovian Voivodeship, Poland, 00-215
    - Centrum Medyczne AMED
  - Warsaw, Masovian Voivodeship, Poland, 02-677
    - ETG NETWORK Sp. z o.o.
- Podlaskie Voivodeship
  - Bialystok, Podlaskie Voivodeship, Poland, 15-404
    - Legeartis - Poradnie Specjalistyczne
  - Bialystok, Podlaskie Voivodeship, Poland, 15445
    - Niepubliczny Specjalistyczny Zaklad Opieki Zdrowotnej Osrodek Diabetologiczny Popula Spolka Cywilna
- Pomeranian Voivodeship
  - Gdansk, Pomeranian Voivodeship, Poland, 80-546
    - Centrum Badań Klinicznych PI-House sp. z o.o.
- Silesian Voivodeship
  - Katowice, Silesian Voivodeship, Poland, 40-772
    - NZOZ Salvia CM
  - Ruda Śląska, Silesian Voivodeship, Poland, 41-709
    - NZOZ Przychodnia Specjalistyczna Andrzej Wittek, Henryk Rudzki
- Łódź Voivodeship
  - Lodz, Łódź Voivodeship, Poland, 90338
    - Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna
Puerto Rico
- - Bayamón, Puerto Rico, 00959
    - Advanced Clinical Research, LLC
  - Manati, Puerto Rico, 00674
    - Manati Center for Clinical Research
  - Ponce, Puerto Rico, 00717
    - Research and Cardiovascular Corp.
  - San Juan, Puerto Rico, 00917
    - GCM Medical Group, PSC - Hato Rey Site
  - San Juan, Puerto Rico, 00935
    - San Juan City Hospital
Romania
- - Bacau, Romania, 600154
    - CMI Dr.Pletea Noemi SRL
  - Bacau, Romania, 600238
    - SC Minimed SRL
  - Galați, Romania, 800291
    - Diamed Obesity
  - Iași, Romania, 700514
    - Centrul Medical Consultmed
  - Iași, Romania, 400002
    - Olimpia Med
- Alba
  - Alba Iulia, Alba, Romania, 510134
    - Private Practice - Dr. Diana Barbonta
- Bihor County
  - Oradea, Bihor County, Romania, 410147
    - Diabdana
  - Oradea, Bihor County, Romania, 410159
    - Centrul Medical Grandmed
- Brașov County
  - Brasov, Brașov County, Romania, 500283
    - C.M.D.T.A. Neomed
- Bucharest
  - Bucharest, Bucharest, Romania, 10507
    - Nicodiab
  - Bucharest, Bucharest, Romania, 10627
    - Geea Medical Easy Diet
  - Bucharest, Bucharest, Romania, 13764
    - Centrul Medical NutriLife
  - Bucharest, Bucharest, Romania, 20475
    - The National Institute of Diabetes, Nutrition and Metabolic Diseases "Prof. Dr. N. Paulescu"
- Constanța County
  - Mangalia, Constanța County, Romania, 905500
    - Gama Diamed
- Dolj
  - Craiova, Dolj, Romania, 200678
    - Top Diabet SRL
- Maramureş
  - Baia Mare, Maramureş, Romania, 430222
    - CMI DNBM Dr. Pop Lavinia
- Mureș County
  - Târgu Mureş, Mureș County, Romania, 540098
    - SC Dentosim Queen SRL - Centrul Medical Diamed
- Prahova
  - Ploieşti, Prahova, Romania, 100163
    - Diabmed Dr. Popescu Alexandrina
  - Ploieşti, Prahova, Romania, 100561
    - Dianutrilife Medica
- Timiș County
  - Timișoara, Timiș County, Romania, 300456
    - Centru Medical Dr. Negrisanu
Russia
- Arkhangelskaya oblast
  - Arkhangelsk, Arkhangelskaya oblast, Russia, 163045
    - Arkhangelsk Regional Clinical Hospital
  - Arkhangelsk, Arkhangelskaya oblast, Russia, 163045
    - First City Clinical Hospital E.E. Volosevich
- Komi
  - Syktyvkar, Komi, Russia, 167000
    - Advisory Diagnostic Centre
- Leningradskaya Oblast'
  - Saint Petersburg, Leningradskaya Oblast', Russia, 191104
    - City Mariinskaya Hospital
- Moscow
  - Moscow, Moscow, Russia, 129110
    - M. F. Vladimirskiy Moscow Regional Research Clinical Institute
  - Moscow, Moscow, Russia, 101990
    - National Medical Research Center for therapy and preventive medicine
  - Moscow, Moscow, Russia, 117036
    - Endocrinology Research Center of Rosmedtechnologies
  - Moscow, Moscow, Russia, 117997
    - Pirogov Russian National Research Medical University
  - Moscow, Moscow, Russia, 119991
    - First Moscow State Medical University I.M. Sechenov
  - Moscow, Moscow, Russia, 121552
    - Russian Cardiology Research and Production Complex
  - Moscow, Moscow, Russia, 123182
    - Moscow City Clinical Hospital Number 52
  - Moscow, Moscow, Russia
    - Moscow City Clinical Hospital Number 52
- Novosibirsk Oblast
  - Novosibirsk, Novosibirsk Oblast, Russia, 630087
    - Novosibirsk State Medical University
- Rostov Oblast
  - Rostov-on-Don, Rostov Oblast, Russia, 344022
    - Rostov State Medical University
- Ryazan Oblast
  - Ryazan, Ryazan Oblast, Russia, 390026
    - Ryazan Regional Clinical Cardiological Dispensary
- Sankt-Peterburg
  - Saint Petersburg, Sankt-Peterburg, Russia, 195257
    - Saint-Petersburg City Hospital of Saint Elizabeth
  - Saint Petersburg, Sankt-Peterburg, Russia, 194044
    - S.M. Kirov Military Medical Academy
  - Saint Petersburg, Sankt-Peterburg, Russia, 199226
    - Astarta Clinic
- Saratov Oblast
  - Saratov, Saratov Oblast, Russia, 410053
    - Regional Clinical Hospital of the Saratov Region
- Tomsk Oblast
  - Tomsk, Tomsk Oblast, Russia, 634063
    - Tomsk Regional Clinical Hospital
  - Tomsk, Tomsk Oblast, Russia
    - Siberian State Medical University
- Yaroslavl Oblast
  - Yaroslavl, Yaroslavl Oblast, Russia, 150003
    - Research & Practice
  - Yaroslavl, Yaroslavl Oblast, Russia, 150010
    - Yaroslavl State Med Acad Clinical Hospital
Slovakia
- Banská Bystrica Region
  - Lučenec, Banská Bystrica Region, Slovakia, 984 01
    - IN-DIA
- Bratislava Region
  - Bratislava, Bratislava Region, Slovakia, 831 01
    - Diacrin s.r.o.
  - Malacky, Bratislava Region, Slovakia, 901 01
    - Sin Azucar
- Košice Region
  - Rožňava, Košice Region, Slovakia, 048 01
    - DIAB sro
- Nitra Region
  - Nové Zámky, Nitra Region, Slovakia, 940 01
    - Funkystuff
- Presov
  - Prešov, Presov, Slovakia, 080 01
    - Diabetol
  - Sabinov, Presov, Slovakia, 8301
    - MED-DIA s.r.o
- Trenčín Region
  - Púchov, Trenčín Region, Slovakia, 020 01
    - DIA-MED CENTRUM s.r.o.
  - Trenčín, Trenčín Region, Slovakia, 911 01
    - Diabetes Centrum
South Korea
- Kang-won-do
  - Wŏnju, Kang-won-do, South Korea, 26426
    - Yonsei University-Wonju Severance Christian Hospital
- Seoul-teukbyeolsi [Seoul]
  - Seoul, Seoul-teukbyeolsi [Seoul], South Korea, 3080
    - Seoul National University Hospital
  - Seoul, Seoul-teukbyeolsi [Seoul], South Korea, 3722
    - Severance Hospital, Yonsei University Health System
  - Seoul, Seoul-teukbyeolsi [Seoul], South Korea, 5505
    - Asan Medical Center
  - Seoul, Seoul-teukbyeolsi [Seoul], South Korea, 6591
    - The Catholic Univ. of Korea Seoul St. Mary's Hospital
  - Seoul, Seoul-teukbyeolsi [Seoul], South Korea, 2841
    - Korea University Anam Hospital
  - Seoul, Seoul-teukbyeolsi [Seoul], South Korea, 5278
    - Kyung Hee University Hospital at Gangdong
  - Seoul, Seoul-teukbyeolsi [Seoul], South Korea, 7441
    - Hallym University Kangnam Sacred Heart Hospital
- Taegu-Kwangyǒkshi
  - Daegu, Taegu-Kwangyǒkshi, South Korea, 42601
    - Keimyung University Dongsan Hospital
- Ulsan-Kwangyǒkshi
  - Ulsan, Ulsan-Kwangyǒkshi, South Korea, 44033
    - Ulsan university hospital
Spain
- - Granada, Spain, 18012
    - Hospital Unviersitario Virgen Nieves
  - Madrid, Spain, 28046
    - Hospital Universitario La Paz
  - Seville, Spain, 41003
    - Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)
  - Seville, Spain, 41009
    - Hospital Universitario Virgen Macarena
  - Valencia, Spain, 46026
    - Hospital Universitari i Politecnic La Fe
- A Coruña [La Coruña]
  - A Coruña, A Coruña [La Coruña], Spain, 15006
    - CHUAC-Complejo Hospitalario Universitario A Coruña
  - Ferrol, A Coruña [La Coruña], Spain, 15405
    - Complejo Hospitalario Universitario de Ferrol (CHUF)- Hospital Naval
  - Santiago de Compostela, A Coruña [La Coruña], Spain, 15706
    - CHUS - Hospital Clinico Universitario
- Almería
  - Almería, Almería, Spain, 4009
    - Centro Periferico De Especialidades Bola Azul
- Andalusia
  - Málaga, Andalusia, Spain, 29010
    - Hospital Universitario Virgen de la Victoria
  - Seville, Andalusia, Spain, 41010
    - Hospital Quiron Infanta Luisa
- Asturias, Principado de
  - Oviedo, Asturias, Principado de, Spain, 33011
    - Hospital Universitario Central de Asturias
- Castille and León
  - Valladolid, Castille and León, Spain, 47003
    - Hospital Clínico Universitario de Valladolid
- Cádiz
  - Sanlúcar de Barrameda, Cádiz, Spain, 11540
    - Hospital Virgen del Camino
  - Villamartín, Cádiz, Spain, 11650
    - Hospital Virgen de las Montañas
- Madrid
  - Pozuelo de Alarcón, Madrid, Spain, 28223
    - Hospital Universitario Quironsalud Madrid
- Madrid, Comunidad de
  - Alcalá de Henares, Madrid, Comunidad de, Spain, 28805
    - Hospital Universitario Príncipe de Asturias
  - Madrid, Madrid, Comunidad de, Spain, 28034
    - Hospital Universitario Ramón y Cajal
- Valenciana, Comunitat
  - Valencia, Valenciana, Comunitat, Spain, 46014
    - Hospital General Universitario de Valencia
- València
  - Alzira, València, Spain, 46600
    - Hospital Universitario de La Ribera
Sweden
- Dalarnas Län [se-20]
  - Rättvik, Dalarnas Län [se-20], Sweden, 795 30
    - Dalecarlia Clinical Research Center
- Jämtlands Län [se-23]
  - Östersund, Jämtlands Län [se-23], Sweden, 831 31
    - Östersunds Sjukhus
- Skåne Län [se-12]
  - Lund, Skåne Län [se-12], Sweden, 222 22
    - ProbarE
- Stockholms Län [se-01]
  - Stockholm, Stockholms Län [se-01], Sweden, 112 21
    - Citydiabetes
- Västra Götalands Län [se-14]
  - Mölndal, Västra Götalands Län [se-14], Sweden, 431 80
    - Sahlgrenska Universitetssjukhuset Mölndal
- Örebro Län [se-18]
  - Örebro, Örebro Län [se-18], Sweden, 701 85
    - Universitetssjukhuset Orebro
Taiwan
- - Taichung, Taiwan, 407
    - Taichung Veterans General Hospital
  - Tainan, Taiwan, 704
    - National Cheng-Kung Uni. Hosp.
  - Taipei, Taiwan, 11217
    - Taipei Veterans General Hospital
  - Taoyuan, Taiwan, 333
    - Chang Gung Medical Foundation-Linkou Branch
- Changhua
  - Changhua County, Changhua, Taiwan, 50006
    - Changhua Christian Hospital
- Hsinchu
  - Hsinchu, Hsinchu, Taiwan, 300
    - Mackay Memorial Hospital-Hsinchu
- Hualien
  - Hualien City, Hualien, Taiwan, 970
    - Hualien Tzu Chi Medical Center
- Kaohsiung
  - Kaohsiung Niao Sung Dist, Kaohsiung, Taiwan, 83301
    - Chang Gung Memorial Hospital at Kaohsiung
- Tainan
  - Tainan, Tainan, Taiwan, 71004
    - Chi Mei Medical Center
Turkey (Türkiye)
- - Antalya, Turkey (Türkiye), 7070
    - Akdeniz Universitesi Hastanesi
  - Aydin, Turkey (Türkiye), 9100
    - Adnan Menderes University Medical Faculty
  - Denizli, Turkey (Türkiye)
    - Pamukkale University Medical Faculty, Fahri Goksin Oncology Centre
  - Erzurum, Turkey (Türkiye), 25070
    - Atatürk Üniversitesi
  - Gaziantep, Turkey (Türkiye), 27000
    - Gaziantep Üniversitesi Gaziantep Onkoloji Hastanesi
  - Istanbul, Turkey (Türkiye), 34010
    - Koc Universitesi Hastanesi
  - Istanbul, Turkey (Türkiye), 34303
    - Acibadem Universitesi Atakent Hastanesi
  - Istanbul, Turkey (Türkiye), 34752
    - Fatih Sultan Mehmet Training and Research Hospital
  - Istanbul, Turkey (Türkiye), 34147
    - Dr. Sadi Konuk Egitim ve Arastirma Hastanesi
  - Istanbul, Turkey (Türkiye), 34722
    - Göztepe Eitim Ve Aratrma Hastanesi
  - Kayseri, Turkey (Türkiye), 38030
    - Erciyes University Medical Faculty
  - Kocaeli, Turkey (Türkiye), 41380
    - Kocaeli Üniversitesi
  - Malatya, Turkey (Türkiye), 44280
    - Inonu Universitesi Turgut Ozal Tıp Merkezi
- Adana
  - Yüreğir, Adana, Turkey (Türkiye), 01250
    - Baskent University Dr. Turgut Noyan Research and Training Center
- Diyarbakır
  - Sur, Diyarbakır, Turkey (Türkiye), 21200
    - Dicle Üniversitesi
- Eskişehir
  - Eskişehir, Eskişehir, Turkey (Türkiye), 26040
    - Eskisehir Osmangazi University
- Mersin
  - Yenişehir, Mersin, Turkey (Türkiye), 33110
    - Mersin University Medical Faculty
- İzmir
  - Balçova, İzmir, Turkey (Türkiye), 35340
    - Dokuz Eylul Universitesi
  - Bornova, İzmir, Turkey (Türkiye), 35100
    - Ege Universitesi Hastanesi
Ukraine
- - Kyiv, Ukraine, 02091
    - Medical Center Ok!Clinic+
- Chernivetska Oblast
  - Chernivtsi, Chernivetska Oblast, Ukraine, 58000
    - Regional Communal Non-commercial enterprise "Chernivtsi regional clinical hospital"
- Dnipropetrovsk Oblast
  - Dnipro, Dnipropetrovsk Oblast, Ukraine, 49023
    - Dnipropetrovsk City Clinical Hospital No. 9
  - Dnipro, Dnipropetrovsk Oblast, Ukraine, 49027
    - Ukrainian State Research Institute Of Medical And Social Problems Of Disability
- Kharkiv Oblast
  - Kharkiv, Kharkiv Oblast, Ukraine, 61037
    - City Clinical Hospital No. 2
  - Kharkiv, Kharkiv Oblast, Ukraine, 61039
    - L.T. Mala National Institute of Therapy of NAMS of Ukraine
  - Kharkiv, Kharkiv Oblast, Ukraine, 61176
    - Municipal Non-Profit Enterprise "City clinical hospital №8" of Kharkiv city council
- Kyiv Oblast
  - Kiev, Kyiv Oblast, Ukraine, 4050
    - Medical Center of Limited Liability Company "Medical Center "Consilium Medical"
  - Kiev, Kyiv Oblast, Ukraine, 04114
    - Institute of Endocrinology and Metabolism named after Komissarenko
  - Kiev, Kyiv Oblast, Ukraine, 4114
    - Institute of Endocrinology and Metabolism named after Komissarenko
- Kyivska Oblast
  - Kiev, Kyivska Oblast, Ukraine, 04050
    - ARTEM
  - Kyiv, Kyivska Oblast, Ukraine, 3037
    - Medbud Clinic
- Lviv Oblast
  - Lviv, Lviv Oblast, Ukraine, 79000
    - Branch "Center of Endocrinological Health" of "Lviv Regional Clinical Diagnostic Center"
  - Lviv, Lviv Oblast, Ukraine, 79011
    - Lviv City Clinical Hospital #4
- Odesa Oblast
  - Odesa, Odesa Oblast, Ukraine, 65025
    - Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council
  - Odesa, Odesa Oblast, Ukraine, 65114
    - Municipal non-profit enterprise "Consultative-diagnostic center №20" of Odesa city council
- Poltava Oblast
  - Poltava, Poltava Oblast, Ukraine, 36011
    - Poltova Oblast Clinical Hospital IM.M.V.Sklifosovskoho
  - Poltava, Poltava Oblast, Ukraine, 36038
    - Municipal enterprise "1st City clinical hospital of Poltava City Council", Poltava State Medical University
- Sumska Oblast
  - Sumy, Sumska Oblast, Ukraine, 40031
    - Municipal Non-Profit Enterprise Of Sumy Regional Council ''Sumy Regional Clinical Hospital''
- Vinnytsia Oblast
  - Vinnytsia, Vinnytsia Oblast, Ukraine, 21010
    - Vinnytsia Regional Clinical Endocrinology Dispensary
- Zaporizhzhia Oblast
  - Zaporizhzhya, Zaporizhzhia Oblast, Ukraine, 69118
    - Municipal non-profit enterprise "City Hospital #7" of Zaporizhzhia City Council
United Kingdom
- - Liverpool, United Kingdom, L9 7AL
    - University Hospital Aintree
- Aberdeen City
  - Aberdeen, Aberdeen City, United Kingdom, AB25 2ZN
    - Aberdeen Royal Infirmary
- Angus
  - Dundee, Angus, United Kingdom, DD1 9SY
    - Ninewells Hospital and Medical School
- Bristol, City of
  - Bristol, Bristol, City of, United Kingdom, BS10 5NB
    - Southmead Hospital
- Cambridgeshire
  - Ely, Cambridgeshire, United Kingdom, CB7 5JD
    - Staploe Medical Centre
- Devon
  - Plymouth, Devon, United Kingdom, PL5 3JB
    - Knowle House Surgery
- England
  - Truro, England, United Kingdom, TR1 3LJ
    - The Royal Cornwall Hospital
- Glasgow City
  - Glasgow, Glasgow City, United Kingdom, G4 0SF
    - Glasgow Royal Infirmary
- Kingston Upon Hull
  - Hull, Kingston Upon Hull, United Kingdom, HU3 2JZ
    - Hull Royal Infirmary
- Leicestershire
  - Leicester, Leicestershire, United Kingdom, LE5 4PW
    - Leicester General Hospital
- Suffolk
  - Ipswich, Suffolk, United Kingdom, IP4 5PD
    - Ipswich Hospital
- Swansea [Abertawe Gb-ata]
  - Swansea, Swansea [Abertawe Gb-ata], United Kingdom, SA6 6SG
    - Morriston Hospital
United States
- Alabama
  - Birmingham, Alabama, United States, 35294-0012
    - University of Alabama at Birmingham Medical Center
- California
  - Concord, California, United States, 94520
    - John Muir Medical Center - Concord Campus
  - Covina, California, United States, 91723
    - Valley Clinical Trials, Inc.
  - Escondido, California, United States, 92025
    - AMCR Institute
  - Fresno, California, United States, 93720
    - Valley Research
  - Greenbrae, California, United States, 94904
    - NorCal Medical Research, Inc
  - La Jolla, California, United States, 92037
    - UCSD - Altman Clinical and Translational Research Institute (ACTRI)
  - Lancaster, California, United States, 93534
    - First Valley Medical Group
  - Monterey, California, United States, 93940
    - Monterey Endocrine & Diabetes Institute, Inc.
  - Moreno Valley, California, United States, 92555
    - Riverside University Health System - Medical Center
  - Orange, California, United States, 92868
    - Diabetes Associates Medical Group
  - Pasadena, California, United States, 91105
    - Pasadena Clinical Research
  - San Carlos, California, United States, 94070
    - LCGK Research
  - San Ramon, California, United States, 94583
    - Norcal Endocrinology & Internal Medicine
  - Torrance, California, United States, 90502
    - Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Colorado
  - Aurora, Colorado, United States, 80045
    - University of Colorado Anschutz Medical Campus
- Connecticut
  - Hamden, Connecticut, United States, 06517
    - CMR of Greater New Haven, LLC
  - Waterbury, Connecticut, United States, 06708
    - Chase Medical Research, LLC
- Florida
  - Altamonte Springs, Florida, United States, 32714
    - Orlando Heart & Vascular Institute, LLC
  - Boca Raton, Florida, United States, 33434
    - Excel Medical Clinical Trials
  - Hollywood, Florida, United States, 33024
    - Encore Medical Research
  - Jacksonville, Florida, United States, 32216
    - Jacksonville Center for Clinical Research
  - Jacksonville, Florida, United States, 32204
    - East Coast Institute for Research, LLC
  - Largo, Florida, United States, 33777
    - Accel Research Sites - St. Pete-Largo Clinical Research Unit
  - Ocala, Florida, United States, 34474
    - Ocala Caridovascular Research
  - Palm Beach Gardens, Florida, United States, 33410
    - Cardiology Partners Clinical Research Institute - Palm Beach Gardens
  - Port Charlotte, Florida, United States, 33952
    - Peace River Cardiovascular Center
  - St. Petersburg, Florida, United States, 33713
    - Professional Health Care of Pinellas
  - Wellington, Florida, United States, 33449
    - Cardiology Partners Clinical Research Institute - Wellington
  - Winter Haven, Florida, United States, 33880
    - Clinical Research of Central Florida
- Georgia
  - Atlanta, Georgia, United States, 30318
    - Atlanta Diabetes Associates
  - Duluth, Georgia, United States, 30096
    - Kaiser Permanente - Dutluth, GA
  - Johns Creek, Georgia, United States, 30024
    - Nsc Research
  - Lawrenceville, Georgia, United States, 30045
    - Physicians Research Associates
  - Macon, Georgia, United States, 31210
    - East Coast Institute for Research at The Jones Center
  - Tucker, Georgia, United States, 30084
    - Atlanta Heart Specialists
- Hawaii
  - Honolulu, Hawaii, United States, 96814
    - East-West Medical Research Institute
  - Honolulu, Hawaii, United States, 96819
    - VA Pacific Islands Health Care System
- Idaho
  - Blackfoot, Idaho, United States, 83221
    - Elite Clinical Trials
  - Idaho Falls, Idaho, United States, 83404
    - Rocky Mountain Clinical Research
- Illinois
  - Arlington Heights, Illinois, United States, 60005
    - Northwest Heart Clinical Research
  - Chicago, Illinois, United States, 60607
    - Cedar-Crosse Research Center
  - Gurnee, Illinois, United States, 60031
    - Clinical Investigation Specialists
  - Springfield, Illinois, United States, 62711
    - Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative
- Iowa
  - Iowa City, Iowa, United States, 52242
    - University of Iowa
  - West Des Moines, Iowa, United States, 50266
    - Iowa Diabetes and Endocrinology Research Center
- Kansas
  - Fairway, Kansas, United States, 66205
    - The University of Kansas - Clinical Research Center
  - Topeka, Kansas, United States, 66606
    - Cotton O'Neil Mulvane
  - Topeka, Kansas, United States, 66606
    - Cotton O'Neil Diabetes & Endocrinology
- Kentucky
  - Bowling Green, Kentucky, United States, 42101
    - Qualmedica Research
  - Louisville, Kentucky, United States, 40213
    - L-MARC Research Center
  - Owensboro, Kentucky, United States, 42301
    - Qualmedica Research, LLC
- Maryland
  - Baltimore, Maryland, United States, 21229
    - Ascension Saint Agnes Heart Care
  - Hyattsville, Maryland, United States, 20782
    - MedStar Health Research Institute (MedStar Physician Based Research Network)
  - Oxon Hill, Maryland, United States, 20745
    - MD Medical Research
  - Rockville, Maryland, United States, 20852
    - Endocrine and Metabolic Consultants
- Massachusetts
  - Boston, Massachusetts, United States, 02215
    - Joslin Diabetes Center
  - Boston, Massachusetts, United States, 02115
    - Brigham and Women's Hospital Diabetes Program
  - Methuen, Massachusetts, United States, 01844
    - ActivMed Practices and Research
  - North Dartmouth, Massachusetts, United States, 02747
    - Infinity Medical Research
- Michigan
  - Troy, Michigan, United States, 48098
    - Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
- Minnesota
  - Edina, Minnesota, United States, 55435
    - St. John's Hospital
  - Maplewood, Minnesota, United States, 55109
    - M Health Fairview St. John's Hospital
  - Saint Cloud, Minnesota, United States, 56303
    - CentraCare Heart & Vascular Center
- Missouri
  - City of Saint Peters, Missouri, United States, 63303
    - StudyMetrix Research
  - Springfield, Missouri, United States, 65807
    - Clinvest Research LLC
  - Springfield, Missouri, United States, 65807
    - Mercy Research - Smith Glynn Callaway
- Montana
  - Billings, Montana, United States, 59101
    - Billings Clinic
  - Butte, Montana, United States, 59701
    - Mercury Street Medical Group, PLLC
- Nebraska
  - Omaha, Nebraska, United States, 68198-4130
    - University of Nebraska Medical Center
  - Omaha, Nebraska, United States, 68105
    - VA Nebraska-Western Iowa Health Care System
- Nevada
  - Las Vegas, Nevada, United States, 89148
    - Palm Research Center Sunset
  - Las Vegas, Nevada, United States, 89128
    - Palm Research Center Tenaya
- New Hampshire
  - Nashua, New Hampshire, United States, 03060
    - Southern Nh Diabetes and Endocrinology
- New York
  - Albany, New York, United States, 12203
    - Albany Medical College, Division of Community Endocrinology
  - Westfield, New York, United States, 14787
    - Great Lakes Medical Research, LLC
- North Carolina
  - Charlotte, North Carolina, United States, 28207
    - Atrium Health - Department of Family Medicine Research
  - Durham, North Carolina, United States, 27710
    - Duke University
  - Mooresville, North Carolina, United States, 28117
    - PMG Research Inc., d/b/a PMG of Piedmont Healthcare
  - Wilmington, North Carolina, United States, 24801
    - Accellacare - Wilmington
- North Dakota
  - Fargo, North Dakota, United States, 58104
    - Lillestol Research
- Ohio
  - Cleveland, Ohio, United States, 44195
    - Cleveland Clinic Foundation
- Oklahoma
  - Norman, Oklahoma, United States, 73069
    - Alliance for Multispecialty Research, LLC
- Pennsylvania
  - Beaver, Pennsylvania, United States, 15009
    - Heritage Valley Medical Group, Inc.
  - Camp Hill, Pennsylvania, United States, 17011
    - Capital Area Research, LLC
  - Feasterville, Pennsylvania, United States, 19053
    - Decpa, Llc
  - Philadelphia, Pennsylvania, United States, 19114
    - Northeast Endocrine Metabolic Associates
  - Philadelphia, Pennsylvania, United States, 19107
    - Thomas Jefferson University - Clinical Research Institute
  - Pittsburgh, Pennsylvania, United States, 15236
    - Preferred Primary Care Physicians, Preferred Clinical Research (Ofc 18)
  - Yardley, Pennsylvania, United States, 19067
    - Cardiology Consultants of Philadelphia Yardley
- South Carolina
  - Charleston, South Carolina, United States, 29401
    - Ralph H. Johnson VA Medical Center
  - Greenville, South Carolina, United States, 29607
    - Tribe Clinical Research, LLC
  - Mt. Pleasant, South Carolina, United States, 29464
    - Accellacare - Mt Pleasant
- South Dakota
  - Rapid City, South Dakota, United States, 57701
    - Monument Health Rapid City Hospital
- Tennessee
  - Bristol, Tennessee, United States, 37620
    - Holston Medical Group
  - Knoxville, Tennessee, United States, 37938
    - PMG Research, Inc. d/b/a PMG Research of Knoxville
  - Memphis, Tennessee, United States, 38119
    - Endocrine Clinic
- Texas
  - Corpus Christi, Texas, United States, 78414
    - Private Practice - Dr. Osvaldo A. Brusco
  - Dallas, Texas, United States, 75230
    - Dallas Diabetes Research Center
  - Dallas, Texas, United States, 75231
    - Research Institute Of Dallas
  - Dallas, Texas, United States, 75251
    - Galenos Research
  - Dallas, Texas, United States, 75231
    - North Texas Endocrine Center
  - Dallas, Texas, United States, 75231
    - Texas Health Physicians Group
  - El Paso, Texas, United States, 79935
    - Academy of Diabetes, Thyroid and Endocrine
  - Fort Worth, Texas, United States, 76132
    - Diabetes and Thyroid Center of Ft. Worth
  - Houston, Texas, United States, 77070
    - Northwest Houston Cardiology - Cypress
  - Mesquite, Texas, United States, 75149
    - Southern Endocrinology Associates
  - North Richland Hills, Texas, United States, 76180
    - North Hills Family Medicine/North Hills Medical Research
  - San Antonio, Texas, United States, 75231
    - Audie L Murphy VA Hospital
  - Shavano Park, Texas, United States, 78231
    - Consano Clinical Research, LLC
  - Tomball, Texas, United States, 77375
    - Northwest Houston Heart Center
- Utah
  - Draper, Utah, United States, 84020
    - Physicians' Research Options
  - Ogden, Utah, United States, 84405
    - Advanced Research Institute
  - Salt Lake City, Utah, United States, 84102
    - Alpine Medical Group
  - West Valley City, Utah, United States, 84120
    - Kalo Clinical Research
- Virginia
  - Falls Church, Virginia, United States, 22042
    - Virginia Heart
- Washington
  - Puyallup, Washington, United States, 98372
    - MultiCare Good Samaritan Hospital
  - Seattle, Washington, United States, 98108
    - VA Puget Sound Health Care System
  - Spokane, Washington, United States, 99202
    - MultiCare Institute for Research and Innovation
  - Wenatchee, Washington, United States, 98801
    - Central Washington Health Services Association d/b/a Confluence Health
- Wisconsin
  - Kenosha, Wisconsin, United States, 53144
    - Clinical Investigation Specialists

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

40 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Description

Inclusion Criteria:

Men or women at least 40 years old with a diagnosis of type 2 diabetes
Established cardiovascular disease, including at least 1 of the following:
- Coronary artery disease (CAD) with any of the following:
  - Documented history of spontaneous myocardial infarction (MI)
  - ≥50% stenosis in 1 or more major coronary arteries, determined by invasive angiography
  - ≥50% stenosis in 2 or more major coronary arteries, determined by computed tomography coronary angiography (CTCA)
  - History of surgical or percutaneous coronary revascularization procedure
- Cerebrovascular disease - any of the following:
  - Documented history of ischemic stroke
  - Carotid arterial disease with ≥50% stenosis, documented by carotid ultrasound, magnetic resonance imaging (MRI), or angiography
  - Carotid stenting or surgical revascularization
- Peripheral arterial disease with either of the following:
  - Intermittent claudication and ankle-brachial index <0.9
  - Prior nontraumatic amputation or peripheral vascular procedure (eg, stenting or surgical revascularization), due to peripheral arterial ischemia
- Note: Supporting medical documentation is required in all instances
HbA1c ≥7% (≥53 mmol/mol) and ≤10.5% (≤91.3 mmol/mol) based on central laboratory assessment at screening
Body mass index (BMI) ≥25 kg/m2
At the time of signing the informed consent: Contraceptive use by men or women should be consistent with local regulations regarding the methods of contraception for those participating in clinical trials.
- Male patients: Men, regardless of their fertility status, with nonpregnant women of childbearing potential (WOCBP) partners must agree to either remain abstinent (if this is their preferred and usual lifestyle) or use condoms, as well as 1 additional highly effective (less than 1% failure rate) method of contraception (such as combination oral contraceptives, implanted contraceptives, or intrauterine devices) or effective method of contraception (such as diaphragms with spermicide or cervical sponges) for the duration of the study and until their plasma concentrations are below the level that could result in a relevant potential exposure to a possible fetus, predicted to be 90 days following the last dose of study drug.
  - Men and their partners may choose to use a double-barrier method of contraception. (Barrier protection methods without concomitant use of a spermicide are not an effective or acceptable method of contraception. Thus, each barrier method must include use of a spermicide. It should be noted, however, that the use of male and female condoms as a double barrier method is not considered acceptable due to the high failure rate when these barrier methods are combined).
  - Periodic abstinence (eg, calendar, ovulation, symptothermal, or postovulation methods), declaration of abstinence just for the duration of a trial, and withdrawal are not acceptable methods of contraception.
- Men with pregnant partners should use condoms during intercourse for the duration of the study and until the end of the estimated relevant potential exposure in WOCBP (90 days). Men should refrain from sperm donation for the duration of the study and until their plasma concentrations are below the level that could result in a relevant potential exposure to a possible fetus, predicted to be 90 days following the last dose of study drug. Men who are in exclusively same-sex relationships (as their preferred and usual lifestyle) are not required to use contraception.
- Female patients: Women of childbearing potential who are abstinent (if this is complete abstinence, as their preferred and usual lifestyle) or in a same-sex relationship (as part of their preferred and usual lifestyle) must agree to either remain abstinent or stay in a same-sex relationship without sexual relationships with males. Periodic abstinence (eg, calendar, ovulation, symptothermal, or postovulation methods), declaration of abstinence just for the duration of a trial, and withdrawal are not acceptable methods of contraception. Otherwise, WOCBP participating must agree to use 2 forms of effective contraception, where at least 1 form is highly effective (less than 1% failure rate), for the entirety of the study. Contraception must continue following completion of study drug administration for the entirety of the study and for 30 days thereafter.
  - WOCBP participating must test negative for pregnancy prior to initiation of treatment as indicated by a negative serum pregnancy test at the screening visit followed by a negative urine pregnancy test within 24 hours prior to exposure.
  - Two forms of effective contraception, where at least 1 form is highly effective, (such as combination oral contraceptives, implanted contraceptives, or intrauterine devices) will be used. Effective contraception (such as male or female condoms with spermicide, diaphragms with spermicide, or cervical sponges) may be used as the second therapy. Barrier protection methods without concomitant use of a spermicide are not a reliable or acceptable method. Thus, each barrier method must include use of a spermicide (ie, condom with spermicide, diaphragm with spermicide, or female condom with spermicide). It should be noted that the use of male and female condoms as a double barrier method is not considered acceptable due to the high failure rate when these methods are combined.
- Women not of childbearing potential may participate and include those who are:
  - infertile due to surgical sterilization (hysterectomy, bilateral oophorectomy, or tubal ligation), congenital anomaly such as mullerian agenesis, or
  - postmenopausal - defined as either: A woman at least 40 years of age with an intact uterus, not on hormone therapy, who has cessation of menses for at least 1 year without an alternative medical cause, AND a follicle-stimulating hormone >40 mIU/mL; or ii. A woman 55 or older not on hormone therapy, who has had at least 12 months of spontaneous amenorrhea; or A woman at least 55 years of age with a diagnosis of menopause prior to starting hormone replacement therapy.
In the investigator's opinion, are well motivated, capable, and willing to:
- learn how to self-inject treatment (tirzepatide or dulaglutide), as required for this protocol (visually impaired persons who are not able to perform the injections must have the assistance of a sighted individual trained to inject the study drug; persons with physical limitations who are not able to perform the injections must have the assistance of an individual trained to inject the study drug),
- inject study drug weekly,
- have a sufficient understanding of 1 of the provided languages of the country such that they will be able to complete the patient questionnaires, and
- make themselves available for the duration of the study, and who will comply with the required study visits.
Capable of giving signed informed consent

Exclusion Criteria:

Have type 1 diabetes mellitus
Have uncontrolled diabetes requiring immediate therapy (such as diabetic ketoacidosis) at screening or randomization, in the judgment of the physician
Have had 1 or more events of severe hypoglycemia and/or 1 or more events of hypoglycemia unawareness within 6 months prior to screening
Are currently planning treatment for diabetic retinopathy and/or macular edema.
Have been hospitalized for congestive heart failure (CHF) within 2 months prior to screening
Have chronic New York Heart Association Functional Classification IV CHF
Are currently planning a coronary, carotid, or peripheral artery revascularization
Had chronic or acute pancreatitis any time prior to screening, irrespective of etiology
Have a known clinically significant gastric emptying abnormality such as severe gastroparesis or gastric outlet obstruction, or have undergone or currently planning any gastric bypass (bariatric) surgery or restrictive bariatric surgery
Have acute or chronic hepatitis, signs or symptoms of any other liver disease, an alanine aminotransferase (ALT) level ≥3 times the upper limit of normal (ULN) for the reference range, as determined by the central laboratory (Note: Patients with nonalcoholic fatty liver disease are eligible to participate if their ALT level is <3 times the ULN for the reference range)
Have known chronic severe renal failure (defined as a known estimated glomerular filtration rate (eGFR) <15 mL/minute/1.73 m2) or are on chronic dialysis
Have evidence of a significant, uncontrolled endocrine abnormality (eg, thyrotoxicosis or adrenal crises)
Have a family or personal history of multiple endocrine neoplasia type 2 (MEN2) or familial medullary thyroid carcinoma (MTC) or personal history of nonfamilial MTC
Have a serum calcitonin level at screening of: (based on central laboratory results)
- ≥20 ng/L at Visit 1, if eGFR ≥60 mL/min/1.73 m2, or
- ≥35 ng/L at Visit 1, if eGFR <60 mL/min/1.73 m2
Have a history of an active or untreated malignancy or are in remission from a clinically significant malignancy for less than 5 years. An exception for this criterion is basal or squamous cell skin cancer, in situ carcinomas of the cervix, or in situ prostate cancer
Have a history of any other condition (such as known drug or alcohol abuse or psychiatric disorder) that, in the opinion of the investigator, may preclude the patient from following and completing the protocol
Have had a transplanted organ (corneal transplants [keratoplasty] allowed) or awaiting an organ transplant
Have any other condition (eg, hypersensitivity) that is a contraindication to any incretin or glucagon-like peptide-1 (GLP-1) receptor agonist (RA)
Have had an MI, percutaneous coronary revascularization procedure, ischemic stroke, carotid stenting or surgical revascularization, nontraumatic amputation, or peripheral vascular procedure (eg, stenting or surgical revascularization) less than 60 days prior to screening
Have had coronary artery bypass graft surgery less than 5 years prior to screening
Have had a blood transfusion or severe blood loss within 90 days prior to screening or have known hematological conditions that may interfere with HbA1c measurement
Treatment with GLP-1 RA or pramlintide, in a period of 3 months prior to Visit 1
Discontinuation of GLP-1 RA or pramlintide, due to intolerability any time prior to Visit 1
Are currently enrolled in any other clinical study involving an investigational product or any other type of medical research judged not to be scientifically or medically compatible with this study
Have participated within the last 30 days in a clinical trial involving an investigational product. If the previous investigational product has a long half-life, 3 months or 5 half-lives (whichever is longer) should have passed
Have previously completed or withdrawn from this study or randomized into any other study investigating tirzepatide

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Double

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Tirzepatide - Maximum Tolerated Dose (MTD) Participants received a starting dose of 2.5 milligrams (mg) tirzepatide administered as subcutaneous (SC) injection once weekly (QW) and escalated by 2.5 mg every 4 weeks to a maximum of 15 mg QW or MTD tolerated by the participant (5 mg QW or 10 mg QW) for up to 5 years.	Drug: Tirzepatide Administered SC Other Names: LY3298176
Experimental: 1.5 mg Dulaglutide Participants received 1.5 mg dulaglutide administered as SC injection QW for up to 5 years.	Drug: Dulaglutide Administered SC Other Names: LY2189265

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Number of Participants From Randomization to First Occurrence of Death From MACE-3 [Composite Endpoint of Major Adverse Cardiovascular Events Death From Cardiovascular Causes, Myocardial Infarction (MI) or Stroke] Time Frame: From randomization (week 0) up to week 259	Number of participants with first occurrence of Clinical Endpoint Committee (CEC), a composite endpoint i.e., from time of randomization to first occurrence of cardiovascular (CV) death, myocardial infarction and stroke combined data was reported. Time to event was defined as the number of days from the date of randomization to the first occurrence of any of these events during the study follow-up period. Participants without an event were censored at their last known contact or end of follow-up.	From randomization (week 0) up to week 259

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Number of Participants From Randomization to Time to Occurrence of All-Cause Death Time Frame: From randomization (week 0) up to week 259	The number of participants from randomization to time to occurrence of Clinical Endpoint Committee (CEC) confirmed all-cause death was reported. Time to event was defined as the number of days from the date of randomization to the first occurrence of all-cause death during the study follow-up period. Participants without an event were censored at their last known contact or end of follow-up.	From randomization (week 0) up to week 259
Number of Participants From Randomization to Time of Occurrence of CV Death Time Frame: From randomization (week 0) up to week 259	Number of participants from time of randomization to time to occurrence of CEC confirmed CV death was reported. Time to event was defined as the number of days from the date of randomization to the first occurrence of CV death during the study follow-up period. Participants without an event were censored at their last known contact or end of follow-up.	From randomization (week 0) up to week 259
Number of Participants From Randomization to Time to First Occurrence of Myocardial Infarction (MI) Time Frame: From randomization (week 0) up to week 259	The number of participants from randomization to first occurrence of CEC confirmed MI was reported. Time to event was defined as the number of days from the date of randomization to the first occurrence of nonfatal MI during the study follow-up period. Participants without an event were censored at their last known contact or end of follow-up.	From randomization (week 0) up to week 259
Number of Participants From Randomization toTime to First Occurrence of Stroke Time Frame: From randomization (week 0) up to week 259	The number of participants from randomization to first occurrence of CEC confirmed stroke was reported. Time to event was defined as the number of days from the date of randomization to the first occurrence of nonfatal stroke during the study follow-up period. Participants without an event were censored at their last known contact or end of follow-up.	From randomization (week 0) up to week 259
Number of Participants From Randomization to Time to First Occurrence of the Expanded Composite of CV Death, MI, Stroke or Coronary Revascularization (MACE-4) Time Frame: From randomization (week 0) up to week 259	The number of participants from randomization to first occurrence of MACE-4 was reported. Time to event was defined as the number of days from the date of randomization to the first occurrence of any of these events during the study follow-up period. Participants without an event were censored at their last known contact or end of follow-up.	From randomization (week 0) up to week 259
Number of Participants From Randomization to Time to First Occurrence of CV Deaths or Heart Failure Events Requiring Hospitalization and/or Urgent Heart Failure Visits Time Frame: From randomization (week 0) up to week 259	The number of participants from randomization to first occurrence of Clinical Endpoint Committee (CEC) confirmed heart failure requiring hospitalisation or urgent heart failure was reported. Time to event was defined as the number of days from the date of randomization to the first occurrence of any of these events during the study follow-up period. Participants without an event were censored at their last known contact or end of follow-up.	From randomization (week 0) up to week 259
Number of Participants From Randomization to Time to First Occurrence of Revascularization Time Frame: From randomization (week 0) up to week 259	The number of participants from randomization to first occurrence of coronary revascularization was reported. Time to event was defined as the number of days from the date of randomization to the first occurrence of revascularization during the study follow-up period. Participants without an event were censored at their last known contact or end of follow-up.	From randomization (week 0) up to week 259
Number of Participants From Randomization to Time to First Occurrence of New or Worsening Nephropathy Time Frame: From randomization (week 0) up to week 259	New or worsening nephropathy (Composite Endpoint 1) was defined as the first occurrence of any of the following events: persistent macroalbuminuria (urine albumin-to-creatinine ratio >300 mg/g), persistent doubling of serum creatinine with eGFR <45 mL/min/1.73 m², onset of end-stage renal disease (including initiation of chronic dialysis or kidney transplantation), or death due to renal disease. Time to event was defined as the number of days from the date of randomization to the first occurrence any of these events. during the study follow-up period. Participants without an event were censored at their last known contact or end of follow-up.	From randomization (week 0) up to week 259
Change From Baseline to 36 Months in Estimated Glomerular Filtration Rate (eGFR) in Patients With High or Very-high Risk Chronic Kidney Disease (CKD) Time Frame: Baseline, 36 Months	Change from baseline in eGFR calculated as difference between value at 36 months and baseline value. Participants included in this analysis were classified as having high or very high risk of chronic kidney disease at baseline based on their kidney function (eGFR) and urine albumin-to-creatinine ratio (UACR). High risk included participants with eGFR 45 to less than 60 milliliters/minutes/1.73 square metres (mL/min/1.73 m²) and UACR greater than 30 mg/g, or eGFR 60 mL/min/1.73 m² or higher with UACR greater than 300 mg/g. Very high risk included participants with eGFR less than 45 mL/min/1.73 m² or severely increased UACR (greater than 300 mg/g). These criteria are associated with an increased risk of worsening kidney function. Least squares (LS) mean was calculated using analysis of covariance (ANCOVA) model for endpoint measures: Variable = Baseline + Treatment + Analysis Country + Baseline sodium-glucose cotransporter-2 (SGLT-2) Use Flag.	Baseline, 36 Months
Change From Baseline to 36 Months in Hemoglobin A1c (HbA1c) Time Frame: Baseline, 36 Months	HbA1c is the glycosylated fraction of hemoglobin A. HbA1c is measured primarily to identify average plasma glucose concentration over prolonged periods of time. Change in HbA1c from baseline up to 36 months during in-trial period were reported. In-trial observation period was defined as the period from date of randomization to the first of (both inclusive): date of follow-up visit, date when participant withdrew consent, date of last contact with participant (for participant lost to follow-up), and date of death. LS mean was calculated using ANCOVA model for endpoint measures: Variable = Baseline + Treatment + Analysis Country + Baseline SGLT-2i Use Flag (Type III sum of squares).	Baseline, 36 Months
Percent Change From Baseline to 36 Months in Body Weight Time Frame: Baseline, 36 Months	LS mean was calculated using ANCOVA model for endpoint measures: Variable = Baseline + Treatment + Analysis Country + Baseline SGLT-2i Use Flag (Type III sum of squares)	Baseline, 36 Months
Percent Change From Baseline to 36 Months in Urinary Albumin to Creatinine Ratio (UACR) Time Frame: Baseline, 36 Months	Urine samples were collected for the analysis of UACR. UACR (gram per kilograms [g/kg]) was calculated as urine albumin (gram per liter [g/L])/urine creatinine (kg/L). Percent change from baseline at 36 months was calculated as: [(UACR at 36 months - baseline UACR) / baseline UACR] × 100. LS mean was calculated using ANCOVA model for endpoint measures: log(Actual Measurement/Baseline) = log(Baseline) + Treatment + Analysis Country + Baseline SGLT-2i Use Flag (Type III sum of squares).	Baseline, 36 Months
Percent Change From Baseline to 24 Months in Blood Lipids (Total Cholesterol (TC), Low-Density Lipoprotein Cholesterol (LDL-C), High-Density Lipoprotein Cholesterol (HDL-C), and Triglycerides (TG)) Time Frame: Baseline, 24 Months	Blood samples of participants who had fasted for 12 to 14 hours were collected for lipid profile (TC, LDL-C, HDL-C, TG) assessment. The lipid profile asesses the risk of heart disease. Percent change from baseline = 100*(post-baseline assessment - baseline assessment)/baseline assessment. LS mean was calculated using ANCOVA model for endpoint measures: log(Actual Measurement/Baseline) = log(Baseline) + Treatment + Analysis Country + Baseline SGLT-2i Use Flag.	Baseline, 24 Months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Eli Lilly and Company

Investigators

Study Director: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST), Eli Lilly and Company

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

A Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

May 29, 2020

Primary Completion (Actual)

June 12, 2025

Study Completion (Actual)

June 12, 2025

Study Registration Dates

First Submitted

February 3, 2020

First Submitted That Met QC Criteria

February 3, 2020

First Posted (Actual)

February 5, 2020

Study Record Updates

Last Update Posted (Actual)

July 8, 2026

Last Update Submitted That Met QC Criteria

June 11, 2026

Last Verified

June 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

17073
I8F-MC-GPGN (Other Identifier: Eli Lilly and Company)
2019-002735-28 (EudraCT Number)
2023-507846-96-00 (Ctis)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.

IPD Sharing Time Frame

Data are available 6 months after the primary publication and approval of the indication studied in the US and EU, whichever is later. Data will be indefinitely available for requesting.

IPD Sharing Access Criteria

A research proposal must be approved by an independent review panel and researchers must sign a data sharing agreement.

IPD Sharing Supporting Information Type

STUDY_PROTOCOL
SAP
CSR

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

A Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes (SURPASS-CVOT)

The Effect of Tirzepatide Versus Dulaglutide on Major Adverse Cardiovascular Events in Patients With Type 2 Diabetes (SURPASS-CVOT)

Study Overview

Status

Conditions

Intervention / Treatment

Study Type

Enrollment (Actual)

Phase

Contacts and Locations

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Secondary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Collaborators and Investigators

Sponsor

Investigators

Publications and helpful links

General Publications

Helpful Links

Study record dates

Study Major Dates

Study Start (Actual)

Primary Completion (Actual)

Study Completion (Actual)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Actual)

Study Record Updates

Last Update Posted (Actual)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

IPD Plan Description

IPD Sharing Time Frame

IPD Sharing Access Criteria

IPD Sharing Supporting Information Type

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product