The Learning Effects of Task-priority Strategy on Dual-task Weight Shifting and Brain Plasticity in Patients With Parkinson's Disease

(1) postural and suprapostural performance of a dual task would be differently affected by the strategy of task prioritization and (2) the cortical activation is different according to attentional focus strategies.

Study Overview

• Status: Completed
• Conditions: Postural and Suprapostural Performance During Dual Tasking in Patients With Parkinson's Disease
• Intervention / Treatment: Behavioral: Weight-shifting training

Detailed Description

These hypothesis would be tested by gait performance, suprapostural accuracy and relative power spectrum of EEG.

• Study Type: Interventional
• Enrollment (Actual): 28
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Taiwan
  • Taipei, Taiwan
    • National Taiwan University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 50 years to 85 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• 1. modified H-Y stage II-III Parkinson's disease 2. No other diseases 3. Non-demented PD 4. Non-tremor PD

Exclusion Criteria:

• None

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Postural; During training, participants in this group are instructed to focus on their posture during weight-shifting.	Behavioral: Weight-shifting training; Postural task: Participants are standing with their weak side on the force plate. During the task, they wight-shift from side to side ranging from 10 to 90 percent of their body weight. Suprapostural task: Participants hold a tray with their arms beside the body, 90 degrees of elbow flexion. They rotate the tray left and right for 45 degrees respectively. During their task, participants should weight-shift and rotate the tray at the same time.
Experimental: Suprapostural; During training, participants in this group are instructed to focus on their suprapostural task during weight-shifting.	Behavioral: Weight-shifting training; Postural task: Participants are standing with their weak side on the force plate. During the task, they wight-shift from side to side ranging from 10 to 90 percent of their body weight. Suprapostural task: Participants hold a tray with their arms beside the body, 90 degrees of elbow flexion. They rotate the tray left and right for 45 degrees respectively. During their task, participants should weight-shift and rotate the tray at the same time.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
EEG relative power in the delta band	postural and suprapostural performance of a dual task	60 minutes
EEG relative power in the theta band	postural and suprapostural performance of a dual task	60 minutes
EEG relative power in the alpha band	postural and suprapostural performance of a dual task	60 minutes
EEG relative power in the beta band	postural and suprapostural performance of a dual task	60 minutes
EEG relative power in the gamma band	postural and suprapostural performance of a dual task	60 minutes
COP trajectory recorded from the force plate	performance of the postural task	60 minutes
Angles from inclinometer	performance of the suprapostural task	60 minutes

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Gait velocity from GAITRite	gait performance	5 minutes
Cadence from GAITRite	gait performance	5 minutes
Mean step length from GAITRite	gait performance	5 minutes
Step-to-step variability from GAITRite	gait performance	5 minutes

Collaborators and Investigators

• Sponsor: National Taiwan University Hospital

Study record dates

Study Major Dates

• Study Start (Actual): February 25, 2020
• Primary Completion (Actual): June 22, 2020
• Study Completion (Actual): June 22, 2020

Study Registration Dates

• First Submitted: February 24, 2020
• First Submitted That Met QC Criteria: February 26, 2020
• First Posted (Actual): February 27, 2020

Study Record Updates

• Last Update Posted (Actual): March 17, 2021
• Last Update Submitted That Met QC Criteria: March 16, 2021
• Last Verified: February 1, 2020

More Information

Terms related to this study

• Keywords: Parkinson; attention; dual-task training; electroencephalogram (EEG)
• Additional Relevant MeSH Terms: Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Parkinsonian Disorders; Basal Ganglia Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Parkinson Disease
• Other Study ID Numbers: 201907085RIND

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No