Study to Evaluate the Efficacy (Effect on Disease) and Safety of Finerenone in Participants With Heart Failure and Left Ventricular Ejection Fraction (Proportion of Blood Expelled Per Heart Stroke) Greater or Equal to 40% (FINEARTS-HF)

August 25, 2025 updated by: Bayer

A Multicenter, Randomized, Double-blind, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Finerenone on Morbidity and Mortality in Participants With Heart Failure (NYHA II-IV) and Left Ventricular Ejection Fraction ≥ 40% (LVEF ≥ 40%)

The purpose of this study is to evaluate the effect of finerenone compared to placebo (a tablet without active substance) in the reduction of cardiovascular death (generally meaning death due to disease of the heart or blood vessels) and total Heart Failure (HF) events, including HF hospitalization and urgent visits for HF(generally meaning a hospital stay or urgent presentation to a healthcare unit due to worsening symptoms of heart failure) in patients suffering from HF with an ejection fraction greater than or equal to 40%. Researchers will also collect information on how much the heart disease has impact on patient's lives, change of kidney function, and how well finerenone treatment is tolerated. The study plans to enroll 6000 male and female patients of the age of 40 years and above suffering from heart failure with ejection fraction greater than or equal to 40%. Participants will take the study product as oral tablet with a dose between 0 (Placebo) 40 mg once daily. Study duration will be up to 43 months.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

6016

Phase

  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Argentina
      • Buenos Aires, Argentina, C1056ABH
        • Investigaciones Medicas IMOBA S.R.L.
      • Corrientes, Argentina, 3400
        • Instituto de Cardiologia de Corrientes Juana F. Cabral | Corrientes, Argentina
      • Córdoba, Argentina, 5000
        • Clinica Privada del Prado
      • Córdoba, Argentina, 5003
        • Instituto Médico DAMIC- Fundación Rusculleda
      • Santa Fe, Argentina, S3000FWO
        • Centro de Investigaciones Clinicas del Litoral | Santa Fe, Argentina
    • Buenos Aires
      • Ciudad Autónoma de Buenos Aire, Buenos Aires, Argentina, C1056ABI
        • Centro de Investigaciones Metabolicas | Ciudad de Autonoma de Buenos Aires, Argentina
      • Coronel Suárez, Buenos Aires, Argentina, B7540GHD
        • Clinica Coronel Suárez
      • La Plata, Buenos Aires, Argentina, B1900
        • Hospital Italiano de La Plata | Clinical Research Department
      • Lanús, Buenos Aires, Argentina, B1824
        • Centro de Investigaciones Medicas Lanus | Buenos Aires, Argentina
      • Quilmes, Buenos Aires, Argentina, 1878
        • Sanatorio Modelo Quilmes
      • San Martín, Buenos Aires, Argentina, 1650
        • Corporación Médica de General San Martín
      • Zárate, Buenos Aires, Argentina, B2800DGH
        • Instituto De Investigaciones Clinicas Zarate | Zarate, Argentina
    • Buenos Aires F.D.
      • Buenos Aires, Buenos Aires F.D., Argentina, C1428ART
        • Instituto Cardiovascular de Buenos Aires | Buenos Aires, Argentina
    • Ciudad Auton. de Buenos Aires
      • Buenos Aires, Ciudad Auton. de Buenos Aires, Argentina, 1426
        • Hospital Militar Central "CIR. MY. C. Argerich"
      • Buenos Aires, Ciudad Auton. de Buenos Aires, Argentina, C1440CFD
        • Centro de Especialidades Medicas (CEMEDIC)
      • CABA, Ciudad Auton. de Buenos Aires, Argentina, C1018DES
        • CEDIC Centro de Investigación Clínica | Buenos Aires, Argentina
    • Santa Fe Province
      • Rosario, Santa Fe Province, Argentina, 2000
        • Grupo Orono | Instituto Cardiovascular de Rosario - Insuficiencia Cardiaca y Trasplante Department
      • Rosario, Santa Fe Province, Argentina, S2000DEJ
        • Consultorios Integrados Rosario | Instituto Medico de la Fundacion de Estudios Clinicos
    • Tucumán Province
      • San Miguel de Tucumán, Tucumán Province, Argentina, 4000
        • Instituto de Cardiologia | Tucuman, AR
  • Australia
    • New South Wales
      • Camperdown, New South Wales, Australia, 2050
        • Royal Prince Alfred Hospital
      • Gosford, New South Wales, Australia, 2250
        • Gosford Hospital
      • New Lambton Heights, New South Wales, Australia, 2305
        • John Hunter Hospital
    • Queensland
      • Auchenflower, Queensland, Australia, 4066
        • The Wesley Hospital
      • Chermside, Queensland, Australia, 4032
        • The Prince Charles Hospital
      • Herston, Queensland, Australia, 4029
        • Royal Brisbane and Women's Hospital
      • Southport, Queensland, Australia, 4215
        • Gold Coast University Hospital
    • South Australia
      • Bedford Park, South Australia, Australia, 5042
        • Flinders Medical Centre
      • Leabrook, South Australia, Australia, 5068
        • Advara HeartCare Leabrook
    • Victoria
      • Bundoora, Victoria, Australia, 3083
        • Advara HeartCare Ringwood
  • Austria
      • Salzburg, Austria, 5020
        • Uniklinikum Salzburg - Landeskrankenhaus
      • Vienna, Austria, 1090
        • Universitätsklinikum AKH Wien
      • Vienna, Austria, 1190
        • Imed19-privat
      • Vienna, Austria, 1210
        • Klinik Floridsdorf - Krankenhaus Nord
    • Carinthia
      • Klagenfurt, Carinthia, Austria, 9020
        • Klinikum Klagenfurt am Wörthersee
    • Lower Austria
      • Sankt Pölten, Lower Austria, Austria, 3100
        • Universitätsklinikum St. Pölten
    • Styria
      • Graz, Styria, Austria, 8036
        • Medizinische Universität Graz
    • Upper Austria
      • Braunau am Inn, Upper Austria, Austria, 5280
        • Krankenhaus St. Josef Braunau | Innere Medizin I
    • Vorarlberg
      • Feldkirch, Vorarlberg, Austria, 6807
        • Landeskrankenhaus Feldkirch
  • Brazil
      • Minas Gerais, Brazil, 38400-368
        • Eurolatino Pesquisas Medicas | Uberlandia, MG
    • Estado de Bahia
      • Salvador, Estado de Bahia, Brazil, 50040-410
        • Santa Casa de Misericórdia da Bahia
    • Federal District
      • Brasília, Federal District, Brazil, 70390-700
        • Hospital do Coracao do Brasil
    • Goiás
      • Goiânia, Goiás, Brazil, 74605-020
        • Hospital das Clinicas da Universidade Federal de Goias | Centro de Pesquisa em Cardiologia
    • Paraná
      • Curitiba, Paraná, Brazil, 80045-170
        • Quanta Diagnostico Por Imagem | Research and Innovation Department
      • Paraná, Paraná, Brazil, 83430-000
        • Sociedade Hospitalar Angelina Caron | Departamento de Ensino e Pesquisa
    • Rio Grande do Sul
      • Caxias do Sul, Rio Grande do Sul, Brazil, 95070-560
        • Fundacao Universidade de Caxias Do Sul
      • Porto Alegre, Rio Grande do Sul, Brazil, 90035-903
        • Hospital de Clinicas de Porto Alegre | Clinical Research Center - Surgery Research Center
      • Porto Alegre, Rio Grande do Sul, Brazil, 90850-170
        • Hospital Mae de Deus
      • Porto Alegre, Rio Grande do Sul, Brazil, 91350-280
        • FZ Pesquisa e Servicos em Cardiologia | Porto Alegre, Brazil
    • Santa Catarina
      • Blumenau, Santa Catarina, Brazil, 89020-430
        • MK Consultoria Médico Científica Ltda/Angiocor Blumenau
    • Sergipe
      • Aracaju, Sergipe, Brazil, 49055-530
        • Centro de Pesquisa Clinica do Coração | Aracaju, Brasil
    • São Paulo
      • Belo Horizonte, São Paulo, Brazil, 30110-130
        • Hospital Felicio Rocho
      • Campinas, São Paulo, Brazil, 13060-080
        • Campinas Clinical Research Institute (IPECC) | Campinas, Brazil
      • Marília, São Paulo, Brazil, 17515-000
        • Instituto do Coração de Marilia | Marilia, Brasil
      • Ribeirão Preto, São Paulo, Brazil, 14026-020
        • Centro Avançado de Pesquisa para Diagnóstico - CAPED
      • São Paulo, São Paulo, Brazil, 13034-685
        • Hospital PUC-Campinas | Centro de Pesquisa Clínica Sao Lucas
      • Tatuí, São Paulo, Brazil, 18270-170
        • IMC - Instituto de Moléstias Cardiovasculares Tatuí
      • Votuporanga, São Paulo, Brazil, 15500-003
        • Santa Casa de Misericórdia de Votuporanga
  • Bulgaria
      • Burgas, Bulgaria, 8000
        • Ambulatory facility for specialized outpatient medical care
      • Haskovo, Bulgaria, 6304
        • MHAT Haskovo
      • Pazardzhik, Bulgaria, 4400
        • MHAT Zdrave
      • Pernik, Bulgaria, 2300
        • Multiprofile Hospital for Active Treatment Sveti Georgi OOD, Pernik - Department of Cardiology
      • Pleven, Bulgaria, 5800
        • Medical Center Medconsult Pleven
      • Plovdiv, Bulgaria, 4000
        • Medical centre Hipokrat - N EOOD
      • Plovdiv, Bulgaria, 4004
        • Multiprofile Hospital for Active Treatment Sveta Karidad | Cardiology Department
      • Plovdiv, Bulgaria, 4000
        • Multiprofile Hospital for Active Treatment Medline | Cardiology Department
      • Shumen, Bulgaria, 9700
        • Multiprofile Hospital for Active Treatment | Shumen - First Department of Internal Medicine
      • Sliven, Bulgaria, 8800
        • MHAT Hadzhi Dimitar
      • Sofia, Bulgaria, 1233
        • NMTH Tzar Boris III
      • Sofia, Bulgaria, 1527
        • UMHAT Tsaritsa Joanna-ISUL EAD Sofia
      • Sofia, Bulgaria, 1202
        • Second Medical Center Sofia EOOD
      • Sofia, Bulgaria, 1510
        • Medical Center Hera
      • Sofia, Bulgaria, 1233
        • Multiprofile Hospital for Active Treatment Knyaginya Klementina Sofia EAD | Cardiology Department
      • Sofia, Bulgaria, 1309
        • Multiprofile Hospital for Active Treatment 'National Cardiology Hospital' EAD, Sofia
      • Sofia, Bulgaria, 1404
        • Multiprofile Hospital for Active Treatment Sveta Sofia | Internal Diseases Department
      • Stara Zagora, Bulgaria, 6000
        • MHAT Trakia
      • Veliko Tarnovo, Bulgaria, 5000
        • Multiprofile Hospital for Active Treatment Dr. Stefan Cherkezov | Cardiology Department
      • Yambol, Bulgaria, 8600
        • Multiprofile Hospital for Active Treatment Sveti Panteleymon Yambol | Cardiology Department
  • Canada
    • British Columbia
      • New Westminster, British Columbia, Canada, V3L 3W4
        • Fraser Clinical Trials, Inc.
    • Manitoba
      • Winnipeg, Manitoba, Canada, R2H 2A6
        • St. Boniface Hospital
    • New Brunswick
      • Moncton, New Brunswick, Canada, E1G 1A7
        • G.A. Research Associates, Ltd.
    • Nova Scotia
      • Halifax, Nova Scotia, Canada, B3H 3A7
        • Dalhousie University - Queen Elizabeth II (QEII) Health Sciences Centre - Halifax Infirmary (HI)
    • Ontario
      • Brampton, Ontario, Canada, L6Z 4N5
        • Brampton Clinical Trials
      • Cambridge, Ontario, Canada, N1R 6V6
        • Cambridge Cardiac Care Centre
      • Cambridge, Ontario, Canada, N1R 7R1
        • Vizel Cardiac Research
      • London, Ontario, Canada, N6A 5A5
        • London Health Sciences Centre (LHSC) - University Hospital
      • Mississauga, Ontario, Canada, L5K 2L3
        • KMH Cardiology Clinics Inc.
      • North York, Ontario, Canada, M6B 3H7
        • North York Diagnostic and Cardiac Centre
      • Oakville, Ontario, Canada, L6K 3W7
        • Oakville Cardiovascular Research
      • Oshawa, Ontario, Canada, L1J 2K1
        • Office of Dr. James Cha, MD
      • Peterborough, Ontario, Canada, K9J 0B2
        • Kawartha Cardiology Clinical Trials
      • Scarborough Village, Ontario, Canada, M1B 5N1
        • Corcare
      • Toronto, Ontario, Canada, M5G 1X5
        • Mount Sinai Hospital
      • Toronto, Ontario, Canada, M5S 1B2
        • Women's College Hospital
      • Toronto, Ontario, Canada, M4P 1E4
        • Medicus MFC Inc.
    • Quebec
      • Laval, Quebec, Canada, H7M 3L9
        • Centre intégré de santé et de services sociaux de Laval, Hôp
      • Montreal, Quebec, Canada, H1T 3Y7
        • Clinique Sante Cardio MC
      • Montreal, Quebec, Canada, H2X 0C1
        • Centre Hospitalier de l'Université de Montréal-CHUM
      • Montreal, Quebec, Canada, H4A 3J1
        • Montreal General Hospital
  • China
      • Beijing, China, 100029
        • Beijing Anzhen Hospital, Capital Medical University
      • Beijing, China, 102218
        • Beijing Tsinghua Changgung Hospital
      • Beijing, China, 100050
        • Beijing Friendship Hospital, Capital Medical University
      • Shanghai, China, 200065
        • Shanghai Tongji Hospital of Tongji University
      • Shanghai, China, 200100
        • Shanghai East Hospital Affiated to Tongji University
      • Tianjin, China, 300000
        • Tianjin People's Hospital
    • Fujian
      • Fuzhou, Fujian, China, 350001
        • Fujian Provincial Hospital
    • Gansu
      • Lanzhou, Gansu, China, 730030
        • Lanzhou University Second Hospital
    • Guangdong
      • Guangzhou, Guangdong, China, 510080
        • The First Affiliated Hospital of Sun Yat-sen University
      • Guangzhou, Guangdong, China, 510515
        • Nanfang Hospital, Southern Medical University
      • Guangzhou, Guangdong, China, 510120
        • Sun Yat-Sen Memorial Hosp. Sun Yat-Sen Univ.
      • Guangzhou, Guangdong, China, 510405
        • The First Affiliated Hospital of Guangzhou University of TCM
      • Guangzhou, Guangdong, China, 510630
        • The First Affiliated Hospital of Jinan University
      • Guangzhou, Guangdong, China, 510000
        • Guangdong Provincial People's Hospital
    • Guizhou
      • Guiyang, Guizhou, China, 550002
        • Guizhou Provincial People's Hospital
    • Hainan
      • Haikou, Hainan, China, 570311
        • Hainan Provincial People's Hospital
      • Sanya, Hainan, China, 572000
        • Hainan Third People's Hospital (Province Nongken Sanya Hopt)
    • Hebei
      • Shijiazhuang, Hebei, China, 050000
        • The First Hospital of Hebei Medical Univesity
    • Heilongjiang
      • Daqing, Heilongjiang, China, 163311
        • Daqing Oilfield General Hospital
    • Henan
      • Xinxiang, Henan, China, 453000
        • Xinxiang Central Hospital
    • Hunan
      • Changsha, Hunan, China, 410004
        • Changsha Central Hospital
      • Changsha, Hunan, China, 410000
        • The Third Xiangya Hospital of Central South University
      • Changsha, Hunan, China, 410005
        • Hunan Provincial People's Hospital
    • Jiangsu
      • Huai'an, Jiangsu, China, 223300
        • Huai'an First People's Hospital, Nanjing Medical University
      • Lianyungang, Jiangsu, China, 222002
        • The First People's Hospital of Lianyungang
      • Nanjing, Jiangsu, China, 210008
        • NJ Drum Tower Hospital, the Affil Hos of NJ Univ Med School
      • Nanjing, Jiangsu, China, 210029
        • Jiangsu Province Hospital
      • Nanjing, Jiangsu, China, 210009
        • Zhongda Hospital Southeast University
      • Nanjing, Jiangsu, China, 210000
        • The Second Affiliated Hospital of Nanjing Medical University
      • Nanjing, Jiangsu, China, 211103
        • Nanjing Jiangning Hospital
      • Suzhou, Jiangsu, China, 215000
        • 1st Affiliated hospital of Soochow University
    • Jilin
      • Changchun, Jilin, China, 130021
        • Jilin Province People's Hospital
      • Changchun, Jilin, China, 130061
        • The First Hospital of Jilin University
    • Liaoning
      • Panjin, Liaoning, China, 124010
        • Panjin Liaohe Oilfield GEM Flower Hospital
    • Ningxia
      • Yinchuan, Ningxia, China, 750004
        • General Hospital of Ningxia Medical University
      • Yinchuan, Ningxia, China, 750001
        • Yinchuan No.1 People's Hospital
    • Shaanxi
      • Xi'an, Shaanxi, China, 710068
        • Shaanxi Provincial People's Hospital
    • Shaanxi Sheng
      • Xi'an, Shaanxi Sheng, China, 710061
        • The First Affiliated Hospital of Xi'an Jiaotong University
    • Shandong
      • Jinan, Shandong, China, 250013
        • Jinan Central Hospital
    • Shanxi
      • Taiyuan, Shanxi, China, 030012
        • Shanxi Provincial People's Hospital
    • Sichuan
      • Chengdu, Sichuan, China, 610072
        • SichuanAcademyofMedicalSciences&SichuanProvincialPeople'sHos
      • Chengdu, Sichuan, China, 610041
        • West China Hospital Sichuan University
    • Xinjiang
      • Ürümqi, Xinjiang, China, 830001
        • People's Hospital of Xinjiang Uygur Autonomous Region
      • Ürümqi, Xinjiang, China, 830011
        • The First Affiliated Hospital of Xinjiang Medical University
    • Zhejiang
      • Hangzhou, Zhejiang, China, 310003
        • 1st Affiliated Hospital of College Medicine, Zhejiang Univ.
  • Colombia
      • Barranquilla, Colombia, 080001
        • Fundacio del Caribe para la Investigacio Bio-Medica (BIOS)
      • Bogotá, Colombia, 110131
        • Fundacion Cardioinfantil
      • Bogotá, Colombia, 110231
        • Hospital Universitario de San Ignacio
      • Bogotá, Colombia, 110621
        • Hospital Universitario Clinica San Rafael
      • Medellín, Colombia, 050010
        • Hospital San Vicente Fundación
      • Medellín, Colombia, 050034
        • Clinica Cardio VID
    • Antioquia
      • Medellín, Antioquia, Colombia, 050010
        • Hospital Alma Mater de Antioquia
      • Medellín, Antioquia, Colombia, 050015
        • Hospital General de Medellin
      • Medellín, Antioquia, Colombia, 050021
        • Rodrigo Botero S.A.S
      • Rionegro, Antioquia, Colombia, 054040
        • Sociedad Médica Rionegro SOMER S.A.
    • Atlántico
      • Baranquilla, Atlántico, Colombia, 080020
        • Clínica de la Costa SAS
      • Barranquilla, Atlántico, Colombia, 080020
        • IPS Centro Científico Asistencial S.A.S
      • Barranquilla, Atlántico, Colombia, 080020
        • Corazon IPS S.A.S.
    • Bogota D.C.
      • Bogotá, Bogota D.C., Colombia, 111061
        • Caja de Compensación Familiar CAFAM
      • Bogotá, Bogota D.C., Colombia, 111411
        • Hospital Universitario Mayor-Méderi
    • Quindío Department
      • Armenia, Quindío Department, Colombia, 630004
        • Cardiomet Cequin Sas
    • Santander Department
      • Bucaramanga, Santander Department, Colombia, 680002
        • Instituto del Corazón de Bucaramanga
    • Tolima Department
      • Ibagué, Tolima Department, Colombia, 730008
        • Mediservis del Tolima IPS S.A.S
    • Valle del Cauca Department
      • Santiago de Cali, Valle del Cauca Department, Colombia, 760042
        • Clinica IMBANACO S.A.S
  • Czechia
      • Brno, Czechia, 612 00
        • Kardiologicka ambulance Brno s.r.o.
      • Brno, Czechia, 602 00
        • Kardiologie MUDr. Libor Nechvátal s.r.o.
      • Chlumec nad Cidlinou, Czechia, 503 51
        • Kardio Chlumec s.r.o.- Kardiologicka ambulance
      • Dolní Břežany, Czechia, 252 41
        • Poliklinika Dolní Brežany
      • Hradec Králové, Czechia, 500 05
        • Fakultni nemocnice Hradec Kralove
      • Kroměříž, Czechia, 767 01
        • Kromerizska nemocnice a.s.
      • Kroměříž, Czechia, 767 01
        • LUNACOR, Centrum pro choroby srdce a cev
      • Liberec, Czechia, 460 63
        • Krajská nemocnice Liberec
      • Louny, Czechia, 440 01
        • KardioBusak s.r.o.
      • Pilsen, Czechia, 301 00
        • Fakultni nemocnice Plzen
      • Poděbrady, Czechia, 290 01
        • Polabska zdravotni, s.r.o.
      • Prague, Czechia, 140 21
        • Institut klinicke a experimentalni mediciny
      • Prague, Czechia, 150 06
        • Fakultni nemocnice v Motole
      • Prague, Czechia, 12808
        • Všeobecná fakultní nemocnice v Praze - II. interní klinika - klinika kardiologie a angiologie
      • Prague, Czechia, 169 02
        • Ustredni vojenska nemocnice Praha
      • Praha 11 - Chodov, Czechia, 148 00
        • Affidea Praha s.r.o - Kardiologie
      • Písek, Czechia, 39701
        • Kardiologická a interní ambulance
      • Třebíč, Czechia, 67401
        • Kardio s.r.o.
      • Třinec, Czechia, 73961
        • Nemocnice Podlesi
      • Zlín, Czechia, 760 01
        • Angiocor s.r.o.
      • Znojmo, Czechia, 669 02
        • Nemocnice Znojmo
      • Český Krumlov, Czechia, 381 01
        • Kardiologicka ambulance
    • South Moravian
      • Brno, South Moravian, Czechia, 625 00
        • Fakultní nemocnice Brno - Interní kardiologická klinika
  • Denmark
      • Esbjerg, Denmark, 6700
        • Sydvestjysk Sygehus Esbjerg | Kardiologisk Forskningsenhed
      • Hellerup, Denmark, 2900
        • Capital Region | Gentofte Hospital - Cardiology Research
      • Herlev, Denmark, 2730
        • Capital Region | Herlev Hospital - Heart Disease Department
      • Herning, Denmark, 7400
        • Region Midtjylland | Regionshospitalet Godstrup - Clinic for Heart Research
      • Holbæk, Denmark, 4300
        • Region Sjælland | Holbaek Sygehus - Cardiology department
      • Hvidovre, Denmark, 2650
        • Hvidovre Hospital - Hjertesygdomme
      • Randers, Denmark, 8930
        • Regionshospitalet Randers - Medicinsk afdeling
      • Svendborg, Denmark, 5700
        • Odense University Hospital | Svendborg Hospital - Cardiovascular Research Unit
      • Århus N, Denmark, 8200
        • Aarhus Universitetshospital - Børn og Unge
  • Finland
      • Espoo, Finland, 2740
        • HUS Jorvin sairaala
      • Tampere, Finland, 33520
        • Tampereen yliopistollinen sairaala
      • Turku, Finland, 20520
        • Turun yliopistollinen keskussairaala
  • Germany
      • Hamburg, Germany, 20246
        • Universitätsklinikum Hamburg Eppendorf (UKE)
    • Baden-Wurttemberg
      • Ulm, Baden-Wurttemberg, Germany, 89077
        • Herzklinik Ulm GbR
    • Bavaria
      • Würzburg, Bavaria, Germany, 97080
        • Klinikum der Universität Würzburg
    • Lower Saxony
      • Hanover, Lower Saxony, Germany, 30625
        • Medizinische Hochschule Hannover (MHH)
    • North Rhine-Westphalia
      • Bielefeld, North Rhine-Westphalia, Germany, 33604
        • Städt. Kliniken Bielefeld gGmbH
      • Remscheid, North Rhine-Westphalia, Germany, 42859
        • Sana-Klinikum Remscheid GmbH
      • Witten, North Rhine-Westphalia, Germany, 58455
        • Forschungszentrum Ruhr | KliFoCenter GmbH
  • Greece
      • Alexandroupoli, Greece, 68100
        • University General Hospital of Alexandroupoli
      • Ampelokipi - Athens, Greece, 11526
        • General Hosp of Athens "Korgialenio-Benakeio" RCH
      • Athens, Greece, 11527
        • G. GENNIMATAS General State Hospital of Athens
      • Athens, Greece, 11528
        • Alexandra General Hospital of Athens
      • Athens, Greece, 115 27
        • Hippokration General Hospital of Athens
      • Chaïdári, Greece, 12462
        • University General Hospital of Athens "Attikon"
      • Heraklion, Greece, 711 10
        • University General Hospital of Heraklion - Department of Paediatrics
      • Larissa, Greece, 41110
        • University General Hospital of Larissa
      • Nea Ionia, Greece, 14233
        • Konstantopoulio General Hospital of Nea Ionia - AGIA OLGA
      • Pátrai, Greece, 26504
        • University General Hospital of Patras
      • Thessaloniki, Greece, 54642
        • Hippokration General Hospital of Thessaloniki - 3rd Department of Paediatrics, Nephrology Unit'
    • Attica
      • Kifissia, Attica, Greece, 14561
        • KAT General Hospital of Athens
  • Hong Kong
      • Hong Kong, Hong Kong
        • Queen Elizabeth Hospital Hong Kong
      • Hong Kong, Hong Kong, MISSING
        • Queen Mary Hospital
      • Hong Kong, Hong Kong, MISSING
        • Princess Margaret Hospital
    • N.T
      • Hong Kong, N.T, Hong Kong, MISSING
        • Prince of Wales Hospital
  • Hungary
      • Balatonfüred, Hungary, 8230
        • Cardiomobile Egeszsegugyi Szolgaltato Kft.
      • Budapest, Hungary, 1023
        • Budai Irgalmasrendi Kórház
      • Budapest, Hungary, 1083
        • University of Semmelweis/ Semmelweis Egyetem
      • Budapest, Hungary, 1134
        • Észak-Pesti Centrumkórház-Honvédkórház
      • Budapest, Hungary, 1145
        • Budapesti Uzsoki Utcai Kórház
      • Budapest, Hungary, 1024
        • Budapesti Jahn Ferenc Del-pesti Korhaz es Rendelointezet
      • Gyöngyös, Hungary, 3200
        • Bugat Pal Korhaz
      • Gyöngyös, Hungary, 3200
        • Pharma4Trial Kft.
      • Hódmezővásárhely, Hungary, 6800
        • Csongrad-Csanad Varmegyei Egeszsegugyi Ellato Kozpont Hodmezovasarhelyi Tagintezmeny
      • Miskolc, Hungary, 3526
        • Borsod-Abauj-Zemplen Varmegyei Korhaz es Egyetemi Oktatokorhaz
      • Nagykanizsa, Hungary, 8800
        • Nagykanizsai Kanizsai Dorottya Korhaz
      • Nyíregyháza, Hungary, 4400
        • Medifarma-98 Egeszsegugyi, Kereskedelmi es Szolgaltato Kft.
      • Pécs, Hungary, 7635
        • Da Vinci Magánklinika
      • Pécs, Hungary, 7623
        • Coromed Smo Kft
      • Szeged, Hungary, 6720
        • SZTE ÁOK Szent Györgyi Albert Klinikai Kozpont
      • Szekszárd, Hungary, 7100
        • Tolna Varmegyei Balassa Janos Korhaz
      • Szentes, Hungary, 6600
        • Csongrad-Csanad Megyei Dr. Bugyi Istvan Korhaz
      • Székesfehérvár, Hungary, 8000
        • Fejer Varmegyei Szent Gyorgy Egyetemi Oktato Korhaz - II. Belgyogyaszat
  • India
    • Maharashtra
      • Berlin, Maharashtra, India, 10365
        • KEM Hospital
      • Pune, Maharashtra, India, 411004
        • Deenanath Mangeshkar Hospital
    • National Capital Territory of Delhi
      • New Delhi, National Capital Territory of Delhi, India, 110017
        • Max Super Speciality Hospital, Saket
      • New Delhi, National Capital Territory of Delhi, India, 110029
        • Safdarjung Hospital
    • Tamil Nadu
      • Chennai, Tamil Nadu, India, 600037
        • The Madras Medical Mission (MMM)
  • Israel
      • Ashdod, Israel, 7747629
        • Assuta Ashdod Public Hospital (R.A)
      • Ashkelon, Israel, 7830604
        • Barzilai Ashkelon University Medical Center | Cardiology Department
      • Haifa, Israel, 3109601
        • Rambam Health Corporation
      • Haifa, Israel, 3436212
        • Lady Davis Carmel Medical Center
      • Haifa, Israel, 3339419
        • Bnai Zion Medical Center | Cardiology Department
      • Jerusalem, Israel, 9112001
        • Hadassah Hebrew University Hospital Ein Kerem
      • Kfar Saba, Israel, 4428164
        • Meir Medical Center
      • Nahariya, Israel, 2210001
        • Health Corporation of Galilee Medical Center
      • Ramat Gan, Israel, 5262000
        • Chaim Sheba Medical Center
      • Rehovot, Israel, 7610001
        • Kaplan Medical Center
      • Safed, Israel, 1311001
        • Health Corporation of the Ziv Medical Center (R.A.)
      • Tel Aviv, Israel, 6423906
        • Tel-Aviv Sourasky Medical Center
      • Tiberias, Israel, 1528001
        • Poria Medical Center | Cardiovascular Department
      • Ẕerifin, Israel, 7030000
        • Shamir Medical Center (Assaf Harofeh)
  • Italy
    • Calabria
      • Catanzaro, Calabria, Italy, 88100
        • Azienda Ospedaliero Universitaria Renato Dulbecco
    • Campania
      • Napoli, Campania, Italy, 80131
        • Azienda Ospedaliera Universitaria Federico II Di Napoli - DAI Emergenze Cardiovascolari, Medicina Clinica e Dell'Invecchiamento
    • Emilia-Romagna
      • Bologna, Emilia-Romagna, Italy, 40133
        • Azienda Unita Sanitaria Locale Di Bologna_Ospedale Maggiore Pizzardi - Medicina A
      • Bologna, Emilia-Romagna, Italy, 40138
        • Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - Medicina Interna Cardiovascolare
      • Ferrara, Emilia-Romagna, Italy, 44124
        • University Hospital Of Ferrara
      • Piacenza, Emilia-Romagna, Italy, 29121
        • Azienda Unita Sanitaria Locale Di Piacenza
    • Lombardy
      • Bergamo, Lombardy, Italy, 24127
        • Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII - Cardiologia 1
      • Brescia, Lombardy, Italy, 25085
        • Azienda Socio-Sanitaria Territoriale Del Garda
      • Brescia, Lombardy, Italy, 25123
        • Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia - Cardiologia
      • Cremona, Lombardy, Italy, 26100
        • Azienda Socio Sanitaria Territoriale di Cremona
      • Milan, Lombardy, Italy, 20138
        • Centro Cardiologico Monzino S.P.A.
      • Monza Brianza, Lombardy, Italy, 20832
        • Asst Di Monza
      • Pavia, Lombardy, Italy, 27100
        • Irccs Fondazione Policlinico San Matteo
      • Pavia, Lombardy, Italy, 27100
        • Istituti Clinici Scientifici Maugeri S.p.A
      • Rozzano, Lombardy, Italy, 20089
        • Humanitas Mirasole S.p.A. - Cardiologia Clinica e Interventistica
      • Tradate, Lombardy, Italy, 21049
        • ASST Sette Laghi_Ospedale Galmarini - Medicina Generale
      • Vimercate, Lombardy, Italy, 20871
        • Azienda Socio Sanitaria Territoriale Della Brianza _Ospedale di Vimercate - Medicina Interna
    • Piedmont
      • Novara, Piedmont, Italy, 28100
        • A.O.U. Maggiore della Carita
    • Tuscany
      • Cortona, Tuscany, Italy, 52040
        • Azienda Unita' Sanitaria Locale Toscana Sud Est
      • Siena, Tuscany, Italy, 53100
        • Azienda Ospedaliera Universitaria Senese
    • Umbria
      • Perugia, Umbria, Italy, 06129
        • A.O. di Perugia_Hospital Santa Maria della Misericordia - S.C. Cardiologia
    • Veneto
      • Verona, Veneto, Italy, 37126
        • Azienda Ospedaliera Universitaria Integrata Verona_Borgo Trento - Cardiologia
  • Japan
      • Fukuoka, Japan, 814-8522
        • Fukuoka University Nishijin Hospital
      • Gifu, Japan, 500-8717
        • Gifu Prefectural General Medical Center
      • Kumamoto, Japan, 860-8556
        • Kumamoto University Hospital
      • Kumamoto, Japan, 860-0008
        • National Hospital Organization Kumamoto Medical Center
      • Miyazaki, Japan, 880-2102
        • Miyazaki Medical Association Hospital
      • Niigata, Japan, 950-2087
        • Shinrakuen Hospital
      • Okayama, Japan, 700-0804
        • The Sakakibara Heart Institute of Okayama
      • Osaka, Japan, 558-8558
        • Osaka General Medical Center
      • Osaka, Japan, 559-0012
        • Social Corporation Keigakukai Minamiosaka Hospital
      • Osaka, Japan, 543-0035
        • Osaka Police Hospital | Clinical Research and Trial Center
      • Toyama, Japan, 930-0194
        • Toyama University Hospital
      • Wakayama, Japan, 649-6335
        • Seiyu Memorial Hospital
      • Ōita, Japan, 870-8511
        • Oita Prefectural Hospital
    • Aichi-ken
      • Kasugai, Aichi-ken, Japan, 486-8510
        • Kasugai Municipal Hospital
      • Toyota, Aichi-ken, Japan, 471-8513
        • Toyota Memorial Hospital
    • Chiba
      • Funabashi, Chiba, Japan, 273-8588
        • Funabashi Municipal Medical Center
    • Fukuoka
      • Kitakyushu, Fukuoka, Japan, 805-8508
        • Steel Memorial Yawata Hospital
      • Onga-gun, Fukuoka, Japan, 811-4342
        • Onga Nakama Medical Association Onga Hospital
    • Gifu
      • Ōgaki, Gifu, Japan, 503-8502
        • Ogaki Municipal Hospital
    • Hiroshima
      • Shōbara, Hiroshima, Japan, 727-0013
        • Shobara Red Cross Hospital
    • Hyōgo
      • Himeji, Hyōgo, Japan, 670-8560
        • Hyogo Prefectural HarimaHimeji General Medical Center
      • Kobe, Hyōgo, Japan, 654-0155
        • National Hospital Organization Kobe Medical Center
      • Takarazuka, Hyōgo, Japan, 665-0873
        • Higashi Takarazuka Satoh Hospital
    • Ibaraki
      • Toride, Ibaraki, Japan, 302-0022
        • Ja Toride Medical Center
    • Ishikawa-ken
      • Hakusan, Ishikawa-ken, Japan, 924-8588
        • Public Central Hospital of Matto Ishikawa | Clinical Trial Management Office
      • Kanazawa, Ishikawa-ken, Japan, 920-8650
        • National Hospital Organization Kanazawa Medical Center | Clinical Trial Management Office
    • Iwate
      • Morioka, Iwate, Japan, 020-0066
        • Iwate Prefectural Central Hospital
    • Kagawa-ken
      • Takamatsu, Kagawa-ken, Japan, 760-8557
        • Kagawa Prefectural Central Hospital
      • Toyohama-Cho,Kanonji-City, Kagawa-ken, Japan, 769-1695
        • Mitoyo General Hospital | Kagawa, Japan
    • Kanagawa
      • Sagamihara, Kanagawa, Japan, 252-0375
        • Kitasato University Hospital
      • Sagamihara, Kanagawa, Japan, 252-5188
        • Sagamihara Kyodo Hospital
    • Nagano
      • Azumino, Nagano, Japan, 399-8292
        • Japan Red Cross Society Azumino Hospital
      • Ueda, Nagano, Japan, 386-8610
        • National Hospital Organization Shinshu Ueda Medical Center
    • Okinawa
      • Naha, Okinawa, Japan, 902-8511
        • R.I.A.C Naha City Hospital
    • Osaka
      • Kishiwada, Osaka, Japan, 596-0042
        • Kishiwada Tokushukai Hospital
      • Takatsuki, Osaka, Japan, 569-1045
        • Takatsuki Red Cross Hospital
    • Saitama
      • Ageo, Saitama, Japan, 362-8588
        • Ageo Central General Hospital
      • Kawaguchi, Saitama, Japan, 333-0842
        • Kawaguchi Cardiovascular and Respiratory Hospital
      • Sayama, Saitama, Japan, 350-1305
        • Saitama Sekishinkai Hospital
    • Shimane
      • Hamada, Shimane, Japan, 697-8511
        • National Hospital Organization Hamada Medical Center
    • Tokyo
      • Adachi-ku, Tokyo, Japan, 123-0845
        • Nishiarai Heart Central Clinic
      • Hachiōji, Tokyo, Japan, 192-0918
        • Minamino Cardiovascular Hospital
      • Meguro-ku, Tokyo, Japan, 152-8902
        • National Hospital Organization Tokyo Medical Center
      • Ōta-ku, Tokyo, Japan, 143-8541
        • Toho University Omori Medical Center
    • Tottori
      • Yonago, Tottori, Japan, 683-8605
        • Japan Organization of Occupational Health and Safety Sanin Rosai Hospital
    • Yamaguchi
      • Iwakuni, Yamaguchi, Japan, 740-8510
        • National Hospital Organization Iwakuni Clinical Center
      • Shimonoseki, Yamaguchi, Japan, 750-0061
        • JCHO Shimonoseki Medical Center
  • Latvia
      • Daugavpils, Latvia, LV-5417
        • Daugavpils Regional Hospital
      • Jelgava, Latvia, LV-3001
        • Jelgava Outpatient Clinic
      • Liepāja, Latvia, LV-3414
        • Liepaja Regional Hospital
      • Riga, Latvia, LV-1002
        • P. Stradins Clinical University Hospital
      • Riga, Latvia, LV-1001
        • 1st Riga Clinical Hospital
      • Riga, Latvia, LV-1024
        • GK Neiroklinika
      • Ventspils, Latvia, LV-3601
        • Gita Rancane - cardiology private practice
  • Lithuania
      • Alytus, Lithuania, LT-63200
        • UAB "Klinikiniai sprendimai" Alytus
      • Kaunas, Lithuania, LT-44320
        • LUHS Kauno Hospital (Laisves ave.)
      • Kaunas, Lithuania, LT-47144
        • LUHS Kauno Hospital (Josvainiu str.)
      • Kaunas, Lithuania, LT-49449
        • Saules family medicine center
      • Klaipėda, Lithuania, LT-92288
        • Klaipedos Jurininku Ligonine
      • Vilnius, Lithuania, LT-08661
        • Vilnius University hospital Santaros klinikos
      • Šiauliai, Lithuania, 76231
        • Siauliai Republican Hospital
  • Malaysia
      • George Town, Malaysia, 10050
        • Gleneagles Penang Medical Center
      • Kuala Lumpur, Malaysia, 59100
        • University Malaya Medical Centre
      • Kuala Lumpur, Malaysia, 50400
        • Institute Jantung Negara
      • Kuala Selangor, Malaysia, 43000
        • Hospital Sultan Idris Shah Serdang (Hospital Serdang)
      • Perak, Malaysia, 30450
        • Hospital Raja Permaisuri Bainun
      • Pulau Pinang, Malaysia, 10450
        • Hospital Pulau Pinang
      • Sarawak, Malaysia, 94300
        • Sarawak Heart Centre
  • Mexico
      • Aguascalientes, Mexico, 20230
        • Hospital Cardiologica Aguascalientes
      • Durango, Mexico, 34080
        • Centro de Investigacion y Atencion Integral Durango S.C.
    • Coahuila
      • Torreón, Coahuila, Mexico, 27000
        • Centro de Investigación Médica Dr. Alberto Bazzoni SA de CV
    • Guerrero
      • Acapulco de Juárez, Guerrero, Mexico, 39910
        • Hospital General de Acapulco
    • Jalisco
      • Guadalajara, Jalisco, Mexico, 44657
        • Consultorio de Medicina Especializada del Sector Privado
    • Mexico City
      • Alcaldia Gustavo A. Madero, Mexico City, Mexico, 7300
        • Fundación de Atencion e Investigacion Medica Lindavista SC
      • Alcaldía Cuauhtemoc, Mexico City, Mexico, 6090
        • Hospital de Jesús
    • Querétaro
      • Querétaro City, Querétaro, Mexico, 76000
        • Centro de Estudios Clinicos de Queretaro S. C. (CECLIQ)
    • Veracruz
      • Xalapa, Veracruz, Mexico, 91193
        • Hospital Angeles de Xalapa
  • Netherlands
      • Almelo, Netherlands, 7609 PP
        • Ziekenhuis Groep Twente
      • Deventer, Netherlands, 7416 SE
        • Deventer Ziekenhuis
      • Doetinchem, Netherlands, 7009 BL
        • Slingeland Ziekenhuis
      • Ede, Netherlands, 6716 RP
        • Ziekenhuis Gelderse Vallei
      • Groningen, Netherlands, 9713 GZ
        • Universitair Medisch Centrum Groningen
      • Harderwijk, Netherlands, 3844 DG
        • Ziekenhuis St. Jansdal
      • Hilversum, Netherlands, 1212 VG
        • Tergooiziekenhuizen-Blaricum
      • Maastricht, Netherlands, 6229 HX
        • Maastricht UMC
      • Meppel, Netherlands, 7943 KA
        • Isala Meppel
      • Sneek, Netherlands, 8601 ZR
        • Antonius Ziekenhuis Sneek
      • Tilburg, Netherlands, 5042 AD
        • ETZ TweeSteden Ziekenhuis (vh Maria Ziekenhuis)
      • Veldhoven, Netherlands, 5504 DB
        • Maxima Medisch Centrum, locatie Veldhoven
    • North Brabant
      • Eindhoven, North Brabant, Netherlands, 5623 EJ
        • Catharina Ziekenhuis
  • New Zealand
      • Auckland, New Zealand, 1023
        • University of Auckland
      • Christchurch, New Zealand, 8140
        • Christchurch Heart Institute
      • Dunedin, New Zealand, 9016
        • Dunedin Hospital
      • Hawkes Bay, New Zealand, 4130
        • P3 Research Ltd Tauranga
      • Lower Hutt, New Zealand, 5010
        • Hutt Hospital
      • Nelson, New Zealand, 7042
        • Nelson Hospital
      • Tauranga, New Zealand, 3110
        • P3 Research
  • Poland
      • Bialystok, Poland, 15-704
        • Klimed Marek Klimkiewicz
      • Bydgoszcz, Poland, 85-065
        • MICS Centrum Medyczne Bydgoszcz
      • Gdynia, Poland, 81-519
        • Uniwersyteckie Centrum Medycyny Morskiej i Tropikalnej
      • Grodzisk Mazowiecki, Poland, 05 825
        • Samodzielny Publiczny Specjalistyczny Szpital Zachodni im. sw. Jana Pawla II
      • Katowice, Poland, 40-156
        • CLINICAL MEDICAL RESEARCH Sp. z o. o.
      • Krakow, Poland, 31-271
        • Unicardia Specjalistyczne Centrum Leczenia Ch.Serca i Naczyn
      • Lublin, Poland, 20-857
        • NZOZ "Twoja Przychodnia" Sp. z o.o.
      • Lublin, Poland, 20-068
        • IMEDICA Centrum Medyczne
      • Olsztyn, Poland, 10-010
        • Zechowicz Medeusz-Plus Lekarska Spolka Partnerska
      • Oświęcim, Poland, 32-600
        • Oswiecimskie Centrum Badan Klinicznych Medicome Sp. z o.o.
      • Poznan, Poland, 61-848
        • Uniwersytecki Szpital Kliniczny W Poznaniu
      • Puławy, Poland, 24-100
        • Szpital Specjalistyczny SPZOZ
      • Sopot, Poland, 81-717
        • NZOZ Pro-Cordis Sopockie Centrum Badan Kardiologicznych
      • Szczecin, Poland, 71-500
        • Twoja Przychodnia - Szczecinskie Centrum Medyczne
      • Torun, Poland, 87-100
        • Gessek Jacek Prywatny Gabinet Lekarski
  • Portugal
      • Amadora, Portugal, 2720-276
        • Hospital Prof. Dr. Fernando Fonseca
      • Aveiro, Portugal, 3810-501
        • BlueClinical | Centro Hospitalar Baixo Vouga - Unidade Aveiro - Gabinete de Ensaios Clinicos
      • Coimbra, Portugal, 3004-561
        • Unidade Local de Saúde de Coimbra, E.P.E. - Cardiology Department - Research Unit
      • Guarda, Portugal, 6300-659
        • ULSG - Unidade Local de Saude da Guarda
      • Leiria, Portugal, 2410-197
        • Centro Hospitalar de Leiria | Santo Andre Hospital - Research Center
      • Lisbon, Portugal, 1449-005
        • Unidade Local De Saúde De Lisboa Ocidental E.P.E.
      • Lisbon, Portugal, 1500-650
        • Luz Saude | Hospital da Luz Lisboa - Centro de Investigacao Clinica
      • Porto, Portugal, 4099-001
        • Centro Hospitalar Universitario do Porto
    • Braga District
      • Guimaraes, Braga, Braga District, Portugal, 4835-044
        • Hospital da Senhora da Oliveira | Clinical Research Department
    • Castelo Branco District
      • Covilha, Castelo Branco District, Portugal, 6200-251
        • Centro Hospitalar Universitario Cova de Beira | Clinical Research Department
    • Porto District
      • Matosinhos Municipality, Porto District, Portugal, 4464-513
        • Hospital Pedro Hispano | Clinical Research Center
    • Setúbal District
      • Setúbal, Setúbal District, Portugal, 2900-722
        • Luz Saude | Hospital da Luz Setubal - Clinical Research Department
  • Romania
      • Baia Mare, Romania, 430031
        • Sp. Judetean de Urgenta Dr. Constantin Opris Baia Mare
      • Brasov, Romania, 500102
        • S.C Thera Card S.R.L
      • Brăila, Romania, 810318
        • Emergency County Hospital, Braila
      • Bucharest, Romania, 22322
        • Emergency Institute for Cardiovascular Diseases
      • Bucharest, Romania, 50098
        • Spitalul Universitar de Urgenta Bucuresti
      • Bucharest, Romania, TBC
        • Spitalul Clinic de Urgenta "Sf. Pantelimon"
      • Craiova Dolj, Romania, 200642
        • Spitalul Clinic Judetean De Urgenta Craiova
      • Galati, Romania, 800578
        • Sf. Ap. Andrei Emergency Clinical County Hospital Galati
      • Iași, Romania, 700732
        • S.C. CARDIOMED S.R.L. Iasi
      • Piteşti, Romania, TBC
        • S.C. Sal Med SRL
      • Timișoara, Romania, 300310
        • Institutul de Boli Cardiovasculare Timisoara
      • Târgu Mureş, Romania, 540124
        • S.C. Cardio Med S.R.L.
    • Mureș County
      • Târgu Mureş, Mureș County, Romania, TBC
        • CMI. Dr. Podoleanu Cristian
    • Timiș County
      • Timișoara, Timiș County, Romania, 300040
        • Spitalul Clinic Municipal de Urgenta "Timisoara"
      • Timișoara, Timiș County, Romania, 300254
        • Municipal Clinical Emergency Hospital of Timisoara
  • Russia
      • Aramil, Russia, 624003
        • SBHI of Sverdlovsk Region Aramil City Hospital
      • Arkhangelsk, Russia, 163001
        • First City Clinical Hospital n.a. E.E. Volosevich
      • Barnaul, Russia, 656055
        • Altai Regional Cardiological Dispensary
      • Chita, Russia, 672000
        • SBEI "Chita State Medical Academy"
      • Izhevsk, Russia, 426063
        • Izhevsk City Clinical Hospital #9
      • Kazan', Russia, 420043
        • Kazan Federal University
      • Kazan', Russia, 420101
        • Clinical Diagnostic Center
      • Kemerovo, Russia, 650002
        • Sci-Res. Institute of Complex Cardiovascular Disorders
      • Kirov, Russia, 610014
        • Center of Cardiology and Neurology
      • Moscow, Russia, 101990
        • Research center of therapy and prophylactic medicine
      • Moscow, Russia, 111020
        • City Clinical Hospital #29 n.a. N.E. Bauman - Clinical-Diagnostic dept
      • Moscow, Russia, 117292
        • City clinical hospital n.a. V.V. Vinogradov
      • Moscow, Russia, 119192
        • Moscow State University n.a. M.V. Lomonosov
      • Moscow, Russia, 129226
        • Russian Clinical and Research Center of Gerontology
      • Novosibirsk, Russia, 630087
        • State Novosibirsk regional clinical hospital
      • Omsk, Russia, 644018
        • Omsk Region "Clinical Health Unit No. 9"
      • Penza, Russia, 440026
        • Penza Regional Clinical Hospital n.a. N.N. Burdenko
      • Perm, Russia, 614097
        • Perm Regional Hospital for War Veterans
      • Rostov-on-Don, Russia, 344068
        • Rostov-on-Don Emergency Clinical Hospital
      • Ryazan, Russia, 390039
        • SBI of the Ryazan region "Regional clinical hospital"
      • Saint Petersburg, Russia, 192242
        • Scien. Res. Inst. of Emergency Care n.a. I.I. Dzhanelidze
      • Saint Petersburg, Russia, 194017
        • St. Petersburg Clinical Hospital of RAS
      • Saint Petersburg, Russia, 199226
        • LLC Astarta
      • Samara, Russia, 443070
        • Samara Regional Clinical Cardiology Dispensary n.a. Polyakov
      • Saratov, Russia, 410054
        • Clinical Hospital #3 n.a. S.R. Mirotvortsev
      • Tomsk, Russia, 634012
        • Scientific Research Institute of Cardiology
      • Tomsk, Russia, 634063
        • Tomsk Regional Clinical Hospital
      • Yekaterinburg, Russia, 620102
        • Sverdlovsk Regional Clinical Hospital #1
  • Slovakia
      • Banská Bystrica, Slovakia, 974 01
        • Stredoslovenský ústav srdcových a cievnych chorôb, a.s.
      • Bardejov, Slovakia, 085 01
        • ALIAN s.r.o.
      • Bratislava, Slovakia, 813 69
        • Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto
      • Bratislava, Slovakia, 84107
        • Kardiosanus | Bratislava, Slovakia
      • Bratislava, Slovakia, 84103
        • Centrum interv. neuroradiologie a endovaskularnej liecby
      • Bratislava, Slovakia, 81108
        • Nemocnica svateho Michala, a.s.
      • Bratislava, Slovakia, 833 48
        • Narodny ustav srdcovych a cievnych chorob, a.s
      • Brezno, Slovakia, 977 01
        • Nemocnica s poliklinikou Brezno, n.o.
      • Dolný Kubín, Slovakia, 026 14
        • Dolnooravska nemocnica s poliklinikou L. Nadasi Jegeho
      • Košice, Slovakia, 040 01
        • JG-COR s.r.o.
      • Košice, Slovakia, 04001
        • Medical Group Kosice s.r.o. | Kosice, Slovakia
      • Levice, Slovakia, 93401
        • KARDIO-ANGIO s.r.o.
      • Lučenec, Slovakia, 984 01
        • Kardiomed s.r.o.
      • Moldava nad Bodvou, Slovakia, 045 01
        • MEDI M&M, s.r.o.
      • Nitra, Slovakia, 949 01
        • Kardiocentrum Nitra | Cardiology Clinic - Outpatient Department
      • Nové Zámky, Slovakia, 940 01
        • KARDIOMED NZ s.r.o.
      • Prešov, Slovakia, 08001
        • Medispol s.r.o.
      • Šahy, Slovakia, 936 01
        • COR, s.r.o
      • Žilina, Slovakia, 1001
        • MEDIVASA s.r.o.
  • South Korea
      • Busan, South Korea, 49201
        • Dong-A University Hospital
      • Busan, South Korea, 49241
        • Pusan National University Hospital
      • Daejeon, South Korea, 35015
        • Chung Nam National University Hospital
      • Gwangju, South Korea, 501-757
        • Chonnam National University Hospital
    • Gang''weondo
      • Wŏnju, Gang''weondo, South Korea, 26426
        • Yonsei University Wonju Christian Hospital
    • Gyeonggido
      • Anyang-si, Gyeonggido, South Korea, 14068
        • Hallym University Sacred Heart Hospital
      • Seongnam-si, Gyeonggido, South Korea, 13496
        • Bundang CHA hospital
    • North Chungcheong
      • Cheongju-si, North Chungcheong, South Korea, 28644
        • Chungbuk National University Hospital
    • Seoul Teugbyeolsi
      • Seoul, Seoul Teugbyeolsi, South Korea, 3080
        • Seoul National University Hospital
      • Seoul, Seoul Teugbyeolsi, South Korea, 03722
        • Severance Hospital, Yonsei University Health System
  • Spain
      • A Coruña, Spain, 15006
        • Instituto Medico Quirurgico San Rafael S.A. - Cardiologia
      • Barcelona, Spain, 08003
        • Hospital del Mar
      • Barcelona, Spain, 08035
        • Ciutat Sanitaria i Universitaria de la Vall d'Hebron
      • Barcelona, Spain, 8908
        • Hospital Universitari de Bellvitge (HUB)
      • Granada, Spain, 18014
        • Hospital Universitario Virgen De Las Nieves - Cardiologia
      • Lleida, Spain, 25198
        • Hospital Universitari Arnau De Vilanova De La Gerencia Territorial De Lleida - Medicina Interna
      • Madrid, Spain, 28041
        • Hospital Universitario 12 de Octubre
      • Madrid, Spain, 28034
        • Hospital Ramón y Cajal | Medicina Interna
      • Madrid, Spain, 28023
        • Hospital Universitario La Zarzuela - Cardiologia
      • Seville, Spain, 41014
        • Hospital Universitario Virgen de Valme - Medicina Interna
      • Valencia, Spain, 46014
        • Hospital General Universitario de Valencia
      • Valencia, Spain, 46010
        • Hospital Clinico Universitario de Valencia (CHUV)
      • Valencia, Spain, 46026
        • Hospital Universitario Y Politecnico La Fe - Cardiologia
      • Valencia, Spain, 46940
        • Hospital de Manises - Medicina Interna
    • A Coruña
      • Ferrol, A Coruña, Spain, 15405
        • Complejo Hospitalario Universitario de Ferrol | Hospital Naval - Unidad de Hipertensión Arterial
    • Alicante
      • San Bartolomé, Alicante, Spain, 03314
        • Hospital Vega Baja De Orihuela - Medicina Interna
    • Cádiz
      • El Puerto de Santa María, Cádiz, Spain, 11500
        • Hospital Santa María del Puerto - Medicina Interna
      • Sanlúcar de Barrameda, Cádiz, Spain, 11540
        • Hospital Virgen del Camino - Medicina Interna
      • Villamartín, Cádiz, Spain, 11650
        • Hospital Virgen De Las Montanas - Medicina Interna
    • Las Palmas
      • Las Palmas de Gran Canaria, Las Palmas, Spain, 35010
        • Hospital Universitario de Gran Canaria Dr. Negrin - Cardiologia
    • Málaga
      • Málaga, Málaga, Spain, 29010
        • Hospital Universitario Virgen De La Victoria - Cardiologia
    • Principality of Asturias
      • Oviedo, Principality of Asturias, Spain, 33011
        • Hospital Central de Asturias
    • Sevilla
      • Utrera, Sevilla, Spain, 41710
        • Hospital Alta Resolucion de Utrera - Cardiologia
  • Taiwan
      • Changhua, Taiwan, 50006
        • Changhua Christian Hospital
      • Hsinchu, Taiwan, 300
        • Mackay Memorial Hospital - Hsinchu Branch
      • Taichung, Taiwan, 40705
        • Taichung Veterans General Hospital
      • Taipei, Taiwan, 100
        • National Taiwan University Hospital
      • Taipei, Taiwan, 11217
        • Taipei Veterans General Hospital
      • Taipei, Taiwan, 100
        • Taipei Medical University Hospital
      • Taoyuan District, Taiwan, 33305
        • Chang Gung Memorial Hospital at Linkou
    • Kaohsiung
      • Kaohsiung City, Kaohsiung, Taiwan, 807377
        • Kaohsiung Medical University Chung-Ho Memorial Hospital
  • Turkey (Türkiye)
      • Afyonkarahisar, Turkey (Türkiye), 3218
        • Afyonkarahisar Saglik Bilimleri Universitesi
      • Antalya, Turkey (Türkiye), 7100
        • Saglik Bilimleri Universitesi Antalya EA Hastanesi
      • Edirne, Turkey (Türkiye), 22030
        • Trakya Univ. Tip Fak.
      • Eskişehir, Turkey (Türkiye), 26480
        • Eskisehir Osmangazi Universitesi Tip Fakultesi
      • Istanbul, Turkey (Türkiye), 34098
        • Istanbul Universitesi Cerrahpasa-Cerrahpasa Tip Fakultesi
      • Istanbul, Turkey (Türkiye), 34304
        • Istanbul Universitesi Kardiyoloji Enstitusu
      • Istanbul, Turkey (Türkiye), TBC
        • Istanbul Mehmet Akif Ersoy Gogus Kalp Damar Cerrahisi E.A.H.
      • Izmir, Turkey (Türkiye), 35340
        • Dokuz Eylul Universitesi Tip Fakultesi
      • Kayseri, Turkey (Türkiye), 38039
        • Erciyes Universitesi Tip Fakultesi
      • Kocaeli, Turkey (Türkiye), 41380
        • Kocaeli Universitesi Tip Fakultesi
      • Konya, Turkey (Türkiye), 42080
        • Necmettin Erbakan Universitesi Meram Tip Fakultesi Hastanesi
      • Kütahya, Turkey (Türkiye), 43040
        • Kutahya Saglik Bilimleri Uni. Evliya Celebi Egitim ve Arasti
      • Mersin, Turkey (Türkiye), 33079
        • Mersin Universitesi Tip Fakultesi
  • Ukraine
      • Cherkasy, Ukraine, 18009
        • MNPE "Cherkasy Regional Cardiology Center" - Department of Coronary Heart Disease and Non-Coronary Myocardial Diseases
      • Dnipro, Ukraine, 49006
        • Clinical Emergency Hospital" of Dnipro City Council - Department of Cardiology
      • Kharkiv, Ukraine, 61039
        • National Institute of Therapy L.T.Maloyi, Department of Chronic Non-Communicable Diseases
      • Kharkiv, Ukraine, 61166
        • Regional Dispensary of Radiation Protection of Population - Cardiology Department
      • Kharkiv, Ukraine, 61176
        • MNPE "City Clinical Hospital No. 8" of the Kharkiv City Council, Cardiology Department No. 2
      • Kiev, Ukraine, 02 091
        • Municipal Non-Profit Enterprise "Kyiv City Clinical Hospital No. 1" - Department of Cardiology
      • Kyiv, Ukraine, 3049
        • Railway Clinical Hospital #2
      • Kyiv, Ukraine, 03037
        • Medical Center "Medbud" - Treatment and prophylactic department
      • Kyiv, Ukraine, 03151
        • National Scientific Center Institute of Cardiology named M.D. Strazhesko of the NAMSU - Department of Cardiac Arrhythmias
      • Kyiv, Ukraine, 03151
        • National Scientific Center Institute of Cardiology named M.D. Strazhesko of the NAMSU - Department of Heart Failure
      • Kyiv, Ukraine, 03151
        • National Scientific Center Institute of Cardiology named M.D. Strazhesko of the NAMSU - Department of Hypertension
      • Kyiv, Ukraine, 04050
        • LLC "Medical Center "Consilium Medical", Clinical and Consultative Departmen 1
      • Lviv, Ukraine, 79015
        • Lviv Regional Clinical Treatment and Diagnostic Cardiology Center, consulting polyclinic
      • Poltava, Ukraine, 36011
        • Poltava Regional Clinical Hospital. M.V. Sklifosovsky, Cardiology Department
      • Uzhhorod, Ukraine, 880000
        • Zakarpatsky Oblasnyi Kardiologichnyi Dyspanser, Infarction department
      • Vinnytsia, Ukraine, 21018
        • Vinnytsia Regional Clinical Hospital, Clinical Cardiology Department
      • Vinnytsia, Ukraine, 21029
        • Vinnytsia City Clinical Hospital #1, Therapeutic Department
      • Zaporizhzhia, Ukraine, 69005
        • Regional Medical Center for Cardiovascular Diseases-Heart failure department
      • Zaporizhzhya, Ukraine, 69001
        • Zaporizhia Municipal Clinical Hospital No.10, Cardiology Department
      • Zaporizhzhya, Ukraine, 69005
        • Zaporizhzhya City Emergency Care Hospital, Cardiology Department
      • Zhytomyr, Ukraine, 10002
        • Hospital No. 1 of the Zhytomyr City - consulting and treatment department Scientific and research center
  • United Kingdom
      • Cottingham, United Kingdom, HU16 5JQ
        • Hull University Teaching Hospitals NHS Trust | Castle Hill Hospital - Cardiology
      • Glasgow, United Kingdom, G31 2ER
        • NHS Greater Glasgow and Clyde | Glasgow Royal Infirmary |Glasgow Research Facility - Cardiology
      • Manchester, United Kingdom, M13 9WL
        • Manchester Royal Infirmary
      • Swindon, United Kingdom, SN3 6BB
        • Great Western Hospital
    • Dorset
      • Bournemouth, Dorset, United Kingdom, BH7 7DW
        • Royal Bournemouth General Hospital
      • Poole, Dorset, United Kingdom, BH15 2JB
        • Poole Hospital NHS Trust
    • Glasgow City
      • Glasgow, Glasgow City, United Kingdom, G51 4TF
        • Queen Elizabeth University Hospital
    • Hampshire
      • Basingstoke, Hampshire, United Kingdom, RG24 9NA
        • North Hampshire Hospital
    • Hertfordshire
      • Stevenage, Hertfordshire, United Kingdom, SG1 4AB
        • Lister Hospital
    • Lancashire
      • Blackpool, Lancashire, United Kingdom, FY3 8NR
        • Blackpool Victoria Hospital
    • Leicestershire
      • Leicester, Leicestershire, United Kingdom, LE3 9QP
        • University Hospitals Leicester
    • Northumberland
      • Ashington, Northumberland, United Kingdom, NE63 9JJ
        • Wansbeck General Hospital
    • West Midlands
      • Dudley, West Midlands, United Kingdom, DY1 2HQ
        • Dudley Group NHS Foundation Trust ¦Russells Hall Hopsital - Oncology
    • West Sussex
      • Chichester, West Sussex, United Kingdom, PO19 6SE
        • University Hospitals Sussex NHS Foundation Trust | St Richard's Hospital - Cardiology services
  • United States
    • Alabama
      • Birmingham, Alabama, United States, 35211
        • Cardiology, PC
      • Fairhope, Alabama, United States, 36532
        • Eastern Shore Research Institute, LLC | Fairhope, AL
      • Mobile, Alabama, United States, 36608
        • Mobile Heart Specialists - Providence
    • Arizona
      • Tucson, Arizona, United States, 85724
        • University of Arizona Clinical and Translational Sciences Research Center
    • Arkansas
      • Little Rock, Arkansas, United States, 72205
        • Heart Clinic Arkansas
    • California
      • Beverly Hills, California, United States, 90211
        • WestSide Medical
      • Huntington Beach, California, United States, 92648
        • CA Heart and Vein Specialists
      • Orange, California, United States, 92868
        • UCI Medical Center - Neurology
      • Sacramento, California, United States, 95816
        • Sutter Medical Center - Cardiology
      • Santa Rosa, California, United States, 95405
        • NorthBay Clinical Research, LLC | Santa Rosa, CA
      • Torrance, California, United States, 90502
        • The Lundquist Institute - Gynecology
      • Vista, California, United States, 92081
        • Blue Coast Research Center, LLC
      • West Hills, California, United States, 91307
        • Interventional Cardio Medical- DCT Department
      • West Hills, California, United States, 91307
        • Interventional Cardiology Medical Group | West Hills, CA
    • Colorado
      • Aurora, Colorado, United States, 80045
        • VA Eastern Colorado Health Care System
      • Colorado Springs, Colorado, United States, 80923
        • Colorado Springs Cardiology - Woodmen Medical Plaza
      • Littleton, Colorado, United States, 80120
        • South Denver Cardiology Associates, PC
    • Florida
      • Bradenton, Florida, United States, 34209
        • Cardiovascular & Vein Center of Florida | Bradenton, FL
      • Bradenton, Florida, United States, 34209
        • Nova Clinical Research - Blake Medical Center
      • Daytona Beach, Florida, United States, 32117
        • Cardiology Associates Research Company
      • Gainesville, Florida, United States, 32608
        • North Florida Foundation for Research and Education - Clinical Trial Center
      • Miami, Florida, United States, 33130
        • LifeSpring Research Foundation, LLC
      • Naples, Florida, United States, 34102-8143
        • Southwest Florida Research | Naples, FL
      • Saint Augustine, Florida, United States, 32086
        • East Coast Institute for Research | St. Augustine, FL
      • Wellington, Florida, United States, 33449
        • Cardiology Partners Clinical Research Institute | Wellington Office
    • Georgia
      • Columbus, Georgia, United States, 31904
        • Centricity Research at Talbotton
      • Tucker, Georgia, United States, 30084
        • Atlanta Heart Specialists - Tucker
    • Illinois
      • Chicago, Illinois, United States, 60657
        • Advocate Illinois Masonic Medical Center - Cardiology
      • Downers Grove, Illinois, United States, 60515
        • Advocate Good Samaritan Hospital - Cardiology
      • Libertyville, Illinois, United States, 60048
        • Advocate Condell Medical Center
      • Naperville, Illinois, United States, 60540
        • Edward Hospital - Main Campus - Cardiology
      • North Chicago, Illinois, United States, 60064
        • Captain James A. Lovell Federal Health Care Center
      • Peoria, Illinois, United States, 61603
        • Carle Health Methodist Hospital - Cardiology
    • Indiana
      • Elkhart, Indiana, United States, 46514
        • Midwest Cardiovascular Research and Education Foundation | Elkhart, IN
      • Richmond, Indiana, United States, 47374
        • Reid Physicians Associates - Cardiology Department
    • Kansas
      • Wichita, Kansas, United States, 67214
        • Kansas Nephrology Research Institute
    • Kentucky
      • Paducah, Kentucky, United States, 42003
        • Baptist Health Paducah - Cardiology
    • Louisiana
      • Covington, Louisiana, United States, 70433
        • Cardiovascular Associates Research, LLC
      • Hammond, Louisiana, United States, 70403
        • Heart Clinic of Hammond
      • Slidell, Louisiana, United States, 70458
        • Louisiana Heart Center - Slidell
      • Zachary, Louisiana, United States, 70791
        • Southern Clinical Research, LLC
    • Maine
      • Scarborough, Maine, United States, 04039
        • MaineHealth Cardiology - Scarborough
    • Maryland
      • Baltimore, Maryland, United States, 21287
        • Johns Hopkins Hospital - Cardiology
      • Bethesda, Maryland, United States, 20814
        • Suburban Hospital - Cardiology
      • Columbia, Maryland, United States, 21044
        • Cardiovascular Specialists of Central Maryland, PA
    • Michigan
      • Detroit, Michigan, United States, 48202
        • Henry Ford Hospital - OB/GYN
      • Flint, Michigan, United States, 48504
        • AA Medical Research Center | Flint, MI
    • Minnesota
      • Maplewood, Minnesota, United States, 55109
        • M Health Fairview Heart Clinic - Maplewood
      • Minneapolis, Minnesota, United States, 55455
        • M Health Fairview Heart Clinic - Fulton
      • Saint Cloud, Minnesota, United States, 56303
        • St. Cloud Hospital
    • Mississippi
      • Jackson, Mississippi, United States, 39202
        • Baptist Heart -Cardiology - DCT Dept
      • Jackson, Mississippi, United States, 39216
        • University Hospital - UMMC - Nephrology
    • Missouri
      • Columbia, Missouri, United States, 65201
        • Harry S Truman Memorial Veterans Hospital - Cardiology
      • Kansas City, Missouri, United States, 64111
        • Saint Luke's Mid America Heart Institute
      • Kansas City, Missouri, United States, 64111
        • Clinical Research Consultants
      • Springfield, Missouri, United States, 65804
        • Mercy Hospital Springfield - Cardiology
    • Montana
      • Kalispell, Montana, United States, 59901
        • Logan Health Research
    • Nebraska
      • Grand Island, Nebraska, United States, 68803
        • CHI Health Clinic Heart Institute - Grand Island
      • Lincoln, Nebraska, United States, 68526
        • CHI Health Nebraska Heart
    • New Jersey
      • Bridgewater, New Jersey, United States, 08807
        • Advanced Heart Care, LLC | Bridgewater, NJ
      • Linden, New Jersey, United States, 07036
        • NJ Heart | Linden, NJ
      • Manalapan, New Jersey, United States, 07726
        • Garden State Heart Care
    • New York
      • Poughkeepsie, New York, United States, 12601
        • Nuvance Health - The Heart Center
      • Riverhead, New York, United States, 11901
        • Division of Cardiovascular Research at Peconic Bay Medical Center
      • Rosedale, New York, United States, 11422
        • Laurelton Heart Specialists
      • Saratoga Springs, New York, United States, 12866
        • Saratoga Clinical Research, LLC
      • The Bronx, New York, United States, 10469
        • Cardiac Care & Vascular Medicine
      • Valley Stream, New York, United States, 11580
        • Northwell Health Physician Partners Cardiology at Valley Stream
    • North Carolina
      • Burlington, North Carolina, United States, 27215
        • Kernodle Clinic West
      • Chapel Hill, North Carolina, United States, 27514
        • University of North Carolina
      • Winston-Salem, North Carolina, United States, 27157
        • Wake Forest Baptist Health
    • Ohio
      • Kettering, Ohio, United States, 45429
        • Kettering Health Network | Research Institute
      • Marion, Ohio, United States, 43302-6774
        • Rama Research LLC | Marion, OH
      • Youngstown, Ohio, United States, 44501
        • Mercy Health - St. Elizabeth Youngstown Hospital
    • Oklahoma
      • Oklahoma City, Oklahoma, United States, 73135
        • South Oklahoma Heart Research, LLC
    • Pennsylvania
      • Camp Hill, Pennsylvania, United States, 17011
        • Capital Area Research | Camp Hill, PA
      • Doylestown, Pennsylvania, United States, 18901
        • Doylestown Health Cardiology - DCA
    • Rhode Island
      • Warwick, Rhode Island, United States, 02886
        • Kent Hospital
    • South Carolina
      • Ladson, South Carolina, United States, 29456
        • Trident Cardiology Associates, PA
      • Lancaster, South Carolina, United States, 29720
        • Carolina Heart Specialists | Lancaster, SC
    • South Dakota
      • Rapid City, South Dakota, United States, 57701
        • Monument Health Clinical Research
      • Sioux Falls, South Dakota, United States, 57105
        • Sanford USD Medical Center - Cardiology
    • Tennessee
      • Germantown, Tennessee, United States, 38138
        • The Stern Cardiovascular Foundation - Germantown, TN
      • Jackson, Tennessee, United States, 38301
        • Apex Research Foundation, LLC. | Jackson, TN
      • Memphis, Tennessee, United States, 38105
        • Lt. Col. Luke Weathers, Jr. VA Medical Center - Cardiology
      • Powell, Tennessee, United States, 37849
        • Cardiovascular Research of Knoxville
    • Texas
      • Austin, Texas, United States, 78705
        • Ascension Seton Heart Specialty Care and Transplant Center
      • Dallas, Texas, United States, 75235
        • Southwest Family Medicine Associates | Dallas, TX
      • Dallas, Texas, United States, 75231
        • Texas Health & Vascular Specialists - Dallas
      • Fort Worth, Texas, United States, 76107
        • Texas Health Family Care - W Vickery Blvd
      • Galveston, Texas, United States, 77555
        • University of Texas Medical Branch at Galveston
      • Humble, Texas, United States, 77338
        • Houston Heart & Vascular Associates
      • Kerrville, Texas, United States, 78028
        • South Texas Cardiovascular Consultants, PLLC / Kerrville, TX
      • McKinney, Texas, United States, 75069
        • North Dallas Research Associates
      • Plano, Texas, United States, 75024
        • ClinRx Research, LLC
      • San Antonio, Texas, United States, 78212
        • Clinical Advancement Center, PLLC
      • San Antonio, Texas, United States, 78201
        • South Texas Cardiovascular Consultants - San Antonio
      • Tomball, Texas, United States, 77375
        • Northwest Houston Clinical Research - Tomball
    • Utah
      • Salt Lake City, Utah, United States, 84312
        • University of Utah Clinical Neurosciences Center
    • Virginia
      • Fairfax, Virginia, United States, 22031
        • Inova Cardiology- Fairfax
      • Falls Church, Virginia, United States, 22042
        • Virginia Heart
      • Leesburg, Virginia, United States, 20176
        • Virginia Heart - Leesburg
      • Norfolk, Virginia, United States, 23507
        • Sentara Norfolk General Hospital
      • Salem, Virginia, United States, 24153
        • Salem VA Medical Center - Cardiology
      • Winchester, Virginia, United States, 22601
        • Selma Medical Associates
    • Wisconsin
      • Madison, Wisconsin, United States, 53705
        • William S. Middleton Memorial Veterans Hospital
      • Milwaukee, Wisconsin, United States, 53215
        • Aurora Saint Luke's Medical Center - Cardiology

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

40 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Participant (male or female) must be aged 40 years and older.
  • Diagnosis of heart failure with New York Heart Association(NYHA) class II-IV, ambulatory or hospitalized primarily for heart failure.
  • On diuretic treatment for at least 30 days prior to randomization.
  • Documented left ventricular ejection fraction (LVEF) of ≥40% measured by any modality within the last 12 months.
  • Structural heart abnormalities based on any local imaging measurement within the last 12 months, defined by at least one of the following findings: left atrial diameter (LAD) ≥3.8cm, left atrial area (LAA) ≥20cm2, left atrial volume index (LAVI) >30 mL/m2, left ventricular mass index (LVMI) ≥115 g/m2 (♂)/ 95 g/m2 (♀), septal thickness or posterior wall thickness ≥1.1 cm

  • n-terminal prohormone B-type natriuretic peptide (NT-proBNP) ≥300 pg/mL (BNP ≥100 pg/mL) in sinus rhythm and patient does not have an ongoing diagnosis of paroxysmal atrial fibrillation or NT-proBNP ≥900 pg/mL (BNP ≥300 pg/mL) in atrial fibrillation (or if atrial fibrillation status is unknown or if patient has an ongoing diagnosis of paroxysmal atrial fibrillation) for participants obtained at the following time:

    • Within 90 days prior to randomization if patient had been hospitalized for heart failure (HF) requiring initiation or change in HF therapy or if patient had an urgent visit for HF requiring intravenous (IV) diuretic therapy, both within 90 days prior to randomization OR
    • Within 30 days prior to randomization if patient has not been hospitalized for HF nor had an urgent HF visit within the past 90 days.
  • Women of childbearing potential can only be included in the study if a pregnancy test is negative at screening and baseline and if they agree to use adequate contraception which is consistent with local regulations regarding the methods for contraception for those participating in clinical trials.

Exclusion Criteria:

  • Estimated glomerular filtration rate (eGFR) <25 mL/min/1.73 m² at either screening or randomization visit.
  • Serum/plasma potassium >5.0 mmol/L at either screening or randomization visit.
  • Acute inflammatory heart disease, e.g. acute myocarditis, within 90 days prior to randomization
  • Myocardial infarction or any event which could have reduced the ejection fraction within 90 days prior to randomization
  • Coronary artery bypass graft surgery in the 90 days prior to randomization
  • Percutaneous coronary intervention in the 30 days prior to randomization
  • Stroke or transient ischemic cerebral attack within 90 days prior to randomization
  • Probable alternative cause of participants' HF symptoms that in the opinion of the investigator primarily accounts for patient's dyspnea such as significant pulmonary disease, anemia or obesity. Specifically, patients with the below are excluded: Severe pulmonary disease requiring home oxygen, or chronic oral steroid therapy, History of primary pulmonary arterial hypertension, Hemoglobin <10 g/dl, Valvular heart disease considered by the investigator to be clinically significant, Body Mass Index (BMI) >50 kg/m2 at screening
  • Systolic blood pressure(SBP) ≥160 mmHg if not on treatment with ≥3 blood pressure lowering medications or ≥180 mmHg irrespective of treatments, on 2 consecutive measurements at least 2-minute apart, at screening or at randomization.
  • Concomitant systemic therapy with potent cytochrome P450 isoenzyme 3A4 (CYP3A4) inhibitors (e.g. itraconazole, ritonavir, indinavir, cobicistat, clarithromycin) or moderate or potent CYP3A4 inducers, that cannot be discontinued 7 days prior to randomization and for the duration of the treatment period.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Quadruple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Arm 1_BAY94-8862
Adult patients receive BAY94-8862
Drug: Finerenone (BAY94-8862)

For participants with an eGFR ≤60 mL/min/1.73 m^2: Starting dose is 10 mg OD and maximum dose 20 mg OD.

For participants with an eGFR >60 mL/min/1.73 m^2: Starting dose is 20 mg OD and maximum dose 40 mg OD. Finerenone is administered orally as immediate release tablets.
Placebo Comparator: Arm 2_Placebo
Adult patients receive placebo
Other: Placebo
Placebo tablets matching BAY94-8862 are administered orally.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Occurrence of the Composite Endpoint of Cardiovascular Death and Total (First and Recurrent) Heart Failure Events
Time Frame: From randomization up until the end of study, with an average study duration of 32 months
Number of composite endpoint events of cardiovascular death and total (first and recurrent) heart failure (HF) events (hospitalization for heart failure or urgent HF visit) in HF patients.
From randomization up until the end of study, with an average study duration of 32 months
Occurrence of the Composite Endpoint of Cardiovascular Death and Total (First and Recurrent) Heart Failure Events
Time Frame: From randomization up until the end of study, with an average study duration of 32 months
Number of participants with composite endpoint events of cardiovascular death and total (first and recurrent) heart failure (HF) events (hospitalization for heart failure or urgent HF visit) in HF patients.
From randomization up until the end of study, with an average study duration of 32 months

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Occurrence of Total (First and Recurrent) Heart Failure Events
Time Frame: From randomization up until the end of study, with an average study duration of 32 months
Number of total (first and recurrent) heart failure events.
From randomization up until the end of study, with an average study duration of 32 months
Occurrence of Total (First and Recurrent) Heart Failure Events
Time Frame: From randomization up until the end of study, with an average study duration of 32 months
Number of participants with total (first and recurrent) heart failure events.
From randomization up until the end of study, with an average study duration of 32 months
Change From Baseline in Total Symptom Score (TSS) of the Kansas City Cardiomyopathy Questionnaire (KCCQ)
Time Frame: From baseline to Month 6, 9 and 12

The Kansas City Cardiomyopathy Questionnaire Total Symptom Score (KCCQ-TSS) is ranged from 0 to 100. A higher score (closer to 100) reflects fewer symptoms, indicating better heart failure symptom status.

For the change from baseline the combined and averaged result across the entire time frame is reported.
From baseline to Month 6, 9 and 12
Proportion of Participants Who Showed Improvement in NHYA Class
Time Frame: from baseline to Month 12
The New York Heart Association (NYHA) Functional Classification is a simple scale that classifies patients with heart failure based on the severity of their symptoms and how those symptoms affect their physical activity, which ranges from Class I to Class IV, a lower class number is indicative of a better condition. A patient was considered as having improved in NYHA class, if the NYHA class at Month 12 is at least one category improved compared to the baseline visit.
from baseline to Month 12
First Occurrence of Renal Composite Events
Time Frame: From randomization up to end of study visit, with an average study duration of 32 months
Number of participants with renal composite events encompassing the components sustained decrease in eGFR ≥50% relative to baseline over at least 4 weeks, sustained eGFR decline to <15 mL/min/1.73 m2 over at least 4 weeks, initiation of chronic dialysis and renal transplantation.
From randomization up to end of study visit, with an average study duration of 32 months
Occurence of All-cause Mortality (Full Analysis Set)
Time Frame: From randomization until end of study, with an average of 32 months
Number of participants with death due to any cause were reported as descriptive result. Number of participants with outcome death reported here includes deaths occurred after randomization until the end of the study visit. Deaths after end of study visit are not included in this table.
From randomization until end of study, with an average of 32 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Bayer

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

September 14, 2020

Primary Completion (Actual)

May 15, 2024

Study Completion (Actual)

June 14, 2024

Study Registration Dates

First Submitted

June 15, 2020

First Submitted That Met QC Criteria

June 15, 2020

First Posted (Actual)

June 17, 2020

Study Record Updates

Last Update Posted (Estimated)

August 26, 2025

Last Update Submitted That Met QC Criteria

August 25, 2025

Last Verified

August 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 20103
  • 2020-000306-29 (EudraCT Number)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

Availability of this study's data will later be determined according to Bayer's commitment to the EFPIA/PhRMA "Principles for responsible clinical trial data sharing". This pertains to scope, timepoint and process of data access. As such, Bayer commits to sharing upon request from qualified researchers patient-level clinical trial data, study-level clinical trial data, and protocols from clinical trials in patients for medicines and indications approved in the US and EU as necessary for conducting legitimate research. This applies to data on new medicines and indications that have been approved by the EU and US regulatory agencies on or after January 01, 2014.

Interested researchers can use www.vivli.org to request access to anonymized patient-level data and supporting documents from clinical studies to conduct research. Information on the Bayer criteria for listing studies and other relevant information is provided in the member section of the portal.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Heart Failure

Clinical Trials on Finerenone (BAY94-8862)

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Lithuania

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

Subscribe