Emp-Activity: Empagliflozin Functional Capacity

August 21, 2025 updated by: Boehringer Ingelheim

Empagliflozin Functional Capacity - Non-Interventional Study

This is a multinational non-interventional study based on newly collected data to assess demographics, disease, and treatment pattern of patients with chronic Heart Failure (HF) in a two-cohort design: one cohort will receive first prescription of empagliflozin as routine therapy for HF, the other cohort will receive HF therapy with drugs with another mechanism of action. Treatment of HF according to routine practice is determined by the physician independent of the participation of the patient in this non-interventional study.

Study Overview

Status

Completed

Conditions

Heart Failure

Intervention / Treatment

Drug: Empagliflozin

Study Type

Observational

Enrollment (Actual)

3431

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Bulgaria
- - Burgas, Bulgaria, 8000
    - Dr. Mircheva
  - Haskovo, Bulgaria, 6304
    - Dr. Yordanov
  - Kardzhali, Bulgaria, 6600
    - MBAL Atanas Dafovski, Kardzhali
  - Kyustendil, Bulgaria, 2501
    - Dr. Krasteva
  - Lovech, Bulgaria, 5500
    - Dr. Todorov
  - Lovech, Bulgaria, 5500
    - Dr. Tsoneva
  - Parvomay, Bulgaria, 4270
    - Dr. Pavlov
  - Pazardzhik, Bulgaria, 4400
    - Medical Center, Pazardjik
  - Pernik, Bulgaria, 2300
    - Dr. Stankova
  - Pleven, Bulgaria, 5800
    - assoc.prof. Gospodinov
  - Pleven, Bulgaria, 5800
    - dr. Kostadinovska
  - Pleven, Bulgaria, 5800
    - prof.Tisheva
  - Plovdiv, Bulgaria, 4001
    - Dr. Mekenian
  - Plovdiv, Bulgaria, 4002
    - Dr. Ilchev
  - Plovdiv, Bulgaria, 4018
    - Dr. Hairabedian
  - Plovdiv, Bulgaria, 4020
    - Dr. Filipov
  - Sliven, Bulgaria, 8800
    - MBAL Sliven, Dr. Bletsova
  - Sofia, Bulgaria, 1000
    - Dr. Pancheva
  - Sofia, Bulgaria, 1000
    - prof. Velchev
  - Sofia, Bulgaria, 1202
    - dr. Georgieva
  - Sofia, Bulgaria, 1202
    - dr. Karchinova
  - Sofia, Bulgaria, 1202
    - prof.Vitlianova
  - Sofia, Bulgaria, 1233
    - dr. Petrusheva
  - Sofia, Bulgaria, 1407
    - dr. Garvanski
  - Sofia, Bulgaria, 1431
    - Dr. Naidenova
  - Sofia, Bulgaria, 1431
    - Dr. Varnaliiska
  - Sofia, Bulgaria, 1431
    - prof. Karamfiloff
  - Sofia, Bulgaria, 1784
    - Dr. Nossikov
  - Stara Zagora, Bulgaria, 6004
    - Dr. Gospodinov
  - Targovishte, Bulgaria, 7700
    - Dr. Trendafilova
  - Varna, Bulgaria, 9000
    - dr. Belcheva
  - Varna, Bulgaria, 9003
    - dr. Mancheva
  - Varna, Bulgaria, 9010
    - dr. Gyuzelev
  - Yambol, Bulgaria, 8600
    - Dr. Petrova
  - Yambol, Bulgaria, 8600
    - Dr. Toneva-Zhelaeva
Czechia
- - Brno, Czechia, 602 00
    - Fakultní nemocnice u sv. Anny v Brne
  - Brno, Czechia, 603 00
    - MUDr. Karel Kameník s.r.o.
  - Brno, Czechia, 61600
    - MUDr. Libor Nechvatal s.r.o.
  - Brno, Czechia, 62700
    - Zdravá srdce s.r.o.
  - Brno - Královo Pole, Czechia, 61200
    - Kardiologická ambulance Brno, s.r.o.
  - Broumov, Czechia, 55001
    - EDUMED s.r.o. - Dr. Nováková
  - Broumov, Czechia, 55001
    - EDUMED s.r.o. - Dr. Polášková
  - Broumov, Czechia, 55001
    - EDUMED s.r.o. - Dr. Švarcová
  - Broumov, Czechia, 55001
    - EDUMED s.r.o.
  - Bílovec, Czechia, 743 01
    - MUDr. Hana Burianova
  - Frýdek-Místek, Czechia, 73801
    - CorMedico s.r.o.
  - Havířov, Czechia, 73601
    - DIKa centrum s.r.o.
  - Havířov, Czechia, 73601
    - Lékařský servis, a.s.
  - Hlučín, Czechia, 748 01
    - Kardio Pudich s.r.o.
  - Hradec Králové, Czechia, 50011
    - ProKardio HK, s.r.o.
  - Jihlava, Czechia, 58633
    - Nemocnice Jihlava - Kardiologické oddělení
  - Kolín, Czechia, 2802
    - Oblastní nemocnice Kolín, a.s. nemocnice Středočeského kraje
  - Louny, Czechia, 440 01
    - KardioBusak s.r.o.
  - Most, Czechia, 43401
    - Kardiomost s.r.o.
  - Nový Jičín, Czechia, 74101
    - Nemocnice AGEL Nový Jičín, a.s.
  - Olomouc, Czechia, 77900
    - Kardiologická ambulance Olomouc
  - Ostrava, Czechia, 70030
    - Nemocnice AGEL Ostrava-Vítkovice a.s. - Kardiologická ambulance
  - Ostrava, Czechia, 70200
    - Kardiologická ambulance Mammed
  - Ostrava, Czechia, 70200
    - OVAKARD s.r.o.
  - Ostrava, Czechia, 71900
    - Poliklinika Nová Huť
  - Ostrava - Poruba, Czechia, 708 52
    - Fakultni Nemocnice Ostrava
  - Prague, Czechia, 150 30
    - Nemocnice na Homolce
  - Prague, Czechia, 128 00
    - Všeobecná fakultní nemocnice v Praze
  - Prague, Czechia, 120 00
    - Kardiologie Vinohrady s.r.o.
  - Prague, Czechia, 12000
    - Kardiologie prof. Táborský s.r.o.
  - Prague, Czechia, 140 00
    - Medicon a.s.
  - Prague, Czechia, 15600
    - Clinical Trials Service s.r.o.
  - Prostějov, Czechia, 79604
    - ROcardia s.r.o.
  - Prostřední Suchá, Czechia, 73564
    - Galenica Medical s.r.o.
  - Trutnov, Czechia, 54101
    - Kardiologicka ambulance MUDr. Ferkl s.r.o.
  - Tábor, Czechia, 39003
    - Všeobecná interní ambulance s.r.o.
  - Třinec Podlesí, Czechia, 73961
    - Nemocnice AGEL Trinec-Podlesi a.s.
  - Vizovice, Czechia, 76312
    - Lunacor s.r.o.
  - Zlín, Czechia, 76275
    - Krajska nemocnice T. Bati, a.s.
  - Český Krumlov, Czechia, 38101
    - Kardiologická ambulance Český krumlov
  - Šumperk, Czechia, 78701
    - KARDIO GRÉZL, s.r.o.
Hungary
- - Balatonfüred, Hungary, 8230
    - Állami Szívkorhaz
  - Budapest, Hungary, 1096
    - Gottsegen György National Cardiovascular Center
  - Budapest, Hungary, 1122
    - Heart and Vascular Centre, Semmelweis University
  - Budapest, Hungary, 1133
    - Sante Cons Bt.
  - Debrecen, Hungary, 4032
    - DE Klinikai Központ Kardiológia és Szívsebészet
  - Dombóvár, Hungary, 7200
    - Dombóvári Szent Lukács Kórház
  - Dunavarsány, Hungary, 2336
    - Lahynara Bt
  - Eger, Hungary, 3300
    - Kardiológia Magánrendelő
  - Mohács, Hungary, 7700
    - Mohacsi Korhaz
  - Pécs, Hungary, 7624
    - University of Pecs
  - Pécs, Hungary, 7623
    - Coromed-Smo
  - Sopron, Hungary, 9400
    - Soproni Erzsébet Oktató Kórház
  - Szeged, Hungary, 6726
    - Újszeged Egészségközpont
Poland
- - Bialystok, Poland, 15-028
    - ECHOKardio Poradnia Kardiologiczna
  - Bialystok, Poland, 15-276
    - Klinika Kardiologii Uniwersyteckiego Szpitala Klinicznego w Białymstoku
  - Bialystok, Poland, 15-546
    - Kardiologiczna Praktyka Lekarska Anna Tomaszuk-Kazberuk
  - Bialystok, Poland, 15-875
    - Podlaski Ośrodek Kardiologii
  - Brzozów, Poland, 36-200
    - Specjalistyczna Praktyka Lekarska Marek Styczkiewicz
  - Bydgoszcz, Poland, 85-088
    - BlueMed - Centrum Medyczne
  - Bydgoszcz, Poland, 85-095
    - Centrum Kardiologii Paweł Grzelakowski
  - Bydgoszcz, Poland, 85-314
    - Centrum Medyczne A i D Nowak sj
  - Bydgoszcz, Poland, 85-791
    - Indywidualna Specjalistyczna Praktyka Lekarska Tomasz Ługowski
  - Bydgoszcz, Poland, 85-796
    - Specjalistyczna Praktyka Lekarska Grzegorz Grześk
  - Bytom, Poland, 41-902
    - Indywidualna Specjalistyczna Praktyka Lekarska Jolanta Nowak
  - Chorozow, Poland, 41500
    - Specjalistyczna Praktyka Lekarska Agata Fenger
  - Cieszyn, Poland, 43-400
    - Med. - Zone sp zoo
  - Czeladź, Poland, 41250
    - Specjalistyczna Praktyka Lekarska lek.n.med.Lucyna Góras-Hetmańczyk
  - Częstochowa, Poland, 42-202
    - Gabinet Kardiologiczny - Jacek Jafra
  - Częstochowa, Poland, 42-202
    - Prywatna Praktyka Lekarska Artur Dekiela
  - Dąbrowa Górnicza, Poland, 41-300
    - Specjalistyczna Praktyka Lekarska Magdalena Miczko
  - Gdynia, Poland, 81-395
    - ISPL Małgorzata Dobrowolska Gabinet Tendo
  - Gliwice, Poland, 44-100
    - Specjalistyczna Praktyka Lekarska Wojciech Czapla
  - Gmina Jędrzejów, Poland, 28-300
    - Dorota Adamczyk-Kot NZOZ-KARDIO
  - Gmina Świebodzin, Poland, 66-200
    - Lekarze na Dworskiej
  - Grodzisk Mazowiecki, Poland, 05-825
    - Indywidualna Praktyka Lekarska Tomasz Zieliński
  - Grójec, Poland, 05-600
    - Przychodnia Lekarska Zdrowy Miś
  - Głogów, Poland, 67-200
    - Miedziowe Centrum Zdrowia s.a.
  - Głogów Małopolski, Poland, 36-060
    - Centrum Medyczne NIWA
  - Inowrocław, Poland, 88-100
    - Indywidualna Praktyka Lekarska Piotr Tokarczyk
  - Iwanowice Włościańskie, Poland, 32-095
    - Familia Medicina Sp. z o.o.
  - Jastrzębie Zdrój, Poland, 44-330
    - Specjalistyczna Praktyka Lekarska Urszula Winiarska-Waluś
  - Jasło, Poland, 38-200
    - Specjalistyczna Praktyka Lekarska Jarosław Paździerz
  - Kamień, Poland, 36-053
    - Centrum Medyczne Kinesis
  - Katowice, Poland, 40-645
    - Praktyka Lekarska Wojciech Kwaśniewski
  - Katowice, Poland, ul. Drozdów 26
    - Prywatna Przychodnia Specjalistyczna Drozd Zbigniew Gąsior
  - Kielce, Poland, 25-020
    - CUM PromontMed
  - Konin, Poland, 62-500
    - Arsmedica Specjalistyczna Praktyka Lekarska lek.med. Krzysztof Czerniejewski
  - Konin, Poland, 62-500
    - Prywatny Gabinet Kardiologiczny lek. med. Sławomir Kępski
  - Konin, Poland, 62-500
    - Specjalistyczna Praktyka Lekarska Paweł Michalski
  - Koszalin, Poland, 75-402
    - Uromed Sp Zoo
  - Koszalin, Poland, 75-604
    - Poliklinika MSWiA/Indywidualna Specjalistyczna Praktyka Lekarska Krzysztof Jarząbek
  - Koźminek, Poland, 62-840
    - Indywidualna Praktyka Lekarska Krzysztof Maślak
  - Krakow, Poland, 31-070
    - Centrum Medyczne Dietla 19 Sp. z o.o.
  - Krakow, Poland, 31-101
    - Centrum Twojego Zdrowia
  - Krakow, Poland, 31-216
    - Specjalistyczna Praktyka Lekarska "Kardiolek" Dr med. Piotr Wilkołek
  - Krakow, Poland, 31-513
    - CM Oficerskie
  - Krakow, Poland, 31-826
    - Poradnia Kardiologiczna, Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie
  - Kranse, Poland, 36-007
    - Prywatny Gabinet Kardiologiczny Dr n.med Janusz Bąk
  - Krościenko Wyżne, Poland, 38-422
    - Centrum Medyczne Dębina
  - Legnica, Poland, 59-220
    - Beata Mikłaszewicz&Dariusz Dąbrowski Cardiamed S.J.
  - Legnica, Poland, 59-220
    - NZOZ DUOMED S.C. Poradnia Kardiologiczna
  - Libiąż, Poland, 32-590
    - Prywatny Specjalistyczny Gabinet Kardiologiczno-Internistyczny
  - Lodz, Poland, 90-302
    - Santa Sp. z o.o.
  - Lodz, Poland, 91-002
    - Nzoz Salusmed
  - Lublin, Poland, 20-053
    - Kardiologiczna Praktyka Lekarska Wojciech Kula
  - Lublin, Poland, 20-143
    - NZOZ Sanus Jacek Madej Poradnia kardiologiczna
  - Lublin, Poland, 20-143
    - NZOZ Sanus Jacek Madej
  - Lublin, Poland, 20-400
    - Provivo Specjalistyczne Centrum Medyczne
  - Lublin, Poland, 59-300
    - Indywidualna Specjalistyczna Praktyka Lekarska - Renata Leniec
  - Mikołów, Poland, 43-190
    - Niepubliczny Zakład Opieki Zdrowotnej Specjalistyczne Gabinety lekarskie
  - Mirków, Poland, 55-095
    - Gabinet Lekarski Kardiologiczny
  - Modliszewice, Poland, 26-200
    - Prywatne Usługi Medyczne Jacek Morka
  - Moszczenica, Poland, 97-310
    - Indywidualna Specjalistyczna PraktyKa Lekarska-Piotr Utz
  - Nowe Miasto nad Pilicą, Poland, 26-420
    - Gabinet Lekarski Ewa Burchard
  - Nowy Tomyśl, Poland, 64-300
    - Medyczne Centrum Zdrovita
  - Oleśnica, Poland, 56-400
    - Oleśnica Prywatna Praktyka Lekarska
  - Ostrów Wielkopolski, Poland, 63-400
    - SZOZ Jantar Sp. z o.o. Poradnia Lekarzy Specjalistów
  - Oświęcim, Poland, 32-600
    - GVM CARINT Oświęcim
  - Piasek, Poland, 43-211
    - Specjalistyczna Praktyka Lekarska Rafał Nowak
  - Piotrkow Trybunalski, Poland, 97-300
    - Specjalistyczna Praktyka Lekarska Andrzej Bęben
  - Poznan, Poland, 60-461
    - Indywidualna Specjalistyczna Praktyka Lekarska Andrzej Bolewski
  - Przemyśl, Poland, 37-700
    - Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu
  - Przeworsk, Poland, 37-200
    - Leszek Kaminski Specjalistyczny Gabinet Lekarski
  - Pszczyna, Poland, 43-200
    - Praktyka Lekarska Katarzyna Czarnecka
  - Puławy, Poland, 24-100
    - PCK - Puławskie Centrum Kardiologiczne Przychodnia Specjalistyczna
  - Puławy, Poland, 24-100
    - Poradnia Kardiologiczna SPZOZ Pulawy
  - Płock, Poland, 09-402
    - Indywidualna Specjalistyczna Praktyka Lekarska Maciej Strawczyński
  - Radom, Poland, 26-600
    - Indywidualna Specjalistyczna Praktyka Lekarska Magdalena Poterala
  - Radom, Poland, 26-600
    - Poradnia Kardioogiczna Zegara Słonecznego
  - Radzionków, Poland, 41-922
    - Specjalistyczna Praktyka Lekarska Radzionków
  - Rybnik, Poland, 44-203
    - Indywidualna Specjalistyczna Praktyka Lekarska dr n. med. Alicja Gałuszka-Bilińska
  - Rybnik, Poland, 44-217
    - Specjalistyczna Praktyka Lekarska Wiesława Faberska-Blicharska
  - Rzeszów, Poland, 35-006
    - Centrum Medyczne Sabamed
  - Rzeszów, Poland, 35-055
    - Prywatny Gabinet Kardiologiczny dr n.med Janusz Romanek
  - Sanok, Poland, 38-500
    - My Life Centrum chorób serca
  - Siedlce, Poland, 08-110
    - Monika Kujawiak Prywatna Praktyka Lekarska
  - Siedlce, Poland, 08-110
    - Prywatny Gabinet Lekarski Hanna Wilk-Manowiec
  - Siemianowice Śląskie, Poland, 41-106
    - Indywidualna praktyka lekarska Artur Marcinkiewicz
  - Skierniewice, Poland, 96-100
    - Asnyka 78d Gabinety Lekarskie
  - Sosnowiec, Poland, 41-200
    - Specjalistyczna Praktyka Lekarska Maciej Kaźmierski
  - Sosnowiec, Poland, 41-200
    - Specjalistyczna Praktyka Lekarska Marek Kondys
  - Stalowa Wola, Poland, 37-450
    - Powiatowy Szpital Specjalistyczny w Stalowej Woli
  - Szczecin, Poland, 70-341
    - Centrum Medyczne VITA
  - Szczecin, Poland, 71-790
    - Specjalistyczna Praktyka Lekarska Tomasz Urbanik
  - Szczecin, Poland, 71-804
    - ISPL Anna Bis
  - Szczecinek, Poland, 78-400
    - Szpital w Szczecinku
  - Szczytniki, Poland, 62-023
    - Gabinet Lekarski Weronika Greberska
  - Tarnowskie Góry, Poland, 42-606
    - Leomed Centrum Medyczne
  - Tarnów, Poland, 33-100
    - Specjalistyczna Praktyka Lekarska Paweł Kocik
  - Torun, Poland, 87-100
    - Prywatna Praktyka Lekarska na wezwanie Mirosław Marciniak
  - Tychy, Poland, 43-100
    - Indywidualna Specjalistyczna Praktyka Lekarska - Witold Orszulak
  - Tychy, Poland, 43100
    - Urszula Urbanowicz Specjalistyczna Praktyka Lekarska
  - Warsaw, Poland, 02-496
    - SERCE S.C. Przychodnia Lekarzy Specjalistów
  - Warsaw, Poland, 02-991
    - Klinika 37 Centrum Kardiologii Płowiecka
  - Warsaw, Poland, 04-188
    - Prywatny Gabinet Lekarski Bożena Norwa-Otto
  - Wawrzeńczyce, Poland, 32-125
    - Gabinet Lekarski lek med. Robert Włodarczyk
  - Wałbrzych, Poland, 58-302
    - Centrum Medyczne Nowe Miasto
  - Włocławek, Poland, 87-800
    - Specjalistyczny Gabinet Lekarski Łukasz Graczykowski
  - Zabrze, Poland, 10444
    - Specjalistyczna Prajtyka Lekarska Grażyna Glanowska
  - Zabrze, Poland, 41-800
    - Gabinet Prywatnej Praktyki Lekarskiej Kard.-Int . Dr n.med. Brygida Przywara-Chowaniec
  - Zamość, Poland, 22-400
    - Ns Zoz Kardiologia Sp. Z.O.O.
  - Zielona Góra, Poland, 65-001
    - ALDEMED Centrum Medyczne
  - Łańcut, Poland, 37-100
    - Poradnia Kardiologiczna Centrum Medyczne w Łańcucie
  - Łuków, Poland, 21-400
    - Kardiologiczno - Internistyczny Gabinet Lekarski Skrzyński Andrzej
  - Łęczna, Poland, 21-010
    - SP ZOZ Łęczna
  - Ścinawa, Poland, 59-330
    - Specjalistyczna Praktyka Lekarska Kamila Stembalska
  - Żary, Poland, 68-200
    - Gabinety Lekarskie JM Kulczyccy
  - Żyrardów, Poland, 96-300
    - Prywatna Praktyka Lekarska Anna Chudoba
Romania
- - Alba Iulia, Romania, 510137
    - Miclea Ioana - Mariana MEDIC SPECIALIST CARDIOLOG
  - Arad, Romania, 310009
    - Dr. Morar Mihnea-Dragoscabinet Medical Individual - Specialist Cardiologie
  - Arad, Romania, 310182
    - Dr. Pop-Moldovan Adina-Ligia - Medicina Interna - Cardiologie
  - Bacau, Romania, 600037
    - CMI Iosipescu Laura Cristina
  - Bacau, Romania, 600204
    - Cardio Animus SRL
  - Baia Mare, Romania, 430076
    - CMI - Centrul medical Diacord
  - Baia Mare, Romania, 430123
    - Mercea Corina-Delia - Medic
  - Botoșani, Romania, 710095
    - Ambrinomed SRL
  - Brasov, Romania, 500326
    - Cardioland SRL
  - Brasov, Romania, RO-500188
    - Rus V. Horatiu - Cabinet Medical Individual de Cardiologie
  - Bucharest, Romania, 010991
    - S.C. Ilro Medical S.R.L
  - Bucharest, Romania, 011026
    - PFA Balahura Cristian
  - Bucharest, Romania, 011258
    - Dr. Danet Ruxandra - Medic Cardiologie
  - Bucharest, Romania, 011925
    - Dr. Bogdan Stefan Nicolae
  - Bucharest, Romania, 012052
    - Cardiocare Center SRL
  - Bucharest, Romania, 012082
    - Cordmedica SRL
  - Bucharest, Romania, 020281
    - Dr. Serban Irina-Ruxandra - MEDIC PRIMAR CARDIOLOGIE
  - Bucharest, Romania, 020281
    - Urocard Plus Srl
  - Bucharest, Romania, 020501
    - Medi Pro Consult SRL
  - Bucharest, Romania, 021705
    - Cmi Dr Georgescu Dragos
  - Bucharest, Romania, 021967
    - Dr. Geavlete Dana-Oliviana - Activitate Medicala
  - Bucharest, Romania, 030915
    - Mihaila I. Sorina - Medic Pfi
  - Bucharest, Romania, 040343
    - S.C. Cardiomedical Team Pro S.R.L.
  - Bucharest, Romania, 060926
    - Dumitrescu Silviu-Ionel Persoana Fizica Autorizata
  - Bucharest, Romania, 061192
    - Mihalcea Janina-Diana Medic Specialist Cardiologie
  - Bucharest, Romania, 061304
    - Patrascu R. Natalia - Medic Specialist Medicina Interna
  - Bucharest, Romania, 061406
    - Popescu I. Ileana Nicoleta Medic specialist cardiologie
  - Bucharest, Romania, 062282
    - CMI Dr. Parsa Motlagh Babak
  - Bucharest, Romania, 070000
    - Magister Research SRL
  - Bucharest, Romania, RO-011038
    - Dr. Lungeanu-Juravle Laura-Activitate Medicala
  - Buzău, Romania, 120195
    - Cardio Clinique NCS SRL
  - Buzău, Romania, 120203
    - Medcon SRL
  - Buzău, Romania, 120279
    - Medicard SRL
  - Ciurea, Romania, RO-707085
    - Angioplast Medical srl
  - Cluj-Napoca, Romania, 400347
    - CMI Diaconescu Iulia Dana
  - Cluj-Napoca, Romania, 400347
    - Mediprax Centrum Cluj Napoca
  - Cluj-Napoca, Romania, 400347
    - SC Adisan SRL
  - Cluj-Napoca, Romania, 400347
    - Sc Medicardio Andreea Srl
  - Cluj-Napoca, Romania, 400349
    - Cardiotreat SRL
  - Cluj-Napoca, Romania, 400394
    - SC Clujana Medica Srl
  - Cluj-Napoca, Romania, 400441
    - PFA Comsa M.Dan-Horatiu
  - Cluj-Napoca, Romania, 400479
    - Cabinet Cardiohealt Srl
  - Cluj-Napoca, Romania, 400535
    - SC Cardioprotect MED SRL
  - Cluj-Napoca, Romania, RO-400480
    - Sc Dentcor Srl
  - Com Mosoaia, Romania, 117512
    - Cardio World Health
  - Constanța, Romania, 610219
    - Cardio Manea Adelina SRL
  - Constanța, Romania, 900002
    - Endodiahealth Srl
  - Constanța, Romania, 900168
    - Dr. Maxim George Razvan - Activitate Medicala
  - Constanța, Romania, 900519
    - CMI Dr Ilie Ivona Valeria
  - Constanța, Romania, 900615
    - Asclepios Medicalhealth SRL
  - Craiova, Romania, 200085
    - Sc Daxiela Impex Srl
  - Craiova, Romania, 200323
    - Hortopan Med SRL
  - Craiova, Romania, 200383
    - Neurocord Medical SRL
  - Craiova, Romania, 200470
    - Vesalius Medical S.R.L
  - Craiova, Romania, 200519
    - Cabinet Medical Individual - Dr. Popescu Monica
  - Craiova, Romania, RO-200692
    - SC A&C Medical Prime SRL
  - Curtea de Argeş, Romania, 115300
    - S & R Cardiobalance Srl
  - Deva, Romania, 330011
    - Cardiolife
  - Drobeta-Turnu Severin, Romania, 220004
    - Bendl H. Laura Elena - Cabinet Medical Individual Plus Clinic
  - Galati, Romania, 800217
    - SC Maycor SRL
  - Galati, Romania, 800584
    - CMI Dr. Chiscaneanu Teodor
  - Gheorghieni, Romania, 535500
    - Cardiomedplus SRL
  - Iași, Romania, 700111
    - Procardia Serv-Med 2009 SRL srl
  - Iași, Romania, 700260
    - Sc Cardiocare Clinic Srl
  - Iași, Romania, 700282
    - Sc Cardiortomed Srl
  - Iași, Romania, 700451
    - Medical Cardio Anghel SRL
  - Iași, Romania, 700688
    - Niculescu G. Ana Irina - Medic colaborator
  - Iași, Romania, 700732
    - SC Cardiomed SRL Iasi
  - Miercurea-Ciuc, Romania, 530112
    - Cardioszakacs Srl, Cui 34404518
  - Odorheiu Secuiesc, Romania, 535600
    - Polimed Center SRL, CUI 26072639
  - Oradea, Romania, 410009
    - CMI Dr. Rotariu Dragos
  - Oradea, Romania, 410027
    - CMI Societatea civila Magheru&Magheru
  - Oradea, Romania, 410169
    - CMI Cardiomed SRL
  - Oradea, Romania, 410388
    - PFA Dr. Ardelean Adriana Ioana
  - Oradea, Romania, 410473
    - Dradiand SRL
  - Oradea, Romania, 410474
    - Sc Adriacard Srl
  - Ostratu, Romania, 012052
    - Simed Concept SRL
  - Piatra Neamţ, Romania, 610065
    - Andries I. Elena - Medic Primar Cardiologie Si Medic Specialist Mi
  - Piatra Neamţ, Romania, 610078
    - Cardiomed Alexandrescu Srl-D
  - Piatra Neamţ, Romania, 610150
    - Dr. Corcoz Cardiologie SRL
  - Piteşti, Romania, 110003
    - Davisof San Srl
  - Piteşti, Romania, 110074
    - Clinica Cardiologie Dr Stanciu Viorel
  - Piteşti, Romania, 110172
    - Sc Procordia Concept Srl
  - Ploieşti, Romania, 100562
    - Cavi Clinique SRL
  - Râmnicu Vâlcea, Romania, 240022
    - SC Cardiologie Dr. Cristina Radoi SRL
  - Râmnicu Vâlcea, Romania, 240282
    - Sc Lidermed Plus Srl
  - Râmnicu Vâlcea, Romania, 240284
    - Sc Incarmed Srl
  - Sat Rosu, Comuna Chiajna, Romania, 077041
    - Munteanu Alice-Elena - Medic Cardiolog
  - Scheia, Romania, 720282
    - Voineag Olivia Medic Colaborator
  - Sfântu Gheorghe, Romania, 520068
    - SC Endocordis SRL
  - Suceava, Romania, 720067
    - Rusu N. Ramona Iulia Medic Primar Cardiologie
  - Sânpetru, Romania, 507190
    - Cardio Stim Center SRL
  - Săcele, Romania, 505600
    - Gx.Hatconsulting Srl
  - Tifgu Mures, Romania, 540281
    - Diaconu Diana - Medic Cif 31885867
  - Timișoara, Romania, 300172
    - Cardiomed Health SRL
  - Timișoara, Romania, 300230
    - Mornos Cristian Medic Independent
  - Timișoara, Romania, 300244
    - Cardio Suport SRL
  - Timișoara, Romania, 300362
    - Medicalife Tim SRL
  - Timișoara, Romania, 300369
    - Cardio - DRS S.R.L
  - Timișoara, Romania, 300480
    - Policlinica Dr. Tudoran
  - Târgu Mureş, Romania, 540095
    - German Sallo Marta - Medic primar cardiolog, CIF 35699735
  - Târgu Mureş, Romania, RO-540496
    - CMI Tatar A. Maria Cristina, CUI 19814204
  - Valea Adâncă, Romania, 700732
    - Croitoru G Rodica Medic Colaborator
  - Zalău, Romania, 450103
    - CMI Demle S. Adriana-Cristina
  - Zarnesti, Romania, 505800
    - Dr. Dragos Lupu - Medic Specialist Cardiolog
  - Şelimbăr, Romania, 557260
    - Batar D. Sergiu Constantin
Switzerland
- - Basel, Switzerland, 4051
    - Universitatsspital Basel
  - Bern, Switzerland, 3006
    - Spital Sonnenhof
  - Bern, Switzerland, 3012
    - Engeried-Spital (Bern)
  - Biel, Switzerland, 2501
    - Spitalzentrum Biel
  - Carouge, Switzerland, 1227
    - Hôpital de la Tour
  - Courrendlin, Switzerland, 2830
    - Cardiomed - Jura
  - Delémont, Switzerland, 2800
    - Centre de Cardiologie
  - Frauenfeld, Switzerland, 8500
    - Schlossberg Ärztezentrum
  - Geneva, Switzerland, 1211
    - Hôpitaux Universitaires de Genève
  - Geneva, Switzerland, 1205
    - Hôpitaux Universitaires de Genève
  - Lachen, Switzerland, 8853
    - Spital Lachen AG
  - Lausanne, Switzerland, 1011
    - CHUV-Centre hospitalier universitaire vaudois
  - Lucerne, Switzerland, 6004
    - Luzerner Kantonsspital
  - Lucerne, Switzerland, 6006
    - Herzzentrum Hirslanden Zentralschweiz
  - Morges, Switzerland, 1110
    - Hôpital de Morges
  - Neuchâtel, Switzerland, 2000
    - Dr. med. Eleni Goulouti
  - Olten, Switzerland, 4600
    - Kantonsspital Olten
  - Regensdorf, Switzerland, 8105
    - Herzpraxis Regensdorf
  - Sankt Gallen, Switzerland, 9000
    - Herzpraxis Sankt Gallen
  - Sarnen, Switzerland, 6060
    - Kantonsspital Obwalden
  - Seewis, Switzerland, 7212
    - Rehaklinik Seewis
  - Sierre, Switzerland, 3960
    - Dr. med. Kiril Tzvetanov
  - Sursee, Switzerland, 6210
    - Herzpraxis Sursee
  - Thun, Switzerland, 3600
    - Spital STS AG
  - Thun, Switzerland, 3600
    - Kardiologie Aarezentrum Thun
  - Villars-sur-Glâne, Switzerland, 1752
    - Hopital Fribourgeois
  - Wallisellen, Switzerland, 8304
    - Herz- und Physiozentrum
  - Waltenschwil, Switzerland, 5622
    - Arztpraxis Waltenschwil
  - Will, Switzerland, 9500
    - Spital Will
  - Winterthur, Switzerland, 8400
    - Herz- und Kreislaufpraxis Winterthur
  - Winterthur, Switzerland, 8400
    - Medbase Winterthur Neuwiesen
  - Yverdon-les-Bains, Switzerland, 1400
    - Hôpital d'Yverdon-les-Bains
  - Zollikerberg, Switzerland, 8125
    - Spital Zollikerberg
  - Zurich, Switzerland, 8091
    - UniversitätsSpital Zürich
  - Zurich, Switzerland, 8001
    - SICADE Clinic
  - Zurich, Switzerland, 8002
    - Herzpraxis Enge ZH
  - Zurich, Switzerland, 8008
    - Gruppenpraxis Dr. Deseö / Dr. Deseö-Schütz / Dr. Lorger
  - Zurich, Switzerland, 8032
    - Herzklinik Hirslanden
  - Zurich, Switzerland, 8032
    - HerzKlinik Zürich Hirslanden
  - Zurich, Switzerland, 8055
    - Herzkreislaufpraxis

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Sampling Method

Non-Probability Sample

Study Population

Patients with chronic Heart Failure (HF) in a two cohort design: one cohort will receive first prescription of empagliflozin as routine therapy for HF, the other cohort will receive HF therapy with drugs with another mechanism of action.

Description

Inclusion Criteria:

Written informed consent prior to study participation
Male and female patients ≥ 18 years at Visit 1
Patients must be contractually capable and mentally able to understand and follow the instructions of the study personnel
Patients with diagnosis of chronic heart failure NYHA Class 2-4
Treatment-naïve for SGLT2i at visit 1
Women of childbearing potential must take appropriate precautions against getting pregnant according to approval of chosen HF drug(s)

Exclusion Criteria:

Missing physician's diagnosis of chronic heart failure
Patients hospitalized at visit 1
Life expectancy ≤ 12 months according to physician's assessment
Lack of informed consent
Pregnant or lactating females
Participation in a parallel interventional clinical trial
Chosen treatment with another SGLT2i drug than empagliflozin
Having been enrolled into the non-empagliflozin-arm of this non-interventional study
Current or prior treatment with SGLT2i at visit 1
Patients with contraindications according to current Summary of Product Characteristics (SmPC)
Patients with dependency or relationship to the treating physician

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Observational Models: Cohort
Time Perspectives: Prospective

Number of groups / cohorts

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Empagliflozin-treated patients Patients with heart failure (HF), with or without diabetes, who received their first prescription of empagliflozin were treated according to the approved product information, with a recommended daily dose of 10 milligrams (mg).	Drug: Empagliflozin Empagliflozin was administered according to the approved product information. Other Names: Jardiance®
Non-SGLT2i-treated patients Patients with heart failure (HF), with or without diabetes, who received drugs with mechanisms of action other than empagliflozin (drugs other than SGLT2i (Sodium-Glucose Co-Transporter 2 inhibitors)) were treated according to the approved product information.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change of the Kansas City Cardiomyopathy Questionnaire (KCCQ) Scores in Patients Newly Treated With Empagliflozin According to Routine Practice Time Frame: At baseline and at week 24.	Change from baseline to Week 24 of the Kansas City Cardiomyopathy Questionnaire (KCCQ) scores, calculated as [Week 24] - [Baseline]. The KCCQ includes 23 items across 7 domains: physical limitation, symptom stability, symptom frequency, symptom burden, self-efficacy, quality of life, and social limitation. This outcome measured the total symptom score (TTS), clinical summary score (CSS), and overall summary score (OSS) in the empagliflozin-treated patients as defined in the clinical study protocol. The TTS evaluates symptom frequency and burden and is calculated as the mean of the symptom frequency score and symptom burden score. The CSS is calculated as the mean of the physical limitation score and total symptom score. The OSS is calculated as the mean of the physical limitation score, total symptom score, quality of life score, and social limitation score. The TTS, CSS, and OSS are represented on a 0-to-100-point scale, where a higher score reflects better health status.	At baseline and at week 24.

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change of the New York Heart Association (NYHA) Class in Patients Newly Treated With Empagliflozin Time Frame: At baseline and at Week 24.	This outcome measured the number of patients newly treated with empagliflozin who experienced a change in the New York Heart Association (NYHA) Class from baseline to Week 24. The NYHA Classes of heart failure categorize patients with symptomatic or advanced heart failure based on their physical activity limitations. Class I patients present no limitation of physical activity, and ordinary physical activity does not cause fatigue, palpitations, or shortness of breath. Class II patients present a slight limitation of physical activity, characterized by fatigue, palpitations, shortness of breath, or chest pain as a result of ordinary physical activity. Class III patients are characterized by a marked limitation of physical activity, where less than ordinary activity causes fatigue, palpitations, shortness of breath, or chest pain. Class IV patients present symptoms of heart failure at rest, where any physical activity causes further discomfort.	At baseline and at Week 24.
Number of Participants With Comorbidities Time Frame: At baseline.	Number of patients with first prescription of empagliflozin and patients prescribed drugs other than SGLT2 inhibitors with concomitant disease/comorbidities. Concomitant diseases/comorbidities are presented according to the ICD-10-CM (the International Classification of Diseases, Tenth Revision, Clinical Modification) standardized system using the disease code.	At baseline.
Number of Participants With Concomitant Heart-failure (HF) Related Medication Time Frame: At baseline.	Number of patients who took concomitant HF-related medication.	At baseline.
Hospitalizations Due to Heart-failure in the Past 6 Months Before Baseline Time Frame: Up to 6 months prior to baseline visit.	Number of patients hospitalized at least one time due to heart failure (HF).	Up to 6 months prior to baseline visit.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Boehringer Ingelheim

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Related Info

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 18, 2022

Primary Completion (Actual)

July 25, 2024

Study Completion (Actual)

July 25, 2024

Study Registration Dates

First Submitted

April 22, 2022

First Submitted That Met QC Criteria

April 22, 2022

First Posted (Actual)

April 28, 2022

Study Record Updates

Last Update Posted (Estimated)

August 26, 2025

Last Update Submitted That Met QC Criteria

August 21, 2025

Last Verified

August 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

1245-0259

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Once the criteria in section "Time Frame" are fulfilled, researchers can use the following link https://www.mystudywindow.com/msw/datasharing to request access to the clinical study documents regarding this study, and upon a signed "Document Sharing Agreement".

Furthermore, researchers can request access to the clinical study data, for this and other listed studies, after the submission of a research proposal and according to the terms outlined in the website.

IPD Sharing Time Frame

After structured results have been posted, all regulatory activities are completed in the US and EU for the product and indication, and after the primary manuscript has been accepted for publication.

IPD Sharing Access Criteria

For study documents - upon signing of a 'Document Sharing Agreement'. For study data - 1. after the submission and approval of the research proposal (checks will be performed by the sponsor and/or the independent review panel, including checking that the planned analysis does not compete with sponsor's publication plan); 2. and upon signing of a legal agreement.

IPD Sharing Supporting Information Type

STUDY_PROTOCOL
SAP
CSR

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product

product manufactured in and exported from the U.S.

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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Study Overview

Status

Conditions

Intervention / Treatment

Study Type

Enrollment (Actual)

Contacts and Locations

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Sampling Method

Study Population

Description

Study Plan

How is the study designed?

Design Details

Number of groups / cohorts

Cohorts and Interventions

Group / Cohort

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Secondary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Collaborators and Investigators

Sponsor

Publications and helpful links

Helpful Links

Study record dates

Study Major Dates

Study Start (Actual)

Primary Completion (Actual)

Study Completion (Actual)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Actual)

Study Record Updates

Last Update Posted (Estimated)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

IPD Plan Description

IPD Sharing Time Frame

IPD Sharing Access Criteria

IPD Sharing Supporting Information Type

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product

product manufactured in and exported from the U.S.

Clinical Trials on Heart Failure

Clinical Trials on Empagliflozin

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