A Study of Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients.

June 9, 2026 updated by: Novartis Pharmaceuticals

A Randomized, Double-blind, Placebo-controlled Multicenter Study to Evaluate the Effect of Inclisiran on Preventing Major Adverse Cardiovascular Events in High-risk Primary Prevention Patients (VICTORION-1 PREVENT)

CKJX839D12302 is a pivotal Phase III study designed to test the hypothesis that treatment with inclisiran sodium 300 milligram (mg) subcutaneous (s.c.) administered on Day 1, Day 90, and every 6 months thereafter in patients at high cardiovascular (CV) risk without a prior major atherosclerotic cardiovascular disease (ASCVD) event will significantly reduce the risk of 4-Point-Major Adverse Cardiovascular Events (4P-MACE) defined as a composite of CV death, non-fatal myocardial infarction (MI), non-fatal ischemic stroke, and urgent coronary revascularization, compared to placebo.

Study Overview

Status

Active, not recruiting

Conditions

Primary Prevention of Atherosclerotic Cardiovascular Disease

Intervention / Treatment

Detailed Description

The purpose of this study is to evaluate inclisiran sodium 300 mg s.c. (equivalent to 284 mg inclisiran) compared to placebo on reducing the risk of 4P-MACE in adult patients at high risk for their first major adverse cardiovascular event.

Randomized participants will receive study medication (inclisiran or placebo), administered s.c. on Day 1, Day 90, then every 6 months thereafter. This is an event-driven study. Therefore, the study will continue until the required number of clinical events have occurred across both treatment arms, and all participants have a minimum of 3 years of follow-up during the double-blind treatment period.

Study Type

Interventional

Enrollment (Actual)

14012

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Argentina
- - Buenos Aires, Argentina, C1428DCO
    - Novartis Investigative Site
  - Buenos Aires, Argentina, W3400ABH
    - Novartis Investigative Site
  - Buenos Aires, Argentina, C1114AAP
    - Novartis Investigative Site
  - Caba, Argentina, C1015ABO
    - Novartis Investigative Site
  - Caba, Argentina, C1427CCL
    - Novartis Investigative Site
  - Capital Federal, Argentina, C1023AAB
    - Novartis Investigative Site
  - Corrientes, Argentina, 3400
    - Novartis Investigative Site
  - Córdoba, Argentina, X5000JHQ
    - Novartis Investigative Site
  - Córdoba, Argentina, X5000JHA
    - Novartis Investigative Site
  - Córdoba, Argentina, X5002HWE
    - Novartis Investigative Site
  - San Luis, Argentina, D5702JRS
    - Novartis Investigative Site
  - Santa Fe, Argentina, S3000EOZ
    - Novartis Investigative Site
- Buenos Aires
  - CABA, Buenos Aires, Argentina, C1221ADC
    - Novartis Investigative Site
  - CABA, Buenos Aires, Argentina, C1405BCH
    - Novartis Investigative Site
  - CABA, Buenos Aires, Argentina, 1425
    - Novartis Investigative Site
  - CABA, Buenos Aires, Argentina, C1406BOA
    - Novartis Investigative Site
  - CABA, Buenos Aires, Argentina, C1414AIF
    - Novartis Investigative Site
  - CABA, Buenos Aires, Argentina, C1425AGC
    - Novartis Investigative Site
  - CABA, Buenos Aires, Argentina, C1426ABP
    - Novartis Investigative Site
  - CABA, Buenos Aires, Argentina, C1280AEB
    - Novartis Investigative Site
  - CABA, Buenos Aires, Argentina, C1407FWE
    - Novartis Investigative Site
  - Caba, Buenos Aires, Argentina, C1119ACN
    - Novartis Investigative Site
  - Lanus, Buenos Aires, Argentina, B8000XAV
    - Novartis Investigative Site
  - Mar del Plata, Buenos Aires, Argentina, B7600ENA
    - Novartis Investigative Site
  - Ramos Mejía, Buenos Aires, Argentina, B1704ETD
    - Novartis Investigative Site
  - San Martín, Buenos Aires, Argentina, B1650CSQ
    - Novartis Investigative Site
- Cordobaa
  - Córdoba, Cordobaa, Argentina, X5003DCE
    - Novartis Investigative Site
- Córdoba Province
  - Córdoba, Córdoba Province, Argentina, 5200
    - Novartis Investigative Site
  - Córdoba, Córdoba Province, Argentina, X5000
    - Novartis Investigative Site
  - Córdoba, Córdoba Province, Argentina, X5003DCP
    - Novartis Investigative Site
  - Córdoba, Córdoba Province, Argentina, X5016KEH
    - Novartis Investigative Site
- Entre Ríos Province
  - Concepcion Uruguay, Entre Ríos Province, Argentina, 3260
    - Novartis Investigative Site
  - Paraná, Entre Ríos Province, Argentina, 3100
    - Novartis Investigative Site
- Formosa Province
  - Formosa, Formosa Province, Argentina, P3600MPD
    - Novartis Investigative Site
- Mendoza Province
  - Mendoza, Mendoza Province, Argentina, 5500
    - Novartis Investigative Site
- Salta Province
  - Salta, Salta Province, Argentina, A4406BPF
    - Novartis Investigative Site
- San Miguel de Tucuman
  - San Miguel de Tucumán, San Miguel de Tucuman, Argentina, T4000ICL
    - Novartis Investigative Site
- Santa Fe Province
  - Grandero Baigorria, Santa Fe Province, Argentina, S2152
    - Novartis Investigative Site
  - Rosario, Santa Fe Province, Argentina, S2000DSV
    - Novartis Investigative Site
  - Rosario, Santa Fe Province, Argentina, S2000DBS
    - Novartis Investigative Site
  - Rosario, Santa Fe Province, Argentina, S2000CVD
    - Novartis Investigative Site
  - Santa Fe, Santa Fe Province, Argentina, S3000FWO
    - Novartis Investigative Site
- Tucumán Province
  - San Miguel, Tucumán Province, Argentina, 4400
    - Novartis Investigative Site
  - San Miguel Tucuman, Tucumán Province, Argentina, T4000IFL
    - Novartis Investigative Site
Australia
- Australian Capital Territory
  - Garran, Australian Capital Territory, Australia, 2605
    - Novartis Investigative Site
- New South Wales
  - Camperdown, New South Wales, Australia, 2050
    - Novartis Investigative Site
  - Concord, New South Wales, Australia, 2139
    - Novartis Investigative Site
- Queensland
  - Auchenflower, Queensland, Australia, 4066
    - Novartis Investigative Site
  - Sippy Downs, Queensland, Australia, 4556
    - Novartis Investigative Site
  - Woolloongabba, Queensland, Australia, 4102
    - Novartis Investigative Site
- South Australia
  - Adelaide, South Australia, Australia, 5000
    - Novartis Investigative Site
  - Leabrook, South Australia, Australia, 5068
    - Novartis Investigative Site
- Tasmania
  - Hobart, Tasmania, Australia, 7000
    - Novartis Investigative Site
- Victoria
  - Clayton, Victoria, Australia, 3168
    - Novartis Investigative Site
  - Heidelberg, Victoria, Australia, 3084
    - Novartis Investigative Site
  - Malvern East, Victoria, Australia, 3145
    - Novartis Investigative Site
- Western Australia
  - Joondalup, Western Australia, Australia, 6027
    - Novartis Investigative Site
Austria
- - Braunau am Inn, Austria, 5280
    - Novartis Investigative Site
  - Graz, Austria, 8036
    - Novartis Investigative Site
  - Linz, Austria, 4021
    - Novartis Investigative Site
  - Vienna, Austria, 1190
    - Novartis Investigative Site
Belgium
- - Dendermonde, Belgium, 9200
    - Novartis Investigative Site
  - Mechelen, Belgium, 2800
    - Novartis Investigative Site
- Limburg
  - Genk, Limburg, Belgium, 3600
    - Novartis Investigative Site
  - Hasselt, Limburg, Belgium, 3500
    - Novartis Investigative Site
- Oost Vlaanderen
  - Aalst, Oost Vlaanderen, Belgium, 9300
    - Novartis Investigative Site
Brazil
- - Campinas, Brazil, 13092-133
    - Novartis Investigative Site
  - Rio de Janeiro, Brazil, 20241-180
    - Novartis Investigative Site
- Alagoas
  - Maceió, Alagoas, Brazil, 57051-160
    - Novartis Investigative Site
- Espírito Santo
  - Vitória, Espírito Santo, Brazil, 29055-450
    - Novartis Investigative Site
- Estado de Bahia
  - Salvador, Estado de Bahia, Brazil, 40170-130
    - Novartis Investigative Site
  - Salvador, Estado de Bahia, Brazil, 41810-011
    - Novartis Investigative Site
- Federal District
  - Brasília, Federal District, Brazil, 71625-009
    - Novartis Investigative Site
  - Brasília, Federal District, Brazil, 70390-700
    - Novartis Investigative Site
  - Brasília, Federal District, Brazil, 70673-416
    - Novartis Investigative Site
- Minas Gerais
  - Belo Horizonte, Minas Gerais, Brazil, 30140 062
    - Novartis Investigative Site
  - Belo Horizonte, Minas Gerais, Brazil, 30150-320
    - Novartis Investigative Site
  - Uberlândia, Minas Gerais, Brazil, 38400 500
    - Novartis Investigative Site
- Paraná
  - Curitiba, Paraná, Brazil, 80730-150
    - Novartis Investigative Site
  - Curitiba, Paraná, Brazil, 80045-170
    - Novartis Investigative Site
- Rio Grande do Sul
  - Canoas, Rio Grande do Sul, Brazil, 92425 900
    - Novartis Investigative Site
  - Pelotas, Rio Grande do Sul, Brazil, 96015-290
    - Novartis Investigative Site
  - Porto Alegre, Rio Grande do Sul, Brazil, 90880-480
    - Novartis Investigative Site
  - Porto Alegre, Rio Grande do Sul, Brazil, 90560-032
    - Novartis Investigative Site
  - Porto Alegre, Rio Grande do Sul, Brazil, 90160-093
    - Novartis Investigative Site
- Rio de Janeiro
  - Rio de Janeiro, Rio de Janeiro, Brazil, 22061-080
    - Novartis Investigative Site
- Santa Catarina
  - Blumenau, Santa Catarina, Brazil, 89020-430
    - Novartis Investigative Site
- Sergipe
  - Aracaju, Sergipe, Brazil, 49055-530
    - Novartis Investigative Site
- São Paulo
  - Campinas, São Paulo, Brazil, 13060 080
    - Novartis Investigative Site
  - Ribeirão Preto, São Paulo, Brazil, 14048-900
    - Novartis Investigative Site
  - Santo André, São Paulo, Brazil, 09030-010
    - Novartis Investigative Site
  - Sao Jose Rio Preto, São Paulo, Brazil, 15090 000
    - Novartis Investigative Site
  - São José dos Campos, São Paulo, Brazil, 12243-280
    - Novartis Investigative Site
  - São Paulo, São Paulo, Brazil, 04266 010
    - Novartis Investigative Site
  - São Paulo, São Paulo, Brazil, 01323 000
    - Novartis Investigative Site
  - São Paulo, São Paulo, Brazil, 01323001
    - Novartis Investigative Site
  - São Paulo, São Paulo, Brazil, 04012-909
    - Novartis Investigative Site
  - Votuporanga, São Paulo, Brazil, 15500-269
    - Novartis Investigative Site
Bulgaria
- - Blagoevgrad, Bulgaria, 270 0
    - Novartis Investigative Site
  - Burgas, Bulgaria, 8001
    - Novartis Investigative Site
  - Gabrovo, Bulgaria, 5300
    - Novartis Investigative Site
  - Kyustendil, Bulgaria, 2500
    - Novartis Investigative Site
  - Pleven, Bulgaria, 5800
    - Novartis Investigative Site
  - Plovdiv, Bulgaria, 4002
    - Novartis Investigative Site
  - Sandanski, Bulgaria, 2800
    - Novartis Investigative Site
  - Sofia, Bulgaria, 1233
    - Novartis Investigative Site
  - Sofia, Bulgaria, 1606
    - Novartis Investigative Site
  - Sofia, Bulgaria, 1750
    - Novartis Investigative Site
  - Sofia, Bulgaria, 1510
    - Novartis Investigative Site
  - Sofia, Bulgaria, 1504
    - Novartis Investigative Site
  - Stara Zagora, Bulgaria, 6000
    - Novartis Investigative Site
  - Varna, Bulgaria, 9010
    - Novartis Investigative Site
  - Veliko Tarnovo, Bulgaria, 5000
    - Novartis Investigative Site
- Bulgaria
  - Sofia, Bulgaria, Bulgaria, 1202
    - Novartis Investigative Site
- Burgas
  - Burgas, Burgas, Bulgaria, 8000
    - Novartis Investigative Site
Canada
- Alberta
  - Calgary, Alberta, Canada, T2H 2G4
    - Novartis Investigative Site
  - Edmonton, Alberta, Canada, T6K 4C1
    - Novartis Investigative Site
  - Red Deer, Alberta, Canada, T4P 1K4
    - Novartis Investigative Site
- British Columbia
  - Kelowna, British Columbia, Canada, V1Y 3J8
    - Novartis Investigative Site
  - Vancouver, British Columbia, Canada, V6Z 1Y6
    - Novartis Investigative Site
- New Brunswick
  - Moncton, New Brunswick, Canada, E1G 1A7
    - Novartis Investigative Site
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 2Y9
    - Novartis Investigative Site
  - New Minas, Nova Scotia, Canada, B4N 3R7
    - Novartis Investigative Site
- Ontario
  - Barrie, Ontario, Canada, L4N 7L3
    - Novartis Investigative Site
  - Brampton, Ontario, Canada, L6S 0C6
    - Novartis Investigative Site
  - Etobicoke, Ontario, Canada, M9R 4E1
    - Novartis Investigative Site
  - Guelph, Ontario, Canada, N1H 1B1
    - Novartis Investigative Site
  - Hamilton, Ontario, Canada, L8L 5G4
    - Novartis Investigative Site
  - London, Ontario, Canada, N6A 5W9
    - Novartis Investigative Site
  - Napean, Ontario, Canada, K2J 0V2
    - Novartis Investigative Site
  - Newmarket, Ontario, Canada, L3Y 2P6
    - Novartis Investigative Site
  - North York, Ontario, Canada, M6B 3H7
    - Novartis Investigative Site
  - Oshawa, Ontario, Canada, L1J 2K9
    - Novartis Investigative Site
  - Scarborough Village, Ontario, Canada, M1B 5N1
    - Novartis Investigative Site
  - Thornhill, Ontario, Canada, L4J 8L7
    - Novartis Investigative Site
  - Toronto, Ontario, Canada, M4G 3E8
    - Novartis Investigative Site
- Quebec
  - Lévis, Quebec, Canada, G6W 5M6
    - Novartis Investigative Site
  - Mirabel, Quebec, Canada, J7J 2K8
    - Novartis Investigative Site
  - Montreal, Quebec, Canada, H4A 3J1
    - Novartis Investigative Site
  - Québec, Quebec, Canada, G2J 0C4
    - Novartis Investigative Site
  - Québec, Quebec, Canada, G1V 4G5
    - Novartis Investigative Site
  - Terrebonne, Quebec, Canada, J6X 4P7
    - Novartis Investigative Site
  - Trois-Rivières, Quebec, Canada, G9A 4P3
    - Novartis Investigative Site
  - Victoriaville, Quebec, Canada, G6P 3Z8
    - Novartis Investigative Site
China
- - Beijing, China, 100730
    - Novartis Investigative Site
  - Beijing, China, 100083
    - Novartis Investigative Site
  - Jining, China, 272011
    - Novartis Investigative Site
  - Shanghai, China, 200120
    - Novartis Investigative Site
  - Tianjin, China, 300140
    - Novartis Investigative Site
- Guangdong
  - Guangzhou, Guangdong, China, 510080
    - Novartis Investigative Site
  - Guangzhou, Guangdong, China, 510000
    - Novartis Investigative Site
- Guangxi
  - Nanning, Guangxi, China, 530022
    - Novartis Investigative Site
- Hebei
  - Cangzhou, Hebei, China, 061002
    - Novartis Investigative Site
  - Shijiazhuang, Hebei, China, 050000
    - Novartis Investigative Site
  - Tangshan, Hebei, China, 063000
    - Novartis Investigative Site
  - Xingtai, Hebei, China, 054000
    - Novartis Investigative Site
- Heilongjiang
  - Daqing, Heilongjiang, China, 163001
    - Novartis Investigative Site
  - Harbin, Heilongjiang, China, 150000
    - Novartis Investigative Site
  - Harbin, Heilongjiang, China, 150001
    - Novartis Investigative Site
- Henan
  - Luoyang, Henan, China, 471002
    - Novartis Investigative Site
  - Pingdingshan, Henan, China, 467000
    - Novartis Investigative Site
  - Zhengzhou, Henan, China, 450003
    - Novartis Investigative Site
- Hubei
  - Huangshi, Hubei, China, 435000
    - Novartis Investigative Site
  - Wuhan, Hubei, China, 430081
    - Novartis Investigative Site
- Hunan
  - Changsha, Hunan, China, 410011
    - Novartis Investigative Site
  - Changsha, Hunan, China, 410005
    - Novartis Investigative Site
- Inner Mongolia
  - Hohhot, Inner Mongolia, China, 010017
    - Novartis Investigative Site
- Jiangsu
  - Changzhou, Jiangsu, China, 213004
    - Novartis Investigative Site
  - Xuzhou, Jiangsu, China, 221003
    - Novartis Investigative Site
- Jiangxi
  - Nanchang, Jiangxi, China, 330009
    - Novartis Investigative Site
- Jilin
  - Tonghua, Jilin, China, 134000
    - Novartis Investigative Site
- Liaoning
  - Dalian, Liaoning, China, 116000
    - Novartis Investigative Site
  - Jinzhou, Liaoning, China, 121001
    - Novartis Investigative Site
  - Shenyang, Liaoning, China, 110016
    - Novartis Investigative Site
- Ningxia
  - Yinchuan, Ningxia, China, 750004
    - Novartis Investigative Site
- Shaanxi
  - Xianyang, Shaanxi, China, 712000
    - Novartis Investigative Site
- Shandong
  - Jinan, Shandong, China, 250021
    - Novartis Investigative Site
  - Jining, Shandong, China, 272000
    - Novartis Investigative Site
  - Qingdao, Shandong, China, 266011
    - Novartis Investigative Site
  - Zibo, Shandong, China, 255000
    - Novartis Investigative Site
- Shanxi
  - Xian, Shanxi, China, 710061
    - Novartis Investigative Site
- Tianjin Municipality
  - Tianjin, Tianjin Municipality, China, 300121
    - Novartis Investigative Site
- Zhejiang
  - Hangzhou, Zhejiang, China, 310006
    - Novartis Investigative Site
  - Hangzhou, Zhejiang, China, 310000
    - Novartis Investigative Site
  - Lishui, Zhejiang, China, 323000
    - Novartis Investigative Site
  - Wenzhou, Zhejiang, China, 325000
    - Novartis Investigative Site
Colombia
- - Bogotá, Colombia, 110221
    - Novartis Investigative Site
  - Cali, Colombia, 760004
    - Novartis Investigative Site
  - Manizales, Colombia, 170008
    - Novartis Investigative Site
  - Medellín, Colombia, 050012
    - Novartis Investigative Site
  - Medellín, Colombia, 050037
    - Novartis Investigative Site
  - Medellín, Colombia, 050034
    - Novartis Investigative Site
  - San Gil, Colombia, 684031
    - Novartis Investigative Site
- Antioquia
  - Medellín, Antioquia, Colombia, 050021
    - Novartis Investigative Site
  - Medellín, Antioquia, Colombia, 050010
    - Novartis Investigative Site
- Atlántico
  - Barranquilla, Atlántico, Colombia, 080002
    - Novartis Investigative Site
  - Barranquilla, Atlántico, Colombia, 080012
    - Novartis Investigative Site
  - Barranquilla, Atlántico, Colombia, 080020
    - Novartis Investigative Site
- Colombia
  - Barranquilla, Colombia, Colombia, 080020
    - Novartis Investigative Site
- Cundinamarca
  - Chía, Cundinamarca, Colombia, 250001
    - Novartis Investigative Site
- Santander Department
  - Bucaramanga, Santander Department, Colombia, 681017
    - Novartis Investigative Site
  - Floridablanca, Santander Department, Colombia, 57-7
    - Novartis Investigative Site
- Tolima Department
  - Ibague, Tolima Department, Colombia, 730006
    - Novartis Investigative Site
- Valle del Cauca Department
  - Cali, Valle del Cauca Department, Colombia, 760001
    - Novartis Investigative Site
Croatia
- - Krapinske Toplice, Croatia, 49217
    - Novartis Investigative Site
  - Opatija, Croatia, 51410
    - Novartis Investigative Site
  - Osijek, Croatia, 31000
    - Novartis Investigative Site
  - Pula, Croatia, 52100
    - Novartis Investigative Site
  - Varaždin, Croatia, 42000
    - Novartis Investigative Site
  - Vinkovci, Croatia, 32100
    - Novartis Investigative Site
  - Zagreb, Croatia, 10000
    - Novartis Investigative Site
- City of Zagreb
  - Zagreb, City of Zagreb, Croatia, 10000
    - Novartis Investigative Site
- County of Osijek-Baranja
  - Osijek, County of Osijek-Baranja, Croatia, 31000
    - Novartis Investigative Site
- Croatia
  - Krapinske Toplice, Croatia, Croatia, 49 217
    - Novartis Investigative Site
  - Slavonski Brod, Croatia, Croatia, 35000
    - Novartis Investigative Site
  - Zagreb, Croatia, Croatia, 10000
    - Novartis Investigative Site
- Primorje-Gorski Kotar County
  - Rijeka, Primorje-Gorski Kotar County, Croatia, 51000
    - Novartis Investigative Site
Czechia
- - Brandýs nad Labem, Czechia, 250 01
    - Novartis Investigative Site
  - Brno, Czechia, 602 00
    - Novartis Investigative Site
  - Hlučín, Czechia, 748 01
    - Novartis Investigative Site
  - Hodonín, Czechia, 695 01
    - Novartis Investigative Site
  - Jihlava, Czechia, 586 01
    - Novartis Investigative Site
  - Kolín, Czechia, 280 20
    - Novartis Investigative Site
  - Liberec, Czechia, 46063
    - Novartis Investigative Site
  - Mariánské Lázně, Czechia, 353 01
    - Novartis Investigative Site
  - Náchod, Czechia, 547 01
    - Novartis Investigative Site
  - Olomouc, Czechia, 772 00
    - Novartis Investigative Site
  - Ostrava, Czechia, 710 00
    - Novartis Investigative Site
  - Pardubice, Czechia, 532 03
    - Novartis Investigative Site
  - Plzen Bory, Czechia, 301 00
    - Novartis Investigative Site
  - Prague, Czechia, 128 08
    - Novartis Investigative Site
  - Prague, Czechia, 100 34
    - Novartis Investigative Site
  - Prague, Czechia, 158 00
    - Novartis Investigative Site
  - Prague, Czechia, 148 00
    - Novartis Investigative Site
  - Prague, Czechia, 104 00
    - Novartis Investigative Site
  - Trutnov, Czechia, 460 63
    - Novartis Investigative Site
  - Uherské Hradiště, Czechia, 686 01
    - Novartis Investigative Site
  - Zlín, Czechia, 760 01
    - Novartis Investigative Site
  - Znojmo, Czechia, 669 02
    - Novartis Investigative Site
  - Ústí nad Labem, Czechia, 400 01
    - Novartis Investigative Site
  - Český Krumlov, Czechia, 381 01
    - Novartis Investigative Site
- CZE
  - Ostrava, CZE, Czechia, 728 80
    - Novartis Investigative Site
- Chlumec Nad Cidlinou
  - Chlumec nad Cidlinou, Chlumec Nad Cidlinou, Czechia, 503 51
    - Novartis Investigative Site
- Czech Republic
  - Louny, Czech Republic, Czechia, 440 01
    - Novartis Investigative Site
  - Ostrava, Czech Republic, Czechia, 725 27
    - Novartis Investigative Site
  - Ústí nad Labem, Czech Republic, Czechia, 400 01
    - Novartis Investigative Site
- Olomouc Region
  - Přerov, Olomouc Region, Czechia, 750 02
    - Novartis Investigative Site
- Zabreh
  - Ostrava, Zabreh, Czechia, 700 30
    - Novartis Investigative Site
Denmark
- - Aarhus N, Denmark, 8200
    - Novartis Investigative Site
  - Copenhagen S, Denmark, 2300
    - Novartis Investigative Site
  - Esbjerg, Denmark, 6700
    - Novartis Investigative Site
  - Gandrup, Denmark, 9362
    - Novartis Investigative Site
  - Herlev, Denmark, 2730
    - Novartis Investigative Site
  - Herlev, Denmark, DK-2730
    - Novartis Investigative Site
  - Herning, Denmark, 7400
    - Novartis Investigative Site
  - Kobenhavn N V, Denmark, 2400
    - Novartis Investigative Site
  - Roskilde, Denmark, 4000
    - Novartis Investigative Site
  - Svendborg, Denmark, 5700
    - Novartis Investigative Site
  - Vejle, Denmark, 7100
    - Novartis Investigative Site
Estonia
- - Pärnu, Estonia, 80018
    - Novartis Investigative Site
  - Tallinn, Estonia, 13419
    - Novartis Investigative Site
  - Tallinn, Estonia, 10138
    - Novartis Investigative Site
  - Tallinn, Estonia, 13619
    - Novartis Investigative Site
  - Tallinn, Estonia, 10128
    - Novartis Investigative Site
  - Tartu, Estonia, 50708
    - Novartis Investigative Site
- Estonia
  - Tartu, Estonia, Estonia, 50406
    - Novartis Investigative Site
France
- - Avignon, France, 84000
    - Novartis Investigative Site
  - Besançon, France, 25030
    - Novartis Investigative Site
  - Bobigny, France, 93009
    - Novartis Investigative Site
  - Bordeaux, France, 33075
    - Novartis Investigative Site
  - Béziers, France, 34525
    - Novartis Investigative Site
  - Caen, France, 14033
    - Novartis Investigative Site
  - Compiègne, France, 60321
    - Novartis Investigative Site
  - Dijon, France, 21000
    - Novartis Investigative Site
  - Marseille, France, 13005
    - Novartis Investigative Site
  - Montauban, France, 82017
    - Novartis Investigative Site
  - Montpellier, France, 34295
    - Novartis Investigative Site
  - Nantes, France, 44093
    - Novartis Investigative Site
  - Nice, France, 06202
    - Novartis Investigative Site
  - Orléans, France, 45100
    - Novartis Investigative Site
  - Paris, France, 75013
    - Novartis Investigative Site
  - Paris, France, 75015
    - Novartis Investigative Site
  - Paris, France, 75012
    - Novartis Investigative Site
  - Paris, France, 75018
    - Novartis Investigative Site
  - Poitiers, France, 86021
    - Novartis Investigative Site
  - Rouen, France, 76031
    - Novartis Investigative Site
  - Strasbourg, France, 67091
    - Novartis Investigative Site
  - Tourcoing, France, 59208
    - Novartis Investigative Site
  - Valenciennes, France, 59300
    - Novartis Investigative Site
  - Vandœuvre-lès-Nancy, France, 54511
    - Novartis Investigative Site
  - Villeneuve-d'Ascq, France, 59650
    - Novartis Investigative Site
Greece
- - Athens, Greece, 115 27
    - Novartis Investigative Site
  - Athens, Greece, 151 23
    - Novartis Investigative Site
  - Athens, Greece, 115 21
    - Novartis Investigative Site
  - Heraklion Crete., Greece, 715 00
    - Novartis Investigative Site
  - Ioannina, Greece, 455 00
    - Novartis Investigative Site
  - Thessaloniki, Greece, 570 01
    - Novartis Investigative Site
  - Thessaloniki, Greece, 546 42
    - Novartis Investigative Site
  - Thessaloniki, Greece, 564 03
    - Novartis Investigative Site
Hong Kong
- - Hong Kong SAR, Hong Kong, 999077
    - Novartis Investigative Site
  - Kowloon, Hong Kong, 999077
    - Novartis Investigative Site
  - Shatin, Hong Kong, 999077
    - Novartis Investigative Site
- Hong Kong
  - Hong Kong, Hong Kong, Hong Kong, 999077
    - Novartis Investigative Site
Hungary
- - Balatonfüred, Hungary, 8230
    - Novartis Investigative Site
  - Budapest, Hungary, H-1083
    - Novartis Investigative Site
  - Budapest, Hungary, H-1097
    - Novartis Investigative Site
  - Budapest, Hungary, 1146
    - Novartis Investigative Site
  - Budapest, Hungary, 1036
    - Novartis Investigative Site
  - Budapest, Hungary, H-1145
    - Novartis Investigative Site
  - Budapest, Hungary, 1132
    - Novartis Investigative Site
  - Debrecen, Hungary, 4027
    - Novartis Investigative Site
  - Hatvan, Hungary, 3000
    - Novartis Investigative Site
  - Hosszúhetény, Hungary, 7694
    - Novartis Investigative Site
  - Mosanmagyarovar, Hungary, 9200
    - Novartis Investigative Site
  - Nyíregyháza, Hungary, 4400
    - Novartis Investigative Site
  - Pécs, Hungary, 7623
    - Novartis Investigative Site
  - Szeged, Hungary, 6725
    - Novartis Investigative Site
  - Szekszárd, Hungary, 7100
    - Novartis Investigative Site
- Pest County
  - Budapest, Pest County, Hungary, 1132
    - Novartis Investigative Site
- Zala County
  - Zalaegerszeg, Zala County, Hungary, 8900
    - Novartis Investigative Site
India
- - Coimbatore, India, 641018
    - Novartis Investigative Site
  - New Delhi, India, 110029
    - Novartis Investigative Site
  - Uttarakhand, India, 263153
    - Novartis Investigative Site
- Andhra Pradesh
  - Guntur, Andhra Pradesh, India, 522001
    - Novartis Investigative Site
- Gujarat
  - Ahmedabad, Gujarat, India, 380054
    - Novartis Investigative Site
  - Ahmedabad, Gujarat, India, 380060
    - Novartis Investigative Site
- Karnataka
  - Bangalore, Karnataka, India, 560069
    - Novartis Investigative Site
  - Belagavi, Karnataka, India, 590010
    - Novartis Investigative Site
  - Mangalore, Karnataka, India, 575018
    - Novartis Investigative Site
  - Manipal, Karnataka, India, 576104
    - Novartis Investigative Site
  - Mysore, Karnataka, India, 570004
    - Novartis Investigative Site
  - Mysore, Karnataka, India, 570015
    - Novartis Investigative Site
- Kerala
  - Kochi, Kerala, India, 682041
    - Novartis Investigative Site
  - Kochi, Kerala, India, 682018
    - Novartis Investigative Site
- Maharashtra
  - Nagpur, Maharashtra, India, 440012
    - Novartis Investigative Site
  - Nagpur, Maharashtra, India, 441108
    - Novartis Investigative Site
  - Nashik, Maharashtra, India, 422005
    - Novartis Investigative Site
  - Pune, Maharashtra, India, 411004
    - Novartis Investigative Site
  - Pune, Maharashtra, India, 411045
    - Novartis Investigative Site
- National Capital Territory of Delhi
  - New Delhi, National Capital Territory of Delhi, India, 110060
    - Novartis Investigative Site
  - New Delhi, National Capital Territory of Delhi, India, 110002
    - Novartis Investigative Site
- Rajasthan
  - Ajmer, Rajasthan, India, 305001
    - Novartis Investigative Site
  - Bikaner, Rajasthan, India, 334003
    - Novartis Investigative Site
  - Jaipur, Rajasthan, India, 302001
    - Novartis Investigative Site
  - Jaipur, Rajasthan, India, 302020
    - Novartis Investigative Site
- Tamil Nadu
  - Chennai, Tamil Nadu, India, 600006
    - Novartis Investigative Site
  - Chennai, Tamil Nadu, India, 600116
    - Novartis Investigative Site
  - Coimbatore, Tamil Nadu, India, 641037
    - Novartis Investigative Site
  - Coimbatore, Tamil Nadu, India, 641009
    - Novartis Investigative Site
  - Madurai, Tamil Nadu, India, 625020
    - Novartis Investigative Site
- Uttar Pradesh
  - Kanpur, Uttar Pradesh, India, 208002
    - Novartis Investigative Site
  - Lucknow, Uttar Pradesh, India, 226003
    - Novartis Investigative Site
- Uttarakhand
  - Dehradun, Uttarakhand, India, 248001
    - Novartis Investigative Site
- Uttrakhand
  - Dehradun, Uttrakhand, India, 248104
    - Novartis Investigative Site
- West Bengal
  - Kolkata, West Bengal, India, 700 020
    - Novartis Investigative Site
Israel
- - Beersheba, Israel, 8457108
    - Novartis Investigative Site
  - Haifa, Israel, 3104802
    - Novartis Investigative Site
  - Jerusalem, Israel, 9112001
    - Novartis Investigative Site
  - Nahariya, Israel, 2210001
    - Novartis Investigative Site
  - Poria – Neve Oved, Israel, 1528001
    - Novartis Investigative Site
  - Ramat Gan, Israel, 5265601
    - Novartis Investigative Site
  - Rehovot, Israel, 7661041
    - Novartis Investigative Site
  - Sefad, Israel, 1311300
    - Novartis Investigative Site
  - Tel Aviv, Israel, 6423906
    - Novartis Investigative Site
- Gush Dan
  - Holon, Gush Dan, Israel, 5845997
    - Novartis Investigative Site
Italy
- - Naples, Italy, 80131
    - Novartis Investigative Site
  - Naples, Italy, 80138
    - Novartis Investigative Site
- AN
  - Ancona, AN, Italy, 60128
    - Novartis Investigative Site
- BS
  - Brescia, BS, Italy, 25123
    - Novartis Investigative Site
- CE
  - Caserta, CE, Italy, 81100
    - Novartis Investigative Site
- CH
  - Chieti, CH, Italy, 66100
    - Novartis Investigative Site
- CZ
  - Catanzaro, CZ, Italy, 88100
    - Novartis Investigative Site
- FI
  - Florence, FI, Italy, 50134
    - Novartis Investigative Site
- GE
  - Chiavari, GE, Italy, 16043
    - Novartis Investigative Site
  - Genova, GE, Italy, 16132
    - Novartis Investigative Site
- IS
  - Pozzilli, IS, Italy, 86077
    - Novartis Investigative Site
- LT
  - Latina, LT, Italy, 04100
    - Novartis Investigative Site
- MB
  - Monza, MB, Italy, 20900
    - Novartis Investigative Site
- ME
  - Messina, ME, Italy, 98125
    - Novartis Investigative Site
- MI
  - Cinisello Balsamo, MI, Italy, 20092
    - Novartis Investigative Site
  - Milan, MI, Italy, 20162
    - Novartis Investigative Site
  - Milan, MI, Italy, 20132
    - Novartis Investigative Site
  - Milan, MI, Italy, 20122
    - Novartis Investigative Site
  - Milan, MI, Italy, 20138
    - Novartis Investigative Site
  - Milan, MI, Italy, 20100
    - Novartis Investigative Site
  - Milan, MI, Italy, 20157
    - Novartis Investigative Site
- MO
  - Modena, MO, Italy, 41126
    - Novartis Investigative Site
- PG
  - Perugia, PG, Italy, 06129
    - Novartis Investigative Site
- PI
  - Pisa, PI, Italy, 56124
    - Novartis Investigative Site
  - Pisa, PI, Italy, 56126
    - Novartis Investigative Site
- RM
  - Roma, RM, Italy, 00168
    - Novartis Investigative Site
  - Roma, RM, Italy, 00161
    - Novartis Investigative Site
- SI
  - Siena, SI, Italy, 53100
    - Novartis Investigative Site
Latvia
- - Daugavpils, Latvia, LV-5417
    - Novartis Investigative Site
  - Kuldīga, Latvia, LV-3300
    - Novartis Investigative Site
  - Liepāja, Latvia, LV 3401
    - Novartis Investigative Site
  - Ogre, Latvia, LV-5001
    - Novartis Investigative Site
  - Riga, Latvia, LV 1002
    - Novartis Investigative Site
  - Riga, Latvia, LV-1038
    - Novartis Investigative Site
  - Riga, Latvia, LV-1001
    - Novartis Investigative Site
Lithuania
- - Alytus, Lithuania, LT-62386
    - Novartis Investigative Site
  - Kaunas, Lithuania, LT-50009
    - Novartis Investigative Site
  - Kaunas, Lithuania, 49449
    - Novartis Investigative Site
  - Panevezys, Lithuania, 35144
    - Novartis Investigative Site
  - Vilnius, Lithuania, LT-08406
    - Novartis Investigative Site
  - Šiauliai, Lithuania, 76206
    - Novartis Investigative Site
- Kaunas County
  - Kaunas, Kaunas County, Lithuania, LT-50177
    - Novartis Investigative Site
  - Kaunas, Kaunas County, Lithuania, 50161
    - Novartis Investigative Site
- Klaipėda County
  - Klaipėda, Klaipėda County, Lithuania, 92288
    - Novartis Investigative Site
  - Klaipėda, Klaipėda County, Lithuania, 91131
    - Novartis Investigative Site
Malaysia
- - Johor Bahru, Malaysia, 80100
    - Novartis Investigative Site
  - Kuala Lumpur, Malaysia, 50400
    - Novartis Investigative Site
- Kedah
  - Alor Star, Kedah, Malaysia, 05460
    - Novartis Investigative Site
- Kelantan
  - Kota Bharu, Kelantan, Malaysia, 16150
    - Novartis Investigative Site
- Kuala Lumpur
  - Kuala Lumpur, Kuala Lumpur, Malaysia, 50586
    - Novartis Investigative Site
- Negeri Sembilan
  - Seremban, Negeri Sembilan, Malaysia, 70300
    - Novartis Investigative Site
- Perak
  - Ipoh, Perak, Malaysia, 30450
    - Novartis Investigative Site
  - Seri Manjung, Perak, Malaysia, 32040
    - Novartis Investigative Site
  - Taiping, Perak, Malaysia, 34000
    - Novartis Investigative Site
- Pulau Pinang
  - Timur Laut, Pulau Pinang, Malaysia, 11500
    - Novartis Investigative Site
- Sarawak
  - Kuching, Sarawak, Malaysia, 93586
    - Novartis Investigative Site
  - Miri, Sarawak, Malaysia, 98000
    - Novartis Investigative Site
- Selangor
  - Sungai Buloh, Selangor, Malaysia, 47000
    - Novartis Investigative Site
Mexico
- - Aguascalientes, Mexico, 20230
    - Novartis Investigative Site
  - Aguascalientes, Mexico, 20116
    - Novartis Investigative Site
  - Chihuahua City, Mexico, 31238
    - Novartis Investigative Site
  - Distrito Federal, Mexico, 14080
    - Novartis Investigative Site
  - Distrito Federal, Mexico, 03100
    - Novartis Investigative Site
  - Mexico City, Mexico, 06760
    - Novartis Investigative Site
  - Mexico D F, Mexico, 06720
    - Novartis Investigative Site
  - Oaxaca City, Mexico, 68020
    - Novartis Investigative Site
  - Veracruz, Mexico, 91900
    - Novartis Investigative Site
- Guanajuato
  - León, Guanajuato, Mexico, 37160
    - Novartis Investigative Site
- Hidalgo
  - Actopan, Hidalgo, Mexico, 42500
    - Novartis Investigative Site
- Jalisco
  - Guadalajara, Jalisco, Mexico, 44670
    - Novartis Investigative Site
  - Guadalajara, Jalisco, Mexico, 44260
    - Novartis Investigative Site
  - Guadalajara, Jalisco, Mexico, 44340
    - Novartis Investigative Site
- Mexico City
  - Gustavo Adolfo Madero, Mexico City, Mexico, 07020
    - Novartis Investigative Site
  - Mexico City, Mexico City, Mexico, 06700
    - Novartis Investigative Site
  - Tlalpan, Mexico City, Mexico, 14050
    - Novartis Investigative Site
- Morelos
  - Cuernavaca, Morelos, Mexico, 62250
    - Novartis Investigative Site
- Nuevo León
  - Monterrey, Nuevo León, Mexico, 64020
    - Novartis Investigative Site
  - Monterrey, Nuevo León, Mexico, 64060
    - Novartis Investigative Site
  - Monterrey, Nuevo León, Mexico, 64440
    - Novartis Investigative Site
  - Monterrey, Nuevo León, Mexico, 64610
    - Novartis Investigative Site
- San Luis Potosí
  - San Luis Potosí City, San Luis Potosí, Mexico, 78200
    - Novartis Investigative Site
- Sinaloa
  - Culiacán, Sinaloa, Mexico, 80230
    - Novartis Investigative Site
  - Culiacán, Sinaloa, Mexico, 80200
    - Novartis Investigative Site
- Tamaulipas
  - Tampico, Tamaulipas, Mexico, 89440
    - Novartis Investigative Site
- Yucatán
  - Mérida, Yucatán, Mexico, 97070
    - Novartis Investigative Site
Netherlands
- - Ede, Netherlands, 6716 RP
    - Novartis Investigative Site
  - Eindhoven, Netherlands, 5623 EJ
    - Novartis Investigative Site
  - Enschede, Netherlands, 7512KZ
    - Novartis Investigative Site
  - Gouda, Netherlands, 2803 HH
    - Novartis Investigative Site
  - Hardenberg, Netherlands, 7770 SE
    - Novartis Investigative Site
  - Venlo, Netherlands, 5912 BL
    - Novartis Investigative Site
- Gelderland
  - Arnhem, Gelderland, Netherlands, 6815 AD
    - Novartis Investigative Site
  - Doetinchem, Gelderland, Netherlands, 7009 BL
    - Novartis Investigative Site
  - Nijmegen, Gelderland, Netherlands, 6500HB
    - Novartis Investigative Site
- Gerlderland
  - Nijmegen, Gerlderland, Netherlands, 6532 SZ
    - Novartis Investigative Site
- North Brabant
  - 's-Hertogenbosch, North Brabant, Netherlands, 5223 GZ
    - Novartis Investigative Site
  - Tilburg, North Brabant, Netherlands, 5042 AD
    - Novartis Investigative Site
- North Holland
  - Amsterdam, North Holland, Netherlands, 1090 HM
    - Novartis Investigative Site
  - Amsterdam, North Holland, Netherlands, 1105 AZ
    - Novartis Investigative Site
  - Beverwijk, North Holland, Netherlands, 1942 LE
    - Novartis Investigative Site
- Overijssel
  - Deventer, Overijssel, Netherlands, 7416 SE
    - Novartis Investigative Site
- Provincie Friesland
  - Leeuwarden, Provincie Friesland, Netherlands, 8934 AD
    - Novartis Investigative Site
  - Sneek, Provincie Friesland, Netherlands, 8601 ZK
    - Novartis Investigative Site
- South Holland
  - Delft, South Holland, Netherlands, 2625 AD
    - Novartis Investigative Site
  - Dirksland, South Holland, Netherlands, 3247 BW
    - Novartis Investigative Site
  - Dordrecht, South Holland, Netherlands, 3318 AT
    - Novartis Investigative Site
  - The Hague, South Holland, Netherlands, 2545 AA
    - Novartis Investigative Site
Philippines
- - Manila, Philippines, 1000
    - Novartis Investigative Site
  - Quezon, Philippines, 1102
    - Novartis Investigative Site
  - San Juan City, Philippines, 1502
    - Novartis Investigative Site
- Iloilo
  - Iloilo City, Iloilo, Philippines, 5000
    - Novartis Investigative Site
- National Capital Region
  - Manila, National Capital Region, Philippines, 1000
    - Novartis Investigative Site
Poland
- - Bialystok, Poland, 15-704
    - Novartis Investigative Site
  - Bydgoszcz, Poland, 85-065
    - Novartis Investigative Site
  - Bydgoszcz, Poland, 85-048
    - Novartis Investigative Site
  - Bygdoszcz, Poland, 85-605
    - Novartis Investigative Site
  - Chorzów, Poland, 41-500
    - Novartis Investigative Site
  - Elblag, Poland, 82-300
    - Novartis Investigative Site
  - Gdynia, Poland, 81-157
    - Novartis Investigative Site
  - Grudziądz, Poland, 86-300
    - Novartis Investigative Site
  - Katowice, Poland, 40-648
    - Novartis Investigative Site
  - Katowice, Poland, 40-081
    - Novartis Investigative Site
  - Katowice, Poland, 40-555
    - Novartis Investigative Site
  - Krakow, Poland, 31-501
    - Novartis Investigative Site
  - Krakow, Poland, 30-721
    - Novartis Investigative Site
  - Krakow, Poland, 31-216
    - Novartis Investigative Site
  - Lodz, Poland, 91-347
    - Novartis Investigative Site
  - Lodz, Poland, 91-034
    - Novartis Investigative Site
  - Myszków, Poland, 42-300
    - Novartis Investigative Site
  - Olsztyn, Poland, 10-165
    - Novartis Investigative Site
  - Piotrkow Trybunalski, Poland, 97-300
    - Novartis Investigative Site
  - Rzeszów, Poland, 35-055
    - Novartis Investigative Site
  - Tarnów, Poland, 33-100
    - Novartis Investigative Site
  - Torun, Poland, 87-100
    - Novartis Investigative Site
  - Warsaw, Poland, 00-215
    - Novartis Investigative Site
  - Wroclaw, Poland, 52-416
    - Novartis Investigative Site
  - Wroclaw, Poland, 53-673
    - Novartis Investigative Site
- Maloposkie
  - Krakow, Maloposkie, Poland, 31-271
    - Novartis Investigative Site
Portugal
- - Almada, Portugal, 2805-267
    - Novartis Investigative Site
  - Carnaxide, Portugal, 2799-523
    - Novartis Investigative Site
  - Coimbra, Portugal, 3004-561
    - Novartis Investigative Site
  - Lisbon, Portugal, 1500 650
    - Novartis Investigative Site
  - Lisbon, Portugal, 1649-035
    - Novartis Investigative Site
  - Matosinhos Municipality, Portugal, 4454-513
    - Novartis Investigative Site
  - Porto, Portugal, 4200 319
    - Novartis Investigative Site
  - Santa Maria da Feira, Portugal, 4520-211
    - Novartis Investigative Site
  - Setúbal, Portugal, 2910-549
    - Novartis Investigative Site
  - Vila Nova de Gaia, Portugal, 4434 502
    - Novartis Investigative Site
Puerto Rico
- - Ponce, Puerto Rico, 00717-1322
    - Research and Cardiovascular Corp
Romania
- - Brasov, Romania, 500283
    - Novartis Investigative Site
  - Brăila, Romania, 810325
    - Novartis Investigative Site
  - Bucharest, Romania, 022328
    - Novartis Investigative Site
  - Bucharest, Romania, 020475
    - Novartis Investigative Site
  - Bucharest, Romania, 011461
    - Novartis Investigative Site
  - Bucharest, Romania, 010496
    - Novartis Investigative Site
  - Bucharest, Romania, 010627
    - Novartis Investigative Site
  - Bucharest, Romania, 011055
    - Novartis Investigative Site
  - Bucharest, Romania, 021875
    - Novartis Investigative Site
  - Bucharest, Romania, 010192
    - Novartis Investigative Site
  - Cluj-Napoca, Romania, 400015
    - Novartis Investigative Site
  - Cluj-Napoca, Romania, 400001
    - Novartis Investigative Site
  - Iași, Romania, 700544
    - Novartis Investigative Site
  - Târgu Mureş, Romania, 540142
    - Novartis Investigative Site
  - Târgu Mureş, Romania, 540143
    - Novartis Investigative Site
- Argeş
  - Piteşti, Argeş, Romania, 110424
    - Novartis Investigative Site
- Bihor County
  - Oradea, Bihor County, Romania, 410001
    - Novartis Investigative Site
- Buzău
  - Buzău, Buzău, Romania, 120133
    - Novartis Investigative Site
- Cluj
  - Cluj-Napoca, Cluj, Romania, 400006
    - Novartis Investigative Site
- Dolj
  - Craiova, Dolj, Romania, 200513
    - Novartis Investigative Site
  - Craiova, Dolj, Romania, 200642
    - Novartis Investigative Site
- Dâmbovița County
  - Targoviste, Dâmbovița County, Romania, 130095
    - Novartis Investigative Site
- Ilfov
  - Afumaţi, Ilfov, Romania, 077010
    - Novartis Investigative Site
- Maramureş
  - Baia Mare, Maramureş, Romania, 430222
    - Novartis Investigative Site
  - Baia Mare, Maramureş, Romania, 430123
    - Novartis Investigative Site
- Mureș County
  - Târgu Mureş, Mureș County, Romania, 540124
    - Novartis Investigative Site
  - Târgu Mureş, Mureș County, Romania, 540136
    - Novartis Investigative Site
- Suceava
  - Suceava, Suceava, Romania, 720237
    - Novartis Investigative Site
- Timiș County
  - Timișoara, Timiș County, Romania, 300041
    - Novartis Investigative Site
  - Timișoara, Timiș County, Romania, 300480
    - Novartis Investigative Site
  - Timișoara, Timiș County, Romania, 300125
    - Novartis Investigative Site
  - Timișoara, Timiș County, Romania, 300362
    - Novartis Investigative Site
  - Timișoara, Timiș County, Romania, 300723
    - Novartis Investigative Site
Singapore
- - Singapore, Singapore, 119074
    - Novartis Investigative Site
  - Singapore, Singapore, 529889
    - Novartis Investigative Site
  - Singapore, Singapore, 169608
    - Novartis Investigative Site
- Singapore
  - Singapore, Singapore, Singapore, 768828
    - Novartis Investigative Site
Slovakia
- - Bardejov, Slovakia, 085 01
    - Novartis Investigative Site
  - Bratislava, Slovakia, 831 06
    - Novartis Investigative Site
  - Bratislava, Slovakia, 833 48
    - Novartis Investigative Site
  - Bratislava, Slovakia, 833 05
    - Novartis Investigative Site
  - Bratislava, Slovakia, 831 01
    - Novartis Investigative Site
  - Bratislava, Slovakia, 851 01
    - Novartis Investigative Site
  - Bratislava, Slovakia, 841 04
    - Novartis Investigative Site
  - Bratislava, Slovakia, 841 08
    - Novartis Investigative Site
  - Dolný Kubín, Slovakia, 026 01
    - Novartis Investigative Site
  - Košice, Slovakia, 040 01
    - Novartis Investigative Site
  - Košice, Slovakia, 040 11
    - Novartis Investigative Site
  - Kráľovský Chlmec, Slovakia, 077 01
    - Novartis Investigative Site
  - Lučenec, Slovakia, 984 01
    - Novartis Investigative Site
  - Malacky, Slovakia, 901 22
    - Novartis Investigative Site
  - Nitra, Slovakia, 949 01
    - Novartis Investigative Site
  - Nitra, Slovakia, 950 01
    - Novartis Investigative Site
  - Nitra, Slovakia, 949 11
    - Novartis Investigative Site
  - Nové Zámky, Slovakia, 940 01
    - Novartis Investigative Site
  - Prešov, Slovakia, 080 01
    - Novartis Investigative Site
  - Rožňava, Slovakia, 048 01
    - Novartis Investigative Site
  - Svidník, Slovakia, 089 01
    - Novartis Investigative Site
  - Trnava, Slovakia, 917 01
    - Novartis Investigative Site
  - Ľubochňa, Slovakia, 034 91
    - Novartis Investigative Site
  - Šamorín, Slovakia, 931 01
    - Novartis Investigative Site
- Slovak Republic
  - Lučenec, Slovak Republic, Slovakia, 984 01
    - Novartis Investigative Site
- Slovakia
  - Bratislava, Slovakia, Slovakia, 813 69
    - Novartis Investigative Site
South Africa
- - Cape Town, South Africa, 7531
    - Novartis Investigative Site
  - Pretoria, South Africa, 0181
    - Novartis Investigative Site
  - Western Cape, South Africa, 7130
    - Novartis Investigative Site
- Eastern Cape
  - Port Elizabeth, Eastern Cape, South Africa, 6001
    - Novartis Investigative Site
- Free State
  - Bloemfontein, Free State, South Africa, 9301
    - Novartis Investigative Site
- Gauteng
  - Pretoria, Gauteng, South Africa, 0184
    - Novartis Investigative Site
- KwaZulu-Natal
  - KwaDukuza, KwaZulu-Natal, South Africa, 4449
    - Novartis Investigative Site
- Western Cape
  - Cape Town, Western Cape, South Africa, 7500
    - Novartis Investigative Site
  - Cape Town, Western Cape, South Africa, 7530
    - Novartis Investigative Site
  - George, Western Cape, South Africa, 6529
    - Novartis Investigative Site
  - Somerset West, Western Cape, South Africa, 7130
    - Novartis Investigative Site
- ZAF
  - Cape Town, ZAF, South Africa, 7570
    - Novartis Investigative Site
Spain
- - A Coruña, Spain, 15006
    - Novartis Investigative Site
  - A Coruña, Spain, 15001
    - Novartis Investigative Site
  - Alicante, Spain, 03700
    - Novartis Investigative Site
  - Almería, Spain, 04009
    - Novartis Investigative Site
  - Barcelona, Spain, 08035
    - Novartis Investigative Site
  - Barcelona, Spain, 08041
    - Novartis Investigative Site
  - Barcelona, Spain, 08025
    - Novartis Investigative Site
  - Barcelona, Spain, 08022
    - Novartis Investigative Site
  - Barcelona, Spain, 08028
    - Novartis Investigative Site
  - Barcelona, Spain, 08023
    - Novartis Investigative Site
  - Córdoba, Spain, 14004
    - Novartis Investigative Site
  - Huelva, Spain, 21080
    - Novartis Investigative Site
  - Las Palmas GC, Spain, 35010
    - Novartis Investigative Site
  - Madrid, Spain, 28041
    - Novartis Investigative Site
  - Madrid, Spain, 28034
    - Novartis Investigative Site
  - Madrid, Spain, 28040
    - Novartis Investigative Site
  - Madrid, Spain, 28009
    - Novartis Investigative Site
  - Madrid, Spain, 28003
    - Novartis Investigative Site
  - Madrid, Spain, 28010
    - Novartis Investigative Site
  - Málaga, Spain, 29010
    - Novartis Investigative Site
  - Salamanca, Spain, 37007
    - Novartis Investigative Site
  - Seville, Spain, 41009
    - Novartis Investigative Site
  - Seville, Spain, 41013
    - Novartis Investigative Site
  - Tarragona, Spain, 43002
    - Novartis Investigative Site
  - Valencia, Spain, 46014
    - Novartis Investigative Site
  - Zaragoza, Spain, 50009
    - Novartis Investigative Site
- A Coruna
  - Ferrol, A Coruna, Spain, 15405
    - Novartis Investigative Site
  - Santiago, A Coruna, Spain, 15702
    - Novartis Investigative Site
  - Santiago Compostela, A Coruna, Spain, 15706
    - Novartis Investigative Site
- Alicante
  - Elche, Alicante, Spain, 03203
    - Novartis Investigative Site
- Andalusia
  - Granada, Andalusia, Spain, 18014
    - Novartis Investigative Site
  - Huelva, Andalusia, Spain, 21005
    - Novartis Investigative Site
  - Marbella, Andalusia, Spain, 29600
    - Novartis Investigative Site
  - Málaga, Andalusia, Spain, 29009
    - Novartis Investigative Site
- Balearic Islands
  - Mallorca, Balearic Islands, Spain, 07198
    - Novartis Investigative Site
  - Palma, Balearic Islands, Spain, 07011
    - Novartis Investigative Site
- Barcelona
  - Badalona, Barcelona, Spain, 08916
    - Novartis Investigative Site
  - Centelles, Barcelona, Spain, 08540
    - Novartis Investigative Site
  - La Roca del Vallès, Barcelona, Spain, 08430
    - Novartis Investigative Site
  - Mataró, Barcelona, Spain, 08303
    - Novartis Investigative Site
  - Sant Adrià de Besòs, Barcelona, Spain, 08930
    - Novartis Investigative Site
  - Vic, Barcelona, Spain, 08500
    - Novartis Investigative Site
  - el Prat de Llobregat, Barcelona, Spain, 08820
    - Novartis Investigative Site
- Cadiz
  - Puerto Real, Cadiz, Spain, 11510
    - Novartis Investigative Site
  - Sanlucar Barrameda, Cadiz, Spain, 11540
    - Novartis Investigative Site
  - Villamartín, Cadiz, Spain, 11650
    - Novartis Investigative Site
- Cantabria
  - Santander, Cantabria, Spain, 39008
    - Novartis Investigative Site
- Catalonia
  - Barcelona, Catalonia, Spain, 08003
    - Novartis Investigative Site
- Extremadura
  - Cáceres, Extremadura, Spain, 10003
    - Novartis Investigative Site
- Girona
  - Peralada, Girona, Spain, 17491
    - Novartis Investigative Site
- Las Palmas
  - Las Palmas de Gran C, Las Palmas, Spain, 35016
    - Novartis Investigative Site
- Madrid
  - Boadilla del Monte, Madrid, Spain, 28660
    - Novartis Investigative Site
  - Fuenlabrada, Madrid, Spain, 28942
    - Novartis Investigative Site
  - Pozuelo de Alarcón, Madrid, Spain, 28223
    - Novartis Investigative Site
- Malaga
  - Antequera, Malaga, Spain, 29200
    - Novartis Investigative Site
  - Ronda, Malaga, Spain, 29400
    - Novartis Investigative Site
- Murcia
  - El Palmar, Murcia, Spain, 30120
    - Novartis Investigative Site
- Navarre
  - Pamplona, Navarre, Spain, 31008
    - Novartis Investigative Site
- Santa Cruz De Tenerife
  - San Cristóbal de La Laguna, Santa Cruz De Tenerife, Spain, 38320
    - Novartis Investigative Site
- Sevilla
  - Castilleja de la Cuesta, Sevilla, Spain, 41950
    - Novartis Investigative Site
  - Lebrija, Sevilla, Spain, 41570
    - Novartis Investigative Site
  - Utrera, Sevilla, Spain, 41710
    - Novartis Investigative Site
- Tarragona
  - Reus, Tarragona, Spain, 43201
    - Novartis Investigative Site
- Valencia
  - Alzira, Valencia, Spain, 46600
    - Novartis Investigative Site
Sweden
- - Gothenburg, Sweden, 405 45
    - Novartis Investigative Site
  - Linköping, Sweden, 582 13
    - Novartis Investigative Site
  - Lund, Sweden, 222 21
    - Novartis Investigative Site
  - Solna, Sweden, 171 64
    - Novartis Investigative Site
  - Stockholm, Sweden, 111 57
    - Novartis Investigative Site
  - Uppsala, Sweden, 75237
    - Novartis Investigative Site
  - Västerås, Sweden, 721 89
    - Novartis Investigative Site
Switzerland
- - Basel, Switzerland, 4031
    - Novartis Investigative Site
  - Bern, Switzerland, 3010
    - Novartis Investigative Site
  - Geneva, Switzerland, 1211
    - Novartis Investigative Site
  - Lucerne, Switzerland, 6000
    - Novartis Investigative Site
  - Lugano, Switzerland, 6900
    - Novartis Investigative Site
Taiwan
- - Changhua, Taiwan, 50006
    - Novartis Investigative Site
  - Kaohsiung City, Taiwan, 80756
    - Novartis Investigative Site
  - Taichung, Taiwan, 40447
    - Novartis Investigative Site
  - Tainan, Taiwan, 704
    - Novartis Investigative Site
  - Tainan, Taiwan, 71004
    - Novartis Investigative Site
  - Taipei, Taiwan, 11217
    - Novartis Investigative Site
  - Taipei, Taiwan, 110
    - Novartis Investigative Site
  - Taoyuan, Taiwan, 33305
    - Novartis Investigative Site
- Taiwan ROC
  - Taichung, Taiwan ROC, Taiwan, 40201
    - Novartis Investigative Site
Thailand
- - Bangkok, Thailand, 10330
    - Novartis Investigative Site
  - Bangkok, Thailand, 10700
    - Novartis Investigative Site
  - Bangkok, Thailand, 10400
    - Novartis Investigative Site
  - Chiang Mai, Thailand, 50200
    - Novartis Investigative Site
- Hat Yai
  - Songkhla, Hat Yai, Thailand, 90110
    - Novartis Investigative Site
- THA
  - Khon Kaen, THA, Thailand, 40002
    - Novartis Investigative Site
- Thailand
  - Muang, Thailand, Thailand, 12120
    - Novartis Investigative Site
Turkey (Türkiye)
- - Izmir, Turkey (Türkiye), 35100
    - Novartis Investigative Site
- Balcova
  - Izmir, Balcova, Turkey (Türkiye), 35340
    - Novartis Investigative Site
- Bayrakli
  - Izmir, Bayrakli, Turkey (Türkiye), 35540
    - Novartis Investigative Site
- Bilkent-Cankaya
  - Ankara, Bilkent-Cankaya, Turkey (Türkiye), 6800
    - Novartis Investigative Site
- Fatih
  - Istanbul, Fatih, Turkey (Türkiye), 34098
    - Novartis Investigative Site
- Kadikoy
  - Istanbul, Kadikoy, Turkey (Türkiye), 34668
    - Novartis Investigative Site
- Kinikli
  - Denizli, Kinikli, Turkey (Türkiye), 20070
    - Novartis Investigative Site
- Kucukcekmece
  - Istanbul, Kucukcekmece, Turkey (Türkiye), 34303
    - Novartis Investigative Site
- Melikgazi
  - Kayseri, Melikgazi, Turkey (Türkiye), 38039
    - Novartis Investigative Site
- Mentese
  - Muğla, Mentese, Turkey (Türkiye), 48000
    - Novartis Investigative Site
- Odunpazari
  - Eskişehir, Odunpazari, Turkey (Türkiye), 26040
    - Novartis Investigative Site
- Sehitkamil
  - Gaziantep, Sehitkamil, Turkey (Türkiye), 27310
    - Novartis Investigative Site
- Sihhiye-Altindag
  - Ankara, Sihhiye-Altindag, Turkey (Türkiye), 06230
    - Novartis Investigative Site
- Yenisehir
  - Mersin, Yenisehir, Turkey (Türkiye), 33110
    - Novartis Investigative Site
- Zeytinburnu
  - Istanbul, Zeytinburnu, Turkey (Türkiye), 34010
    - Novartis Investigative Site
United Kingdom
- - Belfast, United Kingdom, BT16 1RH
    - Novartis Investigative Site
  - Belfast, United Kingdom, BT2 8BG
    - Novartis Investigative Site
  - Birmingham, United Kingdom, B21 9RY
    - Novartis Investigative Site
  - Blackpool, United Kingdom, FY3 8NR
    - Novartis Investigative Site
  - Bristol, United Kingdom, BS2 8HW
    - Novartis Investigative Site
  - Cardiff, United Kingdom, CF64 2XX
    - Novartis Investigative Site
  - Chesterfield, United Kingdom, S40 4AA
    - Novartis Investigative Site
  - Denbighshire, United Kingdom, LL18 1DA
    - Novartis Investigative Site
  - Edinburgh, United Kingdom, EH16 4SA
    - Novartis Investigative Site
  - Glasgow, United Kingdom, G20 7BE
    - Novartis Investigative Site
  - Kettering, United Kingdom, NN16 8UZ
    - Novartis Investigative Site
  - Lancashire, United Kingdom, FY4 3AD
    - Novartis Investigative Site
  - London, United Kingdom, W12 0HS
    - Novartis Investigative Site
  - Londonderry, United Kingdom, BT47 6SB
    - Novartis Investigative Site
  - Middlesex, United Kingdom, TW7 6AF
    - Novartis Investigative Site
  - Norwich, United Kingdom, NR4 7UY
    - Novartis Investigative Site
  - Plymouth, United Kingdom, PL5 3JB
    - Novartis Investigative Site
  - Plympton, United Kingdom, PL7 2QP
    - Novartis Investigative Site
  - Rhyl, United Kingdom, LL18 5UJ
    - Novartis Investigative Site
  - Salford, United Kingdom, M6 8HD
    - Novartis Investigative Site
  - Scunthorpe, United Kingdom, DN15 7BH
    - Novartis Investigative Site
  - Sheffield, United Kingdom, S5 7AU
    - Novartis Investigative Site
  - Tyne and Wear, United Kingdom, NE29 8NH
    - Novartis Investigative Site
  - Wiltshire, United Kingdom, SN15 2SB
    - Novartis Investigative Site
  - Wirrel, United Kingdom, CH62 6EE
    - Novartis Investigative Site
  - Wrexham, United Kingdom, LL13 7TD
    - Novartis Investigative Site
- Beds
  - Luton, Beds, United Kingdom, LU4 0DZ
    - Novartis Investigative Site
- Buckinghamshire
  - High Wycombe, Buckinghamshire, United Kingdom, HP11 2TT
    - Novartis Investigative Site
- Cambridgeshire
  - Peterborough, Cambridgeshire, United Kingdom, PE3 9GZ
    - Novartis Investigative Site
- Cornwall
  - Connor Downs, Cornwall, United Kingdom, TR27 5DT
    - Novartis Investigative Site
  - Fowey, Cornwall, United Kingdom, PL23 1DT
    - Novartis Investigative Site
  - Liskeard, Cornwall, United Kingdom, PL14 3XA
    - Novartis Investigative Site
  - Newquay, Cornwall, United Kingdom, TR7 1RU
    - Novartis Investigative Site
- Devon
  - Exeter, Devon, United Kingdom, EX2 5DW
    - Novartis Investigative Site
- Dorset
  - Dorchester, Dorset, United Kingdom, DT1 2JY
    - Novartis Investigative Site
- GBR
  - London, GBR, United Kingdom, EC1M 6BQ
    - Novartis Investigative Site
- Middlesex
  - Harrow, Middlesex, United Kingdom, HA1 3UJ
    - Novartis Investigative Site
- Northamptonshire
  - Corby, Northamptonshire, United Kingdom, NN17 2UR
    - Novartis Investigative Site
- Nothern Ireland
  - Portadown, Nothern Ireland, United Kingdom, BT63 5QQ
    - Novartis Investigative Site
- Peterborough
  - Wansford, Peterborough, United Kingdom, PE8 6PL
    - Novartis Investigative Site
- South Gloucestershire
  - Bristol, South Gloucestershire, United Kingdom, BS37 4AX
    - Novartis Investigative Site
- Stockton on Tees
  - Hardwick, Stockton on Tees, United Kingdom, TS19 8PE
    - Novartis Investigative Site
- Suffolk
  - Bury St Edmunds, Suffolk, United Kingdom, IP33 2QZ
    - Novartis Investigative Site
- Wales
  - Cardiff, Wales, United Kingdom, CF5 4AD
    - Novartis Investigative Site
  - Cardiff, Wales, United Kingdom, CF23 9PN
    - Novartis Investigative Site
United States
- Alabama
  - Birmingham, Alabama, United States, 35209
    - Central Alabama Research
  - Birmingham, Alabama, United States, 35211
    - UAB St Vincents
  - Fairhope, Alabama, United States, 36532
    - Eastern Shore Research Institute
  - Foley, Alabama, United States, 36535
    - G and L Research LLC
  - Huntsville, Alabama, United States, 35801
    - Longwood Research
  - Mobile, Alabama, United States, 36608
    - CB Flock Corporation
  - Saraland, Alabama, United States, 36571
    - The Center for Clinical Trials
- Arizona
  - Glendale, Arizona, United States, 85308
    - Lenzmeier Family Practice
  - Glendale, Arizona, United States, 85306
    - Synexus
  - Sun City West, Arizona, United States, 85375
    - Clinical Research Inst of Arizona
  - Tempe, Arizona, United States, 85283
    - Clinical Research Advantage Fiel Family and Sports Med, PC
  - Tucson, Arizona, United States, 85741
    - Synexus Clinical Research US Inc
- California
  - Beverly Hills, California, United States, 90211
    - National Heart Institute
  - Beverly Hills, California, United States, 90210
    - Cardiovascular Res Found
  - Canoga Park, California, United States, 91303
    - Alliance Clinical
  - Chino, California, United States, 91710
    - Inland Psychiatric Medical Group
  - Covina, California, United States, 91723
    - Valley Clinical Trials Inc
  - Los Angeles, California, United States, 90033
    - Keck Medical Center USC
  - Los Angeles, California, United States, 90059
    - Charles R Drew University of Medicine and Science
  - Newhall, California, United States, 91321
    - C for Endo Diabetes and MD
  - Northridge, California, United States, 91325
    - Valley Clinical Trials
  - Northridge, California, United States, 91324
    - California Medical Research Associates Inc
  - Palo Alto, California, United States, 94304
    - Stanford University Medical Center
  - Sacramento, California, United States, 95841
    - Cordova Clinical Research
  - Sacramento, California, United States, 95821-2134
    - Clinical Trials Research Sacramento
  - San Diego, California, United States, 92123
    - San Diego Cardiac Center
  - San Diego, California, United States, 92120
    - Acclaim Clinical Research
  - San Diego, California, United States, 92103
    - University of California San Diego
  - San Diego, California, United States, 92108
    - Kaiser Permanente San Diego
  - Spring Valley, California, United States, 91978
    - Encompass Clinical Research
  - Torrance, California, United States, 90502
    - Harbor UCLA Medical Center
  - Ventura, California, United States, 93003
    - Cardiology Associates Medical Group
  - Vista, California, United States, 92081
    - Blue Coast Research Center LLC
  - West Hills, California, United States, 91307
    - Interv Cardiology Med Grp
- Colorado
  - Littleton, Colorado, United States, 80120
    - South Denver Cardiology Associates PC
- Connecticut
  - Stamford, Connecticut, United States, 06905
    - Cardiology Ass of Fairfield County
  - Waterbury, Connecticut, United States, 06708
    - Chase Medical Research LLC
- Florida
  - Boca Raton, Florida, United States, 33434
    - Excel Medical Clinical Trials LLC
  - Bradenton, Florida, United States, 34209
    - Nova Clinical Research LLC
  - Clearwater, Florida, United States, 33761
    - Tampa Bay Medical Research
  - Clearwater, Florida, United States, 33756
    - Clearwater Cardiovascular and Interventional Consultants
  - Clearwater, Florida, United States, 33756
    - Bay Care Medical Group
  - Daytona Beach, Florida, United States, 32117
    - Cardiology Research Associates
  - DeLand, Florida, United States, 32720
    - Hillcrest Medical Research
  - Delray Beach, Florida, United States, 33445
    - Personal Physicians Care
  - Fleming Island, Florida, United States, 32003
    - Fleming Island Ctr Clinical Res.
  - Fort Lauderdale, Florida, United States, 33308
    - Proactive Clinical Research
  - Hialeah, Florida, United States, 33010
    - Qway Research
  - Hialeah, Florida, United States, 33012
    - Indago Research and Health Ctr Inc
  - Hialeah, Florida, United States, 33013
    - Sister Life Research Inc
  - Hollywood, Florida, United States, 33021
    - Center for Diabetes and Endocrine Care
  - Hollywood, Florida, United States, 33021
    - Zenith Clinical Research
  - Hollywood, Florida, United States, 33024
    - Encore Medical Research
  - Hollywood, Florida, United States, 33021
    - South Florida Rsrch Solutions LLC
  - Jacksonville, Florida, United States, 32216
    - East Coast Institute for Research
  - Jacksonville, Florida, United States, 32209
    - UF Health Science Center
  - Miami, Florida, United States, 33126
    - Finlay Medical Research
  - Miami, Florida, United States, 33133
    - Infinite Clinical Research
  - Miami, Florida, United States, 33125
    - Columbus Clinical Services LLC
  - Miami, Florida, United States, 33156
    - International Research Associates LLC
  - Miami, Florida, United States, 33186
    - A&A Research Group Inc
  - Miami, Florida, United States, 33135
    - Springs Medical And Research
  - Miami, Florida, United States, 33144
    - L and C Professional Medical Institute
  - Miami, Florida, United States, 33155
    - Regenerate Clinical Trial
  - Miami Gardens, Florida, United States, 33014
    - Meridian International Research
  - Miami Lakes, Florida, United States, 33014
    - Inpatient Research Clinical LLC
  - Miami Lakes, Florida, United States, 33014
    - RM Medical Research Inc
  - Miramar, Florida, United States, 33027
    - FXM Clin Res Miramar LLC
  - Orlando, Florida, United States, 32803
    - Advent Health Orlando
  - Palm Springs, Florida, United States, 33406
    - CTMD Research
  - Pembroke Pines, Florida, United States, 33029
    - DBC Research USA
  - Plant City, Florida, United States, 33563
    - Fam Medical Specialists Of Fl Plc
  - Ponte Vedra, Florida, United States, 32801
    - St Johns Center
  - Port Charlotte, Florida, United States, 33952
    - Peace River Cardiovascular Center
  - Saint Augustine, Florida, United States, 32086
    - East Coast Inst for Research LLC
  - Sarasota, Florida, United States, 34239
    - Cardiovascular Center Of Sarasota
  - St. Petersburg, Florida, United States, 33713
    - Advanced Medical Research Center
  - Tampa, Florida, United States, 33612
    - James A Haley Veterans Hospital
  - Tampa, Florida, United States, 33705
    - BayCare Health System
  - Wellington, Florida, United States, 33449
    - Cardiology Partners Clinical Research Institute
  - Winter Park, Florida, United States, 32789
    - Flourish Research
- Georgia
  - Canton, Georgia, United States, 30114
    - East Coast Research
  - Fayetteville, Georgia, United States, 30214
    - Javara Research
  - Macon, Georgia, United States, 31210
    - The Jones Center For Diabetes And Endocrine Wellness
  - Tucker, Georgia, United States, 30084
    - Atlanta Heart Specialists LLC
- Hawaii
  - Honolulu, Hawaii, United States, 96814
    - East West Research Institute
- Idaho
  - Sandpoint, Idaho, United States, 83864
    - Kootenai Heart Clinic-Sandpoint
- Illinois
  - Arlington Heights, Illinois, United States, 60005
    - Endeavor Health Clinical Op- NCH
  - Chicago, Illinois, United States, 60612
    - University of Illinois at Chicago
  - Chicago, Illinois, United States, 60607
    - Chicago Clinical Research Inst
  - Peoria, Illinois, United States, 61602
    - Cardiovascular Services
- Indiana
  - Elkhart, Indiana, United States, 46514
    - Beacon Health System
  - Indianapolis, Indiana, United States, 46237
    - Franciscan Health Services Research Center
  - Valparaiso, Indiana, United States, 46383
    - Buynak Clinical Research PC
- Iowa
  - Council Bluffs, Iowa, United States, 51501
    - West Broadway Clinic
- Kansas
  - Hutchinson, Kansas, United States, 67502
    - Hutchinson Clinic
  - Topeka, Kansas, United States, 66606
    - Cotton O Neil Clinical Res Center
  - Wichita, Kansas, United States, 67214
    - Kansas Nephrology Research Institute LLC
- Kentucky
  - Bowling Green, Kentucky, United States, 42101
    - Graves Gilbert Clinic
  - Lexington, Kentucky, United States, 40503
    - The Research Group
  - Owensboro, Kentucky, United States, 42303
    - Research Integrity LLC
- Louisiana
  - Covington, Louisiana, United States, 70433
    - Cardiovascular Associates Research
  - Covington, Louisiana, United States, 70433
    - Louisiana Heart Center Research
  - Crowley, Louisiana, United States, 70526
    - Avant Research Associates LLC
  - Mandeville, Louisiana, United States, 70448
    - North Shore Heart and Vascular
  - Marrero, Louisiana, United States, 70072
    - Bethesda Medical Clinic
  - Metairie, Louisiana, United States, 70006
    - Omega Clinical Research
  - Metairie, Louisiana, United States, 70006
    - NOLA Care Clinical Research
  - Opelousas, Louisiana, United States, 70570
    - CV Ins of the South
  - Shreveport, Louisiana, United States, 71103
    - Cardiovascular Solutions LLC
  - Slidell, Louisiana, United States, 70458
    - Louisiana Heart Center Research
  - West Monroe, Louisiana, United States, 71291
    - Monroe Research Llc
  - Zachary, Louisiana, United States, 70791
    - Southern Clinical Research
- Maine
  - Bangor, Maine, United States, 04401
    - Northeast Cardiology Associates
- Maryland
  - Baltimore, Maryland, United States, 21229
    - Ascension Saint Agnes Heart Care
  - Beltsville, Maryland, United States, 20705
    - Metropolitan Cardiovascular Consultants Llc
  - Columbia, Maryland, United States, 21044
    - Johns Hopkins University
  - Ft. Washington, Maryland, United States, 20744
    - Anderson Medical Research
  - Lanham, Maryland, United States, 20706
    - Capitol Cardiology Associates
- Massachusetts
  - Boston, Massachusetts, United States, 02114 2696
    - MGH
  - Worcester, Massachusetts, United States, 01655
    - UMass Memorial Medical Center
- Michigan
  - Detroit, Michigan, United States, 48202
    - Henry Ford Hospital
  - Flint, Michigan, United States, 48504
    - AA Medical Research Center
  - Midland, Michigan, United States, 48670
    - MyMichigan Medical Center Midland
  - Saginaw, Michigan, United States, 48601
    - Central Michigan University
  - Troy, Michigan, United States, 48098
    - Troy Internal Medicine Research
  - Ypsilanti, Michigan, United States, 48197
    - Trinity Health Michigan Heart
- Minnesota
  - Duluth, Minnesota, United States, 55805
    - Essentia Health
  - Minneapolis, Minnesota, United States, 55407-3799
    - Abbott Northwestern Hospital
  - Richfield, Minnesota, United States, 55432
    - Synexus Clinical Research US Inc
  - Saint Louis Park, Minnesota, United States, 55416
    - Park Nicollet Institute
  - Saint Paul, Minnesota, United States, 55103
    - Fairview Health Services
- Mississippi
  - Jackson, Mississippi, United States, 39216
    - Jackson Heart Clinic
  - Jackson, Mississippi, United States, 39216
    - VAMC Research-G V Sonny Montgomery Clinic
  - Jackson, Mississippi, United States, 39202
    - Elite Clinical Research LLC
  - Port Gibson, Mississippi, United States, 39150
    - David M Headley Clinic
  - Tupelo, Mississippi, United States, 38801
    - Cardiology Associates of North MS
- Missouri
  - City of Saint Peters, Missouri, United States, 63303
    - StudyMetrix Research
  - Kansas City, Missouri, United States, 64128
    - Kansas City VA Medical Center
  - St Louis, Missouri, United States, 63125-4181
    - St Louis V A Medical Center
  - St Louis, Missouri, United States, 63110
    - Barnes Jewish Hosp-Washington Univ
  - St Louis, Missouri, United States, 63136
    - St Louis Heart and Vascular
  - St Louis, Missouri, United States, 63141
    - Synexus Clinical Research US Inc
- Montana
  - Butte, Montana, United States, 59701
    - Mercury Street Medical
- Nebraska
  - Lincoln, Nebraska, United States, 68516
    - Lincoln Internal Medicine Associates
  - Lincoln, Nebraska, United States, 68510
    - Nebraska Heart Institute
  - Omaha, Nebraska, United States, 68130
    - CCT Research
  - Omaha, Nebraska, United States, 68198
    - University of Nebraska Med Center
- Nevada
  - Henderson, Nevada, United States, 89074
    - Las Vegas Endocrinology
  - Las Vegas, Nevada, United States, 89119
    - AB Clinical Trials
  - Las Vegas, Nevada, United States, 89121
    - Clinical Research of South Nevada
- New Jersey
  - Bridgewater, New Jersey, United States, 08807
    - Advanced Heart Care
  - Elmer, New Jersey, United States, 08318
    - Cardiovas Assoc of Delaware Valley
  - Linden, New Jersey, United States, 07036
    - New Jersey Heart
- New York
  - Albany, New York, United States, 12211
    - Capital Cardiology Associates
  - Albany, New York, United States, 12206
    - Albany Medical College
  - Flushing, New York, United States, 11355
    - New York Presbyterian Queens
  - New Windsor, New York, United States, 12553
    - Mid Hudson Medical Research PLLC
  - Poughkeepsie, New York, United States, 12601
    - Hudson Valley Urology
  - Rochester, New York, United States, 14609
    - Rochester Clinical Research
  - The Bronx, New York, United States, 10468
    - Clinical Research Advantage
  - Valhalla, New York, United States, 10595
    - Westchester Medical Center
  - Westfield, New York, United States, 14787
    - Great Lakes Medical Research
- North Carolina
  - Cary, North Carolina, United States, 27511
    - Cary Research Group
  - Greensboro, North Carolina, United States, 27401
    - Moses Cone Hospital
  - Greensboro, North Carolina, United States, 27405
    - Medication Management LLC
  - Mount Airy, North Carolina, United States, 27030
    - IMA Research
  - Raleigh, North Carolina, United States, 27609
    - Multispecialty Research Ass Of NC
  - Statesville, North Carolina, United States, 28625
    - Accellacare
  - Wilmington, North Carolina, United States, 28401
    - Adv Imaging Prev and Clin Research
  - Winston-Salem, North Carolina, United States, 27157
    - Wake Forest University Baptist Medical Center
- North Dakota
  - Fargo, North Dakota, United States, 58103
    - Lillestol Research LLC
  - Grand Forks, North Dakota, United States, 58201
    - Altru Health Research Dept.
- Ohio
  - Canton, Ohio, United States, 44710
    - Aultman Hospital
  - Cincinnati, Ohio, United States, 45236
    - Synexus Clinical Research US Inc
  - Columbus, Ohio, United States, 43212
    - Synexus Clinical Research
  - Dayton, Ohio, United States, 45429
    - Primed Clinical Research
  - Dayton, Ohio, United States, 45439
    - Providence Medical Group
  - Lima, Ohio, United States, 45801
    - NexGen Research
  - Marion, Ohio, United States, 43302
    - Rama Research LLC
  - Springfield, Ohio, United States, 45504
    - Heart House Research Foundation
- Oklahoma
  - Oklahoma City, Oklahoma, United States, 73112
    - Lynn Health Science Institute
  - Oklahoma City, Oklahoma, United States, 73135
    - South Oklahoma Heart Research LLC
- Pennsylvania
  - Horsham, Pennsylvania, United States, 19044
    - CCT Hatboro Medical Associates
  - Newport, Pennsylvania, United States, 17074
    - Capital Area Research LLC
  - Pittsburgh, Pennsylvania, United States, 15212
    - Allegheny General Hospital
  - Smithfield, Pennsylvania, United States, 15478
    - Frontier Clinical Research LLC
- Rhode Island
  - Warwick, Rhode Island, United States, 02886
    - Care Access
- South Carolina
  - Columbia, South Carolina, United States, 29209
    - Columbia VA Health Care System
  - Greenville, South Carolina, United States, 29607
    - Bon Secours Medical Group
  - Greer, South Carolina, United States, 29651
    - TRIBE Clinical Research
  - Ladson, South Carolina, United States, 29465
    - Trident Cardiology
  - Little River, South Carolina, United States, 29566
    - Main Street Physicians Care
- South Dakota
  - Rapid City, South Dakota, United States, 57701
    - Monument Health Clinical Research
  - Rapid City, South Dakota, United States, 57701
    - Care Access Research
- Tennessee
  - Greenville, Tennessee, United States, 37745
    - Wellmont CVA Heart Institute
  - Jackson, Tennessee, United States, 38301
    - Apex Cardiology Research Associates of Jackson
  - Kingsport, Tennessee, United States, 37660
    - Holston Medical Group
  - Knoxville, Tennessee, United States, 37909
    - New Phase Research And Development
  - Knoxville, Tennessee, United States, 37938
    - Accellacare
  - Powell, Tennessee, United States, 37849
    - Cardiovascular Res of Knoxville LLC
  - Tullahoma, Tennessee, United States, 37388
    - Tennessee Center For Clinical Trials
- Texas
  - Amarillo, Texas, United States, 79106
    - Pharma Tex Research
  - Amarillo, Texas, United States, 79124
    - Amarillo Heart Clin Rsh Inst
  - Bedford, Texas, United States, 76021
    - North Hills Medical Research Inc
  - Cypress, Texas, United States, 77429
    - Clinical Research Solution
  - Dallas, Texas, United States, 75216
    - VA North Texas Health Care System
  - Dallas, Texas, United States, 75230
    - Zenos Clinical Research
  - Dallas, Texas, United States, 75235
    - SW Family Medicine Associates
  - El Paso, Texas, United States, 79905
    - David Turbay MD PLLC
  - Fort Worth, Texas, United States, 76107
    - Texas Health Physicians Group
  - Houston, Texas, United States, 77024
    - PrimeCare Medical Group
  - Houston, Texas, United States, 77002
    - East Texas Cardiology PA
  - Houston, Texas, United States, 77070
    - Northwest Houston Cardiology PA
  - Houston, Texas, United States, 77079
    - MedCare Pharma LLC
  - Houston, Texas, United States, 77084
    - Dallas Heart and Vascular Consultants PA
  - Kingwood, Texas, United States, 77339
    - Texas Cardiology Assocs Of Houston
  - Lewisville, Texas, United States, 75057
    - Epic Clinical Research
  - Livingston, Texas, United States, 77351
    - East Texas Research Associates Inc.
  - McAllen, Texas, United States, 78504
    - Doctors Hospital at Renaissance
  - Red Oak, Texas, United States, 75154
    - Epic Medical Research
  - San Antonio, Texas, United States, 78233
    - Northeast Clinical Research of San Antonio LLC
  - Shavano Park, Texas, United States, 78231
    - Consano Clinical Research LLC
  - Stephenville, Texas, United States, 76401
    - Javara Research
  - Sugarland, Texas, United States, 77478
    - NRG Wellness Center
  - Tomball, Texas, United States, 77375
    - Northwest Houston Clinical Research PLLC
  - Weslaco, Texas, United States, 78596
    - Comprehensive Center
- Utah
  - Murray, Utah, United States, 84107
    - Intermountain Medical Center
  - Sandy City, Utah, United States, 84093
    - Diabetes And Endocrine Specialists
- Virginia
  - Burke, Virginia, United States, 22015
    - Burke Internal Medicine and Research
  - Falls Church, Virginia, United States, 22042
    - Virginia Heart
  - Hopewell, Virginia, United States, 23860
    - Heart Care Associates P C
  - Manassas, Virginia, United States, 20110
    - Manassas Clinical Research Center
  - Manassas, Virginia, United States, 20109
    - Carient Heart and Vascular
  - Richmond, Virginia, United States, 23298-0111
    - Virginia Commonwealth University
  - Roanoke, Virginia, United States, 24014
    - Roanoke Heart Institute
  - Suffolk, Virginia, United States, 23435
    - Centricity Research Suffolk Fam Med
- Washington
  - Puyallup, Washington, United States, 98372
    - MultiCare Ins Research Innovation
  - Tacoma, Washington, United States, 98405
    - Universal Research Group LLC
  - Wenatchee, Washington, United States, 98801
    - Confluence Health Hospital
- West Virginia
  - Morgantown, West Virginia, United States, 26506
    - West Virginia University Hospital
- Wisconsin
  - Milwaukee, Wisconsin, United States, 53215
    - Midwest Endocrinology Associates
  - Wausau, Wisconsin, United States, 54401
    - Cardiovascular Research and Education Foundation Inc
Vietnam
- - Hanoi, Vietnam, 100000
    - Novartis Investigative Site
  - Ho Chi Minh City, Vietnam, 700000
    - Novartis Investigative Site

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

40 years to 79 years (Adult, Older Adult)

Accepts Healthy Volunteers

Description

Inclusion Criteria:

At an increased risk for a first MACE (i.e., no prior major ASCVD event), defined as any one of the following:
1. Evidence of atherosclerotic coronary artery disease (CAD) on computer tomography (CT) or invasive coronary angiogram defined as a coronary artery stenosis ≥20% but <50% in the left main coronary artery or stenosis ≥20% but <70% in any other major epicardial coronary artery, or
2. Coronary artery calcium (CAC) score obtained by CT-scan ≥100 Agatston units, or
3. High 10-year ASCVD risk ≥20%, or
4. Intermediate 10-year ASCVD risk 7.5% - <20% with at least 2 risk-enhancing factors.
LDL-C ≥70 mg/dL (≥1.81 mmol/L) but <190 mg/dL (<4.91 mmol/L) at the screening visit. If on a background lipid lowering therapy, the dose should be stable for at least 4 weeks prior to the screening visit and the participant should be willing to remain on this background therapy for the entire duration of the study.

Exclusion Criteria:

History of major ASCVD event.
History of, or planned, ischemia-driven revascularization in a coronary or extracoronary arterial bed prior to randomization
Absence of coronary atherosclerosis on a CT angiogram or an invasive coronary angiogram in the 2 years prior to randomization
Coronary artery calcium (CAC) score of 0 obtained in the 2 years prior to randomization
Active liver disease or hepatic dysfunction
Previous, current, or planned treatment with a monoclonal antibody (mAb) directed toward proprotein convertase subtilisin/kexin type 9 (PCSK9) (e.g., evolocumab, alirocumab)
Pregnant or nursing (lactating) women
Women of childbearing potential unless they are using effective methods of contraception while taking study treatment which includes for 6 months after last study drug administration

Other protocol-defined inclusion/exclusion criteria may apply.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Quadruple

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: Placebo Matching placebo in 1.5ml pre-filled syringe. Randomized in a 1:1 ratio with Inclisiran.	Drug: Placebo in 1.5ml Matching placebo in 1.5ml solution for injection
Experimental: Inclisiran sodium 300mg Inclisiran sodium 300 mg in 1.5 mL solution for injection (subcutaneous) in pre-filled syringe. Randomized in a 1:1 ratio with matching placebo	Drug: Inclisiran sodium 300 mg (equivalent to 284 mg inclisiran) in 1.5 mL Subcutaneous injection in pre-filled syringe. Other Names: KJX839

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time to the first occurrence of 4P-MACE Time Frame: Time to the first occurrence of 4P-MACE (up to approximately 75 months)	4-Point-Major Adverse Cardiovascular Events (4P-MACE): composite of cardiovascular death, non-fatal myocardial infarction, non-fatal ischemic stroke, and urgent coronary revascularization.	Time to the first occurrence of 4P-MACE (up to approximately 75 months)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time to the first occurrence of 3P-MACE Time Frame: Time to the first occurrence of 3P-MACE (up to approximately 75 months)	3-Point-Major Adverse Cardiovascular Events (3P-MACE): composite of cardiovascular death, non-fatal myocardial infarction, and non-fatal ischemic stroke)	Time to the first occurrence of 3P-MACE (up to approximately 75 months)
Total number of first or repeated CV events (4P MACE) Time Frame: up to 75 months	Total 4P-MACE (composite of cardiovascular death, non-fatal myocardial infarction, non-fatal ischemic stroke, and urgent coronary revascularization)	up to 75 months
Total number of first or repeated CV events (3P MACE) Time Frame: up to 75 months	Total 3P-MACE (composite of cardiovascular death, non-fatal myocardial infarction, and non-fatal ischemic stroke)	up to 75 months
Time to occurrence of Cardiovascular death Time Frame: Time to Cardiovascular death (up to 75 months)	CV death is defined as death due to cardiovascular events.	Time to Cardiovascular death (up to 75 months)
Time to occurrence of death due to any reason Time Frame: Time to all-cause mortality (up to 75 months)	All-cause mortality is death due to any reason.	Time to all-cause mortality (up to 75 months)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Novartis Pharmaceuticals

Investigators

Study Director: Novartis Pharmaceuticals, Novartis Pharmaceuticals

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 9, 2023

Primary Completion (Estimated)

April 16, 2029

Study Completion (Estimated)

April 16, 2029

Study Registration Dates

First Submitted

February 13, 2023

First Submitted That Met QC Criteria

February 13, 2023

First Posted (Actual)

February 22, 2023

Study Record Updates

Last Update Posted (Actual)

June 11, 2026

Last Update Submitted That Met QC Criteria

June 9, 2026

Last Verified

June 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

CKJX839D12302

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Novartis is committed to sharing with qualified external researchers, access to patient-level data and supporting clinical documents from eligible studies. These requests are reviewed and approved by an independent review panel on the basis of scientific merit. All data provided is anonymized to respect the privacy of patients who have participated in the trial in line with applicable laws and regulations.

This trial data availability is according to the criteria and process described on www.clinicalstudydatarequest.com

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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Study Overview

Status

Conditions

Intervention / Treatment

Detailed Description

Study Type

Enrollment (Actual)

Phase

Contacts and Locations

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Secondary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Collaborators and Investigators

Sponsor

Investigators

Study record dates

Study Major Dates

Study Start (Actual)

Primary Completion (Estimated)

Study Completion (Estimated)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Actual)

Study Record Updates

Last Update Posted (Actual)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

IPD Plan Description

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product

Clinical Trials on Primary Prevention of Atherosclerotic Cardiovascular Disease

Clinical Trials on Inclisiran sodium 300 mg (equivalent to 284 mg inclisiran) in 1.5 mL

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