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En undersøgelse af Inclisiran til forebyggelse af kardiovaskulære hændelser hos højrisikopatienter med primær forebyggelse.

3. september 2026 opdateret af: Novartis Pharmaceuticals

En randomiseret, dobbeltblind, placebokontrolleret multicenterundersøgelse til evaluering af effekten af Inclisiran på forebyggelse af alvorlige uønskede kardiovaskulære hændelser hos højrisikopatienter med primær forebyggelse (VICTORION-1 PREVENT)

CKJX839D12302 er et pivotalt fase III studie designet til at teste hypotesen om, at behandling med inclisiran natrium 300 milligram (mg) subkutant (s.c.) administreret på dag 1, dag 90 og hver 6. måned derefter hos patienter med høj kardiovaskulær (CV) risiko uden en tidligere større aterosklerotisk kardiovaskulær sygdom (ASCVD)-hændelse vil signifikant reducere risikoen for 4-punkts-større kardiovaskulære hændelser (4P-MACE) defineret som en sammensætning af CV-død, ikke-dødelig myokardieinfarkt (MI), ikke-dødelig iskæmisk slagtilfælde og akut koronar revaskularisering sammenlignet med placebo.

Studieoversigt

Status

Aktiv, ikke rekrutterende

Betingelser

Primær forebyggelse af aterosklerotisk kardiovaskulær sygdom

Intervention / Behandling

Detaljeret beskrivelse

Formålet med denne undersøgelse er at evaluere inclisiran natrium 300 mg s.c. (svarende til 284 mg inclisiran) sammenlignet med placebo om at reducere risikoen for 4P-MACE hos voksne patienter med høj risiko for deres første alvorlige kardiovaskulære hændelse.

Randomiserede deltagere vil modtage undersøgelsesmedicin (inclisiran eller placebo), indgivet s.c. på dag 1, dag 90 og derefter hver 6. måned. Dette er en begivenhedsdrevet undersøgelse. Derfor vil undersøgelsen fortsætte, indtil det nødvendige antal kliniske hændelser er opstået på tværs af begge behandlingsarme, og alle deltagere har minimum 3 års opfølgning i den dobbeltblindede behandlingsperiode.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

14012

Fase

Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Argentina
- - Buenos Aires, Argentina, C1428DCO
    - Novartis Investigative Site
  - Buenos Aires, Argentina, W3400ABH
    - Novartis Investigative Site
  - Buenos Aires, Argentina, C1114AAP
    - Novartis Investigative Site
  - Caba, Argentina, C1015ABO
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  - Caba, Argentina, C1427CCL
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  - Capital Federal, Argentina, C1023AAB
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  - Corrientes, Argentina, 3400
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  - Córdoba, Argentina, X5000JHQ
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  - Córdoba, Argentina, X5000JHA
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  - Córdoba, Argentina, X5002HWE
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  - San Luis, Argentina, D5702JRS
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  - Santa Fe, Argentina, S3000EOZ
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- Buenos Aires
  - CABA, Buenos Aires, Argentina, C1221ADC
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  - CABA, Buenos Aires, Argentina, C1405BCH
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  - CABA, Buenos Aires, Argentina, 1425
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  - CABA, Buenos Aires, Argentina, C1406BOA
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  - CABA, Buenos Aires, Argentina, C1414AIF
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  - CABA, Buenos Aires, Argentina, C1425AGC
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  - CABA, Buenos Aires, Argentina, C1426ABP
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  - CABA, Buenos Aires, Argentina, C1280AEB
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  - CABA, Buenos Aires, Argentina, C1407FWE
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  - Caba, Buenos Aires, Argentina, C1119ACN
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  - Lanus, Buenos Aires, Argentina, B8000XAV
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  - Mar del Plata, Buenos Aires, Argentina, B7600ENA
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  - Ramos Mejía, Buenos Aires, Argentina, B1704ETD
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  - San Martín, Buenos Aires, Argentina, B1650CSQ
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- Córdoba Province
  - Córdoba, Córdoba Province, Argentina, 5200
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  - Córdoba, Córdoba Province, Argentina, X5000
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  - Córdoba, Córdoba Province, Argentina, X5003DCE
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  - Córdoba, Córdoba Province, Argentina, X5003DCP
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  - Córdoba, Córdoba Province, Argentina, X5016KEH
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- Entre Ríos Province
  - Concepcion Uruguay, Entre Ríos Province, Argentina, 3260
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  - Paraná, Entre Ríos Province, Argentina, 3100
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- Formosa Province
  - Formosa, Formosa Province, Argentina, P3600MPD
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- Mendoza Province
  - Mendoza, Mendoza Province, Argentina, 5500
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- Salta Province
  - Salta, Salta Province, Argentina, A4406BPF
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- San Miguel de Tucuman
  - San Miguel de Tucumán, San Miguel de Tucuman, Argentina, T4000ICL
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- Santa Fe Province
  - Grandero Baigorria, Santa Fe Province, Argentina, S2152
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  - Rosario, Santa Fe Province, Argentina, S2000DSV
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  - Rosario, Santa Fe Province, Argentina, S2000DBS
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  - Rosario, Santa Fe Province, Argentina, S2000CVD
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  - Santa Fe, Santa Fe Province, Argentina, S3000FWO
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- Tucumán Province
  - San Miguel, Tucumán Province, Argentina, 4400
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  - San Miguel Tucuman, Tucumán Province, Argentina, T4000IFL
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Australien
- Australian Capital Territory
  - Garran, Australian Capital Territory, Australien, 2605
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- New South Wales
  - Camperdown, New South Wales, Australien, 2050
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  - Concord, New South Wales, Australien, 2139
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- Queensland
  - Auchenflower, Queensland, Australien, 4066
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  - Sippy Downs, Queensland, Australien, 4556
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  - Woolloongabba, Queensland, Australien, 4102
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- South Australia
  - Adelaide, South Australia, Australien, 5000
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  - Leabrook, South Australia, Australien, 5068
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- Tasmania
  - Hobart, Tasmania, Australien, 7000
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- Victoria
  - Clayton, Victoria, Australien, 3168
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  - Heidelberg, Victoria, Australien, 3084
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  - Malvern East, Victoria, Australien, 3145
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- Western Australia
  - Joondalup, Western Australia, Australien, 6027
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Belgien
- - Dendermonde, Belgien, 9200
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  - Mechelen, Belgien, 2800
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- Limburg
  - Genk, Limburg, Belgien, 3600
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- Oost Vlaanderen
  - Aalst, Oost Vlaanderen, Belgien, 9300
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Brasilien
- - Campinas, Brasilien, 13092-133
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  - Rio de Janeiro, Brasilien, 20241-180
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  - Rio de Janeiro, Brasilien, 22270-060
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- Alagoas
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- Espírito Santo
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- Estado de Bahia
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- Federal District
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- Paraná
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- Rio Grande do Sul
  - Canoas, Rio Grande do Sul, Brasilien, 92425-900
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  - Pelotas, Rio Grande do Sul, Brasilien, 96015-290
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  - Porto Alegre, Rio Grande do Sul, Brasilien, 90560-032
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  - Porto Alegre, Rio Grande do Sul, Brasilien, 90160-093
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- Santa Catarina
  - Blumenau, Santa Catarina, Brasilien, 89020-430
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- Sergipe
  - Aracaju, Sergipe, Brasilien, 49055-530
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- São Paulo
  - Campinas, São Paulo, Brasilien, 13060-080
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  - Ribeirão Preto, São Paulo, Brasilien, 14048-900
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  - Santo André, São Paulo, Brasilien, 09030-010
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  - Sao Jose Rio Preto, São Paulo, Brasilien, 15090-000
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  - São José dos Campos, São Paulo, Brasilien, 12243-280
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  - São Paulo, São Paulo, Brasilien, 01323001
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  - São Paulo, São Paulo, Brasilien, 04012-909
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  - São Paulo, São Paulo, Brasilien, 04266-010
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  - São Paulo, São Paulo, Brasilien, 01323-000
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  - Votuporanga, São Paulo, Brasilien, 15500-269
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Bulgarien
- - Blagoevgrad, Bulgarien, 2700
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  - Burgas, Bulgarien, 8001
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  - Gabrovo, Bulgarien, 5300
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  - Kyustendil, Bulgarien, 2500
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  - Pleven, Bulgarien, 5800
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  - Plovdiv, Bulgarien, 4002
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  - Sandanski, Bulgarien, 2800
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  - Sofia, Bulgarien, 1233
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  - Sofia, Bulgarien, 1606
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  - Sofia, Bulgarien, 1750
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  - Sofia, Bulgarien, 1510
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  - Sofia, Bulgarien, 1504
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  - Stara Zagora, Bulgarien, 6000
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  - Varna, Bulgarien, 9010
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  - Veliko Tarnovo, Bulgarien, 5000
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- Bulgaria
  - Sofia, Bulgaria, Bulgarien, 1202
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- Burgas
  - Burgas, Burgas, Bulgarien, 8000
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Canada
- Alberta
  - Calgary, Alberta, Canada, T2H 2G4
    - Novartis Investigative Site
  - Edmonton, Alberta, Canada, T6K 4C1
    - Novartis Investigative Site
  - Red Deer, Alberta, Canada, T4P 1K4
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- British Columbia
  - Kelowna, British Columbia, Canada, V1Y 3J8
    - Novartis Investigative Site
  - Vancouver, British Columbia, Canada, V6Z 1Y6
    - Novartis Investigative Site
- New Brunswick
  - Moncton, New Brunswick, Canada, E1G 1A7
    - Novartis Investigative Site
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 2Y9
    - Novartis Investigative Site
  - New Minas, Nova Scotia, Canada, B4N 3R7
    - Novartis Investigative Site
- Ontario
  - Barrie, Ontario, Canada, L4N 7L3
    - Novartis Investigative Site
  - Brampton, Ontario, Canada, L6S 0C6
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  - Etobicoke, Ontario, Canada, M9R 4E1
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  - Guelph, Ontario, Canada, N1H 1B1
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  - Hamilton, Ontario, Canada, L8L 5G4
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  - London, Ontario, Canada, N6A 5W9
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  - Napean, Ontario, Canada, K2J 0V2
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  - Newmarket, Ontario, Canada, L3Y 2P6
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  - North York, Ontario, Canada, M6B 3H7
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  - Oshawa, Ontario, Canada, L1J 2K9
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  - Scarborough Village, Ontario, Canada, M1B 5N1
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  - Thornhill, Ontario, Canada, L4J 8L7
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  - Toronto, Ontario, Canada, M4G 3E8
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- Quebec
  - Lévis, Quebec, Canada, G6W 5M6
    - Novartis Investigative Site
  - Mirabel, Quebec, Canada, J7J 2K8
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  - Montreal, Quebec, Canada, H4A 3J1
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  - Québec, Quebec, Canada, G2J 0C4
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  - Québec, Quebec, Canada, G1V 4G5
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  - Terrebonne, Quebec, Canada, J6X 4P7
    - Novartis Investigative Site
  - Trois-Rivières, Quebec, Canada, G9A 4P3
    - Novartis Investigative Site
  - Victoriaville, Quebec, Canada, G6P 3Z8
    - Novartis Investigative Site
Colombia
- - Bogotá, Colombia, 110221
    - Novartis Investigative Site
  - Cali, Colombia, 760004
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  - Manizales, Colombia, 170008
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  - Medellín, Colombia, 050012
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  - Medellín, Colombia, 050037
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  - Medellín, Colombia, 050034
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  - San Gil, Colombia, 684031
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- Antioquia
  - Medellín, Antioquia, Colombia, 050021
    - Novartis Investigative Site
  - Medellín, Antioquia, Colombia, 050010
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- Atlántico
  - Barranquilla, Atlántico, Colombia, 080002
    - Novartis Investigative Site
  - Barranquilla, Atlántico, Colombia, 080012
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  - Barranquilla, Atlántico, Colombia, 080020
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- Colombia
  - Barranquilla, Colombia, Colombia, 080020
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- Cundinamarca
  - Chía, Cundinamarca, Colombia, 250001
    - Novartis Investigative Site
- Santander Department
  - Bucaramanga, Santander Department, Colombia, 681017
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  - Floridablanca, Santander Department, Colombia, 691001
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- Tolima Department
  - Ibague, Tolima Department, Colombia, 730006
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- Valle del Cauca Department
  - Cali, Valle del Cauca Department, Colombia, 760001
    - Novartis Investigative Site
Danmark
- - Aarhus N, Danmark, 8200
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  - Copenhagen S, Danmark, 2300
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  - Esbjerg, Danmark, 6700
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  - Gandrup, Danmark, 9362
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  - Herlev, Danmark, 2730
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  - Herning, Danmark, 7400
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  - Kobenhavn N V, Danmark, 2400
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  - Roskilde, Danmark, 4000
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  - Svendborg, Danmark, 5700
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  - Vejle, Danmark, 7100
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Det Forenede Kongerige
- - Belfast, Det Forenede Kongerige, BT16 1RH
    - Novartis Investigative Site
  - Belfast, Det Forenede Kongerige, BT2 8BG
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  - Birmingham, Det Forenede Kongerige, B21 9RY
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  - Blackpool, Det Forenede Kongerige, FY3 8NR
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  - Bristol, Det Forenede Kongerige, BS2 8HW
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  - Cardiff, Det Forenede Kongerige, CF64 2XX
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  - Chesterfield, Det Forenede Kongerige, S40 4AA
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  - Denbighshire, Det Forenede Kongerige, LL18 1DA
    - Novartis Investigative Site
  - Edinburgh, Det Forenede Kongerige, EH16 4SA
    - Novartis Investigative Site
  - Glasgow, Det Forenede Kongerige, G20 7BE
    - Novartis Investigative Site
  - Kettering, Det Forenede Kongerige, NN16 8UZ
    - Novartis Investigative Site
  - Lancashire, Det Forenede Kongerige, FY4 3AD
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  - London, Det Forenede Kongerige, W12 0HS
    - Novartis Investigative Site
  - Londonderry, Det Forenede Kongerige, BT47 6SB
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  - Middlesex, Det Forenede Kongerige, TW7 6AF
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  - Norwich, Det Forenede Kongerige, NR4 7UY
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  - Plymouth, Det Forenede Kongerige, PL5 3JB
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  - Plympton, Det Forenede Kongerige, PL7 2QP
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  - Rhyl, Det Forenede Kongerige, LL18 5UJ
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  - Salford, Det Forenede Kongerige, M6 8HD
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  - Scunthorpe, Det Forenede Kongerige, DN15 7BH
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  - Sheffield, Det Forenede Kongerige, S5 7AU
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  - Tyne and Wear, Det Forenede Kongerige, NE29 8NH
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  - Wiltshire, Det Forenede Kongerige, SN15 2SB
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  - Wirrel, Det Forenede Kongerige, CH62 6EE
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  - Wrexham, Det Forenede Kongerige, LL13 7TD
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- Beds
  - Luton, Beds, Det Forenede Kongerige, LU4 0DZ
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- Buckinghamshire
  - High Wycombe, Buckinghamshire, Det Forenede Kongerige, HP11 2TT
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- Cambridgeshire
  - Peterborough, Cambridgeshire, Det Forenede Kongerige, PE3 9GZ
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- Cornwall
  - Connor Downs, Cornwall, Det Forenede Kongerige, TR27 5DT
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  - Fowey, Cornwall, Det Forenede Kongerige, PL23 1DT
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  - Liskeard, Cornwall, Det Forenede Kongerige, PL14 3XA
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  - Newquay, Cornwall, Det Forenede Kongerige, TR7 1RU
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- Devon
  - Exeter, Devon, Det Forenede Kongerige, EX2 5DW
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- Dorset
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- GBR
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- Middlesex
  - Harrow, Middlesex, Det Forenede Kongerige, HA1 3UJ
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- Northamptonshire
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- Nothern Ireland
  - Portadown, Nothern Ireland, Det Forenede Kongerige, BT63 5QQ
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- Peterborough
  - Wansford, Peterborough, Det Forenede Kongerige, PE8 6PL
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- South Gloucestershire
  - Bristol, South Gloucestershire, Det Forenede Kongerige, BS37 4AX
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- Stockton on Tees
  - Hardwick, Stockton on Tees, Det Forenede Kongerige, TS19 8PE
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- Suffolk
  - Bury St Edmunds, Suffolk, Det Forenede Kongerige, IP33 2QZ
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- Wales
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Estland
- - Pärnu, Estland, 80018
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  - Tallinn, Estland, 13419
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  - Tallinn, Estland, 10138
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  - Tallinn, Estland, 13619
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  - Tallinn, Estland, 10128
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  - Tartu, Estland, 50708
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- Estonia
  - Tartu, Estonia, Estland, 50406
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Filippinerne
- - Manila, Filippinerne, 1000
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  - Quezon, Filippinerne, 1102
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  - San Juan City, Filippinerne, 1502
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- Iloilo
  - Iloilo City, Iloilo, Filippinerne, 5000
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- National Capital Region
  - Manila, National Capital Region, Filippinerne, 1000
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Forenede Stater
- Alabama
  - Birmingham, Alabama, Forenede Stater, 35209
    - Central Alabama Research
  - Birmingham, Alabama, Forenede Stater, 35211
    - UAB St Vincents
  - Fairhope, Alabama, Forenede Stater, 36532
    - Eastern Shore Research Institute
  - Foley, Alabama, Forenede Stater, 36535
    - G and L Research LLC
  - Huntsville, Alabama, Forenede Stater, 35801
    - Longwood Research
  - Mobile, Alabama, Forenede Stater, 36608
    - CB Flock Corporation
  - Saraland, Alabama, Forenede Stater, 36571
    - The Center for Clinical Trials
- Arizona
  - Glendale, Arizona, Forenede Stater, 85308
    - Lenzmeier Family Practice
  - Glendale, Arizona, Forenede Stater, 85306
    - Synexus
  - Sun City West, Arizona, Forenede Stater, 85375
    - Clinical Research Inst of Arizona
  - Tempe, Arizona, Forenede Stater, 85283
    - Clinical Research Advantage Fiel Family and Sports Med, PC
  - Tucson, Arizona, Forenede Stater, 85741
    - Synexus Clinical Research US Inc
- California
  - Beverly Hills, California, Forenede Stater, 90211
    - National Heart Institute
  - Beverly Hills, California, Forenede Stater, 90210
    - Cardiovascular Res Found
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    - Alliance Clinical
  - Chino, California, Forenede Stater, 91710
    - Inland Psychiatric Medical Group
  - Covina, California, Forenede Stater, 91723
    - Valley Clinical Trials Inc
  - Los Angeles, California, Forenede Stater, 90033
    - Keck Medical Center USC
  - Los Angeles, California, Forenede Stater, 90059
    - Charles R Drew University of Medicine and Science
  - Newhall, California, Forenede Stater, 91321
    - C for Endo Diabetes and MD
  - Northridge, California, Forenede Stater, 91325
    - Valley Clinical Trials
  - Northridge, California, Forenede Stater, 91324
    - California Medical Research Associates Inc
  - Palo Alto, California, Forenede Stater, 94304
    - Stanford University Medical Center
  - Sacramento, California, Forenede Stater, 95841
    - Cordova Clinical Research
  - Sacramento, California, Forenede Stater, 95821-2134
    - Clinical Trials Research Sacramento
  - San Diego, California, Forenede Stater, 92123
    - San Diego Cardiac Center
  - San Diego, California, Forenede Stater, 92120
    - Acclaim Clinical Research
  - San Diego, California, Forenede Stater, 92103
    - University of California San Diego
  - San Diego, California, Forenede Stater, 92108
    - Kaiser Permanente San Diego
  - Spring Valley, California, Forenede Stater, 91978
    - Encompass Clinical Research
  - Torrance, California, Forenede Stater, 90502
    - Harbor UCLA Medical Center
  - Ventura, California, Forenede Stater, 93003
    - Cardiology Associates Medical Group
  - Vista, California, Forenede Stater, 92081
    - Blue Coast Research Center LLC
  - West Hills, California, Forenede Stater, 91307
    - Interv Cardiology Med Grp
- Colorado
  - Littleton, Colorado, Forenede Stater, 80120
    - South Denver Cardiology Associates PC
- Connecticut
  - Stamford, Connecticut, Forenede Stater, 06905
    - Cardiology Ass of Fairfield County
  - Waterbury, Connecticut, Forenede Stater, 06708
    - Chase Medical Research LLC
- Florida
  - Boca Raton, Florida, Forenede Stater, 33434
    - Excel Medical Clinical Trials LLC
  - Bradenton, Florida, Forenede Stater, 34209
    - Nova Clinical Research LLC
  - Clearwater, Florida, Forenede Stater, 33761
    - Tampa Bay Medical Research
  - Clearwater, Florida, Forenede Stater, 33756
    - Clearwater Cardiovascular and Interventional Consultants
  - Clearwater, Florida, Forenede Stater, 33756
    - Bay Care Medical Group
  - Daytona Beach, Florida, Forenede Stater, 32117
    - Cardiology Research Associates
  - DeLand, Florida, Forenede Stater, 32720
    - Hillcrest Medical Research
  - Delray Beach, Florida, Forenede Stater, 33445
    - Personal Physicians Care
  - Fleming Island, Florida, Forenede Stater, 32003
    - Fleming Island Ctr Clinical Res.
  - Fort Lauderdale, Florida, Forenede Stater, 33308
    - Proactive Clinical Research
  - Hialeah, Florida, Forenede Stater, 33010
    - Qway Research
  - Hialeah, Florida, Forenede Stater, 33013
    - Sister Life Research Inc
  - Hollywood, Florida, Forenede Stater, 33021
    - Center for Diabetes and Endocrine Care
  - Hollywood, Florida, Forenede Stater, 33021
    - Zenith Clinical Research
  - Hollywood, Florida, Forenede Stater, 33024
    - Encore Medical Research
  - Hollywood, Florida, Forenede Stater, 33021
    - South Florida Rsrch Solutions LLC
  - Jacksonville, Florida, Forenede Stater, 32216
    - East Coast Institute for Research
  - Jacksonville, Florida, Forenede Stater, 32209
    - UF Health Science Center
  - Miami, Florida, Forenede Stater, 33126
    - Finlay Medical Research
  - Miami, Florida, Forenede Stater, 33133
    - Infinite Clinical Research
  - Miami, Florida, Forenede Stater, 33125
    - Columbus Clinical Services LLC
  - Miami, Florida, Forenede Stater, 33156
    - International Research Associates LLC
  - Miami, Florida, Forenede Stater, 33186
    - A&A Research Group Inc
  - Miami, Florida, Forenede Stater, 33135
    - Springs Medical And Research
  - Miami, Florida, Forenede Stater, 33144
    - L and C Professional Medical Institute
  - Miami, Florida, Forenede Stater, 33155
    - Regenerate Clinical Trial
  - Miami Gardens, Florida, Forenede Stater, 33014
    - Meridian International Research
  - Miami Lakes, Florida, Forenede Stater, 33014
    - Inpatient Research Clinical LLC
  - Miami Lakes, Florida, Forenede Stater, 33014
    - RM Medical Research Inc
  - Miami Lakes, Florida, Forenede Stater, 33016
    - Indago Research and Health Ctr Inc
  - Miramar, Florida, Forenede Stater, 33027
    - FXM Clin Res Miramar LLC
  - Orlando, Florida, Forenede Stater, 32803
    - Advent Health Orlando
  - Palm Springs, Florida, Forenede Stater, 33406
    - CTMD Research
  - Pembroke Pines, Florida, Forenede Stater, 33029
    - DBC Research USA
  - Plant City, Florida, Forenede Stater, 33563
    - Fam Medical Specialists Of Fl Plc
  - Ponte Vedra, Florida, Forenede Stater, 32801
    - St Johns Center
  - Port Charlotte, Florida, Forenede Stater, 33952
    - Peace River Cardiovascular Center
  - Saint Augustine, Florida, Forenede Stater, 32086
    - East Coast Inst for Research LLC
  - Sarasota, Florida, Forenede Stater, 34239
    - Cardiovascular Center of Sarasota
  - St. Petersburg, Florida, Forenede Stater, 33713
    - Advanced Medical Research Center
  - Tampa, Florida, Forenede Stater, 33612
    - James A Haley Veterans Hospital
  - Tampa, Florida, Forenede Stater, 33705
    - BayCare Health System
  - Wellington, Florida, Forenede Stater, 33449
    - Cardiology Partners Clinical Research Institute
  - Winter Park, Florida, Forenede Stater, 32789
    - Flourish Research
- Georgia
  - Canton, Georgia, Forenede Stater, 30114
    - East Coast Research
  - Fayetteville, Georgia, Forenede Stater, 30214
    - Javara Research
  - Macon, Georgia, Forenede Stater, 31210
    - The Jones Center For Diabetes And Endocrine Wellness
  - Tucker, Georgia, Forenede Stater, 30084
    - Atlanta Heart Specialists LLC
- Hawaii
  - Honolulu, Hawaii, Forenede Stater, 96814
    - East West Research Institute
- Idaho
  - Sandpoint, Idaho, Forenede Stater, 83864
    - Kootenai Heart Clinic-Sandpoint
- Illinois
  - Arlington Heights, Illinois, Forenede Stater, 60005
    - Endeavor Health Clinical Op- NCH
  - Chicago, Illinois, Forenede Stater, 60612
    - University of Illinois at Chicago
  - Chicago, Illinois, Forenede Stater, 60607
    - Chicago Clinical Research Inst
  - Peoria, Illinois, Forenede Stater, 61602
    - Cardiovascular Services
- Indiana
  - Elkhart, Indiana, Forenede Stater, 46514
    - Beacon Health System
  - Valparaiso, Indiana, Forenede Stater, 46383
    - Buynak Clinical Research PC
- Iowa
  - Council Bluffs, Iowa, Forenede Stater, 51501
    - West Broadway Clinic
- Kansas
  - Hutchinson, Kansas, Forenede Stater, 67502
    - Hutchinson Clinic
  - Topeka, Kansas, Forenede Stater, 66606
    - Cotton O Neil Clinical Res Center
  - Wichita, Kansas, Forenede Stater, 67214
    - Kansas Nephrology Research Institute LLC
- Kentucky
  - Bowling Green, Kentucky, Forenede Stater, 42101
    - Graves Gilbert Clinic
  - Lexington, Kentucky, Forenede Stater, 40503
    - The Research Group
  - Owensboro, Kentucky, Forenede Stater, 42303
    - Research Integrity LLC
- Louisiana
  - Covington, Louisiana, Forenede Stater, 70433
    - Cardiovascular Associates Research
  - Covington, Louisiana, Forenede Stater, 70433
    - Louisiana Heart Center Research
  - Crowley, Louisiana, Forenede Stater, 70526
    - Avant Research Associates LLC
  - Mandeville, Louisiana, Forenede Stater, 70448
    - North Shore Heart and Vascular
  - Marrero, Louisiana, Forenede Stater, 70072
    - Bethesda Medical Clinic
  - Metairie, Louisiana, Forenede Stater, 70006
    - Omega Clinical Research
  - Metairie, Louisiana, Forenede Stater, 70006
    - NOLA Care Clinical Research
  - Opelousas, Louisiana, Forenede Stater, 70570
    - CV Ins of the South
  - Shreveport, Louisiana, Forenede Stater, 71103
    - Cardiovascular Solutions LLC
  - Slidell, Louisiana, Forenede Stater, 70458
    - Louisiana Heart Center Research
  - West Monroe, Louisiana, Forenede Stater, 71291
    - Monroe Research LLC
  - Zachary, Louisiana, Forenede Stater, 70791
    - Southern Clinical Research
- Maine
  - Bangor, Maine, Forenede Stater, 04401
    - Northeast Cardiology Associates
- Maryland
  - Baltimore, Maryland, Forenede Stater, 21229
    - Ascension Saint Agnes Heart Care
  - Beltsville, Maryland, Forenede Stater, 20705
    - Metropolitan Cardiovascular Consultants LLC
  - Columbia, Maryland, Forenede Stater, 21044
    - Johns Hopkins University
  - Ft. Washington, Maryland, Forenede Stater, 20744
    - Anderson Medical Research
  - Lanham, Maryland, Forenede Stater, 20706
    - Capitol Cardiology Associates
- Massachusetts
  - Boston, Massachusetts, Forenede Stater, 02114-2696
    - MGH
  - Worcester, Massachusetts, Forenede Stater, 01655
    - UMass Memorial Medical Center
- Michigan
  - Detroit, Michigan, Forenede Stater, 48202
    - Henry Ford Hospital
  - Flint, Michigan, Forenede Stater, 48504
    - AA Medical Research Center
  - Midland, Michigan, Forenede Stater, 48670
    - MyMichigan Medical Center Midland
  - Saginaw, Michigan, Forenede Stater, 48601
    - Central Michigan University
  - Troy, Michigan, Forenede Stater, 48098
    - Troy Internal Medicine Research
  - Ypsilanti, Michigan, Forenede Stater, 48197
    - Trinity Health Michigan Heart
- Minnesota
  - Duluth, Minnesota, Forenede Stater, 55805
    - Essentia Health
  - Minneapolis, Minnesota, Forenede Stater, 55407-3799
    - Abbott Northwestern Hospital
  - Richfield, Minnesota, Forenede Stater, 55432
    - Synexus Clinical Research US Inc
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - Park Nicollet Institute
  - Saint Paul, Minnesota, Forenede Stater, 55103
    - Fairview Health Services
- Mississippi
  - Jackson, Mississippi, Forenede Stater, 39216
    - Jackson Heart Clinic
  - Jackson, Mississippi, Forenede Stater, 39216
    - VAMC Research-G V Sonny Montgomery Clinic
  - Jackson, Mississippi, Forenede Stater, 39202
    - Elite Clinical Research LLC
  - Port Gibson, Mississippi, Forenede Stater, 39150
    - David M Headley Clinic
  - Tupelo, Mississippi, Forenede Stater, 38801
    - Cardiology Associates of North MS
- Missouri
  - City of Saint Peters, Missouri, Forenede Stater, 63303
    - StudyMetrix Research
  - Kansas City, Missouri, Forenede Stater, 64128
    - Kansas City VA Medical Center
  - St Louis, Missouri, Forenede Stater, 63125-4181
    - St Louis V A Medical Center
  - St Louis, Missouri, Forenede Stater, 63110
    - Barnes Jewish Hosp-Washington Univ
  - St Louis, Missouri, Forenede Stater, 63136
    - St Louis Heart and Vascular
  - St Louis, Missouri, Forenede Stater, 63141
    - Synexus Clinical Research US Inc
- Montana
  - Butte, Montana, Forenede Stater, 59701
    - Mercury Street Medical
- Nebraska
  - Lincoln, Nebraska, Forenede Stater, 68516
    - Lincoln Internal Medicine Associates
  - Lincoln, Nebraska, Forenede Stater, 68510
    - Nebraska Heart Institute
  - Omaha, Nebraska, Forenede Stater, 68130
    - CCT Research
  - Omaha, Nebraska, Forenede Stater, 68198
    - University of Nebraska Med Center
- Nevada
  - Henderson, Nevada, Forenede Stater, 89074
    - Las Vegas Endocrinology
  - Las Vegas, Nevada, Forenede Stater, 89119
    - AB Clinical Trials
  - Las Vegas, Nevada, Forenede Stater, 89121
    - Clinical Research of South Nevada
- New Jersey
  - Bridgewater, New Jersey, Forenede Stater, 08807
    - Advanced Heart Care
  - Elmer, New Jersey, Forenede Stater, 08318
    - Cardiovas Assoc of Delaware Valley
  - Linden, New Jersey, Forenede Stater, 07036
    - New Jersey Heart
- New York
  - Albany, New York, Forenede Stater, 12211
    - Capital Cardiology Associates
  - Albany, New York, Forenede Stater, 12206
    - Albany Medical College
  - Flushing, New York, Forenede Stater, 11355
    - New York Presbyterian Queens
  - New Windsor, New York, Forenede Stater, 12553
    - Mid Hudson Medical Research PLLC
  - Poughkeepsie, New York, Forenede Stater, 12601
    - Hudson Valley Urology
  - Rochester, New York, Forenede Stater, 14609
    - Rochester Clinical Research
  - The Bronx, New York, Forenede Stater, 10468
    - Clinical Research Advantage
  - Valhalla, New York, Forenede Stater, 10595
    - Westchester Medical Center
  - Westfield, New York, Forenede Stater, 14787
    - Great Lakes Medical Research
- North Carolina
  - Cary, North Carolina, Forenede Stater, 27511
    - Cary Research Group
  - Greensboro, North Carolina, Forenede Stater, 27401
    - Moses Cone Hospital
  - Greensboro, North Carolina, Forenede Stater, 27405
    - Medication Management LLC
  - Mount Airy, North Carolina, Forenede Stater, 27030
    - IMA Research
  - Raleigh, North Carolina, Forenede Stater, 27609
    - Multispecialty Research Ass Of NC
  - Statesville, North Carolina, Forenede Stater, 28625
    - Accellacare
  - Wilmington, North Carolina, Forenede Stater, 28401
    - Adv Imaging Prev and Clin Research
  - Winston-Salem, North Carolina, Forenede Stater, 27157
    - Wake Forest University Baptist Medical Center
- North Dakota
  - Fargo, North Dakota, Forenede Stater, 58103
    - Lillestol Research LLC
  - Grand Forks, North Dakota, Forenede Stater, 58201
    - Altru Health Research Dept.
- Ohio
  - Canton, Ohio, Forenede Stater, 44710
    - Aultman Hospital
  - Cincinnati, Ohio, Forenede Stater, 45236
    - Synexus Clinical Research US Inc
  - Columbus, Ohio, Forenede Stater, 43212
    - Synexus Clinical Research
  - Dayton, Ohio, Forenede Stater, 45429
    - PriMED Clinical Research
  - Dayton, Ohio, Forenede Stater, 45439
    - Providence Medical Group
  - Lima, Ohio, Forenede Stater, 45801
    - Nexgen Research
  - Marion, Ohio, Forenede Stater, 43302
    - Rama Research LLC
  - Springfield, Ohio, Forenede Stater, 45504
    - Heart House Research Foundation
- Oklahoma
  - Oklahoma City, Oklahoma, Forenede Stater, 73112
    - Lynn Health Science Institute
  - Oklahoma City, Oklahoma, Forenede Stater, 73135
    - South Oklahoma Heart Research LLC
- Pennsylvania
  - Horsham, Pennsylvania, Forenede Stater, 19044
    - CCT Hatboro Medical Associates
  - Newport, Pennsylvania, Forenede Stater, 17074
    - Capital Area Research LLC
  - Pittsburgh, Pennsylvania, Forenede Stater, 15212
    - Allegheny General Hospital
  - Smithfield, Pennsylvania, Forenede Stater, 15478
    - Frontier Clinical Research LLC
- Rhode Island
  - Warwick, Rhode Island, Forenede Stater, 02886
    - Care Access
- South Carolina
  - Columbia, South Carolina, Forenede Stater, 29209
    - Columbia VA Health Care System
  - Greenville, South Carolina, Forenede Stater, 29607
    - Bon Secours Medical Group
  - Greer, South Carolina, Forenede Stater, 29651
    - TRIBE Clinical Research
  - Ladson, South Carolina, Forenede Stater, 29465
    - Trident Cardiology
  - Little River, South Carolina, Forenede Stater, 29566
    - Main Street Physicians Care
- South Dakota
  - Rapid City, South Dakota, Forenede Stater, 57701
    - Monument Health Clinical Research
  - Rapid City, South Dakota, Forenede Stater, 57701
    - Care Access Research
- Tennessee
  - Greenville, Tennessee, Forenede Stater, 37745
    - Wellmont CVA Heart Institute
  - Jackson, Tennessee, Forenede Stater, 38301
    - Apex Cardiology Research Associates of Jackson
  - Kingsport, Tennessee, Forenede Stater, 37660
    - Holston Medical Group
  - Knoxville, Tennessee, Forenede Stater, 37909
    - New Phase Research and Development
  - Knoxville, Tennessee, Forenede Stater, 37938
    - Accellacare
  - Powell, Tennessee, Forenede Stater, 37849
    - Cardiovascular Res of Knoxville LLC
  - Tullahoma, Tennessee, Forenede Stater, 37388
    - Tennessee Center for Clinical Trials
- Texas
  - Amarillo, Texas, Forenede Stater, 79106
    - Pharma Tex Research
  - Amarillo, Texas, Forenede Stater, 79124
    - Amarillo Heart Clin Rsh Inst
  - Bedford, Texas, Forenede Stater, 76021
    - North Hills Medical Research Inc
  - Cypress, Texas, Forenede Stater, 77429
    - Clinical Research Solution
  - Dallas, Texas, Forenede Stater, 75216
    - VA North Texas Health Care System
  - Dallas, Texas, Forenede Stater, 75230
    - Zenos Clinical Research
  - Dallas, Texas, Forenede Stater, 75235
    - SW Family Medicine Associates
  - El Paso, Texas, Forenede Stater, 79905
    - David Turbay MD PLLC
  - Fort Worth, Texas, Forenede Stater, 76107
    - Texas Health Physicians Group
  - Houston, Texas, Forenede Stater, 77024
    - Primecare Medical Group
  - Houston, Texas, Forenede Stater, 77002
    - East Texas Cardiology PA
  - Houston, Texas, Forenede Stater, 77070
    - Northwest Houston Cardiology PA
  - Houston, Texas, Forenede Stater, 77079
    - MedCare Pharma LLC
  - Houston, Texas, Forenede Stater, 77084
    - Dallas Heart and Vascular Consultants PA
  - Kingwood, Texas, Forenede Stater, 77339
    - Texas Cardiology Assocs Of Houston
  - Lewisville, Texas, Forenede Stater, 75057
    - Epic Clinical Research
  - Livingston, Texas, Forenede Stater, 77351
    - East Texas Research Associates Inc.
  - McAllen, Texas, Forenede Stater, 78504
    - Doctors Hospital at Renaissance
  - Red Oak, Texas, Forenede Stater, 75154
    - Epic Medical Research
  - San Antonio, Texas, Forenede Stater, 78233
    - Northeast Clinical Research of San Antonio LLC
  - Shavano Park, Texas, Forenede Stater, 78231
    - Consano Clinical Research LLC
  - Stephenville, Texas, Forenede Stater, 76401
    - Javara Research
  - Sugarland, Texas, Forenede Stater, 77478
    - NRG Wellness Center
  - Tomball, Texas, Forenede Stater, 77375
    - Northwest Houston Clinical Research PLLC
  - Weslaco, Texas, Forenede Stater, 78596
    - Comprehensive Center
- Utah
  - Murray, Utah, Forenede Stater, 84107
    - Intermountain Medical Center
  - Sandy City, Utah, Forenede Stater, 84093
    - Diabetes And Endocrine Specialists
- Virginia
  - Burke, Virginia, Forenede Stater, 22015
    - Burke Internal Medicine and Research
  - Falls Church, Virginia, Forenede Stater, 22042
    - Virginia Heart
  - Hopewell, Virginia, Forenede Stater, 23860
    - Heart Care Associates P C
  - Manassas, Virginia, Forenede Stater, 20110
    - Manassas Clinical Research Center
  - Manassas, Virginia, Forenede Stater, 20109
    - Carient Heart and Vascular
  - Richmond, Virginia, Forenede Stater, 23298-0111
    - Virginia Commonwealth University
  - Roanoke, Virginia, Forenede Stater, 24014
    - Roanoke Heart Institute
  - Suffolk, Virginia, Forenede Stater, 23435
    - Centricity Research Suffolk Fam Med
- Washington
  - Puyallup, Washington, Forenede Stater, 98372
    - MultiCare Ins Research Innovation
  - Tacoma, Washington, Forenede Stater, 98405
    - Universal Research Group LLC
  - Wenatchee, Washington, Forenede Stater, 98801
    - Confluence Health Hospital
- West Virginia
  - Morgantown, West Virginia, Forenede Stater, 26506
    - West Virginia University Hospital
- Wisconsin
  - Milwaukee, Wisconsin, Forenede Stater, 53215
    - Midwest Endocrinology Associates
  - Wausau, Wisconsin, Forenede Stater, 54401
    - Cardiovascular Research and Education Foundation Inc
Frankrig
- - Avignon, Frankrig, 84000
    - Novartis Investigative Site
  - Besançon, Frankrig, 25030
    - Novartis Investigative Site
  - Bobigny, Frankrig, 93009
    - Novartis Investigative Site
  - Bordeaux, Frankrig, 33075
    - Novartis Investigative Site
  - Béziers, Frankrig, 34525
    - Novartis Investigative Site
  - Caen, Frankrig, 14033
    - Novartis Investigative Site
  - Compiègne, Frankrig, 60321
    - Novartis Investigative Site
  - Dijon, Frankrig, 21000
    - Novartis Investigative Site
  - Marseille, Frankrig, 13005
    - Novartis Investigative Site
  - Montauban, Frankrig, 82017
    - Novartis Investigative Site
  - Montpellier, Frankrig, 34295
    - Novartis Investigative Site
  - Nantes, Frankrig, 44093
    - Novartis Investigative Site
  - Nice, Frankrig, 06202
    - Novartis Investigative Site
  - Orléans, Frankrig, 45100
    - Novartis Investigative Site
  - Paris, Frankrig, 75013
    - Novartis Investigative Site
  - Paris, Frankrig, 75015
    - Novartis Investigative Site
  - Paris, Frankrig, 75012
    - Novartis Investigative Site
  - Paris, Frankrig, 75018
    - Novartis Investigative Site
  - Poitiers, Frankrig, 86021
    - Novartis Investigative Site
  - Rouen, Frankrig, 76031
    - Novartis Investigative Site
  - Strasbourg, Frankrig, 67091
    - Novartis Investigative Site
  - Tourcoing, Frankrig, 59208
    - Novartis Investigative Site
  - Valenciennes, Frankrig, 59300
    - Novartis Investigative Site
  - Vandœuvre-lès-Nancy, Frankrig, 54511
    - Novartis Investigative Site
  - Villeneuve-d'Ascq, Frankrig, 59650
    - Novartis Investigative Site
Grækenland
- - Athens, Grækenland, 115 27
    - Novartis Investigative Site
  - Athens, Grækenland, 151 23
    - Novartis Investigative Site
  - Athens, Grækenland, 115 21
    - Novartis Investigative Site
  - Heraklion Crete., Grækenland, 715 00
    - Novartis Investigative Site
  - Ioannina, Grækenland, 455 00
    - Novartis Investigative Site
  - Thessaloniki, Grækenland, 570 01
    - Novartis Investigative Site
  - Thessaloniki, Grækenland, 546 42
    - Novartis Investigative Site
  - Thessaloniki, Grækenland, 564 03
    - Novartis Investigative Site
Holland
- - Ede, Holland, 6716 RP
    - Novartis Investigative Site
  - Eindhoven, Holland, 5623 EJ
    - Novartis Investigative Site
  - Enschede, Holland, 7512KZ
    - Novartis Investigative Site
  - Gouda, Holland, 2803 HH
    - Novartis Investigative Site
  - Hardenberg, Holland, 7770 SE
    - Novartis Investigative Site
  - Nijmegen, Holland, 6525 GA
    - Novartis Investigative Site
  - Venlo, Holland, 5912 BL
    - Novartis Investigative Site
- Gelderland
  - Arnhem, Gelderland, Holland, 6815 AD
    - Novartis Investigative Site
  - Doetinchem, Gelderland, Holland, 7009 BL
    - Novartis Investigative Site
- Gerlderland
  - Nijmegen, Gerlderland, Holland, 6532 SZ
    - Novartis Investigative Site
- North Brabant
  - 's-Hertogenbosch, North Brabant, Holland, 5223 GZ
    - Novartis Investigative Site
  - Tilburg, North Brabant, Holland, 5042 AD
    - Novartis Investigative Site
- North Holland
  - Amsterdam, North Holland, Holland, 1090 HM
    - Novartis Investigative Site
  - Amsterdam, North Holland, Holland, 1105 AZ
    - Novartis Investigative Site
  - Beverwijk, North Holland, Holland, 1942 LE
    - Novartis Investigative Site
- Overijssel
  - Deventer, Overijssel, Holland, 7416 SE
    - Novartis Investigative Site
- Provincie Friesland
  - Leeuwarden, Provincie Friesland, Holland, 8934 AD
    - Novartis Investigative Site
  - Sneek, Provincie Friesland, Holland, 8601 ZK
    - Novartis Investigative Site
- South Holland
  - Delft, South Holland, Holland, 2625 AD
    - Novartis Investigative Site
  - Dirksland, South Holland, Holland, 3247 BW
    - Novartis Investigative Site
  - Dordrecht, South Holland, Holland, 3318 AT
    - Novartis Investigative Site
  - The Hague, South Holland, Holland, 2545 AA
    - Novartis Investigative Site
Hong Kong
- - Hong Kong SAR, Hong Kong, 999077
    - Novartis Investigative Site
  - Kowloon, Hong Kong, 999077
    - Novartis Investigative Site
  - Shatin, Hong Kong, 999077
    - Novartis Investigative Site
- Hong Kong
  - Hong Kong, Hong Kong, Hong Kong, 999077
    - Novartis Investigative Site
Indien
- - Coimbatore, Indien, 641018
    - Novartis Investigative Site
  - Mysore, Indien, 570015
    - Novartis Investigative Site
  - New Delhi, Indien, 110029
    - Novartis Investigative Site
  - Uttarakhand, Indien, 263153
    - Novartis Investigative Site
- Andhra Pradesh
  - Guntur, Andhra Pradesh, Indien, 522001
    - Novartis Investigative Site
- Gujarat
  - Ahmedabad, Gujarat, Indien, 380054
    - Novartis Investigative Site
  - Ahmedabad, Gujarat, Indien, 380060
    - Novartis Investigative Site
- Karnataka
  - Bangalore, Karnataka, Indien, 560069
    - Novartis Investigative Site
  - Belagavi, Karnataka, Indien, 590010
    - Novartis Investigative Site
  - Mangalore, Karnataka, Indien, 575018
    - Novartis Investigative Site
  - Manipal, Karnataka, Indien, 576104
    - Novartis Investigative Site
  - Mysore, Karnataka, Indien, 570004
    - Novartis Investigative Site
- Kerala
  - Kochi, Kerala, Indien, 682041
    - Novartis Investigative Site
  - Kochi, Kerala, Indien, 682018
    - Novartis Investigative Site
- Maharashtra
  - Nagpur, Maharashtra, Indien, 440012
    - Novartis Investigative Site
  - Nagpur, Maharashtra, Indien, 441108
    - Novartis Investigative Site
  - Nashik, Maharashtra, Indien, 422005
    - Novartis Investigative Site
  - Pune, Maharashtra, Indien, 411004
    - Novartis Investigative Site
  - Pune, Maharashtra, Indien, 411045
    - Novartis Investigative Site
- National Capital Territory of Delhi
  - New Delhi, National Capital Territory of Delhi, Indien, 110060
    - Novartis Investigative Site
  - New Delhi, National Capital Territory of Delhi, Indien, 110002
    - Novartis Investigative Site
- Rajasthan
  - Ajmer, Rajasthan, Indien, 305001
    - Novartis Investigative Site
  - Bikaner, Rajasthan, Indien, 334003
    - Novartis Investigative Site
  - Jaipur, Rajasthan, Indien, 302001
    - Novartis Investigative Site
  - Jaipur, Rajasthan, Indien, 302020
    - Novartis Investigative Site
- Tamil Nadu
  - Chennai, Tamil Nadu, Indien, 600006
    - Novartis Investigative Site
  - Chennai, Tamil Nadu, Indien, 600116
    - Novartis Investigative Site
  - Coimbatore, Tamil Nadu, Indien, 641037
    - Novartis Investigative Site
  - Coimbatore, Tamil Nadu, Indien, 641009
    - Novartis Investigative Site
  - Madurai, Tamil Nadu, Indien, 625020
    - Novartis Investigative Site
- Uttar Pradesh
  - Kanpur, Uttar Pradesh, Indien, 208002
    - Novartis Investigative Site
  - Lucknow, Uttar Pradesh, Indien, 226003
    - Novartis Investigative Site
- Uttarakhand
  - Dehradun, Uttarakhand, Indien, 248001
    - Novartis Investigative Site
- Uttrakhand
  - Dehradun, Uttrakhand, Indien, 248104
    - Novartis Investigative Site
- West Bengal
  - Kolkata, West Bengal, Indien, 700020
    - Novartis Investigative Site
Israel
- - Beersheba, Israel, 8457108
    - Novartis Investigative Site
  - Haifa, Israel, 3104802
    - Novartis Investigative Site
  - Jerusalem, Israel, 9112001
    - Novartis Investigative Site
  - Nahariya, Israel, 2210001
    - Novartis Investigative Site
  - Poria – Neve Oved, Israel, 1528001
    - Novartis Investigative Site
  - Ramat Gan, Israel, 5265601
    - Novartis Investigative Site
  - Rehovot, Israel, 7661041
    - Novartis Investigative Site
  - Sefad, Israel, 1311300
    - Novartis Investigative Site
  - Tel Aviv, Israel, 6423906
    - Novartis Investigative Site
- Gush Dan
  - Holon, Gush Dan, Israel, 5845997
    - Novartis Investigative Site
Italien
- - Naples, Italien, 80131
    - Novartis Investigative Site
  - Naples, Italien, 80138
    - Novartis Investigative Site
- AN
  - Ancona, AN, Italien, 60128
    - Novartis Investigative Site
- BS
  - Brescia, BS, Italien, 25123
    - Novartis Investigative Site
- CE
  - Caserta, CE, Italien, 81100
    - Novartis Investigative Site
- CH
  - Chieti, CH, Italien, 66100
    - Novartis Investigative Site
- CZ
  - Catanzaro, CZ, Italien, 88100
    - Novartis Investigative Site
- FI
  - Florence, FI, Italien, 50134
    - Novartis Investigative Site
- GE
  - Chiavari, GE, Italien, 16043
    - Novartis Investigative Site
  - Genova, GE, Italien, 16132
    - Novartis Investigative Site
- IS
  - Pozzilli, IS, Italien, 86077
    - Novartis Investigative Site
- LT
  - Latina, LT, Italien, 04100
    - Novartis Investigative Site
- MB
  - Monza, MB, Italien, 20900
    - Novartis Investigative Site
- ME
  - Messina, ME, Italien, 98125
    - Novartis Investigative Site
- MI
  - Cinisello Balsamo, MI, Italien, 20092
    - Novartis Investigative Site
  - Milan, MI, Italien, 20162
    - Novartis Investigative Site
  - Milan, MI, Italien, 20132
    - Novartis Investigative Site
  - Milan, MI, Italien, 20122
    - Novartis Investigative Site
  - Milan, MI, Italien, 20138
    - Novartis Investigative Site
  - Milan, MI, Italien, 20100
    - Novartis Investigative Site
  - Milan, MI, Italien, 20157
    - Novartis Investigative Site
- MO
  - Modena, MO, Italien, 41126
    - Novartis Investigative Site
- PG
  - Perugia, PG, Italien, 06129
    - Novartis Investigative Site
- PI
  - Pisa, PI, Italien, 56124
    - Novartis Investigative Site
  - Pisa, PI, Italien, 56126
    - Novartis Investigative Site
- RM
  - Roma, RM, Italien, 00168
    - Novartis Investigative Site
  - Roma, RM, Italien, 00161
    - Novartis Investigative Site
- SI
  - Siena, SI, Italien, 53100
    - Novartis Investigative Site
Kina
- - Beijing, Kina, 100730
    - Novartis Investigative Site
  - Beijing, Kina, 100083
    - Novartis Investigative Site
  - Guangzhou, Kina, 510000
    - Novartis Investigative Site
  - Jining, Kina, 272011
    - Novartis Investigative Site
  - Shanghai, Kina, 200120
    - Novartis Investigative Site
  - Tianjin, Kina, 300140
    - Novartis Investigative Site
- Guangdong
  - Guangzhou, Guangdong, Kina, 510080
    - Novartis Investigative Site
- Guangxi
  - Nanning, Guangxi, Kina, 530022
    - Novartis Investigative Site
- Hebei
  - Cangzhou, Hebei, Kina, 061002
    - Novartis Investigative Site
  - Shijiazhuang, Hebei, Kina, 050000
    - Novartis Investigative Site
  - Tangshan, Hebei, Kina, 063000
    - Novartis Investigative Site
  - Xingtai, Hebei, Kina, 054000
    - Novartis Investigative Site
- Heilongjiang
  - Daqing, Heilongjiang, Kina, 163001
    - Novartis Investigative Site
  - Harbin, Heilongjiang, Kina, 150000
    - Novartis Investigative Site
  - Harbin, Heilongjiang, Kina, 150001
    - Novartis Investigative Site
- Henan
  - Luoyang, Henan, Kina, 471002
    - Novartis Investigative Site
  - Pingdingshan, Henan, Kina, 467000
    - Novartis Investigative Site
  - Zhengzhou, Henan, Kina, 450003
    - Novartis Investigative Site
- Hubei
  - Huangshi, Hubei, Kina, 435000
    - Novartis Investigative Site
  - Wuhan, Hubei, Kina, 430081
    - Novartis Investigative Site
- Hunan
  - Changsha, Hunan, Kina, 410011
    - Novartis Investigative Site
  - Changsha, Hunan, Kina, 410005
    - Novartis Investigative Site
- Inner Mongolia
  - Hohhot, Inner Mongolia, Kina, 010017
    - Novartis Investigative Site
- Jiangsu
  - Changzhou, Jiangsu, Kina, 213004
    - Novartis Investigative Site
  - Xuzhou, Jiangsu, Kina, 221003
    - Novartis Investigative Site
- Jiangxi
  - Nanchang, Jiangxi, Kina, 330009
    - Novartis Investigative Site
- Jilin
  - Tonghua, Jilin, Kina, 134000
    - Novartis Investigative Site
- Liaoning
  - Dalian, Liaoning, Kina, 116000
    - Novartis Investigative Site
  - Jinzhou, Liaoning, Kina, 121001
    - Novartis Investigative Site
  - Shenyang, Liaoning, Kina, 110016
    - Novartis Investigative Site
- Ningxia
  - Yinchuan, Ningxia, Kina, 750004
    - Novartis Investigative Site
- Shaanxi
  - Xianyang, Shaanxi, Kina, 712000
    - Novartis Investigative Site
- Shandong
  - Jinan, Shandong, Kina, 250021
    - Novartis Investigative Site
  - Jining, Shandong, Kina, 272000
    - Novartis Investigative Site
  - Qingdao, Shandong, Kina, 266011
    - Novartis Investigative Site
  - Zibo, Shandong, Kina, 255000
    - Novartis Investigative Site
- Shanxi
  - Xian, Shanxi, Kina, 710061
    - Novartis Investigative Site
- Tianjin Municipality
  - Tianjin, Tianjin Municipality, Kina, 300121
    - Novartis Investigative Site
- Zhejiang
  - Hangzhou, Zhejiang, Kina, 310006
    - Novartis Investigative Site
  - Hangzhou, Zhejiang, Kina, 310000
    - Novartis Investigative Site
  - Lishui, Zhejiang, Kina, 323020
    - Novartis Investigative Site
  - Wenzhou, Zhejiang, Kina, 325000
    - Novartis Investigative Site
Kroatien
- - Krapinske Toplice, Kroatien, 49217
    - Novartis Investigative Site
  - Opatija, Kroatien, 51410
    - Novartis Investigative Site
  - Osijek, Kroatien, 31000
    - Novartis Investigative Site
  - Pula, Kroatien, 52100
    - Novartis Investigative Site
  - Vinkovci, Kroatien, 32100
    - Novartis Investigative Site
  - Zagreb, Kroatien, 10000
    - Novartis Investigative Site
- City of Zagreb
  - Zagreb, City of Zagreb, Kroatien, 10000
    - Novartis Investigative Site
- County of Osijek-Baranja
  - Osijek, County of Osijek-Baranja, Kroatien, 31000
    - Novartis Investigative Site
- Croatia
  - Krapinske Toplice, Croatia, Kroatien, 49217
    - Novartis Investigative Site
  - Slavonski Brod, Croatia, Kroatien, 35000
    - Novartis Investigative Site
  - Zagreb, Croatia, Kroatien, 10000
    - Novartis Investigative Site
- Primorje-Gorski Kotar County
  - Rijeka, Primorje-Gorski Kotar County, Kroatien, 51000
    - Novartis Investigative Site
- Varaždin County
  - Varaždin, Varaždin County, Kroatien, 42000
    - Novartis Investigative Site
Letland
- - Daugavpils, Letland, LV-5417
    - Novartis Investigative Site
  - Kuldīga, Letland, LV-3300
    - Novartis Investigative Site
  - Liepāja, Letland, LV 3401
    - Novartis Investigative Site
  - Ogre, Letland, LV-5001
    - Novartis Investigative Site
  - Riga, Letland, LV 1002
    - Novartis Investigative Site
  - Riga, Letland, LV-1038
    - Novartis Investigative Site
  - Riga, Letland, LV-1001
    - Novartis Investigative Site
Litauen
- - Alytus, Litauen, LT-62386
    - Novartis Investigative Site
  - Kaunas, Litauen, LT-50009
    - Novartis Investigative Site
  - Kaunas, Litauen, 49449
    - Novartis Investigative Site
  - Panevezys, Litauen, 35144
    - Novartis Investigative Site
  - Vilnius, Litauen, LT-08406
    - Novartis Investigative Site
  - Šiauliai, Litauen, 76206
    - Novartis Investigative Site
- Kaunas County
  - Kaunas, Kaunas County, Litauen, LT-50177
    - Novartis Investigative Site
  - Kaunas, Kaunas County, Litauen, 50161
    - Novartis Investigative Site
- Klaipėda County
  - Klaipėda, Klaipėda County, Litauen, 92288
    - Novartis Investigative Site
  - Klaipėda, Klaipėda County, Litauen, 91131
    - Novartis Investigative Site
Malaysia
- - Johor Bahru, Malaysia, 80100
    - Novartis Investigative Site
  - Kuala Lumpur, Malaysia, 50400
    - Novartis Investigative Site
- Kedah
  - Alor Star, Kedah, Malaysia, 05460
    - Novartis Investigative Site
- Kelantan
  - Kota Bharu, Kelantan, Malaysia, 16150
    - Novartis Investigative Site
- Kuala Lumpur
  - Kuala Lumpur, Kuala Lumpur, Malaysia, 50586
    - Novartis Investigative Site
- Negeri Sembilan
  - Seremban, Negeri Sembilan, Malaysia, 70300
    - Novartis Investigative Site
- Perak
  - Ipoh, Perak, Malaysia, 30450
    - Novartis Investigative Site
  - Seri Manjung, Perak, Malaysia, 32040
    - Novartis Investigative Site
  - Taiping, Perak, Malaysia, 34000
    - Novartis Investigative Site
- Pulau Pinang
  - Timur Laut, Pulau Pinang, Malaysia, 11500
    - Novartis Investigative Site
- Sarawak
  - Kuching, Sarawak, Malaysia, 93586
    - Novartis Investigative Site
  - Miri, Sarawak, Malaysia, 98000
    - Novartis Investigative Site
- Selangor
  - Sungai Buloh, Selangor, Malaysia, 47000
    - Novartis Investigative Site
Mexico
- - Aguascalientes, Mexico, 20230
    - Novartis Investigative Site
  - Aguascalientes, Mexico, 20116
    - Novartis Investigative Site
  - Chihuahua City, Mexico, 31238
    - Novartis Investigative Site
  - Distrito Federal, Mexico, 14080
    - Novartis Investigative Site
  - Distrito Federal, Mexico, 03100
    - Novartis Investigative Site
  - Mexico City, Mexico, 06760
    - Novartis Investigative Site
  - Mexico D F, Mexico, 06720
    - Novartis Investigative Site
  - Oaxaca City, Mexico, 68020
    - Novartis Investigative Site
  - Veracruz, Mexico, 91900
    - Novartis Investigative Site
- Guanajuato
  - León, Guanajuato, Mexico, 37160
    - Novartis Investigative Site
- Hidalgo
  - Actopan, Hidalgo, Mexico, 42500
    - Novartis Investigative Site
- Jalisco
  - Guadalajara, Jalisco, Mexico, 44670
    - Novartis Investigative Site
  - Guadalajara, Jalisco, Mexico, 44260
    - Novartis Investigative Site
  - Guadalajara, Jalisco, Mexico, 44340
    - Novartis Investigative Site
- Mexico City
  - Gustavo Adolfo Madero, Mexico City, Mexico, 07020
    - Novartis Investigative Site
  - Mexico City, Mexico City, Mexico, 06700
    - Novartis Investigative Site
  - Tlalpan, Mexico City, Mexico, 14050
    - Novartis Investigative Site
- Morelos
  - Cuernavaca, Morelos, Mexico, 62250
    - Novartis Investigative Site
- Nuevo León
  - Monterrey, Nuevo León, Mexico, 64020
    - Novartis Investigative Site
  - Monterrey, Nuevo León, Mexico, 64060
    - Novartis Investigative Site
  - Monterrey, Nuevo León, Mexico, 64440
    - Novartis Investigative Site
  - Monterrey, Nuevo León, Mexico, 64610
    - Novartis Investigative Site
- San Luis Potosí
  - San Luis Potosí City, San Luis Potosí, Mexico, 78200
    - Novartis Investigative Site
- Sinaloa
  - Culiacán, Sinaloa, Mexico, 80230
    - Novartis Investigative Site
  - Culiacán, Sinaloa, Mexico, 80200
    - Novartis Investigative Site
- Tamaulipas
  - Tampico, Tamaulipas, Mexico, 89440
    - Novartis Investigative Site
- Yucatán
  - Mérida, Yucatán, Mexico, 97070
    - Novartis Investigative Site
Polen
- - Bialystok, Polen, 15-704
    - Novartis Investigative Site
  - Bydgoszcz, Polen, 85-065
    - Novartis Investigative Site
  - Bydgoszcz, Polen, 85-048
    - Novartis Investigative Site
  - Bygdoszcz, Polen, 85-605
    - Novartis Investigative Site
  - Chorzów, Polen, 41-500
    - Novartis Investigative Site
  - Elblag, Polen, 82-300
    - Novartis Investigative Site
  - Gdynia, Polen, 81-157
    - Novartis Investigative Site
  - Grudziądz, Polen, 86-300
    - Novartis Investigative Site
  - Katowice, Polen, 40-648
    - Novartis Investigative Site
  - Katowice, Polen, 40-081
    - Novartis Investigative Site
  - Katowice, Polen, 40-555
    - Novartis Investigative Site
  - Krakow, Polen, 31-501
    - Novartis Investigative Site
  - Krakow, Polen, 30-721
    - Novartis Investigative Site
  - Krakow, Polen, 31-216
    - Novartis Investigative Site
  - Lodz, Polen, 91-347
    - Novartis Investigative Site
  - Lodz, Polen, 91-034
    - Novartis Investigative Site
  - Myszków, Polen, 42-300
    - Novartis Investigative Site
  - Olsztyn, Polen, 10-165
    - Novartis Investigative Site
  - Piotrkow Trybunalski, Polen, 97-300
    - Novartis Investigative Site
  - Rzeszów, Polen, 35-055
    - Novartis Investigative Site
  - Tarnów, Polen, 33-100
    - Novartis Investigative Site
  - Torun, Polen, 87-100
    - Novartis Investigative Site
  - Warsaw, Polen, 00-215
    - Novartis Investigative Site
  - Wroclaw, Polen, 52-416
    - Novartis Investigative Site
  - Wroclaw, Polen, 53-673
    - Novartis Investigative Site
- Maloposkie
  - Krakow, Maloposkie, Polen, 31-271
    - Novartis Investigative Site
Portugal
- - Almada, Portugal, 2805-267
    - Novartis Investigative Site
  - Carnaxide, Portugal, 2799-523
    - Novartis Investigative Site
  - Coimbra, Portugal, 3004-561
    - Novartis Investigative Site
  - Lisbon, Portugal, 1649-035
    - Novartis Investigative Site
  - Lisbon, Portugal, 1500-650
    - Novartis Investigative Site
  - Matosinhos Municipality, Portugal, 4454-513
    - Novartis Investigative Site
  - Porto, Portugal, 4200-319
    - Novartis Investigative Site
  - Santa Maria da Feira, Portugal, 4520-211
    - Novartis Investigative Site
  - Setúbal, Portugal, 2910-549
    - Novartis Investigative Site
  - Vila Nova de Gaia, Portugal, 4434-502
    - Novartis Investigative Site
Puerto Rico
- - Ponce, Puerto Rico, 00717-1322
    - Research and Cardiovascular Corp
Rumænien
- - Brasov, Rumænien, 500283
    - Novartis Investigative Site
  - Brăila, Rumænien, 810325
    - Novartis Investigative Site
  - Bucharest, Rumænien, 022328
    - Novartis Investigative Site
  - Bucharest, Rumænien, 020475
    - Novartis Investigative Site
  - Bucharest, Rumænien, 011461
    - Novartis Investigative Site
  - Bucharest, Rumænien, 010496
    - Novartis Investigative Site
  - Bucharest, Rumænien, 010627
    - Novartis Investigative Site
  - Bucharest, Rumænien, 011055
    - Novartis Investigative Site
  - Bucharest, Rumænien, 021875
    - Novartis Investigative Site
  - Bucharest, Rumænien, 010192
    - Novartis Investigative Site
  - Cluj-Napoca, Rumænien, 400015
    - Novartis Investigative Site
  - Cluj-Napoca, Rumænien, 400001
    - Novartis Investigative Site
  - Iași, Rumænien, 700544
    - Novartis Investigative Site
  - Târgu Mureş, Rumænien, 540142
    - Novartis Investigative Site
  - Târgu Mureş, Rumænien, 540143
    - Novartis Investigative Site
- Argeş
  - Piteşti, Argeş, Rumænien, 110424
    - Novartis Investigative Site
- Bihor County
  - Oradea, Bihor County, Rumænien, 410001
    - Novartis Investigative Site
- Buzău
  - Buzău, Buzău, Rumænien, 120133
    - Novartis Investigative Site
- Cluj
  - Cluj-Napoca, Cluj, Rumænien, 400006
    - Novartis Investigative Site
- Dolj
  - Craiova, Dolj, Rumænien, 200513
    - Novartis Investigative Site
  - Craiova, Dolj, Rumænien, 200642
    - Novartis Investigative Site
- Dâmbovița County
  - Targoviste, Dâmbovița County, Rumænien, 130095
    - Novartis Investigative Site
- Ilfov
  - Afumaţi, Ilfov, Rumænien, 077010
    - Novartis Investigative Site
- Maramureş
  - Baia Mare, Maramureş, Rumænien, 430222
    - Novartis Investigative Site
  - Baia Mare, Maramureş, Rumænien, 430123
    - Novartis Investigative Site
- Mureș County
  - Târgu Mureş, Mureș County, Rumænien, 540124
    - Novartis Investigative Site
  - Târgu Mureş, Mureș County, Rumænien, 540136
    - Novartis Investigative Site
- Suceava
  - Suceava, Suceava, Rumænien, 720237
    - Novartis Investigative Site
- Timiș County
  - Timișoara, Timiș County, Rumænien, 300041
    - Novartis Investigative Site
  - Timișoara, Timiș County, Rumænien, 300480
    - Novartis Investigative Site
  - Timișoara, Timiș County, Rumænien, 300125
    - Novartis Investigative Site
  - Timișoara, Timiș County, Rumænien, 300362
    - Novartis Investigative Site
  - Timișoara, Timiș County, Rumænien, 300723
    - Novartis Investigative Site
Schweiz
- - Basel, Schweiz, 4031
    - Novartis Investigative Site
  - Bern, Schweiz, 3010
    - Novartis Investigative Site
  - Geneva, Schweiz, 1211
    - Novartis Investigative Site
  - Lucerne, Schweiz, 6000
    - Novartis Investigative Site
  - Lugano, Schweiz, 6900
    - Novartis Investigative Site
Singapore
- - Singapore, Singapore, 119074
    - Novartis Investigative Site
  - Singapore, Singapore, 529889
    - Novartis Investigative Site
  - Singapore, Singapore, 169608
    - Novartis Investigative Site
- Singapore
  - Singapore, Singapore, Singapore, 768828
    - Novartis Investigative Site
Slovakiet
- - Bardejov, Slovakiet, 085 01
    - Novartis Investigative Site
  - Bratislava, Slovakiet, 831 06
    - Novartis Investigative Site
  - Bratislava, Slovakiet, 833 48
    - Novartis Investigative Site
  - Bratislava, Slovakiet, 833 05
    - Novartis Investigative Site
  - Bratislava, Slovakiet, 831 01
    - Novartis Investigative Site
  - Bratislava, Slovakiet, 851 01
    - Novartis Investigative Site
  - Bratislava, Slovakiet, 813 69
    - Novartis Investigative Site
  - Bratislava, Slovakiet, 841 04
    - Novartis Investigative Site
  - Bratislava, Slovakiet, 841 08
    - Novartis Investigative Site
  - Dolný Kubín, Slovakiet, 026 01
    - Novartis Investigative Site
  - Košice, Slovakiet, 040 01
    - Novartis Investigative Site
  - Košice, Slovakiet, 040 11
    - Novartis Investigative Site
  - Kráľovský Chlmec, Slovakiet, 077 01
    - Novartis Investigative Site
  - Lučenec, Slovakiet, 984 01
    - Novartis Investigative Site
  - Malacky, Slovakiet, 901 22
    - Novartis Investigative Site
  - Nitra, Slovakiet, 949 01
    - Novartis Investigative Site
  - Nitra, Slovakiet, 950 01
    - Novartis Investigative Site
  - Nitra, Slovakiet, 949 11
    - Novartis Investigative Site
  - Nové Zámky, Slovakiet, 940 01
    - Novartis Investigative Site
  - Prešov, Slovakiet, 080 01
    - Novartis Investigative Site
  - Rožňava, Slovakiet, 048 01
    - Novartis Investigative Site
  - Svidník, Slovakiet, 089 01
    - Novartis Investigative Site
  - Trnava, Slovakiet, 917 01
    - Novartis Investigative Site
  - Ľubochňa, Slovakiet, 034 91
    - Novartis Investigative Site
  - Šamorín, Slovakiet, 931 01
    - Novartis Investigative Site
- Slovak Republic
  - Lučenec, Slovak Republic, Slovakiet, 984 01
    - Novartis Investigative Site
Spanien
- - A Coruña, Spanien, 15006
    - Novartis Investigative Site
  - A Coruña, Spanien, 15001
    - Novartis Investigative Site
  - Alicante, Spanien, 03700
    - Novartis Investigative Site
  - Almería, Spanien, 04009
    - Novartis Investigative Site
  - Barcelona, Spanien, 08035
    - Novartis Investigative Site
  - Barcelona, Spanien, 08041
    - Novartis Investigative Site
  - Barcelona, Spanien, 08025
    - Novartis Investigative Site
  - Barcelona, Spanien, 08022
    - Novartis Investigative Site
  - Barcelona, Spanien, 08028
    - Novartis Investigative Site
  - Barcelona, Spanien, 08023
    - Novartis Investigative Site
  - Córdoba, Spanien, 14004
    - Novartis Investigative Site
  - Huelva, Spanien, 21080
    - Novartis Investigative Site
  - Las Palmas GC, Spanien, 35010
    - Novartis Investigative Site
  - Madrid, Spanien, 28041
    - Novartis Investigative Site
  - Madrid, Spanien, 28034
    - Novartis Investigative Site
  - Madrid, Spanien, 28040
    - Novartis Investigative Site
  - Madrid, Spanien, 28009
    - Novartis Investigative Site
  - Madrid, Spanien, 28003
    - Novartis Investigative Site
  - Madrid, Spanien, 28010
    - Novartis Investigative Site
  - Málaga, Spanien, 29010
    - Novartis Investigative Site
  - Salamanca, Spanien, 37007
    - Novartis Investigative Site
  - Seville, Spanien, 41009
    - Novartis Investigative Site
  - Seville, Spanien, 41013
    - Novartis Investigative Site
  - Tarragona, Spanien, 43002
    - Novartis Investigative Site
  - Valencia, Spanien, 46014
    - Novartis Investigative Site
  - Zaragoza, Spanien, 50009
    - Novartis Investigative Site
- A Coruna
  - Ferrol, A Coruna, Spanien, 15405
    - Novartis Investigative Site
  - Santiago, A Coruna, Spanien, 15702
    - Novartis Investigative Site
  - Santiago Compostela, A Coruna, Spanien, 15706
    - Novartis Investigative Site
- Alicante
  - Elche, Alicante, Spanien, 03203
    - Novartis Investigative Site
- Andalusia
  - Granada, Andalusia, Spanien, 18014
    - Novartis Investigative Site
  - Huelva, Andalusia, Spanien, 21005
    - Novartis Investigative Site
  - Marbella, Andalusia, Spanien, 29600
    - Novartis Investigative Site
  - Málaga, Andalusia, Spanien, 29009
    - Novartis Investigative Site
- Balearic Islands
  - Mallorca, Balearic Islands, Spanien, 07198
    - Novartis Investigative Site
  - Palma, Balearic Islands, Spanien, 07011
    - Novartis Investigative Site
- Barcelona
  - Badalona, Barcelona, Spanien, 08916
    - Novartis Investigative Site
  - Centelles, Barcelona, Spanien, 08540
    - Novartis Investigative Site
  - La Roca del Vallès, Barcelona, Spanien, 08430
    - Novartis Investigative Site
  - Mataró, Barcelona, Spanien, 08303
    - Novartis Investigative Site
  - Sant Adrià de Besòs, Barcelona, Spanien, 08930
    - Novartis Investigative Site
  - Vic, Barcelona, Spanien, 08500
    - Novartis Investigative Site
  - el Prat de Llobregat, Barcelona, Spanien, 08820
    - Novartis Investigative Site
- Cadiz
  - Puerto Real, Cadiz, Spanien, 11510
    - Novartis Investigative Site
  - Sanlucar Barrameda, Cadiz, Spanien, 11540
    - Novartis Investigative Site
  - Villamartín, Cadiz, Spanien, 11650
    - Novartis Investigative Site
- Cantabria
  - Santander, Cantabria, Spanien, 39008
    - Novartis Investigative Site
- Catalonia
  - Barcelona, Catalonia, Spanien, 08003
    - Novartis Investigative Site
- Extremadura
  - Cáceres, Extremadura, Spanien, 10003
    - Novartis Investigative Site
- Girona
  - Peralada, Girona, Spanien, 17491
    - Novartis Investigative Site
- Las Palmas
  - Las Palmas de Gran C, Las Palmas, Spanien, 35016
    - Novartis Investigative Site
- Madrid
  - Boadilla del Monte, Madrid, Spanien, 28660
    - Novartis Investigative Site
  - Fuenlabrada, Madrid, Spanien, 28942
    - Novartis Investigative Site
  - Pozuelo de Alarcón, Madrid, Spanien, 28223
    - Novartis Investigative Site
- Malaga
  - Antequera, Malaga, Spanien, 29200
    - Novartis Investigative Site
  - Ronda, Malaga, Spanien, 29400
    - Novartis Investigative Site
- Murcia
  - El Palmar, Murcia, Spanien, 30120
    - Novartis Investigative Site
- Navarre
  - Pamplona, Navarre, Spanien, 31008
    - Novartis Investigative Site
- Santa Cruz De Tenerife
  - San Cristóbal de La Laguna, Santa Cruz De Tenerife, Spanien, 38320
    - Novartis Investigative Site
- Sevilla
  - Castilleja de la Cuesta, Sevilla, Spanien, 41950
    - Novartis Investigative Site
  - Lebrija, Sevilla, Spanien, 41570
    - Novartis Investigative Site
  - Utrera, Sevilla, Spanien, 41710
    - Novartis Investigative Site
- Tarragona
  - Reus, Tarragona, Spanien, 43204
    - Novartis Investigative Site
- Valencia
  - Alzira, Valencia, Spanien, 46600
    - Novartis Investigative Site
Sverige
- - Gothenburg, Sverige, 405 45
    - Novartis Investigative Site
  - Linköping, Sverige, 582 13
    - Novartis Investigative Site
  - Lund, Sverige, 222 21
    - Novartis Investigative Site
  - Solna, Sverige, 171 64
    - Novartis Investigative Site
  - Stockholm, Sverige, 111 57
    - Novartis Investigative Site
  - Uppsala, Sverige, 75237
    - Novartis Investigative Site
  - Västerås, Sverige, 721 89
    - Novartis Investigative Site
Sydafrika
- - Cape Town, Sydafrika, 7531
    - Novartis Investigative Site
  - Pretoria, Sydafrika, 0181
    - Novartis Investigative Site
  - Western Cape, Sydafrika, 7130
    - Novartis Investigative Site
- Eastern Cape
  - Port Elizabeth, Eastern Cape, Sydafrika, 6001
    - Novartis Investigative Site
- Free State
  - Bloemfontein, Free State, Sydafrika, 9301
    - Novartis Investigative Site
- Gauteng
  - Pretoria, Gauteng, Sydafrika, 0184
    - Novartis Investigative Site
- KwaZulu-Natal
  - KwaDukuza, KwaZulu-Natal, Sydafrika, 4449
    - Novartis Investigative Site
- Western Cape
  - Cape Town, Western Cape, Sydafrika, 7500
    - Novartis Investigative Site
  - Cape Town, Western Cape, Sydafrika, 7530
    - Novartis Investigative Site
  - George, Western Cape, Sydafrika, 6529
    - Novartis Investigative Site
  - Somerset West, Western Cape, Sydafrika, 7130
    - Novartis Investigative Site
- ZAF
  - Cape Town, ZAF, Sydafrika, 7570
    - Novartis Investigative Site
Taiwan
- - Changhua, Taiwan, 50006
    - Novartis Investigative Site
  - Kaohsiung City, Taiwan, 80756
    - Novartis Investigative Site
  - Taichung, Taiwan, 40447
    - Novartis Investigative Site
  - Tainan, Taiwan, 704
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  - Tainan, Taiwan, 71004
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  - Taipei, Taiwan, 11217
    - Novartis Investigative Site
  - Taipei, Taiwan, 110
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  - Taoyuan, Taiwan, 33305
    - Novartis Investigative Site
- Taiwan ROC
  - Taichung, Taiwan ROC, Taiwan, 40201
    - Novartis Investigative Site
Thailand
- - Bangkok, Thailand, 10330
    - Novartis Investigative Site
  - Bangkok, Thailand, 10700
    - Novartis Investigative Site
  - Bangkok, Thailand, 10400
    - Novartis Investigative Site
  - Chiang Mai, Thailand, 50200
    - Novartis Investigative Site
- Hat Yai
  - Songkhla, Hat Yai, Thailand, 90110
    - Novartis Investigative Site
- THA
  - Khon Kaen, THA, Thailand, 40002
    - Novartis Investigative Site
- Thailand
  - Muang, Thailand, Thailand, 12120
    - Novartis Investigative Site
Tjekkiet
- - Brandýs nad Labem, Tjekkiet, 250 01
    - Novartis Investigative Site
  - Brno, Tjekkiet, 602 00
    - Novartis Investigative Site
  - Chlumec nad Cidlinou, Tjekkiet, 503 51
    - Novartis Investigative Site
  - Hlučín, Tjekkiet, 748 01
    - Novartis Investigative Site
  - Hodonín, Tjekkiet, 695 01
    - Novartis Investigative Site
  - Jihlava, Tjekkiet, 586 01
    - Novartis Investigative Site
  - Kolín, Tjekkiet, 280 20
    - Novartis Investigative Site
  - Liberec, Tjekkiet, 46063
    - Novartis Investigative Site
  - Mariánské Lázně, Tjekkiet, 353 01
    - Novartis Investigative Site
  - Náchod, Tjekkiet, 547 01
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  - Olomouc, Tjekkiet, 772 00
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  - Ostrava, Tjekkiet, 710 00
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  - Pardubice, Tjekkiet, 532 03
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  - Plzen Bory, Tjekkiet, 301 00
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  - Prague, Tjekkiet, 128 08
    - Novartis Investigative Site
  - Prague, Tjekkiet, 100 34
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  - Prague, Tjekkiet, 158 00
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  - Prague, Tjekkiet, 148 00
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  - Prague, Tjekkiet, 104 00
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  - Trutnov, Tjekkiet, 460 63
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  - Uherské Hradiště, Tjekkiet, 686 01
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  - Zlín, Tjekkiet, 760 01
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  - Znojmo, Tjekkiet, 669 02
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  - Ústí nad Labem, Tjekkiet, 400 01
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  - Český Krumlov, Tjekkiet, 381 01
    - Novartis Investigative Site
- CZE
  - Ostrava, CZE, Tjekkiet, 728 80
    - Novartis Investigative Site
- Czech Republic
  - Louny, Czech Republic, Tjekkiet, 440 01
    - Novartis Investigative Site
  - Ostrava, Czech Republic, Tjekkiet, 725 27
    - Novartis Investigative Site
  - Ústí nad Labem, Czech Republic, Tjekkiet, 400 01
    - Novartis Investigative Site
- Olomouc Region
  - Přerov, Olomouc Region, Tjekkiet, 750 02
    - Novartis Investigative Site
- Zabreh
  - Ostrava, Zabreh, Tjekkiet, 700 30
    - Novartis Investigative Site
Tyrkiet (Türkiye)
- - Izmir, Tyrkiet (Türkiye), 35100
    - Novartis Investigative Site
- Balcova
  - Izmir, Balcova, Tyrkiet (Türkiye), 35340
    - Novartis Investigative Site
- Bayrakli
  - Izmir, Bayrakli, Tyrkiet (Türkiye), 35540
    - Novartis Investigative Site
- Bilkent-Cankaya
  - Ankara, Bilkent-Cankaya, Tyrkiet (Türkiye), 06800
    - Novartis Investigative Site
- Fatih
  - Istanbul, Fatih, Tyrkiet (Türkiye), 34098
    - Novartis Investigative Site
- Kadikoy
  - Istanbul, Kadikoy, Tyrkiet (Türkiye), 34668
    - Novartis Investigative Site
- Kinikli
  - Denizli, Kinikli, Tyrkiet (Türkiye), 20070
    - Novartis Investigative Site
- Kucukcekmece
  - Istanbul, Kucukcekmece, Tyrkiet (Türkiye), 34303
    - Novartis Investigative Site
- Melikgazi
  - Kayseri, Melikgazi, Tyrkiet (Türkiye), 38039
    - Novartis Investigative Site
- Mentese
  - Muğla, Mentese, Tyrkiet (Türkiye), 48000
    - Novartis Investigative Site
- Odunpazari
  - Eskişehir, Odunpazari, Tyrkiet (Türkiye), 26040
    - Novartis Investigative Site
- Sehitkamil
  - Gaziantep, Sehitkamil, Tyrkiet (Türkiye), 27310
    - Novartis Investigative Site
- Sihhiye-Altindag
  - Ankara, Sihhiye-Altindag, Tyrkiet (Türkiye), 06230
    - Novartis Investigative Site
- Yenisehir
  - Mersin, Yenisehir, Tyrkiet (Türkiye), 33110
    - Novartis Investigative Site
- Zeytinburnu
  - Istanbul, Zeytinburnu, Tyrkiet (Türkiye), 34010
    - Novartis Investigative Site
Ungarn
- - Balatonfüred, Ungarn, 8230
    - Novartis Investigative Site
  - Budapest, Ungarn, 1145
    - Novartis Investigative Site
  - Budapest, Ungarn, 1083
    - Novartis Investigative Site
  - Budapest, Ungarn, 1097
    - Novartis Investigative Site
  - Budapest, Ungarn, 1134
    - Novartis Investigative Site
  - Budapest, Ungarn, 1036
    - Novartis Investigative Site
  - Budapest, Ungarn, 1132
    - Novartis Investigative Site
  - Debrecen, Ungarn, 4027
    - Novartis Investigative Site
  - Hatvan, Ungarn, 3000
    - Novartis Investigative Site
  - Hosszúhetény, Ungarn, 7694
    - Novartis Investigative Site
  - Mosanmagyarovar, Ungarn, 9200
    - Novartis Investigative Site
  - Nyíregyháza, Ungarn, 4400
    - Novartis Investigative Site
  - Pécs, Ungarn, 7623
    - Novartis Investigative Site
  - Szeged, Ungarn, 6725
    - Novartis Investigative Site
  - Szekszárd, Ungarn, 7100
    - Novartis Investigative Site
- Pest County
  - Budapest, Pest County, Ungarn, 1132
    - Novartis Investigative Site
- Zala County
  - Zalaegerszeg, Zala County, Ungarn, 8900
    - Novartis Investigative Site
Vietnam
- - Hanoi, Vietnam, 100000
    - Novartis Investigative Site
  - Ho Chi Minh City, Vietnam, 700000
    - Novartis Investigative Site
Østrig
- - Braunau am Inn, Østrig, 5280
    - Novartis Investigative Site
  - Graz, Østrig, 8036
    - Novartis Investigative Site
  - Linz, Østrig, 4021
    - Novartis Investigative Site
  - Vienna, Østrig, 1190
    - Novartis Investigative Site

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

40 år til 79 år (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Beskrivelse

Inklusionskriterier:

Med en øget risiko for en første MACE (dvs. ingen tidligere større ASCVD-hændelse), defineret som en af følgende:
1. Bevis for aterosklerotisk koronararteriesygdom (CAD) på computertomografi (CT) eller invasivt koronar angiogram defineret som en koronararteriestenose ≥20 % men <50 % i venstre hovedkranspulsåre eller stenose ≥20 % men <70 % i enhver større epicardial koronararterie, eller
2. Koronararteriecalcium (CAC) score opnået ved CT-scanning ≥100 Agatston-enheder, eller
3. Høj 10-års ASCVD-risiko ≥20 %, eller
4. Mellem 10-årig ASCVD-risiko 7,5% - <20% med mindst 2 risikoforstærkende faktorer.
Hvis der er på en baggrundslipidsænkende behandling, skal dosis være stabil i mindst 4 uger før screeningsbesøget, og deltageren skal være villig til at forblive på denne baggrundsterapi i hele undersøgelsens varighed.
LDL-C ≥70 mg/dL (≥1,81 mmol/L), men <190 mg/dL (<4,91 mmol/L) ved screeningsbesøget.

Ekskluderingskriterier:

Historien om større ASCVD-begivenhed.
Anamnese med eller planlagt iskæmi-drevet revaskularisering i en koronar eller ekstrakoronar arteriel seng før randomisering
Fravær af koronar aterosklerose på et CT-angiogram eller et invasivt koronar-angiogram i de 2 år forud for randomisering
Koronararteriecalcium (CAC) score på 0 opnået i de 2 år forud for randomisering
Aktiv leversygdom eller leverdysfunktion
Tidligere, nuværende eller planlagt behandling med et monoklonalt antistof (mAb) rettet mod proprotein convertase subtilisin/kexin type 9 (PCSK9) (f.eks. evolocumab, alirocumab)
Gravide eller ammende (ammende) kvinder
Kvinder i den fødedygtige alder, medmindre de bruger effektive præventionsmetoder, mens de tager undersøgelsesbehandling

Andre protokoldefinerede inklusions-/udelukkelseskriterier kan være gældende.

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Forebyggelse
Tildeling: Randomiseret
Interventionel model: Parallel tildeling
Maskning: Firedobbelt

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Placebo komparator: Placebo Matchende placebo i 1,5 ml fyldt sprøjte. Randomiseret i forholdet 1:1 med Inclisiran.	Medicin: Placebo i 1,5 ml Matchende placebo i 1,5 ml opløsning til injektion
Eksperimentel: Inclisiran natrium 300mg Inclisiran natrium 300 mg i 1,5 ml injektionsvæske, opløsning (subkutan) i fyldt injektionssprøjte. Randomiseret i et 1:1-forhold med matchende placebo	Medicin: Inclisiran natrium 300 mg (svarende til 284 mg inclisiran) i 1,5 ml Subkutan injektion i fyldt injektionssprøjte. Andre navne: KJX839

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Tid til den første forekomst af 4P-MACE Tidsramme: Tid til den første forekomst af 4P-MACE (op til ca. 75 måneder)	4-punkts-større uønskede kardiovaskulære hændelser (4P-MACE): sammensat af kardiovaskulær død, ikke-fatalt myokardieinfarkt, ikke-fatalt iskæmisk slagtilfælde og akut koronar revaskularisering.	Tid til den første forekomst af 4P-MACE (op til ca. 75 måneder)

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Tid til den første forekomst af 3P-MACE Tidsramme: Tid til den første forekomst af 3P-MACE (op til ca. 75 måneder)	3-punkts-større uønskede kardiovaskulære hændelser (3P-MACE): sammensat af kardiovaskulær død, ikke-fatalt myokardieinfarkt og ikke-fatalt iskæmisk slagtilfælde)	Tid til den første forekomst af 3P-MACE (op til ca. 75 måneder)
Samlet antal første eller gentagne CV-begivenheder (4P MACE) Tidsramme: op til 75 måneder	Total 4P-MACE (sammensætning af kardiovaskulær død, ikke-fatalt myokardieinfarkt, ikke-fatalt iskæmisk slagtilfælde og presserende koronar revaskularisering)	op til 75 måneder
Samlet antal første eller gentagne CV-begivenheder (3P MACE) Tidsramme: op til 75 måneder	Total 3P-MACE (sammensætning af kardiovaskulær død, ikke-fatalt myokardieinfarkt og ikke-fatalt iskæmisk slagtilfælde)	op til 75 måneder
Tid til forekomsten af kardiovaskulær død Tidsramme: Tid til kardiovaskulær død (op til 75 måneder)	CV død defineres som død som følge af kardiovaskulære hændelser.	Tid til kardiovaskulær død (op til 75 måneder)
Tid til indtræden af dødsfald uanset årsag Tidsramme: Tid til dødelighed af alle årsager (op til 75 måneder)	Dødelighed af alle årsager er død, uanset årsag.	Tid til dødelighed af alle årsager (op til 75 måneder)

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Novartis Pharmaceuticals

Efterforskere

Studieleder: Novartis Pharmaceuticals, Novartis Pharmaceuticals

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

9. marts 2023

Primær færdiggørelse (Anslået)

16. april 2029

Studieafslutning (Anslået)

16. april 2029

Datoer for studieregistrering

Først indsendt

13. februar 2023

Først indsendt, der opfyldte QC-kriterier

13. februar 2023

Først opslået (Faktiske)

22. februar 2023

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

4. september 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

3. september 2026

Sidst verificeret

1. september 2026

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

CKJX839D12302

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

IPD-planbeskrivelse

Novartis er forpligtet til at dele med kvalificerede eksterne forskere, adgang til data på patientniveau og understøttende kliniske dokumenter fra kvalificerede undersøgelser. Disse anmodninger gennemgås og godkendes af et uafhængigt bedømmelsespanel på grundlag af videnskabelig fortjeneste. Alle opgivne data er anonymiseret for at respektere privatlivets fred for patienter, der har deltaget i forsøget i overensstemmelse med gældende love og regler.

Tilgængeligheden af denne forsøgsdata er i overensstemmelse med kriterierne og processen beskrevet på www.clinicalstudydatarequest.com

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

En undersøgelse af Inclisiran til forebyggelse af kardiovaskulære hændelser hos højrisikopatienter med primær forebyggelse.

En randomiseret, dobbeltblind, placebokontrolleret multicenterundersøgelse til evaluering af effekten af ​​Inclisiran på forebyggelse af alvorlige uønskede kardiovaskulære hændelser hos højrisikopatienter med primær forebyggelse (VICTORION-1 PREVENT)

Studieoversigt

Status

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsestype

Tilmelding (Faktiske)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Efterforskere

Datoer for undersøgelser

Studer store datoer

Studiestart (Faktiske)

Primær færdiggørelse (Anslået)

Studieafslutning (Anslået)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Faktiske)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

IPD-planbeskrivelse

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Studerer et amerikansk FDA-reguleret enhedsprodukt

En randomiseret, dobbeltblind, placebokontrolleret multicenterundersøgelse til evaluering af effekten af Inclisiran på forebyggelse af alvorlige uønskede kardiovaskulære hændelser hos højrisikopatienter med primær forebyggelse (VICTORION-1 PREVENT)