Intrinsic Capacity and Functional Ability Monitoring With an Integrated Data Eco-System for Healthy Ageing. (ISHA)

February 13, 2024 updated by: Prof. Ivan Bautmans

Feasibility and Usability of Intrinsic Capacity Monitoring With an Integrated Data Eco-System for Healthy Ageing, and Its Association With Health Outcomes in Older Patients Undergoing Rehabilitation and in Older Nursing Home Residents.

In this study, 120 older adults (aged 65 years or older) either patients undergoing rehabilitation or older nursing home residents will be provided with an Eforto® device and the eco-System for Healthy Ageing (ISHA) mobile application to self-monitor intrinsic capacity for 4 months (if needed with assistance by an (in)formal caregiver). Preferably, the participants will use their own smartphone because mitigating smartphone-use-related issues.

The aims of the study are:

to evaluate the usability and feasibility of self-monitoring intrinsic capacity by using the ISHA system in rehabilitation and nursing home settings.
to investigate if changes and variability in intrinsic capacity as measured with ISHA are related to changes in functional ability and quality of life.
to explore individual trajectories of intrinsic capacity with the ISHA system.

Study Overview

Status

Not yet recruiting

Conditions

Frailty

Intervention / Treatment

Device: ISHA

Detailed Description

Investigational device:

The ISHA digital eco-system (class IIa investigational medical device).

ISHA consists of 3 components:

An Eforto® device: a handheld grip work (GW) hardware device, composed of a rubber bulb, to be compressed by the user and plastic enclosure that holds the electronic components such as a pressure sensor, battery, and connectivity. A mouthpiece can be attached for respiratory capacity monitoring.
The Eforto® system was developed based on approximatively 20 years of scientific research on handgrip muscle fatigability performed by the Frailty in Ageing research department (see https://fria.research.vub.be/) and in collaboration with top-level international partners.
The Eforto® system allows self-assessment of muscle fatigability and self-perceived fatigue in older adults and functions as a monitoring tool for intrinsic capacity. It is a small device, easy to use, and suitable for home measurements as well as hospital settings. When used correctly, the measurements cause no discomfort and can be performed repeatedly. The Eforto® device connects to a smartphone application that provides verbal test instructions to the participant. The app will guide the participant during the test and automatically provide motivational cues via audio. The test results are aggregated and stored in a cloud platform where the researcher can manage subjects, access the test data and export it for further analysis.
Mobile application that ensures connectivity and collection of data from the Eforto® device and by which multiple guided tests for the locomotor (maximal grip strength, respiratory muscle strength, muscle fatigue resistance test & self-perceived fatigue questionnaire), sensory (hearing test (signal to noise technology) & vision test (rotating E test), cognitive (orientation test, object naming from description, animal naming & 10-words immediate and delayed recall), and psychological (resilience questionnaire) domains of intrinsic capacity can be completed. The app allows offline data collection and to synchronize with the third component, the remote monitoring platform. It serves as an interactive guidance and can be used by the subject/patient at home or assisted by a (formal or informal) caregiver.
The remote monitoring platform serves mainly as a dashboard for monitoring the older end-users. Its main purpose is to centralize and monitor the collected data.

Procedures:

The study will be approved by the institutional review board's and all participants will sign informed consent.

After informed consent is given, the eligibility assessment and T0 (baseline) measurements will take place. These measurements will be re-assessed after 2 months and 4 months.

During this test moments the participant will be asked to perform the ISHA-tests (intrinsic domains: vitality, locomotor, sensory, cognitive and psychological). Other tests that will be assessed are: anthropometry (body weight & height and waist & hip circumference), health status (medical history, Center for Epidemiologic Studies Depression scale (CES-D), Mini Mental State Examination (MMSE), fall incidents, hospital admissions, Mini Nutritional Assessment (MNA) and orthostatic test), Frailty (Fried Criteria), functional dependency tests (Montreal Cognitive Assessment (MOCA), basic activity of daily living (ADL) (Katz), instrumental ADL (Lawton) and Short Physical Performance Test (SPPB)), questionnaires (Sarcopenia Quality of life questionnaire (SarQol), Eq-5D-5L, International Physical Activity Questionnaire (IPAQ), health-economic questionnaire and general health questions) and technical problem/ usability, feasibility and expectations questionnaires. In the context of eligible check, the smartphone experiences and personal data e.g. sex, birth day date, living situation will be asked.

After an individual information session with training on the ISHA test battery and instructions for ISHA use in self-test mode, the participant will be instructed to perform the ISHA measurements for 4 months at their home (if needed with assistance by an (in)formal caregiver). Preferentially, the healthcare professional (occupational therapist, physical therapist, study nurse) will install the ISHA application on the smartphone of the participant. If during the individual information session, the participant is unable to correctly operate the ISHA tool, the healthcare professional will explore together with the participant whether a (informal or formal) caregiver could aid, and eventually the participant will be re-invited together with his/her informal caregiver for another information/training session. If correct use of the ISHA system by the participant and/or assistance by a caregiver is impossible, the participant will be excluded for further participation in the study.

The self-test measurements will be continued for 4 months or until withdrawal of the participant. The self-tests will be performed:

weekly on 2 consecutive days per week for vitality capacity;
once every two weeks for locomotor capacity, and
once every month for sensory, cognitive, and psychological capacity.

The application will give a reminder to the participant every time he/she needs to do the ISHA measurements.

During the study, participants will be contacted every month by a researcher to register any changes in health situation as well as technical issues encountered during the self-testing.

Study Type

Observational

Enrollment (Estimated)

120

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Name: Ivan Bautmans, Prof. Dr.
Phone Number: +32 (0)2 477 42 07
Email: Ivan.Bautmans@vub.be

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

Older Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Non-Probability Sample

Study Population

Patients undergoing rehabilitation and nursing home residents, all aged 65 years or older.

Description

Inclusion Criteria:

Aged 65 years or older.
Patients living independently at home and undergoing rehabilitation, or older persons living in the residential care community (in a nursing home or in assisted housing).
Being able to operate the basic functions of a smartphone (if needed with assistance by an informal caregiver): using a smartphone at least for calls, and minimum 1 other application.
Understanding Dutch.

Exclusion Criteria: Being unable to participate in the assessments due to:

Being unable to perform the physical (self)tests (e.g., unable to stand up or walk);
Being unable to understand the test instructions;
Functional disability of the dominant upper extremity (paresis/paralysis, tremor or recent surgery);
Patients undergoing neurological rehabilitation.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Number of groups / cohorts

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Leiehome vzw Participant recruitment entails including persons aged 65 years or older living in an assisted housing or a nursing home.	Device: ISHA Participants will be provided with an Eforto® device and ISHA mobile application to self-monitor intrinsic capacity for 4 months (if needed with assistance by an (in)formal caregiver).
University Hospital Antwerp/University of Antwerp Participant recruitment entails including persons aged 65 years or older undergoing rehabilitation at University Hospital Antwerp.	Device: ISHA Participants will be provided with an Eforto® device and ISHA mobile application to self-monitor intrinsic capacity for 4 months (if needed with assistance by an (in)formal caregiver).

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Potential technical problems of the ISHA system Time Frame: Week 1	A checklist of potential technical problems (12 questions) related to the eforto® system that can occur during the study. Options for answer: yes or no; if 'yes' => clarify the technical problem.	Week 1
Potential technical problems of the ISHA system Time Frame: Week 2	A checklist of potential technical problems (12 questions) related to the eforto® system that can occur during the study. Options for answer: yes or no; if 'yes' => clarify the technical problem.	Week 2
Potential technical problems of the ISHA system Time Frame: Week 3	A checklist of potential technical problems (12 questions) related to the eforto® system that can occur during the study. Options for answer: yes or no; if 'yes' => clarify the technical problem.	Week 3
Potential technical problems of the ISHA system Time Frame: Week 4	A checklist of potential technical problems (12 questions) related to the eforto® system that can occur during the study. Options for answer: yes or no; if 'yes' => clarify the technical problem.	Week 4
Potential technical problems of the ISHA system Time Frame: Week 5	A checklist of potential technical problems (12 questions) related to the eforto® system that can occur during the study. Options for answer: yes or no; if 'yes' => clarify the technical problem.	Week 5
Potential technical problems of the ISHA system Time Frame: Week 6	A checklist of potential technical problems (12 questions) related to the eforto® system that can occur during the study. Options for answer: yes or no; if 'yes' => clarify the technical problem.	Week 6
Potential technical problems of the ISHA system Time Frame: Week 7	A checklist of potential technical problems (12 questions) related to the eforto® system that can occur during the study. Options for answer: yes or no; if 'yes' => clarify the technical problem.	Week 7
Potential technical problems of the ISHA system Time Frame: Week 8	A checklist of potential technical problems (12 questions) related to the eforto® system that can occur during the study. Options for answer: yes or no; if 'yes' => clarify the technical problem.	Week 8
Potential technical problems of the ISHA system Time Frame: Week 9	A checklist of potential technical problems (12 questions) related to the eforto® system that can occur during the study. Options for answer: yes or no; if 'yes' => clarify the technical problem.	Week 9
Potential technical problems of the ISHA system Time Frame: Week 10	A checklist of potential technical problems (12 questions) related to the eforto® system that can occur during the study. Options for answer: yes or no; if 'yes' => clarify the technical problem.	Week 10
Potential technical problems of the ISHA system Time Frame: Week 11	A checklist of potential technical problems (12 questions) related to the eforto® system that can occur during the study. Options for answer: yes or no; if 'yes' => clarify the technical problem.	Week 11
Potential technical problems of the ISHA system Time Frame: Week 12	A checklist of potential technical problems (12 questions) related to the eforto® system that can occur during the study. Options for answer: yes or no; if 'yes' => clarify the technical problem.	Week 12
Potential technical problems of the ISHA system Time Frame: Week 13	A checklist of potential technical problems (12 questions) related to the eforto® system that can occur during the study. Options for answer: yes or no; if 'yes' => clarify the technical problem.	Week 13
Potential technical problems of the ISHA system Time Frame: Week 14	A checklist of potential technical problems (12 questions) related to the eforto® system that can occur during the study. Options for answer: yes or no; if 'yes' => clarify the technical problem.	Week 14
Potential technical problems of the ISHA system Time Frame: Week 15	A checklist of potential technical problems (12 questions) related to the eforto® system that can occur during the study. Options for answer: yes or no; if 'yes' => clarify the technical problem.	Week 15
Potential technical problems of the ISHA system Time Frame: Week 16	A checklist of potential technical problems (12 questions) related to the eforto® system that can occur during the study. Options for answer: yes or no; if 'yes' => clarify the technical problem.	Week 16
Experiences with ISHA (usability, feasibility and acceptability outcome) Time Frame: End of the study (week 16)	An self-reported questionnaire (19 questions) based on the System Usability Scale (SUS). Options for answer: 1-5. 1 is 'Strongly disagree', 5 is 'Strongly agree'.	End of the study (week 16)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The correlation between the changes in intrinsic capacity as measured with ISHA and the changes in functional ability (gait speed; m/s) measured with SPPB Time Frame: Baseline	Mobility is assessed by the SPPB, including gait speed(m/s) via the 4-meter test(s). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	Baseline
The correlation between the changes in intrinsic capacity as measured with ISHA and the changes in functional ability (gait speed; m/s) measured with SPPB Time Frame: 2 months	Mobility is assessed by the SPPB, including gait speed(m/s) via the 4-meter test(s). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	2 months
The correlation between the changes in intrinsic capacity as measured with ISHA and the changes in functional ability (gait speed; m/s) measured with SPPB Time Frame: 4 months	Mobility is assessed by the SPPB, including gait speed(m/s) via the 4-meter test(s). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	4 months
The correlation between the variability in intrinsic capacity as measured with ISHA and the changes in functional ability (gait speed; m/s) measured with SPPB Time Frame: Baseline	Mobility is assessed by the SPPB, including gait speed(m/s) via the 4-meter test(s). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	Baseline
The correlation between the variability in intrinsic capacity as measured with ISHA and the changes in functional ability (gait speed; m/s) measured with SPPB Time Frame: 2 months	Mobility is assessed by the SPPB, including gait speed(m/s) via the 4-meter test(s). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	2 months
The correlation between the variability in intrinsic capacity as measured with ISHA and the changes in functional ability (gait speed; m/s) measured with SPPB Time Frame: 4 months	Mobility is assessed by the SPPB, including gait speed(m/s) via the 4-meter test(s). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	4 months
The correlation between the changes in intrinsic capacity as measured with ISHA and the changes in functional ability (balance) measured with SPPB Time Frame: Baseline	Mobility is assessed by the SPPB, including balance, measured via the balance test. Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	Baseline
The correlation between the changes in intrinsic capacity as measured with ISHA and the changes in functional ability (balance) measured with SPPB Time Frame: 2 months	Mobility is assessed by the SPPB, including balance, measured via the balance test. Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	2 months
The correlation between the changes in intrinsic capacity as measured with ISHA and the changes in functional ability (balance) measured with SPPB Time Frame: 4 months	Mobility is assessed by the SPPB, including balance, measured via the balance test. Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	4 months
The correlation between the variability in intrinsic capacity as measured with ISHA and the changes in functional ability (balance) measured with SPPB Time Frame: Baseline	Mobility is assessed by the SPPB, including balance, measured via the balance test. Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	Baseline
The correlation between the variability in intrinsic capacity as measured with ISHA and the changes in functional ability (balance) measured with SPPB Time Frame: 2 months	Mobility is assessed by the SPPB, including balance, measured via the balance test. Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	2 months
The correlation between the variability in intrinsic capacity as measured with ISHA and the changes in functional ability (balance) measured with SPPB Time Frame: 4 months	Mobility is assessed by the SPPB, including balance, measured via the balance test. Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	4 months
The correlation between the changes in intrinsic capacity as measured with ISHA and the changes in functional ability (5-times sit-to stand (s)) measured with SPPB Time Frame: Baseline	Mobility is assessed by the SPPB, including 5-times sit-to stand tests(s). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	Baseline
The correlation between the changes in intrinsic capacity as measured with ISHA and the changes in functional ability (5-times sit-to stand (s)) measured with SPPB Time Frame: 2 months	Mobility is assessed by the SPPB, including 5-times sit-to stand tests(s). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	2 months
The correlation between the changes in intrinsic capacity as measured with ISHA and the changes in functional ability (5-times sit-to stand (s)) measured with SPPB Time Frame: 4 months	Mobility is assessed by the SPPB, including 5-times sit-to stand tests(s). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	4 months
The correlation between the variability in intrinsic capacity as measured with ISHA and the changes in functional ability (5-times sit-to stand (s)) measured with SPPB Time Frame: Baseline	Mobility is assessed by the SPPB, including 5-times sit-to stand tests(s). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	Baseline
The correlation between the variability in intrinsic capacity as measured with ISHA and the changes in functional ability (5-times sit-to stand (s)) measured with SPPB Time Frame: 2 months	Mobility is assessed by the SPPB, including 5-times sit-to stand tests(s). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	2 months
The correlation between the variability in intrinsic capacity as measured with ISHA and the changes in functional ability (5-times sit-to stand (s)) measured with SPPB Time Frame: 4 months	Mobility is assessed by the SPPB, including 5-times sit-to stand tests(s). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	4 months
The correlation between the changes in intrinsic capacity as measured with ISHA and the changes in functional ability measured with MoCa (0-30/30, the higher the better cognition) Time Frame: Baseline	Cognition will be assessed by the MoCa(0-30/30), a tool covering different domains. Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	Baseline
The correlation between the changes in intrinsic capacity as measured with ISHA and the changes in functional ability measured with MoCa (0-30/30, the higher the better cognition) Time Frame: 2 months	Cognition will be assessed by the MoCa(0-30/30), a tool covering different domains. Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	2 months
The correlation between the changes in intrinsic capacity as measured with ISHA and the changes in functional ability measured with MoCa (0-30/30, the higher the better cognition) Time Frame: 4 months	Cognition will be assessed by the MoCa(0-30/30), a tool covering different domains. Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	4 months
The correlation between the variability in intrinsic capacity as measured with ISHA and the changes in functional ability measured with MoCa (0-30/30, the higher the better cognition) Time Frame: Baseline	Cognition will be assessed by the MoCa(0-30/30), a tool covering different domains. Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	Baseline
The correlation between the variability in intrinsic capacity as measured with ISHA and the changes in functional ability measured with MoCa (0-30/30, the higher the better cognition) Time Frame: 2 months	Cognition will be assessed by the MoCa(0-30/30), a tool covering different domains. Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	2 months
The correlation between the variability in intrinsic capacity as measured with ISHA and the changes in functional ability measured with MoCa (0-30/30, the higher the better cognition) Time Frame: 4 months	Cognition will be assessed by the MoCa(0-30/30), a tool covering different domains. Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	4 months
The correlation between the changes in intrinsic capacity as measured with ISHA and the changes in functional ability measured with Katz (6-24/24, the higher, more dependent) Time Frame: Baseline	Dependency in basic activities of daily living will be scored on the Katz scale (6-24/24). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	Baseline
The correlation between the changes in intrinsic capacity as measured with ISHA and the changes in functional ability measured with Katz (6-24/24, the higher, more dependent) Time Frame: 2 months	Dependency in basic activities of daily living will be scored on the Katz scale (6-24/24). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	2 months
The correlation between the changes in intrinsic capacity as measured with ISHA and the changes in functional ability measured with Katz (6-24/24, the higher, more dependent) Time Frame: 4 months	Dependency in basic activities of daily living will be scored on the Katz scale (6-24/24). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	4 months
The correlation between the variability in intrinsic capacity as measured with ISHA and the changes in functional ability measured with Katz (6-24/24, the higher, more dependent) Time Frame: Baseline	Dependency in basic activities of daily living will be scored on the Katz scale (6-24/24). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	Baseline
The correlation between the variability in intrinsic capacity as measured with ISHA and the changes in functional ability measured with Katz (6-24/24, the higher, more dependent) Time Frame: 2 months	Dependency in basic activities of daily living will be scored on the Katz scale (6-24/24). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	2 months
The correlation between the variability in intrinsic capacity as measured with ISHA and the changes in functional ability measured with Katz (6-24/24, the higher, more dependent) Time Frame: 4 months	Dependency in basic activities of daily living will be scored on the Katz scale (6-24/24). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	4 months
The correlation between the changes in intrinsic capacity as measured with ISHA and the changes in functional ability measured with Lawton (9-27/27, the higher, more independent) Time Frame: Baseline	Dependency in instrumental activities of daily living will be scored on Lawton scale (9-27/27). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	Baseline
The correlation between the changes in intrinsic capacity as measured with ISHA and the changes in functional ability measured with Lawton (9-27/27, the higher, more independent) Time Frame: 2 months	Dependency in instrumental activities of daily living will be scored on Lawton scale (9-27/27). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	2 months
The correlation between the changes in intrinsic capacity as measured with ISHA and the changes in functional ability measured with Lawton (9-27/27, the higher, more independent) Time Frame: 4 months	Dependency in instrumental activities of daily living will be scored on Lawton scale (9-27/27). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	4 months
The correlation between the variability in intrinsic capacity as measured with ISHA and the changes in functional ability measured with Lawton (9-27/27, the higher, more independent) Time Frame: Baseline	Dependency in instrumental activities of daily living will be scored on Lawton scale (9-27/27). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	Baseline
The correlation between the variability in intrinsic capacity as measured with ISHA and the changes in functional ability measured with Lawton (9-27/27, the higher, more independent) Time Frame: 2 months	Dependency in instrumental activities of daily living will be scored on Lawton scale (9-27/27). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	2 months
The correlation between the variability in intrinsic capacity as measured with ISHA and the changes in functional ability measured with Lawton (9-27/27, the higher, more independent) Time Frame: 4 months	Dependency in instrumental activities of daily living will be scored on Lawton scale (9-27/27). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	4 months
The correlation between the changes in intrinsic capacity as measured with ISHA and the changes in quality of life (Qol) measured with SarQol (short form, 14 items: 4-point Likert Scale: 0-100/100, the higher, the better Qol) Time Frame: Baseline	Qol will be scored on SarQol (short form, 14 items: 0-100/100, the higher, the better Qol) Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	Baseline
The correlation between the changes in intrinsic capacity as measured with ISHA and the changes in Qol measured with SarQol (short form, 14 items: 4-point Likert Scale: 0-100/100, the higher, the better Qol) Time Frame: 2 months	Qol will be scored on SarQol (short form, 14 items: 0-100/100, the higher, the better Qol) Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	2 months
The correlation between the changes in intrinsic capacity as measured with ISHA and the changes in Qol measured with SarQol (short form, 14 items: 4-point Likert Scale: 0-100/100, the higher, the better Qol) Time Frame: 4 months	Qol will be scored on SarQol (short form, 14 items: 0-100/100, the higher, the better Qol) Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	4 months
The correlation between the variability in intrinsic capacity as measured with ISHA and the changes in Qol measured with SarQol (short form, 14 items: 4-point Likert Scale: 0-100/100, the higher, the better Qol) Time Frame: Baseline	Qol will be scored on SarQol (short form, 14 items: 0-100/100, the higher, the better Qol) Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	Baseline
The correlation between the variability in intrinsic capacity as measured with ISHA and the changes in Qol measured with SarQol (short form, 14 items: 4-point Likert Scale: 0-100/100, the higher, the better Qol) Time Frame: 2 months	Qol will be scored on SarQol (short form, 14 items: 0-100/100, the higher, the better Qol) Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	2 months
The correlation between the variability in intrinsic capacity as measured with ISHA and the changes in Qol measured with SarQol (short form, 14 items: 4-point Likert Scale: 0-100/100, the higher, the better Qol) Time Frame: 4 months	Qol will be scored on SarQol (short form, 14 items: 0-100/100, the higher, the better Qol) Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	4 months
The correlation between the changes in intrinsic capacity as measured with ISHA and the changes in Qol measured with Eq-5D-5L (0 no problem, 5 extreme problems + visual analogue scale(VAS) 0-100/100, the higher the better Qol). Time Frame: Baseline	Qol will be scored on Eq-5D-5L(0-35 & VAS 0 (worst Qol) to 100 (best Qol)). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	Baseline
The correlation between the changes in intrinsic capacity as measured with ISHA and the changes in Qol measured with Eq-5D-5L (0 no problem, 5 extreme problems + visual analogue scale(VAS) 0-100/100, the higher the better Qol). Time Frame: 2 months	Qol will be scored on Eq-5D-5L(0-35 & VAS 0 (worst Qol) to 100 (best Qol)). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	2 months
The correlation between the changes in intrinsic capacity as measured with ISHA and the changes in Qol measured with Eq-5D-5L (0 no problem, 5 extreme problems + visual analogue scale(VAS) 0-100/100, the higher the better Qol). Time Frame: 4 months	Qol will be scored on Eq-5D-5L(0-35 & VAS 0 (worst Qol) to 100 (best Qol)). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	4 months
The correlation between the variability in intrinsic capacity as measured with ISHA and the changes in Qol measured with Eq-5D-5L (0 no problem, 5 extreme problems + visual analogue scale(VAS) 0-100/100, the higher the better Qol). Time Frame: Baseline	Qol will be scored on Eq-5D-5L(0-35 & VAS 0 (worst Qol) to 100 (best Qol)). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	Baseline
The correlation between the variability in intrinsic capacity as measured with ISHA and the changes in Qol measured with Eq-5D-5L (0 no problem, 5 extreme problems + visual analogue scale(VAS) 0-100/100, the higher the better Qol). Time Frame: 2 months	Qol will be scored on Eq-5D-5L(0-35 & VAS 0 (worst Qol) to 100 (best Qol)). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	2 months
The correlation between the variability in intrinsic capacity as measured with ISHA and the changes in Qol measured with Eq-5D-5L (0 no problem, 5 extreme problems + visual analogue scale(VAS) 0-100/100, the higher the better Qol). Time Frame: 4 months	Qol will be scored on Eq-5D-5L(0-35 & VAS 0 (worst Qol) to 100 (best Qol)). Vitality capacity: Maximal grip strength(kPa) Respiratory muscle strength(cmH2O) Muscle fatigue resistance(s) Self-perceived fatigue questionnaire(Question(Q) 1: 1 Not tired, 7 Extremely tired; Q2: 1 No I don't agree, 7 Yes I agree & MFI: 0 Not fatigue, 5 Fatigue) Locomotor capacity: Timed up and go(s) 4-meter gait speed(m/s) Balance test(progressive standing: first 2 tests: 0 Impossible, 1 Holding for 10s; last test: 0 Impossible, 1 Holding for >3s-<9s, 2 holding for 10s) 30-second chair stand(n) Sensory capacity: Hearing test(signal to noise technology) Vision test(rotating E test) Cognitive capacity: Orientation test(0 Incorrect, 1 Correct) Object naming from description(0 Incorrect, 1 Correct) Verbal fluency(n) 10-words immediate & delayed recall(0 Incorrect, 1 Correct) Psychological capacity: Resilience questionnaire(1 Strongly disagree, 5 Strongly agree)	4 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Prof. Ivan Bautmans

Collaborators

University Hospital, Antwerp

Universiteit Antwerpen

INNOVIRIS

AAL

Leiehome vzw

Investigators

Principal Investigator: Ivan Bautmans, Prof. Dr., VUB

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

April 1, 2024

Primary Completion (Estimated)

April 1, 2025

Study Completion (Estimated)

April 1, 2025

Study Registration Dates

First Submitted

January 12, 2024

First Submitted That Met QC Criteria

February 13, 2024

First Posted (Estimated)

February 21, 2024

Study Record Updates

Last Update Posted (Estimated)

February 21, 2024

Last Update Submitted That Met QC Criteria

February 13, 2024

Last Verified

February 1, 2024

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

ISHA

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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More Information

Terms related to this study

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Plan for Individual participant data (IPD)

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Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product

Clinical Trials on Frailty

Clinical Trials on ISHA

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