Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin (Prevent-HF)

May 15, 2026 updated by: AstraZeneca

A Phase III, Randomised, Placebo-controlled, Event-driven Study to Evaluate the Effect of Baxdrostat in Combination With Dapagliflozin Compared With Dapagliflozin Alone on the Risk of Incident Heart Failure and Cardiovascular Death

Participants include men and women ≥ 40 years of age with T2DM, established CV disease, a history of HTN with an SBP of at least 130 mmHg at screening, who meet the predefined serum potassium level, and with at least one additional risk factor for HF.

The study will include an optional pre-screening period to facilitate sites' identification of potentially eligible participants to enter the full screening assessments. Participants will not be required to visit the site and no informed consent is required for the optional pre-screening period. The pre-screening assessments do not replace the full screening tests at Visit 1.

Upon entering the screening period, all consented participants (after signature of screening ICF) will be screened during an up to 14-day screening period. Participants who meet all screening inclusion/exclusion criteria but are not treated with SGLT2i or are treated for less than 4 weeks will enter a run-in period with dapagliflozin 10 mg once daily for at least 4 weeks (and not more than 6 weeks) before randomisation.

Site visits will take place at approximately 2-, 4-, 8-, 16-, and 34-weeks following randomisation. Thereafter visits will occur approximately every 4 months.

The study closure procedures will be initiated when the predetermined number of the first secondary endpoint events (ie, the composite of hospitalisation for HF or CV death) is predicted to have occurred i.e., the PACD.

In case of premature discontinuation of the blinded study intervention, participants will remain in the study. Unless a participant meets the dapagliflozin specific discontinuation criteria, they will continue to receive open label dapagliflozin 10 mg. It is important that the scheduled study visits and data collection continue according to the study protocol.

Study Overview

Status

Recruiting

Conditions

Heart Failure

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

11300

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Name: AstraZeneca Clinical Study Information Center
Phone Number: 1-877-240-9479
Email: information.center@astrazeneca.com

Study Locations

Argentina
- - Buenos Aires, Argentina, C1425AGC
    - Recruiting
    - Research Site
  - CABA, Argentina, C1119ACN
    - Recruiting
    - Research Site
  - CABA, Argentina, C1056ABH
    - Recruiting
    - Research Site
  - CABA, Argentina, C1120AAC
    - Recruiting
    - Research Site
  - Caba, Argentina, C1128AAF
    - Recruiting
    - Research Site
  - Ciudad de Buenos Aires, Argentina, C1428DCO
    - Recruiting
    - Research Site
  - Córdoba, Argentina, 5000
    - Not yet recruiting
    - Research Site
  - Córdoba, Argentina, X5003DCP
    - Recruiting
    - Research Site
  - La Plata, Argentina, B1904
    - Not yet recruiting
    - Research Site
  - Mar del Plata, Argentina, B7600GNY
    - Recruiting
    - Research Site
  - Mar del Plata, Argentina, B7600FZN
    - Not yet recruiting
    - Research Site
  - Rosario, Argentina, S2000PBJ
    - Recruiting
    - Research Site
  - Rosario, Argentina, 2000
    - Recruiting
    - Research Site
  - San Nicolás, Argentina, B2900DMH
    - Recruiting
    - Research Site
  - San Nicolás de los Arroyos, Argentina, B2900DPA
    - Not yet recruiting
    - Research Site
  - San Vicente, Argentina, 5006
    - Recruiting
    - Research Site
  - Santa Fe, Argentina, S3000FWO
    - Recruiting
    - Research Site
Australia
- - Adelaide, Australia, 5000
    - Recruiting
    - Research Site
  - Castle Hill, Australia, 2154
    - Recruiting
    - Research Site
  - Coffs Harbour, Australia, 02450
    - Not yet recruiting
    - Research Site
  - Elizabeth Vale, Australia, 5112
    - Recruiting
    - Research Site
  - Fremantle, Australia, 6160
    - Recruiting
    - Research Site
  - Geelong, Australia, 3220
    - Recruiting
    - Research Site
  - Kingswood, Australia, 2747
    - Terminated
    - Research Site
  - Leabrook, Australia, 5068
    - Recruiting
    - Research Site
  - Maroubra, Australia, 2035
    - Recruiting
    - Research Site
  - Merewether, Australia, 2291
    - Recruiting
    - Research Site
  - Milton, Australia, 4064
    - Recruiting
    - Research Site
  - Mulgrave, Australia, 3170
    - Withdrawn
    - Research Site
  - Osborne Park, Australia, 6017
    - Recruiting
    - Research Site
  - Rockhampton, Australia, 4700
    - Recruiting
    - Research Site
  - Wollongong, Australia, 2500
    - Recruiting
    - Research Site
Brazil
- - Belém, Brazil, 66073-005
    - Recruiting
    - Research Site
  - Blumenau, Brazil, 89010-022
    - Recruiting
    - Research Site
  - Bragança Paulista, Brazil, 12916-542
    - Recruiting
    - Research Site
  - Brasília, Brazil, 71625-009
    - Recruiting
    - Research Site
  - Campina Grande do Sul, Brazil, 83.430-000
    - Recruiting
    - Research Site
  - Campinas, Brazil, 13060-080
    - Recruiting
    - Research Site
  - Campinas, Brazil, 13060-904
    - Recruiting
    - Research Site
  - Curitiba, Brazil, 80810-050
    - Recruiting
    - Research Site
  - Curitiba, Brazil, 80030-480
    - Recruiting
    - Research Site
  - Juiz de Fora, Brazil, 36033-318
    - Recruiting
    - Research Site
  - Natal, Brazil, 59020-035
    - Recruiting
    - Research Site
  - Porto Alegre, Brazil, 91350-200
    - Recruiting
    - Research Site
  - Porto Alegre, Brazil, 90160-093
    - Recruiting
    - Research Site
  - Porto Alegre, Brazil, 9061-000
    - Recruiting
    - Research Site
  - Porto Alegre, Brazil, 90630-165
    - Recruiting
    - Research Site
  - Rio de Janeiro, Brazil, 20241-180
    - Recruiting
    - Research Site
  - São José do Rio Preto, Brazil, 15090-000
    - Recruiting
    - Research Site
  - São José dos Campos, Brazil, 12230-001
    - Recruiting
    - Research Site
  - São Paulo, Brazil, 05403-000
    - Recruiting
    - Research Site
  - São Paulo, Brazil, 04012-180
    - Recruiting
    - Research Site
  - São Paulo, Brazil, 01236-030
    - Recruiting
    - Research Site
  - São Paulo, Brazil, 01228-000
    - Withdrawn
    - Research Site
  - Tatuí, Brazil, 18270-170
    - Recruiting
    - Research Site
Bulgaria
- - Haskovo, Bulgaria, 6300
    - Recruiting
    - Research Site
  - Panagyurishte, Bulgaria, 4500
    - Recruiting
    - Research Site
  - Petrich, Bulgaria, 2850
    - Withdrawn
    - Research Site
  - Pleven, Bulgaria, 5800
    - Recruiting
    - Research Site
  - Pleven, Bulgaria, 5804
    - Withdrawn
    - Research Site
  - Plovdiv, Bulgaria, 4003
    - Recruiting
    - Research Site
  - Rousse, Bulgaria, 7000
    - Recruiting
    - Research Site
  - Shumen, Bulgaria, 9700
    - Recruiting
    - Research Site
  - Sofia, Bulgaria, 1000
    - Recruiting
    - Research Site
  - Sofia, Bulgaria, 1431
    - Recruiting
    - Research Site
  - Sofia, Bulgaria, 1527
    - Recruiting
    - Research Site
  - Sofia, Bulgaria, 1309
    - Recruiting
    - Research Site
  - Sofia, Bulgaria, 1618
    - Recruiting
    - Research Site
  - Sofia, Bulgaria, 1680
    - Recruiting
    - Research Site
  - Sofia, Bulgaria, 1404
    - Recruiting
    - Research Site
  - Stara Zagora, Bulgaria, 6003
    - Recruiting
    - Research Site
  - Varna, Bulgaria, 9000
    - Recruiting
    - Research Site
Canada
- Alberta
  - Calgary, Alberta, Canada, T2V 4J2
    - Recruiting
    - Research Site
  - Calgary, Alberta, Canada, T2H 2G4
    - Recruiting
    - Research Site
  - Sherwood Park, Alberta, Canada, T8H 0N2
    - Recruiting
    - Research Site
- British Columbia
  - Abbotsford British Columbia, British Columbia, Canada, V2S 0C2
    - Recruiting
    - Research Site
- New Brunswick
  - Moncton, New Brunswick, Canada, E1C 2Z3
    - Recruiting
    - Research Site
  - Saint John, New Brunswick, Canada, E2L 4L2
    - Recruiting
    - Research Site
- Newfoundland and Labrador
  - St. John's, Newfoundland and Labrador, Canada, A1B 3V6
    - Recruiting
    - Research Site
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 1V7
    - Recruiting
    - Research Site
  - Sydney, Nova Scotia, Canada, B1P 1P3
    - Recruiting
    - Research Site
- Ontario
  - Cambridge, Ontario, Canada, N1R 6V6
    - Withdrawn
    - Research Site
  - Guelph, Ontario, Canada, N1H 1B1
    - Recruiting
    - Research Site
  - Hamilton, Ontario, Canada, L8J 0B6
    - Recruiting
    - Research Site
  - Hamilton, Ontario, Canada, L8L 5G4
    - Recruiting
    - Research Site
  - Markham, Ontario, Canada, L3S 0A2
    - Recruiting
    - Research Site
  - Newmarket, Ontario, Canada, L3Y 2P6
    - Recruiting
    - Research Site
  - North York, Ontario, Canada, M6B 3H7
    - Recruiting
    - Research Site
  - North York, Ontario, Canada, M9N 1W4
    - Withdrawn
    - Research Site
  - Oakville, Ontario, Canada, L6K 3W7
    - Recruiting
    - Research Site
  - Ottawa, Ontario, Canada, K2J 0V2
    - Recruiting
    - Research Site
  - Sarnia, Ontario, Canada, N7T 4X3
    - Recruiting
    - Research Site
  - Scarborough Village, Ontario, Canada, M1B 4Z8
    - Not yet recruiting
    - Research Site
  - Toronto, Ontario, Canada, M5B 1W8
    - Recruiting
    - Research Site
  - Toronto, Ontario, Canada, M6G 1M2
    - Recruiting
    - Research Site
  - Toronto, Ontario, Canada, M4G 3E8
    - Recruiting
    - Research Site
- Quebec
  - Laval, Quebec, Canada, H7T 2P5
    - Recruiting
    - Research Site
  - Lévis, Quebec, Canada, G6V 9H4
    - Recruiting
    - Research Site
  - Mirabel, Quebec, Canada, J7J 2K8
    - Recruiting
    - Research Site
  - Montreal, Quebec, Canada, H1T 1C8
    - Recruiting
    - Research Site
  - Montreal, Quebec, Canada, H4A 3T2
    - Recruiting
    - Research Site
  - Québec, Quebec, Canada, G1V 4G5
    - Recruiting
    - Research Site
  - Québec, Quebec, Canada, G1G 5X1
    - Recruiting
    - Research Site
  - Saint-Charles-Borromée, Quebec, Canada, J6E 6J2
    - Recruiting
    - Research Site
  - Sherbrooke, Quebec, Canada, J1H 5N4
    - Recruiting
    - Research Site
  - Terrebonne, Quebec, Canada, J6X 4P7
    - Recruiting
    - Research Site
  - Trois-Rivières, Quebec, Canada, G9A 4P3
    - Recruiting
    - Research Site
- Saskatchewan
  - Regina, Saskatchewan, Canada, S4P 0W5
    - Not yet recruiting
    - Research Site
China
- - Baotou, China, 14010
    - Recruiting
    - Research Site
  - Beijing, China, 100029
    - Withdrawn
    - Research Site
  - Beijing, China, 100029
    - Recruiting
    - Research Site
  - Beijing, China, 100050
    - Recruiting
    - Research Site
  - Changchun, China, 130021
    - Recruiting
    - Research Site
  - Changchun, China, 130033
    - Recruiting
    - Research Site
  - Changde, China, 415000
    - Recruiting
    - Research Site
  - Changsha, China, 410011
    - Recruiting
    - Research Site
  - Changsha, China, 410015
    - Recruiting
    - Research Site
  - Changzhou, China, 272100
    - Recruiting
    - Research Site
  - Chengdu, China, 610000
    - Recruiting
    - Research Site
  - Chengdu, China, 610041
    - Recruiting
    - Research Site
  - Chifeng, China, 024000
    - Recruiting
    - Research Site
  - Chongqing, China, 400042
    - Recruiting
    - Research Site
  - Chongqing, China, 400014
    - Recruiting
    - Research Site
  - Guangzhou, China, 510100
    - Recruiting
    - Research Site
  - Guangzhou, China, 511486
    - Recruiting
    - Research Site
  - Harbin, China, 150000
    - Recruiting
    - Research Site
  - Hefei, China, 230001
    - Withdrawn
    - Research Site
  - Hengyang, China, 421001
    - Recruiting
    - Research Site
  - Heze, China, 274099
    - Recruiting
    - Research Site
  - Huangshi, China, 435000
    - Recruiting
    - Research Site
  - Huizhou, China, 516002
    - Recruiting
    - Research Site
  - Jinan, China, 250001
    - Recruiting
    - Research Site
  - Jining, China, 272006
    - Recruiting
    - Research Site
  - Kaifeng, China, 475000
    - Recruiting
    - Research Site
  - Liaocheng, China, 252000
    - Recruiting
    - Research Site
  - Linhai, China, 317000
    - Recruiting
    - Research Site
  - Linyi, China, 276003
    - Recruiting
    - Research Site
  - Lishui, China, 323000
    - Recruiting
    - Research Site
  - Luoyang, China, 471000
    - Recruiting
    - Research Site
  - Luoyang, China, 471001
    - Recruiting
    - Research Site
  - Meihekou, China, 135022
    - Recruiting
    - Research Site
  - Nanchang, China, 330009
    - Recruiting
    - Research Site
  - Nanjing, China, 210008
    - Recruiting
    - Research Site
  - Nantong, China, 226001
    - Recruiting
    - Research Site
  - Nanyang, China, 473000
    - Recruiting
    - Research Site
  - Panjin, China, 124009
    - Recruiting
    - Research Site
  - Pingxiang, China, 337055
    - Recruiting
    - Research Site
  - Sanya, China, 572000
    - Recruiting
    - Research Site
  - Shanghai, China, 200240
    - Recruiting
    - Research Site
  - Shanghai, China, 201114
    - Recruiting
    - Research Site
  - Shenyang, China, 110016
    - Recruiting
    - Research Site
  - Siping, China, 136000
    - Recruiting
    - Research Site
  - Suzhou, China, 215004
    - Recruiting
    - Research Site
  - Taiyuan, China, 030024
    - Recruiting
    - Research Site
  - Tianjin, China, 300000
    - Recruiting
    - Research Site
  - Wenzhou, China, 325000
    - Recruiting
    - Research Site
  - Wuhan, China, 430010
    - Recruiting
    - Research Site
  - Wuhan, China, 430060
    - Recruiting
    - Research Site
  - Xi'an, China, 710061
    - Recruiting
    - Research Site
  - Xi'an, China, 710068
    - Recruiting
    - Research Site
  - Xianyang, China, 750004
    - Recruiting
    - Research Site
  - Xuzhou, China, 221009
    - Recruiting
    - Research Site
  - Yinchuan, China, 750004
    - Recruiting
    - Research Site
  - Zhumadian, China, 463000
    - Recruiting
    - Research Site
  - Zigong, China, 643000
    - Recruiting
    - Research Site
Czechia
- - Benešov, Czechia, 256 01
    - Recruiting
    - Research Site
  - Brandýs nad Labem, Czechia, 250 01
    - Recruiting
    - Research Site
  - Brno, Czechia, 639 00
    - Recruiting
    - Research Site
  - Brno, Czechia, 603 00
    - Recruiting
    - Research Site
  - Broumov, Czechia, 55001
    - Recruiting
    - Research Site
  - Chlumec nad Cidlinou, Czechia, 503 51
    - Recruiting
    - Research Site
  - Hodonín, Czechia, 695 01
    - Recruiting
    - Research Site
  - Humpolec, Czechia, 396 01
    - Recruiting
    - Research Site
  - Jílové u Prahy, Czechia, 254 01
    - Recruiting
    - Research Site
  - Krnov, Czechia, 794 01
    - Recruiting
    - Research Site
  - Olomouc, Czechia, 772 00
    - Completed
    - Research Site
  - Ostrava, Czechia, 702 00
    - Recruiting
    - Research Site
  - Pilsen, Czechia, 301 00
    - Recruiting
    - Research Site
  - Police nad Metují, Czechia, 549 54
    - Recruiting
    - Research Site
  - Prague, Czechia, 12808
    - Recruiting
    - Research Site
  - Prague, Czechia, 190 14
    - Recruiting
    - Research Site
  - Prague, Czechia, 104 00
    - Recruiting
    - Research Site
  - Prague, Czechia, 149 00
    - Recruiting
    - Research Site
  - Prague, Czechia, 150 00
    - Recruiting
    - Research Site
  - Prague, Czechia, 101 00
    - Recruiting
    - Research Site
Denmark
- - Aarhus, Denmark, 8200
    - Recruiting
    - Research Site
  - Aarhus N, Denmark, 8200
    - Recruiting
    - Research Site
  - Copenhagen, Denmark, 2300
    - Recruiting
    - Research Site
  - Esbjerg, Denmark, 6700
    - Recruiting
    - Research Site
  - Frederiksberg, Denmark, 2000
    - Recruiting
    - Research Site
  - Gistrup, Denmark, 9260
    - Recruiting
    - Research Site
  - Herlev, Denmark, 2730
    - Recruiting
    - Research Site
  - Herning, Denmark, 7400
    - Recruiting
    - Research Site
  - Hillerød, Denmark, 3400
    - Recruiting
    - Research Site
  - Hjørring, Denmark, 9800
    - Recruiting
    - Research Site
  - Holbæk, Denmark, 4300
    - Recruiting
    - Research Site
  - Hvidovre, Denmark, 2650
    - Recruiting
    - Research Site
  - Roskilde, Denmark, 4000
    - Recruiting
    - Research Site
  - Slagelse, Denmark, DK-4200
    - Recruiting
    - Research Site
  - Svendborg, Denmark, 5700
    - Recruiting
    - Research Site
  - Viborg, Denmark, 8800
    - Recruiting
    - Research Site
France
- - Amiens, France, 80054
    - Recruiting
    - Research Site
  - Angers, France, 49933
    - Recruiting
    - Research Site
  - Aurillac, France, 15002
    - Recruiting
    - Research Site
  - Besançon, France, 25030
    - Recruiting
    - Research Site
  - Bobigny, France, 93000
    - Recruiting
    - Research Site
  - Bois-Guillaume, France, 76230
    - Recruiting
    - Research Site
  - Brest, France, 29200
    - Recruiting
    - Research Site
  - Caen, France, 14033
    - Recruiting
    - Research Site
  - Cholet, France, 49300
    - Recruiting
    - Research Site
  - Clermont-Ferrand, France, 63000
    - Recruiting
    - Research Site
  - Colombes, France, 92700
    - Recruiting
    - Research Site
  - Corbeil-Essonnes, France, 91106
    - Recruiting
    - Research Site
  - Dijon, France, 2100
    - Recruiting
    - Research Site
  - La Roche-sur-Yon, France, 85925
    - Recruiting
    - Research Site
  - La Rochelle, France, 17000
    - Recruiting
    - Research Site
  - Le Coudray, France, 28630
    - Recruiting
    - Research Site
  - Le Creusot, France, 71206
    - Withdrawn
    - Research Site
  - Lyon, France, 69007
    - Recruiting
    - Research Site
  - Marseille, France, 13385
    - Recruiting
    - Research Site
  - Montpellier, France, 34295
    - Recruiting
    - Research Site
  - Nantes, France, 44093
    - Recruiting
    - Research Site
  - Narbonne, France, 11108
    - Recruiting
    - Research Site
  - Paris, France, 75010
    - Recruiting
    - Research Site
  - Paris, France, 75018
    - Recruiting
    - Research Site
  - Paris, France, 75908
    - Recruiting
    - Research Site
  - Pierre-Bénite, France, 69495
    - Recruiting
    - Research Site
  - Toulouse, France, 31059
    - Recruiting
    - Research Site
  - Vandœuvre-lès-Nancy, France, 54511
    - Recruiting
    - Research Site
  - Villeurbanne, France, 69100
    - Recruiting
    - Research Site
Germany
- - Aachen, Germany, 52074
    - Recruiting
    - Research Site
  - Amberg, Germany, 92224
    - Recruiting
    - Research Site
  - Bad Homburg, Germany, 61348
    - Withdrawn
    - Research Site
  - Bad Oeynhausen, Germany, 32545
    - Recruiting
    - Research Site
  - Bamberg, Germany, 96049
    - Recruiting
    - Research Site
  - Bechhofen, Germany, 66894
    - Recruiting
    - Research Site
  - Berlin, Germany, 13187
    - Recruiting
    - Research Site
  - Berlin, Germany, 13353
    - Recruiting
    - Research Site
  - Berlin, Germany, 12203
    - Recruiting
    - Research Site
  - Berlin, Germany, 10367
    - Withdrawn
    - Research Site
  - Berlin, Germany, 10789
    - Recruiting
    - Research Site
  - Berlin, Germany, 13597
    - Recruiting
    - Research Site
  - Bochum, Germany, 44789
    - Recruiting
    - Research Site
  - Bochum, Germany, 44869
    - Recruiting
    - Research Site
  - Brandenburg an der Havel, Germany, 14770
    - Recruiting
    - Research Site
  - Brandenburg an der Havel, Germany, 14776
    - Recruiting
    - Research Site
  - Bremen, Germany, 28277
    - Recruiting
    - Research Site
  - Cologne, Germany, 51065
    - Recruiting
    - Research Site
  - Cologne, Germany, 51069
    - Withdrawn
    - Research Site
  - Deggingen, Germany, 73326
    - Recruiting
    - Research Site
  - Dresden, Germany, 01277
    - Recruiting
    - Research Site
  - Dresden, Germany, 01069
    - Withdrawn
    - Research Site
  - Elsterwerda, Germany, 04910
    - Recruiting
    - Research Site
  - Essen, Germany, 45136
    - Recruiting
    - Research Site
  - Essen, Germany, 45355
    - Recruiting
    - Research Site
  - Essen, Germany, 45355
    - Withdrawn
    - Research Site
  - Frankfurt, Germany, 60596
    - Recruiting
    - Research Site
  - Freiburg im Breisgau, Germany, 79106
    - Recruiting
    - Research Site
  - Friedrichsthal, Germany, 66299
    - Suspended
    - Research Site
  - Fulda, Germany, 36037
    - Recruiting
    - Research Site
  - Gelnhausen, Germany, 63571
    - Recruiting
    - Research Site
  - Görlitz, Germany, 02828
    - Recruiting
    - Research Site
  - Hamburg, Germany, 22041
    - Recruiting
    - Research Site
  - Hamburg, Germany, 22459
    - Not yet recruiting
    - Research Site
  - Hamburg, Germany, 22607
    - Recruiting
    - Research Site
  - Hamburg, Germany, 21109
    - Recruiting
    - Research Site
  - Haßloch, Germany, 67454
    - Withdrawn
    - Research Site
  - Heidelberg, Germany, 69120
    - Recruiting
    - Research Site
  - Homburg, Germany, 66424
    - Recruiting
    - Research Site
  - Kaiserslautern, Germany, 67655
    - Recruiting
    - Research Site
  - Kassel, Germany, 34121
    - Recruiting
    - Research Site
  - Langen, Germany, 63225
    - Recruiting
    - Research Site
  - Leipzig, Germany, 04179
    - Recruiting
    - Research Site
  - Leipzig, Germany, 04249
    - Recruiting
    - Research Site
  - Leipzig, Germany, 04347
    - Recruiting
    - Research Site
  - Ludwigshafen, Germany, 67063
    - Recruiting
    - Research Site
  - Ludwigshafen, Germany, 67059
    - Withdrawn
    - Research Site
  - Mannheim, Germany, 68165
    - Withdrawn
    - Research Site
  - Markkleeberg, Germany, 04416
    - Recruiting
    - Research Site
  - Munich, Germany, 80809
    - Withdrawn
    - Research Site
  - Münster, Germany, 48153
    - Withdrawn
    - Research Site
  - Naunhof, Germany, 04683
    - Recruiting
    - Research Site
  - Neuruppin, Germany, 16816
    - Recruiting
    - Research Site
  - Nittendorf, Germany, 93152
    - Recruiting
    - Research Site
  - Obertshausen, Germany, 63179
    - Recruiting
    - Research Site
  - Oldenburg, Germany, 23758
    - Recruiting
    - Research Site
  - Osnabrück, Germany, 49080
    - Recruiting
    - Research Site
  - Papenburg, Germany, 26871
    - Recruiting
    - Research Site
  - Pirna, Germany, 01796
    - Recruiting
    - Research Site
  - Potsdam, Germany, 14473
    - Withdrawn
    - Research Site
  - Ratingen, Germany, 40882
    - Not yet recruiting
    - Research Site
  - Reinfeld (Holstein), Germany, 23858
    - Recruiting
    - Research Site
  - Völklingen, Germany, 66333
    - Withdrawn
    - Research Site
  - Wallerfing, Germany, 94574
    - Recruiting
    - Research Site
  - Wangen, Germany, 88239
    - Withdrawn
    - Research Site
  - Weinheim, Germany, 69469
    - Recruiting
    - Research Site
  - Zwenkau, Germany, 04442
    - Withdrawn
    - Research Site
Greece
- - Athens, Greece, 11528
    - Recruiting
    - Research Site
  - Athens, Greece, 12462
    - Recruiting
    - Research Site
  - Athens, Greece, 11527
    - Recruiting
    - Research Site
  - Athens, Greece, 17562
    - Recruiting
    - Research Site
  - Chania, Greece, 73300
    - Recruiting
    - Research Site
  - Ioannina, Greece, 45500
    - Not yet recruiting
    - Research Site
  - Ioannina, Greece, 45110
    - Recruiting
    - Research Site
  - Larissa, Greece, 41110
    - Recruiting
    - Research Site
  - Piraeus, Greece, 18454
    - Recruiting
    - Research Site
  - Piraeus, Greece, 18536
    - Recruiting
    - Research Site
  - Thessaloniki, Greece, 54642
    - Recruiting
    - Research Site
  - Thessaloniki, Greece, 57001
    - Recruiting
    - Research Site
  - Thessaloniki, Greece, 54636
    - Recruiting
    - Research Site
Hungary
- - Balatonfüred, Hungary, 8230
    - Recruiting
    - Research Site
  - Balatonfüred, Hungary, 8230
    - Withdrawn
    - Research Site
  - Budapest, Hungary, 1033
    - Recruiting
    - Research Site
  - Budapest, Hungary, 1036
    - Recruiting
    - Research Site
  - Budapest, Hungary, 1083
    - Recruiting
    - Research Site
  - Budapest, Hungary, 1122
    - Recruiting
    - Research Site
  - Budapest, Hungary, 1148
    - Recruiting
    - Research Site
  - Budapest, Hungary, 1106
    - Recruiting
    - Research Site
  - Budapest, Hungary, 1102
    - Recruiting
    - Research Site
  - Békéscsaba, Hungary, 5600
    - Recruiting
    - Research Site
  - Debrecen, Hungary, 4032
    - Recruiting
    - Research Site
  - Gyöngyös, Hungary, 3200
    - Withdrawn
    - Research Site
  - Kalocsa, Hungary, 6300
    - Recruiting
    - Research Site
  - Nyíregyháza, Hungary, 4400
    - Withdrawn
    - Research Site
  - Nyíregyháza, Hungary, 4400
    - Recruiting
    - Research Site
  - Nyíregyháza, Hungary, 4405
    - Withdrawn
    - Research Site
  - Nyíregyháza-Sóstóhegy, Hungary, 4481
    - Recruiting
    - Research Site
  - Orosháza, Hungary, 5900
    - Withdrawn
    - Research Site
  - Pécs, Hungary, 7635
    - Recruiting
    - Research Site
  - Pécs, Hungary, 7623
    - Recruiting
    - Research Site
  - Szeged, Hungary, 6724
    - Recruiting
    - Research Site
  - Szigetvár, Hungary, 7900
    - Recruiting
    - Research Site
  - Szolnok, Hungary, 5000
    - Recruiting
    - Research Site
  - Székesfehérvár, Hungary, 8000
    - Recruiting
    - Research Site
India
- - Ahmedabad, India, 380054
    - Recruiting
    - Research Site
  - Ajmer, India, 305001
    - Withdrawn
    - Research Site
  - Bangalore, India, 560069
    - Withdrawn
    - Research Site
  - Belagavi, India, 590010
    - Recruiting
    - Research Site
  - Dehradun, India, 248001
    - Not yet recruiting
    - Research Site
  - Delhi, India, 110062
    - Recruiting
    - Research Site
  - Gurgaon, India, 122001
    - Recruiting
    - Research Site
  - Hyderabad, India, 500082
    - Not yet recruiting
    - Research Site
  - Hyderabad, India, 500035
    - Recruiting
    - Research Site
  - Hyderabad, India, 500 034
    - Recruiting
    - Research Site
  - Hyderabad, India, 500018
    - Withdrawn
    - Research Site
  - Kanpur, India, 208001
    - Recruiting
    - Research Site
  - Karamsad, India, 388345
    - Recruiting
    - Research Site
  - Kolkata, India, 700020
    - Recruiting
    - Research Site
  - Kolkata, India, 700014
    - Recruiting
    - Research Site
  - Lucknow, India, 226010
    - Withdrawn
    - Research Site
  - Nagpur, India, 441108
    - Recruiting
    - Research Site
  - New Delhi, India, 110017
    - Recruiting
    - Research Site
  - New Delhi, India, 110002
    - Recruiting
    - Research Site
  - New Delhi, India, 100049
    - Recruiting
    - Research Site
  - Secunderabad, India, 500003
    - Not yet recruiting
    - Research Site
  - Surat, India, 395001
    - Recruiting
    - Research Site
  - Surat, India, 396007
    - Recruiting
    - Research Site
  - Vijayawada, India, 520 008
    - Recruiting
    - Research Site
Israel
- - Beersheba, Israel, 8410101
    - Recruiting
    - Research Site
  - Be’er Ya‘aqov, Israel, 70300
    - Recruiting
    - Research Site
  - Haifa, Israel, 3109601
    - Recruiting
    - Research Site
  - Herzelia, Israel, 4640200
    - Recruiting
    - Research Site
  - Holon, Israel, 5822012
    - Recruiting
    - Research Site
  - Jerusalem, Israel, 91120
    - Recruiting
    - Research Site
  - Petah Tikva, Israel, 4941492
    - Recruiting
    - Research Site
  - Ramat Gan, Israel, 52621
    - Recruiting
    - Research Site
  - Tel Aviv, Israel, 64239
    - Recruiting
    - Research Site
  - Tel Aviv, Israel, 6423906
    - Recruiting
    - Research Site
  - Tel Aviv, Israel, 61480
    - Recruiting
    - Research Site
Italy
- - Alessandria, Italy, 15100
    - Recruiting
    - Research Site
  - Bari, Italy, 70124
    - Recruiting
    - Research Site
  - Bergamo, Italy, 24127
    - Recruiting
    - Research Site
  - Brescia, Italy, 25123
    - Recruiting
    - Research Site
  - Chiavari, Italy, 16034
    - Recruiting
    - Research Site
  - Cona, Italy, 44124
    - Recruiting
    - Research Site
  - Foggia, Italy, 71100
    - Recruiting
    - Research Site
  - Milan, Italy, 20132
    - Recruiting
    - Research Site
  - Milan, Italy, 20122
    - Recruiting
    - Research Site
  - Milan, Italy, 20138
    - Recruiting
    - Research Site
  - Milan, Italy, 20162
    - Recruiting
    - Research Site
  - Milan, Italy, 20154
    - Recruiting
    - Research Site
  - Mondovì, Italy, 12084
    - Withdrawn
    - Research Site
  - Monza, Italy, 20900
    - Recruiting
    - Research Site
  - Naples, Italy, 80131
    - Recruiting
    - Research Site
  - Novara, Italy, 28100
    - Recruiting
    - Research Site
  - Orbassano, Italy, 10043
    - Recruiting
    - Research Site
  - Palermo, Italy, 90127
    - Recruiting
    - Research Site
  - Pavia, Italy, 27100
    - Recruiting
    - Research Site
  - Potenza, Italy, 85100
    - Recruiting
    - Research Site
  - Roma, Italy, 00133
    - Recruiting
    - Research Site
  - Roma, Italy, 00128
    - Recruiting
    - Research Site
  - Roma, Italy, 161
    - Recruiting
    - Research Site
  - Rome, Italy, 00168
    - Recruiting
    - Research Site
  - Rozzano, Italy, 20089
    - Recruiting
    - Research Site
  - Siena, Italy, 53100
    - Recruiting
    - Research Site
  - Torino, Italy, 10126
    - Recruiting
    - Research Site
  - Udine, Italy, 33100
    - Recruiting
    - Research Site
Japan
- - Amagasaki-shi, Japan, 660-8550
    - Recruiting
    - Research Site
  - Asahikawa-shi, Japan, 070-8610
    - Recruiting
    - Research Site
  - Azumino-shi, Japan, 399-8292
    - Recruiting
    - Research Site
  - Chūōku, Japan, 103-0002
    - Recruiting
    - Research Site
  - Fukui-shi, Japan, 910-8526
    - Recruiting
    - Research Site
  - Hakusan-shi, Japan, 924-8588
    - Recruiting
    - Research Site
  - Himeji, Japan, 670-8560
    - Recruiting
    - Research Site
  - Itabashi-ku, Japan, 173-0015
    - Recruiting
    - Research Site
  - Izumo-shi, Japan, 693-8501
    - Recruiting
    - Research Site
  - Kakegawa-shi, Japan, 436-8555
    - Recruiting
    - Research Site
  - Kamakura-shi, Japan, 247-8533
    - Recruiting
    - Research Site
  - Kanazawa, Japan, 920-8650
    - Recruiting
    - Research Site
  - Kawaguchi-shi, Japan, 332-8558
    - Recruiting
    - Research Site
  - Kishiwada-shi, Japan, 596-0042
    - Recruiting
    - Research Site
  - Kita-ku, Japan, 114-0001
    - Recruiting
    - Research Site
  - Kyoto, Japan, 606-8507
    - Recruiting
    - Research Site
  - Kyoto, Japan, 605-0981
    - Recruiting
    - Research Site
  - Kyoto, Japan, 601-1495
    - Completed
    - Research Site
  - Matsudo-shi, Japan, 271-0077
    - Recruiting
    - Research Site
  - Meguro-ku, Japan, 153-0051
    - Recruiting
    - Research Site
  - Mito, Japan, 311-4198
    - Recruiting
    - Research Site
  - Miyazaki, Japan, 880-0834
    - Recruiting
    - Research Site
  - Nagano, Japan, 399-8695
    - Recruiting
    - Research Site
  - Ogaki-shi, Japan, 503-8502
    - Recruiting
    - Research Site
  - Osaka, Japan, 553-0003
    - Recruiting
    - Research Site
  - Osaka, Japan, 558-8558
    - Recruiting
    - Research Site
  - Osaka, Japan, 530-8480
    - Recruiting
    - Research Site
  - Osaka, Japan, 534-0024
    - Completed
    - Research Site
  - Saitama-shi, Japan, 338-0837
    - Recruiting
    - Research Site
  - Sendai, Japan, 980-8574
    - Recruiting
    - Research Site
  - Sendai, Japan, 983-0039
    - Recruiting
    - Research Site
  - Shizuoka, Japan, 424-0911
    - Recruiting
    - Research Site
  - Suita-shi, Japan, 564-8565
    - Recruiting
    - Research Site
  - Takamatsu, Japan, 760-0017
    - Recruiting
    - Research Site
  - Takatsuki-shi, Japan, 569-1192
    - Recruiting
    - Research Site
  - Toyota-Shi, Japan, 471-8513
    - Recruiting
    - Research Site
  - Tsuchiura-shi, Japan, 300-0028
    - Recruiting
    - Research Site
  - Ueda-shi, Japan, 386-8610
    - Recruiting
    - Research Site
  - Uwajima-shi, Japan, 798-8510
    - Recruiting
    - Research Site
  - Yanagawa-shi, Japan, 832-0077
    - Recruiting
    - Research Site
  - Yokkaichi-shi, Japan, 510-8561
    - Recruiting
    - Research Site
  - Yokohama, Japan, 230-8765
    - Recruiting
    - Research Site
  - tabashi City, Japan, 173-8606
    - Withdrawn
    - Research Site
  - Ōita, Japan, 870-8511
    - Recruiting
    - Research Site
  - Ōmihachiman, Japan, 523-0082
    - Recruiting
    - Research Site
Malaysia
- - Alor Star, Malaysia, 05460
    - Recruiting
    - Research Site
  - Johor Bahru, Malaysia, 80100
    - Recruiting
    - Research Site
  - Kota Samarahan, Malaysia, 94300
    - Recruiting
    - Research Site
  - Kuala Terengganu, Malaysia, 20400
    - Recruiting
    - Research Site
  - Kuantan, Malaysia, 25100
    - Recruiting
    - Research Site
  - Kuching, Malaysia, 93586
    - Recruiting
    - Research Site
  - Malacca, Malaysia, 78300
    - Withdrawn
    - Research Site
  - Rawang, Malaysia, 48050
    - Recruiting
    - Research Site
  - Sarawak Miri, Malaysia, 98000
    - Recruiting
    - Research Site
  - Seri Manjung, Malaysia, 32040
    - Recruiting
    - Research Site
  - Sungai Buloh, Malaysia, 47000
    - Recruiting
    - Research Site
Mexico
- - Acapulco, Mexico, 39670
    - Recruiting
    - Research Site
  - Aguascalientes, Mexico, 20230
    - Recruiting
    - Research Site
  - Cuauhtémoc, Mexico, 6720
    - Recruiting
    - Research Site
  - Cuernavaca, Mexico, 62448
    - Recruiting
    - Research Site
  - Culiacán, Mexico, 80230
    - Recruiting
    - Research Site
  - Culiacán, Mexico, 80200
    - Not yet recruiting
    - Research Site
  - Durango, Mexico, 34000
    - Recruiting
    - Research Site
  - Guadalajara, Mexico, 44670
    - Recruiting
    - Research Site
  - Guadalajara, Mexico, 44670
    - Withdrawn
    - Research Site
  - Mexico City, Mexico, 10700
    - Recruiting
    - Research Site
  - Monterrey, Mexico, 64060
    - Recruiting
    - Research Site
  - Querétaro City, Mexico, 76000
    - Recruiting
    - Research Site
  - San Juan del Río, Mexico, 76800
    - Recruiting
    - Research Site
  - Veracruz, Mexico, 91910
    - Not yet recruiting
    - Research Site
  - Xalapa, Mexico, 91020
    - Not yet recruiting
    - Research Site
  - Xalapa, Mexico, 91193
    - Recruiting
    - Research Site
  - Zapopan, Mexico, 45138
    - Recruiting
    - Research Site
Netherlands
- - 's-Hertogenbosch, Netherlands, 5223 LA
    - Recruiting
    - Research Site
  - Almelo, Netherlands, 7609 PP
    - Recruiting
    - Research Site
  - Amsterdam, Netherlands, 1105 AZ
    - Recruiting
    - Research Site
  - Amsterdam, Netherlands, 1081 GM
    - Recruiting
    - Research Site
  - Born, Netherlands, 6121 XK
    - Recruiting
    - Research Site
  - Deventer, Netherlands, 7416 SE
    - Recruiting
    - Research Site
  - Ede, Netherlands, 6716 RP
    - Recruiting
    - Research Site
  - Enschede, Netherlands, 7512 KZ
    - Recruiting
    - Research Site
  - Haarlem, Netherlands, 2035 RC
    - Recruiting
    - Research Site
  - Harderwijk, Netherlands, 3844
    - Recruiting
    - Research Site
  - Hoogeveen, Netherlands, 7909 AA
    - Recruiting
    - Research Site
  - Nijmegen, Netherlands, 6525 GA
    - Recruiting
    - Research Site
  - Roosendaal, Netherlands, 4708 AE
    - Recruiting
    - Research Site
  - Rotterdam, Netherlands, 3045 PM
    - Recruiting
    - Research Site
  - Rotterdam, Netherlands, 3015GD
    - Recruiting
    - Research Site
  - Venlo, Netherlands, 5912 BL
    - Recruiting
    - Research Site
  - Zwolle, Netherlands, 8025AZ
    - Recruiting
    - Research Site
Peru
- - Bellavista, Peru, CALLAO 2
    - Not yet recruiting
    - Research Site
  - Callao, Peru, Bellavista
    - Not yet recruiting
    - Research Site
  - Chorrillos, Peru, Lima 9
    - Recruiting
    - Research Site
  - Cusco, Peru, CUSCO 01
    - Not yet recruiting
    - Research Site
  - Lima, Peru, LIMA 11
    - Not yet recruiting
    - Research Site
  - Lima, Peru, 15036
    - Not yet recruiting
    - Research Site
  - Lima, Peru, 15088
    - Recruiting
    - Research Site
  - Lima, Peru, LIMA 01
    - Not yet recruiting
    - Research Site
  - Lima, Peru, 15046
    - Recruiting
    - Research Site
  - Lima, Peru, 14
    - Recruiting
    - Research Site
  - Lima, Peru, 15072
    - Not yet recruiting
    - Research Site
  - Lima, Peru, 15102
    - Not yet recruiting
    - Research Site
  - Lima, Peru, L18
    - Withdrawn
    - Research Site
  - Lima, Peru, 15131
    - Withdrawn
    - Research Site
  - Lima, Peru, LIMA 41
    - Recruiting
    - Research Site
  - Lima, Peru, 15074
    - Withdrawn
    - Research Site
  - Piura, Peru, 20001
    - Not yet recruiting
    - Research Site
Philippines
- - Angeles City, Philippines, 2009
    - Recruiting
    - Research Site
  - Cebu, Philippines, 6000
    - Recruiting
    - Research Site
  - Davao City, Philippines, 8000
    - Recruiting
    - Research Site
  - Davao City, Philippines, PH-8000
    - Recruiting
    - Research Site
  - Fuente Osmena Cebu City, Philippines, 6000
    - Recruiting
    - Research Site
  - Iloilo City, Philippines, 5000
    - Recruiting
    - Research Site
  - Las Piñas, Philippines, 1742
    - Recruiting
    - Research Site
  - Lipa City, Philippines, 4217
    - Recruiting
    - Research Site
  - Manadaluyong City, Philippines, 1552
    - Suspended
    - Research Site
  - Puerto Princesa City, Philippines, 5300
    - Recruiting
    - Research Site
  - Quezon City, Philippines, 1100
    - Recruiting
    - Research Site
  - Roxas City, Philippines, 5800
    - Recruiting
    - Research Site
Poland
- - Bialystok, Poland, 15-481
    - Recruiting
    - Research Site
  - Biała Podlaska, Poland, 21-500
    - Recruiting
    - Research Site
  - Bydgoszcz, Poland, 85-095
    - Withdrawn
    - Research Site
  - Chojnice, Poland, 89-600
    - Recruiting
    - Research Site
  - Chojnice, Poland, 89-600
    - Withdrawn
    - Research Site
  - Chrzanów, Poland, 32-500
    - Recruiting
    - Research Site
  - Częstochowa, Poland, 42-202
    - Recruiting
    - Research Site
  - Gdansk, Poland, 80-214
    - Recruiting
    - Research Site
  - Gdansk, Poland, 80-286
    - Withdrawn
    - Research Site
  - Gdynia, Poland, 81-157
    - Recruiting
    - Research Site
  - Gdynia, Poland, 81-537
    - Recruiting
    - Research Site
  - Jasło, Poland, 38-200
    - Recruiting
    - Research Site
  - Katowice, Poland, 40-081
    - Recruiting
    - Research Site
  - Katowice, Poland, 40-040
    - Recruiting
    - Research Site
  - Katowice, Poland, 40-752
    - Withdrawn
    - Research Site
  - Katowice, Poland, 40-600
    - Recruiting
    - Research Site
  - Katowice, Poland, 40-156
    - Recruiting
    - Research Site
  - Katowice, Poland, 40-748
    - Recruiting
    - Research Site
  - Krakow, Poland, 31-121
    - Recruiting
    - Research Site
  - Krakow, Poland, 31-322
    - Recruiting
    - Research Site
  - Lodz, Poland, 90-302
    - Recruiting
    - Research Site
  - Lodz, Poland, 90-549
    - Withdrawn
    - Research Site
  - Lublin, Poland, 20-718
    - Recruiting
    - Research Site
  - Lublin, Poland, 20-857
    - Recruiting
    - Research Site
  - Lublin, Poland, 20-068
    - Recruiting
    - Research Site
  - Lublin, Poland, 20-518
    - Not yet recruiting
    - Research Site
  - Myszków, Poland, 42-300
    - Recruiting
    - Research Site
  - Olsztyn, Poland, 10-165
    - Recruiting
    - Research Site
  - Ostrów Mazowiecka, Poland, 07-300
    - Recruiting
    - Research Site
  - Piekary Śląskie, Poland, 41-940
    - Recruiting
    - Research Site
  - Poznan, Poland, 60-111
    - Recruiting
    - Research Site
  - Poznan, Poland, 60-309
    - Recruiting
    - Research Site
  - Poznan, Poland, 60-702
    - Recruiting
    - Research Site
  - Poznan, Poland, 61-848
    - Recruiting
    - Research Site
  - Przemyśl, Poland, 37-700
    - Recruiting
    - Research Site
  - Płock, Poland, 09-407
    - Recruiting
    - Research Site
  - Radzionków, Poland, 41-922
    - Recruiting
    - Research Site
  - Rzeszów, Poland, 35-205
    - Recruiting
    - Research Site
  - Skórzewo, Poland, 60-185
    - Recruiting
    - Research Site
  - Szczecin, Poland, 71-434
    - Withdrawn
    - Research Site
  - Szczecin, Poland, 71-526
    - Recruiting
    - Research Site
  - Tarnów, Poland, 33-100
    - Recruiting
    - Research Site
  - Torun, Poland, 87-100
    - Recruiting
    - Research Site
  - Warsaw, Poland, 02-507
    - Recruiting
    - Research Site
  - Warsaw, Poland, 04-501
    - Recruiting
    - Research Site
  - Warsaw, Poland, 00-124
    - Recruiting
    - Research Site
  - Warsaw, Poland, 02-758
    - Recruiting
    - Research Site
  - Warsaw, Poland, 02-798
    - Recruiting
    - Research Site
  - Warsaw, Poland, 04-628
    - Recruiting
    - Research Site
  - Warsaw, Poland, 00-872
    - Recruiting
    - Research Site
  - Wroclaw, Poland, 50-981
    - Recruiting
    - Research Site
  - Zabrze, Poland, 41-800
    - Withdrawn
    - Research Site
Romania
- - Bacau, Romania, 600274
    - Recruiting
    - Research Site
  - Baia Mare, Romania, 430222
    - Recruiting
    - Research Site
  - Baia Mare, Romania, 430124
    - Recruiting
    - Research Site
  - Brasov, Romania, 500102
    - Recruiting
    - Research Site
  - Bucharest, Romania, 050098
    - Recruiting
    - Research Site
  - Bucharest, Romania, 020475
    - Recruiting
    - Research Site
  - Bucharest, Romania, 010507
    - Recruiting
    - Research Site
  - Bucharest, Romania, 010825
    - Recruiting
    - Research Site
  - Bucharest, Romania, 031818
    - Recruiting
    - Research Site
  - Bucharest, Romania, 012296
    - Recruiting
    - Research Site
  - Craiova, Romania, 200642
    - Recruiting
    - Research Site
  - Iași, Romania, 700515
    - Recruiting
    - Research Site
  - Ploieşti, Romania, 100179
    - Recruiting
    - Research Site
  - Satu Mare, Romania, 440055
    - Recruiting
    - Research Site
  - Târgu Mureş, Romania, 540136
    - Recruiting
    - Research Site
Slovakia
- - Bratislava, Slovakia, 831 03
    - Recruiting
    - Research Site
  - Bratislava, Slovakia, 83106
    - Recruiting
    - Research Site
  - Bratislava, Slovakia, 83101
    - Recruiting
    - Research Site
  - Brezno, Slovakia, 977 01
    - Recruiting
    - Research Site
  - Handlová, Slovakia, 972 51
    - Recruiting
    - Research Site
  - Košice, Slovakia, 04001
    - Recruiting
    - Research Site
  - Košice, Slovakia, 04022
    - Recruiting
    - Research Site
  - Lučenec, Slovakia, 984 01
    - Recruiting
    - Research Site
  - Malacky, Slovakia, 901 22
    - Recruiting
    - Research Site
  - Námestovo, Slovakia, 029 01
    - Recruiting
    - Research Site
  - Prešov, Slovakia, 080 01
    - Recruiting
    - Research Site
  - Prievidza, Slovakia, 97101
    - Recruiting
    - Research Site
  - Rimavská Sobota, Slovakia, 979 01
    - Recruiting
    - Research Site
  - Rožňava, Slovakia, 048 01
    - Withdrawn
    - Research Site
  - Sabinov, Slovakia, 08301
    - Withdrawn
    - Research Site
  - Svidník, Slovakia, 08901
    - Recruiting
    - Research Site
  - Ľubochňa, Slovakia, 03491
    - Recruiting
    - Research Site
South Africa
- - Bellville, South Africa, 7530
    - Recruiting
    - Research Site
  - Benoni, South Africa, 1501
    - Recruiting
    - Research Site
  - Brackenfell, South Africa, 7560
    - Recruiting
    - Research Site
  - Cape Town, South Africa, 7500
    - Recruiting
    - Research Site
  - Cape Town, South Africa, 1730
    - Withdrawn
    - Research Site
  - Centurion, South Africa, 0157
    - Recruiting
    - Research Site
  - Claremont, South Africa, 7708
    - Recruiting
    - Research Site
  - Diepkloof, Soweto, South Africa, 2013
    - Recruiting
    - Research Site
  - Durban, South Africa, 4001
    - Recruiting
    - Research Site
  - Durban, South Africa, 4052
    - Recruiting
    - Research Site
  - East London, South Africa, 5219
    - Recruiting
    - Research Site
  - Johannesburg, South Africa, 1827
    - Recruiting
    - Research Site
  - Lenasia, South Africa, 1827
    - Recruiting
    - Research Site
  - Midrand, South Africa, 1685
    - Recruiting
    - Research Site
  - Paarl, South Africa, 7646
    - Recruiting
    - Research Site
  - Pretoria, South Africa, 0186
    - Recruiting
    - Research Site
  - Pretoria, South Africa, 0184
    - Withdrawn
    - Research Site
  - Somerset West, South Africa, 7130
    - Recruiting
    - Research Site
  - Wentworth, South Africa, 4032
    - Recruiting
    - Research Site
  - Worcester, South Africa, 6850
    - Recruiting
    - Research Site
  - eMkhomazi, South Africa, 4170
    - Recruiting
    - Research Site
South Korea
- - Bucheon-si, South Korea, 14754
    - Recruiting
    - Research Site
  - Cheongju-si, South Korea, 28644
    - Recruiting
    - Research Site
  - Daegu, South Korea, 42601
    - Recruiting
    - Research Site
  - Seongnam-si, South Korea, 13620
    - Recruiting
    - Research Site
  - Seoul, South Korea, 03080
    - Recruiting
    - Research Site
  - Seoul, South Korea, 5505
    - Recruiting
    - Research Site
  - Seoul, South Korea, 06591
    - Recruiting
    - Research Site
  - Seoul, South Korea, 08308
    - Recruiting
    - Research Site
  - Seoul, South Korea, 02841
    - Recruiting
    - Research Site
  - Seoul, South Korea, 135-710
    - Recruiting
    - Research Site
  - Seoul, South Korea, 120-752
    - Recruiting
    - Research Site
  - Suwon, South Korea, 16499
    - Recruiting
    - Research Site
  - Wŏnju, South Korea, 26426
    - Recruiting
    - Research Site
  - Yangsan, South Korea, 50612
    - Recruiting
    - Research Site
Spain
- - A Coruña, Spain, 15006
    - Recruiting
    - Research Site
  - Barcelona, Spain, 08041
    - Recruiting
    - Research Site
  - Barcelona, Spain, 08036
    - Recruiting
    - Research Site
  - Barcelona, Spain, 08003
    - Recruiting
    - Research Site
  - Córdoba, Spain, 14004
    - Recruiting
    - Research Site
  - Córdoba, Spain, 14940
    - Recruiting
    - Research Site
  - L'Hospitalet de Llobregat, Spain, 08907
    - Recruiting
    - Research Site
  - Madrid, Spain, 28040
    - Recruiting
    - Research Site
  - Málaga, Spain, 29010
    - Recruiting
    - Research Site
  - Sant Joan Despí, Spain, 08970
    - Recruiting
    - Research Site
  - Santiago(A Coruña), Spain, 15706
    - Recruiting
    - Research Site
  - Seville, Spain, 41004
    - Recruiting
    - Research Site
  - Seville, Spain, 41071
    - Recruiting
    - Research Site
  - Valencia, Spain, 46010
    - Recruiting
    - Research Site
  - Vigo, Spain, 36312
    - Recruiting
    - Research Site
Sweden
- - Gothenburg, Sweden, 413 46
    - Recruiting
    - Research Site
  - Helsingborg, Sweden, 252 21
    - Recruiting
    - Research Site
  - Huddinge, Sweden, 141 86
    - Recruiting
    - Research Site
  - Lund, Sweden, 222 42
    - Recruiting
    - Research Site
  - Lund, Sweden, 222 21
    - Recruiting
    - Research Site
  - Mölndal, Sweden, 431 80
    - Recruiting
    - Research Site
  - Norrköping, Sweden, 603 79
    - Recruiting
    - Research Site
  - Stockholm, Sweden, 118 83
    - Recruiting
    - Research Site
  - Stockholm, Sweden, 113 61
    - Recruiting
    - Research Site
  - Stockholm, Sweden, 117 27
    - Recruiting
    - Research Site
  - Uppsala, Sweden, 751 85
    - Recruiting
    - Research Site
  - Uppsala, Sweden, 75233
    - Recruiting
    - Research Site
Taiwan
- - Changhua, Taiwan, 500
    - Recruiting
    - Research Site
  - Hsinchu, Taiwan, 300
    - Recruiting
    - Research Site
  - Hualien City, Taiwan, 970473
    - Recruiting
    - Research Site
  - Kaohsiung City, Taiwan, 80756
    - Recruiting
    - Research Site
  - New Taipei City, Taiwan, 231
    - Recruiting
    - Research Site
  - Taichung, Taiwan, 40705
    - Recruiting
    - Research Site
  - Taichung, Taiwan, 404
    - Recruiting
    - Research Site
  - Taichung, Taiwan, 40201
    - Recruiting
    - Research Site
  - Taichung, Taiwan, 433004
    - Recruiting
    - Research Site
  - Tainan, Taiwan, 710
    - Recruiting
    - Research Site
  - Taipei, Taiwan, 10002
    - Recruiting
    - Research Site
  - Taipei, Taiwan, 11490
    - Recruiting
    - Research Site
  - Taipei, Taiwan, 11217
    - Recruiting
    - Research Site
  - Taipei, Taiwan, 10449
    - Recruiting
    - Research Site
  - Taipei, Taiwan, 11101
    - Recruiting
    - Research Site
  - Taipei, Taiwan, 116
    - Recruiting
    - Research Site
  - Taipei, Taiwan, 110
    - Recruiting
    - Research Site
  - Taoyuan, Taiwan, 333
    - Recruiting
    - Research Site
Thailand
- - Bangkok, Thailand, 10330
    - Recruiting
    - Research Site
  - Bangkok, Thailand, 10700
    - Recruiting
    - Research Site
  - Banphaeo, Thailand, 74120
    - Recruiting
    - Research Site
  - Bansuan, Muang, Chonburi, Thailand, 20000
    - Recruiting
    - Research Site
  - Chiang Mai, Thailand, 50200
    - Recruiting
    - Research Site
  - Dusit, Thailand, 10300
    - Recruiting
    - Research Site
  - Hat Yai, Thailand, 90110
    - Recruiting
    - Research Site
  - Khlong Luang, Thailand, 12120
    - Recruiting
    - Research Site
  - Khon Kaen, Thailand, 40002
    - Recruiting
    - Research Site
  - Muang, Thailand, 22000
    - Recruiting
    - Research Site
  - Naimuang, Thailand, 30000
    - Recruiting
    - Research Site
  - Ubonratchathani, Thailand, 34000
    - Recruiting
    - Research Site
Turkey (Türkiye)
- - Adana, Turkey (Türkiye), 01130
    - Recruiting
    - Research Site
  - Afyonkarahisar, Turkey (Türkiye), 03030
    - Recruiting
    - Research Site
  - Ankara, Turkey (Türkiye), 06530
    - Recruiting
    - Research Site
  - Antalya, Turkey (Türkiye), 07059
    - Recruiting
    - Research Site
  - Eskişehir, Turkey (Türkiye), 26040
    - Recruiting
    - Research Site
  - Istanbul, Turkey (Türkiye), 34303
    - Recruiting
    - Research Site
  - Istanbul, Turkey (Türkiye), 34899
    - Recruiting
    - Research Site
  - Izmir, Turkey (Türkiye), 35340
    - Recruiting
    - Research Site
  - Kahramanmaraş, Turkey (Türkiye), 46100
    - Recruiting
    - Research Site
  - Kocaeli, Turkey (Türkiye), 41001
    - Recruiting
    - Research Site
  - Kütahya, Turkey (Türkiye), 43100
    - Recruiting
    - Research Site
  - Malatya, Turkey (Türkiye), 44280
    - Recruiting
    - Research Site
  - Samsun, Turkey (Türkiye), 55270
    - Recruiting
    - Research Site
  - Sivas, Turkey (Türkiye), 58140
    - Recruiting
    - Research Site
Ukraine
- - Chernivtsі, Ukraine, 58002
    - Recruiting
    - Research Site
  - Ivano-Frankivsk, Ukraine, 76018
    - Recruiting
    - Research Site
  - Kyiv, Ukraine, 04050
    - Recruiting
    - Research Site
  - Kyiv, Ukraine, 01601
    - Recruiting
    - Research Site
  - Kyiv, Ukraine, 02081
    - Recruiting
    - Research Site
  - Kyiv, Ukraine, 03037
    - Recruiting
    - Research Site
  - Kyiv, Ukraine, 03680
    - Recruiting
    - Research Site
  - Kyiv, Ukraine, 03151
    - Recruiting
    - Research Site
  - Ternopil, Ukraine, 46002
    - Recruiting
    - Research Site
  - Ternopil, Ukraine, 46000
    - Withdrawn
    - Research Site
  - Uzhhorod, Ukraine, 88014
    - Recruiting
    - Research Site
  - Vinnytsia, Ukraine, 21001
    - Recruiting
    - Research Site
  - Vinnytsia, Ukraine, 21029
    - Recruiting
    - Research Site
  - Zhytomyr, Ukraine, 100002
    - Recruiting
    - Research Site
United Kingdom
- - Aberdeen, United Kingdom, AB25 2ZN
    - Recruiting
    - Research Site
  - Chesterfield, United Kingdom, S40 4AA
    - Recruiting
    - Research Site
  - Dundee, United Kingdom, DD1 9SY
    - Recruiting
    - Research Site
  - Gatley, United Kingdom, SK8 4NQ
    - Withdrawn
    - Research Site
  - Glasgow, United Kingdom, G51 4TF
    - Recruiting
    - Research Site
  - Glasgow, United Kingdom, G31 2ER
    - Recruiting
    - Research Site
  - London, United Kingdom, E11BB
    - Recruiting
    - Research Site
  - Norwich, United Kingdom, NR128DU
    - Recruiting
    - Research Site
  - Penzance, United Kingdom, TR18 3DX
    - Recruiting
    - Research Site
  - Redruth, United Kingdom, TR16 4ET
    - Withdrawn
    - Research Site
  - Sandbach, United Kingdom, CW11 1EQ
    - Recruiting
    - Research Site
  - Southampton, United Kingdom, SO303JB
    - Withdrawn
    - Research Site
  - Stockton-on-Tees, United Kingdom, TS19 8PE
    - Withdrawn
    - Research Site
  - Swansea, United Kingdom, SA6 6NL
    - Recruiting
    - Research Site
  - Weston-super-Mare, United Kingdom, BS24 7PR
    - Recruiting
    - Research Site
  - Wolverhampton, United Kingdom, WV10 0QP
    - Recruiting
    - Research Site
  - Woodbridge, United Kingdom, IP136TH
    - Recruiting
    - Research Site
  - Yate, United Kingdom, BS37 4AX
    - Recruiting
    - Research Site
United States
- Alabama
  - Birmingham, Alabama, United States, 35205
    - Recruiting
    - Research Site
  - Centreville, Alabama, United States, 35042
    - Recruiting
    - Research Site
  - Fairhope, Alabama, United States, 36532
    - Recruiting
    - Research Site
  - Huntsville, Alabama, United States, 35801
    - Recruiting
    - Research Site
  - Mobile, Alabama, United States, 36608
    - Recruiting
    - Research Site
  - Sheffield, Alabama, United States, 35660
    - Not yet recruiting
    - Research Site
  - Vestavia Hills, Alabama, United States, 35216
    - Recruiting
    - Research Site
- Alaska
  - Anchorage, Alaska, United States, 99508
    - Not yet recruiting
    - Research Site
- Arizona
  - Gilbert, Arizona, United States, 85296
    - Recruiting
    - Research Site
  - Glendale, Arizona, United States, 85308
    - Recruiting
    - Research Site
  - Tempe, Arizona, United States, 85283
    - Recruiting
    - Research Site
  - Tucson, Arizona, United States, 85712
    - Recruiting
    - Research Site
- California
  - Dublin, California, United States, 94568
    - Withdrawn
    - Research Site
  - Huntington Beach, California, United States, 92648
    - Recruiting
    - Research Site
  - Inglewood, California, United States, 90301
    - Recruiting
    - Research Site
  - La Jolla, California, United States, 92037
    - Recruiting
    - Research Site
  - Lakewood, California, United States, 90805
    - Withdrawn
    - Research Site
  - Lincoln, California, United States, 95648
    - Recruiting
    - Research Site
  - Loma Linda, California, United States, 92357
    - Recruiting
    - Research Site
  - Los Angeles, California, United States, 90073
    - Not yet recruiting
    - Research Site
  - Los Angeles, California, United States, 90035
    - Recruiting
    - Research Site
  - Sacramento, California, United States, 95841
    - Recruiting
    - Research Site
  - San Diego, California, United States, 92120
    - Recruiting
    - Research Site
  - San Dimas, California, United States, 91773
    - Recruiting
    - Research Site
  - San Francisco, California, United States, 94115
    - Not yet recruiting
    - Research Site
  - San Francisco, California, United States, 94121
    - Not yet recruiting
    - Research Site
  - Santa Maria, California, United States, 93454
    - Recruiting
    - Research Site
  - Sherman Oaks, California, United States, 91403
    - Suspended
    - Research Site
  - Thousand Oaks, California, United States, 91360
    - Recruiting
    - Research Site
- Colorado
  - Aurora, Colorado, United States, 80012
    - Recruiting
    - Research Site
  - Englewood, Colorado, United States, 80110
    - Recruiting
    - Research Site
- Connecticut
  - Bridgeport, Connecticut, United States, 06606
    - Recruiting
    - Research Site
  - Stamford, Connecticut, United States, 06905
    - Recruiting
    - Research Site
  - Waterbury, Connecticut, United States, 06708
    - Recruiting
    - Research Site
- Florida
  - Crystal River, Florida, United States, 34429
    - Recruiting
    - Research Site
  - Fort Lauderdale, Florida, United States, 33316
    - Recruiting
    - Research Site
  - Fort Myers, Florida, United States, 33912
    - Recruiting
    - Research Site
  - Gainesville, Florida, United States, 32608
    - Withdrawn
    - Research Site
  - Hialeah, Florida, United States, 33012
    - Recruiting
    - Research Site
  - Jacksonville, Florida, United States, 32216
    - Recruiting
    - Research Site
  - Lakeland, Florida, United States, 33813
    - Recruiting
    - Research Site
  - Miami, Florida, United States, 33125
    - Not yet recruiting
    - Research Site
  - Miami, Florida, United States, 33173
    - Not yet recruiting
    - Research Site
  - Miami, Florida, United States, 33135
    - Suspended
    - Research Site
  - Ocoee, Florida, United States, 34761
    - Recruiting
    - Research Site
  - Orlando, Florida, United States, 32822
    - Recruiting
    - Research Site
  - Palmetto Bay, Florida, United States, 33157
    - Recruiting
    - Research Site
  - Saint Augustine, Florida, United States, 32086
    - Recruiting
    - Research Site
- Georgia
  - Albany, Georgia, United States, 31707
    - Recruiting
    - Research Site
  - Atlanta, Georgia, United States, 30303
    - Recruiting
    - Research Site
  - Canton, Georgia, United States, 30114
    - Recruiting
    - Research Site
  - Columbus, Georgia, United States, 31904
    - Recruiting
    - Research Site
  - Cordele, Georgia, United States, 31015
    - Recruiting
    - Research Site
  - Suwanee, Georgia, United States, 30024
    - Recruiting
    - Research Site
  - Tucker, Georgia, United States, 30084
    - Not yet recruiting
    - Research Site
  - Woodstock, Georgia, United States, 30189
    - Recruiting
    - Research Site
- Idaho
  - Idaho Falls, Idaho, United States, 83404
    - Recruiting
    - Research Site
- Illinois
  - Champaign, Illinois, United States, 61822
    - Recruiting
    - Research Site
  - Chicago, Illinois, United States, 60621
    - Recruiting
    - Research Site
  - Chicago, Illinois, United States, 60616
    - Recruiting
    - Research Site
  - Chicago, Illinois, United States, 60631
    - Recruiting
    - Research Site
  - Gurnee, Illinois, United States, 60031
    - Recruiting
    - Research Site
  - Island Lake, Illinois, United States, 60042
    - Recruiting
    - Research Site
  - Park Ridge, Illinois, United States, 60068
    - Recruiting
    - Research Site
- Indiana
  - Indianapolis, Indiana, United States, 46202
    - Recruiting
    - Research Site
  - Munster, Indiana, United States, 46321
    - Recruiting
    - Research Site
  - Richmond, Indiana, United States, 47374
    - Recruiting
    - Research Site
  - South Bend, Indiana, United States, 46617
    - Recruiting
    - Research Site
- Kansas
  - El Dorado, Kansas, United States, 67042
    - Recruiting
    - Research Site
  - Lenexa, Kansas, United States, 66219
    - Recruiting
    - Research Site
  - Newton, Kansas, United States, 67114
    - Recruiting
    - Research Site
  - Wichita, Kansas, United States, 67218
    - Withdrawn
    - Research Site
- Kentucky
  - Lexington, Kentucky, United States, 40509
    - Recruiting
    - Research Site
  - Owensboro, Kentucky, United States, 42301
    - Recruiting
    - Research Site
  - Paducah, Kentucky, United States, 42001
    - Recruiting
    - Research Site
- Louisiana
  - Alexandria, Louisiana, United States, 71303
    - Recruiting
    - Research Site
  - Bossier City, Louisiana, United States, 71111
    - Not yet recruiting
    - Research Site
  - Shreveport, Louisiana, United States, 71101
    - Recruiting
    - Research Site
- Maryland
  - Baltimore, Maryland, United States, 21229
    - Recruiting
    - Research Site
  - Beltsville, Maryland, United States, 20705
    - Recruiting
    - Research Site
  - Lutherville-Timonium, Maryland, United States, 21093
    - Recruiting
    - Research Site
  - Potomac, Maryland, United States, 20854
    - Recruiting
    - Research Site
- Massachusetts
  - Boston, Massachusetts, United States, 02115
    - Recruiting
    - Research Site
  - New Bedford, Massachusetts, United States, 02740
    - Recruiting
    - Research Site
  - Roslindale, Massachusetts, United States, 02131
    - Recruiting
    - Research Site
- Michigan
  - Farmington Hills, Michigan, United States, 48336
    - Recruiting
    - Research Site
  - Flint, Michigan, United States, 48532
    - Recruiting
    - Research Site
  - Troy, Michigan, United States, 48098
    - Recruiting
    - Research Site
  - Ypsilanti, Michigan, United States, 48197
    - Not yet recruiting
    - Research Site
- Minnesota
  - Mankato, Minnesota, United States, 56001
    - Recruiting
    - Research Site
  - Minneapolis, Minnesota, United States, 55417
    - Recruiting
    - Research Site
- Missouri
  - Columbia, Missouri, United States, 65201
    - Recruiting
    - Research Site
  - Kansas City, Missouri, United States, 64111
    - Recruiting
    - Research Site
  - Kansas City, Missouri, United States, 64151
    - Recruiting
    - Research Site
  - St Louis, Missouri, United States, 63136
    - Recruiting
    - Research Site
- Montana
  - Kalispell, Montana, United States, 59901
    - Withdrawn
    - Research Site
  - Missoula, Montana, United States, 59804
    - Recruiting
    - Research Site
- Nebraska
  - Norfolk, Nebraska, United States, 68701
    - Recruiting
    - Research Site
  - Omaha, Nebraska, United States, 68134
    - Recruiting
    - Research Site
- Nevada
  - Carson City, Nevada, United States, 89706
    - Recruiting
    - Research Site
- New Hampshire
  - Portsmouth, New Hampshire, United States, 03801
    - Withdrawn
    - Research Site
- New Jersey
  - Eatontown, New Jersey, United States, 07724
    - Not yet recruiting
    - Research Site
  - Pennington, New Jersey, United States, 08534
    - Recruiting
    - Research Site
  - Somerset, New Jersey, United States, 08873
    - Recruiting
    - Research Site
- New Mexico
  - Albuquerque, New Mexico, United States, 87102
    - Recruiting
    - Research Site
  - Albuquerque, New Mexico, United States, 87108
    - Recruiting
    - Research Site
- New York
  - Albany, New York, United States, 12208
    - Recruiting
    - Research Site
  - Albany, New York, United States, 12211
    - Not yet recruiting
    - Research Site
  - Brooklyn, New York, United States, 11201
    - Recruiting
    - Research Site
  - Brooklyn, New York, United States, 11220
    - Recruiting
    - Research Site
  - Massapequa, New York, United States, 11758
    - Recruiting
    - Research Site
  - New York, New York, United States, 10029
    - Not yet recruiting
    - Research Site
  - Queens Village, New York, United States, 11428
    - Recruiting
    - Research Site
- North Carolina
  - Charlotte, North Carolina, United States, 28287
    - Recruiting
    - Research Site
  - Durham, North Carolina, United States, 27701
    - Recruiting
    - Research Site
  - Fayetteville, North Carolina, United States, 28304
    - Recruiting
    - Research Site
  - Kernersville, North Carolina, United States, 27284
    - Withdrawn
    - Research Site
  - Monroe, North Carolina, United States, 28112
    - Recruiting
    - Research Site
  - New Bern, North Carolina, United States, 28562
    - Recruiting
    - Research Site
  - Raleigh, North Carolina, United States, 27607
    - Recruiting
    - Research Site
  - Rocky Mount, North Carolina, United States, 27804
    - Recruiting
    - Research Site
- North Dakota
  - Fargo, North Dakota, United States, 58104
    - Recruiting
    - Research Site
- Ohio
  - Beavercreek, Ohio, United States, 45431
    - Recruiting
    - Research Site
  - Canton, Ohio, United States, 44718
    - Recruiting
    - Research Site
  - Cincinnati, Ohio, United States, 45219
    - Recruiting
    - Research Site
  - Cincinnati, Ohio, United States, 45220
    - Recruiting
    - Research Site
  - Columbus, Ohio, United States, 43215
    - Recruiting
    - Research Site
  - Columbus, Ohio, United States, 43228
    - Not yet recruiting
    - Research Site
  - Dayton, Ohio, United States, 45424
    - Not yet recruiting
    - Research Site
  - Maumee, Ohio, United States, 43537
    - Recruiting
    - Research Site
  - Toledo, Ohio, United States, 43606
    - Not yet recruiting
    - Research Site
- Oklahoma
  - Norman, Oklahoma, United States, 73069
    - Withdrawn
    - Research Site
  - Oklahoma City, Oklahoma, United States, 73120
    - Recruiting
    - Research Site
  - Oklahoma City, Oklahoma, United States, 73111
    - Recruiting
    - Research Site
- Oregon
  - Medford, Oregon, United States, 97504
    - Withdrawn
    - Research Site
- Pennsylvania
  - Camp Hill, Pennsylvania, United States, 17011
    - Recruiting
    - Research Site
  - Horsham, Pennsylvania, United States, 19044
    - Recruiting
    - Research Site
  - Philadelphia, Pennsylvania, United States, 19114
    - Recruiting
    - Research Site
  - Scottdale, Pennsylvania, United States, 15683
    - Recruiting
    - Research Site
  - Smithfield, Pennsylvania, United States, 15478
    - Recruiting
    - Research Site
  - West Chester, Pennsylvania, United States, 19380
    - Not yet recruiting
    - Research Site
- South Carolina
  - Columbia, South Carolina, United States, 29209
    - Not yet recruiting
    - Research Site
  - Fort Mill, South Carolina, United States, 29715
    - Recruiting
    - Research Site
  - Greenville, South Carolina, United States, 29615
    - Withdrawn
    - Research Site
  - Mt. Pleasant, South Carolina, United States, 29464
    - Recruiting
    - Research Site
  - North Charleston, South Carolina, United States, 29405
    - Recruiting
    - Research Site
  - Spartanburg, South Carolina, United States, 29301
    - Recruiting
    - Research Site
- Tennessee
  - Cleveland, Tennessee, United States, 37312
    - Recruiting
    - Research Site
  - Morristown, Tennessee, United States, 37813
    - Recruiting
    - Research Site
  - Nashville, Tennessee, United States, 37203
    - Recruiting
    - Research Site
- Texas
  - Abilene, Texas, United States, 79606
    - Suspended
    - Research Site
  - Austin, Texas, United States, 78704
    - Recruiting
    - Research Site
  - Beaumont, Texas, United States, 77702
    - Recruiting
    - Research Site
  - Brownsville, Texas, United States, 78526
    - Not yet recruiting
    - Research Site
  - Dallas, Texas, United States, 75390-9015
    - Recruiting
    - Research Site
  - Duncanville, Texas, United States, 75137
    - Recruiting
    - Research Site
  - El Paso, Texas, United States, 79935
    - Not yet recruiting
    - Research Site
  - El Paso, Texas, United States, 79905
    - Suspended
    - Research Site
  - Houston, Texas, United States, 77089
    - Recruiting
    - Research Site
  - Houston, Texas, United States, 77084
    - Recruiting
    - Research Site
  - Lewisville, Texas, United States, 75067
    - Withdrawn
    - Research Site
  - Mansfield, Texas, United States, 76063
    - Withdrawn
    - Research Site
  - McAllen, Texas, United States, 78503
    - Recruiting
    - Research Site
  - McAllen, Texas, United States, 78501
    - Recruiting
    - Research Site
  - Mesquite, Texas, United States, 75149
    - Recruiting
    - Research Site
  - Paris, Texas, United States, 75462
    - Recruiting
    - Research Site
  - Pearland, Texas, United States, 77584
    - Suspended
    - Research Site
  - San Antonio, Texas, United States, 78231
    - Not yet recruiting
    - Research Site
  - San Antonio, Texas, United States, 78257
    - Recruiting
    - Research Site
  - Stephenville, Texas, United States, 76401
    - Recruiting
    - Research Site
  - Sugar Land, Texas, United States, 77479
    - Recruiting
    - Research Site
  - Tomball, Texas, United States, 77375
    - Recruiting
    - Research Site
  - Weslaco, Texas, United States, 78596
    - Recruiting
    - Research Site
  - Woodway, Texas, United States, 76712
    - Recruiting
    - Research Site
- Utah
  - Clearfield, Utah, United States, 84015
    - Recruiting
    - Research Site
  - Ogden, Utah, United States, 84405
    - Recruiting
    - Research Site
- Vermont
  - Burlington, Vermont, United States, 05401
    - Not yet recruiting
    - Research Site
- Virginia
  - Burke, Virginia, United States, 22015
    - Recruiting
    - Research Site
  - Charlottesville, Virginia, United States, 22911
    - Recruiting
    - Research Site
  - Fairfax, Virginia, United States, 22033
    - Not yet recruiting
    - Research Site
  - Falls Church, Virginia, United States, 22042
    - Recruiting
    - Research Site
  - Manassas, Virginia, United States, 20110
    - Not yet recruiting
    - Research Site
  - Midlothian, Virginia, United States, 23112
    - Recruiting
    - Research Site
  - Norfolk, Virginia, United States, 23502
    - Recruiting
    - Research Site
  - Norfolk, Virginia, United States, 23504
    - Not yet recruiting
    - Research Site
  - Richmond, Virginia, United States, 23249
    - Withdrawn
    - Research Site
  - Salem, Virginia, United States, 24153
    - Recruiting
    - Research Site
- Washington
  - Puyallup, Washington, United States, 98372
    - Not yet recruiting
    - Research Site
  - Redmond, Washington, United States, 98052
    - Recruiting
    - Research Site
  - Renton, Washington, United States, 98057
    - Recruiting
    - Research Site
- West Virginia
  - Kingwood, West Virginia, United States, 26537
    - Recruiting
    - Research Site
  - Morgantown, West Virginia, United States, 26505
    - Recruiting
    - Research Site
- Wisconsin
  - Green Bay, Wisconsin, United States, 54303
    - Withdrawn
    - Research Site
  - Milwaukee, Wisconsin, United States, 53226
    - Withdrawn
    - Research Site
Vietnam
- - Can Tho, Vietnam, 900000
    - Not yet recruiting
    - Research Site
  - Haiphong, Vietnam, 180000
    - Recruiting
    - Research Site
  - Hanoi, Vietnam, 10000
    - Recruiting
    - Research Site
  - Ho Chi Minh City, Vietnam, 70000
    - Recruiting
    - Research Site
  - Ho Chi Minh City, Vietnam, 700000
    - Recruiting
    - Research Site
  - Ho Chi Minh City, Vietnam, 700000
    - Withdrawn
    - Research Site
  - Huế, Vietnam, 530000
    - Recruiting
    - Research Site
  - Hà Nội, Vietnam, 100000
    - Recruiting
    - Research Site
  - Rach Gia, Vietnam, 920000
    - Not yet recruiting
    - Research Site
  - Vĩnh Yên, Vietnam, 280000
    - Recruiting
    - Research Site

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

Adult
Older Adult

Accepts Healthy Volunteers

Description

Inclusion Criteria:

Participants of any sex and gender must be ≥ 40 years old at the time of signing the informed consent.
Diagnosed with T2DM and requiring treatment
Established CV disease (ischaemic heart disease, cerebrovascular disease, peripheral arterial disease)
History of HTN and an SBP ≥ 130 mmHg at screening and ≥ 120 mmHg at the Randomisation Visit.
At least one additional risk factor for HF:
- Age ≥ 70 years
- UACR > 20 mg/g
- eGFR < 60 mL/min/1.73 m2
- History of polyvascular disease (at least two of: ischaemic heart disease, cerebrovascular disease, and peripheral arterial disease)
- History of atrial fibrillation or atrial flutter
- NT-proBNP > 125 ng/L

Exclusion Criteria:

Previously confirmed diagnosis and treatment of heart failure
An eGFR < 30 mL/min/1.73 m2 at screening
Known hyperkalaemia, defined as potassium ≥ 5.5 mmol/L within 3 months prior to screening
Type 1 diabetes mellitus or uncontrolled T2DM with HbA1c > 10.5% (> 91 mmol/mol) at screening
Serum sodium < 135 mmol/L at screening, determined as per central laboratory assessment
Stroke, transient ischaemic cerebral attack, valve implantation or valve replacement, carotid surgery, carotid angioplasty, or cardiac surgery, within 3 months prior to randomisation
Myocardial infarction within 3 months prior to randomisation, or within 1 month prior to randomisation when there is no further planned revascularisation
Percutaneous coronary intervention within 1 month prior to randomisation
Known severe hepatic impairment, defined as Child-Pugh Class C, based on records that confirm documented medical history
Documented history of adrenal insufficiency
Any dialysis (including for acute kidney injury) within 3 months prior to screening
Any acute kidney injury within 3 months prior to screening
Prohibited concomitant medications

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Quadruple

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Baxdrostat/Dapagliflozin Participants randomised to the baxdrostat/dapagliflozin arm will initially receive a dose of baxdrostat lower dose and dapagliflozin. For participants that meet the up-titration criteria, baxdrostat may be up-titrated to higher dose.	Drug: Baxdrostat and dapagliflozin baxdrostat tablet and dapagliflozin tablet Other Names: Baxdrostat CIN-107
Experimental: Placebo/Dapagliflozin Patients will receive a dose of dapagliflozin in combination with matching placebo	Other: Placebo and dapagliflozin placebo tablet and dapagliflozin tablet

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
To determine if baxdrostat/dapagliflozin is superior to placebo/dapagliflozin in reducing the risk of an HF event or CV death Time Frame: Event driven; Up to 38 months	Time to first occurrence of any of the components of the composite of: Hospitalisation for HF HF without hospitalisation CV death	Event driven; Up to 38 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
To determine whether baxdrostat/dapagliflozin is superior to placebo/dapagliflozin in reducing the risk of hospitalisation for HF or CV death Time Frame: Event driven; Up to 38 months	Time to first occurrence of any of the components of the composite of: Hospitalisation for HF CV death	Event driven; Up to 38 months
To determine whether baxdrostat/dapagliflozin is superior to placebo/dapagliflozin in reducing the risk of HF events Time Frame: Event driven; Up to 38 months	Time to first occurrence of any of the components of the composite of: Hospitalisation for HF HF without hospitalisation	Event driven; Up to 38 months
To determine whether baxdrostat/dapagliflozin is superior to placebo/dapagliflozin in reducing the risk of CV death Time Frame: Event driven; Up to 38 months	Time to CV death	Event driven; Up to 38 months
To determine whether baxdrostat/dapagliflozin is superior to placebo/dapagliflozin in reducing the risk of all-cause mortality Time Frame: Event driven; Up to 38 months	Time to all-cause death	Event driven; Up to 38 months
To determine whether baxdrostat/dapagliflozin is superior to placebo/dapagliflozin in reducing the risk of 4-point MACE (CV death, MI, stroke, and hospitalisation for HF) Time Frame: Event driven; Up to 38 months	Time to first occurrence of any of the components of the composite of: CV death MI Stroke Hospitalisation for HF	Event driven; Up to 38 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

AstraZeneca

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Dwyer JP, Maklad N, Vedin O, Monyak J, Myte R, Chertow GM, Heerspink HJL, Little DJ. Efficacy and Safety of Baxdrostat in Participants with CKD and Uncontrolled Hypertension: A Randomized, Double-Blind, Placebo-Controlled Trial. J Am Soc Nephrol. 2026 Feb 1;37(2):299-311. doi: 10.1681/ASN.0000000849. Epub 2025 Sep 6.

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 14, 2025

Primary Completion (Estimated)

December 17, 2029

Study Completion (Estimated)

December 17, 2029

Study Registration Dates

First Submitted

November 5, 2024

First Submitted That Met QC Criteria

November 5, 2024

First Posted (Actual)

November 6, 2024

Study Record Updates

Last Update Posted (Actual)

May 18, 2026

Last Update Submitted That Met QC Criteria

May 15, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Heart failure: Baxdrostat; Dapagliflozin; cardiovascular

Additional Relevant MeSH Terms

Other Study ID Numbers

D6973C00001
2024-514506-32-00 (Registry Identifier: EU CT number)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal Vivli.org. All requests will be evaluated as per the AZ disclosure commitment: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure. "Yes", indicates that AZ are accepting requests for IPD, but this does not mean all requests will be approved.

IPD Sharing Time Frame

AstraZeneca will meet or exceed data availability as per the commitments made to the EFPIA/PhRMA Data-Sharing Principles. For details of our timelines, please refer to our disclosure commitment at: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure

IPD Sharing Access Criteria

When a request has been approved AstraZeneca will provide access to the anonymized individual patient-level data via secure research environment Vivli.org. A Signed Data Usage Agreement (non-negotiable contract for data accessors) must be in place before accessing requested information

IPD Sharing Supporting Information Type

STUDY_PROTOCOL
SAP

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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A Phase III, Randomised, Placebo-controlled, Event-driven Study to Evaluate the Effect of Baxdrostat in Combination With Dapagliflozin Compared With Dapagliflozin Alone on the Risk of Incident Heart Failure and Cardiovascular Death

Study Overview

Status

Conditions

Intervention / Treatment

Study Type

Enrollment (Estimated)

Phase

Contacts and Locations

Study Contact

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Secondary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Collaborators and Investigators

Sponsor

Publications and helpful links

General Publications

Study record dates

Study Major Dates

Study Start (Actual)

Primary Completion (Estimated)

Study Completion (Estimated)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Actual)

Study Record Updates

Last Update Posted (Actual)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

IPD Plan Description

IPD Sharing Time Frame

IPD Sharing Access Criteria

IPD Sharing Supporting Information Type

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product

Clinical Trials on Heart Failure

Clinical Trials on Baxdrostat and dapagliflozin

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