Fluid Responsiveness Tests in Critically Ill Patients During Admission to the Intensive Care Unit

Possibility of Applying Fluid Responsiveness Tests in Critically Ill Patients During Admission to the Intensive Care Unit - a Prospective Observational Study.

The goal of this observational study is to investigate the prevalence of conditions allowing the performance fluid responsiveness tests in critically ill patients during admission to the intensive care unit.

Study Overview

• Status: Completed
• Conditions: Heart Failure; Hypovolemia; Shock Circulatory

Detailed Description

Patients admitted to the intensive care unit are very often hemodynamically unstable. In these cases fluid responsiveness tests should be performed to assess whether the patient would benefit from the fluid administration.

However, fluid responsiveness tests have many limitations including lack of spontaneous breathing, necessity of invasive mechanical ventilation with tidal volume of > 8 mL/kg ideal body weight, regular hearth rhythm, and lack of abdominal hypertension.

In the study, the investigators evaluated the prevalence of conditions enabling the performance fluid responsiveness tests in patients admitted to the intensive care unit. An assessment was performed within the six hours after admission to the intensive care unit. Evaluation was based on transthoracic echocardiography, clinical examination of the patients, and data derived from anamnesis.

The following fluid responsiveness tests were included into assessment: passive leg raising test, end-expiratory occlusion test, pulse pressure variation, stroke volume variation, velocity time integral variation in left ventricle output track, tidal volume challenge, inferior vena cava diameter variation, and superior vena cava diameter variation.

The aim of the study was to assess how many patients have the conditions allowing performance fluid responsiveness tests during admission to the intensive care unit.

• Study Type: Observational
• Enrollment (Actual): 389

Contacts and Locations

Study Locations

• Poland
  • Opole, Poland, 45-401
    • Department of Anesthesiology and Intensive Care, Uniwersytecki Szpital Kliniczny w Opolu

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Probability Sample

Study Population

Adult patients admitted to the intensive care unit

Description

Inclusion Criteria:

1. Adult patients admitted to the intensive care unit

Exclusion Criteria:

1. Age under 18
2. The researcher unavailable in the intensive care unit
3. Patient assessment cannot be completed within the first six hours after admission to the ICU

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
Patients treated in the intensive care unit; Patients treated in the intensive care unit during the first six hours after admission.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
To assess the prevalence of conditions allowing the performance fluid responsiveness tests during admission to the intensive care unit.	The primary aim of the study is to assess the prevalence of conditions allowing the performance fluid responsiveness tests during admission to the intensive care unit.	Six hours after admission to the intensive care unit

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
To assess which fluid responsiveness test based on heart-lung interactions can be applied most often during admission to the intensive care unit	The secondary aim of the study is to assess which fluid responsiveness test based on heart-lung interaction can be applied most often during admission to the intensive care unit	Six hours after admission to the intensive care unit
To assess the percentage of patients in shock whom fluid responsiveness tests can be performed during admission to the intensive care unit	Secondary aim include an assessment the percentage of patients in shock whom fluid responsiveness tests can be performed during admission to the intensive care unit.	Six hours from the admission to the intensive care unit.

Collaborators and Investigators

• Sponsor: Uniwersytecki Szpital Kliniczny w Opolu

Study record dates

Study Major Dates

• Study Start (Actual): April 3, 2023
• Primary Completion (Actual): May 27, 2024
• Study Completion (Actual): May 27, 2024

Study Registration Dates

• First Submitted: December 7, 2024
• First Submitted That Met QC Criteria: December 7, 2024
• First Posted (Actual): December 11, 2024

Study Record Updates

• Last Update Posted (Actual): March 25, 2025
• Last Update Submitted That Met QC Criteria: December 28, 2024
• Last Verified: November 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Shock; Hypovolemia
• Other Study ID Numbers: PossFluRespTests

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No