A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes (ENLIGHTEN-1)

June 3, 2026 updated by: Eli Lilly and Company

A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Obesity or Overweight, Without Type 2 Diabetes

The purpose of this study is to evaluate the efficacy and safety of eloralintide in adults with obesity or overweight who do not have type 2 diabetes. The study has two phases: a main phase and an extension phase.

Participation in the main phase of the study will last about 75 weeks. Participants with prediabetes will continue in the extension phase for another 2 years.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

1980

Phase

  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

  • Name: Trial question or participation questions: 1-877-CTLILLY (1-877-285-4559) or
  • Phone Number: 1-317-615-4559
  • Email: LillyTrials@Lilly.com

Study Locations

  • Argentina
      • Buenos Aires, Argentina, 1012
        • Not yet recruiting
        • CONEXA Investigacion Clinica S.A.
        • Contact:
          • Phone Number: 5491169680411
        • Principal Investigator:
          • María Scioscia
      • Buenos Aires, Argentina, C1426ABP
        • Not yet recruiting
        • Fundación Respirar
        • Principal Investigator:
          • Marina Uhrig
        • Contact:
          • Phone Number: 5411 7078 1548
      • Buenos Aires, Argentina, 1425
        • Not yet recruiting
        • Cardiología Palermo
        • Contact:
          • Phone Number: 5491140306347
        • Principal Investigator:
          • Paula Perez Terns
      • Buenos Aires, Argentina, 1061
        • Not yet recruiting
        • CIPREC
        • Contact:
          • Phone Number: 5491128690843
        • Principal Investigator:
          • Fernando Guerlloy
      • Buenos Aires, Argentina, C1120AAC
        • Not yet recruiting
        • Centro Médico Viamonte
        • Principal Investigator:
          • Diego Aizenberg
        • Contact:
          • Phone Number: 54 1149635650
      • Buenos Aires, Argentina, 1430
        • Not yet recruiting
        • Glenny Corp. S.A.
        • Contact:
          • Phone Number: 01145445522
        • Principal Investigator:
          • Martin Koretzky
      • Buenos Aires, Argentina, 1424
        • Not yet recruiting
        • Cicemo Srl
        • Contact:
          • Phone Number: 5491157417654
        • Principal Investigator:
          • Pablo Costanzo
      • Buenos Aires, Argentina, C1014ACP
        • Not yet recruiting
        • CARDIAMET Investigaciones Médicas
        • Principal Investigator:
          • Angela Romero Zarante
        • Contact:
          • Phone Number: 5491165496764
      • Córdoba, Argentina, 5000
        • Not yet recruiting
        • Instituto de Investigaciones Clinicas Cordoba
        • Contact:
          • Phone Number: 03515102154
        • Principal Investigator:
          • Mauro Pautasso
      • Godoy Cruz, Argentina, M5501ARP
        • Not yet recruiting
        • CIPADI - Centro Integral de Prevencion y Atencion en Diabetes
        • Principal Investigator:
          • Pedro Rosario Fabian Calella
        • Contact:
          • Phone Number: +5492616109879
      • Rosario, Argentina, 2000
        • Not yet recruiting
        • INECO Neurociencias Orono
        • Contact:
          • Phone Number: (0341) 425 8695
        • Principal Investigator:
          • María Cappiello
      • Rosario, Argentina, 2000
        • Not yet recruiting
        • Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica
        • Contact:
          • Phone Number: 543416928531
        • Principal Investigator:
          • Horacio Sessa
      • Rosario, Argentina, 2000
        • Not yet recruiting
        • Instituto Especialidades de la Salud Rosario
        • Contact:
          • Phone Number: 5490341155092114
        • Principal Investigator:
          • Ana Chiesa
      • Rosario, Argentina, S2000DTB
        • Not yet recruiting
        • Laboratorio de Hemostasia y Trombosis
        • Principal Investigator:
          • Vanina Gorosito
        • Contact:
          • Phone Number: 5493413807234
      • SAN M. de Tucuman, Argentina, T4000AXL
        • Not yet recruiting
        • Centro de Investigaciones Médicas Tucumán
        • Principal Investigator:
          • Leonardo Serra
        • Contact:
          • Phone Number: 0381-4200180
      • San Miguel de Tucumán, Argentina, 4000
        • Not yet recruiting
        • Centro Modelo de Cardiología
        • Contact:
          • Phone Number: 3814444500
        • Principal Investigator:
          • GUILLERMO MERCAU
      • Santa Rosa, Argentina, L6300
        • Not yet recruiting
        • Centro de Salud e Investigaciones Médicas
        • Contact:
          • Phone Number: 542954244444
        • Principal Investigator:
          • Marcos Mayer
  • Australia
      • Botany, Australia, 2019
        • Not yet recruiting
        • Emeritus Research
        • Principal Investigator:
          • Paul Bird
      • Brisbane, Australia, 4064
        • Not yet recruiting
        • Core Research Group
        • Contact:
          • Phone Number: 61738765688
        • Principal Investigator:
          • David Colquhoun
      • Camberwell, Australia, 3124
        • Not yet recruiting
        • Emeritus Research
        • Principal Investigator:
          • Sam Francis
      • Ipswich, Australia, 4305
        • Not yet recruiting
        • Life Clinical Research
        • Contact:
          • Phone Number: 0734490036
        • Principal Investigator:
          • Cameron Booth
      • Kanwal, Australia, 2259
        • Not yet recruiting
        • Paratus Clinical Research Central Coast
        • Principal Investigator:
          • Dominic Douglas
        • Contact:
          • Phone Number: 611300742326
      • Meadowbrook, Australia, 4131
        • Not yet recruiting
        • University of the Sunshine Coast (UniSC) Clinical Trials - Meadowbrook
        • Principal Investigator:
          • Ivan Lim
      • Melbourne, Australia, 3021
        • Not yet recruiting
        • Momentum Sunshine
        • Contact:
          • Phone Number: 0395096166
        • Principal Investigator:
          • King Cheung
      • Melbourne, Australia, 3070
        • Not yet recruiting
        • Paratus Clinical Research - Melbourne
        • Principal Investigator:
          • Kianoosh Noori Samie
      • Merewether, Australia, 2291
        • Not yet recruiting
        • Aim Research
        • Principal Investigator:
          • Claire Morbey
        • Contact:
          • Phone Number: +61 2 4963 2323
      • Norwood, Australia, 5067
        • Not yet recruiting
        • Fusion Clinical Research
        • Principal Investigator:
          • Thomas Polasek
      • Sippy Downs, Australia, 4556
        • Not yet recruiting
        • USC Clinical Trials Sunshine Coast
        • Principal Investigator:
          • Robert Scott
  • Belgium
      • Diepenbeek, Belgium, 3590
        • Recruiting
        • ANIMA Research
        • Principal Investigator:
          • Hilde Bollen
        • Contact:
          • Phone Number: +32 11 94 91 15
      • Hasselt, Belgium, 3500
        • Recruiting
        • Jessa Ziekenhuis
        • Contact:
          • Phone Number: 011337030
        • Principal Investigator:
          • Guido Claessen
      • Kluisbergen, Belgium, 9690
        • Recruiting
        • Kormont
        • Principal Investigator:
          • Klaas Vercruysse
        • Contact:
          • Phone Number: 32 496 376259
      • Machelen, Belgium, 9870
        • Recruiting
        • Gezondheidshuis De Gloed
        • Principal Investigator:
          • Klaas Vercruysse
        • Contact:
          • Phone Number: 32 496 376259
  • Brazil
      • Brasília, Brazil, 72145-450
        • Not yet recruiting
        • Chronos Pesquisa Clínica
        • Principal Investigator:
          • Maira Polcheira
      • Campinas, Brazil, 13060-080
        • Not yet recruiting
        • Instituto de Pesquisa Clinica de Campinas
        • Principal Investigator:
          • Sylka Rodovalho
        • Contact:
          • Phone Number: 55 19 3267 0023
      • Fortaleza, Brazil, 60430-350
        • Not yet recruiting
        • Private Practice - Dr.Miguel N. Hissa
        • Principal Investigator:
          • Miguel Hissa
        • Contact:
          • Phone Number: 55 85 3214.6530
      • Marília, Brazil, 17504-072
        • Not yet recruiting
        • Centro de Pesquisa Clínica de Marília - CPCLIM
        • Principal Investigator:
          • José Sgarbi
        • Contact:
          • Phone Number: 55 14 21051477
      • Porto Alegre, Brazil, 90430-001
        • Not yet recruiting
        • Nucleo de Pesquisa Clínica do Rio Grande do Sul
        • Contact:
          • Phone Number: 555137796400
        • Principal Investigator:
          • Luis Henrique Canani
      • Rio de Janeiro, Brazil, 20241-180
        • Not yet recruiting
        • IBPClin - Instituto Brasil de Pesquisa Clínica
        • Contact:
          • Phone Number: 552125277979
        • Principal Investigator:
          • Renata Alexandra Pinheiro
      • Rio de Janeiro, Brazil, 22270-060
        • Not yet recruiting
        • Ruschel Medicina e Pesquisa Clínica
        • Contact:
          • Phone Number: 552135979708
        • Principal Investigator:
          • Luiza Siffert
      • São Paulo, Brazil, 04266-010
        • Not yet recruiting
        • CEPIC - Centro Paulista de Investigação Clínica
        • Contact:
          • Phone Number: 551122713450
        • Principal Investigator:
          • Breno Balabem Alves
      • São Paulo, Brazil, 01228-200
        • Not yet recruiting
        • CPCLIN
        • Principal Investigator:
          • Denise Franco
        • Contact:
          • Phone Number: 551126303777
      • Vitória, Brazil, 29055450
        • Not yet recruiting
        • CEDOES
        • Principal Investigator:
          • Camila Salim
        • Contact:
          • Phone Number: 5527988032878
      • Votuporanga, Brazil, 15500-269
        • Not yet recruiting
        • INTEGRAL Pesquisa e Ensino
        • Principal Investigator:
          • GRACIELLY PANTANO
        • Contact:
          • Phone Number: 55017997472217
  • Canada
      • Brampton, Canada, L6T 0G1
        • Recruiting
        • Aggarwal and Associates Limited
        • Contact:
          • Phone Number: 9054589033
        • Principal Investigator:
          • Naresh Aggarwal
      • Courtice, Canada, L1E 2J5
        • Recruiting
        • Med Trust Research
        • Principal Investigator:
          • Anojan Kathirkamanayagan
        • Contact:
          • Phone Number: 905-728-7915 ext. 5
      • Guelph, Canada, N1H 1B1
        • Recruiting
        • Dawson Clinical Research Inc.
        • Principal Investigator:
          • Garry Wallace
        • Contact:
          • Phone Number: 519-222-8251
      • Hamilton, Canada, L8J 0B6
        • Recruiting
        • Winterberry Research Inc.
        • Principal Investigator:
          • Steven Zizzo
        • Contact:
          • Phone Number: 365-366-6267
      • Hamilton, Canada, L8L 5G8
        • Recruiting
        • The Wharton Medical Clinic Clinical Trials Inc
        • Contact:
          • Phone Number: 9055238134 x 274
        • Principal Investigator:
          • Mateen Akhtar
      • Québec, Canada, G3K 2P8
        • Recruiting
        • Alpha Recherche Clinique
        • Principal Investigator:
          • Maggie Lévesque
        • Contact:
          • Phone Number: 418-847-1112
      • Québec, Canada, G2J 0C4
        • Recruiting
        • Alpha Recherche Clinique
        • Contact:
          • Phone Number: 418-704-1112
        • Principal Investigator:
          • Anne-Marie Beaulieu
      • Sarnia, Canada, N7T 4X3
        • Recruiting
        • Bluewater Clinical Research Group Inc.
        • Principal Investigator:
          • John O'Mahony
        • Contact:
          • Phone Number: 1 (519) 344-6612
      • Trois-Rivières, Canada, G9A 4P3
        • Recruiting
        • Diex Recherche Inc. Division Trois-Rivieres
        • Principal Investigator:
          • Jean-francois Naud
  • China
      • Beijing, China, 101200
        • Not yet recruiting
        • Beijing Pinggu District Hospital
        • Contact:
          • Phone Number: 13911080328
        • Principal Investigator:
          • yufeng li
      • Beijing, China, 1001199
        • Not yet recruiting
        • Luhe Hospital
        • Principal Investigator:
          • Dong Zhao
      • Chengdu, China, 610041
        • Not yet recruiting
        • West China Hospital Sichuan University
        • Contact:
          • Phone Number: 18980601658
        • Principal Investigator:
          • zhenmei an
      • Chengdu, China, 610072
        • Not yet recruiting
        • Sichuan Provincial People's Hospital
        • Principal Investigator:
          • Limin Tian
      • Guangzhou, China, 510280
        • Not yet recruiting
        • Zhujiang Hospital
        • Principal Investigator:
          • Jia Sun
      • Hefei, China, 230011
        • Not yet recruiting
        • The Second People's Hospital of Hefei
        • Principal Investigator:
          • Jun Ye
        • Contact:
          • Phone Number: 86-13956099720
      • Jinan, China, 250013
        • Not yet recruiting
        • Jinan Central Hospital
        • Contact:
          • Phone Number: 15318816218
        • Principal Investigator:
          • Xiaolin Dong
      • Luoyang Shi, China, 471003
        • Not yet recruiting
        • The First Affiliated Hospital of Henan University of Science &Technology
        • Principal Investigator:
          • Hongwei Jiang
        • Contact:
          • Phone Number: 13653880139
      • Nanchang, China, 330006
        • Not yet recruiting
        • Jiangxi Provincial People's Hospital
        • Principal Investigator:
          • Zongyou Cheng
        • Contact:
          • Phone Number: 13767035719
      • Nanjing, China, 210009
        • Not yet recruiting
        • Zhongda Hospital Southeast University
        • Principal Investigator:
          • Ling Li
      • Nanjing, China, 210006
        • Not yet recruiting
        • Nanjing First Hospital
        • Principal Investigator:
          • Qian Li
      • Nanjing, China, 210011
        • Not yet recruiting
        • The Second Affiliated Hospital of Nanjing Medical University
        • Principal Investigator:
          • Yibing Lu
        • Contact:
          • Phone Number: 18951762960
      • Nanjing, China, 210008
        • Not yet recruiting
        • Jiangsu Province Official Hospital
        • Principal Investigator:
          • Wei Tang
      • Shanghai, China
        • Not yet recruiting
        • Shanghai sixth people's hospital
        • Principal Investigator:
          • Jian Zhou
  • Germany
      • Cologne, Germany, 51069
        • Recruiting
        • Zentrum fur klinische Forschung - Köln
        • Principal Investigator:
          • Bastian Kirsch
        • Contact:
          • Phone Number: 00492212972813
      • Dresden, Germany, 01307
        • Recruiting
        • Universitaetsklinikum Carl Gustav Carus Dresden
        • Principal Investigator:
          • Nikolaos Perakakis
        • Contact:
          • Phone Number: 49 351 458 13651
      • Duisburg, Germany, 47269
        • Recruiting
        • StudyPoint Duisburg
        • Contact:
          • Phone Number: +491725448897
        • Principal Investigator:
          • Matthias Kuenster
      • Essen, Germany, 45355
        • Recruiting
        • Medizentrum Essen Borbeck
        • Contact:
          • Phone Number: 492018664428
        • Principal Investigator:
          • Axel Schaefer
      • Essen, Germany, 45136
        • Recruiting
        • InnoDiab Forschung GmbH
        • Principal Investigator:
          • Thomas Schürholz
        • Contact:
          • Phone Number: 49 201 89942100
      • Hamburg, Germany, 22607
        • Recruiting
        • Diabeteszentrum Hamburg West
        • Contact:
          • Phone Number: +49 40 896295
        • Principal Investigator:
          • Jens Aberle
      • Hamburg, Germany, 21109
        • Recruiting
        • Diabetes Zentrum Wilhelmsburg
        • Contact:
          • Phone Number: 0049407541703
        • Principal Investigator:
          • Peter Witzel
      • Leipzig, Germany, 04107
        • Recruiting
        • AmBeNet GmbH
        • Contact:
          • Phone Number: 4934196276326
        • Principal Investigator:
          • Hans-Detlev Stahl
      • Lingen, Germany, 49808
        • Recruiting
        • Diabetologische Schwerpunktpraxis Dr. Staudenmeyer & Dr. Schiwietz
        • Principal Investigator:
          • Andreas Staudenmeyer
        • Contact:
          • Phone Number: 0049591-90111110
      • Mainz, Germany, 55128
        • Recruiting
        • BAG Drs. Med. Quist PartG
        • Principal Investigator:
          • Sven Quist
        • Contact:
          • Phone Number: 00496131 9722360
      • Mannheim, Germany, 68167
        • Recruiting
        • CRS Clinical Research Services Mannheim
        • Principal Investigator:
          • Thomas Forst
        • Contact:
          • Phone Number: 004962115045279
      • Oldenburg, Germany, 23758
        • Recruiting
        • RED-Institut GmbH
        • Principal Investigator:
          • Thomas Schaum
        • Contact:
          • Phone Number: 0049436150630128
      • Wangen, Germany, 88239
        • Recruiting
        • Praxis Sauter & Sauter & Vorbach
        • Principal Investigator:
          • Joachim Sauter
        • Contact:
          • Phone Number: 0049 7522 70796060
  • India
      • Guntur, India, 522001
        • Not yet recruiting
        • Endolife Speciality Hospitals
        • Principal Investigator:
          • Kongara Srikanth
        • Contact:
          • Phone Number: 9849945577
      • Guwahati, India, 781032
        • Not yet recruiting
        • Gauhati Medical College and Hospital
        • Contact:
          • Phone Number: 9954658926
        • Principal Investigator:
          • Anjan Talukdar
      • Hyderabad, India, 500034
        • Not yet recruiting
        • Care Hospitals Hyderabad- Banjara Hills
        • Principal Investigator:
          • Bipin Sethi
        • Contact:
          • Phone Number: 91 8008646165
      • Mandya, India, 571401
        • Not yet recruiting
        • Mandya Institute Of Medical Sciences
        • Principal Investigator:
          • GV Anikethana
      • Mumbai, India, 400008
        • Not yet recruiting
        • Topiwala National Medical College & B. Y. L. Nair Charitable Hospital
        • Contact:
          • Phone Number: 9819893087
        • Principal Investigator:
          • Jugal Gada
      • Mysore, India, 570001
        • Not yet recruiting
        • Mysore Medical College
        • Principal Investigator:
          • Sumaiya Anjum
        • Contact:
          • Phone Number: 7760218464
      • Nagpur, India, 441108
        • Not yet recruiting
        • All India Institute of Medical Sciences (AIIMS) - Nagpur
        • Contact:
          • Phone Number: 9930805548
        • Principal Investigator:
          • Udit Narang
      • Nashik, India, 422002
        • Not yet recruiting
        • Supe Heart & Diabetes Hospital and Research Centre
        • Principal Investigator:
          • Pravin Supe
      • Pune, India, 411057
        • Not yet recruiting
        • Lifepoint Multispeciality Hospital
        • Contact:
          • Phone Number: 09730475068
        • Principal Investigator:
          • Amol Dange
      • Trichy, India, 620001
        • Not yet recruiting
        • Prabhu Diabetes Multi-Speciality Centre
        • Principal Investigator:
          • Venkatesan Ravindranath
  • Japan
      • Adachi-ku, Japan, 120-0022
        • Recruiting
        • Adachi Kyosai Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Manabu Yamamoto
      • Chūōku, Japan, 103-0027
        • Recruiting
        • Tokyo-Eki Center-building Clinic
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Arihiro Kiyosue
      • Chūōku, Japan, 103-0027
        • Recruiting
        • Medical Corporation Chiseikai Tokyo Center Clinic
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Aki Tsuji
      • Chūōku, Japan, 103-0025
        • Recruiting
        • Nihonbashi Sakura Clinic
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Kumie Ito
      • Fukuoka, Japan, 812-0025
        • Recruiting
        • Boocs Clinic Fukuoka
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Minoru Fujino
      • Minato, Japan, 105-0004
        • Recruiting
        • Patient First Clinic Ginza-Shimbashi
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Kimihiro Hayashi
      • Mitaka, Japan, 181-0013
        • Recruiting
        • Kanno Naika
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Kazuo Kanno
      • Suita-shi, Japan, 565-0853
        • Recruiting
        • Medical Corporation Heishinkai OCROM Clinic
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Yuko Soma
      • Tokyo, Japan, 169-0072
        • Recruiting
        • Higashi Shinjuku Clinic
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Hiroaki Kondo
  • Poland
      • Bialystok, Poland, 15-404
        • Recruiting
        • Legeartis - Poradnie Specjalistyczne
        • Principal Investigator:
          • Anna Modzelewska
        • Contact:
          • Phone Number: 48 507 18 11 18
      • Bialystok, Poland, 15-351
        • Recruiting
        • Zdrowie Osteo-Medic
        • Principal Investigator:
          • Katarzyna Wasilewska
        • Contact:
          • Phone Number: 48504055959
      • Krakow, Poland, 31-261
        • Recruiting
        • Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-MET
        • Contact:
          • Phone Number: 48126237122
        • Principal Investigator:
          • Joanna Mirocka
      • Lodz, Poland, 90-338
        • Recruiting
        • Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna
        • Contact:
          • Phone Number: 607536360
        • Principal Investigator:
          • Malgorzata Jozefowska
      • Lublin, Poland, 20-718
        • Recruiting
        • Ekamed
        • Principal Investigator:
          • Ewa Skokowska
        • Contact:
          • Phone Number: 48603787884
      • Lublin, Poland, 20-333
        • Recruiting
        • Gabinety TERPA
        • Contact:
          • Phone Number: 48814427272
        • Principal Investigator:
          • Beata Matyjaszek-Matuszek
      • Poznan, Poland, 60-589
        • Recruiting
        • Centrum Zdrowia Metabolicznego Pawel Bogdanski
        • Contact:
          • Phone Number: 48662023004
        • Principal Investigator:
          • Pawel Bogdanski
      • Wroclaw, Poland, 53-034
        • Recruiting
        • Pracownia Badan Klinicznych SALUS
        • Contact:
          • Phone Number: 607424301
        • Principal Investigator:
          • Katarzyna Madziarska
      • Zabrze, Poland, 41-800
        • Not yet recruiting
        • Samodzielny Publiczny Szpital Kliniczny nr 1 SUM
        • Principal Investigator:
          • Janusz Gumprecht
        • Contact:
          • Phone Number: 48 32 271 25 11
  • Puerto Rico
      • Dorado, Puerto Rico, 00646
        • Recruiting
        • Puerto Rico Health and Wellness Institute
        • Contact:
          • Phone Number: 7877961049
        • Principal Investigator:
          • Elham Ghorbani
      • Vega Baja, Puerto Rico, 00693
        • Recruiting
        • Wellness clinical Research Vega Baja
        • Principal Investigator:
          • Gustavo Albizu Angulo
        • Contact:
          • Phone Number: 787-654-9444
  • South Korea
      • Namdong-gu, South Korea, 21565
        • Recruiting
        • Gachon University Gil Medical Center
        • Principal Investigator:
          • Kyoung-Kon Kim
        • Contact:
          • Phone Number: +82-32-458-2778
      • Seogu, South Korea, 35365
        • Not yet recruiting
        • Konyang University Hospital
        • Principal Investigator:
          • Jee Hyun Kang
      • Seongnam, South Korea, 13620
        • Not yet recruiting
        • Seoul National University Bundang Hospital
        • Principal Investigator:
          • Kiheon Lee
      • Seoul, South Korea, 03080
        • Recruiting
        • Seoul National University Hospital
        • Contact:
          • Phone Number: 82220723497
        • Principal Investigator:
          • Minseon Park
      • Yangsan, South Korea, 50612
        • Not yet recruiting
        • Pusan National University Yangsan Hospital
        • Principal Investigator:
          • Sang Yeoup Lee
        • Contact:
          • Phone Number: 82-55-360-2860
  • Taiwan
      • Chiayi City, Taiwan, 600
        • Not yet recruiting
        • Chiayi Christian Hospital
        • Principal Investigator:
          • Chu-Kuang Chou
        • Contact:
          • Phone Number: 886-5-2765041
      • Kaohsiung City, Taiwan, 807
        • Not yet recruiting
        • Kaohsiung Medical University Chung-Ho Memorial Hospital
        • Principal Investigator:
          • Tsung-Hsien Lin
        • Contact:
          • Phone Number: 886-7-3121101 ext 7741
      • Kaohsiung Niao Sung Dist, Taiwan, 83301
        • Not yet recruiting
        • Chang Gung Memorial Hospital at Kaohsiung
        • Principal Investigator:
          • Chih-Yuan Fang
        • Contact:
          • Phone Number: 886 975056106
      • Taipei, Taiwan, 11217
        • Not yet recruiting
        • Taipei Veterans General Hospital
        • Principal Investigator:
          • Kang-Ling Wang
      • Taipei, Taiwan, 10002
        • Not yet recruiting
        • National Taiwan University Hospital
        • Principal Investigator:
          • Chih-Yuan Wang
        • Contact:
          • Phone Number: 0223123456
  • United Kingdom
      • Blackpool, United Kingdom, FY3 7EN
        • Not yet recruiting
        • Layton Medical Centre
        • Contact:
          • Phone Number: 441253951943
        • Principal Investigator:
          • Rebecca Clark
      • Bradford-on-Avon, United Kingdom, BA15 1DQ
        • Not yet recruiting
        • Bradford on Avon Health Centre
        • Principal Investigator:
          • Nell Wyatt
        • Contact:
          • Phone Number: 01225866611
      • Lancashire, United Kingdom, OL6 6EW
        • Not yet recruiting
        • Ashton Medical Group - Chapel House
        • Principal Investigator:
          • Omair Razzaq
      • Lancaster, United Kingdom, LA1 4RP
        • Not yet recruiting
        • Royal Lancaster Infirmary
        • Principal Investigator:
          • Mohamed Elnaggar
      • Londonderry, United Kingdom, BT47 6SB
        • Not yet recruiting
        • Altnagelvin Area Hospital
        • Principal Investigator:
          • Alex Miras
      • Manchester, United Kingdom, M11 1AA
        • Not yet recruiting
        • Bodyline Clinic - Openshaw
        • Principal Investigator:
          • Sandra Connell
      • Peterborough, United Kingdom, PE8 6PL
        • Not yet recruiting
        • Wansford Research Limited
        • Principal Investigator:
          • Matthew Davies
      • Romsey, United Kingdom, SO51 7QN
        • Not yet recruiting
        • Abbeywell Surgery
        • Principal Investigator:
          • Nicola Lester
        • Contact:
          • Phone Number: 01794 512218
      • Torpoint, United Kingdom, PL11 2TB
        • Not yet recruiting
        • Rame Group Practice
        • Contact:
          • Phone Number: 01752 817900
        • Principal Investigator:
          • Georgina Hatton
  • United States
    • Alabama
      • Tuscaloosa, Alabama, United States, 35405
        • Recruiting
        • MFA Clinical Research
        • Contact:
          • Phone Number: 205-331-4963
        • Principal Investigator:
          • Mohammad Aryanpure
    • Arizona
      • Scottsdale, Arizona, United States, 85260
        • Recruiting
        • Headlands Research - Scottsdale
        • Contact:
          • Phone Number: 480-725-8708
        • Principal Investigator:
          • Benjamin Clark
    • California
      • Escondido, California, United States, 92025
        • Recruiting
        • Neighborhood Healthcare Institute of Health
        • Contact:
          • Phone Number: 760-737-6984
        • Principal Investigator:
          • James Schultz
      • Fountain Valley, California, United States, 92708
        • Recruiting
        • ARK Clinical Research - Fountain Valley
        • Principal Investigator:
          • Mark Leibowitz
        • Contact:
          • Phone Number: 714-988-2021
      • Palm Springs, California, United States, 92262
        • Recruiting
        • Desert Oasis Healthcare Medical Group
        • Contact:
          • Phone Number: 760-320-9505
        • Principal Investigator:
          • Michael Jardula
      • Rolling Hills Estates, California, United States, 90274
        • Recruiting
        • Peninsula Research Associates
        • Contact:
          • Phone Number: 310-265-1623
        • Principal Investigator:
          • David Guzman
      • Sacramento, California, United States, 95831
        • Recruiting
        • Care Access - Sacramento
        • Principal Investigator:
          • Francisco Garcia
        • Contact:
          • Phone Number: 925-734-2331
      • Santa Ana, California, United States, 92701
        • Recruiting
        • Southern California Clinical Research
        • Contact:
          • Phone Number: 714-474-2173
        • Principal Investigator:
          • Wayne Ho
      • Tustin, California, United States, 92780
        • Recruiting
        • University Clinical Investigators, Inc.
        • Contact:
          • Phone Number: 714-734-7944
        • Principal Investigator:
          • John Kim
    • Connecticut
      • Waterbury, Connecticut, United States, 06708
        • Recruiting
        • Chase Medical Research, LLC
        • Principal Investigator:
          • Jenna Langello
        • Contact:
          • Phone Number: 203-437-6856
    • Florida
      • Atlantis, Florida, United States, 33462
        • Recruiting
        • JEM Research Institute
        • Principal Investigator:
          • David Halpert
        • Contact:
          • Phone Number: 561-968-2933
      • Miami, Florida, United States, 33156
        • Recruiting
        • BioMed Research & Medical Center
        • Principal Investigator:
          • Liliam Hernandez
        • Contact:
          • Phone Number: 786-238-7110
      • Mt. Dora, Florida, United States, 32757
        • Recruiting
        • Adult Medicine of Lake County, Inc.
        • Principal Investigator:
          • Shirley Nagel
        • Contact:
          • Phone Number: 352-383-8222
      • Pembroke Pines, Florida, United States, 33027
        • Recruiting
        • American Research Centers of Florida
        • Principal Investigator:
          • Luis del Prado Rodriguez
        • Contact:
          • Phone Number: 954-237-3799
      • Pensacola, Florida, United States, 32503
        • Recruiting
        • AHF Pensacola
        • Principal Investigator:
          • Mitchell Whitehead
        • Contact:
          • Phone Number: 850-476-3131 x53026
      • St. Petersburg, Florida, United States, 33704
        • Recruiting
        • IMA Clinical Research St. Petersburg
        • Contact:
          • Phone Number: 727-521-9137
        • Principal Investigator:
          • Howard Chipman
    • Georgia
      • Dunwoody, Georgia, United States, 30338
        • Recruiting
        • Teak Research Consults - Dunwoody
        • Principal Investigator:
          • Shani Belgrave
      • Lawrenceville, Georgia, United States, 30043
        • Recruiting
        • Teak Research Consults
        • Principal Investigator:
          • Kamar Alabi
      • Stockbridge, Georgia, United States, 30281
        • Recruiting
        • Clinical Research Atlanta
        • Contact:
          • Phone Number: 770-507-6867
        • Principal Investigator:
          • Jason Agran
    • Hawaii
      • Honolulu, Hawaii, United States, 96814
        • Recruiting
        • East-West Medical Research Institute
        • Principal Investigator:
          • Cindy Pau
        • Contact:
          • Phone Number: 808-531-6886
    • Iowa
      • West Des Moines, Iowa, United States, 50266
        • Recruiting
        • Iowa Diabetes and Endocrinology Research Center
        • Contact:
          • Phone Number: 515-329-6800
        • Principal Investigator:
          • Robert Burr
    • Kansas
      • Topeka, Kansas, United States, 66606
        • Recruiting
        • Cotton O'Neil Clinical Research Center
        • Contact:
          • Phone Number: 785-354-9591
        • Principal Investigator:
          • Katherine Willingham
    • Louisiana
      • Lake Charles, Louisiana, United States, 70601
        • Recruiting
        • Care Access - Lake Charles (Bayou Pines)
        • Contact:
          • Phone Number: 337-602-6642
        • Principal Investigator:
          • William Nabours
    • Maryland
      • Baltimore, Maryland, United States, 21239
        • Recruiting
        • MedStar Good Samaritan Hospital
        • Contact:
          • Phone Number: 443-444-6275
        • Principal Investigator:
          • Adline Ghazi
      • Hyattsville, Maryland, United States, 20782
        • Recruiting
        • MedStar Health Research Institute (MedStar Physician Based Research Network)
        • Principal Investigator:
          • Jean Park
        • Contact:
          • Phone Number: 443-444-5663
    • Massachusetts
      • Quincy, Massachusetts, United States, 02169
        • Recruiting
        • Care Access - Quincy
        • Contact:
          • Phone Number: 877-791-0656
        • Principal Investigator:
          • Chih Chao Yang
    • Michigan
      • Troy, Michigan, United States, 48098
        • Recruiting
        • Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
        • Contact:
          • Phone Number: 248-312-0025
        • Principal Investigator:
          • Neil Fraser
    • Nevada
      • Las Vegas, Nevada, United States, 89119
        • Recruiting
        • AMR Clinical
        • Principal Investigator:
          • Michael Jacobs
        • Contact:
          • Phone Number: 702-597-9825
    • New Jersey
      • Warren Township, New Jersey, United States, 07059
        • Recruiting
        • IMA Clinical Research Warren
        • Principal Investigator:
          • Nancy Phillips
    • New Mexico
      • Albuquerque, New Mexico, United States, 87102
        • Recruiting
        • Albuquerque Clinical Trials, Inc.
        • Contact:
          • Phone Number: 505-224-7407
        • Principal Investigator:
          • Satkirin Khalsa
    • New York
      • Rochester, New York, United States, 14609
        • Recruiting
        • Rochester Clinical Research, LLC
        • Contact:
          • Phone Number: 585-288-0890
        • Principal Investigator:
          • Leigh Schirmer
    • North Carolina
      • Monroe, North Carolina, United States, 28112
        • Recruiting
        • Monroe Biomedical Research
        • Principal Investigator:
          • Awawu Igbinadolor
        • Contact:
          • Phone Number: 704-283-7359
    • Pennsylvania
      • Uniontown, Pennsylvania, United States, 15401
        • Recruiting
        • Preferred Primary Care Physicians
        • Contact:
          • Phone Number: 724-912-0033
        • Principal Investigator:
          • Paul Hartley
    • South Carolina
      • Greenville, South Carolina, United States, 29607
        • Recruiting
        • Tribe Clinical Research, LLC
        • Principal Investigator:
          • Ronald Mayfield
        • Contact:
          • Phone Number: 864-334-0141
      • Mt. Pleasant, South Carolina, United States, 29464
        • Recruiting
        • Accellacare - Mt Pleasant
        • Contact:
          • Phone Number: 843-849-1880
        • Principal Investigator:
          • Richard Mills
    • Tennessee
      • Nashville, Tennessee, United States, 37203
        • Recruiting
        • AMR Clinical
        • Principal Investigator:
          • Harvey Bowles
        • Contact:
          • Phone Number: 630-491-1900
    • Texas
      • Bellaire, Texas, United States, 77401
        • Recruiting
        • The University of Texas Health Science Center at Houston
        • Contact:
          • Phone Number: 713-486-1350
        • Principal Investigator:
          • Deborah Horn
      • Dallas, Texas, United States, 75230
        • Recruiting
        • Velocity Clinical Research, Dallas
        • Principal Investigator:
          • Dan Lender
      • Dallas, Texas, United States, 75390-9302
        • Recruiting
        • UT Southwestern Medical Center
        • Principal Investigator:
          • Amy Shah
      • San Antonio, Texas, United States, 78229
        • Recruiting
        • Ima Clinical Research San Antonio
        • Contact:
          • Phone Number: 210-692-7157
        • Principal Investigator:
          • Priscilla Thomas
    • Virginia
      • Norfolk, Virginia, United States, 23502
        • Recruiting
        • AMR Clinical
        • Principal Investigator:
          • Mary Bailey
        • Contact:
          • Phone Number: 757-627-7446

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Have Body Mass Index (BMI) at screening of the following:

    • 30 kilogram per square meter (kg/m2) OR

    • 27 kg/m2 with at least one of the following weight-related health conditions at screening:

      • high blood pressure
      • dyslipidemia
      • obstructive sleep apnea, or
      • heart disease
  • Have a stable body weight (<5% body weight change) for 90 days prior to screening.
  • Have a history of at least one self-reported unsuccessful dietary effort to reduce body weight

Exclusion Criteria:

  • Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed >1 year before screening)
  • Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
  • Have type 1 diabetes or type 2 diabetes

  • Have had within 90 days prior to screening:

    • heart attack
    • stroke
    • coronary artery revascularization
    • unstable angina, or
    • hospitalization due to congestive heart failure
  • Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
  • Have taken medications or alternative remedies intended for weight loss within 90 days of screening

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Placebo Comparator: Placebo
Participants will receive placebo SC
Drug: Placebo
Administered SC
Experimental: Eloralintide Dose 1
Participants will receive eloralintide subcutaneously (SC)
Drug: Eloralintide
Administered SC
Other Names:
  • LY3841136
Experimental: Eloralintide Dose 2
Participants will receive eloralintide SC
Drug: Eloralintide
Administered SC
Other Names:
  • LY3841136
Experimental: Eloralintide Dose 3
Participants will receive eloralintide SC
Drug: Eloralintide
Administered SC
Other Names:
  • LY3841136
Experimental: Eloralintide Dose 4
Participants will receive eloralintide SC
Drug: Eloralintide
Administered SC
Other Names:
  • LY3841136

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Percent Change from Baseline in Body Weight
Time Frame: Baseline, Week 64
Baseline, Week 64

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Percent Change from Baseline in Total Body Fat Mass
Time Frame: Baseline, Week 64
Baseline, Week 64
Change from Baseline in Waist Circumference
Time Frame: Baseline, Week 64
Baseline, Week 64
Change from Baseline in Hemoglobin A1c (HbA1c)
Time Frame: Baseline, Week 64
Baseline, Week 64
Change from Baseline in Body Mass Index (BMI)
Time Frame: Baseline, Week 64
Baseline, Week 64
Percent Change from Baseline in Fasting Insulin
Time Frame: Baseline, Week 64
Baseline, Week 64
Change in Medication Use
Time Frame: Baseline through Week 64
Baseline through Week 64
Change from Baseline in Estimated Glomerular Filtration Rate (eGFR)
Time Frame: Baseline, Week 64
Baseline, Week 64
Change from Baseline in Control of Eating Questionnaire (CoEQ) Score
Time Frame: Baseline, Week 64
Baseline, Week 64
Pharmacokinetics (PK): Maximum Concentration at Steady State (Cmax,ss)
Time Frame: Baseline through Week 64
Baseline through Week 64
PK: Area Under the Concentration Versus Time Curve for One Dosing Interval at Steady State (AUC(0-ᴛ)ss)
Time Frame: Baseline through Week 64
Baseline through Week 64
Percent Change from Baseline in Triglycerides
Time Frame: Baseline, Week 64
Baseline, Week 64
Change from Baseline in Systolic Blood Pressure (SBP)
Time Frame: Baseline, Week 64
Baseline, Week 64
Time to Onset of Type 2 Diabetes (T2D)
Time Frame: Baseline to Week 168 and Week 191
Time to Onset of Type 2 Diabetes (T2D) in Participants with Prediabetes at Randomization
Baseline to Week 168 and Week 191
Percent Change from Baseline in High-Sensitivity C-Reactive Protein (hsCRP)
Time Frame: Baseline, Week 64
Baseline, Week 64
Change from Baseline in Short Form-36 Version 2 (SF-36 v2) Score
Time Frame: Baseline, Week 64
Baseline, Week 64
Change from Baseline in EQ-5D-5L
Time Frame: Baseline, Week 64
Baseline, Week 64
Achievement of Improved Categorical Shift in Patient Global Improvement of Status (PGIS) Physical Function Weight
Time Frame: Baseline, Week 64
Baseline, Week 64
Percent Change from Baseline in Body Weight in Participants with Prediabetes at Randomization
Time Frame: Baseline, Week 168
Baseline, Week 168

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Eli Lilly and Company

Investigators

  • Study Director: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST), Eli Lilly and Company

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 6, 2026

Primary Completion (Estimated)

March 1, 2028

Study Completion (Estimated)

July 1, 2030

Study Registration Dates

First Submitted

January 5, 2026

First Submitted That Met QC Criteria

January 5, 2026

First Posted (Actual)

January 7, 2026

Study Record Updates

Last Update Posted (Actual)

June 4, 2026

Last Update Submitted That Met QC Criteria

June 3, 2026

Last Verified

June 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 27742
  • J3R-MC-YDAG (Other Identifier: Eli Lilly and Company)
  • 2025-523657-34-00 (Other Identifier: EU CTIS)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.

IPD Sharing Time Frame

Data are available 6 months after the primary publication or approval of the indication studied in the US and EU, whichever is later. Data will be indefinitely available for requesting.

IPD Sharing Access Criteria

A research proposal should be approved by an independent review panel and researchers should sign a data sharing agreement.

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL
  • SAP
  • CSR

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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